[ { "uniprot_canonical_ac": "Q9QZX9-1", "uniprot_id": [ { "id": "CEP19_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZX9", "type": "external" } ], "mass": 19149.0, "length": 163, "protein_name": "Centrosomal protein of 19 kDa", "gene_name": "Cep19", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cep19", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 19 kDa; Cep19", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:192229)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring at centrosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0034454 microtubule anchoring at centrosome;GO:0097712 vesicle targeting, trans-Golgi to periciliary membrane compartment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M951-1", "uniprot_id": [ { "id": "CA174_RAT", "url": "https://www.uniprot.org/uniprot/Q5M951", "type": "external" } ], "mass": 23667.0, "length": 222, "protein_name": "UPF0688 protein C1orf174 homolog", "gene_name": "C5h1orf174", "organism": "Rat", "refseq_name": "UPF0688 protein C1orf174 homolog", "refseq_ac": [ { "id": "NP_001009711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009711", "type": "external" } ], "gene_names_uniprotkb": "C5h1orf174; RGD1304567", "gene_names_refseq": "C5h1orf174; RGD1304567", "protein_names_uniprotkb": "UPF0688 protein C1orf174 homolog", "protein_names_refseq": "UPF0688 protein C1orf174 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362671)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M951-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHY7-1", "uniprot_id": [ { "id": "BIRC5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHY7", "type": "external" } ], "mass": 16692.0, "length": 142, "protein_name": "Baculoviral IAP repeat-containing protein 5", "gene_name": "Birc5", "organism": "Rat", "refseq_name": "baculoviral IAP repeat-containing protein 5", "refseq_ac": [ { "id": "NP_071610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071610", "type": "external" } ], "gene_names_uniprotkb": "Birc5", "gene_names_refseq": "AP14; Birc5", "protein_names_uniprotkb": "Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin", "protein_names_refseq": "apoptosis inhibitor survivin; baculoviral IAP repeat-containing protein 5", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); high grade glioma (Disease Ontology:DOID:3070); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:64041); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-68877); (R-RNO-8951664); (R-RNO-9648025)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "30251448;33568044;34783140;35202039", "class_list": "", "function": "Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose. Publication Status: Online-Only, [RefSeq, PubMed]; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (By similarity)., [UniProtKB, UniProtKB]; Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation., [RefSeq, PubMed]; Survivin (BIRC5) regulates bladder fibrosis in a rat model of partial bladder outlet obstruction. Erratum:[Chin Med J (Engl). 2026 Jan 5;139(1):154. doi: 10.1097/CM9.0000000000003937. PMID: 41276484] Publication Status: Online-Only, [RefSeq, PubMed]; Survivin overexpression in the ischemic boundary zone induced by using an AAV vector has the potential for amelioration of ischemic damage via an antiapoptotic mechanism, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007059 chromosome segregation;GO:0043066 negative regulation of apoptotic process;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JHY7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4C1-1", "uniprot_id": [ { "id": "AT2C2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4C1", "type": "external" } ], "mass": 103020.0, "length": 944, "protein_name": "Calcium-transporting ATPase type 2C member 2", "gene_name": "Atp2c2", "organism": "Rat", "refseq_name": "calcium-transporting ATPase type 2C member 2", "refseq_ac": [ { "id": "NP_604457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604457", "type": "external" } ], "gene_names_uniprotkb": "Atp2c2; Spca2", "gene_names_refseq": "Atp2c2; Spca2", "protein_names_uniprotkb": "Calcium-transporting ATPase type 2C member 2; 7.2.2.10; ATPase 2C2; Ca(2+)/Mn(2+)-ATPase 2C2; SPCA2; Secretory pathway Ca(2+)-transporting ATPase type 2", "protein_names_refseq": "ATPase, Ca++ transporting, type 2C, member 2; Ca(2+)/Mn(2+)-ATPase 2C2; calcium-transporting ATPase 2C2; calcium-transporting ATPase type 2C member 2; putative secretory pathway Ca-ATPase SPCA2; secretory pathway Ca(2+)-ATPase 2; secretory pathway Ca(2+)-transporting ATPase type 2", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429)", "pathway": " (rno:171496); (R-RNO-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0140613 P-type manganese transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0090280 positive regulation of calcium ion import;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R4C1-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW1-1", "uniprot_id": [ { "id": "CCGL_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHW1", "type": "external" } ], "mass": 22871.0, "length": 209, "protein_name": "Voltage-dependent calcium channel gamma-like subunit", "gene_name": "Tmem37", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem37; Pr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-like subunit; Neuronal voltage-gated calcium channel gamma-like subunit; Transmembrane protein 37", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:245953)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11738816", "class_list": "", "function": "Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005244 voltage-gated monoatomic ion channel activity", "go_cellular_component": "GO:0034702 monoatomic ion channel complex;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WL2-1", "uniprot_id": [ { "id": "BYST_RAT", "url": "https://www.uniprot.org/uniprot/Q80WL2", "type": "external" } ], "mass": 50012.0, "length": 436, "protein_name": "Bystin", "gene_name": "Bysl", "organism": "Rat", "refseq_name": "bystin", "refseq_ac": [ { "id": "NP_872615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872615", "type": "external" } ], "gene_names_uniprotkb": "Bysl", "gene_names_refseq": "Bysl", "protein_names_uniprotkb": "Bystin", "protein_names_refseq": "bystin", "tax_id": 10116, "disease": "", "pathway": " (rno:359727); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15305856;22673903", "class_list": "", "function": "Bystin expressed by reactive astrocytes may be involved in astrocyte differentiation during the inflammatory processes following brain injury., [RefSeq, PubMed]; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYI7", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0008283 cell population proliferation;GO:0071222 cellular response to lipopolysaccharide;GO:1904322 cellular response to forskolin;GO:0001829 trophectodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XII8-1", "uniprot_id": [ { "id": "LTAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XII8", "type": "external" } ], "mass": 26642.0, "length": 235, "protein_name": "Lipid transport auxiliary protein 1", "gene_name": "Ltap1", "organism": "Rat", "refseq_name": "lipid transport auxiliary protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001014196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014196", "type": "external" } ], "gene_names_uniprotkb": "Ltap1; Ns5atp4l1; Ns5atp4", "gene_names_refseq": "Ltap1; Ns5atp4", "protein_names_uniprotkb": "Lipid transport auxiliary protein 1; Spigot ortholog", "protein_names_refseq": "NS5A (hepatitis C virus) transactivated protein 4 like 1; NS5A transactivated protein 4 like 1; lipid transport auxiliary protein 1 isoform 2; spigot ortholog; uncharacterized protein C1orf43 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for the formation of endoplasmic reticulum-plasma membrane junctions and functions as an accessory protein for bridge-like lipid transfer protein BLTP1, participating in lipid delivery between endoplasmic reticulum and cell membranes. Regulates the phagocytosis of Gram-negative bacteria like L. pneumophila and E. coli, as well as Gram-positive bacteria such as S. aureus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XII8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62730-1", "uniprot_id": [ { "id": "DHB2_RAT", "url": "https://www.uniprot.org/uniprot/Q62730", "type": "external" } ], "mass": 41967.0, "length": 381, "protein_name": "Estradiol 17-beta-dehydrogenase 2", "gene_name": "Hsd17b2", "organism": "Rat", "refseq_name": "estradiol 17-beta-dehydrogenase 2", "refseq_ac": [ { "id": "NP_077367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077367", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b2; Edh17b2", "gene_names_refseq": "Hsd17b2", "protein_names_uniprotkb": "Estradiol 17-beta-dehydrogenase 2; 1.1.1.239; 1.1.1.62; 17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase type 2; Testosterone 17-beta-dehydrogenase", "protein_names_refseq": "17-beta-HSD 2; 17-beta-hydroxysteroid dehydrogenase 2; 17-beta-hydroxysteroid dehydrogenase type 2; estradiol 17-beta-dehydrogenase 2; testosterone 17-beta-dehydrogenase", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (rno:79243); (R-RNO-193144)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22837477;8612487", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione (PubMed:8612487). Also has 20-alpha-HSD activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Gestational protein restriction reduces expression of Hsd17b2 in rat placental labyrinth. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001890 placenta development;GO:0032526 response to retinoic acid;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62730-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7A7-1", "uniprot_id": [ { "id": "CNRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7A7", "type": "external" } ], "mass": 18658.0, "length": 164, "protein_name": "CB1 cannabinoid receptor-interacting protein 1", "gene_name": "Cnrip1", "organism": "Rat", "refseq_name": "CB1 cannabinoid receptor-interacting protein 1", "refseq_ac": [ { "id": "NP_001014254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014254", "type": "external" } ], "gene_names_uniprotkb": "Cnrip1", "gene_names_refseq": "Cnrip1; Crip1a; RGD1308373", "protein_names_uniprotkb": "CB1 cannabinoid receptor-interacting protein 1; CRIP-1", "protein_names_refseq": "CB1 cannabinoid receptor interacting; CB1 cannabinoid receptor-interacting protein 1; CRIP-1", "tax_id": 10116, "disease": "", "pathway": " (rno:364208)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "17895407;18308297;18782338;22079489;23286559;25657338;27895162", "class_list": "", "function": "CRIP1a appears to act as a broad negative regulator of CB1 receptor function, [RefSeq, PubMed]; CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R., [RefSeq, PubMed]; Cnrip gene product, CRIP1a, inhibits basal activity of the CB1 cannabinoid receptor (cnr1)., [RefSeq, PubMed]; Gene expression levels of both cannabinoid receptor interacting protein 1 and CB1 receptor were elevated following kainic acid induced seizures., [RefSeq, PubMed]; Increased expression of CRIP1a in corpus striatum occurs after knockdown of CB1 receptor or dopamine D2 receptor., [RefSeq, PubMed]; Replication of the suppressive effects by CB1 antagonism in the nucleus accumbens and ventral tegmental area suggests that endocannabinoids and their receptors mediate ethanol reinforcement through interaction with the mesolimbic dopamine pathway., [RefSeq, PubMed]; Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels., [UniProtKB]; We conclude WIN inhibits the neurotransmission in the NTS of young rats via a receptor distinct from CB1 or CB2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A2RQR5", "ec_number_list": [], "go_molecular_function": "GO:0031718 type 1 cannabinoid receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:2000272 negative regulation of signaling receptor activity;GO:0010469 regulation of signaling receptor activity;GO:0150036 regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5M7A7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M845-1", "uniprot_id": [ { "id": "CD033_RAT", "url": "https://www.uniprot.org/uniprot/Q5M845", "type": "external" } ], "mass": 23341.0, "length": 199, "protein_name": "UPF0462 protein C4orf33 homolog", "gene_name": "C2h4orf33", "organism": "Rat", "refseq_name": "UPF0462 protein C4orf33 homolog", "refseq_ac": [ { "id": "NP_001009707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009707", "type": "external" } ], "gene_names_uniprotkb": "C2h4orf33", "gene_names_refseq": "C2h4orf33; RGD1359508", "protein_names_uniprotkb": "UPF0462 protein C4orf33 homolog", "protein_names_refseq": "UPF0462 protein C4orf33 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361941)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M845-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M886-1", "uniprot_id": [ { "id": "ADPRM_RAT", "url": "https://www.uniprot.org/uniprot/Q5M886", "type": "external" } ], "mass": 38712.0, "length": 337, "protein_name": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "gene_name": "Adprm", "organism": "Rat", "refseq_name": "manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "refseq_ac": [ { "id": "NP_001009246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009246", "type": "external" } ], "gene_names_uniprotkb": "Adprm", "gene_names_refseq": "ADPRibase-Mn; Adprm; MDS006; RGD1309906", "protein_names_uniprotkb": "Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; 3.6.1.16; 3.6.1.53; ADPRibase-Mn; CDP-choline phosphohydrolase", "protein_names_refseq": "CDP-choline phosphohydrolase; liver manganese (II)-dependent ADP-ribose/CDP-alcohol pyrophosphatase; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:287406); (R-RNO-2393930)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18352857;19379742;22848751", "class_list": "", "function": "Hydrolyzes ADP-ribose, ADP, CDP-glycerol, CDP-choline, CDP-ethanolamine and cyclic ADP-ribose (cADPR), but not other non-reducing ADP-sugars or CDP-glucose (PubMed:18352857, PubMed:19379742). May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress., [UniProtKB, PubMed, PubMed]; The phosphoanhydride bond of cyclic ADP-ribose or cADPR is hydrolyzed by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase., [RefSeq, PubMed]; The structure and function of Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase in immune tissues are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9Y0H8", "ec_number_list": [ { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0047734 CDP-glycerol diphosphatase activity;GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity;GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5M886-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M889-1", "uniprot_id": [ { "id": "APOF_RAT", "url": "https://www.uniprot.org/uniprot/Q5M889", "type": "external" } ], "mass": 33842.0, "length": 308, "protein_name": "Apolipoprotein F", "gene_name": "Apof", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Apof; Ba1-666", "gene_names_refseq": "", "protein_names_uniprotkb": "Apolipoprotein F; Apo-F; Liver regeneration-related protein LRRG151", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP25", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M889-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M971-1", "uniprot_id": [ { "id": "AF1Q_RAT", "url": "https://www.uniprot.org/uniprot/Q5M971", "type": "external" } ], "mass": 10030.0, "length": 90, "protein_name": "Protein AF1q", "gene_name": "Mllt11", "organism": "Rat", "refseq_name": "protein AF1q", "refseq_ac": [ { "id": "NP_001013934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013934", "type": "external" } ], "gene_names_uniprotkb": "Mllt11; Af1q", "gene_names_refseq": "Mllt11; RGD1305525", "protein_names_uniprotkb": "Protein AF1q", "protein_names_refseq": "AF1Q protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; protein AF1q; translocated to, 11", "tax_id": 10116, "disease": "", "pathway": " (rno:295264)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52KR8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0097191 extrinsic apoptotic signaling pathway;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M971-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G5-1", "uniprot_id": [ { "id": "CC117_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G5", "type": "external" } ], "mass": 30360.0, "length": 277, "protein_name": "Coiled-coil domain-containing protein 117", "gene_name": "Ccdc117", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 117", "refseq_ac": [ { "id": "NP_001017502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017502", "type": "external" } ], "gene_names_uniprotkb": "Ccdc117", "gene_names_refseq": "Ccdc117", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 117", "protein_names_refseq": "coiled-coil domain-containing protein 117", "tax_id": 10116, "disease": "", "pathway": " (rno:498404)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Facilitates DNA repair, cell cycle progression, and cell proliferation through its interaction with CIAO2B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0072686 mitotic spindle", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9G5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G7-1", "uniprot_id": [ { "id": "UTP25_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G7", "type": "external" } ], "mass": 87825.0, "length": 763, "protein_name": "U3 small nucleolar RNA-associated protein 25 homolog", "gene_name": "Utp25", "organism": "Rat", "refseq_name": "U3 small nucleolar RNA-associated protein 25 homolog", "refseq_ac": [ { "id": "NP_001014008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014008", "type": "external" } ], "gene_names_uniprotkb": "Utp25; Def; Diexf", "gene_names_refseq": "Def; Diexf; Utp25", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 25 homolog; Digestive organ expansion factor homolog; UTP25 small subunit processor component", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 25 homolog; UTP25, small subunit processor component; novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7", "tax_id": 10116, "disease": "", "pathway": " (rno:305076); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver (By similarity). Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0040019 positive regulation of embryonic development;GO:0030163 protein catabolic process;GO:0031648 protein destabilization;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9G7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G8-1", "uniprot_id": [ { "id": "DCA11_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G8", "type": "external" } ], "mass": 61877.0, "length": 549, "protein_name": "DDB1- and CUL4-associated factor 11", "gene_name": "Dcaf11", "organism": "Rat", "refseq_name": "DDB1- and CUL4-associated factor 11", "refseq_ac": [ { "id": "NP_001009686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009686", "type": "external" } ], "gene_names_uniprotkb": "Dcaf11; Wdr23", "gene_names_refseq": "Dcaf11; Wdr23", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 11; WD repeat-containing protein 23", "protein_names_refseq": "DDB1- and CUL4-associated factor 11; WD repeat domain 23; WD repeat-containing protein 23", "tax_id": 10116, "disease": "", "pathway": " (rno:305895); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0003016 respiratory system process;GO:0006979 response to oxidative stress;GO:0007613 memory;GO:0050890 cognition;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M9G8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NSW5-1", "uniprot_id": [ { "id": "DBX1_RAT", "url": "https://www.uniprot.org/uniprot/Q5NSW5", "type": "external" } ], "mass": 36403.0, "length": 335, "protein_name": "Homeobox protein DBX1", "gene_name": "Dbx1", "organism": "Rat", "refseq_name": "homeobox protein DBX1", "refseq_ac": [ { "id": "NP_001009644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009644", "type": "external" } ], "gene_names_uniprotkb": "Dbx1", "gene_names_refseq": "Dbx1", "protein_names_uniprotkb": "Homeobox protein DBX1; Developing brain homeobox protein 1", "protein_names_refseq": "developing brain homeobox protein 1; homeobox protein DBX1", "tax_id": 10116, "disease": "", "pathway": " (rno:292934)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11880342", "class_list": "", "function": "Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0021521 ventral spinal cord interneuron specification;GO:0021515 cell differentiation in spinal cord", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5NSW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPK1-1", "uniprot_id": [ { "id": "BRI3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPK1", "type": "external" } ], "mass": 13613.0, "length": 125, "protein_name": "Membrane protein BRI3", "gene_name": "Bri3", "organism": "Rat", "refseq_name": "membrane protein BRI3 isoform 1", "refseq_ac": [ { "id": "NP_001009604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009604", "type": "external" } ], "gene_names_uniprotkb": "Bri3", "gene_names_refseq": "Bri3", "protein_names_uniprotkb": "Membrane protein BRI3; Brain protein I3", "protein_names_refseq": "membrane protein BRI3 isoform 1; membrane protein BRI3", "tax_id": 10116, "disease": "", "pathway": " (rno:304284); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26617783", "class_list": "", "function": "MiR-323 might regulate ischemia/reperfusion-induced rat neuronal cell death via targeting BRI3. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQJ9-1", "uniprot_id": [ { "id": "CC175_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQJ9", "type": "external" } ], "mass": 96777.0, "length": 817, "protein_name": "Coiled-coil domain-containing protein 175", "gene_name": "Ccdc175", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 175", "refseq_ac": [ { "id": "NP_001157872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157872", "type": "external" } ], "gene_names_uniprotkb": "Ccdc175", "gene_names_refseq": "Ccdc175", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 175", "protein_names_refseq": "coiled-coil domain-containing protein 175; uncharacterized protein C14orf38 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQL4-1", "uniprot_id": [ { "id": "CLP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQL4", "type": "external" } ], "mass": 47738.0, "length": 425, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "Clp1", "organism": "Rat", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": [ { "id": "NP_001009599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009599", "type": "external" } ], "gene_names_uniprotkb": "Clp1", "gene_names_refseq": "Clp1; Heab; RGD1307679", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "ATP/GTP-binding protein; CLP1, cleavage and polyadenylation factor I subunit, homolog; cleavage and polyadenylation factor I subunit 1; polyadenylation factor Clp1; polynucleotide kinase Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; pre-mRNA cleavage complex II protein Clp1", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 10 (Disease Ontology:DOID:0060279)", "pathway": " (rno:311166); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.32", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQL4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQP9-1", "uniprot_id": [ { "id": "ARMC5_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQP9", "type": "external" } ], "mass": 96585.0, "length": 926, "protein_name": "Armadillo repeat-containing protein 5", "gene_name": "Armc5", "organism": "Rat", "refseq_name": "armadillo repeat-containing protein 5", "refseq_ac": [ { "id": "NP_001009455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009455", "type": "external" } ], "gene_names_uniprotkb": "Armc5", "gene_names_refseq": "Armc5", "protein_names_uniprotkb": "Armadillo repeat-containing protein 5", "protein_names_refseq": "armadillo repeat-containing protein 5", "tax_id": 10116, "disease": "ACTH-independent macronodular adrenal hyperplasia 2 (Disease Ontology:DOID:0111624)", "pathway": " (rno:361653)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation. The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II. The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2. Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0000785 chromatin", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0001701 in utero embryonic development;GO:0051607 defense response to virus;GO:0006633 fatty acid biosynthetic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQR3-1", "uniprot_id": [ { "id": "BTBD9_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQR3", "type": "external" } ], "mass": 69158.0, "length": 612, "protein_name": "BTB/POZ domain-containing protein 9", "gene_name": "Btbd9", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein 9 isoform 1", "refseq_ac": [ { "id": "NP_001013091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013091", "type": "external" } ], "gene_names_uniprotkb": "Btbd9", "gene_names_refseq": "Btbd9", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 9", "protein_names_refseq": "BTB (POZ) domain containing 9; BTB/POZ domain-containing protein 9 isoform 1; BTB/POZ domain-containing protein 9", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425)", "pathway": " (rno:294318)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22658601", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0042428 serotonin metabolic process;GO:0050804 modulation of chemical synaptic transmission;GO:0007616 long-term memory;GO:0060586 multicellular organismal-level iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQR3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QT56-1", "uniprot_id": [ { "id": "CLD19_RAT", "url": "https://www.uniprot.org/uniprot/Q5QT56", "type": "external" } ], "mass": 23315.0, "length": 224, "protein_name": "Claudin-19", "gene_name": "Cldn19", "organism": "Rat", "refseq_name": "claudin-19", "refseq_ac": [ { "id": "NP_001008514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008514", "type": "external" } ], "gene_names_uniprotkb": "Cldn19", "gene_names_refseq": "Cldn19; claudin-19", "protein_names_uniprotkb": "Claudin-19", "protein_names_refseq": "claudin-19", "tax_id": 10116, "disease": "renal hypomagnesemia 5 with ocular involvement (Disease Ontology:DOID:0060881)", "pathway": " (rno:298487)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31166708;31500238", "class_list": "", "function": "Claudin-19 mediates the effects of the NO/cGMP signaling cascade on the paracellular pathway in the thick ascending limb of the loop of Henle., [RefSeq, PubMed]; Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (By similarity). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that claudin-19 is part of the collecting duct tight junction (TJ) complex. Its presence in the TJ is under the control of ambient interstitial tonicity. Under iso-osmotic conditions, it is responsible for a high electrical transepithelial resistance and contributes to the tonicity-induced changes in paracellular ion selectivity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AY67", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0043297 apical junction assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5QT56-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJQ0-1", "uniprot_id": [ { "id": "CHST1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJQ0", "type": "external" } ], "mass": 46885.0, "length": 411, "protein_name": "Carbohydrate sulfotransferase 1", "gene_name": "Chst1", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 1", "refseq_ac": [ { "id": "NP_001011955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011955", "type": "external" } ], "gene_names_uniprotkb": "Chst1", "gene_names_refseq": "Chst1", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 1; 2.8.2.21; GST-1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; KS6ST; KSGal6ST; KSST; Keratan sulfate Gal-6 sulfotransferase", "protein_names_refseq": "GST-1; KS6ST; KSGal6ST; KSST; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; carbohydrate sulfotransferase 1; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; keratan sulfate Gal-6 sulfotransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:295934); (R-RNO-2022854)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (By similarity). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146 sulfotransferase activity;GO:0045130 keratan sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006954 inflammatory response;GO:0006790 sulfur compound metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJQ8-1", "uniprot_id": [ { "id": "CAHM2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJQ8", "type": "external" } ], "mass": 35931.0, "length": 323, "protein_name": "Calcium homeostasis modulator protein 2", "gene_name": "Calhm2", "organism": "Rat", "refseq_name": "calcium homeostasis modulator protein 2", "refseq_ac": [ { "id": "NP_001008307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008307", "type": "external" } ], "gene_names_uniprotkb": "Calhm2; Fam26b", "gene_names_refseq": "Calhm2; Fam26b; RGD1308276", "protein_names_uniprotkb": "Calcium homeostasis modulator protein 2; Protein FAM26B", "protein_names_refseq": "calcium homeostasis modulator 2; calcium homeostasis modulator protein 2; family with sequence similarity 26, member B", "tax_id": 10116, "disease": "dementia (Disease Ontology:DOID:1307); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:294019)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory response. May form intercellular gap junctions. The gating mechanism remains unknown., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0048167 regulation of synaptic plasticity;GO:0070509 calcium ion import;GO:1903978 regulation of microglial cell activation;GO:1904669 ATP export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJQ8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJT0-1", "uniprot_id": [ { "id": "ASHWN_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJT0", "type": "external" } ], "mass": 25787.0, "length": 232, "protein_name": "tRNA-splicing ligase complex subunit ASW", "gene_name": "C9h2orf49", "organism": "Rat", "refseq_name": "tRNA-splicing ligase complex subunit ASW", "refseq_ac": [ { "id": "NP_001008517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008517", "type": "external" } ], "gene_names_uniprotkb": "C9h2orf49", "gene_names_refseq": "C9h2orf49; RGD1310553", "protein_names_uniprotkb": "tRNA-splicing ligase complex subunit ASW", "protein_names_refseq": "ashwin; tRNA-splicing ligase complex subunit ASW", "tax_id": 10116, "disease": "", "pathway": " (rno:301374)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity and may function toward other RNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0072669 tRNA-splicing ligase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RK03-1", "uniprot_id": [ { "id": "C2AIL_RAT", "url": "https://www.uniprot.org/uniprot/Q5RK03", "type": "external" } ], "mass": 13197.0, "length": 116, "protein_name": "CDKN2AIP N-terminal-like protein", "gene_name": "Cdkn2aipnl", "organism": "Rat", "refseq_name": "CDKN2AIP N-terminal-like protein", "refseq_ac": [ { "id": "NP_001008279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008279", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2aipnl", "gene_names_refseq": "Cdkn2aipnl; RGD1308696; Xtbd1", "protein_names_uniprotkb": "CDKN2AIP N-terminal-like protein; CDKN2A-interacting protein N-terminal-like protein", "protein_names_refseq": "CDKN2A interacting protein N-terminal like; CDKN2A-interacting protein N-terminal-like protein; CDKN2AIP N-terminal-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:287278)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RK03-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKJ2-1", "uniprot_id": [ { "id": "CYBR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKJ2", "type": "external" } ], "mass": 31519.0, "length": 286, "protein_name": "Plasma membrane ascorbate-dependent reductase CYBRD1", "gene_name": "Cybrd1", "organism": "Rat", "refseq_name": "plasma membrane ascorbate-dependent reductase CYBRD1", "refseq_ac": [ { "id": "NP_001011954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011954", "type": "external" } ], "gene_names_uniprotkb": "Cybrd1; Dcytb", "gene_names_refseq": "Cybrd1; Dcytb", "protein_names_uniprotkb": "Plasma membrane ascorbate-dependent reductase CYBRD1; 7.2.1.3; Cytochrome b reductase 1; Duodenal cytochrome b", "protein_names_refseq": "duodenal cytochrome b; plasma membrane ascorbate-dependent reductase CYBRD1", "tax_id": 10116, "disease": "", "pathway": " (rno:295669); (R-RNO-917937)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16510471;17627967;22673903;23447582;23597830;25745840;29393594", "class_list": "", "function": "Data suggest that expression of Cybrd1 in intestinal mucosa can be regulated by dietary factors; here, expression of Cybrd1 in mucosa of duodenum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia., [RefSeq, PubMed]; Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that the presence of duodenal cytochrome b (Dcytb) in airway epithelial cells and its regulation by iron may contribute to pulmonary cytoprotection [Dcytb]., [RefSeq, PubMed]; There is an increase in hippocampal expression of duodenal Cybrd1 following kainic acid-induced excitotoxicity., [RefSeq, PubMed]; Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increases duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0016722 oxidoreductase activity, acting on metal ions;GO:0140575 transmembrane monodehydroascorbate reductase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0010039 response to iron ion;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5RKJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U206-1", "uniprot_id": [ { "id": "CALL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U206", "type": "external" } ], "mass": 16803.0, "length": 149, "protein_name": "Calmodulin-like protein 3", "gene_name": "Calml3", "organism": "Rat", "refseq_name": "calmodulin-like protein 3", "refseq_ac": [ { "id": "NP_001012054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012054", "type": "external" } ], "gene_names_uniprotkb": "Calml3", "gene_names_refseq": "Calml3", "protein_names_uniprotkb": "Calmodulin-like protein 3", "protein_names_refseq": "calmodulin-like protein 3", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:307100)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0043209 myelin sheath;GO:0150034 distal axon", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0005513 detection of calcium ion;GO:0051649 establishment of localization in cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U206-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2P0-1", "uniprot_id": [ { "id": "DI3L1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2P0", "type": "external" } ], "mass": 120759.0, "length": 1054, "protein_name": "DIS3-like exonuclease 1", "gene_name": "Dis3l", "organism": "Rat", "refseq_name": "DIS3-like exonuclease 1", "refseq_ac": [ { "id": "NP_001008381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008381", "type": "external" } ], "gene_names_uniprotkb": "Dis3l", "gene_names_refseq": "Dis3l; RGD1308959", "protein_names_uniprotkb": "DIS3-like exonuclease 1; 3.1.13.1", "protein_names_refseq": "DIS3 mitotic control homolog-like; DIS3-like exonuclease 1", "tax_id": 10116, "disease": "", "pathway": " (rno:363077)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006396 RNA processing;GO:0006402 mRNA catabolic process;GO:0016075 rRNA catabolic process;GO:0006401 RNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2P0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R2-1", "uniprot_id": [ { "id": "CA074_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R2", "type": "external" } ], "mass": 28591.0, "length": 263, "protein_name": "UPF0739 protein C1orf74 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "UPF0739 protein C1orf74 homolog", "refseq_ac": [ { "id": "NP_001096827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096827", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C13h1orf74; C1orf74", "protein_names_uniprotkb": "UPF0739 protein C1orf74 homolog", "protein_names_refseq": "UPF0739 protein C1orf74 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100125367)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2R2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2S6-1", "uniprot_id": [ { "id": "ASB2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2S6", "type": "external" } ], "mass": 70205.0, "length": 634, "protein_name": "Ankyrin repeat and SOCS box protein 2", "gene_name": "Asb2", "organism": "Rat", "refseq_name": "ankyrin repeat and SOCS box protein 2", "refseq_ac": [ { "id": "NP_001011984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011984", "type": "external" } ], "gene_names_uniprotkb": "Asb2", "gene_names_refseq": "Asb2", "protein_names_uniprotkb": "Ankyrin repeat and SOCS box protein 2; ASB-2", "protein_names_refseq": "ASB-2; ankyrin repeat and SOCS box protein 2-like; ankyrin repeat and SOCS box protein 2; ankyrin repeat and SOCS box-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:299266)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (By similarity). Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (By similarity). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0001725 stress fiber;GO:0030018 Z disc;GO:0000151 ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0007507 heart development;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2S6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2T8-1", "uniprot_id": [ { "id": "CIR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2T8", "type": "external" } ], "mass": 51416.0, "length": 451, "protein_name": "Corepressor of RBPJ and splicing regulator", "gene_name": "Cirsr", "organism": "Rat", "refseq_name": "corepressor of RBPJ and splicing regulator", "refseq_ac": [ { "id": "NP_001007800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007800", "type": "external" } ], "gene_names_uniprotkb": "Cirsr; Cir1; Cir", "gene_names_refseq": "1700023b02rik; Cir1; Cirsr; Cir; RGD1309199", "protein_names_uniprotkb": "Corepressor of RBPJ and splicing regulator; CBF1-interacting corepressor; Corepressor interacting with RBPJ 1", "protein_names_refseq": "CBF1 (RBPJ) interacting corepressor 1; CBF1-interacting corepressor; corepressor interacting with RBPJ, 1; corepressor interacting with RBPJ, CIR1; corepressor of RBPJ and splicing regulator", "tax_id": 10116, "disease": "", "pathway": " (rno:362149)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2X0-1", "uniprot_id": [ { "id": "CARF_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2X0", "type": "external" } ], "mass": 60744.0, "length": 570, "protein_name": "CDKN2A-interacting protein", "gene_name": "Cdkn2aip", "organism": "Rat", "refseq_name": "CDKN2A-interacting protein", "refseq_ac": [ { "id": "NP_001014022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014022", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2aip; Carf", "gene_names_refseq": "Cdkn2aip; RGD1305302", "protein_names_uniprotkb": "CDKN2A-interacting protein; Collaborator of ARF", "protein_names_refseq": "CDKN2A-interacting protein; collaborator of ARF", "tax_id": 10116, "disease": "", "pathway": " (rno:306455)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM89", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001652 granular component", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006974 DNA damage response;GO:0030308 negative regulation of cell growth;GO:0031647 regulation of protein stability;GO:0009967 positive regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2X0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Z5-1", "uniprot_id": [ { "id": "CMTR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Z5", "type": "external" } ], "mass": 95619.0, "length": 837, "protein_name": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "gene_name": "Cmtr1", "organism": "Rat", "refseq_name": "cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1", "refseq_ac": [ { "id": "NP_001014053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014053", "type": "external" } ], "gene_names_uniprotkb": "Cmtr1; Ftsjd2; RNF8", "gene_names_refseq": "Cmtr1; Ftsjd2; LRRG00129; MTr1; RGD1307801", "protein_names_uniprotkb": "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; 2.1.1.57; Cap methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; FtsJ methyltransferase domain-containing protein 2; MTr1", "protein_names_refseq": "FtsJ methyltransferase domain containing 2; S-adenosyl-L-methionine-dependent methyltransferase FTSJD2; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; cap1 2'O-ribose methyltransferase 1; ftsJ methyltransferase domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:309656)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2., [UniProtKB, HAMAP]; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.57", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0004483 methyltransferase cap1 activity;GO:0003676 nucleic acid binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030496 midbody;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0032259 methylation;GO:0006370 7-methylguanosine mRNA capping;GO:0016556 mRNA modification;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U310-1", "uniprot_id": [ { "id": "ARMX1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U310", "type": "external" } ], "mass": 51049.0, "length": 461, "protein_name": "Armadillo repeat-containing X-linked protein 1", "gene_name": "Armcx1", "organism": "Rat", "refseq_name": "armadillo repeat-containing X-linked protein 1", "refseq_ac": [ { "id": "NP_001019538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019538", "type": "external" } ], "gene_names_uniprotkb": "Armcx1", "gene_names_refseq": "Armcx1", "protein_names_uniprotkb": "Armadillo repeat-containing X-linked protein 1", "protein_names_refseq": "armadillo repeat-containing X-linked protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:501619)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U310-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4E8-1", "uniprot_id": [ { "id": "ANM7_RAT", "url": "https://www.uniprot.org/uniprot/Q5U4E8", "type": "external" } ], "mass": 78346.0, "length": 693, "protein_name": "Protein arginine N-methyltransferase 7", "gene_name": "Prmt7", "organism": "Rat", "refseq_name": "protein arginine N-methyltransferase 7", "refseq_ac": [ { "id": "NP_001014175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014175", "type": "external" } ], "gene_names_uniprotkb": "Prmt7", "gene_names_refseq": "Prmt7; RGD1304869", "protein_names_uniprotkb": "Protein arginine N-methyltransferase 7; 2.1.1.321; Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7", "protein_names_refseq": "[Myelin basic protein]-arginine N-methyltransferase PRMT7; histone-arginine N-methyltransferase PRMT7; protein arginine N-methyltransferase 7", "tax_id": 10116, "disease": "", "pathway": " (rno:361402); (R-RNO-3214858)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0042054 histone methyltransferase activity;GO:0042393 histone binding;GO:0044020 histone H4R3 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0018216 peptidyl-arginine methylation;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U4E8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XFV8-1", "uniprot_id": [ { "id": "COX14_RAT", "url": "https://www.uniprot.org/uniprot/Q5XFV8", "type": "external" } ], "mass": 6361.0, "length": 57, "protein_name": "Cytochrome c oxidase assembly protein COX14", "gene_name": "Cox14", "organism": "Rat", "refseq_name": "cytochrome c oxidase assembly protein COX14", "refseq_ac": [ { "id": "NP_001364010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001364010", "type": "external" } ], "gene_names_uniprotkb": "Cox14", "gene_names_refseq": "C12orf62; Cox14", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX14", "protein_names_refseq": "COX14 cytochrome c oxidase assembly; COX14, cytochrome c oxidase assembly factor; cytochrome c oxidase assembly protein 14; cytochrome c oxidase assembly protein COX14", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 10 (Disease Ontology:DOID:0070496)", "pathway": " (rno:681219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XFV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI03-1", "uniprot_id": [ { "id": "CEP95_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI03", "type": "external" } ], "mass": 94508.0, "length": 821, "protein_name": "Centrosomal protein of 95 kDa", "gene_name": "Cep95", "organism": "Rat", "refseq_name": "centrosomal protein of 95 kDa", "refseq_ac": [ { "id": "NP_001013884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013884", "type": "external" } ], "gene_names_uniprotkb": "Cep95; Ccdc45", "gene_names_refseq": "Ccdc45; Cep95; RGD1309655", "protein_names_uniprotkb": "Centrosomal protein of 95 kDa; Cep95; Coiled-coil domain-containing protein 45", "protein_names_refseq": "centrosomal protein 95kDa; centrosomal protein of 95 kDa; coiled-coil domain containing 45; coiled-coil domain-containing protein 45", "tax_id": 10116, "disease": "", "pathway": " (rno:287766)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI03-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIB3-1", "uniprot_id": [ { "id": "ARHL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIB3", "type": "external" } ], "mass": 39877.0, "length": 353, "protein_name": "Inactive ADP-ribosyltransferase ARH2", "gene_name": "Adprhl1", "organism": "Rat", "refseq_name": "inactive ADP-ribosyltransferase ARH2 isoform 1", "refseq_ac": [ { "id": "NP_001013072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013072", "type": "external" } ], "gene_names_uniprotkb": "Adprhl1; Arh2", "gene_names_refseq": "AABR07026536.1; Adprhl1", "protein_names_uniprotkb": "Inactive ADP-ribosyltransferase ARH2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1", "protein_names_refseq": "ADP-ribosylhydrolase 2; ADP-ribosylhydrolase-like protein 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1; inactive ADP-ribosyltransferase ARH2 isoform 1; inactive ADP-ribosyltransferase ARH2", "tax_id": 10116, "disease": "", "pathway": " (rno:290880)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for myofibril assembly and outgrowth of the cardiac chambers in the developing heart (By similarity). Appears to be catalytically inactive, showing no activity against O-acetyl-ADP-ribose (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003875 ADP-ribosylarginine hydrolase activity", "go_cellular_component": "GO:0030017 sarcomere", "go_biological_process": "GO:0055003 cardiac myofibril assembly;GO:0051725 protein de-ADP-ribosylation;GO:0003242 cardiac chamber ballooning", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF5-1", "uniprot_id": [ { "id": "DEGS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF5", "type": "external" } ], "mass": 38055.0, "length": 323, "protein_name": "Sphingolipid delta(4)-desaturase DES1", "gene_name": "Degs1", "organism": "Rat", "refseq_name": "sphingolipid delta(4)-desaturase DES1", "refseq_ac": [ { "id": "NP_445775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445775", "type": "external" } ], "gene_names_uniprotkb": "Degs1; Degs; Des1", "gene_names_refseq": "Degs1; Degs", "protein_names_uniprotkb": "Sphingolipid delta(4)-desaturase DES1; 1.14.19.17; 5.2.1.-; Degenerative spermatocyte homolog 1; Degenerative spermatocyte-like protein RDES; Dihydroceramide desaturase-1; Retinol isomerase", "protein_names_refseq": "degenerative spermatocyte homolog 1, lipid desaturase; degenerative spermatocyte-like protein RDES; dihydroceramide desaturase-1; retinol isomerase; sphingolipid delta(4)-desaturase DES1", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); hypomyelinating leukodystrophy 18 (Disease Ontology:DOID:0070399); neurodegenerative disease (Disease Ontology:DOID:1289); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:58970); (R-RNO-1660661); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21914808;22139871", "class_list": "", "function": "Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity). Catalyzes the equilibrium isomerization of retinols (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Overexpression of DEGS1 or DEGS2 attenuates the DHC accumulation and increased cell proliferation during hypoxia Erratum:[J Biol Chem. 2012 May 18;287(21):17425], [RefSeq, PubMed]; The myristic acid-associated increase in DES1 activity slightly enhanced the number of apoptotic cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q564G4;Q91XI6", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.14.18.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.5", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0042284 sphingolipid delta-4 desaturase activity;GO:0016859 cis-trans isomerase activity;GO:0050251 retinol isomerase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0043065 positive regulation of apoptotic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIF5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIJ5-1", "uniprot_id": [ { "id": "AB17A_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIJ5", "type": "external" } ], "mass": 33994.0, "length": 310, "protein_name": "Alpha/beta hydrolase domain-containing protein 17A", "gene_name": "Abhd17a", "organism": "Rat", "refseq_name": "alpha/beta hydrolase domain-containing protein 17A", "refseq_ac": [ { "id": "NP_001006984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006984", "type": "external" } ], "gene_names_uniprotkb": "Abhd17a", "gene_names_refseq": "Abhd17a; Fam108a1; Fam108a; RGD1359682; upf0227", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17A; 3.1.2.22; Abhydrolase domain-containing protein 17A", "protein_names_refseq": "abhydrolase domain-containing protein 17A; abhydrolase domain-containing protein FAM108A; alpha/beta hydrolase domain-containing protein 17A; family with sequence similarity 108, member A1; protein ABHD17A", "tax_id": 10116, "disease": "", "pathway": " (rno:299617); (R-RNO-9648002)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "27307232;28521134", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:27307232). Has depalmitoylating activity towards NRAS (By similarity). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:27307232). May have depalmitoylating activity towards MAP6 (PubMed:28521134)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:0072657 protein localization to membrane;GO:0002084 protein depalmitoylation;GO:1900226 negative regulation of NLRP3 inflammasome complex assembly;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIK1-1", "uniprot_id": [ { "id": "ACTT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIK1", "type": "external" } ], "mass": 42195.0, "length": 376, "protein_name": "Actin-related protein T1", "gene_name": "Actrt1", "organism": "Rat", "refseq_name": "actin-related protein T1", "refseq_ac": [ { "id": "NP_001013983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013983", "type": "external" } ], "gene_names_uniprotkb": "Actrt1", "gene_names_refseq": "Actrt1", "protein_names_uniprotkb": "Actin-related protein T1", "protein_names_refseq": "actin-related protein T1", "tax_id": 10116, "disease": "", "pathway": " (rno:302796)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIK1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIL6-1", "uniprot_id": [ { "id": "ABHGB_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIL6", "type": "external" } ], "mass": 53294.0, "length": 474, "protein_name": "ABHD16B", "gene_name": "Abhd16b", "organism": "Rat", "refseq_name": "ABHD16B", "refseq_ac": [ { "id": "NP_001014074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014074", "type": "external" } ], "gene_names_uniprotkb": "Abhd16b", "gene_names_refseq": "Abhd16b; RGD1309726", "protein_names_uniprotkb": "ABHD16B; 3.1.1.111; Abhydrolase domain-containing protein 16B; Alpha/beta hydrolase domain-containing protein 16B", "protein_names_refseq": "ABHD16B; abhydrolase domain-containing protein 16B; alpha/beta hydrolase domain-containing protein 16B; protein ABHD16B", "tax_id": 10116, "disease": "", "pathway": " (rno:311720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the sn-1 position of glycerophospholipids with high specificity towards phosphatidylserine (PS), PS-PLA1 enzyme. Also hydrolyzes the acyl chain of glycerolipids with a preference for the monoacylglycerol (MAG) 1-acylglycerol, MAG lipase. Plays a regulatory role in cellular lipid homeostasis by modulating genes involved in neutral lipid degradation and in phospholipid synthesis and composition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIL6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIM4-1", "uniprot_id": [ { "id": "ATP5S_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIM4", "type": "external" } ], "mass": 23324.0, "length": 200, "protein_name": "ATP synthase subunit s, mitochondrial", "gene_name": "Dmac2l", "organism": "Rat", "refseq_name": "ATP synthase subunit s, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001007750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007750", "type": "external" } ], "gene_names_uniprotkb": "Dmac2l; Atp5s", "gene_names_refseq": "Atp5s; Dmac2l", "protein_names_uniprotkb": "ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; Distal membrane arm assembly complex 2-like protein; Mitochondrial ATP synthase regulatory component factor B", "protein_names_refseq": "ATP synthase subunit s, mitochondrial precursor; ATP synthase subunit s, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B); ATP synthase-coupling factor B; Factor B; distal membrane arm assembly complex 2 like; distal membrane arm assembly complex 2-like protein; mitochondrial ATP synthase regulatory component factor B", "tax_id": 10116, "disease": "", "pathway": " (rno:362749); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIR8-1", "uniprot_id": [ { "id": "CLHC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIR8", "type": "external" } ], "mass": 67543.0, "length": 585, "protein_name": "Clathrin heavy chain linker domain-containing protein 1", "gene_name": "Clhc1", "organism": "Rat", "refseq_name": "clathrin heavy chain linker domain-containing protein 1", "refseq_ac": [ { "id": "NP_001013899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013899", "type": "external" } ], "gene_names_uniprotkb": "Clhc1; C2orf63", "gene_names_refseq": "Clhc1; RGD1307937", "protein_names_uniprotkb": "Clathrin heavy chain linker domain-containing protein 1", "protein_names_refseq": "clathrin heavy chain linker domain-containing protein 1; uncharacterized protein C2orf63 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:289865)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62622-1", "uniprot_id": [ { "id": "4EBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q62622", "type": "external" } ], "mass": 12404.0, "length": 117, "protein_name": "Eukaryotic translation initiation factor 4E-binding protein 1", "gene_name": "Eif4ebp1", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 4E-binding protein 1", "refseq_ac": [ { "id": "NP_446309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446309", "type": "external" } ], "gene_names_uniprotkb": "Eif4ebp1", "gene_names_refseq": "Eif4ebp1; PHAS-I", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; eIF4E-binding protein 1", "protein_names_refseq": "4E-BP1; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1", "tax_id": 10116, "disease": "tuberous sclerosis (Disease Ontology:DOID:13515); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:116636); (R-RNO-166208); (R-RNO-72662)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "18683930;22673903;24691733;26998719;27313212;28041982;29761560;32208000;34874016;7939721;8083223;8170978;9092573;9381973;9806882", "class_list": "", "function": "FGF signaling differentially impacts protein synthesis through either stimulation or repression, in a cell-type-dependent manner, with 4E-BP1 being a key player., [RefSeq, PubMed]; In an anterior cruciate ligament transection model of osteoarthritis, 4E-BP1 inactivation precedes cartilage degeneration and increased expression of pathogenic proteases in cartilage., [RefSeq, PubMed]; MTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats. Publication Status: Online-Only, [RefSeq, PubMed]; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721)., [UniProtKB, UniProtKB, PubMed]; Suggest that 4-nonylphenol stimulates Sertoli cell autophagy and inhibits mTOR-p70S6K/4EBP1 activity through AMPK activation., [RefSeq, PubMed]; These results indicate that a low-protein diet increases the amount of 4E-BP1, leading to TG accumulation in rat liver. We thus conclude that 4E-BP1 plays an important role in inducing hepatic steatosis under protein deprivation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity;GO:0051721 protein phosphatase 2A binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0002931 response to ischemia;GO:0045471 response to ethanol;GO:0045931 positive regulation of mitotic cell cycle;GO:0030324 lung development;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62622-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62682-1", "uniprot_id": [ { "id": "CNTN3_RAT", "url": "https://www.uniprot.org/uniprot/Q62682", "type": "external" } ], "mass": 112789.0, "length": 1028, "protein_name": "Contactin-3", "gene_name": "Cntn3", "organism": "Rat", "refseq_name": "contactin-3 precursor", "refseq_ac": [ { "id": "NP_062202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062202", "type": "external" } ], "gene_names_uniprotkb": "Cntn3", "gene_names_refseq": "BIG-1; Cntn3; Pang", "protein_names_uniprotkb": "Contactin-3; BIG-1; Brain-derived immunoglobulin superfamily protein 1", "protein_names_refseq": "Plasmacytoma-associated neuronal glycoprotein (neural cell adhesion molecule BIG-1); brain-derived immunoglobulin superfamily protein 1; contactin 3 (plasmacytoma associated); contactin-3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:54279); (R-RNO-163125)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10.1039/D0MO00044B;34106099;8060619", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0098552 side of membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62682-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62713-1", "uniprot_id": [ { "id": "DEF3A_RAT", "url": "https://www.uniprot.org/uniprot/Q62713", "type": "external" } ], "mass": 9341.0, "length": 87, "protein_name": "Neutrophil antibiotic peptide NP-3A", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Neutrophil antibiotic peptide NP-3A; Neutrophil defensin 3; RatNP-3a", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2543629;29393594;7594610", "class_list": "", "function": "Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62713-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62715-1", "uniprot_id": [ { "id": "DEF2_RAT", "url": "https://www.uniprot.org/uniprot/Q62715", "type": "external" } ], "mass": 10302.0, "length": 94, "protein_name": "Neutrophil antibiotic peptide NP-2", "gene_name": "Defa", "organism": "Rat", "refseq_name": "neutrophil antibiotic peptide NP-2 precursor", "refseq_ac": [ { "id": "NP_775451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775451", "type": "external" } ], "gene_names_uniprotkb": "Defa", "gene_names_refseq": "Defa5; Defa; ratNP-1; ratNP-2", "protein_names_uniprotkb": "Neutrophil antibiotic peptide NP-2; Neutrophil defensin 2; RatNP-2", "protein_names_refseq": "alpha-defensin 5, Paneth cell-specific; defensin NP-2; defensin, alpha 5, Paneth cell-specific; neutrophil antibiotic peptide NP-1; neutrophil antibiotic peptide NP-2 precursor; neutrophil antibiotic peptide NP-2; neutrophil defensin 1; neutrophil defensin 2", "tax_id": 10116, "disease": "", "pathway": " (rno:286995); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "2254017;30480410;7594610", "class_list": "", "function": "Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus., [UniProtKB]; The data obtained may indicate involvement of genes Tlr2, Muc2, Defa in development of inflammation in the duodenum due to dysbiotic changes under conditions of prolonged hypochlorhydria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62715-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62716-1", "uniprot_id": [ { "id": "DEF1_RAT", "url": "https://www.uniprot.org/uniprot/Q62716", "type": "external" } ], "mass": 10371.0, "length": 94, "protein_name": "Neutrophil antibiotic peptide NP-1", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Neutrophil antibiotic peptide NP-1; Neutrophil defensin 1; RatNP-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2543629;7594610", "class_list": "", "function": "Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62716-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62781-1", "uniprot_id": [ { "id": "ANRE_RAT", "url": "https://www.uniprot.org/uniprot/Q62781", "type": "external" } ], "mass": 13199.0, "length": 120, "protein_name": "Kidney androgen-regulated protein", "gene_name": "Kap", "organism": "Rat", "refseq_name": "kidney androgen-regulated protein precursor", "refseq_ac": [ { "id": "NP_434689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434689", "type": "external" } ], "gene_names_uniprotkb": "Kap", "gene_names_refseq": "Kap", "protein_names_uniprotkb": "Kidney androgen-regulated protein; ARP; KAP", "protein_names_refseq": "ARP; Kidney androgen-regulated protein; kidney androgen-regulated protein precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:24937)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q62781-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62847-1", "uniprot_id": [ { "id": "ADDG_RAT", "url": "https://www.uniprot.org/uniprot/Q62847", "type": "external" } ], "mass": 78818.0, "length": 705, "protein_name": "Gamma-adducin", "gene_name": "Add3", "organism": "Rat", "refseq_name": "gamma-adducin isoform 1", "refseq_ac": [ { "id": "NP_001157575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157575", "type": "external" } ], "gene_names_uniprotkb": "Add3", "gene_names_refseq": "Add3", "protein_names_uniprotkb": "Gamma-adducin; Adducin-like protein 70; Protein kinase C-binding protein 35H", "protein_names_refseq": "adducin 3 (gamma); adducin-like protein 70; gamma-adducin isoform 1; gamma-adducin; potein kinase C binding protein 35H; protein kinase C-binding protein 35H", "tax_id": 10116, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); hypertension (Disease Ontology:DOID:10763); biliary atresia (Disease Ontology:DOID:13608); cerebral palsy (Disease Ontology:DOID:1969); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:25230); (R-RNO-5223345); (R-RNO-9035034)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "22673903;27927653;29393594;32029431;32830539;33308016;33414130;7592723;9299427", "class_list": "", "function": "A Mutation in gamma-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. GeneRIF: A mutation in ADD3 that alters ACTIN binding causes renal vascular dysfunction and promotes the susceptibility to kidney disease., [RefSeq, PubMed]; Add3 may play a causal role in the impaired myogenic response and autoregulation in the renal and cerebral circulation in hypertensive rats. GeneRIF: Mutation of Add3 may play a causal role in the impaired myogenic response and blood flow autoregulation in the renal and cerebral circulation., [RefSeq, PubMed]; Knockout of gamma-Adducin Promotes N(G)-Nitro-L-Arginine-Methyl-Ester-Induced Hypertensive Renal Injury., [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin (By similarity). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure (PubMed:27927653, PubMed:32029431, PubMed:32830539). Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo (PubMed:27927653, PubMed:32029431). Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension (PubMed:32830539, PubMed:33414130). Involved in renal blood flow (RBF) autoregulation (PubMed:32029431, PubMed:32830539, PubMed:33414130). Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement (PubMed:33308016). Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (PubMed:33414130). Promotes the growth of neurites (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Role of gamma-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology. GeneRIF: Reduced ADD3 function in FHH rats alters baseline podocyte pathophysiology by rearrangement of the actin cytoskeleton at the onset of proteinuria in young animals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZCH7;G3V9D7", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding;GO:0003779 actin binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0051495 positive regulation of cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0045907 positive regulation of vasoconstriction;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62847-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63041-1", "uniprot_id": [ { "id": "A1M_RAT", "url": "https://www.uniprot.org/uniprot/Q63041", "type": "external" } ], "mass": 167125.0, "length": 1500, "protein_name": "Alpha-1-macroglobulin", "gene_name": "A1m; Pzp2", "organism": "Rat", "refseq_name": "alpha-1-macroglobulin precursor", "refseq_ac": [ { "id": "NP_665722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665722", "type": "external" } ], "gene_names_uniprotkb": "A1m; Pzp2; Pzp", "gene_names_refseq": "A1m; Pzp2; Pzp", "protein_names_uniprotkb": "Alpha-1-macroglobulin; Alpha-1-M; Alpha-1-macroglobulin 165 kDa subunit", "protein_names_refseq": "PZP, alpha-2-macroglobulin like; PZP2, alpha-2-macroglobulin like; alpha-1-M; alpha-1-macroglobulin 165 kDa subunit; alpha-1-macroglobulin precursor; pregnancy-zone protein", "tax_id": 10116, "disease": "", "pathway": " (rno:252922)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11106161;1371696;1725450;18301350;29393594;34502162", "class_list": "", "function": "Alpha1-M is proved to be a potential serum factor related to obesity proneness and obesity resistance., [RefSeq, PubMed]; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q63332", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63041-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63042-1", "uniprot_id": [ { "id": "ALR_RAT", "url": "https://www.uniprot.org/uniprot/Q63042", "type": "external" } ], "mass": 22837.0, "length": 198, "protein_name": "FAD-linked sulfhydryl oxidase ALR", "gene_name": "Gfer", "organism": "Rat", "refseq_name": "FAD-linked sulfhydryl oxidase ALR", "refseq_ac": [ { "id": "NP_037354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037354", "type": "external" } ], "gene_names_uniprotkb": "Gfer; Alr", "gene_names_refseq": "ALR; Gfer", "protein_names_uniprotkb": "FAD-linked sulfhydryl oxidase ALR; 1.8.3.2; Augmenter of liver regeneration", "protein_names_refseq": "FAD-linked sulfhydryl oxidase ALR-like; FAD-linked sulfhydryl oxidase ALR; growth factor, erv1 homolog; growth factor, erv1-like (augmenter of liver regeneration); translation initiation factor IF-2-like", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); autosomal recessive centronuclear myopathy (Disease Ontology:DOID:0111216); kidney failure (Disease Ontology:DOID:1074); cryptorchidism (Disease Ontology:DOID:11383); acute kidney failure (Disease Ontology:DOID:3021); ureteral obstruction (Disease Ontology:DOID:5199); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:27100)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12717032;12906155;22948913;24880092;29393594;33878312;8058770", "class_list": "", "function": "Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus., [RefSeq, PubMed]; FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. May have a function in liver regeneration and spermatogenesis., [UniProtKB, PubMed]; Our results demonstrate that Growth Factor Erv1-Like gene knock-down, i.e., the lack of Augmenter of Liver Regeneration, modifies the expression of genes involved in cell apoptosis and inhibits early phase of DNA synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008083 growth factor activity;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0071222 cellular response to lipopolysaccharide;GO:0097237 cellular response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63042-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63055-1", "uniprot_id": [ { "id": "ARFRP_RAT", "url": "https://www.uniprot.org/uniprot/Q63055", "type": "external" } ], "mass": 22659.0, "length": 201, "protein_name": "ADP-ribosylation factor-related protein 1", "gene_name": "Arfrp1", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-related protein 1 isoform 1", "refseq_ac": [ { "id": "NP_446432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446432", "type": "external" } ], "gene_names_uniprotkb": "Arfrp1; Arp1", "gene_names_refseq": "Arfrp1", "protein_names_uniprotkb": "ADP-ribosylation factor-related protein 1; ARF-related protein 1; ARP", "protein_names_refseq": "ADP-ribosylation factor related protein 1; ADP-ribosylation factor-related protein 1 isoform 1; ARP", "tax_id": 10116, "disease": "", "pathway": " (rno:117051); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8530503", "class_list": "", "function": "Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0043001 Golgi to plasma membrane protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0007369 gastrulation;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63055-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63073-1", "uniprot_id": [ { "id": "BTG1_RAT", "url": "https://www.uniprot.org/uniprot/Q63073", "type": "external" } ], "mass": 19195.0, "length": 171, "protein_name": "Protein BTG1", "gene_name": "Btg1", "organism": "Rat", "refseq_name": "protein BTG1", "refseq_ac": [ { "id": "NP_058954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058954", "type": "external" } ], "gene_names_uniprotkb": "Btg1", "gene_names_refseq": "Btg1", "protein_names_uniprotkb": "Protein BTG1; Anti-proliferative factor; B-cell translocation gene 1 protein", "protein_names_refseq": "B-cell translocation gene 1 protein; B-cell translocation gene 1, anti-proliferative; anti-proliferative factor; protein BTG1", "tax_id": 10116, "disease": "protein-energy malnutrition (Disease Ontology:DOID:11801); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:29618)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19359386;37062247;7588335", "class_list": "", "function": "Anti-proliferative protein., [UniProtKB]; Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest., [RefSeq, PubMed]; Overexpression of BTG1 or BTG2 arrested granulosa cells at the G0/G1 phase of the cell cycle and decreased cell apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0045766 positive regulation of angiogenesis;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63073-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63088-1", "uniprot_id": [ { "id": "CATJ_RAT", "url": "https://www.uniprot.org/uniprot/Q63088", "type": "external" } ], "mass": 36783.0, "length": 334, "protein_name": "Cathepsin J", "gene_name": "Ctsj", "organism": "Rat", "refseq_name": "cathepsin J precursor", "refseq_ac": [ { "id": "NP_058817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058817", "type": "external" } ], "gene_names_uniprotkb": "Ctsj; Ctsp", "gene_names_refseq": "Ctsj; Ctsp", "protein_names_uniprotkb": "Cathepsin J; 3.4.22.-; Cathepsin L-related protein; Cathepsin P; Catlrp-p", "protein_names_refseq": "cathepsin J precursor; cathepsin L-related protein; cathepsin P; catlrp-p", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29174)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19346238;7766407", "class_list": "", "function": "Results indicate a potential role of cathepsin P in processing and secretion of calreticulin during differentiation of trophoblast giant cells., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q920D9", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63088-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63117-1", "uniprot_id": [ { "id": "CLK3_RAT", "url": "https://www.uniprot.org/uniprot/Q63117", "type": "external" } ], "mass": 58485.0, "length": 490, "protein_name": "Dual specificity protein kinase CLK3", "gene_name": "Clk3", "organism": "Rat", "refseq_name": "dual specificity protein kinase CLK3", "refseq_ac": [ { "id": "NP_599167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599167", "type": "external" } ], "gene_names_uniprotkb": "Clk3", "gene_names_refseq": "Clk3", "protein_names_uniprotkb": "Dual specificity protein kinase CLK3; 2.7.12.1; CDC-like kinase 3", "protein_names_refseq": "dual specificity protein kinase CLK3", "tax_id": 10116, "disease": "", "pathway": " (rno:171305)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;38438604;8679717", "class_list": "", "function": "CDC-like kinase 3 deficiency aggravates hypoxia-induced cardiomyocyte apoptosis through AKT signaling pathway., [RefSeq, PubMed]; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRK2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0046777 protein autophosphorylation;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63117-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63118-1", "uniprot_id": [ { "id": "CALRL_RAT", "url": "https://www.uniprot.org/uniprot/Q63118", "type": "external" } ], "mass": 53329.0, "length": 464, "protein_name": "Calcitonin gene-related peptide type 1 receptor", "gene_name": "Calcrl", "organism": "Rat", "refseq_name": "calcitonin gene-related peptide type 1 receptor isoform X1", "refseq_ac": [ { "id": "XP_006234501", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006234501", "type": "external" } ], "gene_names_uniprotkb": "Calcrl; Cgrpr", "gene_names_refseq": "CLR; Calcrl; Crlr; RATCRLR; RNCLR", "protein_names_uniprotkb": "Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor", "protein_names_refseq": "calcitonin gene-related peptide type 1 receptor isoform X1", "tax_id": 10116, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (rno:25029); (R-RNO-419812); (R-RNO-9856530)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8222502", "class_list": "", "function": "G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004948 calcitonin receptor activity;GO:0001605 adrenomedullin receptor activity;GO:0001635 calcitonin gene-related peptide receptor activity;GO:1990409 adrenomedullin binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63118-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63159-1", "uniprot_id": [ { "id": "COQ3_RAT", "url": "https://www.uniprot.org/uniprot/Q63159", "type": "external" } ], "mass": 38708.0, "length": 345, "protein_name": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "gene_name": "Coq3", "organism": "Rat", "refseq_name": "ubiquinone biosynthesis O-methyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_062060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062060", "type": "external" } ], "gene_names_uniprotkb": "Coq3", "gene_names_refseq": "Coq3", "protein_names_uniprotkb": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial; 2.1.1.-; 2.1.1.114; 2.1.1.64; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; Polyprenyldihydroxybenzoate methyltransferase", "protein_names_refseq": "2-polyprenyl-6-hydroxyphenol methylase; 2-polyprenyl-6-hydroxyphenyl methylase; 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; 3-demethylubiquinone-9 3-methyltransferase; DHHB methyltransferase; DHHB-MTase; DHHB-MT; coenzyme Q (ubiquinone); coenzyme Q3 homolog, methyltransferase; dihydroxyhexaprenylbenzoate methyltransferase; hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; polyprenyldihydroxybenzoate methyltransferase; ubiquinone biosynthesis O-methyltransferase, mitochondrial", "tax_id": 10116, "disease": "spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (rno:29309); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8125303", "class_list": "", "function": "O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN24;Q642D7", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008171 O-methyltransferase activity;GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity;GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity;GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0006071 glycerol metabolic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63198-1", "uniprot_id": [ { "id": "CNTN1_RAT", "url": "https://www.uniprot.org/uniprot/Q63198", "type": "external" } ], "mass": 113495.0, "length": 1021, "protein_name": "Contactin-1", "gene_name": "Cntn1", "organism": "Rat", "refseq_name": "contactin-1 precursor", "refseq_ac": [ { "id": "NP_476459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476459", "type": "external" } ], "gene_names_uniprotkb": "Cntn1", "gene_names_refseq": "Cntn1; F3", "protein_names_uniprotkb": "Contactin-1; Neural cell surface protein F3", "protein_names_refseq": "contactin-1 precursor; neural cell surface protein F3", "tax_id": 10116, "disease": "Compton-North congenital myopathy (Disease Ontology:DOID:0080101)", "pathway": " (rno:117258)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1039/D0MO00044B;20451518;24090084;34106099;38843836;7628014;7777204;9081628;9118959;9396755", "class_list": "", "function": "Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth., [UniProtKB, PubMed]; Expression of alternatively spliced FnIII domains of tenascin-C is differentially regulated after brain injury, with strong increases of domains B and D that may well influence axonal regeneration and repair processes in the damaged nervous system., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 4, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 34, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0032289 central nervous system myelin formation;GO:0007219 Notch signaling pathway;GO:0007626 locomotory behavior;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "Q63198-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63315-1", "uniprot_id": [ { "id": "CAD22_RAT", "url": "https://www.uniprot.org/uniprot/Q63315", "type": "external" } ], "mass": 87979.0, "length": 813, "protein_name": "Cadherin-22", "gene_name": "Cdh22", "organism": "Rat", "refseq_name": "cadherin-22 precursor", "refseq_ac": [ { "id": "NP_062034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062034", "type": "external" } ], "gene_names_uniprotkb": "Cdh22", "gene_names_refseq": "Cdh22", "protein_names_uniprotkb": "Cadherin-22; PB-cadherin; Pituitary and brain cadherin", "protein_names_refseq": "PB-cadherin; cadherin-22 precursor; pituitary and brain cadherin", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); hereditary coproporphyria (Disease Ontology:DOID:13269); cancer (Disease Ontology:DOID:162); liver disease (Disease Ontology:DOID:409)", "pathway": " (rno:29182)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16038895;17187413;8626716", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues., [UniProtKB]; PB-cadherin promotes survival of spermatocytes and activates Jak2 and Stat3 signalling., [RefSeq, PubMed]; We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp)., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63561", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63315-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63474-1", "uniprot_id": [ { "id": "DDR1_RAT", "url": "https://www.uniprot.org/uniprot/Q63474", "type": "external" } ], "mass": 101165.0, "length": 910, "protein_name": "Epithelial discoidin domain-containing receptor 1", "gene_name": "Ddr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddr1; Eddr1; Ptk3", "gene_names_refseq": "", "protein_names_uniprotkb": "Epithelial discoidin domain-containing receptor 1; 2.7.10.1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; Epithelial discoidin domain receptor 1; Protein-tyrosine kinase 3; Tyrosine kinase DDR; Tyrosine-protein kinase CAK", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); coronin-1A deficiency (Disease Ontology:DOID:0060019); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014); alcoholic hepatitis (Disease Ontology:DOID:12351); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25678); (R-RNO-3000171)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8127887", "class_list": "", "function": "Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0038062 protein tyrosine kinase collagen receptor activity;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0061302 smooth muscle cell-matrix adhesion;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63474-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63514-1", "uniprot_id": [ { "id": "C4BPA_RAT", "url": "https://www.uniprot.org/uniprot/Q63514", "type": "external" } ], "mass": 62266.0, "length": 558, "protein_name": "C4b-binding protein alpha chain", "gene_name": "C4bpa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C4bpa", "gene_names_refseq": "", "protein_names_uniprotkb": "C4b-binding protein alpha chain; C4bp", "protein_names_refseq": "", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9013975", "class_list": "", "function": "Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It also interacts with anticoagulant protein S and with serum amyloid P component., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001848 complement binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0001669 acrosomal vesicle;GO:0044297 cell body", "go_biological_process": "GO:0009609 response to symbiotic bacterium;GO:0006955 immune response;GO:0007339 binding of sperm to zona pellucida;GO:0045087 innate immune response;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63514-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63515-1", "uniprot_id": [ { "id": "C4BPB_RAT", "url": "https://www.uniprot.org/uniprot/Q63515", "type": "external" } ], "mass": 28642.0, "length": 258, "protein_name": "C4b-binding protein beta chain", "gene_name": "C4bpb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C4bpb", "gene_names_refseq": "", "protein_names_uniprotkb": "C4b-binding protein beta chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 128 (Disease Ontology:DOID:0061093); COVID-19 (Disease Ontology:DOID:0080600); combined immunodeficiency (Disease Ontology:DOID:0111962); polyclonal hypergammaglobulinemia (Disease Ontology:DOID:2344)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9013975", "class_list": "", "function": "Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0009609 response to symbiotic bacterium;GO:0045087 innate immune response;GO:0045732 positive regulation of protein catabolic process;GO:0045959 negative regulation of complement activation, classical pathway;GO:1903027 regulation of opsonization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63515-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63619-1", "uniprot_id": [ { "id": "COQ7_RAT", "url": "https://www.uniprot.org/uniprot/Q63619", "type": "external" } ], "mass": 23870.0, "length": 217, "protein_name": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial", "gene_name": "Coq7", "organism": "Rat", "refseq_name": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial", "refseq_ac": [ { "id": "NP_036917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036917", "type": "external" } ], "gene_names_uniprotkb": "Coq7", "gene_names_refseq": "Coq7", "protein_names_uniprotkb": "NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial; 1.14.13.253; 3-demethoxyubiquinone 3-hydroxylase (NADH); Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7", "protein_names_refseq": "3-demethoxyubiquinone 3-hydroxylase (NADH); 5-demethoxyubiquinone hydroxylase, mitochondrial; Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7; DMQ hydroxylase; NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial; coenzyme Q biosynthesis protein 7 homolog; coenzyme Q7 homolog, ubiquinone; demethyl-Q 7; timing protein clk-1 homolog; ubiquinone biosynthesis monooxygenase COQ7; ubiquinone biosynthesis protein COQ7 homolog", "tax_id": 10116, "disease": "primary coenzyme Q10 deficiency 8 (Disease Ontology:DOID:0070245); autosomal recessive distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0081428)", "pathway": " (rno:25249); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22196358;8660658", "class_list": "", "function": "Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone. Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. The binding of 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation. The physiological substrates are 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (By similarity)., [UniProtKB, UniProtKB, HAMAP]; GroEL gene encodes a protein of 60 kDa with a high degree of homology (99% similarity) to those of other leptospiral serovar, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V879;O08887", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0160224 3-demethoxyubiquinone 3-hydroxylase (NADH) activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006979 response to oxidative stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63619-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63691-1", "uniprot_id": [ { "id": "CD14_RAT", "url": "https://www.uniprot.org/uniprot/Q63691", "type": "external" } ], "mass": 40054.0, "length": 372, "protein_name": "Monocyte differentiation antigen CD14", "gene_name": "Cd14", "organism": "Rat", "refseq_name": "monocyte differentiation antigen CD14 precursor", "refseq_ac": [ { "id": "NP_068512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068512", "type": "external" } ], "gene_names_uniprotkb": "Cd14", "gene_names_refseq": "Cd14", "protein_names_uniprotkb": "Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein", "protein_names_refseq": "CD14 antigen; monocyte differentiation antigen CD14 precursor; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Hirschsprung's disease (Disease Ontology:DOID:10487); celiac disease (Disease Ontology:DOID:10608); hypertension (Disease Ontology:DOID:10763); sarcoidosis (Disease Ontology:DOID:11335); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); cholestasis (Disease Ontology:DOID:13580); obstructive jaundice (Disease Ontology:DOID:13603); biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); carotid artery disease (Disease Ontology:DOID:3407); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); periodontitis (Disease Ontology:DOID:824); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:60350); (R-RNO-140534); (R-RNO-166016); (R-RNO-166020); (R-RNO-166166); (R-RNO-2562578); (R-RNO-5686938); (R-RNO-6798695); (R-RNO-936964); (R-RNO-937041); (R-RNO-937072); (R-RNO-975163); (R-RNO-9824878)", "pathway_count": 13, "publication_count": 7, "publication_id_list": "25093541;27816522;33249861;35070875;8598386;9201265;9784508", "class_list": "", "function": "CD 14 mRNA expression increased significantly after five days of bile duct ligation in liver, lung, spleen, and ileum., [RefSeq, PubMed]; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury., [RefSeq, PubMed]; Study of the effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat liver., [RefSeq, PubMed]; This study shows that sCD14 impairs contractile function and insulin action in primary adult rat cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6GT04", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0070891 lipoteichoic acid binding;GO:0001875 lipopolysaccharide immune receptor activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0045087 innate immune response;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63691-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63764-1", "uniprot_id": [ { "id": "AZIN1_RAT", "url": "https://www.uniprot.org/uniprot/Q63764", "type": "external" } ], "mass": 49333.0, "length": 448, "protein_name": "Antizyme inhibitor 1", "gene_name": "Azin1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Azin1; Oazin; Oazi", "gene_names_refseq": "", "protein_names_uniprotkb": "Antizyme inhibitor 1; AZI; Ornithine decarboxylase antizyme inhibitor", "protein_names_refseq": "", "tax_id": 10116, "disease": "pneumocystosis (Disease Ontology:DOID:11339); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:58961); (R-RNO-350562)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2713421;8631929;9349715", "class_list": "", "function": "Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042978 ornithine decarboxylase activator activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0042177 negative regulation of protein catabolic process;GO:0044849 estrous cycle;GO:0050679 positive regulation of epithelial cell proliferation;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:1902269 positive regulation of polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641W9-1", "uniprot_id": [ { "id": "ACL7A_RAT", "url": "https://www.uniprot.org/uniprot/Q641W9", "type": "external" } ], "mass": 49568.0, "length": 440, "protein_name": "Actin-like protein 7A", "gene_name": "Actl7a", "organism": "Rat", "refseq_name": "actin-like protein 7A", "refseq_ac": [ { "id": "NP_001011973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011973", "type": "external" } ], "gene_names_uniprotkb": "Actl7a", "gene_names_refseq": "Actl7a; Arp7a; T-actin 2; Tact2", "protein_names_uniprotkb": "Actin-like protein 7A", "protein_names_refseq": "actin-like protein 7A", "tax_id": 10116, "disease": "spermatogenic failure 86 (Disease Ontology:DOID:0070585); male infertility (Disease Ontology:DOID:12336); bladder urothelial carcinoma (Disease Ontology:DOID:4006)", "pathway": " (rno:298017)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21278383", "class_list": "", "function": "Essential for normal spermatogenesis and male fertility. Required for normal sperm head morphology, acroplaxome formation, acrosome attachment, and acrosome granule stability. May anchor and stabilize acrosomal adherence to the acroplaxome at least in part by facilitating the presence of F-actin in the subacrosomal space. May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis., [UniProtKB, UniProtKB]; Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0031514 motile cilium", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641W9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y1-1", "uniprot_id": [ { "id": "C56D2_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y1", "type": "external" } ], "mass": 24124.0, "length": 222, "protein_name": "Transmembrane reductase CYB561D2", "gene_name": "Cyb561d2", "organism": "Rat", "refseq_name": "transmembrane reductase CYB561D2", "refseq_ac": [ { "id": "NP_001007754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007754", "type": "external" } ], "gene_names_uniprotkb": "Cyb561d2", "gene_names_refseq": "Cyb561d2", "protein_names_uniprotkb": "Transmembrane reductase CYB561D2; 7.2.1.3; Cytochrome b561 domain-containing protein 2", "protein_names_refseq": "cytochrome b-561 domain containing 2; cytochrome b561 domain-containing protein 2; putative tumor suppressor protein 101F6; transmembrane ascorbate ferrireductase; transmembrane reductase CYB561D2", "tax_id": 10116, "disease": "", "pathway": " (rno:363137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane reductase that may use ascorbate as an electron donor in the cytoplasm and transfer electrons across endoplasmic reticulum membranes to reduce monodehydro-L-ascorbate radical and iron cations Fe(3+) in the lumen of that compartment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0140575 transmembrane monodehydroascorbate reductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031982 vesicle", "go_biological_process": "GO:0140576 ascorbate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641Y1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y5-1", "uniprot_id": [ { "id": "ATG7_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y5", "type": "external" } ], "mass": 77436.0, "length": 698, "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "Atg7", "organism": "Rat", "refseq_name": "ubiquitin-like modifier-activating enzyme ATG7", "refseq_ac": [ { "id": "NP_001012097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012097", "type": "external" } ], "gene_names_uniprotkb": "Atg7; Apg7l", "gene_names_refseq": "Apg7l; Atg7", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme ATG7; APG7-like; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7", "protein_names_refseq": "ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog; autophagy 7-like; autophagy-related protein 7; ubiquitin-activating enzyme E1-like protein; ubiquitin-like modifier-activating enzyme ATG7", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); cardiac arrest (Disease Ontology:DOID:0060319); autosomal recessive spinocerebellar ataxia 31 (Disease Ontology:DOID:0070412); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); high grade glioma (Disease Ontology:DOID:3070); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); nervous system disease (Disease Ontology:DOID:863); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:312647); (R-RNO-1632852); (R-RNO-6798695); (R-RNO-983168)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11890701;24187137;37059928;37815664;37964653", "class_list": "", "function": "E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Facilitates LC3-I lipidation with phosphatidylethanolamine to form LC3-II which is found on autophagosomal membranes (By similarity). Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Also plays a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation (By similarity). Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism., [RefSeq, PubMed]; METTL3-mediated maturation of miR-192-5p targets ATG7 to prevent Schwann cell autophagy in peripheral nerve injury., [RefSeq, PubMed]; Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0019778 Atg12 activating enzyme activity;GO:0019779 Atg8 activating enzyme activity;GO:0008641 ubiquitin-like modifier activating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm;GO:0005930 axoneme;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0097305 response to alcohol;GO:0061684 chaperone-mediated autophagy;GO:0099504 synaptic vesicle cycle;GO:1901526 positive regulation of mitophagy;GO:0000045 autophagosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q641Y5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z7-1", "uniprot_id": [ { "id": "ASM3A_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z7", "type": "external" } ], "mass": 49896.0, "length": 445, "protein_name": "Cyclic GMP-AMP phosphodiesterase SMPDL3A", "gene_name": "Smpdl3a", "organism": "Rat", "refseq_name": "cyclic GMP-AMP phosphodiesterase SMPDL3A precursor", "refseq_ac": [ { "id": "NP_001005539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005539", "type": "external" } ], "gene_names_uniprotkb": "Smpdl3a; Asml3a", "gene_names_refseq": "Smpdl3a", "protein_names_uniprotkb": "Cyclic GMP-AMP phosphodiesterase SMPDL3A; 2',3'-cGAMP phosphodiesterase SMPDL3A; 3.1.4.-; 3.6.1.15; ASM-like phosphodiesterase 3a; Acid sphingomyelinase-like phosphodiesterase 3a", "protein_names_refseq": "2',3'-cGAMP phosphodiesterase SMPDL3A; ASM-like phosphodiesterase 3a; acid sphingomyelinase-like phosphodiesterase 3A; cyclic GMP-AMP phosphodiesterase SMPDL3A precursor; cyclic GMP-AMP phosphodiesterase SMPDL3A", "tax_id": 10116, "disease": "", "pathway": " (rno:294422)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19926744", "class_list": "", "function": "Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity., [UniProtKB, UniProtKB]; Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0009143 nucleoside triphosphate catabolic process;GO:0160049 negative regulation of cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641Z7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64240-1", "uniprot_id": [ { "id": "AMBP_RAT", "url": "https://www.uniprot.org/uniprot/Q64240", "type": "external" } ], "mass": 38851.0, "length": 349, "protein_name": "Protein AMBP", "gene_name": "Ambp", "organism": "Rat", "refseq_name": "protein AMBP isoform 2 precursor", "refseq_ac": [ { "id": "NP_037033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037033", "type": "external" } ], "gene_names_uniprotkb": "Ambp; Itil", "gene_names_refseq": "Ambp; UTI", "protein_names_uniprotkb": "Protein AMBP; Bikunin; HI-30", "protein_names_refseq": "Alpha-1 microglobulin/bikunin; alpha 1 microglobulin/bikunin; protein AMBP isoform 2 precursor; protein AMBP; ulinastatin; urinary trypsin inhibitor", "tax_id": 10116, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pyelonephritis (Disease Ontology:DOID:11400); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (rno:25377); (R-RNO-2168880)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1371936;21454685;2429963;3263966;7508921;7519849", "class_list": "", "function": "Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments. Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis. Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential. Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage. Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures. Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation. Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria. Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (By similarity). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Kunitz-type serine protease inhibitor and structural component of extracellular matrix with a role in extracellular space remodeling and cell adhesion. Among others, has antiprotease activity toward kallikrein, a protease involved in airway inflammation; inhibits GZMK/granzyme, a granule-stored serine protease involved in NK and T cell cytotoxic responses; and inhibits PLG/plasmin, a protease required for activation of matrix metalloproteinases. As part of I-alpha-I complex, provides for the heavy chains to be transferred from I-alpha-I complex to hyaluronan in the presence of TNFAIP6, in a dynamic process that releases free bikunin and remodels extracellular matrix proteoglycan structures. Free bikunin, but not its heavy chain-bound form, acts as a potent protease inhibitor in airway secretions (By similarity). Part of hyaluronan-rich extracellular matrix that surrounds oocyte during cumulus oophorus expansion, an indispensable process for proper ovulation (By similarity). Also inhibits calcium oxalate crystallization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P19603;Q63336", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042803 protein homodimerization activity;GO:0030246 carbohydrate binding;GO:0016209 antioxidant activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0020027 hemoglobin metabolic process;GO:0030163 protein catabolic process;GO:0034614 cellular response to reactive oxygen species;GO:0098869 cellular oxidant detoxification;GO:1903606 cytochrome c metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64240-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64244-1", "uniprot_id": [ { "id": "CD38_RAT", "url": "https://www.uniprot.org/uniprot/Q64244", "type": "external" } ], "mass": 34436.0, "length": 303, "protein_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "gene_name": "Cd38", "organism": "Rat", "refseq_name": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1", "refseq_ac": [ { "id": "NP_037259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037259", "type": "external" } ], "gene_names_uniprotkb": "Cd38", "gene_names_refseq": "ADPRC 1; Cd38", "protein_names_uniprotkb": "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; 2.4.99.20; 3.2.2.-; 3.2.2.6; ADP-ribosyl cyclase 1; ADPRC 1; CD38H; Cyclic ADP-ribose hydrolase 1; cADPR hydrolase 1", "protein_names_refseq": "2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38H; cADPr hydrolase 1; cyclic ADP-ribose hydrolase 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); morbid obesity (Disease Ontology:DOID:11981); atherosclerosis (Disease Ontology:DOID:1936); glioblastoma (Disease Ontology:DOID:3068); coronary artery disease (Disease Ontology:DOID:3393); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25668); (R-RNO-196807)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10477767;11829748;24090084;28296029;29187364;29393594;32507768;34364851;36490326;8037769;8061050", "class_list": "", "function": "CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD(+)/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats., [RefSeq, PubMed]; CD38 plays an essential role in cardiac hypertrophy probably via inhibition of SIRT3 expression and activation of Ca(2+) -NFAT signaling pathway., [RefSeq, PubMed]; Downregulation of Sirt6 by CD38 promotes cell senescence and aging., [RefSeq, PubMed]; Endothelial cells have high expression of CD38 which is activated by hypoxia-reoxygenation triggering CD38-mediated NADP(H) depletion with loss of eNOS-mediated NO generation and increased eNOS uncoupling., [RefSeq, PubMed]; Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid (PubMed:11829748). At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. Functions also as a receptor that binds the ligand CD31 on endothelial cells, promoting lymphocyte activation, proliferation, and migration across the endothelial barrier. Involved in the regulation of crucial dendritic cell functions acquired at the mature stage, such as CCL21-driven migration, survival, and Th1-polarizing activity. In lamina propria T lymphocytes, CD38/CD31 cognate interactions initiate a multistep signaling pathway resulting in activation of LCK anf LAT, followed by cytokine release., [UniProtKB, UniProtKB, PubMed]; Oxytocin attenuates schizophrenia-like reduced sensorimotor gating in outbred and inbred rats in line with strain differences in CD38 gene expression., [RefSeq, PubMed]; Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016740 transferase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0016849 phosphorus-oxygen lyase activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0032024 positive regulation of insulin secretion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q64244-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64541-1", "uniprot_id": [ { "id": "AT1A4_RAT", "url": "https://www.uniprot.org/uniprot/Q64541", "type": "external" } ], "mass": 114005.0, "length": 1028, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-4", "gene_name": "Atp1a4", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-4 isoform 1", "refseq_ac": [ { "id": "NP_001257959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257959", "type": "external" } ], "gene_names_uniprotkb": "Atp1a4; Atp1al2", "gene_names_refseq": "Atp1a4", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-4; 7.2.2.13; Na(+)/K(+) ATPase alpha-4 subunit; Sodium pump subunit alpha-4", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 4 polypeptide; Na(+)/K(+) ATPase alpha-4 subunit; sodium pump subunit alpha-4; sodium/potassium-transporting ATPase subunit alpha-4 isoform 1; sodium/potassium-transporting ATPase subunit alpha-4-like; sodium/potassium-transporting ATPase subunit alpha-4", "tax_id": 10116, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:29132); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12763881;20179187;22441762;26476261;27599714;38843836;7809153", "class_list": "", "function": "Atp1a4 is tuned for changing extracellular environments during sperm capacitation., [RefSeq, PubMed]; Na,K-ATPase alpha4 activity is up-regulated during sperm capacitation through mechanisms that involve both increases in molecular activity and levels of alpha4 at the sperm plasma membrane., [RefSeq, PubMed]; Ouabain interactions with the alpha4 isoform of the sodium pump trigger non-classical steroid hormone signaling and integrin expression in spermatocytes., [RefSeq, PubMed]; Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:20179187). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (PubMed:20179187)., [UniProtKB, PubMed]; This isoform is developmentally expressed in haploid and diploid spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005886 plasma membrane;GO:0042995 cell projection;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0097225 sperm midpiece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0042391 regulation of membrane potential;GO:0030317 flagellated sperm motility;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64541-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64563-1", "uniprot_id": [ { "id": "ADH4_RAT", "url": "https://www.uniprot.org/uniprot/Q64563", "type": "external" } ], "mass": 40277.0, "length": 377, "protein_name": "All-trans-retinol dehydrogenase [NAD(+)] ADH4", "gene_name": "Adh4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adh4; Adh2", "gene_names_refseq": "", "protein_names_uniprotkb": "All-trans-retinol dehydrogenase [NAD(+)] ADH4; 1.1.1.105; Alcohol dehydrogenase 2; Alcohol dehydrogenase 4; Alcohol dehydrogenase II; Alcohol dehydrogenase class II", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (R-RNO-5365859); (R-RNO-71384)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17279314;7635195", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Also catalyzes the reduction of benzoquinones (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.284", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.284", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0008270 zinc ion binding;GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity;GO:0003960 quinone reductase (NADPH) activity;GO:0004032 aldose reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0045471 response to ethanol;GO:0046294 formaldehyde catabolic process;GO:0006066 alcohol metabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64563-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64565-1", "uniprot_id": [ { "id": "AGT2_RAT", "url": "https://www.uniprot.org/uniprot/Q64565", "type": "external" } ], "mass": 57201.0, "length": 512, "protein_name": "Alanine--glyoxylate aminotransferase 2, mitochondrial", "gene_name": "Agxt2", "organism": "Rat", "refseq_name": "alanine--glyoxylate aminotransferase 2, mitochondrial", "refseq_ac": [ { "id": "NP_114023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114023", "type": "external" } ], "gene_names_uniprotkb": "Agxt2; Agt2", "gene_names_refseq": "AGT2; Agxt2", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase 2, mitochondrial; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.18; 2.6.1.40; 2.6.1.44; AGT 2; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase", "protein_names_refseq": "(R)-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase; alanine--glyoxylate aminotransferase 2, mitochondrial; beta-ALAAT II; beta-alanine-pyruvate aminotransferase", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); mild cognitive impairment (Disease Ontology:DOID:0080832); hypertension (Disease Ontology:DOID:10763); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); intermittent claudication (Disease Ontology:DOID:3669); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:83784); (R-RNO-389661)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10989446;2123486;2393662;36735737;6803844;7592550", "class_list": "", "function": "Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional aminotransferase with a broad substrate specificity (PubMed:10989446, PubMed:2123486, PubMed:2393662, PubMed:6803844). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (PubMed:2123486, PubMed:6803844). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:10989446, PubMed:2393662, PubMed:6803844). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (PubMed:10989446). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:2123486). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08616;Q642F1", "ec_number_list": [ { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.6.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.40", "type": "external" }, { "id": "2.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008453 alanine-glyoxylate transaminase activity;GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity;GO:0016223 beta-alanine:pyruvate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0009436 glyoxylate catabolic process;GO:0019265 glycine biosynthetic process, by transamination of glyoxylate;GO:0019481 L-alanine catabolic process, by transamination;GO:2001299 N(omega),N(omega)-dimethyl-L-arginine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H02-1", "uniprot_id": [ { "id": "CENPQ_RAT", "url": "https://www.uniprot.org/uniprot/Q66H02", "type": "external" } ], "mass": 31002.0, "length": 270, "protein_name": "Centromere protein Q", "gene_name": "Cenpq", "organism": "Rat", "refseq_name": "centromere protein Q isoform 2", "refseq_ac": [ { "id": "NP_001014237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014237", "type": "external" } ], "gene_names_uniprotkb": "Cenpq; AABR07066944.1", "gene_names_refseq": "Cenpq", "protein_names_uniprotkb": "Centromere protein Q; CENP-Q", "protein_names_refseq": "CENP-Q; centromere protein Q isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363198); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:1905342 positive regulation of protein localization to kinetochore", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H02-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H21-1", "uniprot_id": [ { "id": "CHPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H21", "type": "external" } ], "mass": 44601.0, "length": 398, "protein_name": "Cholinephosphotransferase 1", "gene_name": "Chpt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chpt1; Cpt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cholinephosphotransferase 1; 2.7.8.2; Diacylglycerol cholinephosphotransferase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinal disease (Disease Ontology:DOID:5679)", "pathway": " (R-RNO-1483191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0006656 phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H21-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H24-1", "uniprot_id": [ { "id": "CI040_RAT", "url": "https://www.uniprot.org/uniprot/Q66H24", "type": "external" } ], "mass": 18149.0, "length": 166, "protein_name": "Uncharacterized protein C9orf40 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C9orf40 homolog", "refseq_ac": [ { "id": "NP_001019464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019464", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C1h9orf40", "protein_names_uniprotkb": "Uncharacterized protein C9orf40 homolog", "protein_names_refseq": "uncharacterized protein C9orf40 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:499331)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H33-1", "uniprot_id": [ { "id": "CC038_RAT", "url": "https://www.uniprot.org/uniprot/Q66H33", "type": "external" } ], "mass": 39582.0, "length": 348, "protein_name": "Uncharacterized protein C3orf38 homolog", "gene_name": "C11h3orf38; Cxh3orf38", "organism": "Rat", "refseq_name": "uncharacterized protein C3orf38 homolog", "refseq_ac": [ { "id": "NP_001005552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005552", "type": "external" } ], "gene_names_uniprotkb": "C11h3orf38; Cxh3orf38; Cxh3orf38; LOC100362724; MGC95208", "gene_names_refseq": "C11h3orf38", "protein_names_uniprotkb": "Uncharacterized protein C3orf38 homolog", "protein_names_refseq": "uncharacterized protein C3orf38 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100362724); (rno:304176)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in apoptosis regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H33-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H43-1", "uniprot_id": [ { "id": "BORC6_RAT", "url": "https://www.uniprot.org/uniprot/Q66H43", "type": "external" } ], "mass": 37828.0, "length": 360, "protein_name": "BLOC-1-related complex subunit 6", "gene_name": "Borcs6", "organism": "Rat", "refseq_name": "BLOC-1-related complex subunit 6", "refseq_ac": [ { "id": "NP_001017474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017474", "type": "external" } ], "gene_names_uniprotkb": "Borcs6", "gene_names_refseq": "Borcs6", "protein_names_uniprotkb": "BLOC-1-related complex subunit 6", "protein_names_refseq": "BLOC-1-related complex subunit 6; uncharacterized protein C17orf59 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:497934)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0099078 BORC complex", "go_biological_process": "GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H80-1", "uniprot_id": [ { "id": "COPD_RAT", "url": "https://www.uniprot.org/uniprot/Q66H80", "type": "external" } ], "mass": 57199.0, "length": 511, "protein_name": "Coatomer subunit delta", "gene_name": "Arcn1", "organism": "Rat", "refseq_name": "coatomer subunit delta", "refseq_ac": [ { "id": "NP_001007663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007663", "type": "external" } ], "gene_names_uniprotkb": "Arcn1; Copd", "gene_names_refseq": "Arcn1", "protein_names_uniprotkb": "Coatomer subunit delta; Archain; Delta-COP; Delta-coat protein", "protein_names_refseq": "coatomer subunit delta; delta-COP; delta-coat protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300674); (R-RNO-6807878); (R-RNO-6811434)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16476741", "class_list": "", "function": "NCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP, [RefSeq, PubMed]; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030137 COPI-coated vesicle;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0043473 pigmentation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H80-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H85-1", "uniprot_id": [ { "id": "ANKZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H85", "type": "external" } ], "mass": 80585.0, "length": 722, "protein_name": "tRNA endonuclease ANKZF1", "gene_name": "Ankzf1", "organism": "Rat", "refseq_name": "tRNA endonuclease ANKZF1", "refseq_ac": [ { "id": "NP_001014241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014241", "type": "external" } ], "gene_names_uniprotkb": "Ankzf1", "gene_names_refseq": "Ankzf1; RGD1359242", "protein_names_uniprotkb": "tRNA endonuclease ANKZF1; 3.1.-.-; Ankyrin repeat and zinc finger domain-containing protein 1", "protein_names_refseq": "ankyrin repeat and zinc finger domain containing 1; ankyrin repeat and zinc finger domain-containing protein 1; ankyrin repeat containing protein RGD1359242; tRNA endonuclease ANKZF1", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (rno:363255)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity;GO:0140101 catalytic activity, acting on a tRNA;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0070301 cellular response to hydrogen peroxide;GO:0036503 ERAD pathway;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H85-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H96-1", "uniprot_id": [ { "id": "CABP7_RAT", "url": "https://www.uniprot.org/uniprot/Q66H96", "type": "external" } ], "mass": 24453.0, "length": 215, "protein_name": "Calcium-binding protein 7", "gene_name": "Cabp7", "organism": "Rat", "refseq_name": "calcium-binding protein 7", "refseq_ac": [ { "id": "NP_001007731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007731", "type": "external" } ], "gene_names_uniprotkb": "Cabp7; Caln2", "gene_names_refseq": "Cabp7; rCaBP7", "protein_names_uniprotkb": "Calcium-binding protein 7; CaBP7; Calneuron II; Calneuron-2", "protein_names_refseq": "calcium-binding protein 7; calneuron-2; calneuron-II", "tax_id": 10116, "disease": "", "pathway": " (rno:360970)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17055077;19458041", "class_list": "", "function": "Calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking., [RefSeq, PubMed]; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity., [UniProtKB, PubMed]; The calcium sensor protein caldendrin is abundantly expressed in neurons and is thought to play an important role in different aspects of synapto-dendritic Ca2+ signaling. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0007528 neuromuscular junction development;GO:0060537 muscle tissue development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HB6-1", "uniprot_id": [ { "id": "CAGE1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HB6", "type": "external" } ], "mass": 97443.0, "length": 847, "protein_name": "Cancer-associated gene 1 protein homolog", "gene_name": "Cage1", "organism": "Rat", "refseq_name": "cancer-associated gene 1 protein homolog", "refseq_ac": [ { "id": "NP_001012052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012052", "type": "external" } ], "gene_names_uniprotkb": "Cage1; Ctag3", "gene_names_refseq": "Cage1; Ctag3", "protein_names_uniprotkb": "Cancer-associated gene 1 protein homolog; CAGE-1; CT3 homolog; Cancer/testis antigen 3 homolog", "protein_names_refseq": "CAGE-1; CT3 homolog; cancer-associated gene 1 protein homolog; cancer/testis antigen 3 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:306872)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HF0-1", "uniprot_id": [ { "id": "ARMX6_RAT", "url": "https://www.uniprot.org/uniprot/Q66HF0", "type": "external" } ], "mass": 33374.0, "length": 301, "protein_name": "Protein ARMCX6", "gene_name": "Armcx6", "organism": "Rat", "refseq_name": "protein ARMCX6", "refseq_ac": [ { "id": "NP_001007758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007758", "type": "external" } ], "gene_names_uniprotkb": "Armcx6", "gene_names_refseq": "Armcx6", "protein_names_uniprotkb": "Protein ARMCX6", "protein_names_refseq": "arm protein lost in epithelial cancers, X chromosome, 3; protein ARMCX6-like; protein ARMCX6", "tax_id": 10116, "disease": "", "pathway": " (rno:363496)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate the dynamics and distribution of mitochondria in neural cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HF0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG6-1", "uniprot_id": [ { "id": "CAH5B_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG6", "type": "external" } ], "mass": 36598.0, "length": 317, "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "Ca5b", "organism": "Rat", "refseq_name": "carbonic anhydrase 5B, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001005551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005551", "type": "external" } ], "gene_names_uniprotkb": "Ca5b; Car5b", "gene_names_refseq": "Ca5b; Car5b", "protein_names_uniprotkb": "Carbonic anhydrase 5B, mitochondrial; 4.2.1.1; CA-VB; Carbonate dehydratase VB; Carbonic anhydrase VB", "protein_names_refseq": "CA-VB; carbonate dehydratase VB; carbonic anhydrase 5B, mitochondrial isoform 1 precursor; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase VB, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:302669); (R-RNO-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3., [UniProtKB, UniProtKB]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FP3-1", "uniprot_id": [ { "id": "CCL6_RAT", "url": "https://www.uniprot.org/uniprot/Q68FP3", "type": "external" } ], "mass": 12652.0, "length": 115, "protein_name": "C-C motif chemokine 6", "gene_name": "Ccl6", "organism": "Rat", "refseq_name": "C-C motif chemokine 6 precursor", "refseq_ac": [ { "id": "NP_001004202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004202", "type": "external" } ], "gene_names_uniprotkb": "Ccl6", "gene_names_refseq": "Ccl6; Mrp-1; Scay6", "protein_names_uniprotkb": "C-C motif chemokine 6; Small-inducible cytokine A6", "protein_names_refseq": "C-C motif chemokine 6 precursor; C-C motif chemokine 6; chemokine (C-C motif) ligand 6; chemokine ligand 6; small-inducible cytokine A6", "tax_id": 10116, "disease": "", "pathway": " (rno:287910); (R-RNO-416476); (R-RNO-418594); (R-RNO-444473)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17218081;23212328;31551151;32833905", "class_list": "", "function": "Chemokine (C-C motif) Ligand 6 Aggravates Hypoxia Reoxygenation-induced Apoptosis in H9c2 Cells Through Enhancing the Expression of Insulin-like Growth Factor 2-Antisense., [RefSeq, PubMed]; Data suggest that astrocytes protect neurons by activating CCR1 in neurons. Moreover, this neuroprotective action of astrocyte CCL6 is mediated by CCR1, and downstream by PI3K, [RefSeq, PubMed]; The mouse C10 analog gene in the rat, and named it as ccl6, was identified and cloned. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1EC85;Q6IVB4", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q68FP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FQ4-1", "uniprot_id": [ { "id": "CF300_RAT", "url": "https://www.uniprot.org/uniprot/Q68FQ4", "type": "external" } ], "mass": 31058.0, "length": 267, "protein_name": "Cilia- and flagella-associated protein 300", "gene_name": "Cfap300", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 300", "refseq_ac": [ { "id": "NP_001034263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034263", "type": "external" } ], "gene_names_uniprotkb": "Cfap300", "gene_names_refseq": "Cfap300", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 300", "protein_names_refseq": "cilia- and flagella-associated protein 300; uncharacterized protein C11orf70 homolog", "tax_id": 10116, "disease": "primary ciliary dyskinesia 38 (Disease Ontology:DOID:0111852)", "pathway": " (rno:654482)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FQ4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR2-1", "uniprot_id": [ { "id": "BIN2_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR2", "type": "external" } ], "mass": 55118.0, "length": 507, "protein_name": "Bridging integrator 2", "gene_name": "Bin2", "organism": "Rat", "refseq_name": "bridging integrator 2", "refseq_ac": [ { "id": "NP_001012223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012223", "type": "external" } ], "gene_names_uniprotkb": "Bin2", "gene_names_refseq": "Bin2", "protein_names_uniprotkb": "Bridging integrator 2", "protein_names_refseq": "bridging integrator 2", "tax_id": 10116, "disease": "", "pathway": " (rno:366988); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;23285027;29393594", "class_list": "", "function": "Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation (By similarity). Plays a role in podosome formation. Inhibits phagocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0002102 podosome;GO:0042995 cell projection", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0060326 cell chemotaxis;GO:0071800 podosome assembly;GO:0097320 plasma membrane tubulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FW2-1", "uniprot_id": [ { "id": "CDCA3_RAT", "url": "https://www.uniprot.org/uniprot/Q68FW2", "type": "external" } ], "mass": 29611.0, "length": 273, "protein_name": "Cell division cycle-associated protein 3", "gene_name": "Cdca3", "organism": "Rat", "refseq_name": "cell division cycle-associated protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001007649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007649", "type": "external" } ], "gene_names_uniprotkb": "Cdca3; Tome1", "gene_names_refseq": "Cdca3", "protein_names_uniprotkb": "Cell division cycle-associated protein 3; TOME-1; Trigger of mitotic entry protein 1", "protein_names_refseq": "TOME-1; cell division cycle-associated protein 3 isoform 1; cell division cycle-associated protein 3; trigger of mitotic entry protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297594)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT3-1", "uniprot_id": [ { "id": "AR13A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT3", "type": "external" } ], "mass": 45467.0, "length": 395, "protein_name": "ADP-ribosylation factor-like protein 13A", "gene_name": "Arl13a", "organism": "Rat", "refseq_name": "ADP-ribosylation factor-like protein 13A", "refseq_ac": [ { "id": "NP_001019537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019537", "type": "external" } ], "gene_names_uniprotkb": "Arl13a", "gene_names_refseq": "Arl13a", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 13A", "protein_names_refseq": "ADP ribosylation factor like GTPase 13A; ADP-ribosylation factor-like 13A; ADP-ribosylation factor-like protein 13A", "tax_id": 10116, "disease": "", "pathway": " (rno:501617)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031514 motile cilium;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane;GO:0005929 cilium", "go_biological_process": "GO:1905515 non-motile cilium assembly;GO:0097500 receptor localization to non-motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU0-1", "uniprot_id": [ { "id": "BPI_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU0", "type": "external" } ], "mass": 53752.0, "length": 482, "protein_name": "Bactericidal permeability-increasing protein", "gene_name": "Bpi", "organism": "Rat", "refseq_name": "bactericidal permeability-increasing protein precursor", "refseq_ac": [ { "id": "NP_001004079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004079", "type": "external" } ], "gene_names_uniprotkb": "Bpi", "gene_names_refseq": "Bpifd1; Bpi", "protein_names_uniprotkb": "Bactericidal permeability-increasing protein; BPI", "protein_names_refseq": "BPI fold containing family D, member 1; bactericidal permeability-increasing protein precursor", "tax_id": 10116, "disease": "severe acute respiratory syndrome (Disease Ontology:DOID:2945); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:296321); (R-RNO-166016); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15009116", "class_list": "", "function": "Bactericidal/permeability-increasing protein BPI could exist in the inner root sheath cells of human and rat hair follicles, and might play a role as a barrier against anaerobic bacteria., [RefSeq, PubMed]; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXU0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXW0-1", "uniprot_id": [ { "id": "BOREA_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXW0", "type": "external" } ], "mass": 32099.0, "length": 288, "protein_name": "Borealin", "gene_name": "Cdca8", "organism": "Rat", "refseq_name": "borealin", "refseq_ac": [ { "id": "NP_001020221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020221", "type": "external" } ], "gene_names_uniprotkb": "Cdca8", "gene_names_refseq": "Cdca8", "protein_names_uniprotkb": "Borealin; Cell division cycle-associated protein 8", "protein_names_refseq": "borealin; cell division cycle-associated protein 8", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:500545); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0051233 spindle midzone;GO:0015630 microtubule cytoskeleton;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0051301 cell division;GO:0007080 mitotic metaphase chromosome alignment;GO:0000070 mitotic sister chromatid segregation;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY13-1", "uniprot_id": [ { "id": "CCNA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY13", "type": "external" } ], "mass": 47695.0, "length": 421, "protein_name": "Cyclin-A1", "gene_name": "Ccna1", "organism": "Rat", "refseq_name": "cyclin-A1", "refseq_ac": [ { "id": "NP_001011949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011949", "type": "external" } ], "gene_names_uniprotkb": "Ccna1", "gene_names_refseq": "Ccna1", "protein_names_uniprotkb": "Cyclin-A1", "protein_names_refseq": "cyclin-A1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:295052); (R-RNO-1538133); (R-RNO-171319); (R-RNO-174184); (R-RNO-176408); (R-RNO-187577); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-5689880); (R-RNO-5693607); (R-RNO-6804116); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-68911); (R-RNO-68949); (R-RNO-69017); (R-RNO-69273); (R-RNO-69478); (R-RNO-69563); (R-RNO-69656); (R-RNO-75035)", "pathway_count": 21, "publication_count": 3, "publication_id_list": "18278459;21764057;22180637", "class_list": "", "function": "Analysis of expression of Cyclin D1, E, A and B1 in neurons of cerebral cortex and hippocampus, [RefSeq, PubMed]; Data show that cyclin A1 and cyclin B1 gene expression is controlled by E(2) at a concentration of 10(-9)uM only in stages IX-I of spermatogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells (By similarity)., [UniProtKB, UniProtKB]; Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0097123 cyclin A1-CDK2 complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AY13-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY16-1", "uniprot_id": [ { "id": "ACTL9_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY16", "type": "external" } ], "mass": 46102.0, "length": 411, "protein_name": "Actin-like protein 9", "gene_name": "Actl9", "organism": "Rat", "refseq_name": "actin-like protein 9", "refseq_ac": [ { "id": "NP_001013915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013915", "type": "external" } ], "gene_names_uniprotkb": "Actl9; Actl7c", "gene_names_refseq": "Actl9b; Actl9", "protein_names_uniprotkb": "Actin-like protein 9", "protein_names_refseq": "actin-like protein 9", "tax_id": 10116, "disease": "spermatogenic failure 53 (Disease Ontology:DOID:0112279)", "pathway": " (rno:292516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0061827 sperm head;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle;GO:0033011 perinuclear theca", "go_biological_process": "GO:0009566 fertilization;GO:0007338 single fertilization;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY16-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY33-1", "uniprot_id": [ { "id": "ACRBP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY33", "type": "external" } ], "mass": 61080.0, "length": 540, "protein_name": "Acrosin-binding protein", "gene_name": "Acrbp", "organism": "Rat", "refseq_name": "acrosin-binding protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001020220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020220", "type": "external" } ], "gene_names_uniprotkb": "Acrbp", "gene_names_refseq": "Acrbp", "protein_names_uniprotkb": "Acrosin-binding protein; Acrosin-binding protein, 32 kDa form, mature form; Acrosin-binding protein, 60 kDa form; Proacrosin-binding protein sp32", "protein_names_refseq": "acrosin-binding protein isoform 1 precursor; acrosin-binding protein, 60 kDa form; proacrosin binding protein; proacrosin-binding protein sp32", "tax_id": 10116, "disease": "", "pathway": " (rno:500316)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis. Partially also contributes to the assembly of acrosomal proteins to form an acrosomal granule., [UniProtKB, UniProtKB]; Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis. In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY33-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY43-1", "uniprot_id": [ { "id": "DC2L1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY43", "type": "external" } ], "mass": 39670.0, "length": 351, "protein_name": "Cytoplasmic dynein 2 light intermediate chain 1", "gene_name": "Dync2li1", "organism": "Rat", "refseq_name": "cytoplasmic dynein 2 light intermediate chain 1", "refseq_ac": [ { "id": "NP_001382012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382012", "type": "external" } ], "gene_names_uniprotkb": "Dync2li1; Lic3", "gene_names_refseq": "Dync2li1; RGD1310286", "protein_names_uniprotkb": "Cytoplasmic dynein 2 light intermediate chain 1", "protein_names_refseq": "cytoplasmic dynein 2 light intermediate chain 1", "tax_id": 10116, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592)", "pathway": " (rno:298767); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11907264;12432068", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles. Involved in the regulation of ciliary length., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0031514 motile cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0035735 intraciliary transport involved in cilium assembly;GO:1902017 regulation of cilium assembly;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY43-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY45-1", "uniprot_id": [ { "id": "CCER1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY45", "type": "external" } ], "mass": 45792.0, "length": 400, "protein_name": "Coiled-coil domain-containing glutamate-rich protein 1", "gene_name": "Ccer1", "organism": "Rat", "refseq_name": "coiled-coil domain-containing glutamate-rich protein 1", "refseq_ac": [ { "id": "NP_001020223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020223", "type": "external" } ], "gene_names_uniprotkb": "Ccer1", "gene_names_refseq": "Ccer1", "protein_names_uniprotkb": "Coiled-coil domain-containing glutamate-rich protein 1", "protein_names_refseq": "coiled-coil domain-containing glutamate-rich protein 1; uncharacterized protein C12orf12 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of histone epigenetic modifications and chromatin compaction into the sperm head, required for histone-to-protamine (HTP) transition. HTP is a key event in which somatic histones are first replaced by testis-specific histone variants, then transition proteins (TNPs) are incorporated into the spermatid nucleus, and finally protamines (PRMs) replace the TNPs to promote chromatin condensation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY52-1", "uniprot_id": [ { "id": "SACDR_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY52", "type": "external" } ], "mass": 23486.0, "length": 200, "protein_name": "Sperm acrosome developmental regulator", "gene_name": "Spacdr", "organism": "Rat", "refseq_name": "sperm acrosome developmental regulator", "refseq_ac": [ { "id": "NP_001258165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258165", "type": "external" } ], "gene_names_uniprotkb": "Spacdr", "gene_names_refseq": "C12H7orf61; Spacdr", "protein_names_uniprotkb": "Sperm acrosome developmental regulator", "protein_names_refseq": "Uncharacterized protein C7orf61 homolog; sperm acrosome developmental regulator", "tax_id": 10116, "disease": "", "pathway": " (rno:100362783)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play an important role in acrosome formation and nucleus shaping during spermiogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY55-1", "uniprot_id": [ { "id": "DCAKD_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY55", "type": "external" } ], "mass": 27352.0, "length": 240, "protein_name": "Dephospho-CoA kinase domain-containing protein", "gene_name": "Dcakd", "organism": "Rat", "refseq_name": "dephospho-CoA kinase domain-containing protein", "refseq_ac": [ { "id": "NP_001007725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007725", "type": "external" } ], "gene_names_uniprotkb": "Dcakd", "gene_names_refseq": "Dcakd", "protein_names_uniprotkb": "Dephospho-CoA kinase domain-containing protein", "protein_names_refseq": "dephospho-CoA kinase domain-containing protein", "tax_id": 10116, "disease": "neurodegeneration with brain iron accumulation 6 (Disease Ontology:DOID:0110740)", "pathway": " (rno:360639); (R-RNO-196783)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY55-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY69-1", "uniprot_id": [ { "id": "ATGA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY69", "type": "external" } ], "mass": 25016.0, "length": 218, "protein_name": "Autophagy-related protein 101", "gene_name": "Atg101", "organism": "Rat", "refseq_name": "autophagy-related protein 101 isoform 1", "refseq_ac": [ { "id": "NP_001007660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007660", "type": "external" } ], "gene_names_uniprotkb": "Atg101", "gene_names_refseq": "Atg101; RGD1359310", "protein_names_uniprotkb": "Autophagy-related protein 101", "protein_names_refseq": "autophagy-related protein 101 isoform 1; autophagy-related protein 101", "tax_id": 10116, "disease": "colon cancer (Disease Ontology:DOID:219); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:300240); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010508 positive regulation of autophagy;GO:1903059 regulation of protein lipidation;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY69-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYC4-1", "uniprot_id": [ { "id": "CAPG_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYC4", "type": "external" } ], "mass": 38799.0, "length": 349, "protein_name": "Macrophage-capping protein", "gene_name": "Capg", "organism": "Rat", "refseq_name": "macrophage-capping protein", "refseq_ac": [ { "id": "NP_001013104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013104", "type": "external" } ], "gene_names_uniprotkb": "Capg", "gene_names_refseq": "Capg", "protein_names_uniprotkb": "Macrophage-capping protein; Actin regulatory protein CAP-G", "protein_names_refseq": "actin regulatory protein CAP-G; capping protein (actin filament), gelsolin-like; macrophage-capping protein", "tax_id": 10116, "disease": "", "pathway": " (rno:297339)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0071346 cellular response to type II interferon;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYE8-1", "uniprot_id": [ { "id": "ARTN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYE8", "type": "external" } ], "mass": 23656.0, "length": 224, "protein_name": "Artemin", "gene_name": "Artn", "organism": "Rat", "refseq_name": "artemin precursor", "refseq_ac": [ { "id": "NP_445849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445849", "type": "external" } ], "gene_names_uniprotkb": "Artn", "gene_names_refseq": "Artn", "protein_names_uniprotkb": "Artemin", "protein_names_refseq": "artemin precursor", "tax_id": 10116, "disease": "acoustic neuroma (Disease Ontology:DOID:12689); pancreatic cancer (Disease Ontology:DOID:1793); peripheral nervous system disease (Disease Ontology:DOID:574)", "pathway": " (rno:362572); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10719212;16325003;24886596;25889103;25918373;28899786;29712778;9883723", "class_list": "", "function": "ARTN acts as potent neurotrophic factor that may play an important role in the structural development and plasticity of ventral mesencephalic dopaminergic neurons, [RefSeq, PubMed]; Artemin has a role in robust regeneration of large, myelinated sensory axons to the brainstem and in promoting functional reinnervation of the cuneate nucleus, [RefSeq, PubMed]; Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Indicate the important roles of peripherally-derived artemin on the regulation of TRPV1/A1 in DRG neurons in pathological conditions such as inflammatory and neuropathic pain Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate a previously unknown role of artemin in regulating inducible form of nitric oxide synthase (iNOS) expression in primary cultured TGNs, and regulation of iNOS might be involved in the mechanism through which artemin participates in the trigeminal pain pathway., [RefSeq, PubMed]; This study suggest that Artn regulates the expression and composition of nAChRs in GFRalpha3 nociceptors and that these changes contribute to the thermal hypersensitivity that develops in response to Artn injection and perhaps to inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; We have shown evidence of a role for GDNF, neurturin, and artemin in the activation and sensitization of bone afferent neurons, and that sequestering these ligands reduces pain behavior in a model of inflammatory bone pain, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q810F6;Q810F7;Q9QZG3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0031175 neuron projection development;GO:0007422 peripheral nervous system development;GO:0007411 axon guidance;GO:0050930 induction of positive chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6AYE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK6-1", "uniprot_id": [ { "id": "CYBP_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK6", "type": "external" } ], "mass": 26541.0, "length": 229, "protein_name": "Calcyclin-binding protein", "gene_name": "Cacybp", "organism": "Rat", "refseq_name": "calcyclin-binding protein", "refseq_ac": [ { "id": "NP_001004208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004208", "type": "external" } ], "gene_names_uniprotkb": "Cacybp", "gene_names_refseq": "Cacybp", "protein_names_uniprotkb": "Calcyclin-binding protein; CacyBP", "protein_names_refseq": "calcyclin-binding protein", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:289144)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12042313;22926504;32544715;36042446;38203261;38780511", "class_list": "", "function": "CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases., [RefSeq, PubMed]; Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid receptors in the adrenals of hypertensive rats., [RefSeq, PubMed]; Evaluation of the Expression and Localization of the Multifunctional Protein CacyBP/SIP and Elements of the MAPK Signaling Pathway in the Adrenal Glands of Rats with Primary and Secondary Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity)., [UniProtKB]; Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; The level of CacyBP/SIP increases during development of breast cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007507 heart development;GO:0071277 cellular response to calcium ion;GO:1990830 cellular response to leukemia inhibitory factor;GO:0055007 cardiac muscle cell differentiation;GO:0060416 response to growth hormone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6AYK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYM9-1", "uniprot_id": [ { "id": "CLN8_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYM9", "type": "external" } ], "mass": 33120.0, "length": 288, "protein_name": "Protein CLN8", "gene_name": "Cln8", "organism": "Rat", "refseq_name": "protein CLN8", "refseq_ac": [ { "id": "NP_001007687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007687", "type": "external" } ], "gene_names_uniprotkb": "Cln8", "gene_names_refseq": "Cln8", "protein_names_uniprotkb": "Protein CLN8", "protein_names_refseq": "ceroid-lipofuscinosis, neuronal 8; protein CLN8", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 8 (Disease Ontology:DOID:0110723); neuronal ceroid lipofuscinosis 8 northern epilepsy variant (Disease Ontology:DOID:0110724)", "pathway": " (rno:306619)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Could play a role in cell proliferation during neuronal differentiation and in protection against cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097001 ceramide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0007399 nervous system development;GO:0008203 cholesterol metabolic process;GO:0008306 associative learning;GO:0008344 adult locomotory behavior;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYM9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYN9-1", "uniprot_id": [ { "id": "CC181_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYN9", "type": "external" } ], "mass": 59291.0, "length": 509, "protein_name": "Coiled-coil domain-containing protein 181", "gene_name": "Ccdc181", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 181", "refseq_ac": [ { "id": "NP_001014153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014153", "type": "external" } ], "gene_names_uniprotkb": "Ccdc181", "gene_names_refseq": "Ccdc181; RGD1309708", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 181", "protein_names_refseq": "coiled-coil domain-containing protein 181; uncharacterized protein C1orf114 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-binding protein that is essential for the integrity and function of the manchette, facilitating proper sperm head shaping and subsequent flagellum formation during spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0002177 manchette;GO:0005930 axoneme", "go_biological_process": "GO:0007286 spermatid development;GO:1905198 manchette assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYN9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYP7-1", "uniprot_id": [ { "id": "5NT3B_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYP7", "type": "external" } ], "mass": 34536.0, "length": 300, "protein_name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "gene_name": "Nt5c3b", "organism": "Rat", "refseq_name": "7-methylguanosine phosphate-specific 5'-nucleotidase", "refseq_ac": [ { "id": "NP_001007724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007724", "type": "external" } ], "gene_names_uniprotkb": "Nt5c3b; Nt5c3l", "gene_names_refseq": "Nt5c3b; Nt5c3l", "protein_names_uniprotkb": "7-methylguanosine phosphate-specific 5'-nucleotidase; 3.1.3.5; 3.1.3.91; 7-methylguanosine nucleotidase; Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein; N(7)-methylguanylate 5'-phosphatase; cN-III-like protein", "protein_names_refseq": "5'-nucleotidase, cytosolic III-like; 7-methylguanosine nucleotidase; 7-methylguanosine phosphate-specific 5'-nucleotidase; N(7)-methylguanylate 5'-phosphatase; cN-III-like protein; cytosolic 5'-nucleotidase 3B; cytosolic 5'-nucleotidase III-like protein; cytosolic 5-nucleotidase III-like protein-like", "tax_id": 10116, "disease": "", "pathway": " (rno:360629); (R-RNO-429958)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WG43", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0016787 hydrolase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYP7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYS7-1", "uniprot_id": [ { "id": "ACY1A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYS7", "type": "external" } ], "mass": 45804.0, "length": 408, "protein_name": "Aminoacylase-1A", "gene_name": "Acy1a; Acy1b; Acy1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Acy1a; Acy1b; Acy1; Acy1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aminoacylase-1A; 3.5.1.14; ACY IA; ACY-1A; N-acyl-L-amino-acid amidohydrolase; f-Met deformylase; fMDF", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300981); (R-RNO-5423646); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11012679;15253876;15938642;22673903", "class_list": "", "function": "Aminoacylase involved in the hydrolysis of N-acetylated and N-formylated amino acids. May act sequentially with APEH in the degradation of N-acylated peptides: APEH first cleaves N-acylaminoacids from N-acylated peptides, then ACY1 further hydrolyzes the N-acylaminoacid into free aminoacid and a carboxylate., [UniProtKB, PubMed]; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PTT1", "ec_number_list": [ { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" }, { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008463 formylmethionine deformylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AYS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGF9-1", "uniprot_id": [ { "id": "ACBD4_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGF9", "type": "external" } ], "mass": 37316.0, "length": 326, "protein_name": "Acyl-CoA-binding domain-containing protein 4", "gene_name": "Acbd4", "organism": "Rat", "refseq_name": "acyl-CoA-binding domain-containing protein 4 isoform 3", "refseq_ac": [ { "id": "NP_001012013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012013", "type": "external" } ], "gene_names_uniprotkb": "Acbd4", "gene_names_refseq": "Acbd4", "protein_names_uniprotkb": "Acyl-CoA-binding domain-containing protein 4", "protein_names_refseq": "acyl-CoA-binding domain-containing protein 4 isoform 3; acyl-CoA-binding domain-containing protein 4; acyl-Coenzyme A binding domain containing 4", "tax_id": 10116, "disease": "", "pathway": " (rno:303577); (R-RNO-390918)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DGF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IML7-1", "uniprot_id": [ { "id": "DJC27_RAT", "url": "https://www.uniprot.org/uniprot/Q6IML7", "type": "external" } ], "mass": 30949.0, "length": 273, "protein_name": "DnaJ homolog subfamily C member 27", "gene_name": "Dnajc27", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 27", "refseq_ac": [ { "id": "NP_996727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996727", "type": "external" } ], "gene_names_uniprotkb": "Dnajc27; Rbj", "gene_names_refseq": "Dnajc27; Rbj", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 27; Rab and DnaJ domain-containing protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 27; dnaJ homolog subfamily C member 27; rab and DnaJ domain containing; rab and DnaJ domain-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:298859)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14980719", "class_list": "", "function": "GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IML7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG60-1", "uniprot_id": [ { "id": "DDAH2_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG60", "type": "external" } ], "mass": 29688.0, "length": 285, "protein_name": "Putative hydrolase DDAH2", "gene_name": "Ddah2", "organism": "Rat", "refseq_name": "putative hydrolase DDAH2", "refseq_ac": [ { "id": "NP_001159408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159408", "type": "external" } ], "gene_names_uniprotkb": "Ddah2", "gene_names_refseq": "Ddah2", "protein_names_uniprotkb": "Putative hydrolase DDAH2; 3.-.-.-; DDAH-2; DDAHII; Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Inactive dimethylarginine dimethylaminohydrolase 2", "protein_names_refseq": "DDAH-2; DDAHII; dimethylargininase-2; inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; inactive dimethylarginine dimethylaminohydrolase 2; n(G),N(G)-dimethylarginine dimethylaminohydrolase 2; putative hydrolase DDAH2", "tax_id": 10116, "disease": "", "pathway": " (rno:294239)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15060004;17322279;17673667;18824664;23619555;23702602;26911182;27957828;29119338", "class_list": "", "function": "DDAH-2-ADMA/MMA-endothelial NO synthase regulatory pathway and NO-induced cGMP constitute a positive feedback loop that ultimately serves to maintain NO levels in the endothelial environment, [RefSeq, PubMed]; Endothelium-derived relaxing factor is metabolized by DDAH-2, which is strongly expressed in blood vessels., [RefSeq, PubMed]; Findings suggested that in the development of type 2 diabetes mellitus, local DDAH-2 in adipocytes might play an important role in regulating insulin sensitivity, [RefSeq, PubMed]; Higher levels of asymmetric dimethylarginine are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rat model., [RefSeq, PubMed]; Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway., [RefSeq, PubMed]; Putative hydrolase with unknown substrate. Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (By similarity). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Suppression of DDAH2 expression might account for, at least partially, the vascular endothelial dysfunction in hyperlipidemia, and nmMLC20 plays a role in suppression of DDAH2 expression in a phosphorylation-dependent manner., [RefSeq, PubMed]; The DDAH activity and DDAH1, but not DDAH2, protein expression were significantly reduced in pulmonary artery endothelial cells of rats given monocrotaline, [RefSeq, PubMed]; The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6MG60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG61-1", "uniprot_id": [ { "id": "CLIC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG61", "type": "external" } ], "mass": 26981.0, "length": 241, "protein_name": "Chloride intracellular channel protein 1", "gene_name": "Clic1", "organism": "Rat", "refseq_name": "chloride intracellular channel protein 1", "refseq_ac": [ { "id": "NP_001002807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002807", "type": "external" } ], "gene_names_uniprotkb": "Clic1", "gene_names_refseq": "Clic1", "protein_names_uniprotkb": "Chloride intracellular channel protein 1; 1.8.-.-; 1.8.5.1; Glutaredoxin-like oxidoreductase CLIC1; Glutathione-dependent dehydroascorbate reductase CLIC1", "protein_names_refseq": "chloride intracellular channel 1; chloride intracellular channel protein 1; glutaredoxin-like oxidoreductase CLIC1; glutathione-dependent dehydroascorbate reductase CLIC1", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:406864)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15060004;15190104;18047804;22673903;23743620;26777142", "class_list": "", "function": "Examined the effect of pharmacological blockade of CLIC1 in protecting cortical neurons from toxicity caused by Abeta1-42- and lipopolysaccaride-stimulated microglia, [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The authors report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria., [RefSeq, PubMed]; These results provide a direct link between Abeta-induced microglial activation and CLIC1 functional expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051881 regulation of mitochondrial membrane potential;GO:0006821 chloride transport;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6MG61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P720-1", "uniprot_id": [ { "id": "ARHGP_RAT", "url": "https://www.uniprot.org/uniprot/Q6P720", "type": "external" } ], "mass": 64160.0, "length": 579, "protein_name": "Rho guanine nucleotide exchange factor 25", "gene_name": "Arhgef25", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arhgef25; Geft", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 25; Guanine nucleotide exchange factor GEFT; Rac/Cdc42/Rho exchange factor GEFT; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT", "protein_names_refseq": "", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:314904); (R-RNO-193648); (R-RNO-416476); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030017 sarcomere;GO:0030016 myofibril;GO:0019898 extrinsic component of membrane", "go_biological_process": "GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P720-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7P5-1", "uniprot_id": [ { "id": "5MP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7P5", "type": "external" } ], "mass": 48043.0, "length": 419, "protein_name": "eIF5-mimic protein 2", "gene_name": "Bzw1", "organism": "Rat", "refseq_name": "eIF5-mimic protein 2", "refseq_ac": [ { "id": "NP_942084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942084", "type": "external" } ], "gene_names_uniprotkb": "Bzw1; 5mp2", "gene_names_refseq": "Bzw1", "protein_names_uniprotkb": "eIF5-mimic protein 2; Basic leucine zipper and W2 domain-containing protein 1", "protein_names_refseq": "basic leucine zipper and W2 domain-containing protein 1; eIF5-mimic protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363232)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity). Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7P5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCT8-1", "uniprot_id": [ { "id": "DHSD_RAT", "url": "https://www.uniprot.org/uniprot/Q6PCT8", "type": "external" } ], "mass": 16976.0, "length": 159, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "Sdhd", "organism": "Rat", "refseq_name": "succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "refseq_ac": [ { "id": "NP_942083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942083", "type": "external" } ], "gene_names_uniprotkb": "Sdhd", "gene_names_refseq": "CII-4; QPs3; Sdhd; cybS", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CII-4; CybS; Malate dehydrogenase [quinone] cytochrome b small subunit; QPs3; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit", "protein_names_refseq": "malate dehydrogenase [quinone] cytochrome b small subunit; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit", "tax_id": 10116, "disease": "paraganglioma (Disease Ontology:DOID:0050773); mitochondrial complex II deficiency (Disease Ontology:DOID:0060537); pheochromocytoma/paraganglioma syndrome 1 (Disease Ontology:DOID:0061216); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:363061); (R-RNO-71403); (R-RNO-9854311)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "26225774;31774353", "class_list": "", "function": "Aging reduces succinate dehydrogenase activity in rat type IIx/IIb diaphragm muscle fibers., [RefSeq, PubMed]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Metabolic sensors via Sirt3 maximize the cellular reserve respiratory capacity through activating mitochondrial complex II, which enhances cell survival after hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0043495 protein-membrane adaptor activity;GO:0008177 succinate dehydrogenase (quinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0071456 cellular response to hypoxia;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0006121 mitochondrial electron transport, succinate to ubiquinone;GO:0050433 regulation of catecholamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6PCT8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDU5-1", "uniprot_id": [ { "id": "BEX3_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDU5", "type": "external" } ], "mass": 15333.0, "length": 130, "protein_name": "Protein BEX3", "gene_name": "Bex3", "organism": "Rat", "refseq_name": "protein BEX3 isoform 1", "refseq_ac": [ { "id": "NP_445853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445853", "type": "external" } ], "gene_names_uniprotkb": "Bex3; Nade; Ngfrap1", "gene_names_refseq": "Bex3; Nade; Ngfrap1", "protein_names_uniprotkb": "Protein BEX3; Brain-expressed X-linked protein 3 homolog; Nerve growth factor receptor-associated protein 1; p75NTR-associated cell death executor; rBex3", "protein_names_refseq": "brain-expressed X-linked protein 3 homolog; nerve growth factor receptor (TNFRSF16) associated protein 1; nerve growth factor receptor-associated protein 1; p75NTR-associated cell death executor; protein BEX3 isoform 1; protein BEX3; rBex3", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); mitochondrial DNA depletion syndrome 1 (Disease Ontology:DOID:0080119); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); teratoma (Disease Ontology:DOID:3307); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); common bile duct neoplasm (Disease Ontology:DOID:4608); gallbladder carcinoma (Disease Ontology:DOID:4948); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:117089); (R-RNO-205025)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10764727;11124986;11224788;12377384;12873743;15958283;17355907;19141972;24616056;25948268", "class_list": "", "function": "Bex3 has an important role for the regulation of TrkA expression in neurons., [RefSeq, PubMed]; Expression of p75NTR increased in glia, but was downregulated in sensory neurons in sciatic nerve injury and spinal cord injury., [RefSeq, PubMed]; Expression of p75NTR on cholinergic interneurons of the rat striatum is associated with delayed neuronal degeneration., [RefSeq, PubMed]; Hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in tuberous sclerosis complex, [RefSeq, PubMed]; May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF (PubMed:11124986). Plays a role in zinc-triggered neuronal death (PubMed:11124986). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity)., [UniProtKB, PubMed, UniProtKB]; Reducing neuronal p75NTR expression plays a critical role in switching satellite glial cells to a reactive state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIT2", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005163 nerve growth factor receptor binding;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0031397 negative regulation of protein ubiquitination;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6PDU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDU7-1", "uniprot_id": [ { "id": "ATP5L_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDU7", "type": "external" } ], "mass": 11433.0, "length": 103, "protein_name": "ATP synthase F(0) complex subunit g, mitochondrial", "gene_name": "Atp5mg", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit g, mitochondrial", "refseq_ac": [ { "id": "NP_997681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997681", "type": "external" } ], "gene_names_uniprotkb": "Atp5mg; Atp5l", "gene_names_refseq": "Atp5l; Atp5mg", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase membrane subunit g; ATPase subunit g", "protein_names_refseq": "ATP synthase F(0) complex subunit g, mitochondrial; ATP synthase subunit g, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G; ATPase subunit g", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:300677); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17575325;26446791;27213235;29393594", "class_list": "", "function": "Subunit g, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "G3V9A9", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6PDU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEB9-1", "uniprot_id": [ { "id": "CC127_RAT", "url": "https://www.uniprot.org/uniprot/Q6PEB9", "type": "external" } ], "mass": 30686.0, "length": 262, "protein_name": "Coiled-coil domain-containing protein 127", "gene_name": "Ccdc127", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 127", "refseq_ac": [ { "id": "NP_942061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942061", "type": "external" } ], "gene_names_uniprotkb": "Ccdc127", "gene_names_refseq": "Ccdc127; RGD735106", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 127", "protein_names_refseq": "coiled-coil domain-containing protein 127", "tax_id": 10116, "disease": "", "pathway": " (rno:308060)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates lipid droplet homeostasis. May be involved in the adipocyte differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6A8F9;A6JUU4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PEB9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEC4-1", "uniprot_id": [ { "id": "SKP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6PEC4", "type": "external" } ], "mass": 18672.0, "length": 163, "protein_name": "S-phase kinase-associated protein 1", "gene_name": "Skp1", "organism": "Rat", "refseq_name": "S-phase kinase-associated protein 1", "refseq_ac": [ { "id": "NP_001007609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007609", "type": "external" } ], "gene_names_uniprotkb": "Skp1; Skp1a", "gene_names_refseq": "Skp1a; Skp1", "protein_names_uniprotkb": "S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; S-phase kinase-associated protein 1A; p19A; p19skp1", "protein_names_refseq": "RNA polymerase II elongation factor-like protein OCP2; S-phase kinase-associated protein 1A; S-phase kinase-associated protein 1; cyclin A/CDK2-associated p19; cyclin-A/CDK2-associated protein p19; organ of Corti protein 2; p19A; p19skp1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:287280); (R-RNO-1169091); (R-RNO-1170546); (R-RNO-174113); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2565942); (R-RNO-2871837); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-68949); (R-RNO-69231); (R-RNO-69601); (R-RNO-8854050); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-917937); (R-RNO-9762114); (R-RNO-983168); (R-RNO-9929356)", "pathway_count": 25, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0008013 beta-catenin binding;GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:1990444 F-box domain binding", "go_cellular_component": "GO:0031467 Cul7-RING ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PEC4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QD51-1", "uniprot_id": [ { "id": "CCD80_RAT", "url": "https://www.uniprot.org/uniprot/Q6QD51", "type": "external" } ], "mass": 107691.0, "length": 949, "protein_name": "Coiled-coil domain-containing protein 80", "gene_name": "Ccdc80", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 80 precursor", "refseq_ac": [ { "id": "NP_071988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071988", "type": "external" } ], "gene_names_uniprotkb": "Ccdc80; Dro1; Ssg1", "gene_names_refseq": "CL2; Ccdc80; Dro1; Ssg1", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 80; Down-regulated by oncogenes 1 protein; SSG-1; Steroid-sensitive gene 1 protein", "protein_names_refseq": "SSG-1; coiled-coil domain-containing protein 80 precursor; coiled-coil domain-containing protein 80; down-regulated by oncogenes 1 protein; steroid sensitive gene 1; steroid-sensitive gene 1 protein", "tax_id": 10116, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:64387)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11356689;15563452;23449887;26479776", "class_list": "", "function": "Ccdc80 preferentially binds activated, tyrosyl-phosphorylated JAK2 but not kinase-inactive JAK2., [RefSeq, PubMed]; DRO1 may have a role in the development of colorectal and pancreatic cancers, [RefSeq, PubMed]; Promotes cell adhesion and matrix assembly., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRG8;Q9JKW4", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0001968 fibronectin binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0009617 response to bacterium;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6QD51-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TMA8-1", "uniprot_id": [ { "id": "ANGL4_RAT", "url": "https://www.uniprot.org/uniprot/Q6TMA8", "type": "external" } ], "mass": 44951.0, "length": 405, "protein_name": "Angiopoietin-related protein 4", "gene_name": "Angptl4", "organism": "Rat", "refseq_name": "angiopoietin-related protein 4 precursor", "refseq_ac": [ { "id": "NP_954546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954546", "type": "external" } ], "gene_names_uniprotkb": "Angptl4", "gene_names_refseq": "Angptl4", "protein_names_uniprotkb": "Angiopoietin-related protein 4; Angiopoietin-like protein 4; HFARP; Hepatic fibrinogen/angiopoietin-related protein", "protein_names_refseq": "HFARP; angiopoietin-like protein 4; angiopoietin-related protein 4 precursor; angiopoietin-related protein 4; hepatic fibrinogen/angiopoietin-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362850); (R-RNO-8963889); (R-RNO-9762292)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "14570927;31494661;31981598;32686149;36409042;36537603", "class_list": "", "function": "ANGPTL4 partially modulates STAT3 and could serve as an effective diabetic retinopathy treatment strategy. Publication Status: Online-Only, [RefSeq, PubMed]; Calcineurin inhibitors ameliorate PAN-induced podocyte injury through the NFAT-Angptl4 pathway., [RefSeq, PubMed]; Dysregulation of Angiopoietin-like-4 Associated with Hyperlipidemia-induced Renal Injury by AMPK/ACC Pathway., [RefSeq, PubMed]; Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via beta1 Integrin/FAK signaling in diabetic nephropathy., [RefSeq, PubMed]; Increased expression of angiopoietin-like protein 4 regulates matrix metalloproteinase-13 expression in Porphyromonas gingivalis lipopolysaccharides-stimulated gingival fibroblasts and ligature-induced experimental periodontitis., [RefSeq, PubMed]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042802 identical protein binding;GO:0055102 lipase inhibitor activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043335 protein unfolding;GO:0001525 angiogenesis;GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6TMA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UPE0-1", "uniprot_id": [ { "id": "CHDH_RAT", "url": "https://www.uniprot.org/uniprot/Q6UPE0", "type": "external" } ], "mass": 66389.0, "length": 599, "protein_name": "Choline dehydrogenase, mitochondrial", "gene_name": "Chdh", "organism": "Rat", "refseq_name": "choline dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_942026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942026", "type": "external" } ], "gene_names_uniprotkb": "Chdh", "gene_names_refseq": "CDH; CHD; Chdh", "protein_names_uniprotkb": "Choline dehydrogenase, mitochondrial; 1.1.99.1; CDH; CHD", "protein_names_refseq": "choline dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:290551); (R-RNO-6798163)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12951056;16920841", "class_list": "", "function": "Catalyzes the dehydrogenation of choline to betaine aldehyde in the mitochondria (PubMed:12951056). Involved in mitochondrial autophagy after mitochondrial damage (By similarity)., [UniProtKB, UniProtKB, PubMed]; Kidney betaine-homocysteine methyltransferase (BHMT) and liver Choline dehydrogenase (CHDH) expression were refractory to dietary choline and methionine, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.1", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008812 choline dehydrogenase activity;GO:0016614 oxidoreductase activity, acting on CH-OH group of donors", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019285 glycine betaine biosynthetic process from choline", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6UPE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XQG8-1", "uniprot_id": [ { "id": "CHST7_RAT", "url": "https://www.uniprot.org/uniprot/Q6XQG8", "type": "external" } ], "mass": 55091.0, "length": 485, "protein_name": "Carbohydrate sulfotransferase 7", "gene_name": "Chst7", "organism": "Rat", "refseq_name": "carbohydrate sulfotransferase 7 precursor", "refseq_ac": [ { "id": "NP_997483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997483", "type": "external" } ], "gene_names_uniprotkb": "Chst7", "gene_names_refseq": "Chst7; Gn6st-4", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 7; 2.8.2.-; 2.8.2.17; C6ST-2; Chondroitin 6-sulfotransferase 2; GST-5; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; GlcNAc6ST-4; Gn6st-4; N-acetylglucosamine 6-O-sulfotransferase 4", "protein_names_refseq": "C6ST-2; GST-5; N-acetylglucosamine 6-O-sulfotransferase 1; N-acetylglucosamine 6-O-sulfotransferase 4; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7; carbohydrate sulfotransferase 7 precursor; chondroitin 6-sulfotransferase 2; chondroitin 6-sulfotransferase 7; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; glcNAc6ST-4", "tax_id": 10116, "disease": "", "pathway": " (rno:302302); (R-RNO-2022870)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2TA65", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.17", "type": "external" }, { "id": "2.8.2.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.21", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008459 chondroitin 6-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6XQG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71S46-1", "uniprot_id": [ { "id": "AT5G3_RAT", "url": "https://www.uniprot.org/uniprot/Q71S46", "type": "external" } ], "mass": 14693.0, "length": 142, "protein_name": "ATP synthase F(0) complex subunit C3, mitochondrial", "gene_name": "Atp5mc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp5mc3; Atp5g3", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C3, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 3; ATP synthase proteolipid P3; ATPase protein 9; ATPase subunit c", "protein_names_refseq": "", "tax_id": 10116, "disease": "early-onset dystonia and/or spastic paraplegia (Disease Ontology:DOID:0070445); mitochondrial complex V (ATP synthase) deficiency (Disease Ontology:DOID:0111143)", "pathway": " (R-RNO-1268020); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11459924;30530489", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity;GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0045471 response to ethanol;GO:0035994 response to muscle stretch;GO:0046931 pore complex assembly;GO:0015986 proton motive force-driven ATP synthesis;GO:0061959 response to (R)-carnitine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q71S46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76K24-1", "uniprot_id": [ { "id": "ANR46_RAT", "url": "https://www.uniprot.org/uniprot/Q76K24", "type": "external" } ], "mass": 25181.0, "length": 228, "protein_name": "Ankyrin repeat domain-containing protein 46", "gene_name": "Ankrd46", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 46", "refseq_ac": [ { "id": "NP_001013970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013970", "type": "external" } ], "gene_names_uniprotkb": "Ankrd46", "gene_names_refseq": "Ankrd46; RGD1309382; ank-s", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 46; ANK-S; Ankyrin repeat small protein", "protein_names_refseq": "ankyrin repeat domain-containing protein 46; ankyrin repeat small protein", "tax_id": 10116, "disease": "", "pathway": " (rno:299982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VGK7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76K24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78E60-1", "uniprot_id": [ { "id": "ARNT2_RAT", "url": "https://www.uniprot.org/uniprot/Q78E60", "type": "external" } ], "mass": 77958.0, "length": 712, "protein_name": "Aryl hydrocarbon receptor nuclear translocator 2", "gene_name": "Arnt2", "organism": "Rat", "refseq_name": "aryl hydrocarbon receptor nuclear translocator 2", "refseq_ac": [ { "id": "NP_036913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036913", "type": "external" } ], "gene_names_uniprotkb": "Arnt2", "gene_names_refseq": "Arnt2", "protein_names_uniprotkb": "Aryl hydrocarbon receptor nuclear translocator 2; ARNT protein 2", "protein_names_refseq": "ARNT protein 2; aryl hydrocarbon receptor nuclear translocator 2", "tax_id": 10116, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:25243); (R-RNO-211945); (R-RNO-211976); (R-RNO-211981); (R-RNO-8937144); (R-RNO-9768919)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "12684048;23861074", "class_list": "", "function": "Relative hippocampal NPAS4 expression was significantly lower in depression model rats compared to controls but there was no significant difference in hippocampal ARNT2 expression between groups, [RefSeq, PubMed]; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q30B64;Q63643;Q63646;Q80T24", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0017162 aryl hydrocarbon receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q78E60-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78EA7-1", "uniprot_id": [ { "id": "BMR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q78EA7", "type": "external" } ], "mass": 59994.0, "length": 532, "protein_name": "Bone morphogenetic protein receptor type-1A", "gene_name": "Bmpr1a", "organism": "Rat", "refseq_name": "bone morphogenetic protein receptor type-1A precursor", "refseq_ac": [ { "id": "NP_110476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110476", "type": "external" } ], "gene_names_uniprotkb": "Bmpr1a", "gene_names_refseq": "Bmpr1a", "protein_names_uniprotkb": "Bone morphogenetic protein receptor type-1A; 2.7.11.30; ALK-3; Activin receptor-like kinase 3; BMP type-1A receptor; BMPR-1A; Bone morphogenetic protein 4 receptor", "protein_names_refseq": "ALK-3; BMP type-1A receptor; BMPR-1A; activin receptor-like kinase 3; bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type-1A precursor; bone morphogenetic protein receptor, type IA", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); chromosome 10q23 deletion syndrome (Disease Ontology:DOID:0060389); hereditary mixed polyposis syndrome 2 (Disease Ontology:DOID:0111686); Ebstein anomaly (Disease Ontology:DOID:14289); hamartoma (Disease Ontology:DOID:3462); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); intestinal disease (Disease Ontology:DOID:5295); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:81507); (R-RNO-201451)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "27477499;30656682;7897267;7945360", "class_list": "", "function": "Downregulation of Bmpr1a and Bmp2 at the time of cloacal separation into the primitive rectum and UGS might be related to the development of anorectal malformations., [RefSeq, PubMed]; It is worthy to note that Aloin has the highest affinity to BMPR1A, whereas there are no reports regarding the impact of Aloenin, Aloesin, and gamma-sitosterol on osteogenesis., [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64308", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043235 receptor complex", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006955 immune response;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q78EA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78EJ9-1", "uniprot_id": [ { "id": "CAN8_RAT", "url": "https://www.uniprot.org/uniprot/Q78EJ9", "type": "external" } ], "mass": 79555.0, "length": 703, "protein_name": "Calpain-8", "gene_name": "Capn8", "organism": "Rat", "refseq_name": "calpain-8", "refseq_ac": [ { "id": "NP_579843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579843", "type": "external" } ], "gene_names_uniprotkb": "Capn8; Cls4; Ncl2", "gene_names_refseq": "CL-2'; Capn8; Cls4; nCL-2", "protein_names_uniprotkb": "Calpain-8; 3.4.22.53; Calpain large subunit 4; New calpain 2; Stomach-specific M-type calpain; nCL-2", "protein_names_refseq": "calpain large subunit 4; calpain-8; cysteine protease; new calpain 2; novel Calpain Large subunit; stomach-specific M-type calpain; tissue-specific calpain 2", "tax_id": 10116, "disease": "hereditary spastic paraplegia 76 (Disease Ontology:DOID:0110821); intellectual disability (Disease Ontology:DOID:1059); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hereditary spastic paraplegia (Disease Ontology:DOID:2476); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:170808); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12150941;16476741;7690035", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity)., [UniProtKB]; NCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64698;Q78EJ8;Q8K407", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:1990092 calcium-dependent self proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q78EJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TN78-1", "uniprot_id": [ { "id": "ACSM4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TN78", "type": "external" } ], "mass": 65317.0, "length": 580, "protein_name": "Acyl-coenzyme A synthetase ACSM4, mitochondrial", "gene_name": "Acsm4", "organism": "Rat", "refseq_name": "acyl-coenzyme A synthetase ACSM4, mitochondrial precursor", "refseq_ac": [ { "id": "NP_859046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859046", "type": "external" } ], "gene_names_uniprotkb": "Acsm4; Omacs", "gene_names_refseq": "Acsm4; Omacs", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM4, mitochondrial; 6.2.1.2; O-MACS; Olfactory specific medium-chain acyl CoA synthetase", "protein_names_refseq": "O-MACS; acyl-coenzyme A synthetase ACSM4, mitochondrial precursor; acyl-coenzyme A synthetase ACSM4, mitochondrial; olfactory specific medium-chain acyl CoA synthetase", "tax_id": 10116, "disease": "", "pathway": " (rno:353317); (R-RNO-177128); (R-RNO-9749641)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12709059", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:12709059). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (PubMed:12709059)., [UniProtKB, PubMed]; Results indicate that olfactory medium-chain acyl-CoA synthetase (O-MACS) may play an important role in processing odorants in a zone-specific manner, or in zonal patterning of the olfactory epithelium during development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0102391 decanoate-CoA ligase activity;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TN78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TS56-1", "uniprot_id": [ { "id": "CBR4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TS56", "type": "external" } ], "mass": 25287.0, "length": 236, "protein_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "gene_name": "Cbr4", "organism": "Rat", "refseq_name": "3-oxoacyl-[acyl-carrier-protein] reductase", "refseq_ac": [ { "id": "NP_872613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872613", "type": "external" } ], "gene_names_uniprotkb": "Cbr4", "gene_names_refseq": "Cbr4", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.100; 1.6.5.10; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; CBR4; Carbonyl reductase family member 4; KAR beta subunit; Quinone reductase CBR4", "protein_names_refseq": "3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; KAR beta subunit; carbonic reductase 4; carbonyl reductase family member 4; quinone reductase CBR4", "tax_id": 10116, "disease": "mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:359725); (R-RNO-75105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" } ], "go_molecular_function": "GO:0048038 quinone binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:1990204 oxidoreductase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006633 fatty acid biosynthetic process;GO:0051290 protein heterotetramerization;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TS56-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W57-1", "uniprot_id": [ { "id": "ABCG2_RAT", "url": "https://www.uniprot.org/uniprot/Q80W57", "type": "external" } ], "mass": 72961.0, "length": 657, "protein_name": "Broad substrate specificity ATP-binding cassette transporter ABCG2", "gene_name": "Abcg2", "organism": "Rat", "refseq_name": "broad substrate specificity ATP-binding cassette transporter ABCG2", "refseq_ac": [ { "id": "NP_852046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852046", "type": "external" } ], "gene_names_uniprotkb": "Abcg2; Bcrp1", "gene_names_refseq": "Abcg2; BCRP1; Bcrp", "protein_names_uniprotkb": "Broad substrate specificity ATP-binding cassette transporter ABCG2; 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein 1 homolog; Urate exporter", "protein_names_refseq": "ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; breast cancer resistance protein 1 homolog; broad substrate specificity ATP-binding cassette transporter ABCG2; urate exporter", "tax_id": 10116, "disease": "secondary hyperparathyroidism (Disease Ontology:DOID:12466); gout (Disease Ontology:DOID:13189); erythropoietic protoporphyria (Disease Ontology:DOID:13270); status epilepticus (Disease Ontology:DOID:1824); hyperuricemia (Disease Ontology:DOID:1920); breast carcinoma (Disease Ontology:DOID:3459); toxic encephalopathy (Disease Ontology:DOID:3602); renal cell carcinoma (Disease Ontology:DOID:4450); B-cell lymphoma (Disease Ontology:DOID:707); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:312382); (R-RNO-1660661); (R-RNO-189451); (R-RNO-189483); (R-RNO-917937); (R-RNO-9753281); (R-RNO-9793528)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "12819005;15255930;18451542;21454685;22673903;31983315;33558655;33790363;34255797;35345975", "class_list": "", "function": "ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat. Erratum:[Nucleosides Nucleotides Nucleic Acids. 2020;39(10-12):1474. doi: 10.1080/15257770.2020.1834331. PMID: 33231139], [RefSeq, PubMed]; Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins., [RefSeq, PubMed]; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells. Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the vitamins riboflavin and biotin into milk (By similarity). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain. It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats., [RefSeq, PubMed]; Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80ST1;Q80UR3;Q80XF3", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0001708 cell fate specification;GO:0071559 response to transforming growth factor beta;GO:0061026 cardiac muscle tissue regeneration;GO:0097305 response to alcohol;GO:0097168 mesenchymal stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q80W57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W83-1", "uniprot_id": [ { "id": "2A5B_RAT", "url": "https://www.uniprot.org/uniprot/Q80W83", "type": "external" } ], "mass": 57326.0, "length": 497, "protein_name": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "gene_name": "Ppp2r5b", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "refseq_ac": [ { "id": "NP_852044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852044", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r5b; LOC100909468; rCG_47223", "gene_names_refseq": "Ppp2r5b", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; PP2A B subunit isoform B'-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:309179); (R-RNO-141430); (R-RNO-141444); (R-RNO-195253); (R-RNO-196299); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-389356); (R-RNO-389513); (R-RNO-432142); (R-RNO-4641262); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-5675221); (R-RNO-6811558); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 17, "publication_count": 3, "publication_id_list": "14985449;16129692;23135275", "class_list": "", "function": "As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072542 protein phosphatase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010469 regulation of signaling receptor activity;GO:0031334 positive regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80W83-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFC4-1", "uniprot_id": [ { "id": "BGAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFC4", "type": "external" } ], "mass": 39079.0, "length": 334, "protein_name": "Histo-blood group ABO system transferase 2", "gene_name": "Abo2; Abo", "organism": "Rat", "refseq_name": "histo-blood group ABO system transferase 2", "refseq_ac": [ { "id": "NP_001153735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153735", "type": "external" } ], "gene_names_uniprotkb": "Abo2; Abo", "gene_names_refseq": "Abo2; Abo", "protein_names_uniprotkb": "Histo-blood group ABO system transferase 2; 2.4.1.37; 2.4.1.40; A transferase; B blood group galactosyltransferase; B transferase; Blood group A glycosyltransferase 2; Cis-AB transferase 2; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Histo-blood group A transferase; Histo-blood group B transferase; NAGAT 2; Putative blood group A transferase T2", "protein_names_refseq": "ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; NAGAT 2; a transferase; b blood group galactosyltransferase; b transferase; blood group A glycosyltransferase 2; cis-AB transferase 2; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase 2; histo-blood group B transferase; putative blood group A transferase T2; transferase B, alpha 1-3-galactosyltransferase)", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); hypertension (Disease Ontology:DOID:10763); leukemia (Disease Ontology:DOID:1240); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); echinococcosis (Disease Ontology:DOID:1496); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis (Disease Ontology:DOID:2237); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); gallbladder carcinoma (Disease Ontology:DOID:4948); pneumonia (Disease Ontology:DOID:552); hemolytic anemia (Disease Ontology:DOID:583); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:100301568); (rno:296504); (R-RNO-9033807)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12180981;12237302;12799344", "class_list": "glycogene;glycosyltransferase", "function": "Possesses strong B transferase activity and weak A transferase activity., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.37", "type": "external" }, { "id": "2.4.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.40", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0000166 nucleotide binding;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0003823 antigen binding;GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0005975 carbohydrate metabolic process;GO:0032526 response to retinoic acid;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8CFC4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ11-1", "uniprot_id": [ { "id": "AGRG2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJ11", "type": "external" } ], "mass": 110701.0, "length": 1013, "protein_name": "Adhesion G protein-coupled receptor G2", "gene_name": "Adgrg2", "organism": "Rat", "refseq_name": "adhesion G-protein coupled receptor G2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001257800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257800", "type": "external" } ], "gene_names_uniprotkb": "Adgrg2; Gpr64; Re6", "gene_names_refseq": "Adgrg2; Gpr64; He6; Re6", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor G2; G protein-coupled receptor 64; Rat epididymis-specific protein 6; Re6", "protein_names_refseq": "G-protein coupled receptor 64; adhesion G-protein coupled receptor G2 isoform 2 precursor; epididymis-specific protein 6; re6 receptor", "tax_id": 10116, "disease": "X-linked congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111863)", "pathway": " (rno:266735)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12420295", "class_list": "", "function": "Adhesion G protein-coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione. Involved in a signal transduction pathway controlling epididymal function and male fertility. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple with G(q) G proteins in vitro. May regulate fluid exchange within epididymis., [UniProtKB, UniProtKB]; Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione. Involved in a signal transduction pathway controlling epididymal function and male fertility. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple with G(q) G proteins in vitro. May regulate fluid exchange within epididymis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 21, "predicted_n_glycosites": 20, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "Q8CJ06;Q8CJ07", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007286 spermatid development;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CJ11-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1M7-1", "uniprot_id": [ { "id": "BRNP3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1M7", "type": "external" } ], "mass": 88497.0, "length": 766, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 3", "gene_name": "Brinp3", "organism": "Rat", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 3 precursor", "refseq_ac": [ { "id": "NP_775144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775144", "type": "external" } ], "gene_names_uniprotkb": "Brinp3; Fam5c", "gene_names_refseq": "Brinp3; Fam5c", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 3", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 3 precursor; BMP/retinoic acid-inducible neural-specific protein 3; bone morphogenetic protein/retinoic acid inducible neural-specific 3; family with sequence similarity 5, member C; protein FAM5C", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aggressive periodontitis (Disease Ontology:DOID:1474); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:286901)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15193423;17138656", "class_list": "", "function": "Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development (By similarity)., [UniProtKB]; Results describe BRINP1, 2, and 3 genes, which have distinct regulatory mechanisms of expression within the nervous system and which suppress the cell cycle progression in nonneuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0035640 exploration behavior;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K1M7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K418-1", "uniprot_id": [ { "id": "BRS3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K418", "type": "external" } ], "mass": 44204.0, "length": 399, "protein_name": "Bombesin receptor subtype-3", "gene_name": "Brs3", "organism": "Rat", "refseq_name": "bombesin receptor subtype-3 isoform 1", "refseq_ac": [ { "id": "NP_690058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690058", "type": "external" } ], "gene_names_uniprotkb": "Brs3", "gene_names_refseq": "Brs3", "protein_names_uniprotkb": "Bombesin receptor subtype-3; BRS-3", "protein_names_refseq": "BRS-3; bombesin receptor subtype-3 isoform 1; bombesin-like receptor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:260319); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12102638;15140764;15726424;22911445;29402494", "class_list": "", "function": "BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces., [RefSeq, PubMed]; Bombesin receptor subtype-3 (BRS-3) was detected in the rat adult and fetal kidney., [RefSeq, PubMed]; Brs3 is expressed by the enteric nervous system and by interstitial cells of Cajal in the gastrointestinal tract., [RefSeq, PubMed]; Results indicate that the sequence variation in the E3 loop is responsible for the species difference between rat and human BRS-3, and multiple residues in the E3 loop are involved in interactions with the agonist dY-bombesin, [RefSeq, PubMed]; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB]; This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the rat brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K418-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4F7-1", "uniprot_id": [ { "id": "DCPS_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4F7", "type": "external" } ], "mass": 38714.0, "length": 336, "protein_name": "m7GpppX diphosphatase", "gene_name": "Dcps", "organism": "Rat", "refseq_name": "m7GpppX diphosphatase", "refseq_ac": [ { "id": "NP_695214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695214", "type": "external" } ], "gene_names_uniprotkb": "Dcps; Dcs1; Hint5", "gene_names_refseq": "DCS-1; Dcps; Hint-5", "protein_names_uniprotkb": "m7GpppX diphosphatase; 3.6.1.59; DCS-1; Decapping scavenger enzyme; HINT-5; Hint-related 7meGMP-directed hydrolase; Histidine triad nucleotide-binding protein 5; Histidine triad protein member 5; Scavenger mRNA-decapping enzyme DcpS", "protein_names_refseq": "decapping scavenger enzyme; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; m7GpppX diphosphatase; mRNA decapping enzyme; scavenger mRNA-decapping enzyme DcpS", "tax_id": 10116, "disease": "", "pathway": " (rno:266605); (R-RNO-429958)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP. Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0045292 mRNA cis splicing, via spliceosome;GO:0110156 mRNA methylguanosine-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K4F7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4F8-1", "uniprot_id": [ { "id": "CCNF_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4F8", "type": "external" } ], "mass": 86790.0, "length": 780, "protein_name": "Cyclin-F", "gene_name": "Ccnf", "organism": "Rat", "refseq_name": "cyclin-F", "refseq_ac": [ { "id": "NP_001093944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093944", "type": "external" } ], "gene_names_uniprotkb": "Ccnf", "gene_names_refseq": "Ccnf", "protein_names_uniprotkb": "Cyclin-F", "protein_names_refseq": "cyclin-F", "tax_id": 10116, "disease": "", "pathway": " (rno:117524); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZCW7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051301 cell division;GO:0001890 placenta development;GO:0016567 protein ubiquitination;GO:0000082 G1/S transition of mitotic cell cycle;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K4F8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4H4-1", "uniprot_id": [ { "id": "APTX_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4H4", "type": "external" } ], "mass": 37720.0, "length": 329, "protein_name": "Aprataxin", "gene_name": "Aptx", "organism": "Rat", "refseq_name": "aprataxin isoform a", "refseq_ac": [ { "id": "NP_683687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683687", "type": "external" } ], "gene_names_uniprotkb": "Aptx", "gene_names_refseq": "Aptx", "protein_names_uniprotkb": "Aprataxin; 3.6.1.71; 3.6.1.72; FHA-HIT; Forkhead-associated domain histidine triad-like protein", "protein_names_refseq": "FHA-HIT; aprataxin isoform a; forkhead-associated domain histidine triad-like protein", "tax_id": 10116, "disease": "early-onset ataxia with oculomotor apraxia and hypoalbuminemia (Disease Ontology:DOID:0050754); olivopontocerebellar atrophy (Disease Ontology:DOID:14784)", "pathway": " (rno:259271)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.71", "type": "external" }, { "id": "3.6.1.72", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.72", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0051219 phosphoprotein binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0000012 single strand break repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K4H4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R1R5-1", "uniprot_id": [ { "id": "C99L2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R1R5", "type": "external" } ], "mass": 26074.0, "length": 246, "protein_name": "CD99 antigen-like protein 2", "gene_name": "Cd99l2", "organism": "Rat", "refseq_name": "CD99 antigen-like protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001396499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001396499", "type": "external" } ], "gene_names_uniprotkb": "Cd99l2; Mic2l1; Rhombex40", "gene_names_refseq": "Cd99l2; Mic2l1; vms-tm2", "protein_names_uniprotkb": "CD99 antigen-like protein 2; MIC2-like protein 1; Protein rhombex-40; Rhombencephalic expression protein 40 kDa", "protein_names_refseq": "CD99 antigen-like protein 2 isoform 1 precursor; CD99 antigen-like protein 2-like; CD99 antigen-like protein 2; Cd99 antigen-like 2; MIC2 like 1; MIC2-like protein 1; Rhombex-40; protein rhombex-40; rhombencephalic expression protein 40 kDa; single-pass transmembrane protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171485)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10834302;12706889;29393594", "class_list": "", "function": "Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JJL7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:2000391 positive regulation of neutrophil extravasation;GO:0050904 diapedesis;GO:2000409 positive regulation of T cell extravasation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R1R5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2E7-1", "uniprot_id": [ { "id": "Q8R2E7_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2E7", "type": "external" } ], "mass": 23124.0, "length": 208, "protein_name": "FAS-associated death domain protein", "gene_name": "Fadd", "organism": "Rat", "refseq_name": "FAS-associated death domain protein", "refseq_ac": [ { "id": "NP_690920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690920", "type": "external" } ], "gene_names_uniprotkb": "Fadd", "gene_names_refseq": "Fadd; Mort1", "protein_names_uniprotkb": "FAS-associated death domain protein; FAS-associating death domain-containing protein", "protein_names_refseq": "FAS-associated death domain protein; Fas (TNFRSF6)-associated via death domain; protein FADD", "tax_id": 10116, "disease": "brain glioma (Disease Ontology:DOID:0060108); immunodeficiency 90 (Disease Ontology:DOID:0061060); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prostatic hypertrophy (Disease Ontology:DOID:11132); leukemia (Disease Ontology:DOID:1240); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:266610); (R-RNO-140534); (R-RNO-2562578); (R-RNO-3371378); (R-RNO-5218900); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5675482); (R-RNO-69416); (R-RNO-75157); (R-RNO-75158)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "22673903;27561622;29393594;30138765", "class_list": "", "function": "Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling., [UniProtKB, UniProtKB, UniProtKB]; Study shows that hypothermic effects induced by acute 8-OH-DPAT are associated with better cognitive scores and lower FADD content in the hippocampus of rats at different ages. In addition acute, but not repeated, 8-OH-DPAT treatments further decrease hippocampal FADD protein in rats at different ages., [RefSeq, PubMed]; Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R2E7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD48-1", "uniprot_id": [ { "id": "DHRS9_RAT", "url": "https://www.uniprot.org/uniprot/Q8VD48", "type": "external" } ], "mass": 35214.0, "length": 319, "protein_name": "Dehydrogenase/reductase SDR family member 9", "gene_name": "Dhrs9", "organism": "Rat", "refseq_name": "dehydrogenase/reductase SDR family member 9 precursor", "refseq_ac": [ { "id": "NP_570832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570832", "type": "external" } ], "gene_names_uniprotkb": "Dhrs9; eRolDH", "gene_names_refseq": "Dhrs9; Rdhl", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 9; 1.1.1.105; 1.1.1.209; 1.1.1.53; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; Retinol dehydrogenase; Short-chain dehydrogenase/reductase retSDR8", "protein_names_refseq": "3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha-HSD; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9 precursor; retinol dehydrogenase homolog; short-chain dehydrogenase/reductase retSDR8", "tax_id": 10116, "disease": "", "pathway": " (rno:170635); (R-RNO-5365859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12390888", "class_list": "", "function": "3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:12390888). Can utilize both NADH and NADPH (By similarity)., [UniProtKB, PubMed, UniProtKB]; This novel short-chain alcohol dehydrogenase is an excellent candidate for the retinol dehydrogenase that catalyzes the first step in retinoic acid biosynthesis that occurs in uterine epithelial cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016491 oxidoreductase activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042573 retinoic acid metabolic process;GO:0002138 retinoic acid biosynthetic process;GO:0042904 9-cis-retinoic acid biosynthetic process;GO:0008209 androgen metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VD48-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VD50-1", "uniprot_id": [ { "id": "DDT4L_RAT", "url": "https://www.uniprot.org/uniprot/Q8VD50", "type": "external" } ], "mass": 21400.0, "length": 193, "protein_name": "DNA damage-inducible transcript 4-like protein", "gene_name": "Ddit4l", "organism": "Rat", "refseq_name": "DNA damage-inducible transcript 4-like protein", "refseq_ac": [ { "id": "NP_001376203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376203", "type": "external" } ], "gene_names_uniprotkb": "Ddit4l; Smhs1", "gene_names_refseq": "Ddit4l", "protein_names_uniprotkb": "DNA damage-inducible transcript 4-like protein; Soleus muscle atrophied after hindlimb suspension protein 1", "protein_names_refseq": "DNA damage-inducible transcript 4-like protein; DNA-damage-inducible transcript 4-like protein-like; soleus muscle atrophied after hindlimb suspension protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:100363484)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11596118", "class_list": "", "function": "Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VD50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW7-1", "uniprot_id": [ { "id": "CCG6_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHW7", "type": "external" } ], "mass": 28255.0, "length": 260, "protein_name": "Voltage-dependent calcium channel gamma-6 subunit", "gene_name": "Cacng6", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-6 subunit", "refseq_ac": [ { "id": "NP_542425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542425", "type": "external" } ], "gene_names_uniprotkb": "Cacng6", "gene_names_refseq": "Cacng6", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-6 subunit; Neuronal voltage-gated calcium channel gamma-6 subunit", "protein_names_refseq": "calcium channel, voltage-dependent, gamma subunit 6; neuronal voltage-gated calcium channel gamma-6 subunit; voltage-dependent calcium channel gamma-6 subunit", "tax_id": 10116, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822)", "pathway": " (rno:140727); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11738816;21127204", "class_list": "", "function": "Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHW6", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW8-1", "uniprot_id": [ { "id": "CCG5_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHW8", "type": "external" } ], "mass": 30924.0, "length": 275, "protein_name": "Voltage-dependent calcium channel gamma-5 subunit", "gene_name": "Cacng5", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-5 subunit", "refseq_ac": [ { "id": "NP_542424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542424", "type": "external" } ], "gene_names_uniprotkb": "Cacng5", "gene_names_refseq": "Cacng5", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; TARP gamma-5; Transmembrane AMPAR regulatory protein gamma-5", "protein_names_refseq": "TARP gamma-5; calcium channel, voltage-dependent, gamma subunit 5; neuronal voltage-gated calcium channel gamma-5 subunit; transmembrane AMPAR regulatory protein gamma-5; voltage-dependent calcium channel gamma-5 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:140726)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11738816;18817736;19234459;19265014", "class_list": "", "function": "Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. According to PubMed:18817736, shows only specificity for GRIA2 and specifically to the form of GRIA2 for which a single amino acid in the pore region has been edited from a glutamine to an arginine residue. Thought to stabilize the calcium channel in an inactivated (closed) state., [UniProtKB, PubMed, PubMed]; Whereas gamma-5 interacts with all AMPA-type glutamate receptor subunits, it predominantly regulates the functions of calcium-permeable AMPA receptor subunit combinations lacking short-form subunits in Bergmann glia. Erratum:[Nat Neurosci. 2009 Jun;12(6):808], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VHW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW9-1", "uniprot_id": [ { "id": "CCG4_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHW9", "type": "external" } ], "mass": 36523.0, "length": 327, "protein_name": "Voltage-dependent calcium channel gamma-4 subunit", "gene_name": "Cacng4", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-4 subunit", "refseq_ac": [ { "id": "NP_542423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542423", "type": "external" } ], "gene_names_uniprotkb": "Cacng4", "gene_names_refseq": "Cacng4", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-4 subunit; Neuronal voltage-gated calcium channel gamma-4 subunit; TARP gamma-4; Transmembrane AMPAR regulatory protein gamma-4", "protein_names_refseq": "TARP gamma-4; calcium channel, voltage-dependent, gamma subunit 4; neuronal voltage-gated calcium channel gamma-4 subunit; transmembrane AMPAR regulatory protein gamma-4; voltage-dependent calcium channel gamma-4 subunit", "tax_id": 10116, "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:140725); (R-RNO-112308); (R-RNO-399719); (R-RNO-5576892); (R-RNO-5576893); (R-RNO-5682910)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11738816;17670991;17880894;19234459;19265014;21127204;22673903", "class_list": "", "function": "Cacng4 (gamma-4) modulates the desensitization properties of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors significantly more strongly than can Cacng2 (gamma-2)., [RefSeq, PubMed]; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed:17880894, PubMed:19234459)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0032281 AMPA glutamate receptor complex;GO:0044297 cell body;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0042220 response to cocaine;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8VHW9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI04-1", "uniprot_id": [ { "id": "ASGL1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VI04", "type": "external" } ], "mass": 34410.0, "length": 333, "protein_name": "Isoaspartyl peptidase/L-asparaginase", "gene_name": "Asrgl1", "organism": "Rat", "refseq_name": "isoaspartyl peptidase/L-asparaginase", "refseq_ac": [ { "id": "NP_659557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659557", "type": "external" } ], "gene_names_uniprotkb": "Asrgl1; Alp; Gliap; Hiob", "gene_names_refseq": "Asrgl1; Gliap; Hiob2", "protein_names_uniprotkb": "Isoaspartyl peptidase/L-asparaginase; 3.4.19.5; 3.5.1.1; Asparaginase-like protein 1; Asparaginase-like sperm autoantigen; Beta-aspartyl-peptidase; Glial asparaginase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase", "protein_names_refseq": "ALP; L-asparaginase; L-asparagine amidohydrolase; asparaginase like 1; asparaginase-like protein 1; asparaginase-like sperm autoantigen; beta-aspartyl-peptidase; glial asparaginase; isoaspartyl dipeptidase; isoaspartyl peptidase/L-asparaginase", "tax_id": 10116, "disease": "", "pathway": " (rno:246307); (R-RNO-8964208)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11984834;12753071", "class_list": "", "function": "A novel asparaginase-like protein (ALP) of spermatozoa was cloned from rat and human testis cDNA libraries on the basis of reactivity with antibodies produced after vasectomy, [RefSeq, PubMed]; Gliap is abundant in liver and testis and in brain Gliap is exclusively expressed in astrocytes and present in structures resembling glial endfeet. This suggests Gliap is involved in astroglial production of the neuroactive amino acid L-aspartate, [RefSeq, PubMed]; Has both L-asparaginase and beta-aspartyl peptidase activity. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine (By similarity). May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CG44", "ec_number_list": [ { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.19.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.5", "type": "external" } ], "go_molecular_function": "GO:0004067 asparaginase activity;GO:0008798 beta-aspartyl-peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0006508 proteolysis;GO:0033345 L-asparagine catabolic process via L-aspartate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VI04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91VC0-1", "uniprot_id": [ { "id": "DCTP1_RAT", "url": "https://www.uniprot.org/uniprot/Q91VC0", "type": "external" } ], "mass": 18474.0, "length": 170, "protein_name": "dCTP pyrophosphatase 1", "gene_name": "Dctpp1", "organism": "Rat", "refseq_name": "dCTP pyrophosphatase 1", "refseq_ac": [ { "id": "NP_620247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620247", "type": "external" } ], "gene_names_uniprotkb": "Dctpp1", "gene_names_refseq": "Dctpp1; RS21-C6; Rs21c6; Xtp3tpa", "protein_names_uniprotkb": "dCTP pyrophosphatase 1; 3.6.1.12; Deoxycytidine-triphosphatase 1; RS21-C6; dCTPase 1", "protein_names_refseq": "XTP3-transactivated gene A protein homolog; XTP3-transactivated protein A; dCTP pyrophosphatase 1; dCTPase 1; deoxycytidine-triphosphatase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192252)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.12", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0032556 pyrimidine deoxyribonucleotide binding;GO:0047840 dCTP diphosphatase activity;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006253 dCTP catabolic process;GO:0042262 DNA protection;GO:0009143 nucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q91VC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZF7-1", "uniprot_id": [ { "id": "AARD_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZF7", "type": "external" } ], "mass": 18777.0, "length": 165, "protein_name": "Alanine- and arginine-rich domain-containing protein", "gene_name": "Aard", "organism": "Rat", "refseq_name": "alanine- and arginine-rich domain-containing protein", "refseq_ac": [ { "id": "NP_659561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659561", "type": "external" } ], "gene_names_uniprotkb": "Aard; A5d3", "gene_names_refseq": "A5D3; Aard", "protein_names_uniprotkb": "Alanine- and arginine-rich domain-containing protein; rA5D3", "protein_names_refseq": "alanine- and arginine-rich domain-containing protein; rA5D3", "tax_id": 10116, "disease": "", "pathway": " (rno:246323)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11997109", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0030324 lung development;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZN1-1", "uniprot_id": [ { "id": "COR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZN1", "type": "external" } ], "mass": 51065.0, "length": 461, "protein_name": "Coronin-1A", "gene_name": "Coro1a", "organism": "Rat", "refseq_name": "coronin-1A", "refseq_ac": [ { "id": "NP_569095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569095", "type": "external" } ], "gene_names_uniprotkb": "Coro1a; Coro1", "gene_names_refseq": "Coro1a", "protein_names_uniprotkb": "Coronin-1A; Clipin-A; Coronin-like protein A; TACO; Tryptophan aspartate-containing coat protein", "protein_names_refseq": "TACO; clipin-A; coronin, actin binding protein 1A; coronin-1A; coronin-like protein A; tryptophan aspartate-containing coat protein", "tax_id": 10116, "disease": "coronin-1A deficiency (Disease Ontology:DOID:0060019); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); severe combined immunodeficiency 104 (Disease Ontology:DOID:0090014)", "pathway": " (rno:155151)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18683930;22673903;25179994;26809475", "class_list": "", "function": "Coronin 1A has an inhibitory effect on neurite outgrowth in vitro., [RefSeq, PubMed]; Formation of filopodia by membrane glycoprotein M6a (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1., [RefSeq, PubMed]; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005884 actin filament", "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q91ZN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920F5-1", "uniprot_id": [ { "id": "DCMC_RAT", "url": "https://www.uniprot.org/uniprot/Q920F5", "type": "external" } ], "mass": 54762.0, "length": 492, "protein_name": "Malonyl-CoA decarboxylase, mitochondrial", "gene_name": "Mlycd", "organism": "Rat", "refseq_name": "malonyl-CoA decarboxylase, mitochondrial", "refseq_ac": [ { "id": "NP_445929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445929", "type": "external" } ], "gene_names_uniprotkb": "Mlycd", "gene_names_refseq": "Mcd; Mlycd", "protein_names_uniprotkb": "Malonyl-CoA decarboxylase, mitochondrial; 4.1.1.9; MCD", "protein_names_refseq": "malonyl-CoA decarboxylase, mitochondrial", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:85239); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10229677;10455107;10947976;12297032;15105298;16298369;16739991", "class_list": "", "function": "Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUY2", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050080 malonyl-CoA decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0002931 response to ischemia;GO:0007584 response to nutrient;GO:0006633 fatty acid biosynthetic process;GO:0010906 regulation of glucose metabolic process;GO:0046320 regulation of fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q920F5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JA2-1", "uniprot_id": [ { "id": "ASIP_RAT", "url": "https://www.uniprot.org/uniprot/Q99JA2", "type": "external" } ], "mass": 14276.0, "length": 131, "protein_name": "Agouti-signaling protein", "gene_name": "Asip", "organism": "Rat", "refseq_name": "agouti-signaling protein precursor", "refseq_ac": [ { "id": "NP_443211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443211", "type": "external" } ], "gene_names_uniprotkb": "Asip; A", "gene_names_refseq": "ASP; Asip", "protein_names_uniprotkb": "Agouti-signaling protein; ASP; Agouti switch protein", "protein_names_refseq": "Agouti (coat color); agouti switch protein; agouti-signaling protein precursor", "tax_id": 10116, "disease": "pigmentation disease (Disease Ontology:DOID:10123); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11353396;19534427;29219041", "class_list": "", "function": "Aggressive offspring is more sensitive to the mother's methyl-containing diet: the percentage of animals that are darker than control rats is higher among aggressive animals than among tame ones, [RefSeq, PubMed]; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment)., [UniProtKB, PubMed]; These results suggest a possible in-situ mutation of the Asip gene, either within the RrC lineage II population on Okinawa or in an unsampled RrC lineage II population with biogeographic links to Okinawa, although incomplete lineage sorting could not be ruled out., [RefSeq, PubMed]; This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0005184 neuropeptide hormone activity;GO:0070996 type 1 melanocortin receptor binding;GO:0031779 melanocortin receptor binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0009755 hormone-mediated signaling pathway;GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99JA2-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPH1-1", "uniprot_id": [ { "id": "A1BG_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPH1", "type": "external" } ], "mass": 56479.0, "length": 513, "protein_name": "Alpha-1B-glycoprotein", "gene_name": "A1bg", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "A1bg", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1B-glycoprotein; Alpha-1-B glycoprotein; C44; Liver regeneration-related protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:140656); (R-RNO-114608); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11097837;11356721;21454685", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD6;Q9JKL2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0060396 growth hormone receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EPH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPT8-1", "uniprot_id": [ { "id": "CLIC5_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPT8", "type": "external" } ], "mass": 28299.0, "length": 251, "protein_name": "Chloride intracellular channel protein 5", "gene_name": "Clic5", "organism": "Rat", "refseq_name": "chloride intracellular channel protein 5", "refseq_ac": [ { "id": "NP_446055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446055", "type": "external" } ], "gene_names_uniprotkb": "Clic5", "gene_names_refseq": "Clic5", "protein_names_uniprotkb": "Chloride intracellular channel protein 5; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC5", "protein_names_refseq": "chloride intracellular channel 5; chloride intracellular channel protein 5; glutaredoxin-like oxidoreductase CLIC5", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 103 (Disease Ontology:DOID:0110464); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:94272)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17021174;20664558;24285636;26777142", "class_list": "", "function": "In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (By similarity). Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study identifies CLIC5 as a new component that is enriched in and necessary for foot process integrity and podocyte function in vivo., [RefSeq, PubMed]; The authors report the presence of unique dimorphic chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4 and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4, CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to adult cardiac mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0050885 neuromuscular process controlling balance;GO:0007601 visual perception;GO:0002024 diet induced thermogenesis;GO:0007605 sensory perception of sound;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EPT8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQV9-1", "uniprot_id": [ { "id": "CBPB2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQV9", "type": "external" } ], "mass": 48827.0, "length": 422, "protein_name": "Carboxypeptidase B2", "gene_name": "Cpb2", "organism": "Rat", "refseq_name": "carboxypeptidase B2 precursor", "refseq_ac": [ { "id": "NP_446069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446069", "type": "external" } ], "gene_names_uniprotkb": "Cpb2", "gene_names_refseq": "Cpb2", "protein_names_uniprotkb": "Carboxypeptidase B2; 3.4.17.20; CPR; CPU; Carboxypeptidase R; Carboxypeptidase U; TAFI; Thrombin-activable fibrinolysis inhibitor", "protein_names_refseq": "CPR; CPU; TAFI; carboxypeptidase B2 (plasma); carboxypeptidase B2 precursor; carboxypeptidase R; carboxypeptidase U; thrombin-activable fibrinolysis inhibitor", "tax_id": 10116, "disease": "nephrotic syndrome (Disease Ontology:DOID:1184); Behcet's disease (Disease Ontology:DOID:13241); thrombocytosis (Disease Ontology:DOID:2228); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:113936); (R-RNO-2022377); (R-RNO-977606)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11021404;11848438;21454685;24188431;28289017;37978153", "class_list": "", "function": "Arterial, platelet-rich thrombi in vivo are degraded by naturally generated plasminogen activators. TAFI may play a significant role in the control of these mechanisms., [RefSeq, PubMed]; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension., [RefSeq, PubMed]; Serum Proteomics Identified TAFI as a Potential Molecule Facilitating the Migration of Peripheral Monocytes to Damaged White Matter During Chronic Cerebral Hypoperfusion., [RefSeq, PubMed]; Thrombin-activatable fibrinolysis inhibitor is activated in an instant blood-mediated inflammatory reaction after intraportal islet transplant., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7V3;Q5BKB8", "ec_number_list": [ { "id": "3.4.17.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2", "type": "external" }, { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" }, { "id": "3.4.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.3", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0071333 cellular response to glucose stimulus;GO:0007596 blood coagulation;GO:0010757 negative regulation of plasminogen activation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER34-1", "uniprot_id": [ { "id": "ACON_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER34", "type": "external" } ], "mass": 85433.0, "length": 780, "protein_name": "Aconitate hydratase, mitochondrial", "gene_name": "Aco2", "organism": "Rat", "refseq_name": "aconitate hydratase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077374", "type": "external" } ], "gene_names_uniprotkb": "Aco2", "gene_names_refseq": "Aco2", "protein_names_uniprotkb": "Aconitate hydratase, mitochondrial; 4.2.1.3; Aconitase; Citrate hydro-lyase", "protein_names_refseq": "aconitase 2, mitochondrial; aconitate hydratase, mitochondrial precursor; aconitate hydratase, mitochondrial; citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene)", "tax_id": 10116, "disease": "infantile cerebellar-retinal degeneration (Disease Ontology:DOID:0050883); optic atrophy 9 (Disease Ontology:DOID:0111442); neurodegenerative disease (Disease Ontology:DOID:1289); optic nerve disease (Disease Ontology:DOID:1891); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (rno:79250); (R-RNO-71403); (R-RNO-9837999); (R-RNO-9854311)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16341586;19153662;22673903;24429287;26446791;27213235;34502162;36735737", "class_list": "", "function": "Catalyzes the isomerization of citrate to isocitrate via cis-aconitate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA. Publication Status: Online-Only, [RefSeq, PubMed]; Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity., [RefSeq, PubMed]; These results demonstrate the regulation of mitochondrial aconitase activity by protein kinase C-dependent phosphorylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6V3", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" } ], "go_molecular_function": "GO:0003994 aconitate hydratase activity;GO:0005506 iron ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0001889 liver development;GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0006102 isocitrate metabolic process;GO:0035900 response to isolation stress", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9ER34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES66-1", "uniprot_id": [ { "id": "CAN10_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES66", "type": "external" } ], "mass": 74527.0, "length": 666, "protein_name": "Calpain-10", "gene_name": "Capn10", "organism": "Rat", "refseq_name": "calpain-10", "refseq_ac": [ { "id": "NP_113861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113861", "type": "external" } ], "gene_names_uniprotkb": "Capn10", "gene_names_refseq": "Capn10", "protein_names_uniprotkb": "Calpain-10; 3.4.22.-; CANP 10; Calcium-activated neutral proteinase 10", "protein_names_refseq": "CANP 10; calcium-activated neutral proteinase 10; calpain-10", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); pancreatic cancer (Disease Ontology:DOID:1793); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:63834); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11375982;14646187;22568896", "class_list": "", "function": "'Calpain 10 (CAPN10) is reported linked with type 2 diabetes in certain human populations...' 'Levels of mRNA for type 2 diabetes-related genes such as ...CPN10 were quantified in WBC...in OLETF rats... known to initiate type 2 diabetes at 18 weeks...', [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Diabetes-induced renal mitochondrial dysfunction and renal injury may directly result from the loss of renal calpain 10, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.4.22.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.54", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0008092 cytoskeletal protein binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0032024 positive regulation of insulin secretion;GO:0032869 cellular response to insulin stimulus;GO:0032956 regulation of actin cytoskeleton organization;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ES66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES72-1", "uniprot_id": [ { "id": "CCN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES72", "type": "external" } ], "mass": 41687.0, "length": 379, "protein_name": "CCN family member 1", "gene_name": "Ccn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ccn1; Cyr61; Igfbp10", "gene_names_refseq": "", "protein_names_uniprotkb": "CCN family member 1; Cellular communication network factor 1; Cysteine-rich angiogenic inducer 61; IBP-10; IGF-binding protein 10; IGFBP-10; Insulin-like growth factor-binding protein 10; Protein CYR61", "protein_names_refseq": "", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); peripheral artery disease (Disease Ontology:DOID:0050830); atrial heart septal defect 1 (Disease Ontology:DOID:0110106); intracranial aneurysm (Disease Ontology:DOID:10941); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); capillary hemangioma (Disease Ontology:DOID:2725); high grade glioma (Disease Ontology:DOID:3070); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:83476); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10852911", "class_list": "", "function": "Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0032740 positive regulation of interleukin-17 production;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ES72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ19-1", "uniprot_id": [ { "id": "NHRF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ19", "type": "external" } ], "mass": 38830.0, "length": 356, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "gene_name": "Nherf1", "organism": "Rat", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1", "refseq_ac": [ { "id": "NP_067605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067605", "type": "external" } ], "gene_names_uniprotkb": "Nherf1; Nherf; Slc9a3r1", "gene_names_refseq": "Nherf1; Slc9a3r1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF1; EBP50; Ezrin-radixin-moesin-binding phosphoprotein 50; NHERF-1; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1", "protein_names_refseq": "EBP50; ERM-binding phosphoprotein; NHERF-1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; SLC9A3 regulator 1; ezrin-radixin-moesin-binding phosphoprotein 50; regulatory cofactor of Na(+)/H(+) exchanger; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); malignant renovascular hypertension (Disease Ontology:DOID:13730)", "pathway": " (rno:59114)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10859298;11457882;12444018;16396499;22673903;28515088;28669731;29491210", "class_list": "", "function": "Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity)., [UniProtKB]; The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Slc9a3r1 as a regulatory mechanism of Slc6a6-mediated GABA transport activity, [RefSeq, PubMed]; The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway., [RefSeq, PubMed]; These results suggest that decreased renal NHERF-1 expression contributes to the impaired dopamine-mediated inhibition of NKA in PTCs from animal models of hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045159 myosin II binding;GO:0031698 beta-2 adrenergic receptor binding;GO:0060090 molecular adaptor activity;GO:0050780 dopamine receptor binding;GO:0031800 type 3 metabotropic glutamate receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0030033 microvillus assembly;GO:0003096 renal sodium ion transport;GO:0034635 glutathione transport;GO:0097291 renal phosphate ion absorption", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJ19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKD6-1", "uniprot_id": [ { "id": "CLD5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKD6", "type": "external" } ], "mass": 23072.0, "length": 218, "protein_name": "Claudin-5", "gene_name": "Cldn5", "organism": "Rat", "refseq_name": "claudin-5", "refseq_ac": [ { "id": "NP_113889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113889", "type": "external" } ], "gene_names_uniprotkb": "Cldn5", "gene_names_refseq": "Cldn5", "protein_names_uniprotkb": "Claudin-5", "protein_names_refseq": "claudin-5", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:65131)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12403818;31151084;33417957;34359845;35318077;37992974", "class_list": "", "function": "Angelica sinensis polysaccharide improves rheumatoid arthritis by modifying the expression of intestinal Cldn5, Slit3 and Rgs18 through gut microbiota., [RefSeq, PubMed]; Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model. Publication Status: Online-Only, [RefSeq, PubMed]; Hyperglycemic levels in early stage of diabetic nephropathy affect differentially renal expression of claudins-2 and -5 by oxidative stress., [RefSeq, PubMed]; MUPP1 and claudin-5 colocalized in the incisures, and the COOH-terminal region of claudin-5 interacts with MUPP1 in a PSD-95/Disc Large/zona occludens (ZO)-1 (PDZ)-dependent manner in tight junctions, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space., [UniProtKB]; Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1 and CA-3 regions of a learned helplessness model of depression., [RefSeq, PubMed]; The expression of claudin-5 in the EAE group was negatively correlated with the inflammation scores. Levels of CCL26 in the serum and brain tissues and the number of CCR3-positive cells in the brain tissues were negatively correlated with the protein expression of claudin-5., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66H22", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0043220 Schmidt-Lanterman incisure", "go_biological_process": "GO:0120192 tight junction assembly;GO:0061028 establishment of endothelial barrier;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKD6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLT6-1", "uniprot_id": [ { "id": "BID_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLT6", "type": "external" } ], "mass": 22249.0, "length": 196, "protein_name": "BH3-interacting domain death agonist", "gene_name": "Bid", "organism": "Rat", "refseq_name": "BH3-interacting domain death agonist", "refseq_ac": [ { "id": "NP_073175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073175", "type": "external" } ], "gene_names_uniprotkb": "Bid", "gene_names_refseq": "Bid", "protein_names_uniprotkb": "BH3-interacting domain death agonist; BID; p11 BID; p13 BID; p15 BID; p22 BID", "protein_names_refseq": "BH3-interacting domain death agonist; apoptotic death agonist BID; desmocollin type 4; p22 BID", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); traumatic brain injury (Disease Ontology:DOID:0081292); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:64625); (R-RNO-111452); (R-RNO-111453); (R-RNO-114294); (R-RNO-75108)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "12787069;22673903;27584794;31533600", "class_list": "", "function": "ANXA1 interacts with p53 and promotes p53 transcriptional activity, which in turn regulates Bid expression. Publication Status: Online-Only, [RefSeq, PubMed]; Induces caspase activation and apoptosis (By similarity). Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c (By similarity)., [UniProtKB, UniProtKB]; Induces caspase activation and apoptosis. Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c., [UniProtKB, UniProtKB]; Induces caspases and apoptosis. Counters the protective effect of BCL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK60", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JLT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX73-1", "uniprot_id": [ { "id": "ARHG9_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX73", "type": "external" } ], "mass": 58157.0, "length": 493, "protein_name": "Rho guanine nucleotide exchange factor 9", "gene_name": "Arhgef9", "organism": "Rat", "refseq_name": "rho guanine nucleotide exchange factor 9 isoform 1", "refseq_ac": [ { "id": "NP_076447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076447", "type": "external" } ], "gene_names_uniprotkb": "Arhgef9", "gene_names_refseq": "Arhgef9", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 9; Collybistin; Rac/Cdc42 guanine nucleotide exchange factor 9", "protein_names_refseq": "Cdc42 guanine nucleotide exchange factor (GEF) 9; collybistin I; rac/Cdc42 guanine nucleotide exchange factor 9; rho guanine nucleotide exchange factor 9 isoform 1; rho guanine nucleotide exchange factor 9-like; rho guanine nucleotide exchange factor 9", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 8 (Disease Ontology:DOID:0080215)", "pathway": " (rno:66013); (R-RNO-193648); (R-RNO-416482); (R-RNO-9013148); (R-RNO-9013406); (R-RNO-977443)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "10607391;11727829;15215304;16616186;22659578;22778260;24297911;25678704;33316079", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Collybistin (Cb) knock-down induced impairment in GABAergic neurotransmission could be rescued by the expression of any of the Cb isoforms, independent of their C-termini or the presence of the SH3-domain in the N-terminal region., [RefSeq, PubMed]; Collybistin SH3-protein isoforms are expressed in the rat brain promoting gephyrin and GABA-A receptor clustering at GABAergic synapses., [RefSeq, PubMed]; Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin., [RefSeq, PubMed]; The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors, [RefSeq, PubMed]; Translocates gephyrin to submembrane microaggregates, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER22", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0014069 postsynaptic density", "go_biological_process": "GO:0043113 receptor clustering;GO:0099150 regulation of postsynaptic specialization assembly", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QX73-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY44-1", "uniprot_id": [ { "id": "ABCD2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY44", "type": "external" } ], "mass": 83468.0, "length": 741, "protein_name": "ATP-binding cassette sub-family D member 2", "gene_name": "Abcd2", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family D member 2", "refseq_ac": [ { "id": "NP_203503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203503", "type": "external" } ], "gene_names_uniprotkb": "Abcd2; Aldrp; Aldr", "gene_names_refseq": "ALDR; Abcd2", "protein_names_uniprotkb": "ATP-binding cassette sub-family D member 2; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy-related protein", "protein_names_refseq": "ATP-binding cassette sub-family D member 2; ATP-binding cassette, sub-family D (ALD), member 2; ATP-binding cassette, subfamily D (ALD), member 2; adrenoleukodystrophy-related protein", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (rno:84356); (R-RNO-1369062); (R-RNO-9603798)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11342107;16641100;21209459;28258215", "class_list": "", "function": "ABCD1 and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane, [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (By similarity). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transported in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (By similarity). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21209459). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21209459). However,the actual function of ABCD2 in vivo is still unclear (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3V7Z6", "ec_number_list": [ { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QY44-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYV0-1", "uniprot_id": [ { "id": "ADA15_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYV0", "type": "external" } ], "mass": 93308.0, "length": 864, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 15", "gene_name": "Adam15", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 15 isoform 3 precursor", "refseq_ac": [ { "id": "NP_064704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064704", "type": "external" } ], "gene_names_uniprotkb": "Adam15; Mdc15", "gene_names_refseq": "Adam15; MDC15; tMDCVI", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 15; 3.4.24.-; ADAM 15; CRII-7; MDC-15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; Metargidin", "protein_names_refseq": "ADAM 15; CRII-7; MDC-15; a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloproteinase domain 15 (metargidin); disintegrin and metalloproteinase domain-containing protein 15 isoform 3 precursor; disintegrin and metalloproteinase domain-containing protein 15; metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; tMDC VI", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:57025); (R-RNO-1474228); (R-RNO-8941237)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11102971;22230263;29393594", "class_list": "", "function": "Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain (By similarity)., [UniProtKB]; The present findings implicate ADAM15 in the processes of neuronal hypoxic injury, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q6P779", "ec_number_list": [ { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0031514 motile cilium;GO:0070062 extracellular exosome", "go_biological_process": "GO:1990910 response to hypobaric hypoxia;GO:0002418 immune response to tumor cell;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYV0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYW0-1", "uniprot_id": [ { "id": "AATF_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYW0", "type": "external" } ], "mass": 59497.0, "length": 523, "protein_name": "Protein AATF", "gene_name": "Aatf", "organism": "Rat", "refseq_name": "protein AATF", "refseq_ac": [ { "id": "NP_446172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446172", "type": "external" } ], "gene_names_uniprotkb": "Aatf", "gene_names_refseq": "Aatf; Ded", "protein_names_uniprotkb": "Protein AATF; Apoptosis-antagonizing transcription factor", "protein_names_refseq": "protein AATF", "tax_id": 10116, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)", "pathway": " (rno:114512)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10580117;14761944;19911006;22673903;23007641", "class_list": "", "function": "Che-1 plays an important role in neuronal apoptosis following traumatic brain injury., [RefSeq, PubMed]; Ectopic expression of AATF or a constitutively active form of AKT1 confers on cells resistance to ER stress-mediated cell death, whereas RNAi-mediated knockdown of AATF or AKT1 renders cells sensitive to ER stress., [RefSeq, PubMed]; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0043522 leucine zipper domain binding;GO:0048156 tau protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0007346 regulation of mitotic cell cycle;GO:0042254 ribosome biogenesis;GO:0042985 negative regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QYW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZA6-1", "uniprot_id": [ { "id": "CD151_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZA6", "type": "external" } ], "mass": 28355.0, "length": 253, "protein_name": "CD151 antigen", "gene_name": "Cd151", "organism": "Rat", "refseq_name": "CD151 antigen", "refseq_ac": [ { "id": "NP_071968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071968", "type": "external" } ], "gene_names_uniprotkb": "Cd151; Peta3", "gene_names_refseq": "Cd151", "protein_names_uniprotkb": "CD151 antigen; PETA-3; Platelet-endothelial tetraspan antigen 3", "protein_names_refseq": "CD151 antigen (Raph blood group); CD151 antigen-like; CD151 antigen; PETA-3; platelet-endothelial tetraspan antigen 3", "tax_id": 10116, "disease": "epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (rno:64315); (R-RNO-446107)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11682256;12782641;24090084;25544774;31186138;32285246;34022890", "class_list": "", "function": "CD151 Alleviates Early Blood-Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats., [RefSeq, PubMed]; Data indicate that the major contribution of cellular tetraspanins CD151 and Tspan8 to lymphatic metastasis formation relies on promoting motility and invasiveness., [RefSeq, PubMed]; Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of CD151 specifically attenuated adhesion-dependent activation of Ras., [RefSeq, PubMed]; Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes., [RefSeq, PubMed]; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis. Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process. Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity. Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes. Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005604 basement membrane", "go_biological_process": "GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0045807 positive regulation of endocytosis;GO:0044319 wound healing, spreading of cells;GO:0042098 T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9QZA6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZE3-1", "uniprot_id": [ { "id": "CATQ_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZE3", "type": "external" } ], "mass": 39052.0, "length": 343, "protein_name": "Cathepsin Q", "gene_name": "Ctsq", "organism": "Rat", "refseq_name": "cathepsin Q precursor", "refseq_ac": [ { "id": "NP_640355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640355", "type": "external" } ], "gene_names_uniprotkb": "Ctsq; Catq", "gene_names_refseq": "CatQ; Ctsq", "protein_names_uniprotkb": "Cathepsin Q; 3.4.22.-", "protein_names_refseq": "cathepsin Q precursor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:246147)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10673370;12054558", "class_list": "", "function": "Shows evolution in placental expression by gene duplication, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZE3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZN9-1", "uniprot_id": [ { "id": "CNR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZN9", "type": "external" } ], "mass": 39359.0, "length": 360, "protein_name": "Cannabinoid receptor 2", "gene_name": "Cnr2", "organism": "Rat", "refseq_name": "cannabinoid receptor 2 isoform 1", "refseq_ac": [ { "id": "NP_001157614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157614", "type": "external" } ], "gene_names_uniprotkb": "Cnr2", "gene_names_refseq": "CB-2; CB2C; CB2; CNR2C; Cnr2; rCB2", "protein_names_uniprotkb": "Cannabinoid receptor 2; CB-2; CB2; rCB2", "protein_names_refseq": "CB2 receptor; cannabinoid receptor 2 (macrophage); cannabinoid receptor 2 isoform 1; peripheral cannabinoid receptor", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); pancreatitis (Disease Ontology:DOID:4989); cocaine abuse (Disease Ontology:DOID:809); arthritis (Disease Ontology:DOID:848); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:57302); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10688601;11789671;11972997;12084572;12153574;12388547;16224028;18286196;33809047;33907944;35650684;36210711;38780511", "class_list": "", "function": "CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain., [RefSeq, PubMed]; CB2 receptors modulate seizure-induced expression of pro-inflammatory cytokines in the hippocampus but not neocortex., [RefSeq, PubMed]; Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet. Publication Status: Online-Only, [RefSeq, PubMed]; Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid receptors in the adrenals of hypertensive rats., [RefSeq, PubMed]; Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity)., [UniProtKB]; Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex., [RefSeq, PubMed]; Levels of the cannabinoid receptor type 2 in cells of macrophage lineage undergo major modulatory changes in relation to cell activation, [RefSeq, PubMed]; Protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity, [RefSeq, PubMed]; The rat peripheral cannabinoid receptor (rCB2) was cloned from a Sprague-Dawley rat spleen cDNA library and when translated, encodes a protein of 410 amino acids., [RefSeq, PubMed]; [Activation of cannabinoid receptor 2 alleviates acute lung injury in rats with lipopolysaccharide-induced sepsis]., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EP74", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004949 cannabinoid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QZN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0R3-1", "uniprot_id": [ { "id": "APEL_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0R3", "type": "external" } ], "mass": 8677.0, "length": 77, "protein_name": "Apelin", "gene_name": "Apln", "organism": "Rat", "refseq_name": "apelin preproprotein", "refseq_ac": [ { "id": "NP_113800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113800", "type": "external" } ], "gene_names_uniprotkb": "Apln; Apel", "gene_names_refseq": "Apel; Apln", "protein_names_uniprotkb": "Apelin; APJ endogenous ligand", "protein_names_refseq": "APJ endogenous ligand; apelin preproprotein; apelin, AGTRL1 ligand", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); atrial fibrillation (Disease Ontology:DOID:0060224); hypertension (Disease Ontology:DOID:10763); morbid obesity (Disease Ontology:DOID:11981); coronary stenosis (Disease Ontology:DOID:4248); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:58812); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10525157;10617103;11336787;11359874;26611206;37184417;37245722;37771168;37907514;39433147", "class_list": "", "function": "Apelin is expressed in intimal smooth muscle cells and promotes their phenotypic transition. Publication Status: Online-Only, [RefSeq, PubMed]; Apelin regulates mitochondrial dynamics by inhibiting Mst1-JNK-Drp1 signaling pathway to reduce neuronal apoptosis after spinal cord injury., [RefSeq, PubMed]; Apelin signalling in the periaqueductal grey matter alleviates capsaicin-evoked pulpal nocifensive behaviour and capsaicin-induced spatial learning and memory impairments in rat., [RefSeq, PubMed]; Effects of Apelin on the fibrosis of retinal tissues and Muller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway., [RefSeq, PubMed]; Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis (PubMed:11336787, PubMed:11359874, PubMed:26611206). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR (By similarity). Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (PubMed:26611206). On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor (PubMed:11359874). Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (PubMed:11336787). Involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (PubMed:11359874, PubMed:26611206). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (PubMed:10617103)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031704 apelin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001525 angiogenesis;GO:0010629 negative regulation of gene expression;GO:1904022 positive regulation of G protein-coupled receptor internalization;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R0R3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0W5-1", "uniprot_id": [ { "id": "ASIC5_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0W5", "type": "external" } ], "mass": 56464.0, "length": 495, "protein_name": "Bile acid-sensitive ion channel", "gene_name": "Asic5", "organism": "Rat", "refseq_name": "bile acid-sensitive ion channel", "refseq_ac": [ { "id": "NP_071563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071563", "type": "external" } ], "gene_names_uniprotkb": "Asic5; Accn5", "gene_names_refseq": "Accn5; Asic5; BASIC; Blinac; Inac", "protein_names_uniprotkb": "Bile acid-sensitive ion channel; Acid-sensing ion channel subunit family member 5; Amiloride-sensitive cation channel 5; BASIC; BLINaC; Brain-liver-intestine amiloride-sensitive Na(+) channel", "protein_names_refseq": "acid-sensing (proton-gated) ion channel family member 5; acid-sensing ion channel 5; amiloride-sensitive Na+ channel (BLINaC gene); amiloride-sensitive cation channel 5, intestinal; amiloride-sensitive sodium channel; bile acid-sensitive ion channel; brain-liver-intestine amiloride-sensitive Na(+) channel; inactivation no afterpotential C", "tax_id": 10116, "disease": "", "pathway": " (rno:63866); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10457052;12050153;20656685;22735174;23064163;25360526;27679529;34549327", "class_list": "", "function": "BASIC is strongly activated by ursodeoxycholic acid., [RefSeq, PubMed]; Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:10457052, PubMed:22735174, PubMed:27679529, PubMed:34549327). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:10457052, PubMed:20656685, PubMed:27679529). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (PubMed:25360526, PubMed:27679529). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; RBLINaC is opened by an unknown ligand whereas mBLINaC is a constitutively open epithelial Na(+) channel., [RefSeq, PubMed]; Regulation by N4WBP5A, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity;GO:0015252 proton channel activity;GO:0160228 bile acid-gated sodium channel activity;GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0035725 sodium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R0W5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T1-1", "uniprot_id": [ { "id": "BAF_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1T1", "type": "external" } ], "mass": 10045.0, "length": 89, "protein_name": "Barrier-to-autointegration factor", "gene_name": "Banf1", "organism": "Rat", "refseq_name": "barrier-to-autointegration factor", "refseq_ac": [ { "id": "NP_446083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446083", "type": "external" } ], "gene_names_uniprotkb": "Banf1; Baf; L2bp1", "gene_names_refseq": "Baf; Banf1; Bcrp1; L2bp1/Baf; L2bp1", "protein_names_uniprotkb": "Barrier-to-autointegration factor; LAP2-binding protein 1", "protein_names_refseq": "BAF nuclear assembly factor 1; Breakpoint cluster region protein, uterine leiomyoma, 1; LAP2-binding protein 1; Lap2 binding protein 1; barrier to autointegration factor 1; barrier to autointegration factor; barrier-to-autointegration factor; breakpoint cluster region protein 1", "tax_id": 10116, "disease": "Nestor-Guillermo progeria syndrome (Disease Ontology:DOID:0081334); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:114087); (R-RNO-2980766); (R-RNO-2995383)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10393804;15546916", "class_list": "", "function": "LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly, [RefSeq, PubMed]; Non-specific DNA-binding protein that plays key roles in mitotic nuclear reassembly, chromatin organization, DNA damage response, gene expression and intrinsic immunity against foreign DNA. Contains two non-specific double-stranded DNA (dsDNA)-binding sites which promote DNA cross-bridging. Plays a key role in nuclear membrane reformation at the end of mitosis by driving formation of a single nucleus in a spindle-independent manner. Transiently cross-bridges anaphase chromosomes via its ability to bridge distant DNA sites, leading to the formation of a dense chromatin network at the chromosome ensemble surface that limits membranes to the surface. Also acts as a negative regulator of innate immune activation by restricting CGAS activity toward self-DNA upon acute loss of nuclear membrane integrity. Outcompetes CGAS for DNA-binding, thereby preventing CGAS activation and subsequent damaging autoinflammatory responses. Also involved in DNA damage response: interacts with PARP1 in response to oxidative stress, thereby inhibiting the ADP-ribosyltransferase activity of PARP1. Involved in the recognition of exogenous dsDNA in the cytosol: associates with exogenous dsDNA immediately after its appearance in the cytosol at endosome breakdown and is required to avoid autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045071 negative regulation of viral genome replication;GO:0006325 chromatin organization;GO:0007084 mitotic nuclear membrane reassembly;GO:0010836 negative regulation of protein ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1T1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1F1-1", "uniprot_id": [ { "id": "DEF3B_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1F1", "type": "external" } ], "mass": 9353.0, "length": 87, "protein_name": "Neutrophil antibiotic peptide NP-3B", "gene_name": "", "organism": "Rat", "refseq_name": "neutrophil antibiotic peptide NP-3B precursor", "refseq_ac": [ { "id": "NP_001073367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073367", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "NP-3a; NP-3b; NP-3; Np3; Ratnp-3b", "protein_names_uniprotkb": "Neutrophil antibiotic peptide NP-3B; Neutrophil defensin 3; RatNP-3b", "protein_names_refseq": "Neutrophil antibiotic peptide NP-3A; defensin 3a; defensin 3b; defensin NP-3; defensin RatNP-3; neutrophil antibiotic peptide NP-3B precursor; neutrophil antibiotic peptide NP-3B; neutrophil antibiotic peptide NP-3; neutrophil defensin 3; ratNP-3a", "tax_id": 10116, "disease": "", "pathway": " (rno:498659); (R-RNO-1461973); (R-RNO-1462054); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2543629", "class_list": "", "function": "Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1F1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1L1-1", "uniprot_id": [ { "id": "CLD7_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1L1", "type": "external" } ], "mass": 22432.0, "length": 211, "protein_name": "Claudin-7", "gene_name": "Cldn7", "organism": "Rat", "refseq_name": "claudin-7", "refseq_ac": [ { "id": "NP_113890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113890", "type": "external" } ], "gene_names_uniprotkb": "Cldn7", "gene_names_refseq": "Cldn7; cld-7", "protein_names_uniprotkb": "Claudin-7", "protein_names_refseq": "claudin-7", "tax_id": 10116, "disease": "", "pathway": " (rno:65132)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16054130;17187413;17651736;23180307;23390083;27120791", "class_list": "", "function": "An association between claudin-7 and EpCAM/Tacstd1 is noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract., [RefSeq, PubMed]; Claudin 7 demonstrates a distinct basal and lateral localisation in the uterine luminal and glandular epithelium throughout early pregnancy, [RefSeq, PubMed]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]; Cld7 supports tumorigenic features of EpC by provoking EpC cleavage and thereby its cotranscription factor activity, [RefSeq, PubMed]; Pancreatic adenocarcinoma cell line ASMLL-claudin7 (cld7) knockdown (kd) and ASML-cld7 mutated palmitoylation cells show reduced motility and invasiveness., [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space., [UniProtKB]; We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp)., [RefSeq, PubMed]; Wnk4 phosphorylates ser(206) of Cldn7 and promotes paracellular Cl-ion permeability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1J0", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0030054 cell junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0031333 negative regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z1L1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Z8-1", "uniprot_id": [ { "id": "DHCR7_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Z8", "type": "external" } ], "mass": 54155.0, "length": 471, "protein_name": "7-dehydrocholesterol reductase", "gene_name": "Dhcr7", "organism": "Rat", "refseq_name": "7-dehydrocholesterol reductase", "refseq_ac": [ { "id": "NP_071784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071784", "type": "external" } ], "gene_names_uniprotkb": "Dhcr7", "gene_names_refseq": "Dhcr7", "protein_names_uniprotkb": "7-dehydrocholesterol reductase; 1.3.1.21; 3.3.2.11; 7-DHC reductase; Cholesterol-5,6-epoxide hydrolase subunit DHCR7; Sterol Delta(7)-reductase", "protein_names_refseq": "7-DHC reductase; 7-dehydrocholesterol reductase; cholesterol-5,6-epoxide hydrolase subunit DHCR7; sterol Delta(7)-reductase", "tax_id": 10116, "disease": "Behcet's disease (Disease Ontology:DOID:13241); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692)", "pathway": " (rno:64191); (R-RNO-6807047); (R-RNO-9969901)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10329655;12031495;37329988;38843836", "class_list": "", "function": "Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis., [UniProtKB, UniProtKB]; Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between cholestenol Delta-isomerase/EBP and DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention., [RefSeq, PubMed]; Oxidoreductase that catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "5.3.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.5", "type": "external" }, { "id": "3.3.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.11", "type": "external" }, { "id": "1.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0047598 7-dehydrocholesterol reductase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0050661 NADP binding;GO:0033963 cholesterol-5,6-oxide hydrolase activity;GO:0050613 Delta14-sterol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0016126 sterol biosynthetic process;GO:0030324 lung development;GO:0045540 regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z2Z8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4KWA1-1", "uniprot_id": [ { "id": "KRBBA_RAT", "url": "https://www.uniprot.org/uniprot/A4KWA1", "type": "external" } ], "mass": 24772.0, "length": 223, "protein_name": "Killer cell lectin-like receptor subfamily B member 1B allele A", "gene_name": "Klrb1a; Klrb1b", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily B member 1B", "refseq_ac": [ { "id": "NP_775414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775414", "type": "external" } ], "gene_names_uniprotkb": "Klrb1a; Klrb1b; Klrb1a; Nkrp1b; Nkrp1c; RGD2301395", "gene_names_refseq": "Klrb1b; Nkr-p1b; Nkrp1b", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1B allele A; CD161 antigen-like family member B; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344", "protein_names_refseq": "CD161 antigen-like family member B; killer cell lectin like receptor B1B; killer cell lectin-like receptor subfamily B member 1B; natural killer cell surface protein NKR-P1B", "tax_id": 10116, "disease": "", "pathway": " (rno:25192)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16547249;17462921", "class_list": "", "function": "Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62983", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A4KWA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPN1-1", "uniprot_id": [ { "id": "HLX_RAT", "url": "https://www.uniprot.org/uniprot/A0JPN1", "type": "external" } ], "mass": 50027.0, "length": 476, "protein_name": "H2.0-like homeobox protein", "gene_name": "Hlx", "organism": "Rat", "refseq_name": "H2.0-like homeobox protein", "refseq_ac": [ { "id": "NP_001071142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071142", "type": "external" } ], "gene_names_uniprotkb": "Hlx; Hlx1", "gene_names_refseq": "Hlx1; Hlx", "protein_names_uniprotkb": "H2.0-like homeobox protein; Homeobox protein HLX1", "protein_names_refseq": "H2.0-like homeo box 1; H2.0-like homeobox protein; homeobox protein HLX1", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815)", "pathway": " (rno:364069)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPN1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5Q5-1", "uniprot_id": [ { "id": "KDM4D_RAT", "url": "https://www.uniprot.org/uniprot/A1A5Q5", "type": "external" } ], "mass": 57188.0, "length": 510, "protein_name": "Lysine-specific demethylase 4D", "gene_name": "Kdm4d", "organism": "Rat", "refseq_name": "lysine-specific demethylase 4D", "refseq_ac": [ { "id": "NP_001073180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073180", "type": "external" } ], "gene_names_uniprotkb": "Kdm4d; Jhdm3d; Jmjd2d", "gene_names_refseq": "Kdm4d", "protein_names_uniprotkb": "Lysine-specific demethylase 4D; 1.14.11.66; JmjC domain-containing histone demethylation protein 3D; Jumonji domain-containing protein 2D; [histone H3]-trimethyl-L-lysine(9) demethylase 4D", "protein_names_refseq": "[histone H3]-trimethyl-L-lysine(9) demethylase 4D; jmjC domain-containing histone demethylation protein 3D; jumonji domain-containing protein 2D; lysine (K)-specific demethylase 4D; lysine-specific demethylase 4D", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (rno:689582); (R-RNO-3214842)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003684 damaged DNA binding;GO:0031490 chromatin DNA binding;GO:0032452 histone demethylase activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0035861 site of double-strand break;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5Q5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5S3-1", "uniprot_id": [ { "id": "GPR18_RAT", "url": "https://www.uniprot.org/uniprot/A1A5S3", "type": "external" } ], "mass": 37556.0, "length": 331, "protein_name": "N-arachidonyl glycine receptor", "gene_name": "Gpr18", "organism": "Rat", "refseq_name": "N-arachidonyl glycine receptor", "refseq_ac": [ { "id": "NP_001073178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073178", "type": "external" } ], "gene_names_uniprotkb": "Gpr18", "gene_names_refseq": "Gpr18", "protein_names_uniprotkb": "N-arachidonyl glycine receptor; G protein-coupled receptor 18; NAGly receptor", "protein_names_refseq": "N-arachidonyl glycine receptor; NAGly receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:679957); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24431468;32197469;32949767", "class_list": "", "function": "A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems. Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (By similarity). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Participates also in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GPR18-NAGly system in periaqueductal gray and chronic neuropathic pain., [RefSeq, PubMed]; The role of a novel cannabinoid receptor GPR18, espressed in the rostral ventrolateral medulla, in central blood pressure control., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0002300 CD8-positive, alpha-beta intraepithelial T cell differentiation;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032720 negative regulation of tumor necrosis factor production;GO:0002305 CD8-positive, gamma-delta intraepithelial T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1A5S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3QPB9-1", "uniprot_id": [ { "id": "IL21_RAT", "url": "https://www.uniprot.org/uniprot/A3QPB9", "type": "external" } ], "mass": 17065.0, "length": 146, "protein_name": "Interleukin-21", "gene_name": "Il21", "organism": "Rat", "refseq_name": "interleukin-21 precursor", "refseq_ac": [ { "id": "NP_001102413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102413", "type": "external" } ], "gene_names_uniprotkb": "Il21", "gene_names_refseq": "IL-21; Il21", "protein_names_uniprotkb": "Interleukin-21; IL-21", "protein_names_refseq": "interleukin-21 precursor", "tax_id": 10116, "disease": "common variable immunodeficiency 11 (Disease Ontology:DOID:0081153); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); allergic disease (Disease Ontology:DOID:1205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); autoimmune hepatitis (Disease Ontology:DOID:2048); asthma (Disease Ontology:DOID:2841); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); periodontal disease (Disease Ontology:DOID:3388); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684); neuromyelitis optica (Disease Ontology:DOID:8869); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:365769); (R-RNO-9020958)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "38194747;38728237", "class_list": "", "function": "Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis., [RefSeq, PubMed]; Role of Interleukin-21 in retinal ischemia-reperfusion injury: Unveiling the impact on retinal ganglion cell apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005134 interleukin-2 receptor binding;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0032740 positive regulation of interleukin-17 production;GO:0008284 positive regulation of cell population proliferation;GO:0001819 positive regulation of cytokine production;GO:0002314 germinal center B cell differentiation;GO:0030890 positive regulation of B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A3QPB9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7VL23-1", "uniprot_id": [ { "id": "KCMB3_RAT", "url": "https://www.uniprot.org/uniprot/A7VL23", "type": "external" } ], "mass": 26447.0, "length": 239, "protein_name": "Calcium-activated potassium channel subunit beta-3", "gene_name": "Kcnmb3", "organism": "Rat", "refseq_name": "calcium-activated potassium channel subunit beta-3", "refseq_ac": [ { "id": "NP_001098030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098030", "type": "external" } ], "gene_names_uniprotkb": "Kcnmb3", "gene_names_refseq": "Kcnmb3", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-3; Calcium-activated potassium channel subfamily M subunit beta-3; Maxi K channel subunit beta-3", "protein_names_refseq": "calcium-activated potassium channel subfamily M subunit beta-3; calcium-activated potassium channel subunit beta-3; maxi K channel subunit beta-3; potassium channel subfamily M regulatory beta subunit 3; potassium large conductance calcium-activated channel, subfamily M beta member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:310303); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7VL23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BMZ3-1", "uniprot_id": [ { "id": "GIMD1_RAT", "url": "https://www.uniprot.org/uniprot/B0BMZ3", "type": "external" } ], "mass": 24343.0, "length": 216, "protein_name": "GTPase IMAP family member GIMD1", "gene_name": "Gimd1", "organism": "Rat", "refseq_name": "GTPase IMAP family member GIMD1", "refseq_ac": [ { "id": "NP_001107254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107254", "type": "external" } ], "gene_names_uniprotkb": "Gimd1", "gene_names_refseq": "Gimd1", "protein_names_uniprotkb": "GTPase IMAP family member GIMD1; GIMAP family P-loop NTPase domain-containing protein 1", "protein_names_refseq": "GIMAP family P-loop NTPase domain-containing protein 1; GTPase IMAP family member GIMD1", "tax_id": 10116, "disease": "", "pathway": " (rno:362042)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BMZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN13-1", "uniprot_id": [ { "id": "INSY1_RAT", "url": "https://www.uniprot.org/uniprot/B0BN13", "type": "external" } ], "mass": 31654.0, "length": 291, "protein_name": "Inhibitory synaptic factor 1", "gene_name": "Insyn1", "organism": "Rat", "refseq_name": "inhibitory synaptic factor 1", "refseq_ac": [ { "id": "NP_001107263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107263", "type": "external" } ], "gene_names_uniprotkb": "Insyn1", "gene_names_refseq": "Insyn1; RGD1562618", "protein_names_uniprotkb": "Inhibitory synaptic factor 1; InSyn1", "protein_names_refseq": "UPF0583 protein C15orf59 homolog; inhibitory synaptic factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:501007)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0014069 postsynaptic density;GO:0099572 postsynaptic specialization", "go_biological_process": "GO:0060080 inhibitory postsynaptic potential;GO:0099565 chemical synaptic transmission, postsynaptic;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN44-1", "uniprot_id": [ { "id": "P5I13_RAT", "url": "https://www.uniprot.org/uniprot/B0BN44", "type": "external" } ], "mass": 42710.0, "length": 388, "protein_name": "Tumor protein p53-inducible protein 13", "gene_name": "Tp53i13", "organism": "Rat", "refseq_name": "tumor protein p53-inducible protein 13 precursor", "refseq_ac": [ { "id": "NP_001099288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099288", "type": "external" } ], "gene_names_uniprotkb": "Tp53i13; Trp53i13", "gene_names_refseq": "RGD1559818; Tp53i13; Trp53i13", "protein_names_uniprotkb": "Tumor protein p53-inducible protein 13", "protein_names_refseq": "transformation related protein 53 inducible protein 13; tumor protein p53-inducible protein 13 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:287550)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0009411 response to UV;GO:0009410 response to xenobiotic stimulus;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNG0-1", "uniprot_id": [ { "id": "EMC2_RAT", "url": "https://www.uniprot.org/uniprot/B0BNG0", "type": "external" } ], "mass": 34870.0, "length": 297, "protein_name": "ER membrane protein complex subunit 2", "gene_name": "Emc2", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 2", "refseq_ac": [ { "id": "NP_001107257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107257", "type": "external" } ], "gene_names_uniprotkb": "Emc2; Ttc35", "gene_names_refseq": "Emc2; RGD1310430; Ttc35", "protein_names_uniprotkb": "ER membrane protein complex subunit 2; TPR repeat protein 35; Tetratricopeptide repeat protein 35", "protein_names_refseq": "ER membrane protein complex subunit 2; TPR repeat protein 35; tetratricopeptide repeat domain 35; tetratricopeptide repeat protein 35", "tax_id": 10116, "disease": "", "pathway": " (rno:362905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042406 extrinsic component of endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNL4-1", "uniprot_id": [ { "id": "HRG1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNL4", "type": "external" } ], "mass": 16615.0, "length": 146, "protein_name": "Heme transporter HRG1", "gene_name": "Slc48a1", "organism": "Rat", "refseq_name": "heme transporter HRG1", "refseq_ac": [ { "id": "NP_001120928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120928", "type": "external" } ], "gene_names_uniprotkb": "Slc48a1; Hrg1", "gene_names_refseq": "HRG-1; Hrg1; Slc48a1", "protein_names_uniprotkb": "Heme transporter HRG1; HRG-1; Heme-responsive gene 1 protein homolog; Solute carrier family 48 member 1", "protein_names_refseq": "Heme-responsive gene 1 protein homolog; heme transporter HRG1; solute carrier family 48 (heme transporter), member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:300191)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19875448", "class_list": "", "function": "HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells., [RefSeq, PubMed]; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KR77", "ec_number_list": [], "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0061474 phagolysosome membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0015886 heme transport;GO:0042168 heme metabolic process;GO:0097037 heme export;GO:0140357 heme export from vacuole to cytoplasm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BNL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNM1-1", "uniprot_id": [ { "id": "NNRE_RAT", "url": "https://www.uniprot.org/uniprot/B0BNM1", "type": "external" } ], "mass": 30891.0, "length": 282, "protein_name": "NAD(P)H-hydrate epimerase", "gene_name": "Naxe", "organism": "Rat", "refseq_name": "NAD(P)H-hydrate epimerase precursor", "refseq_ac": [ { "id": "NP_001386156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386156", "type": "external" } ], "gene_names_uniprotkb": "Naxe; Aibp; Apoa1bp", "gene_names_refseq": "AI-BP; Apoa1bp; Naxe", "protein_names_uniprotkb": "NAD(P)H-hydrate epimerase; 5.1.99.6; AI-BP; Apolipoprotein A-I-binding protein; NAD(P)HX epimerase", "protein_names_refseq": "NAD(P)H-hydrate epimerase precursor; NAD(P)H-hydrate epimerase; apolipoprotein A-I-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:295229); (R-RNO-196807)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24611804", "class_list": "", "function": "After partial purification, quantification of NAD(P)HX dehydratase and epimerase activities in rat tissues indicates that both CARDKD (carbohydrate kinase domain protein) and AIBP protein are widely distributed., [RefSeq, PubMed]; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity)., [UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.99.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.6", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0052856 NAD(P)HX epimerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005929 cilium", "go_biological_process": "GO:0006869 lipid transport;GO:0016525 negative regulation of angiogenesis;GO:0002040 sprouting angiogenesis;GO:0010874 regulation of cholesterol efflux;GO:0046496 nicotinamide nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BNM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNM9-1", "uniprot_id": [ { "id": "GLTP_RAT", "url": "https://www.uniprot.org/uniprot/B0BNM9", "type": "external" } ], "mass": 23704.0, "length": 209, "protein_name": "Glycolipid transfer protein", "gene_name": "GLTP", "organism": "Rat", "refseq_name": "glycolipid transfer protein", "refseq_ac": [ { "id": "NP_001127885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127885", "type": "external" } ], "gene_names_uniprotkb": "GLTP", "gene_names_refseq": "Gltp; RGD1564442", "protein_names_uniprotkb": "Glycolipid transfer protein; GLTP", "protein_names_refseq": "glycolipid transfer protein", "tax_id": 10116, "disease": "", "pathway": " (rno:288707); (R-RNO-9845576)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:1902387 ceramide 1-phosphate binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:0017089 glycolipid transfer activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035627 ceramide transport;GO:0035902 response to immobilization stress;GO:0120009 intermembrane lipid transfer;GO:0046317 regulation of glucosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BNM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H222-1", "uniprot_id": [ { "id": "GORAB_RAT", "url": "https://www.uniprot.org/uniprot/B1H222", "type": "external" } ], "mass": 41632.0, "length": 368, "protein_name": "RAB6-interacting golgin", "gene_name": "Gorab", "organism": "Rat", "refseq_name": "RAB6-interacting golgin", "refseq_ac": [ { "id": "NP_001094033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094033", "type": "external" } ], "gene_names_uniprotkb": "Gorab; Ntklbp1; Scyl1bp1", "gene_names_refseq": "Gorab; Scyl1bp1", "protein_names_uniprotkb": "RAB6-interacting golgin; N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKL-binding protein 1; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1", "protein_names_refseq": "N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKL-binding protein 1; RAB6-interacting golgin; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1", "tax_id": 10116, "disease": "geroderma osteodysplasticum (Disease Ontology:DOID:0111266)", "pathway": " (rno:304923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23051735;23479292;26572638", "class_list": "", "function": "Both SCYL1-bp1 and Pirh2 were colocalized with active caspase-3., [RefSeq, PubMed]; Plays a role in the organization and function of the Golgi apparatus. Involved in protein post-translational modification, particularly glycosylation of extracellular matrix proteins. Functions at the trans-Golgi by cooperating with SCYL1 to promote COPI coat assembly into discrete functional domains, supporting Golgi organization and trafficking., [UniProtKB, UniProtKB]; SCYL1BP1 participated in Schwann cell (SC) differentiation and neurite outgrowth in the sciatic nerve after crush by regulating the RhoA pathway., [RefSeq, PubMed]; These data strongly suggested that SCYL1BP1 is a novel transcriptional activator in neurite outgrowth by directly modulating the Mdm2/p53-dependent pathway, which might play an important role in CNS development and axonal regeneration after injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RK15", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:1905515 non-motile cilium assembly;GO:0031069 hair follicle morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "B1H222-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H285-1", "uniprot_id": [ { "id": "KBTB8_RAT", "url": "https://www.uniprot.org/uniprot/B1H285", "type": "external" } ], "mass": 66322.0, "length": 575, "protein_name": "Kelch repeat and BTB domain-containing protein 8", "gene_name": "Kbtbd8", "organism": "Rat", "refseq_name": "kelch repeat and BTB domain-containing protein 8", "refseq_ac": [ { "id": "NP_001102720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102720", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd8", "gene_names_refseq": "Kbtbd8; RGD1563166", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 8", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 8; kelch repeat and BTB domain-containing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:500262); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0014029 neural crest formation;GO:0006417 regulation of translation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0014032 neural crest cell development;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1H285-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC86-1", "uniprot_id": [ { "id": "MPPE1_RAT", "url": "https://www.uniprot.org/uniprot/B1WC86", "type": "external" } ], "mass": 45654.0, "length": 394, "protein_name": "Metallophosphoesterase 1", "gene_name": "Mppe1", "organism": "Rat", "refseq_name": "metallophosphoesterase 1", "refseq_ac": [ { "id": "NP_001101905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101905", "type": "external" } ], "gene_names_uniprotkb": "Mppe1; Pgap5", "gene_names_refseq": "Mppe1", "protein_names_uniprotkb": "Metallophosphoesterase 1; 3.1.-.-; Post-GPI attachment to proteins factor 5", "protein_names_refseq": "metallophosphoesterase 1; post-GPI attachment to proteins factor 5", "tax_id": 10116, "disease": "", "pathway": " (rno:361344)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate. Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0062050 GPI-mannose ethanolamine phosphate phosphodiesterase activity;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC97-1", "uniprot_id": [ { "id": "KCTD7_RAT", "url": "https://www.uniprot.org/uniprot/B1WC97", "type": "external" } ], "mass": 33093.0, "length": 289, "protein_name": "BTB/POZ domain-containing protein KCTD7", "gene_name": "Kctd7", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD7", "refseq_ac": [ { "id": "NP_001121666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121666", "type": "external" } ], "gene_names_uniprotkb": "Kctd7", "gene_names_refseq": "Kctd7", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD7", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD7; potassium channel tetramerisation domain containing 7", "tax_id": 10116, "disease": "progressive myoclonus epilepsy 3 (Disease Ontology:DOID:0111446)", "pathway": " (rno:688993); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the control of excitability of cortical neurons., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060081 membrane hyperpolarization;GO:0030007 intracellular potassium ion homeostasis;GO:0032411 positive regulation of transporter activity;GO:0090461 intracellular glutamate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC97-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUY0-1", "uniprot_id": [ { "id": "MA1B1_RAT", "url": "https://www.uniprot.org/uniprot/B2GUY0", "type": "external" } ], "mass": 74895.0, "length": 657, "protein_name": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "gene_name": "Man1b1", "organism": "Rat", "refseq_name": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "refseq_ac": [ { "id": "NP_001102666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102666", "type": "external" } ], "gene_names_uniprotkb": "Man1b1", "gene_names_refseq": "ERMan1; Man1b1; RGD1563595", "protein_names_uniprotkb": "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; 3.2.1.113; ER alpha-1,2-mannosidase; ER mannosidase 1; ERMan1; Mannosidase alpha class 1B member 1", "protein_names_refseq": "ER alpha-1,2-mannosidase; ER mannosidase 1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase", "tax_id": 10116, "disease": "Rafiq syndrome (Disease Ontology:DOID:0081097)", "pathway": " (rno:499751)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.113", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.113", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:0140277 endoplasmic reticulum N-glycan trimming", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2GUY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV54-1", "uniprot_id": [ { "id": "NCEH1_RAT", "url": "https://www.uniprot.org/uniprot/B2GV54", "type": "external" } ], "mass": 45822.0, "length": 408, "protein_name": "Neutral cholesterol ester hydrolase 1", "gene_name": "Nceh1", "organism": "Rat", "refseq_name": "neutral cholesterol ester hydrolase 1", "refseq_ac": [ { "id": "NP_001120996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120996", "type": "external" } ], "gene_names_uniprotkb": "Nceh1; Aadacl1", "gene_names_refseq": "Aadacl1; Nceh1; RGD1311104", "protein_names_uniprotkb": "Neutral cholesterol ester hydrolase 1; 2-acetyl MAGE hydrolase; 3.1.1.-; 3.1.1.71; Acetylalkylglycerol acetylhydrolase; Arylacetamide deacetylase-like 1; NCEH", "protein_names_refseq": "2-acetyl MAGE hydrolase; NCEH; acetylalkylglycerol acetylhydrolase; arylacetamide deacetylase-like 1; neutral cholesterol ester hydrolase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:294930); (R-RNO-8964038)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (By similarity). May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0017171 serine hydrolase activity;GO:0047378 acetylalkylglycerol acetylhydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0006805 xenobiotic metabolic process;GO:0006470 protein dephosphorylation;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B2GV54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYU8-1", "uniprot_id": [ { "id": "LYRM1_RAT", "url": "https://www.uniprot.org/uniprot/B2RYU8", "type": "external" } ], "mass": 14259.0, "length": 122, "protein_name": "LYR motif-containing protein 1", "gene_name": "Lyrm1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lyrm1", "gene_names_refseq": "", "protein_names_uniprotkb": "LYR motif-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May promote cell proliferation and inhibition of apoptosis of preadipocytes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYU8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88483-1", "uniprot_id": [ { "id": "PDP1_RAT", "url": "https://www.uniprot.org/uniprot/O88483", "type": "external" } ], "mass": 61180.0, "length": 538, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial", "gene_name": "Pdp1", "organism": "Rat", "refseq_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_062245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062245", "type": "external" } ], "gene_names_uniprotkb": "Pdp1; Ppm2c", "gene_names_refseq": "PDPC 1; Pdp1; Ppm2c", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; 3.1.3.43; PDP 1; PDPC 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1", "protein_names_refseq": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; protein phosphatase 2C, magnesium dependent, catalytic subunit; pyruvate dehydrogenase phosphatase isoenzyme 1; pyruvate dehyrogenase phosphatase catalytic subunit 1", "tax_id": 10116, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54705); (R-RNO-204174)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15210124;15367397;17532339;18716035;22884618;35148687;9651365", "class_list": "", "function": "Asp445 might be involved in the control of interactions between PDP1c and the protein substrate pyruvate dehydrogenase, [RefSeq, PubMed]; Divergent alterations of PDP1 mRNA expression were found in different brain regions following traumatic brain injury., [RefSeq, PubMed]; MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Results report the crystal structure of the rat pyruvate dehydrogenase phosphatase 1 catalytic subunit at 1.8 A resolution., [RefSeq, PubMed]; Results suggest that decreased PDP activity in oxidative skeletal muscles may play a role in the impairment of carbohydrate metabolism in obese rats, which is reversible with endurance training., [RefSeq, PubMed]; Role of PP2C and AMPK in the derangements of cardiac lipid metabolism in obesity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1J4;F1LP63", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0000287 magnesium ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0035970 peptidyl-threonine dephosphorylation;GO:0140176 positive regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88483-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60571-1", "uniprot_id": [ { "id": "PANX2_RAT", "url": "https://www.uniprot.org/uniprot/P60571", "type": "external" } ], "mass": 74434.0, "length": 674, "protein_name": "Pannexin-2", "gene_name": "Panx2", "organism": "Rat", "refseq_name": "pannexin-2", "refseq_ac": [ { "id": "NP_955441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955441", "type": "external" } ], "gene_names_uniprotkb": "Panx2; Panx; Px2", "gene_names_refseq": "Panx2", "protein_names_uniprotkb": "Pannexin-2", "protein_names_refseq": "pannexin-2", "tax_id": 10116, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:362979); (R-RNO-112303)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "14597722;16616526;17692470;19009624;21467198;22301733;28390953", "class_list": "", "function": "Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP., [RefSeq, PubMed]; Pannexin 2 is expressed in both endothelium and smooth muscle of middle cerebral arteries., [RefSeq, PubMed]; Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons, [RefSeq, PubMed]; Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells., [RefSeq, PubMed]; Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in article text], [RefSeq, PubMed]; Structural component of the gap junctions and the hemichannels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions., [RefSeq, PubMed]; We noted the expression of Px2 in astrocytes of reactive gliosis in the hippocampus after I/R injury. Px2 mediates the formation of hemichannels for the release of signaling molecules devoted to influence the cellular metabolism ., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity;GO:0005243 gap junction channel activity;GO:0015267 channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005921 gap junction", "go_biological_process": "GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P60571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97603-1", "uniprot_id": [ { "id": "NEO1_RAT", "url": "https://www.uniprot.org/uniprot/P97603", "type": "external" } ], "mass": 150638.0, "length": 1377, "protein_name": "Neogenin", "gene_name": "Neo1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Neo1; Ngn", "gene_names_refseq": "", "protein_names_uniprotkb": "Neogenin", "protein_names_refseq": "", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:81735)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;24090084;38843836;8861902", "class_list": "", "function": "Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding;GO:0070700 BMP receptor binding;GO:0039706 co-receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097708 intracellular vesicle;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0048679 regulation of axon regeneration;GO:0001764 neuron migration;GO:0006355 regulation of DNA-templated transcription;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P97603-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20070-1", "uniprot_id": [ { "id": "NB5R3_RAT", "url": "https://www.uniprot.org/uniprot/P20070", "type": "external" } ], "mass": 34175.0, "length": 301, "protein_name": "NADH-cytochrome b5 reductase 3", "gene_name": "Cyb5r3", "organism": "Rat", "refseq_name": "NADH-cytochrome b5 reductase 3", "refseq_ac": [ { "id": "NP_620232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620232", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r3; Dia1", "gene_names_refseq": "Cyb5r3; Dia1; Nadhcb5; RNNADHCB5", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 3; 1.6.2.2; B5R; Cytochrome b5 reductase; Diaphorase-1", "protein_names_refseq": "B5R; Diaphorase (NADH) (cytochrome b-5 reductase); NADH-cytochrome b5 reductase 3; diaphorase-1", "tax_id": 10116, "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); methemoglobinemia (Disease Ontology:DOID:10783); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:25035); (R-RNO-196836); (R-RNO-211945); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "11695905;1577871;2391344;2498303;25850901;28100784;29706024;3174630;34502162;8143727;8812833;8978818", "class_list": "", "function": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results highlight the importance of CYB5R3 and NQO1, two NAD(+) producers, for the promotion of health and extended lifespan, [RefSeq, PubMed]; Results point out the enrichment of cytochrome b 5 reductase isoform 3/cytochrome b 5 system in neuronal cells and structures of the cerebellum and brain stem., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64569;Q64720", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016208 AMP binding;GO:0043531 ADP binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0006809 nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P20070-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M1K5-1", "uniprot_id": [ { "id": "PED1B_RAT", "url": "https://www.uniprot.org/uniprot/Q2M1K5", "type": "external" } ], "mass": 49975.0, "length": 432, "protein_name": "PC-esterase domain-containing protein 1B", "gene_name": "Pced1b", "organism": "Rat", "refseq_name": "PC-esterase domain-containing protein 1B", "refseq_ac": [ { "id": "NP_001034543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034543", "type": "external" } ], "gene_names_uniprotkb": "Pced1b; Fam113b", "gene_names_refseq": "Fam113b; Pced1b; RGD1561028", "protein_names_uniprotkb": "PC-esterase domain-containing protein 1B; Protein FAM113B", "protein_names_refseq": "PC-esterase domain-containing protein 1B; family with sequence similarity 113, member B; protein FAM113B; translation initiation factor IF-2-like", "tax_id": 10116, "disease": "", "pathway": " (rno:315283)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2M1K5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C6K2K4-1", "uniprot_id": [ { "id": "NETO2_RAT", "url": "https://www.uniprot.org/uniprot/C6K2K4", "type": "external" } ], "mass": 59342.0, "length": 525, "protein_name": "Neuropilin and tolloid-like protein 2", "gene_name": "Neto2", "organism": "Rat", "refseq_name": "neuropilin and tolloid-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001100887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100887", "type": "external" } ], "gene_names_uniprotkb": "Neto2; Btcl2", "gene_names_refseq": "Neto2", "protein_names_uniprotkb": "Neuropilin and tolloid-like protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2", "protein_names_refseq": "brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; neuropilin (NRP) and tolloid (TLL)-like 2; neuropilin and tolloid-like protein 2 precursor; neuropilin and tolloid-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:307757)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19217376;21593317;28100490;28717010;31628192;37544581", "class_list": "", "function": "Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission., [UniProtKB, PubMed]; Data suggest Camk2a and Prkaca exhibit substrate specificity that includes phosphorylation of Neto2 at Ser409 in C-terminal domain; Neto2 Ser409 phosphorylation inhibits synaptic targeting of Gluk1. (Camk2a = calcium-calmodulin-dependent protein kinase II, alpha subunit; Prkaca = cAMP-dependent protein kinase, alpha-catalytic subunit; Neto2 = neuropilin and tolloid-like protein 2; Gluk1 = kainate receptor Gluk1), [RefSeq, PubMed]; GluK2 surface and synaptic expression are independent on the auxiliary subunits Neto1 and Neto2. In the CA1 hippocampal pyramidal cell, GluK2, in contrast to GluK1, traffics to the neuronal surface and synapse efficiently and the auxiliary subunits rNeto1 and mNeto2 caused no further enhancement of these two trafficking processes., [RefSeq, PubMed]; NETO2 slows the desensitization rate of glutamate K2 kainate (GluK2a) receptors, promotes plasma membrane localization of receptors in hippocampal neurons, and targets GluK1-containing receptors to synapses., [RefSeq, PubMed]; NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn., [RefSeq, PubMed]; Neto1 and Neto2 differentially regulate GluK2 fast gating kinetics, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0098839 postsynaptic density membrane;GO:0016020 membrane", "go_biological_process": "GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "C6K2K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40190-1", "uniprot_id": [ { "id": "IL6RB_RAT", "url": "https://www.uniprot.org/uniprot/P40190", "type": "external" } ], "mass": 102450.0, "length": 918, "protein_name": "Interleukin-6 receptor subunit beta", "gene_name": "Il6st", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il6st", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; Interleukin-6 signal transducer; Membrane glycoprotein 130; Oncostatin-M receptor subunit alpha; gp130", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); autosomal dominant intellectual developmental disorder 62 (Disease Ontology:DOID:0061035); immunodeficiency 94 (Disease Ontology:DOID:0061064); hyper IgE recurrent infection syndrome 4 (Disease Ontology:DOID:0080596); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hyperandrogenism (Disease Ontology:DOID:11613); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); Williams-Beuren syndrome (Disease Ontology:DOID:1928); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); carcinoma (Disease Ontology:DOID:305); temporal lobe epilepsy (Disease Ontology:DOID:3328); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (R-RNO-1059683); (R-RNO-110056); (R-RNO-112411); (R-RNO-6788467); (R-RNO-8984722); (R-RNO-9020956); (R-RNO-9958825)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "1427893;22673903", "class_list": "", "function": "Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1. Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6. Initiates signal transmission through three mechanisms. Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130. In contrast, binding of other IL-6 family cytokines can result in the formation of a IL6ST/gp130 heterodimer with another signal-transducing receptor, such as LIFR or OSMR. Moreover, binding of CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor CNTFR induces heterodimerization of the IL6ST/gp130 with LIFR or IL27RA/WSX1 (in the case of MT-RNR2/humanin). Homodimerization or heterodimerization of IL6ST/gp130 activate JAK tyrosine kinases bound to their intracellular domains. These kinases subsequently phosphorylate the homodimer or heterodimer form of IL6ST/gp130. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (By similarity). The IL6 signaling pathway induces, in parallel, the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0015026 coreceptor activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0030296 protein tyrosine kinase activator activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005896 interleukin-6 receptor complex;GO:0005900 oncostatin-M receptor complex;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038165 oncostatin-M-mediated signaling pathway;GO:0070104 negative regulation of interleukin-6-mediated signaling pathway;GO:0070106 interleukin-27-mediated signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P40190-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18576-1", "uniprot_id": [ { "id": "NFYA_RAT", "url": "https://www.uniprot.org/uniprot/P18576", "type": "external" } ], "mass": 36294.0, "length": 341, "protein_name": "Nuclear transcription factor Y subunit alpha", "gene_name": "Nfya", "organism": "Rat", "refseq_name": "nuclear transcription factor Y subunit alpha isoform 2", "refseq_ac": [ { "id": "NP_036997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036997", "type": "external" } ], "gene_names_uniprotkb": "Nfya", "gene_names_refseq": "CBF-A; CBF-B; Nfya", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; CBF-A; CCAAT-binding transcription factor subunit A; NF-YA; Nuclear transcription factor Y subunit A", "protein_names_refseq": "CAAT box DNA-binding protein subunit A; CCAAT-binding transcription factor subunit A; CCAAT-binding transcription factor subunit B; nuclear transcription factor Y subunit A; nuclear transcription factor Y subunit alpha isoform 2; nuclear transcription factor-Y alpha", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29508)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1569083;2196566;22673903", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18576-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06880-1", "uniprot_id": [ { "id": "NBL1_RAT", "url": "https://www.uniprot.org/uniprot/Q06880", "type": "external" } ], "mass": 19191.0, "length": 178, "protein_name": "Neuroblastoma suppressor of tumorigenicity 1", "gene_name": "Nbl1", "organism": "Rat", "refseq_name": "neuroblastoma suppressor of tumorigenicity 1 precursor", "refseq_ac": [ { "id": "NP_113797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113797", "type": "external" } ], "gene_names_uniprotkb": "Nbl1; Dan", "gene_names_refseq": "Nbl1", "protein_names_uniprotkb": "Neuroblastoma suppressor of tumorigenicity 1; N03; Zinc finger protein DAN", "protein_names_refseq": "N03; Neuroblastoma, suppression of tumorigenicity 1 (DNA segment human D1S1733E); neuroblastoma 1, DAN family BMP antagonist; neuroblastoma suppressor of tumorigenicity 1 precursor; neuroblastoma suppressor of tumorigenicity 1; zinc finger protein DAN", "tax_id": 10116, "disease": "mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (Disease Ontology:DOID:0070540); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:50594)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22357543;7942277;8385338", "class_list": "", "function": "Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process., [UniProtKB, UniProtKB, UniProtKB]; The findings suggested that the NBL1 gradient in granulosa cells, established by oocyte-derived GDF9, may serve as an antagonist barrier that modulates the actions of theca-derived BMP4 and granulosa/theca-derived BMP2 during folliculogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P750", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0048018 receptor ligand activity;GO:0016015 morphogen activity;GO:0036122 BMP binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06880-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AAT7-1", "uniprot_id": [ { "id": "NNRD_RAT", "url": "https://www.uniprot.org/uniprot/D4AAT7", "type": "external" } ], "mass": 36518.0, "length": 343, "protein_name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase", "gene_name": "Naxd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Naxd; CARKD; Carkd", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase; 4.2.1.93; ATP-dependent NAD(P)HX dehydratase; Carbohydrate kinase domain-containing protein; NAD(P)HX dehydratase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-196807)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.93", "type": "external" } ], "go_molecular_function": "GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046496 nicotinamide nucleotide metabolic process;GO:0110051 metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AAT7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55173-1", "uniprot_id": [ { "id": "PDPK1_RAT", "url": "https://www.uniprot.org/uniprot/O55173", "type": "external" } ], "mass": 63593.0, "length": 559, "protein_name": "3-phosphoinositide-dependent protein kinase 1", "gene_name": "Pdpk1", "organism": "Rat", "refseq_name": "3-phosphoinositide-dependent protein kinase 1", "refseq_ac": [ { "id": "NP_112343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112343", "type": "external" } ], "gene_names_uniprotkb": "Pdpk1; Pdk1", "gene_names_refseq": "Pdpk1", "protein_names_uniprotkb": "3-phosphoinositide-dependent protein kinase 1; 2.7.11.1; PkB kinase; Protein kinase B kinase", "protein_names_refseq": "3-phosphoinositide-dependent protein kinase 1; pkB kinase; protein kinase B kinase", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:81745); (R-RNO-114604); (R-RNO-1257604); (R-RNO-165158); (R-RNO-202424); (R-RNO-2730905); (R-RNO-2871837); (R-RNO-354192); (R-RNO-389357); (R-RNO-392451); (R-RNO-5218920); (R-RNO-5218921); (R-RNO-5607764); (R-RNO-5625740); (R-RNO-6804757); (R-RNO-9634635); (R-RNO-9856530)", "pathway_count": 17, "publication_count": 8, "publication_id_list": "11781095;22673903;32373981;33199822;34133802;35061720;37162681;9445477", "class_list": "", "function": "A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro. Erratum:[PLoS One. 2024 May 29;19(5):e0304731. doi: 10.1371/journal.pone.0304731. PMID: 38809827] Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding Mirt2 reduces apoptosis to alleviate myocardial infarction through regulation of the miR-764/PDK1 axis., [RefSeq, PubMed]; M1 and M2 mAChRs activate PDK1 and regulate PKC betaI and epsilon and the exocytotic apparatus at the NMJ., [RefSeq, PubMed]; PDK1 upregulates PINK1-mediated pulmonary endothelial cell mitophagy during hypoxia-induced pulmonary vascular remodeling., [RefSeq, PubMed]; STRAP reduces endoplasmic reticulum stress and apoptosis in cardiomyocytes and attenuates myocardial ischemia-reperfusion injury by activating PI3K/PDK1/Akt signaling pathway., [RefSeq, PubMed]; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (By similarity). Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), TSSK3, protein kinase PKN (PKN1 and PKN2) (PubMed:11781095). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage (By similarity). Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta (By similarity). Activates PPARG transcriptional activity and promotes adipocyte differentiation (By similarity). Activates the NF-kappa-B pathway via phosphorylation of IKKB (By similarity). The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II (By similarity). Controls proliferation, survival, and growth of developing pancreatic cells (By similarity). Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells (By similarity). Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis (By similarity). Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response (By similarity). Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses (By similarity). Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V9W3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016004 phospholipase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O55173-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97636-1", "uniprot_id": [ { "id": "IL18_RAT", "url": "https://www.uniprot.org/uniprot/P97636", "type": "external" } ], "mass": 22303.0, "length": 194, "protein_name": "Interleukin-18", "gene_name": "Il18", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il18; Igif", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-18; IFN-gamma-inducing factor; IL-1 gamma; IL-18; Interferon gamma-inducing factor; Interleukin-1 gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); sleep apnea (Disease Ontology:DOID:0050847); stroke (Disease Ontology:DOID:0051061); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); cardiac arrest (Disease Ontology:DOID:0060319); intrahepatic cholestasis of pregnancy (Disease Ontology:DOID:0070227); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); urinary tract infection (Disease Ontology:DOID:0080784); Graves ophthalmopathy (Disease Ontology:DOID:0081120); dermatomyositis (Disease Ontology:DOID:10223); respiratory failure (Disease Ontology:DOID:11162); sarcoidosis (Disease Ontology:DOID:11335); heart disease (Disease Ontology:DOID:114); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); paracoccidioidomycosis (Disease Ontology:DOID:12662); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Kawasaki disease (Disease Ontology:DOID:13378); pulmonary sarcoidosis (Disease Ontology:DOID:13406); biliary atresia (Disease Ontology:DOID:13608); cystic fibrosis (Disease Ontology:DOID:1485); urticaria (Disease Ontology:DOID:1555); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); hepatitis C (Disease Ontology:DOID:1883); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); atopic dermatitis (Disease Ontology:DOID:3310); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); brain edema (Disease Ontology:DOID:4724); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); steatotic liver disease (Disease Ontology:DOID:9452); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29197); (R-RNO-448706); (R-RNO-5620971); (R-RNO-9012546)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12787406;29393594;8999896;9702748", "class_list": "", "function": "Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 72, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88749;P97637;Q541E6", "ec_number_list": [], "go_molecular_function": "GO:0045515 interleukin-18 receptor binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0140368 decoy receptor complex", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0051142 positive regulation of NK T cell proliferation;GO:2000504 positive regulation of blood vessel remodeling;GO:0032740 positive regulation of interleukin-17 production;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97636-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09216-1", "uniprot_id": [ { "id": "KPCE_RAT", "url": "https://www.uniprot.org/uniprot/P09216", "type": "external" } ], "mass": 83478.0, "length": 737, "protein_name": "Protein kinase C epsilon type", "gene_name": "Prkce", "organism": "Rat", "refseq_name": "protein kinase C epsilon type", "refseq_ac": [ { "id": "NP_058867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058867", "type": "external" } ], "gene_names_uniprotkb": "Prkce; Pkce", "gene_names_refseq": "Pkce; Prkce", "protein_names_uniprotkb": "Protein kinase C epsilon type; 2.7.11.13; nPKC-epsilon", "protein_names_refseq": "nPKC-epsilon; protein kinase C epsilon type", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29340); (R-RNO-114508); (R-RNO-1250196); (R-RNO-1489509); (R-RNO-2029485)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "11278835;11518534;12665800;15596539;17157309;18295358;22673903;24946090;2834397;31473978;32906765;33368632;34147527;35505050;3691811;37906389;9360998", "class_list": "", "function": "Activated Protein Kinase C (PKC) Is Persistently Trafficked with Epidermal Growth Factor (EGF) Receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1. Phosphorylates NLRP5/MATER and may thereby modulate AKT pathway activation in cumulus cells (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury., [RefSeq, PubMed]; PKCepsilon associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner., [RefSeq, PubMed]; PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode., [RefSeq, PubMed]; Roles of Neuronal Protein Kinase Cepsilon on Endoplasmic Reticulum Stress and Autophagic Formation in Diabetic Neuropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0003785 actin monomer binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0006468 protein phosphorylation;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P09216-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PSU6-1", "uniprot_id": [ { "id": "PCX1_RAT", "url": "https://www.uniprot.org/uniprot/E9PSU6", "type": "external" } ], "mass": 257943.0, "length": 2343, "protein_name": "Pecanex-like protein 1", "gene_name": "Pcnx1", "organism": "Rat", "refseq_name": "pecanex-like protein 1", "refseq_ac": [ { "id": "NP_001163818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163818", "type": "external" } ], "gene_names_uniprotkb": "Pcnx1; Pcnx", "gene_names_refseq": "Pcnx1; Pcnx", "protein_names_uniprotkb": "Pecanex-like protein 1; Pecanex 1; Pecanex homolog protein 1", "protein_names_refseq": "pecanex homolog 1; pecanex homolog protein 1; pecanex-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15777640", "class_list": "", "function": "Pecanex 1 could play an important role in the testis, related to spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PSU6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHC1-1", "uniprot_id": [ { "id": "NAA60_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHC1", "type": "external" } ], "mass": 27493.0, "length": 242, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "Cluap1; Naa60", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 60", "refseq_ac": [ { "id": "NP_001014248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014248", "type": "external" } ], "gene_names_uniprotkb": "Cluap1; Naa60; Nat15", "gene_names_refseq": "HAT4; Naa60; Nat15; NatF; RGD1308915", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; HAT4; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF", "protein_names_refseq": "GNAT acetyltransferase; GNAT acetytransferase; N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase 60; N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:363544); (rno:363545)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TMZ6", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005929 cilium", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly;GO:0006474 N-terminal protein amino acid acetylation;GO:0017196 N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3MHC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JU68-1", "uniprot_id": [ { "id": "EIF3A_RAT", "url": "https://www.uniprot.org/uniprot/Q1JU68", "type": "external" } ], "mass": 163196.0, "length": 1354, "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "Eif3a", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit A", "refseq_ac": [ { "id": "NP_001040552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040552", "type": "external" } ], "gene_names_uniprotkb": "Eif3a; EIF3A; EIF3S10; Eif3s10", "gene_names_refseq": "Eif3a; Eif3s10; ZH12", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit A; Eukaryotic translation initiation factor 3 subunit 10; eIF-3-theta; eIF3a", "protein_names_refseq": "eIF-3-theta; eukaryotic translation initiation factor 3 subunit 10; eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta)", "tax_id": 10116, "disease": "", "pathway": " (rno:292148); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "26612348;27453280;28322466;29393594;36921705", "class_list": "", "function": "MiR-497 could suppress TGFbeta1-induced pulmonary fibroblast proliferation and EIF3A, Collagen I and alpha-SMA protein levels., [RefSeq, PubMed]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo., [RefSeq, PubMed]; Silencing eIF3a might alleviate TGF-beta1-induced cardiac fibrogenesis in cardiac fibroblasts by inhibiting Smad3 activation. Publication Status: Online-Only, [RefSeq, PubMed]; The eIF3a plays a crucial role in hypoxia-induced right ventricular remodeling by regulating TGF-beta1-induced proliferation and differentiation of cardiac fibroblasts, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030971 receptor tyrosine kinase binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0014069 postsynaptic density;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0002188 translation reinitiation;GO:0075522 IRES-dependent viral translational initiation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q1JU68-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35778-1", "uniprot_id": [ { "id": "KLRD1_RAT", "url": "https://www.uniprot.org/uniprot/O35778", "type": "external" } ], "mass": 20781.0, "length": 179, "protein_name": "Natural killer cells antigen CD94", "gene_name": "Klrd1", "organism": "Rat", "refseq_name": "natural killer cells antigen CD94", "refseq_ac": [ { "id": "NP_036877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036877", "type": "external" } ], "gene_names_uniprotkb": "Klrd1; Cd94", "gene_names_refseq": "Cd94; Klrd1", "protein_names_uniprotkb": "Natural killer cells antigen CD94; Killer cell lectin-like receptor subfamily D member 1", "protein_names_refseq": "CD94 antigen (located within the rat natural killer gene complex); killer cell lectin-like receptor, subfamily D, member 1; natural killer cells antigen CD94", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); Tatton-Brown-Rahman syndrome (Disease Ontology:DOID:0112339); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung carcinoma (Disease Ontology:DOID:3905); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25110); (R-RNO-2172127); (R-RNO-2424491)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22084441;9295048", "class_list": "", "function": "Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule MHC-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal., [UniProtKB, UniProtKB]; KLRD1-KLRC1 acts as an immune inhibitory receptor. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions. Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity. On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens. In MHC-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-peptide binding, transmits intracellular signals through KLRC1 immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules., [UniProtKB, UniProtKB]; KLRD1-KLRC2 acts as an immune activating receptor. On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation., [UniProtKB, UniProtKB]; Rat CD94 coimmunoprecipitates with both DAP12 and DAP10 adaptor proteins., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0030246 carbohydrate binding;GO:1990405 protein antigen binding;GO:0030108 HLA-A specific activating MHC class I receptor activity;GO:0023030 MHC class Ib protein binding, via antigen binding groove", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0002250 adaptive immune response;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0001915 negative regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35778-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04667-1", "uniprot_id": [ { "id": "HES3_RAT", "url": "https://www.uniprot.org/uniprot/Q04667", "type": "external" } ], "mass": 19137.0, "length": 175, "protein_name": "Transcription factor HES-3", "gene_name": "Hes3", "organism": "Rat", "refseq_name": "transcription factor HES-3", "refseq_ac": [ { "id": "NP_073178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073178", "type": "external" } ], "gene_names_uniprotkb": "Hes3; Hes-3", "gene_names_refseq": "Hes3", "protein_names_uniprotkb": "Transcription factor HES-3; Hairy and enhancer of split 3", "protein_names_refseq": "hairy and enhancer of split 3; transcription factor HES-3", "tax_id": 10116, "disease": "", "pathway": " (rno:64628)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1340473", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021555 midbrain-hindbrain boundary morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q04667-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88867-1", "uniprot_id": [ { "id": "KMO_RAT", "url": "https://www.uniprot.org/uniprot/O88867", "type": "external" } ], "mass": 54353.0, "length": 478, "protein_name": "Kynurenine 3-monooxygenase", "gene_name": "Kmo", "organism": "Rat", "refseq_name": "kynurenine 3-monooxygenase", "refseq_ac": [ { "id": "NP_067604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067604", "type": "external" } ], "gene_names_uniprotkb": "Kmo; KMO", "gene_names_refseq": "Kmo", "protein_names_uniprotkb": "Kynurenine 3-monooxygenase; 1.14.13.9; Kynurenine 3-hydroxylase", "protein_names_refseq": "kynurenine 3-hydroxylase; kynurenine 3-monooxygenase", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596); schizophrenia (Disease Ontology:DOID:5419); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:59113); (R-RNO-71240)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12402501;1332540;26752518;28398044;29393594", "class_list": "", "function": "Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.9", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0004502 kynurenine 3-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0097052 L-kynurenine metabolic process;GO:0006569 L-tryptophan catabolic process;GO:0032496 response to lipopolysaccharide;GO:0070189 kynurenine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88867-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08388-1", "uniprot_id": [ { "id": "PEMT_RAT", "url": "https://www.uniprot.org/uniprot/Q08388", "type": "external" } ], "mass": 22486.0, "length": 199, "protein_name": "Phosphatidylethanolamine N-methyltransferase", "gene_name": "Pemt", "organism": "Rat", "refseq_name": "phosphatidylethanolamine N-methyltransferase", "refseq_ac": [ { "id": "NP_037135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037135", "type": "external" } ], "gene_names_uniprotkb": "Pemt; PEMT; Pempt", "gene_names_refseq": "PHOMETH; PLMT; Pempt; Pemt", "protein_names_uniprotkb": "Phosphatidylethanolamine N-methyltransferase; 2.1.1.17; 2.1.1.71; PE N-methyltransferase; PEAMT; PEMT; PLMT; Phospholipid methyltransferase", "protein_names_refseq": "PE N-methyltransferase; PEAMT; phosphatidylethanolamine N-methyltransferase; phospholipid methyltransferase", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591)", "pathway": " (rno:25511); (R-RNO-1483191)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "3182818;3680298;8344945", "class_list": "", "function": "Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable) (PubMed:8344945). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (Probable) (PubMed:8344945)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK89", "ec_number_list": [ { "id": "2.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.17", "type": "external" }, { "id": "2.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.71", "type": "external" } ], "go_molecular_function": "GO:0008429 phosphatidylethanolamine binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity;GO:0004608 phosphatidylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042383 sarcolemma;GO:0031526 brush border membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0033273 response to vitamin;GO:0006686 sphingomyelin biosynthetic process;GO:0050747 positive regulation of lipoprotein metabolic process;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08388-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBE5-1", "uniprot_id": [ { "id": "NEK7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBE5", "type": "external" } ], "mass": 34529.0, "length": 302, "protein_name": "Serine/threonine-protein kinase Nek7", "gene_name": "Nek7", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Nek7", "refseq_ac": [ { "id": "NP_001101816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101816", "type": "external" } ], "gene_names_uniprotkb": "Nek7", "gene_names_refseq": "Nek7", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek7; 2.7.11.34; Never in mitosis A-related kinase 7; NimA-related protein kinase 7", "protein_names_refseq": "NIMA (never in mitosis gene a)-related expressed kinase 7; NIMA (never in mitosis gene a)-related kinase 7; never in mitosis A-related kinase 7; nimA-related protein kinase 7; serine/threonine-protein kinase Nek7", "tax_id": 10116, "disease": "", "pathway": " (rno:360850)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11516946;34414459", "class_list": "", "function": "Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1 (PubMed:11516946). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (By similarity). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (By similarity). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Reactive oxygen species induced by uric acid promote NRK52E cell apoptosis through the NEK7NLRP3 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007346 regulation of mitotic cell cycle;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0035865 cellular response to potassium ion;GO:0032206 positive regulation of telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZBE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZT86-1", "uniprot_id": [ { "id": "NET5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZT86", "type": "external" } ], "mass": 49030.0, "length": 456, "protein_name": "Netrin-5", "gene_name": "Ntn5", "organism": "Rat", "refseq_name": "netrin-5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001166997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166997", "type": "external" } ], "gene_names_uniprotkb": "Ntn5", "gene_names_refseq": "Ntn5; RGD1565197", "protein_names_uniprotkb": "Netrin-5; Netrin-1-like protein", "protein_names_refseq": "netrin-1-like protein; netrin-5 isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:308587)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25941474", "class_list": "", "function": "Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005604 basement membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0009887 animal organ morphogenesis;GO:0022008 neurogenesis;GO:0009888 tissue development;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZT86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8P0-1", "uniprot_id": [ { "id": "PARL_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8P0", "type": "external" } ], "mass": 42126.0, "length": 377, "protein_name": "Presenilin-associated rhomboid-like protein, mitochondrial", "gene_name": "Parl", "organism": "Rat", "refseq_name": "presenilin-associated rhomboid-like protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001030326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030326", "type": "external" } ], "gene_names_uniprotkb": "Parl; Psarl", "gene_names_refseq": "Parl; Psarl", "protein_names_uniprotkb": "Presenilin-associated rhomboid-like protein, mitochondrial; 3.4.21.105; Mitochondrial intramembrane-cleaving protease PARL", "protein_names_refseq": "mitochondrial intramembrane-cleaving protease PARL; presenilin-associated rhomboid-like protein, mitochondrial precursor; presenilin-associated rhomboid-like protein, mitochondrial; presenilins-associated rhomboid-like protein, mitochondrial", "tax_id": 10116, "disease": "myopia (Disease Ontology:DOID:11830); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:287979); (R-RNO-8949664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential. Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss. Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide. Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (By similarity). Mediates STARD7 processing which regulates STARD7 location between mitochodria and cytosol. Also required for cleavage of TTC19. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0L2", "ec_number_list": [ { "id": "3.4.21.105", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.105", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0031667 response to nutrient levels;GO:0030162 regulation of proteolysis;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B8P0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88801-1", "uniprot_id": [ { "id": "HOME2_RAT", "url": "https://www.uniprot.org/uniprot/O88801", "type": "external" } ], "mass": 40563.0, "length": 354, "protein_name": "Homer protein homolog 2", "gene_name": "Homer2", "organism": "Rat", "refseq_name": "homer protein homolog 2", "refseq_ac": [ { "id": "NP_445761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445761", "type": "external" } ], "gene_names_uniprotkb": "Homer2; Vesl2", "gene_names_refseq": "Homer2; Vesl-2", "protein_names_uniprotkb": "Homer protein homolog 2; Cupidin; Homer-2; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2", "protein_names_refseq": "VASP/Ena-related gene up-regulated during seizure and LTP 2; cupidin; homer homolog 2; homer protein homolog 2; homer scaffolding protein 2; homer, neuronal immediate early gene, 2; homer-2", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 68 (Disease Ontology:DOID:0110589); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328); muscular atrophy (Disease Ontology:DOID:767); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29547); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14528310;17584991;26254965;9727012", "class_list": "", "function": "In alcohol-preferring rats, Homer2b expression in the nucleus accumbens regulates alcohol consumption., [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88802", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0032703 negative regulation of interleukin-2 production;GO:0019722 calcium-mediated signaling;GO:0045471 response to ethanol;GO:0042220 response to cocaine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88801-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27881-1", "uniprot_id": [ { "id": "HXK2_RAT", "url": "https://www.uniprot.org/uniprot/P27881", "type": "external" } ], "mass": 102544.0, "length": 917, "protein_name": "Hexokinase-2", "gene_name": "Hk2", "organism": "Rat", "refseq_name": "hexokinase-2", "refseq_ac": [ { "id": "NP_036867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036867", "type": "external" } ], "gene_names_uniprotkb": "Hk2", "gene_names_refseq": "Hk2", "protein_names_uniprotkb": "Hexokinase-2; 2.7.1.1; HK II; Hexokinase type II; Hexokinase-B", "protein_names_refseq": "HK II; hexokinase type II; hexokinase-2; hexokinase-B; type II hexokinase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25059); (R-RNO-70171)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1897984;23836898;32415544;32495363;32579577;37715611;38531963;5871820;7044667;7622509;7873617", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis., [RefSeq, PubMed]; Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy., [RefSeq, PubMed]; LncRNA-XIST protects the hypoxia-induced cardiomyocyte injury through regulating the miR-125b-hexokianse 2 axis., [RefSeq, PubMed]; Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWR1", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0005524 ATP binding;GO:0004396 hexokinase activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0035795 negative regulation of mitochondrial membrane permeability;GO:0002931 response to ischemia;GO:0001666 response to hypoxia;GO:0045766 positive regulation of angiogenesis;GO:0046324 regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P27881-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54937-1", "uniprot_id": [ { "id": "PDK4_RAT", "url": "https://www.uniprot.org/uniprot/O54937", "type": "external" } ], "mass": 46679.0, "length": 412, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial", "gene_name": "Pdk4", "organism": "Rat", "refseq_name": "pyruvate dehydrogenase kinase, isozyme 4", "refseq_ac": [ { "id": "NP_446003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446003", "type": "external" } ], "gene_names_uniprotkb": "Pdk4", "gene_names_refseq": "Pdk4", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; 2.7.11.2; Pyruvate dehydrogenase kinase isoform 4", "protein_names_refseq": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenate kinase 4", "tax_id": 10116, "disease": "", "pathway": " (rno:89813); (R-RNO-204174); (R-RNO-5362517)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11486000;19703515;19948729;20739620;33203874;34517782;36281857;38401019;9405293", "class_list": "", "function": "Inhibition of Pyruvate Dehydrogenase Kinase 4 Protects Cardiomyocytes from lipopolysaccharide-Induced Mitochondrial Damage by Reducing Lactate Accumulation., [RefSeq, PubMed]; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism., [UniProtKB, PubMed]; MicroRNA -148 alleviates cardiac dysfunction, immune disorders and myocardial apoptosis in myocardial ischemia-reperfusion (MI/R) injury by targeting pyruvate dehydrogenase kinase (PDK4)., [RefSeq, PubMed]; PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming. Publication Status: Online-Only, [RefSeq, PubMed]; Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0010565 regulation of ketone metabolic process;GO:0006468 protein phosphorylation;GO:0042594 response to starvation;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54937-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59895-1", "uniprot_id": [ { "id": "NEK6_RAT", "url": "https://www.uniprot.org/uniprot/P59895", "type": "external" } ], "mass": 35835.0, "length": 313, "protein_name": "Serine/threonine-protein kinase Nek6", "gene_name": "Nek6", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Nek6", "refseq_ac": [ { "id": "NP_001264161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264161", "type": "external" } ], "gene_names_uniprotkb": "Nek6", "gene_names_refseq": "Nek6", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek6; 2.7.11.34; Never in mitosis A-related kinase 6; NimA-related protein kinase 6", "protein_names_refseq": "NIMA (never in mitosis gene a)-related expressed kinase 6; never in mitosis A-related kinase 6; nimA-related protein kinase 6; serine/threonine-protein kinase Nek6", "tax_id": 10116, "disease": "", "pathway": " (rno:360161)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11516946", "class_list": "", "function": "Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIRSR, PTN, RAD26L, RBBP6, RPS7, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity). Phosphorylates RPS6KB1 (PubMed:11516946). Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007059 chromosome segregation;GO:0007165 signal transduction;GO:0051301 cell division;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59895-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07808-1", "uniprot_id": [ { "id": "NPY_RAT", "url": "https://www.uniprot.org/uniprot/P07808", "type": "external" } ], "mass": 11033.0, "length": 98, "protein_name": "Pro-neuropeptide Y", "gene_name": "Npy", "organism": "Rat", "refseq_name": "pro-neuropeptide Y preproprotein", "refseq_ac": [ { "id": "NP_036746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036746", "type": "external" } ], "gene_names_uniprotkb": "Npy", "gene_names_refseq": "NPY02; Npy; RATNPY02; RATNPY", "protein_names_uniprotkb": "Pro-neuropeptide Y; NPY; Neuropeptide tyrosine", "protein_names_refseq": "pro-neuropeptide Y preproprotein; pro-neuropeptide Y-like; pro-neuropeptide Y", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); peripheral artery disease (Disease Ontology:DOID:0050830); absence epilepsy (Disease Ontology:DOID:0070309); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); anxiety disorder (Disease Ontology:DOID:2030); arteriosclerosis (Disease Ontology:DOID:2349); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); median neuropathy (Disease Ontology:DOID:571); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24604); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "22406386;25109664;2560178;2834371;29166604;29393594;30021165;3031663;3031687;3413293;34666848;35008014;35313782;36565980;37653540;6549409", "class_list": "", "function": "Adolescent binge-like alcohol exposure dysregulates NPY and CGRP in rats: Behavioural and immunochemical evidence., [RefSeq, PubMed]; Identification of a novel rat neuropeptide Y mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model., [RefSeq, PubMed]; Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behaviour, acting as a stimulator of food intake (PubMed:25109664, PubMed:2560178, PubMed:6549409). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone., [UniProtKB, UniProtKB]; Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects. Publication Status: Online-Only, [RefSeq, PubMed]; Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis., [RefSeq, PubMed]; Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours., [RefSeq, PubMed]; Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression., [RefSeq, PubMed]; This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Studies in the rat model of depression (Flinders Sensitive Line) show that this gene is downregulated in the hippocampus and the prefrontal cortex compared to the control ((Flinders Resistant Line). Alternatively spliced transcript variants of this gene have been described, but the function of all the variants is not known. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding;GO:0160041 neuropeptide activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0032100 positive regulation of appetite;GO:1904000 positive regulation of eating behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07808-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84817-1", "uniprot_id": [ { "id": "FIS1_RAT", "url": "https://www.uniprot.org/uniprot/P84817", "type": "external" } ], "mass": 16995.0, "length": 152, "protein_name": "Mitochondrial fission 1 protein", "gene_name": "Fis1", "organism": "Rat", "refseq_name": "mitochondrial fission 1 protein isoform 1", "refseq_ac": [ { "id": "NP_001099389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099389", "type": "external" } ], "gene_names_uniprotkb": "Fis1; Ttc11", "gene_names_refseq": "Fis1; Ttc11", "protein_names_uniprotkb": "Mitochondrial fission 1 protein; FIS1 homolog; TPR repeat protein 11; Tetratricopeptide repeat protein 11; rFis1", "protein_names_refseq": "TPR repeat protein 11; fis1 homolog; fission 1 (mitochondrial outer membrane) homolog; mitochondrial fission 1 protein isoform 1; mitochondrial fission 1 protein; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dental fluorosis (Disease Ontology:DOID:13711); acute kidney failure (Disease Ontology:DOID:3021); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:288584); (R-RNO-9603798)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15979461;28100784;28265681", "class_list": "", "function": "Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:15979461). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event. Also mediates peroxisomal fission. May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis., [UniProtKB, UniProtKB]; Right ventricular ischemia occurs in pulmonary arterial hypertension and causes Drp1-Fis1-mediated fission leading to diastolic dysfunction., [RefSeq, PubMed]; These experiments revealed that the N-terminal and C-terminal segments are both essential for oligomeric rFis1 interaction, and the middle TPR-like domains regulate proper oligomer assembly., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RZ80;D4A5K3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1905395 response to flavonoid;GO:1990910 response to hypobaric hypoxia;GO:0016559 peroxisome fission;GO:0071333 cellular response to glucose stimulus;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P84817-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15791-1", "uniprot_id": [ { "id": "KCC2D_RAT", "url": "https://www.uniprot.org/uniprot/P15791", "type": "external" } ], "mass": 60081.0, "length": 533, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit delta", "gene_name": "Camk2d", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1", "refseq_ac": [ { "id": "NP_036651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036651", "type": "external" } ], "gene_names_uniprotkb": "Camk2d", "gene_names_refseq": "CAMK1; Camk2d; Camk2; Camki; RATCAMKI", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit delta; 2.7.11.17; CaM kinase II subunit delta; CaMK-II subunit delta", "protein_names_refseq": "Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; caM kinase II subunit delta; caM-kinase II delta chain; caMK-II subunit delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1; calcium/calmodulin-dependent protein kinase type II subunit delta", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 6 (Disease Ontology:DOID:0080358); heart conduction disease (Disease Ontology:DOID:10273); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); ovarian dysfunction (Disease Ontology:DOID:1414); renovascular hypertension (Disease Ontology:DOID:1591); epilepsy (Disease Ontology:DOID:1826); Leigh disease (Disease Ontology:DOID:3652); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24246); (R-RNO-3371571); (R-RNO-399719); (R-RNO-438066); (R-RNO-5578775); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-877300); (R-RNO-936837)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10825152;16891908;17923476;18056528;22673903;2553697;31584202;32971072;33281190;34814703;35138512;38843836;8224201;8390994", "class_list": "", "function": "AKAP18delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR., [RefSeq, PubMed]; CaMKII exacerbates heart failure progression by activating class I HDACs., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:17923476). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17923476). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:10825152). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Consumption of combined fructose and sucrose diet exacerbates oxidative stress, hypertrophy and CaMKIIdelta oxidation in hearts from rats with metabolic syndrome., [RefSeq, PubMed]; Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-delta in sepsis-associated liver injury. Publication Status: Online-Only, [RefSeq, PubMed]; The combined inhibition of the CaMKIIdelta and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97915;P97916;Q3B7L0;Q63904;Q63905;Q63906;Q63907;Q63908", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0086003 cardiac muscle cell contraction;GO:1901897 regulation of relaxation of cardiac muscle;GO:0006468 protein phosphorylation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P15791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63090-1", "uniprot_id": [ { "id": "PTN_RAT", "url": "https://www.uniprot.org/uniprot/P63090", "type": "external" } ], "mass": 18869.0, "length": 168, "protein_name": "Pleiotrophin", "gene_name": "Ptn", "organism": "Rat", "refseq_name": "pleiotrophin precursor", "refseq_ac": [ { "id": "NP_058762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058762", "type": "external" } ], "gene_names_uniprotkb": "Ptn", "gene_names_refseq": "HARP; Hbnf; Ptn", "protein_names_uniprotkb": "Pleiotrophin; HB-GAM; HBBM; HBGF-8; HBNF; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; PTN", "protein_names_refseq": "HB-GAM; HBBM; HBGF-8; OSF-1; Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); heparin affine regulatory peptide; heparin binding factor; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurotrophic factor; heparin-binding neutrophic factor; osteoblast-specific factor 1; pleiotrophin precursor", "tax_id": 10116, "disease": "craniosynostosis 4 (Disease Ontology:DOID:0061012); sciatic neuropathy (Disease Ontology:DOID:11446); extrahepatic cholestasis (Disease Ontology:DOID:13619); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); adrenal carcinoma (Disease Ontology:DOID:3950); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24924); (R-RNO-201556); (R-RNO-9851151)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10413105;16814777;1700712;1768439;2170351;2270483;2388713;27671118;8175719;9817766", "class_list": "", "function": "Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16814777, PubMed:27671118, PubMed:9817766). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:27671118, PubMed:9817766). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:16814777). Through PTPRZ1 binding, regulates endothelial cell migration and controls oligodendrocyte precursor cell differentiation (By similarity). Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (PubMed:27671118). Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (PubMed:9817766). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (By similarity). Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (By similarity). In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20935", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:1904399 heparan sulfate binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0048680 positive regulation of axon regeneration;GO:1990089 response to nerve growth factor;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10739-1", "uniprot_id": [ { "id": "MMP14_RAT", "url": "https://www.uniprot.org/uniprot/Q10739", "type": "external" } ], "mass": 66080.0, "length": 582, "protein_name": "Matrix metalloproteinase-14", "gene_name": "Mmp14", "organism": "Rat", "refseq_name": "matrix metalloproteinase-14 precursor", "refseq_ac": [ { "id": "NP_112318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112318", "type": "external" } ], "gene_names_uniprotkb": "Mmp14; Mtmmp", "gene_names_refseq": "Mmp14; Mt1-mmp", "protein_names_uniprotkb": "Matrix metalloproteinase-14; 3.4.24.80; MMP-14; MT-MMP 1; MT-MMP; MT1-MMP; MT1MMP; MTMMP1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "MMP-14; MT-MMP 1; MT1MMP; MTMMP1; matrix metallopeptidase 14 (membrane-inserted); matrix metalloproteinase 14 membrane-inserted; matrix metalloproteinase-14 precursor; matrix metalloproteinase-14; membrane type 1-matrix metalloproteinase; membrane-type matrix metalloproteinase 1", "tax_id": 10116, "disease": "Winchester syndrome (Disease Ontology:DOID:0080696); intracranial aneurysm (Disease Ontology:DOID:10941); diabetic angiopathy (Disease Ontology:DOID:11713); dilated cardiomyopathy (Disease Ontology:DOID:12930); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); transitional cell carcinoma (Disease Ontology:DOID:2671); IgA glomerulonephritis (Disease Ontology:DOID:2986); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (rno:81707); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-9839383)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "21454685;29853773;30035384;30659604;33287916;34229297;7708715", "class_list": "", "function": "Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis., [RefSeq, PubMed]; Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-kappaB signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Endopeptidase that degrades various components of the extracellular matrix such as collagen (By similarity). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL., [UniProtKB, UniProtKB, UniProtKB]; Evidence shows that MT1-MMP take action in the beginning of vascular matrix dissolution, endothelial cell growth, vascular remodeling and ultimately in angiogenesis., [RefSeq, PubMed]; Our results suggest that mechanical stretching inhibits bone-marrow-derived mesenchymal stem cells invasion by downregulating MT1-MMP expression by suppressing the PI3K/Akt signaling pathway., [RefSeq, PubMed]; The results suggest that MMP-14 is involved in proliferative diabetic retinopathy angiogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN06", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.80", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0097094 craniofacial suture morphogenesis;GO:1905523 positive regulation of macrophage migration;GO:0071412 cellular response to genistein;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q10739-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17425-1", "uniprot_id": [ { "id": "HMCS1_RAT", "url": "https://www.uniprot.org/uniprot/P17425", "type": "external" } ], "mass": 57434.0, "length": 520, "protein_name": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic", "gene_name": "Hmgcs1", "organism": "Rat", "refseq_name": "hydroxymethylglutaryl-CoA synthase, cytoplasmic", "refseq_ac": [ { "id": "NP_058964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058964", "type": "external" } ], "gene_names_uniprotkb": "Hmgcs1; Hmgcs", "gene_names_refseq": "Hmgcs1", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 1; hydroxymethylglutaryl-CoA synthase, cytoplasmic", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29637); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18683930;1972979;27671501", "class_list": "", "function": "Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis., [UniProtKB, UniProtKB]; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA., [UniProtKB, UniProtKB, UniProtKB]; Results identify 3-hydroxy-3-methylglutaryl coenzyme A synthase isoenzymes 1 and 2 as the alternative markers for satellite glial cells (SGCs) in dorsal root ganglia (DRGs). Downregulated HMGCS1 expression in DRGs after spinal nerve injury may reflect a potential role of abnormal sterol metabolism of SGCs in the nerve injured-induced neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" } ], "go_molecular_function": "GO:0043177 organic acid binding;GO:0042803 protein homodimerization activity;GO:0036094 small molecule binding;GO:0016853 isomerase activity;GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0009645 response to low light intensity stimulus;GO:0046690 response to tellurium ion;GO:0001889 liver development;GO:0014074 response to purine-containing compound;GO:0071397 cellular response to cholesterol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P17425-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PU28-1", "uniprot_id": [ { "id": "IMDH2_RAT", "url": "https://www.uniprot.org/uniprot/E9PU28", "type": "external" } ], "mass": 55815.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 2", "gene_name": "Impdh2", "organism": "Rat", "refseq_name": "inosine-5'-monophosphate dehydrogenase 2", "refseq_ac": [ { "id": "NP_954530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954530", "type": "external" } ], "gene_names_uniprotkb": "Impdh2; IMPDH", "gene_names_refseq": "IMPD 2; IMPDH 2; Impdh2", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 2; 1.1.1.205; IMP dehydrogenase 2; IMPD 2; IMPDH 2", "protein_names_refseq": "IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:301005); (R-RNO-6798695); (R-RNO-73817); (R-RNO-9748787)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003938 IMP dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0007623 circadian rhythm;GO:0071353 cellular response to interleukin-4;GO:0046651 lymphocyte proliferation;GO:0006177 GMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E9PU28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41135-1", "uniprot_id": [ { "id": "ID1_RAT", "url": "https://www.uniprot.org/uniprot/P41135", "type": "external" } ], "mass": 17397.0, "length": 164, "protein_name": "DNA-binding protein inhibitor ID-1", "gene_name": "Id1", "organism": "Rat", "refseq_name": "DNA-binding protein inhibitor ID-1", "refseq_ac": [ { "id": "NP_036929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036929", "type": "external" } ], "gene_names_uniprotkb": "Id1; Id-1", "gene_names_refseq": "ID125A; Id1; Idb1", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-1; Inhibitor of DNA binding 1; Inhibitor of differentiation 1", "protein_names_refseq": "DNA-binding protein inhibitor ID-1; Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation); Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation); inhibitor of DNA binding 1, HLH protein; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; inhibitor of differentiation 1", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 (Disease Ontology:DOID:0111516); portal hypertension (Disease Ontology:DOID:10762); cholestasis (Disease Ontology:DOID:13580); primary pulmonary hypertension (Disease Ontology:DOID:14557); glaucoma (Disease Ontology:DOID:1686); pulmonary hypertension (Disease Ontology:DOID:6432); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:25261); (R-RNO-2559585)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1378442;27127787;29721855;7864897;7908517;8106493", "class_list": "", "function": "These results revealed the critical roles of Id1 and SHH mediating Abeta-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons., [RefSeq, PubMed]; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity)., [UniProtKB]; Via RNAi, it was found that ID1 induction was inhibited with silencing of HIF-1alpha. Moreover, the suppression of ID1 mRNA expression could lead to decreased expression and transcription of HIF-1alpha during hypoxia and reoxygenation. In addition, it was demonstrated that both ID1 and HIF-1alpha can regulate the transcription of twist, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0070628 proteasome binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0036164 cell-abiotic substrate adhesion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41135-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8Q2-1", "uniprot_id": [ { "id": "IF4A3_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8Q2", "type": "external" } ], "mass": 46841.0, "length": 411, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "Eif4a3", "organism": "Rat", "refseq_name": "eukaryotic initiation factor 4A-III", "refseq_ac": [ { "id": "NP_001093628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093628", "type": "external" } ], "gene_names_uniprotkb": "Eif4a3; Ddx48", "gene_names_refseq": "Eif4a3; eIF4A-III", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3; eIF-4A-III; eIF4A-III", "protein_names_refseq": "ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; eIF-4A-III; eukaryotic initiation factor 4A-III", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:688288); (R-RNO-159236); (R-RNO-429947); (R-RNO-72163); (R-RNO-975957)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "17632064;22982623;37839527", "class_list": "", "function": "ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development., [UniProtKB, UniProtKB]; EIF4A3-mediated circEHMT1 regulation in retinal microvascular endothelial dysfunction in diabetic retinopathy., [RefSeq, PubMed]; These findings thus further implicate eIF4A3 as a key mediator of Arc protein mRNA availability underlying learning and memory processes in vivo, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0043021 ribonucleoprotein complex binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0016071 mRNA metabolic process;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0072715 cellular response to selenite ion;GO:1904570 negative regulation of selenocysteine incorporation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3B8Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31503-1", "uniprot_id": [ { "id": "PO2F1_RAT", "url": "https://www.uniprot.org/uniprot/P31503", "type": "external" } ], "mass": 65170.0, "length": 632, "protein_name": "POU domain, class 2, transcription factor 1", "gene_name": "Pou2f1", "organism": "Rat", "refseq_name": "POU domain, class 2, transcription factor 1", "refseq_ac": [ { "id": "NP_001094109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094109", "type": "external" } ], "gene_names_uniprotkb": "Pou2f1; Oct-1; Otf-1; Otf1", "gene_names_refseq": "Pou2f1", "protein_names_uniprotkb": "POU domain, class 2, transcription factor 1; NF-A1; OTF-1; Oct-1; Octamer-binding protein 1; Octamer-binding transcription factor 1", "protein_names_refseq": "NF-A1; OTF-1; POU domain, class 2, transcription factor 1; oct-1; octamer-binding protein 1; octamer-binding transcription factor 1", "tax_id": 10116, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": " (rno:171068); (R-RNO-6807505); (R-RNO-76071); (R-RNO-9018519)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1677182;19617623;22673903;37592110;8424955", "class_list": "", "function": "Data show that cAMP elevation reduces nuclear Oct-1 content in primary pancreatic islet cells., [RefSeq, PubMed]; POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment., [RefSeq, PubMed]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62719;Q63387", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0097421 liver regeneration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P31503-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35233-1", "uniprot_id": [ { "id": "PTN2_RAT", "url": "https://www.uniprot.org/uniprot/P35233", "type": "external" } ], "mass": 48446.0, "length": 416, "protein_name": "Tyrosine-protein phosphatase non-receptor type 2", "gene_name": "Ptpn2", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 2 isoform 1", "refseq_ac": [ { "id": "NP_446442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446442", "type": "external" } ], "gene_names_uniprotkb": "Ptpn2", "gene_names_refseq": "Ptpn2", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 2; 3.1.3.48; Protein-tyrosine phosphatase PTP-S", "protein_names_refseq": "protein-tyrosine phosphatase PTP-S; tyrosine-protein phosphatase non-receptor type 2 isoform 1; tyrosine-protein phosphatase non-receptor type 2", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); pre-eclampsia (Disease Ontology:DOID:10591)", "pathway": " (rno:117063); (R-RNO-6807004); (R-RNO-877312); (R-RNO-9833482)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "1849097;24849651;32054021;35153255;8443161;8534367;8900155", "class_list": "", "function": "Human umbilical cord mesenchymal stem cells alleviate the imbalance of CD4(+) T cells via protein tyrosine phosphatase non-receptor type 2/signal transducer and activator of transcription 3 signaling in ameliorating experimental autoimmune thyroiditis in rats., [RefSeq, PubMed]; Interacts with connexin43 modulating gap junctions, [RefSeq, PubMed]; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA (By similarity)., [UniProtKB, UniProtKB]; Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0003677 DNA binding;GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0070104 negative regulation of interleukin-6-mediated signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0010888 negative regulation of lipid storage;GO:0050922 negative regulation of chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35233-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18422-1", "uniprot_id": [ { "id": "PSA3_RAT", "url": "https://www.uniprot.org/uniprot/P18422", "type": "external" } ], "mass": 28419.0, "length": 255, "protein_name": "Proteasome subunit alpha type-3", "gene_name": "Psma3", "organism": "Rat", "refseq_name": "proteasome subunit alpha type-3", "refseq_ac": [ { "id": "NP_058976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058976", "type": "external" } ], "gene_names_uniprotkb": "Psma3", "gene_names_refseq": "Psma3l; Psma3", "protein_names_uniprotkb": "Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; Proteasome subunit K; Proteasome subunit alpha-7; alpha-7", "protein_names_refseq": "alpha-7; macropain subunit C8; multicatalytic endopeptidase complex subunit C8; multicatalytic proteinase subunit K; proteasome (prosome, macropain) subunit, alpha type 3; proteasome component C8; proteasome subunit C8; proteasome subunit K; proteasome subunit alpha 3; proteasome subunit alpha type-3; proteasome subunit alpha-7", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:29670); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 5, "publication_id_list": "16641100;2249692;22673903;2335242;2403356", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18422-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23266-1", "uniprot_id": [ { "id": "O1361_RAT", "url": "https://www.uniprot.org/uniprot/P23266", "type": "external" } ], "mass": 34703.0, "length": 313, "protein_name": "Olfactory receptor 1f45", "gene_name": "Or1f20e; Or1f32; Or1f45", "organism": "Rat", "refseq_name": "olfactory receptor 1f45", "refseq_ac": [ { "id": "NP_775455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775455", "type": "external" } ], "gene_names_uniprotkb": "Or1f20e; Or1f32; Or1f45; Olr1366; Or1f20e; Or1f28; Or1f29l1; Or1f32", "gene_names_refseq": "Olr1361; Or1f45", "protein_names_uniprotkb": "Olfactory receptor 1f45; Olfactory receptor 1361; Olfactory receptor-like protein F5", "protein_names_refseq": "olfactory protein; olfactory receptor 1361; olfactory receptor 1f45; olfactory receptor-like protein F5", "tax_id": 10116, "disease": "", "pathway": " (rno:287000); (rno:287082); (rno:287093); (rno:363546)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23266-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35878-1", "uniprot_id": [ { "id": "HSPB2_RAT", "url": "https://www.uniprot.org/uniprot/O35878", "type": "external" } ], "mass": 20347.0, "length": 182, "protein_name": "Heat shock protein beta-2", "gene_name": "C8h11orf52; Hspb2", "organism": "Rat", "refseq_name": "heat shock protein beta-2 isoform 1", "refseq_ac": [ { "id": "NP_569115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569115", "type": "external" } ], "gene_names_uniprotkb": "C8h11orf52; Hspb2; C8h11orf52; Hspb2; LOC689959", "gene_names_refseq": "Hspb2", "protein_names_uniprotkb": "Heat shock protein beta-2; HspB2", "protein_names_refseq": "heat shock 27kD protein 2; heat shock 27kDa protein 2; heat shock protein 2; heat shock protein B2; heat shock protein beta-2 isoform 1; heat shock protein beta-2", "tax_id": 10116, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206)", "pathway": " (rno:161476)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18566458;19715703;34502162;9344664", "class_list": "", "function": "Despite the high level of sequence homology within the small heat-shock proteins (sHSPs) family the biochemical properties of the HSPB2/B3 complex are distinctly different from those of other sHSPs., [RefSeq, PubMed]; May regulate the kinase DMPK., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Systemic delivery of statins after a transient period of retinal ischemia significantly modulated HSP expression in the retina and enhanced RGC survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030054 cell junction", "go_biological_process": "GO:0007525 somatic muscle development;GO:0043066 negative regulation of apoptotic process;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35878-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03238-1", "uniprot_id": [ { "id": "GRAM_RAT", "url": "https://www.uniprot.org/uniprot/Q03238", "type": "external" } ], "mass": 28339.0, "length": 258, "protein_name": "Granzyme M", "gene_name": "Gzmm", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gzmm", "gene_names_refseq": "", "protein_names_uniprotkb": "Granzyme M; 3.4.21.-; Met-ase; Natural killer cell granular protease; RNK-Met-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1447189", "class_list": "", "function": "Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0031640 killing of cells of another organism;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q03238-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18865-1", "uniprot_id": [ { "id": "HXC4_RAT", "url": "https://www.uniprot.org/uniprot/P18865", "type": "external" } ], "mass": 9293.0, "length": 76, "protein_name": "Homeobox protein Hox-C4", "gene_name": "Hoxc4; Hoxc6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxc4; Hoxc6; Hoxc-4; Hoxc6", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-C4; Homeobox protein R3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24459)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2907739", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001501 skeletal system development;GO:0009952 anterior/posterior pattern specification;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18865-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08009-1", "uniprot_id": [ { "id": "GSTM7_RAT", "url": "https://www.uniprot.org/uniprot/P08009", "type": "external" } ], "mass": 25681.0, "length": 218, "protein_name": "Glutathione S-transferase Mu 7", "gene_name": "Gstm2; Gstm4; Gstm7", "organism": "Rat", "refseq_name": "glutathione S-transferase Mu 7", "refseq_ac": [ { "id": "NP_112416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112416", "type": "external" } ], "gene_names_uniprotkb": "Gstm2; Gstm4; Gstm7; Gstm3; Gstm4", "gene_names_refseq": "Gstm3; Gstm7", "protein_names_uniprotkb": "Glutathione S-transferase Mu 7; 2.5.1.18; Chain 4; GST Yb3; GST class-mu 3; Glutathione S-transferase Yb-3", "protein_names_refseq": "GST Yb3; GST class-mu 3; chain 4; glutathione S-transferase Mu 7; glutathione S-transferase Yb-3; glutathione S-transferase, mu type 3 (Yb3)", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81869); (R-RNO-156590)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;3584141;7707876", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0005504 fatty acid binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum;GO:0005737 cytoplasm", "go_biological_process": "GO:0043651 linoleic acid metabolic process;GO:0042178 xenobiotic catabolic process;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0071313 cellular response to caffeine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08009-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08770-1", "uniprot_id": [ { "id": "GPV_RAT", "url": "https://www.uniprot.org/uniprot/O08770", "type": "external" } ], "mass": 63345.0, "length": 567, "protein_name": "Platelet glycoprotein V", "gene_name": "Gp5", "organism": "Rat", "refseq_name": "platelet glycoprotein V precursor", "refseq_ac": [ { "id": "NP_036927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036927", "type": "external" } ], "gene_names_uniprotkb": "Gp5", "gene_names_refseq": "Gp5; PLGPV", "protein_names_uniprotkb": "Platelet glycoprotein V; GPV; Glycoprotein 5", "protein_names_refseq": "GPV; Platelet glycoprotein 5; Platelete glycoprotein 5; glycoprotein 5, platelet; platelet glycoprotein V precursor; platelet glycoprotein V", "tax_id": 10116, "disease": "", "pathway": " (rno:25259); (R-RNO-430116); (R-RNO-9769739); (R-RNO-9769743); (R-RNO-9935598)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9129030", "class_list": "", "function": "The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0009986 cell surface;GO:1990779 glycoprotein Ib-IX-V complex;GO:0016020 membrane", "go_biological_process": "GO:0007597 blood coagulation, intrinsic pathway;GO:0007596 blood coagulation;GO:0007160 cell-matrix adhesion;GO:0051209 release of sequestered calcium ion into cytosol;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O08770-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08934-1", "uniprot_id": [ { "id": "KNG1_RAT", "url": "https://www.uniprot.org/uniprot/P08934", "type": "external" } ], "mass": 70933.0, "length": 639, "protein_name": "Kininogen-1", "gene_name": "Kng1; Kng2l1; Kng2", "organism": "Rat", "refseq_name": "kininogen-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_036873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036873", "type": "external" } ], "gene_names_uniprotkb": "Kng1; Kng2l1; Kng2; Kng2l1; Kng", "gene_names_refseq": "KINKG; KINKH; Kng1; Kng2l1; Kng2; Kngk; Kng; kininogen", "protein_names_uniprotkb": "Kininogen-1", "protein_names_refseq": "K-kininogen; kininogen 2; kininogen-1 isoform 1 precursor; kininogen-1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); high molecular weight kininogen deficiency (Disease Ontology:DOID:0111676); IgA vasculitis (Disease Ontology:DOID:11123); hereditary angioedema (Disease Ontology:DOID:14735); choline deficiency disease (Disease Ontology:DOID:8456); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719)", "pathway": " (rno:25087); (R-RNO-114608); (R-RNO-375276); (R-RNO-381426); (R-RNO-416476); (R-RNO-418594); (R-RNO-8957275); (R-RNO-9855719); (R-RNO-9935598); (R-RNO-9970672)", "pathway_count": 10, "publication_count": 6, "publication_id_list": "17293494;21454685;2413018;2439509;3029068;3818598", "class_list": "", "function": "High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury., [RefSeq, PubMed]; Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting., [UniProtKB]; The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P08933", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006954 inflammatory response;GO:0007162 negative regulation of cell adhesion;GO:0007596 blood coagulation;GO:0042311 vasodilation;GO:0030195 negative regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08934-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00759-1", "uniprot_id": [ { "id": "KLK2_RAT", "url": "https://www.uniprot.org/uniprot/P00759", "type": "external" } ], "mass": 28248.0, "length": 259, "protein_name": "Tonin", "gene_name": "Klk1c2; Klk2", "organism": "Rat", "refseq_name": "tonin precursor", "refseq_ac": [ { "id": "NP_036809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036809", "type": "external" } ], "gene_names_uniprotkb": "Klk1c2; Klk2; Klk-2; Ton", "gene_names_refseq": "KLK2; Klk1c2; Klna1; Ton; rGK-2", "protein_names_uniprotkb": "Tonin; 3.4.21.35; Esterase 1; Glandular kallikrein-2; RSKG-5; S2 kallikrein; rGK-2", "protein_names_refseq": "RSKG-5; S2 kallikrein; esterase 1; glandular kallikrein-2; kallikrein a1; tonin precursor; tonin", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:24841)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "1315752;17366701;20180641;2302205;2550051;26216430;2708383;2821276;2998455;3038148;6320014", "class_list": "", "function": "KLK2 rat gene was expressed at high levels in the submandibular glands of transgenic mice., [RefSeq, PubMed]; The environment of tonin abundance may increase N-domain ACE activity liberated by a secretase able to cleave somatic ACE., [RefSeq, PubMed]; This protein has both trypsin- and chymotrypsin-like activities, being able to release angiotensin II from angiotensin I or angiotensinogen., [UniProtKB]; Tonin in the brain may represent an alternative pathway for angiotensin II generation with effects on the cardiovascular system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00759-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18867-1", "uniprot_id": [ { "id": "HXD3_RAT", "url": "https://www.uniprot.org/uniprot/P18867", "type": "external" } ], "mass": 13044.0, "length": 114, "protein_name": "Homeobox protein Hox-D3", "gene_name": "Hoxd3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxd3; Hoxd-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-D3; Homeobox protein R6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288152)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2907739", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021615 glossopharyngeal nerve morphogenesis;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62959-1", "uniprot_id": [ { "id": "HINT1_RAT", "url": "https://www.uniprot.org/uniprot/P62959", "type": "external" } ], "mass": 13777.0, "length": 126, "protein_name": "Adenosine 5'-monophosphoramidase HINT1", "gene_name": "Hint1l2; Hint1", "organism": "Rat", "refseq_name": "adenosine 5'-monophosphoramidase HINT1", "refseq_ac": [ { "id": "NP_001103077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103077", "type": "external" } ], "gene_names_uniprotkb": "Hint1l2; Hint1; Hint1l1; Hint1l2; Hint; LOC684427; Pkci1", "gene_names_refseq": "Hint1; Pkci; Prkci", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT1; 17 kDa inhibitor of protein kinase C; 3.4.22.-; 3.9.1.-; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; PKCI-1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1", "protein_names_refseq": "17 kDa inhibitor of protein kinase C; PKCI-1; adenosine 5'-monophosphoramidase HINT1; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; protein kinase C inhibitor 1; protein kinase C, iota; protein kinase C-interacting protein 1", "tax_id": 10116, "disease": "Gamstorp-Wohlfart syndrome (Disease Ontology:DOID:0050526)", "pathway": " (rno:684427); (rno:690660); (R-RNO-9824594); (R-RNO-9825892); (R-RNO-9856649)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (By similarity). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (By similarity). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (By similarity). In addition, functions as a scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (By similarity). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RANGAP1 and RGS17 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DEM9;P16436", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0016787 hydrolase activity;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006355 regulation of DNA-templated transcription;GO:0050850 positive regulation of calcium-mediated signaling;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62959-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25102-1", "uniprot_id": [ { "id": "HRH2_RAT", "url": "https://www.uniprot.org/uniprot/P25102", "type": "external" } ], "mass": 40253.0, "length": 358, "protein_name": "Histamine H2 receptor", "gene_name": "Hrh2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hrh2", "gene_names_refseq": "", "protein_names_uniprotkb": "Histamine H2 receptor; Gastric receptor I; H2R; HH2R", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (R-RNO-390650)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1930188", "class_list": "", "function": "G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (By similarity). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; G-protein coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels. This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology. Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:1900139 negative regulation of arachidonate secretion;GO:0007613 memory;GO:0008542 visual learning;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25102-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00918-1", "uniprot_id": [ { "id": "LTBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q00918", "type": "external" } ], "mass": 186599.0, "length": 1712, "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "Ltbp1; Ttc27", "organism": "Rat", "refseq_name": "latent-transforming growth factor beta-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_067598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067598", "type": "external" } ], "gene_names_uniprotkb": "Ltbp1; Ttc27; Ltbp1; Ttc27", "gene_names_refseq": "Ltbp1", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta-1-BP-1; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit", "protein_names_refseq": "LTBP-1; LanC (bacterial lantibiotic synthetase component C)-like 1; TGF-beta-1-BP-1; latent-transforming growth factor beta-binding protein 1 precursor; transforming growth factor beta-1-binding protein 1; transforming growth factor beta-1-masking protein large subunit; transforming growth factor-beta (TGF-beta) masking protein large subunit", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); cutis laxa (Disease Ontology:DOID:3144)", "pathway": " (rno:298782); (rno:59107); (R-RNO-2129379); (R-RNO-2173789); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10743502;11104663;2247454;22673903;7593177", "class_list": "", "function": "Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:7593177). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 18, "predicted_n_glycosites": 7, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005509 calcium ion binding;GO:0050431 transforming growth factor beta binding;GO:0050436 microfibril binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030425 dendrite;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0032967 positive regulation of collagen biosynthetic process;GO:0003281 ventricular septum development;GO:0035904 aorta development;GO:0060976 coronary vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00918-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09635-1", "uniprot_id": [ { "id": "HXA4_RAT", "url": "https://www.uniprot.org/uniprot/P09635", "type": "external" } ], "mass": 8346.0, "length": 67, "protein_name": "Homeobox protein Hox-A4", "gene_name": "Hoxa4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxa4; Hox-a4; LOC100912525", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A4; Homeobox protein R2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100912525)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2886401;7702549", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis;GO:0001501 skeletal system development;GO:0048562 embryonic organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09635-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M707-1", "uniprot_id": [ { "id": "NCF1_RAT", "url": "https://www.uniprot.org/uniprot/F1M707", "type": "external" } ], "mass": 44712.0, "length": 389, "protein_name": "Neutrophil cytosolic factor 1", "gene_name": "Ncf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neutrophil cytosolic factor 1; NCF-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive chronic granulomatous disease 1 (Disease Ontology:DOID:0070192); Williams-Beuren syndrome (Disease Ontology:DOID:1928); chronic granulomatous disease (Disease Ontology:DOID:3265); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (R-RNO-1222556); (R-RNO-1236973); (R-RNO-3299685); (R-RNO-4420097); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0035091 phosphatidylinositol binding;GO:0016176 superoxide-generating NADPH oxidase activator activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0070947 neutrophil-mediated killing of fungus;GO:1903409 reactive oxygen species biosynthetic process;GO:0001878 response to yeast;GO:0006954 inflammatory response;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1M707-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLZ7-1", "uniprot_id": [ { "id": "IMDH1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLZ7", "type": "external" } ], "mass": 55293.0, "length": 514, "protein_name": "Inosine-5'-monophosphate dehydrogenase 1", "gene_name": "Impdh1", "organism": "Rat", "refseq_name": "inosine-5'-monophosphate dehydrogenase 1 isoform 2", "refseq_ac": [ { "id": "NP_001385786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385786", "type": "external" } ], "gene_names_uniprotkb": "Impdh1; IMPDH", "gene_names_refseq": "IMPD 1; IMPDH 1; Impdh1", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase 1; 1.1.1.205; IMP dehydrogenase 1; IMPD 1; IMPDH 1", "protein_names_refseq": "IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP dehydrogenase 1; inosine 5'-phosphate dehydrogenase 1; inosine-5'-monophosphate dehydrogenase 1 isoform 2; inosine-5'-monophosphate dehydrogenase 1", "tax_id": 10116, "disease": "Leber congenital amaurosis 11 (Disease Ontology:DOID:0110216); retinitis pigmentosa 10 (Disease Ontology:DOID:0110388); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (rno:362329); (R-RNO-6798695); (R-RNO-73817); (R-RNO-9748787)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" 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"3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060041 retina development in camera-type eye;GO:0046651 lymphocyte proliferation;GO:0006177 GMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006183 GTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLZ7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22771-1", "uniprot_id": [ { "id": "GLRA2_RAT", "url": "https://www.uniprot.org/uniprot/P22771", "type": "external" } ], "mass": 52053.0, "length": 452, "protein_name": "Glycine receptor subunit alpha-2", "gene_name": "Glra2", "organism": "Rat", "refseq_name": "glycine receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_036700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036700", "type": "external" } ], "gene_names_uniprotkb": "Glra2", "gene_names_refseq": "Glra2; RNNEOGLY", "protein_names_uniprotkb": "Glycine receptor subunit alpha-2; Glycine receptor strychnine-binding subunit", "protein_names_refseq": "Glycine receptor alpha 2 subunit (glycine receptor, neonatal); glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-2 precursor; glycine receptor subunit alpha-2-like", "tax_id": 10116, "disease": "congenital stromal corneal dystrophy (Disease Ontology:DOID:0060445); syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422); gestational diabetes (Disease Ontology:DOID:11714); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24397); (R-RNO-112314)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12124753;1645300;1707830;2176511;22330726;23079787;27382060;38017313", "class_list": "", "function": "Alpha2 subunits determine the picrotin sensitivity of alpha1alpha2-heteromeric receptors. Direct gating of the alpha2 subunit is not required for this picrotin inhibition., [RefSeq, PubMed]; Data show that the current-voltage relationships of homomeric channels formed by the alpha2 or alpha3 subunits change upon receptor desensitization from a linear to an inwardly rectifying shape, in contrast to their heteromeric counterparts., [RefSeq, PubMed]; Role of Nova-1 in regulating alpha2N, a novel glycine receptor splice variant, in developing spinal cord neurons., [RefSeq, PubMed]; Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:2176511). Plays a role in synaptic plasticity. Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol., [UniProtKB, PubMed, UniProtKB]; This study demonistrated that glycine receptor alpha 2 subunit decrease in developmental brain., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91W28", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0034707 chloride channel complex;GO:0042995 cell projection;GO:0098690 glycinergic synapse", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0021510 spinal cord development;GO:0034220 monoatomic ion transmembrane transport;GO:0007416 synapse assembly;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P22771-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27926-1", "uniprot_id": [ { "id": "HXK3_RAT", "url": "https://www.uniprot.org/uniprot/P27926", "type": "external" } ], "mass": 100254.0, "length": 924, "protein_name": "Hexokinase-3", "gene_name": "Hk3", "organism": "Rat", "refseq_name": "hexokinase-3", "refseq_ac": [ { "id": "NP_071515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071515", "type": "external" } ], "gene_names_uniprotkb": "Hk3", "gene_names_refseq": "Hk3; RNU73859", "protein_names_uniprotkb": "Hexokinase-3; 2.7.1.1; HK III; Hexokinase type III; Hexokinase-C", "protein_names_refseq": "HK III; hexokinase 3 (white cell); hexokinase type III; hexokinase-3; hexokinase-C", "tax_id": 10116, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:25060); (R-RNO-6798695); (R-RNO-70171)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1897938;29196144;5871820;7044667", "class_list": "", "function": "Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; HK3 may be involved in the pathologic process ofspinal cord injury by promoting glucose metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497A1", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", 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"type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", 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"https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process;GO:0006002 fructose 6-phosphate metabolic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27926-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07917-1", "uniprot_id": [ { "id": "NR4A2_RAT", "url": "https://www.uniprot.org/uniprot/Q07917", "type": "external" } ], "mass": 66622.0, "length": 598, "protein_name": "Nuclear receptor subfamily 4 group A member 2", "gene_name": "Nr4a2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 4 group A member 2", "refseq_ac": [ { "id": "NP_062201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062201", "type": "external" } ], "gene_names_uniprotkb": "Nr4a2; Hzf-3; Nurr1; Rnr1", "gene_names_refseq": "Nr4a2; Nurr1; RNR1", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 2; NUR-related factor 1; Nuclear orphan receptor HZF-3; Orphan nuclear receptor NURR1; RNR-1; Regenerating liver nuclear receptor 1; SL-322", "protein_names_refseq": "NUR-related factor 1; RNR-1; SL-322; nuclear orphan receptor HZF-3; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4 group A member 2 variant TINUR; nuclear receptor subfamily 4 group A member 2; nur related protein 1; orphan nuclear receptor NURR1; regenerating liver nuclear receptor 1", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:54278); (R-RNO-383280)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18951485;33864663;34774582;35365988;37621064;7914660;8473329;9221923", "class_list": "", "function": "(-)-Epigallocatechin-3-gallate promotes intestinal epithelial proliferation and barrier function after ischemia/reperfusion injury via activation of Nurr1., [RefSeq, PubMed]; NFkappaB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease., [RefSeq, PubMed]; NR4A2 alleviates cardiomyocyte loss and myocardial injury in rats by transcriptionally suppressing CCR5 and inducing M2 polarization of macrophages., [RefSeq, PubMed]; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (By similarity). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver-specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with NR4A1 (PubMed:8473329)., [UniProtKB, PubMed, UniProtKB]; [Protective effect of nuclear receptor related 1 (Nurr1) on nerves in rats with cerebral occlusion/reperfusion injury and its mechanism]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35865", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07917-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42676-1", "uniprot_id": [ { "id": "NEUL_RAT", "url": "https://www.uniprot.org/uniprot/P42676", "type": "external" } ], "mass": 80254.0, "length": 704, "protein_name": "Neurolysin, mitochondrial", "gene_name": "Nln", "organism": "Rat", "refseq_name": "neurolysin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_446422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446422", "type": "external" } ], "gene_names_uniprotkb": "Nln", "gene_names_refseq": "Nln", "protein_names_uniprotkb": "Neurolysin, mitochondrial; 3.4.24.16; MEP; Microsomal endopeptidase; Mitochondrial oligopeptidase M; Neurotensin endopeptidase", "protein_names_refseq": "MEP; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial precursor; neurolysin, mitochondrial; neurotensin endopeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:117041); (R-RNO-375276)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11248043;12192079;12500972;18077343;23412923;25378390;29393594;7592986;7836437", "class_list": "", "function": "Data indicate that the inhibitor binds away from the catalytic site of neuropeptidase neurolysin., [RefSeq, PubMed]; Data report mapping of the positions of the 224 surface residues that differ in sequence between thimet oligopeptidase and neurolysin onto the surface of the neurolysin crystal structure., [RefSeq, PubMed]; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (PubMed:7836437). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:12500972, PubMed:18077343)., [UniProtKB, PubMed, PubMed, PubMed]; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neurolysin was identified as a non-AT1 and non-AT2 binding site for Angiotensin II, suggesting that neurolysin may significantly affect the activity of the renin-angiotensin system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GQQ4", "ec_number_list": [ { "id": "3.4.24.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.16", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0042277 peptide binding;GO:0008233 peptidase activity;GO:0070012 oligopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1902809 regulation of skeletal muscle fiber differentiation;GO:0006508 proteolysis;GO:0043171 peptide catabolic process;GO:0030163 protein catabolic process;GO:0006111 regulation of gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P42676-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56574-1", "uniprot_id": [ { "id": "IDHP_RAT", "url": "https://www.uniprot.org/uniprot/P56574", "type": "external" } ], "mass": 50967.0, "length": 452, "protein_name": "Isocitrate dehydrogenase [NADP], mitochondrial", "gene_name": "Idh2", "organism": "Rat", "refseq_name": "isocitrate dehydrogenase [NADP], mitochondrial precursor", "refseq_ac": [ { "id": "NP_001014183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014183", "type": "external" } ], "gene_names_uniprotkb": "Idh2", "gene_names_refseq": "Idh2", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP], mitochondrial; 1.1.1.42; ICD-M; IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "ICD-M; IDH; IDP; NADP(+)-specific ICDH; isocitrate dehydrogenase (NADP(+)) 2, mitochondrial; isocitrate dehydrogenase 2 (NADP+), mitochondrial; isocitrate dehydrogenase [NADP], mitochondrial precursor; isocitrate dehydrogenase [NADP], mitochondrial; oxalosuccinate decarboxylase", "tax_id": 10116, "disease": "bone remodeling disease (Disease Ontology:DOID:0080005); D-2-hydroxyglutaric aciduria 2 (Disease Ontology:DOID:0111352); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:361596); (R-RNO-2151201); (R-RNO-71403); (R-RNO-9837999); (R-RNO-9854311)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "26446791;34502162;38843836", "class_list": "", "function": "Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6DGF1", "ec_number_list": [ { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006741 NADP+ biosynthetic process;GO:1903976 negative regulation of glial cell migration;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0006099 tricarboxylic acid cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56574-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17982-1", "uniprot_id": [ { "id": "NAR2A_RAT", "url": "https://www.uniprot.org/uniprot/P17982", "type": "external" } ], "mass": 31388.0, "length": 275, "protein_name": "T-cell ecto-ADP-ribosyltransferase 1", "gene_name": "Art2a; Art2b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Art2a; Art2b; Rt6-a; Rt6-b; Rt6", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell ecto-ADP-ribosyltransferase 1; 2.4.2.31; 3.2.2.5; Alloantigen Rt6.1; Mono(ADP-ribosyl)transferase 2A; NAD(+) glycohydrolase; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1; T-cell mono(ADP-ribosyl)transferase 1; T-cell surface protein Rt6.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "branchiootorenal syndrome (Disease Ontology:DOID:14702); eye disease (Disease Ontology:DOID:5614)", "pathway": " (rno:293152)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11220625;12270706;12939142;2129547;2300588;2632369;8144525;8690084;8757323", "class_list": "", "function": "Has NAD(+) glycohydrolase activity and extremely low ADP-ribosyltransferase activity., [UniProtKB]; Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity (to a lesser extent)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" } ], "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0003953 NAD+ nucleosidase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0019677 NAD+ catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P17982-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88488-1", "uniprot_id": [ { "id": "PTPRQ_RAT", "url": "https://www.uniprot.org/uniprot/O88488", "type": "external" } ], "mass": 256824.0, "length": 2302, "protein_name": "Phosphatidylinositol phosphatase PTPRQ", "gene_name": "Ptprq", "organism": "Rat", "refseq_name": "phosphatidylinositol phosphatase PTPRQ precursor", "refseq_ac": [ { "id": "NP_075214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075214", "type": "external" } ], "gene_names_uniprotkb": "Ptprq; Ptpgmc1", "gene_names_refseq": "Ptprq; rPTP-GMC1", "protein_names_uniprotkb": "Phosphatidylinositol phosphatase PTPRQ; 3.1.3.36; 3.1.3.67; 3.1.3.86; 3.1.3.95; PTP-RQ; Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1; R-PTP-Q; Receptor-type tyrosine-protein phosphatase Q; rPTP-GMC1", "protein_names_refseq": "PTP-RQ; R-PTP-Q; glomerular mesangial cell receptor protein-tyrosine phosphatase; phosphatidylinositol phosphatase PTPRQ precursor; phosphatidylinositol phosphatase PTPRQ; phosphotidylinositol phosphatase PTPRQ; protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1; receptor-type tyrosine-protein phosphatase Q", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 73 (Disease Ontology:DOID:0080269); autosomal recessive nonsyndromic deafness 84A (Disease Ontology:DOID:0110529)", "pathway": " (rno:360417)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12802008;12837292;9727007", "class_list": "", "function": "Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3 (PubMed:12802008). Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring (PubMed:12802008). Has low tyrosine-protein phosphatase activity in vitro; however, the relevance of such activity in vivo is unclear (PubMed:12802008). Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 level in MSCs and preadipocyte cells (By similarity). Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; PTPRQ represents a subtype of the PTPases whose biological activities result from its PIPase activity rather than its PTPase activity, [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 15, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane;GO:0032421 stereocilium bundle;GO:0120044 stereocilium base", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0050885 neuromuscular process controlling balance;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0002244 hematopoietic progenitor cell differentiation;GO:0060116 vestibular receptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88488-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12371-1", "uniprot_id": [ { "id": "FCERA_RAT", "url": "https://www.uniprot.org/uniprot/P12371", "type": "external" } ], "mass": 27793.0, "length": 245, "protein_name": "High affinity immunoglobulin epsilon receptor subunit alpha", "gene_name": "Fcer1a", "organism": "Rat", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_036856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036856", "type": "external" } ], "gene_names_uniprotkb": "Fcer1a; Fce1a", "gene_names_refseq": "Fcer1a; Iger01; RATIGER01", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha", "protein_names_refseq": "Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; Fc receptor, IgE, high affinity I, alpha polypeptide; alpha polypeptide; fc-epsilon RI-alpha; fcERI; high affinity immunoglobulin epsilon receptor subunit alpha precursor; high affinity immunoglobulin epsilon receptor subunit alpha; igE Fc receptor subunit alpha", "tax_id": 10116, "disease": "Peters anomaly (Disease Ontology:DOID:0060673); anterior segment dysgenesis 6 (Disease Ontology:DOID:0080611); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); buphthalmos (Disease Ontology:DOID:11211); hydrophthalmos (Disease Ontology:DOID:11212); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841); breast adenocarcinoma (Disease Ontology:DOID:3458); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25047); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "17728245;19103603;22820943;24497038;24791697;2522441;25289695;29029788;2959318;2964640;2969594", "class_list": "", "function": "Data suggest M2PK (M2-type pyruvate kinase) is modulated in mast cell degranulation via IgE/FCERI signaling; immediate inhibition of M2PK involves tyrosine phosphorylation; subsequently fructose-1,6-biphosphate accumulates and activates M2PK., [RefSeq, PubMed]; Differential Ca(2+) mobilization and mast cell degranulation by FcepsilonRI- and GPCR-mediated signaling has been reported., [RefSeq, PubMed]; High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions., [UniProtKB, UniProtKB]; NK-1 receptor is required for the activation of RBL-2H3 cells following FcepsilonRIota engagement and involved in the regulation of mitogen-activated protein kinase signaling pathways, [RefSeq, PubMed]; PTP-PEST expression was significantly induced upon FcepsilonRI-crosslinking, and aggregation of FcepsilonRI induced the phosphorylation of PTP-PEST at Ser39, thus resulting in the suppression of PTP activity., [RefSeq, PubMed]; This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P12840", "ec_number_list": [], "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0019768 high-affinity IgE receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032752 positive regulation of interleukin-3 production;GO:0006955 immune response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043306 positive regulation of mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12371-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31422-1", "uniprot_id": [ { "id": "GRM3_RAT", "url": "https://www.uniprot.org/uniprot/P31422", "type": "external" } ], "mass": 98960.0, "length": 879, "protein_name": "Metabotropic glutamate receptor 3", "gene_name": "Grm3", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 3 precursor", "refseq_ac": [ { "id": "NP_001099182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099182", "type": "external" } ], "gene_names_uniprotkb": "Grm3; Gprc1c; Mglur3", "gene_names_refseq": "Grm3; mGluR3", "protein_names_uniprotkb": "Metabotropic glutamate receptor 3; mGluR3", "protein_names_refseq": "glutamate receptor, metabotropic 3; metabotropic glutamate receptor 3 precursor; metabotropic glutamate receptor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:24416); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11850456;1309649;17360426;24090084;30005976;31050077;31710636;38843836", "class_list": "", "function": "ERalphaDelta4, an ERalpha splice variant missing exon4, interacts with caveolin-3 and mGluR2/3., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB]; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB, UniProtKB, UniProtKB]; Significant decrease in mGluR5 mRNA expression with a resultant increased expression of mGluR3 mRNA expression and hypermethylation of mGluR1 gene across both generations of rats, is reported. Publication Status: Online-Only, [RefSeq, PubMed]; Studies illustrate the significant contribution of mGluR2 to the antipsychotic-like, sleep and EEG effects of drugs acting on group II mGluRs; however, we also provide evidence of a role for mGluR3 activity in the control of sleep and wake cortical theta and gamma oscillations, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0097110 scaffold protein binding;GO:0001641 group II metabotropic glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0019233 sensory perception of pain;GO:0050804 modulation of chemical synaptic transmission;GO:0033554 cellular response to stress;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P31422-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22756-1", "uniprot_id": [ { "id": "GRIK1_RAT", "url": "https://www.uniprot.org/uniprot/P22756", "type": "external" } ], "mass": 107840.0, "length": 949, "protein_name": "Glutamate receptor ionotropic, kainate 1", "gene_name": "Grik1", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, kainate 1 isoform 3", "refseq_ac": [ { "id": "NP_001104584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104584", "type": "external" } ], "gene_names_uniprotkb": "Grik1; Glur5", "gene_names_refseq": "GluK1; GluR5; Grik1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 1; GluK1; GluR-5; GluR5; Glutamate receptor 5", "protein_names_refseq": "glutamate receptor 5; glutamate receptor ionotropic, kainate 1 isoform 3; glutamate receptor ionotropic, kainate 1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); childhood absence epilepsy (Disease Ontology:DOID:1825)", "pathway": " (rno:29559); (R-RNO-451307); (R-RNO-451308)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10023812;11425885;12873388;1322826;1373382;15710405;15721240;16540562;17062563;1977421;25139762;28100490;30421168;30451858;9254673", "class_list": "", "function": "Gluk1 and NETO1 specifically promote dendrite growth of interneurons in the visual cortex., [RefSeq, PubMed]; Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; In the CA1 hippocampal pyramidal cell, GluK1 had no effect on synaptic transmission. GluK1 which requires the auxiliary subunits Neto1 and Neto2 for surface and synaptic trafficking. It is the amino-terminal domains of GluK1 and GluK2 that control their strikingly different trafficking properties., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0042802 identical protein binding;GO:0097110 scaffold protein binding;GO:0000149 SNARE binding;GO:0004970 glutamate-gated receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P22756-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48550-1", "uniprot_id": [ { "id": "KCNJ6_RAT", "url": "https://www.uniprot.org/uniprot/P48550", "type": "external" } ], "mass": 48640.0, "length": 425, "protein_name": "G protein-activated inward rectifier potassium channel 2", "gene_name": "Kcnj6", "organism": "Rat", "refseq_name": "G protein-activated inward rectifier potassium channel 2 isoform 1", "refseq_ac": [ { "id": "NP_037324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037324", "type": "external" } ], "gene_names_uniprotkb": "Kcnj6; Girk2; Kcnj7", "gene_names_refseq": "Kcnj6", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 2; BIR1; GIRK-2; Inward rectifier K(+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6", "protein_names_refseq": "BIR1; G protein-activated inward rectifier potassium channel 2 isoform 1; GIRK-2; GIRK2; KATP-2; g protein-activated inward rectifier potassium channel 2; inward rectifier K(+) channel Kir3.2; potassium channel, inwardly rectifying subfamily J member 6; potassium voltage-gated channel subfamily J member 6", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25743); (R-RNO-1296041); (R-RNO-997272)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17828261;26460748;28291959;28951616;31386893;36602604;7601286;7626127;9486652", "class_list": "", "function": "Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1A and PPAR-gamma pathway., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G protein-coupled receptors., [UniProtKB, PubMed, PubMed]; Inwardly rectifying K+ channels coupled to 5-HT1A autoreceptors display pharmacological properties generally expected for neuronal GIRK channels, but different from GIRK1-GIRK2 heteromers Publication Status: Online-Only, [RefSeq, PubMed]; Study is first to show direct cleavage of GIRK1 and GIRK2 subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390) and GIRK2 (349YEVD352) and suggests the possible role of caspase-3 mediated down-regulation of GIRK channel function and expression in hippocampal neuronal injury during prolonged epileptic seizures. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Mitochondrial KATP Channels in the Infarct-Reducing Effect of Normobaric Hypoxia., [RefSeq, PubMed]; The opening of ATP-sensitive K+ channels protects cardiomyocytes against the high glucose-induced injury and inflammation by inhibiting the ROS-TLR4-necroptosis pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0001965 G-protein alpha-subunit binding;GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051602 response to electrical stimulus;GO:0071315 cellular response to morphine;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48550-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08025-1", "uniprot_id": [ { "id": "IGF1_RAT", "url": "https://www.uniprot.org/uniprot/P08025", "type": "external" } ], "mass": 17079.0, "length": 153, "protein_name": "Insulin-like growth factor 1", "gene_name": "Igf1", "organism": "Rat", "refseq_name": "insulin-like growth factor 1 isoform a preproprotein", "refseq_ac": [ { "id": "NP_001075946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075946", "type": "external" } ], "gene_names_uniprotkb": "Igf1; Igf-1", "gene_names_refseq": "IGF; Igf1", "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; Somatomedin", "protein_names_refseq": "IGF-I; Insulin-like growth factor I; insulin-like growth factor 1 isoform a preproprotein; somatomedin", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); rheumatic heart disease (Disease Ontology:DOID:0050827); stroke (Disease Ontology:DOID:0051061); pycnodysostosis (Disease Ontology:DOID:0080038); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); PEHO syndrome (Disease Ontology:DOID:0080539); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); microcephaly (Disease Ontology:DOID:10907); IgA vasculitis (Disease Ontology:DOID:11123); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Graves' disease (Disease Ontology:DOID:12361); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); cholestasis (Disease Ontology:DOID:13580); folic acid deficiency anemia (Disease Ontology:DOID:14026); alcoholic neuropathy (Disease Ontology:DOID:14183); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); carotid artery disease (Disease Ontology:DOID:3407); Noonan syndrome (Disease Ontology:DOID:3490); Turner syndrome (Disease Ontology:DOID:3491); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); coronary stenosis (Disease Ontology:DOID:4248); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); uveal melanoma (Disease Ontology:DOID:6039); acne (Disease Ontology:DOID:6543); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); Laron syndrome (Disease Ontology:DOID:9521); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia (Disease Ontology:DOID:987)", "pathway": " (rno:24482); (R-RNO-114608); (R-RNO-2404192); (R-RNO-2428928); (R-RNO-2428933); (R-RNO-381426); (R-RNO-422085)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "1368571;20724525;21983076;2538424;3034909;3453891;3595538;3652906;3658684;38085649;38622478;38632221;39438882", "class_list": "", "function": "GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p. Publication Status: Online-Only, [RefSeq, PubMed]; Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats., [RefSeq, PubMed]; The Effect of Different Exercise Modalities on Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced Obesity Rat Models: Implication on Glucose and Lactate Transport, Igf1, and Igf1R-dependent Pathways., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (PubMed:20724525)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08024", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0014896 muscle hypertrophy;GO:0014904 myotube cell development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08025-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9R8-1", "uniprot_id": [ { "id": "HNRPC_RAT", "url": "https://www.uniprot.org/uniprot/G3V9R8", "type": "external" } ], "mass": 32857.0, "length": 298, "protein_name": "Heterogeneous nuclear ribonucleoprotein C", "gene_name": "Hnrnpc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hnrnpc; Hnrpc; LOC100911576", "gene_names_refseq": "", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein C; hnRNP C; hnRNP core protein C", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 74 (Disease Ontology:DOID:0061047); atherosclerosis (Disease Ontology:DOID:1936); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:290046); (R-RNO-4570464); (R-RNO-72163); (R-RNO-72203); (R-RNO-9013418); (R-RNO-9013422); (R-RNO-9770562)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "16641100;18683930;22673903", "class_list": "", "function": "Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4ACR0;Q4V8K6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0004857 enzyme inhibitor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0000398 mRNA splicing, via spliceosome;GO:0090367 negative regulation of mRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V9R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97779-1", "uniprot_id": [ { "id": "HMMR_RAT", "url": "https://www.uniprot.org/uniprot/P97779", "type": "external" } ], "mass": 57858.0, "length": 498, "protein_name": "Hyaluronan-mediated motility receptor", "gene_name": "Hmmr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hmmr; Ihabp; Rhamm", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronan-mediated motility receptor; Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility", "protein_names_refseq": "", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity (By similarity). May act as a regulator of adipogenisis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0009986 cell surface", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007010 cytoskeleton organization;GO:0006898 receptor-mediated endocytosis;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P97779-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35560-1", "uniprot_id": [ { "id": "KCNJ1_RAT", "url": "https://www.uniprot.org/uniprot/P35560", "type": "external" } ], "mass": 44963.0, "length": 391, "protein_name": "ATP-sensitive inward rectifier potassium channel 1", "gene_name": "Kcnj1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnj1; Romk1", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; KAB-1; Potassium channel, inwardly rectifying subfamily J member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Bartter disease type 2 (Disease Ontology:DOID:0110143); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (rno:24521); (R-RNO-1296067)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10069985;7611454;7680431;8166245;9015377;9486652", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88639;O88640;Q9QUR5", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005267 potassium channel activity;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0072359 circulatory system development;GO:0006811 monoatomic ion transport;GO:0043066 negative regulation of apoptotic process;GO:0001822 kidney development;GO:0001894 tissue homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35560-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97576-1", "uniprot_id": [ { "id": "GRPE1_RAT", "url": "https://www.uniprot.org/uniprot/P97576", "type": "external" } ], "mass": 24297.0, "length": 217, "protein_name": "GrpE protein homolog 1, mitochondrial", "gene_name": "Grpel1", "organism": "Rat", "refseq_name": "grpE protein homolog 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077813", "type": "external" } ], "gene_names_uniprotkb": "Grpel1; Grepel1", "gene_names_refseq": "GrpE#1; GrpE1; Grpel1", "protein_names_uniprotkb": "GrpE protein homolog 1, mitochondrial; Mt-GrpE#1", "protein_names_refseq": "grpE protein homolog 1, mitochondrial precursor; grpE protein homolog 1, mitochondrial; mt-GrpE#1; stress-inducible chaperone mt-GrpE#1", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:79563)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12505684;8914984", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins., [UniProtKB, UniProtKB, UniProtKB]; Reverse transcription-polymerase chain reaction and in situ hybridization analyses showed significant induction of GrpE mRNA in the ischemic cortex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRA3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0006457 protein folding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97576-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZKF5-1", "uniprot_id": [ { "id": "HTRA4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZKF5", "type": "external" } ], "mass": 52193.0, "length": 488, "protein_name": "Serine protease HTR4", "gene_name": "Htra4", "organism": "Rat", "refseq_name": "serine protease HTR4 precursor", "refseq_ac": [ { "id": "NP_001100791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100791", "type": "external" } ], "gene_names_uniprotkb": "Htra4", "gene_names_refseq": "Htra4; RGD1306242", "protein_names_uniprotkb": "Serine protease HTR4; 3.4.21.-; High-temperature requirement factor A4", "protein_names_refseq": "high-temperature requirement factor A4; probable serine protease HTRA4; serine protease HTR4 precursor; serine protease HTR4", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:306564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine protease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZKF5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70215-1", "uniprot_id": [ { "id": "NKG2D_RAT", "url": "https://www.uniprot.org/uniprot/O70215", "type": "external" } ], "mass": 24438.0, "length": 215, "protein_name": "NKG2-D type II integral membrane protein", "gene_name": "Klrk1", "organism": "Rat", "refseq_name": "NKG2-D type II integral membrane protein", "refseq_ac": [ { "id": "NP_598196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598196", "type": "external" } ], "gene_names_uniprotkb": "Klrk1; Nkg2d; Nkrp2", "gene_names_refseq": "Klrk1; NKG2D; Nkrp2", "protein_names_uniprotkb": "NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKG2-D-activating NK receptor; NKLLR; NKR-P2", "protein_names_refseq": "NK cell receptor D; NK lectin-like receptor; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; NKR-P2, ortholog of human NKG2D; killer cell lectin-like receptor subfamily K, member 1", "tax_id": 10116, "disease": "ABCD syndrome (Disease Ontology:DOID:0050600); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); Waardenburg syndrome type 4A (Disease Ontology:DOID:0110953); sensorineural hearing loss (Disease Ontology:DOID:10003); Hirschsprung's disease (Disease Ontology:DOID:10487); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); anogenital venereal wart (Disease Ontology:DOID:11168); megacolon (Disease Ontology:DOID:11372); hepatitis C (Disease Ontology:DOID:1883); asthma (Disease Ontology:DOID:2841); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); tuberculosis (Disease Ontology:DOID:399); histiocytoma (Disease Ontology:DOID:4231); myocardial infarction (Disease Ontology:DOID:5844); lymphopenia (Disease Ontology:DOID:614); pulmonary hypertension (Disease Ontology:DOID:6432); hepatopulmonary syndrome (Disease Ontology:DOID:900); Waardenburg syndrome (Disease Ontology:DOID:9258); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24934); (R-RNO-198933); (R-RNO-2424491)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12421908;15048723;9620593", "class_list": "", "function": "Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins., [UniProtKB, PubMed]; NKG2D acts as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032394 MHC class Ib receptor activity;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0030246 carbohydrate binding;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0050830 defense response to Gram-positive bacterium;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70215-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08656-1", "uniprot_id": [ { "id": "HXA1_RAT", "url": "https://www.uniprot.org/uniprot/O08656", "type": "external" } ], "mass": 36124.0, "length": 333, "protein_name": "Homeobox protein Hox-A1", "gene_name": "Hoxa1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxa1; NEWGENE_2812", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Athabaskan brainstem dysgenesis syndrome (Disease Ontology:DOID:0050682); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:103690132)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0021570 rhombomere 4 development;GO:0021571 rhombomere 5 development;GO:0021754 facial nucleus development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O08656-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48004-1", "uniprot_id": [ { "id": "PSA7_RAT", "url": "https://www.uniprot.org/uniprot/P48004", "type": "external" } ], "mass": 28326.0, "length": 254, "protein_name": "Proteasome subunit alpha type-7", "gene_name": "Psma7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psma7", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome subunit alpha type-7; Proteasome subunit RC6-1; Proteasome subunit alpha-4; alpha-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 1, "publication_id_list": "7578256", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48004-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51514-1", "uniprot_id": [ { "id": "HTF4_RAT", "url": "https://www.uniprot.org/uniprot/P51514", "type": "external" } ], "mass": 75896.0, "length": 707, "protein_name": "Transcription factor 12", "gene_name": "Tcf12", "organism": "Rat", "refseq_name": "transcription factor 12", "refseq_ac": [ { "id": "NP_037308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037308", "type": "external" } ], "gene_names_uniprotkb": "Tcf12", "gene_names_refseq": "SCBP alpha; SCBPA; Tcf12", "protein_names_uniprotkb": "Transcription factor 12; DNA-binding protein HTF4; E-box-binding protein; SCBP-alpha; Salivary-specific cAMP response element-binding protein alpha; TCF-12; Transcription factor HTF-4", "protein_names_refseq": "DNA-binding protein HTF4; E-box-binding protein; SCBP-alpha; TCF-12; salivary-specific cAMP response element-binding protein alpha; transcription factor 12; transcription factor HTF-4", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); craniosynostosis 3 (Disease Ontology:DOID:0061011); hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25720); (R-RNO-525793); (R-RNO-8939236)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21982980;22673903;7683670;8422988", "class_list": "", "function": "The learning and memory deficits in Tcf12 animals are likely due to neuropathology associated with Tcf12 gene expression., [RefSeq, PubMed]; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0046332 SMAD binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51514-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63140-1", "uniprot_id": [ { "id": "NFYB_RAT", "url": "https://www.uniprot.org/uniprot/P63140", "type": "external" } ], "mass": 22787.0, "length": 207, "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "Nfyb", "organism": "Rat", "refseq_name": "nuclear transcription factor Y subunit beta", "refseq_ac": [ { "id": "NP_113741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113741", "type": "external" } ], "gene_names_uniprotkb": "Nfyb", "gene_names_refseq": "CBF-B; CBFB; Nfya; Nfyb", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit beta; CAAT box DNA-binding protein subunit B; CBF-B; CCAAT-binding transcription factor subunit B; NF-YB; Nuclear transcription factor Y subunit B", "protein_names_refseq": "CAAT box DNA-binding protein subunit B; CBF-A; CCAAT binding transcription factor of CBF-B/NFY-B; CCAAT-binding transcription factor subunit A; CCAAT-binding transcription factor subunit B; NF-YB; nuclear transcription factor - Y beta; nuclear transcription factor Y subunit B; nuclear transcription factor Y subunit beta; nuclear transcription factor-Y beta", "tax_id": 10116, "disease": "", "pathway": " (rno:25336)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2266139", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P22569;Q5FVT0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63140-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83645-1", "uniprot_id": [ { "id": "GPX2_RAT", "url": "https://www.uniprot.org/uniprot/P83645", "type": "external" } ], "mass": 22014.0, "length": 190, "protein_name": "Glutathione peroxidase 2", "gene_name": "Gpx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpx2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione peroxidase 2; 1.11.1.12; 1.11.1.9; GPx-2; GPx-GI; GSHPx-2; GSHPx-GI; Glutathione peroxidase-gastrointestinal; Phospholipid hydroperoxide glutathione peroxidase GPX2", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal carcinoma (Disease Ontology:DOID:0080199); ulcerative colitis (Disease Ontology:DOID:8577); alcoholic gastritis (Disease Ontology:DOID:8680); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29326); (R-RNO-2142712); (R-RNO-2142770); (R-RNO-3299685); (R-RNO-5628897)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "22673903;8889548;9685647", "class_list": "", "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:9685647). Can reduce small soluble hydroperoxide such as H2O2 (PubMed:9685647). Can reduce cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. Cannot reduce phosphatidycholine hydroperoxide (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0009609 response to symbiotic bacterium;GO:0001659 temperature homeostasis;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83645-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97679-1", "uniprot_id": [ { "id": "MLH1_RAT", "url": "https://www.uniprot.org/uniprot/P97679", "type": "external" } ], "mass": 84540.0, "length": 757, "protein_name": "DNA mismatch repair protein Mlh1", "gene_name": "Mlh1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mlh1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA mismatch repair protein Mlh1; MutL protein homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); hereditary nonpolyposis colorectal cancer type 2 (Disease Ontology:DOID:0070274); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); colon cancer (Disease Ontology:DOID:219); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary ovarian insufficiency (Disease Ontology:DOID:5426); malignant pleural mesothelioma (Disease Ontology:DOID:7474); sporadic breast cancer (Disease Ontology:DOID:8029); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:81685); (R-RNO-5358565)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (Mlh1-Pms2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with Mlh3 to form MutL gamma which plays a role in meiosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005712 chiasma;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0000710 meiotic mismatch repair;GO:0045143 homologous chromosome segregation;GO:0007060 male meiosis chromosome segregation;GO:0016321 female meiosis chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97679-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A523-1", "uniprot_id": [ { "id": "NLRP3_RAT", "url": "https://www.uniprot.org/uniprot/D4A523", "type": "external" } ], "mass": 118540.0, "length": 1035, "protein_name": "NACHT, LRR and PYD domains-containing protein 3", "gene_name": "Nlrp3", "organism": "Rat", "refseq_name": "NACHT, LRR and PYD domains-containing protein 3", "refseq_ac": [ { "id": "NP_001178571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178571", "type": "external" } ], "gene_names_uniprotkb": "Nlrp3", "gene_names_refseq": "Cias1; Nlrp3", "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 3; 3.6.4.-", "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 3; PYRIN-containing APAF1-like protein 1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; mast cell maturation-associated-inducible protein 1", "tax_id": 10116, "disease": "Muckle-Wells syndrome (Disease Ontology:DOID:0050854); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal dominant nonsyndromic deafness 34 (Disease Ontology:DOID:0080270); CINCA Syndrome (Disease Ontology:DOID:0090029); familial cold autoinflammatory syndrome 1 (Disease Ontology:DOID:0090062); alcoholic hepatitis (Disease Ontology:DOID:12351); urticaria (Disease Ontology:DOID:1555); myocardial infarction (Disease Ontology:DOID:5844); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:287362); (R-RNO-5689901); (R-RNO-844456)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "29393594;38676809;38716981;38720901;38788361;38936540;39892583", "class_list": "", "function": "25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Activation of the Nrf2/ARE signaling pathway ameliorates hyperlipidemia-induced renal tubular epithelial cell injury by inhibiting mtROS-mediated NLRP3 inflammasome activation. Publication Status: Online-Only, [RefSeq, PubMed]; Cystatin C Attenuates Perihematomal Secondary Brain Injury by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage., [RefSeq, PubMed]; Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth. During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes., [RefSeq, PubMed]; Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis. In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis. Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. ATP released from necrotic cells triggers activation of NLRP3 inflammasome through P2RX7 signaling leading to neutrophil adhesion to the vascular endothelium close to the injury site (By similarity). Under resting conditions, ADP-bound NLRP3 is autoinhibited (By similarity). NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc. Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex. Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P). Shows ATPase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0009595 detection of biotic stimulus;GO:0044546 NLRP3 inflammasome complex assembly;GO:2000321 positive regulation of T-helper 17 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D4A523-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFC9-1", "uniprot_id": [ { "id": "NID2_RAT", "url": "https://www.uniprot.org/uniprot/B5DFC9", "type": "external" } ], "mass": 152976.0, "length": 1396, "protein_name": "Nidogen-2", "gene_name": "Nid2", "organism": "Rat", "refseq_name": "nidogen-2 precursor", "refseq_ac": [ { "id": "NP_001012005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012005", "type": "external" } ], "gene_names_uniprotkb": "Nid2", "gene_names_refseq": "NID-2; Nid2", "protein_names_uniprotkb": "Nidogen-2; NID-2", "protein_names_refseq": "nidogen 2 (osteonidogen); nidogen-2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:302248); (R-RNO-3000157)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16607619;24090084", "class_list": "", "function": "Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that nidogen-2 could play an important role during embryogenesis, decidualization, and implantation in the endometrium of uterus., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5M812", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B5DFC9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15473-1", "uniprot_id": [ { "id": "IBP3_RAT", "url": "https://www.uniprot.org/uniprot/P15473", "type": "external" } ], "mass": 31680.0, "length": 292, "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "Igfbp3", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 3 precursor", "refseq_ac": [ { "id": "NP_036720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036720", "type": "external" } ], "gene_names_uniprotkb": "Igfbp3; Igfbp-3", "gene_names_refseq": "IGF-BP3; Igfbp3", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3", "protein_names_refseq": "IBP-3; IGF-binding protein 3; IGFBP-3; insulin-like growth factor-binding protein (IGF-BP3); insulin-like growth factor-binding protein 3 precursor", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); small cell carcinoma (Disease Ontology:DOID:0050685); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); myelodysplastic syndrome (Disease Ontology:DOID:0050908); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); prostate cancer (Disease Ontology:DOID:10283); tonsillitis (Disease Ontology:DOID:10456); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); beta thalassemia (Disease Ontology:DOID:12241); alcoholic hepatitis (Disease Ontology:DOID:12351); leukemia (Disease Ontology:DOID:1240); acoustic neuroma (Disease Ontology:DOID:12689); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); cholestasis (Disease Ontology:DOID:13580); Down syndrome (Disease Ontology:DOID:14250); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); ichthyosis (Disease Ontology:DOID:1697); status epilepticus (Disease Ontology:DOID:1824); McCune Albright syndrome (Disease Ontology:DOID:1858); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Turner syndrome (Disease Ontology:DOID:3491); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); urinary system cancer (Disease Ontology:DOID:3996); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolysis bullosa dystrophica (Disease Ontology:DOID:4959); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); ankylosing spondylitis (Disease Ontology:DOID:7147); chronic kidney disease (Disease Ontology:DOID:784); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); Barrett's esophagus (Disease Ontology:DOID:9206); ornithine carbamoyltransferase deficiency (Disease Ontology:DOID:9271); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24484); (R-RNO-381426); (R-RNO-6803211); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "1689154;2443135;2480123;2480787;27439004;30659610;3190697;34284540;35154570", "class_list": "", "function": "Compound 49b treatment inhibited these retinal changes. In REC cultured in hypoxia, levels of IGFBP-3 were reduced, which were significantly increased by Compound 49b. Publication Status: Online-Only, [RefSeq, PubMed]; Established the molecular roles of IGFBP3, HIF1a, and prolyl hydroxylase domain in connecting oxidative stress with hypoxia and in cellular cardiomyocyte apoptosis under hyperglycemia, [RefSeq, PubMed]; MiR-125a-5p silencing inhibits cerebral ischemia-induced injury through targeting IGFBP3., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade. In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis., [UniProtKB, UniProtKB]; Upregulated IGFBP3 with Aging Is Involved in Modulating Apoptosis, Oxidative Stress, and Fibrosis: A Target of Age-Related Erectile Dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 69, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0001968 fibronectin binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0042567 insulin-like growth factor ternary complex;GO:0000792 heterochromatin;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0040008 regulation of growth;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P15473-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97711-1", "uniprot_id": [ { "id": "GRK6_RAT", "url": "https://www.uniprot.org/uniprot/P97711", "type": "external" } ], "mass": 65963.0, "length": 576, "protein_name": "G protein-coupled receptor kinase 6", "gene_name": "Grk6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Grk6; Gprk6", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-coupled receptor kinase 6; 2.7.11.16; G protein-coupled receptor kinase GRK6", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); opiate dependence (Disease Ontology:DOID:2559); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (R-RNO-418555)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9387888;9826657", "class_list": "", "function": "Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor: LRP6 during Wnt signaling (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004703 G protein-coupled receptor kinase activity;GO:0047696 beta-adrenergic receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0071222 cellular response to lipopolysaccharide;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction;GO:0002029 desensitization of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97711-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70606-1", "uniprot_id": [ { "id": "KCNN1_RAT", "url": "https://www.uniprot.org/uniprot/P70606", "type": "external" } ], "mass": 59215.0, "length": 536, "protein_name": "Small conductance calcium-activated potassium channel protein 1", "gene_name": "Kcnn1", "organism": "Rat", "refseq_name": "small conductance calcium-activated potassium channel protein 1", "refseq_ac": [ { "id": "NP_062186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062186", "type": "external" } ], "gene_names_uniprotkb": "Kcnn1; Sk1", "gene_names_refseq": "KCa2.1; Kcnn1; SK1; SKCa1", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 1; KCa2.1; SK1; SKCa 1; SKCa1", "protein_names_refseq": "potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like; small conductance calcium-activated potassium channel protein 1", "tax_id": 10116, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); asphyxiating thoracic dystrophy 3 (Disease Ontology:DOID:0110087); VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (rno:54261); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14761961;16641100;22647293;24096910;24841382;31001092;31276786;8781233;9380751", "class_list": "", "function": "RSK1 appears to act as chaperone for rSK2 channels and expression of rSK1 may control the level of functional SK current in rat neurons. Publication Status: Online-Only, [RefSeq, PubMed]; RSK1 subunit is synthesized in cells but does not form functional homomeric channels, [RefSeq, PubMed]; SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking., [RefSeq, PubMed]; Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function., [RefSeq, PubMed]; Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (By similarity). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (By similarity). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results indicate that ADSC-derived exosomes ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization., [RefSeq, PubMed]; This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044877 protein-containing complex binding;GO:0016286 small conductance calcium-activated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0030018 Z disc", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P70606-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02955-1", "uniprot_id": [ { "id": "IL1R1_RAT", "url": "https://www.uniprot.org/uniprot/Q02955", "type": "external" } ], "mass": 66759.0, "length": 576, "protein_name": "Interleukin-1 receptor type 1", "gene_name": "Il1r1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il1r1; Il1ra", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-1 receptor type 1; 3.2.2.6; CD121 antigen-like family member A; IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; p80", "protein_names_refseq": "", "tax_id": 10116, "disease": "chronic recurrent multifocal osteomyelitis (Disease Ontology:DOID:0060645); COVID-19 (Disease Ontology:DOID:0080600); cholesteatoma of middle ear (Disease Ontology:DOID:10964); pulpitis (Disease Ontology:DOID:11121); severe acute respiratory syndrome (Disease Ontology:DOID:2945); systemic scleroderma (Disease Ontology:DOID:418); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-RNO-9020702)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7684399", "class_list": "", "function": "Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0002020 protease binding;GO:0019966 interleukin-1 binding;GO:0004908 interleukin-1 receptor activity;GO:0004909 interleukin-1, type I, activating receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0071559 response to transforming growth factor beta;GO:2000661 positive regulation of interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q02955-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13195-1", "uniprot_id": [ { "id": "HEM1_RAT", "url": "https://www.uniprot.org/uniprot/P13195", "type": "external" } ], "mass": 71021.0, "length": 642, "protein_name": "5-aminolevulinate synthase, non-specific, mitochondrial", "gene_name": "Alas1", "organism": "Rat", "refseq_name": "5-aminolevulinate synthase, non-specific, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077810", "type": "external" } ], "gene_names_uniprotkb": "Alas1", "gene_names_refseq": "ALA-S; ALAS-H; ALAS-N; ALAS; Alas1", "protein_names_uniprotkb": "5-aminolevulinate synthase, non-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 1; ALAS-H; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1", "protein_names_refseq": "5-aminolevulinate synthase 1; 5-aminolevulinate synthase, non-specific, mitochondrial precursor; 5-aminolevulinate synthase, non-specific, mitochondrial; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1", "tax_id": 10116, "disease": "porphyria (Disease Ontology:DOID:13268); erythropoietic protoporphyria (Disease Ontology:DOID:13270); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:65155); (R-RNO-189451); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26102301;29393594;3182776;3356687", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; REV-ERBalpha has a role in circadian oscillation in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P782", "ec_number_list": [ { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels;GO:0051591 response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13195-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z902-1", "uniprot_id": [ { "id": "FBXW7_RAT", "url": "https://www.uniprot.org/uniprot/D3Z902", "type": "external" } ], "mass": 80367.0, "length": 713, "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "Fbxw7", "organism": "Rat", "refseq_name": "F-box/WD repeat-containing protein 7", "refseq_ac": [ { "id": "NP_001406457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406457", "type": "external" } ], "gene_names_uniprotkb": "Fbxw7; LOC100360914", "gene_names_refseq": "Fbw7; Fbxw7", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 7", "protein_names_refseq": "F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; F-box and WD-40 domain protein 7; F-box/WD repeat-containing protein 7", "tax_id": 10116, "disease": "developmental delay, hypotonia, and impaired language (Disease Ontology:DOID:0070420)", "pathway": " (rno:100360914); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "27458189;31257502;32707070;36427396;36660176", "class_list": "", "function": "Calpain-mediated cleavage of Fbxw7 during excitotoxicity., [RefSeq, PubMed]; FBXW7 alleviates hyperglycemia-induced endothelial oxidative stress injury via ROS and PARP inhibition., [RefSeq, PubMed]; Fbw7 participates in oxidative stress-induced myocardial cell injury via interacting with Mcl1., [RefSeq, PubMed]; LncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, MLST8, RICTOR and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (By similarity). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (By similarity). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010992 ubiquitin recycling;GO:0001570 vasculogenesis;GO:0006281 DNA repair;GO:0007219 Notch signaling pathway;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3Z902-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRC4-1", "uniprot_id": [ { "id": "GPC5C_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRC4", "type": "external" } ], "mass": 48449.0, "length": 441, "protein_name": "G protein-coupled receptor family C group 5 member C", "gene_name": "Gprc5c", "organism": "Rat", "refseq_name": "G-protein coupled receptor family C group 5 member C isoform 1 precursor", "refseq_ac": [ { "id": "NP_001426642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426642", "type": "external" } ], "gene_names_uniprotkb": "Gprc5c", "gene_names_refseq": "Gprc5c", "protein_names_uniprotkb": "G protein-coupled receptor family C group 5 member C", "protein_names_refseq": "G-protein coupled receptor family C group 5 member C isoform 1 precursor; G-protein coupled receptor family C group 5 member C", "tax_id": 10116, "disease": "", "pathway": " (rno:287805)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "This retinoic acid-inducible G protein-coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0070062 extracellular exosome;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KRC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88658-1", "uniprot_id": [ { "id": "KIF1B_RAT", "url": "https://www.uniprot.org/uniprot/O88658", "type": "external" } ], "mass": 204170.0, "length": 1816, "protein_name": "Kinesin-like protein KIF1B", "gene_name": "Kif1b; Pgd", "organism": "Rat", "refseq_name": "kinesin-like protein KIF1B", "refseq_ac": [ { "id": "NP_476548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476548", "type": "external" } ], "gene_names_uniprotkb": "Kif1b; Pgd; Kif1b; Pgd", "gene_names_refseq": "Kif1b", "protein_names_uniprotkb": "Kinesin-like protein KIF1B; 5.6.1.3", "protein_names_refseq": "kinesin-family protein KIF1Bbeta3; kinesin-like protein KIF1B", "tax_id": 10116, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); Charcot-Marie-Tooth disease type 2A1 (Disease Ontology:DOID:0110154); ovary epithelial cancer (Disease Ontology:DOID:2152); multiple sclerosis (Disease Ontology:DOID:2377); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); hepatocellular carcinoma (Disease Ontology:DOID:684); neuroblastoma (Disease Ontology:DOID:769); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:117548); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12204119;15086790;22673903;9808286", "class_list": "", "function": "Has a plus-end-directed microtubule motor activity and functions as a motor for anterograde synaptic vesicle transport along axonal microtubules from the cell body to the presynapse in neuronal cells., [UniProtKB, PubMed]; Has a plus-end-directed microtubule motor activity and functions as a motor for the translocation of lysosomes from perinuclear regions to the cell periphery., [UniProtKB, PubMed]; Has a plus-end-directed microtubule motor activity and functions as a motor for transport of vesicles and organelles along microtubules., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZK86;Q65Z71;Q8R524", "ec_number_list": [ { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019900 kinase binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:1904647 response to rotenone;GO:1990778 protein localization to cell periphery;GO:0007274 neuromuscular synaptic transmission;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88658-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60570-1", "uniprot_id": [ { "id": "PANX1_RAT", "url": "https://www.uniprot.org/uniprot/P60570", "type": "external" } ], "mass": 48073.0, "length": 426, "protein_name": "Pannexin-1", "gene_name": "Panx1", "organism": "Rat", "refseq_name": "pannexin-1 isoform a", "refseq_ac": [ { "id": "NP_955429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955429", "type": "external" } ], "gene_names_uniprotkb": "Panx1; Px1", "gene_names_refseq": "Panx1; px1", "protein_names_uniprotkb": "Pannexin-1", "protein_names_refseq": "pannexin-1 isoform a; pannexin-1", "tax_id": 10116, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:315435); (R-RNO-112303); (R-RNO-844456)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "14597722;16616526;17036048;18649184;34768835;34808525;35029007;38338895", "class_list": "", "function": "Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats. Publication Status: Online-Only, [RefSeq, PubMed]; During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells., [UniProtKB, UniProtKB]; Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (By similarity). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia., [RefSeq, PubMed]; Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain. Publication Status: Online-Only, [RefSeq, PubMed]; Pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation., [RefSeq, PubMed]; Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons, [RefSeq, PubMed]; Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet., [RefSeq, PubMed]; The different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions., [RefSeq, PubMed]; The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032059 bleb;GO:0005921 gap junction", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0098656 monoatomic anion transmembrane transport;GO:0002931 response to ischemia;GO:0007267 cell-cell signaling;GO:0006816 calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P60570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26896-1", "uniprot_id": [ { "id": "IL2RB_RAT", "url": "https://www.uniprot.org/uniprot/P26896", "type": "external" } ], "mass": 60657.0, "length": 537, "protein_name": "Interleukin-2 receptor subunit beta", "gene_name": "Il2rb", "organism": "Rat", "refseq_name": "interleukin-2 receptor subunit beta precursor", "refseq_ac": [ { "id": "NP_037327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037327", "type": "external" } ], "gene_names_uniprotkb": "Il2rb", "gene_names_refseq": "IL2RBC; Il2rb", "protein_names_uniprotkb": "Interleukin-2 receptor subunit beta; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; p70-75", "protein_names_refseq": "IL-2R subunit beta; IL-2RB; P70-75; high affinity IL-2 receptor subunit beta; interleukin 2 receptor, beta chain; interleukin-2 receptor subunit beta precursor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); immunodeficiency 63 (Disease Ontology:DOID:0111997); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); lactic acidosis (Disease Ontology:DOID:3650); myasthenia gravis (Disease Ontology:DOID:437); visceral leishmaniasis (Disease Ontology:DOID:9146)", "pathway": " (rno:25746); (R-RNO-5673001); (R-RNO-8983432); (R-RNO-9020558); (R-RNO-912526)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "17675186;1889461", "class_list": "", "function": "Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0004911 interleukin-2 receptor activity;GO:0019976 interleukin-2 binding;GO:0042010 interleukin-15 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005893 interleukin-2 receptor complex;GO:1905543 interleukin-15 receptor complex", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0050766 positive regulation of phagocytosis;GO:0019221 cytokine-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26896-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35234-1", "uniprot_id": [ { "id": "PTN5_RAT", "url": "https://www.uniprot.org/uniprot/P35234", "type": "external" } ], "mass": 42366.0, "length": 369, "protein_name": "Tyrosine-protein phosphatase non-receptor type 5", "gene_name": "Ptpn5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptpn5", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 5; 3.1.3.48; Neural-specific protein-tyrosine phosphatase; STEP; Striatum-enriched protein-tyrosine phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:29644)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1714595", "class_list": "", "function": "May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35234-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O19477-1", "uniprot_id": [ { "id": "HMR1_RAT", "url": "https://www.uniprot.org/uniprot/O19477", "type": "external" } ], "mass": 39571.0, "length": 343, "protein_name": "Major histocompatibility complex class I-related protein 1", "gene_name": "Mr1", "organism": "Rat", "refseq_name": "major histocompatibility complex class I-related protein 1 precursor", "refseq_ac": [ { "id": "NP_001094105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094105", "type": "external" } ], "gene_names_uniprotkb": "Mr1; Hlals", "gene_names_refseq": "Hlals; Mr1", "protein_names_uniprotkb": "Major histocompatibility complex class I-related protein 1; MHC class I-related protein 1", "protein_names_refseq": "MHC class I-like sequence; MHC class I-related gene protein; MHC class I-related protein 1; histocompatibility-2 complex class 1-like sequence; major histocompatibility complex class I-related gene protein; major histocompatibility complex class I-related protein 1 precursor; major histocompatibility complex class I-related protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25119)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12137932;9553154", "class_list": "", "function": "Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells. During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora. Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types. May present tumor-enriched pyridoxal and pyridoxal 5'-phosphate antigens, enabling preferential recognition of cancer cells. Presents nucleobase carbonyl adducts generated during oxidative stress. Captures M3Ade, a nucleobase adduct composed of one adenine modified by a malondialdehyde trimer, for recognition by MR1-restricted T cell clones expressing a polyclonal TCR repertoire., [UniProtKB, UniProtKB]; Downregulation in microglia while differentiating into ramified cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0042608 T cell receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O19477-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28492-1", "uniprot_id": [ { "id": "GLSL_RAT", "url": "https://www.uniprot.org/uniprot/P28492", "type": "external" } ], "mass": 66248.0, "length": 602, "protein_name": "Glutaminase liver isoform, mitochondrial", "gene_name": "Gls2", "organism": "Rat", "refseq_name": "glutaminase liver isoform, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001257715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257715", "type": "external" } ], "gene_names_uniprotkb": "Gls2; Ga", "gene_names_refseq": "Ga; Gls2", "protein_names_uniprotkb": "Glutaminase liver isoform, mitochondrial; 3.5.1.2; GLS; L-glutaminase; L-glutamine amidohydrolase", "protein_names_refseq": "GLS; L-glutaminase; L-glutamine amidohydrolase; glutaminase 2 (liver, mitochondrial); glutaminase liver isoform, mitochondrial isoform 1; liver mitochondrial glutaminase", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 71 (Disease Ontology:DOID:0112207)", "pathway": " (rno:192268); (R-RNO-210500); (R-RNO-5628897); (R-RNO-8964539)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "2191954;22679499;25065305;25297978;34111670;9164856", "class_list": "", "function": "GABAergic neurons and astrocytes express Gls and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons, [RefSeq, PubMed]; In animals with chronic hepatitis; hyperbaric oxygenation restricted the stimulating effect of hepatic resection on phosphate-dependent glutaminase activity., [RefSeq, PubMed]; MiR-190a-5p regulates cardiomyocytes response to ferroptosis via directly targeting GLS2., [RefSeq, PubMed]; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation., [UniProtKB, UniProtKB]; Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHS6;Q5FVU0;Q64606", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0072593 reactive oxygen species metabolic process;GO:0006537 glutamate biosynthetic process;GO:0006543 L-glutamine catabolic process;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28492-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43303-1", "uniprot_id": [ { "id": "IL1R2_RAT", "url": "https://www.uniprot.org/uniprot/P43303", "type": "external" } ], "mass": 46353.0, "length": 416, "protein_name": "Interleukin-1 receptor type 2", "gene_name": "Il1r2", "organism": "Rat", "refseq_name": "interleukin-1 receptor type 2 precursor", "refseq_ac": [ { "id": "NP_446405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446405", "type": "external" } ], "gene_names_uniprotkb": "Il1r2; Il-1r2; Il1rb", "gene_names_refseq": "Il1r2", "protein_names_uniprotkb": "Interleukin-1 receptor type 2; CD121 antigen-like family member B; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; Interleukin-1 receptor beta; Interleukin-1 receptor type II", "protein_names_refseq": "CD121 antigen-like family member B; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; interleukin-1 receptor beta; interleukin-1 receptor type 2 precursor; interleukin-1 receptor type II", "tax_id": 10116, "disease": "organ system cancer (Disease Ontology:DOID:0050686); lung cancer (Disease Ontology:DOID:1324); aggressive periodontitis (Disease Ontology:DOID:1474); lung adenocarcinoma (Disease Ontology:DOID:3910); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041)", "pathway": " (rno:117022); (R-RNO-9020702)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "34575945;35087030;7524717", "class_list": "", "function": "Adipose-Derived Extract Suppresses IL-1beta-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJ99", "ec_number_list": [], "go_molecular_function": "GO:0019966 interleukin-1 binding;GO:0004908 interleukin-1 receptor activity;GO:0004910 interleukin-1, type II, blocking receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045323 interleukin-1 receptor complex", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:1900016 negative regulation of cytokine production involved in inflammatory response;GO:0010955 negative regulation of protein processing;GO:0032690 negative regulation of interleukin-1 alpha production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P43303-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06866-1", "uniprot_id": [ { "id": "HPT_RAT", "url": "https://www.uniprot.org/uniprot/P06866", "type": "external" } ], "mass": 38563.0, "length": 347, "protein_name": "Haptoglobin", "gene_name": "Hp", "organism": "Rat", "refseq_name": "haptoglobin precursor", "refseq_ac": [ { "id": "NP_036714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036714", "type": "external" } ], "gene_names_uniprotkb": "Hp; Ba1-647", "gene_names_refseq": "Ba1-647; Hp", "protein_names_uniprotkb": "Haptoglobin; Liver regeneration-related protein LRRG173", "protein_names_refseq": "haptoglobin precursor; liver regeneration-related protein LRRG173; zonulin", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); hepatocellular adenoma (Disease Ontology:DOID:0050868); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); alpha thalassemia (Disease Ontology:DOID:1099); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); gout (Disease Ontology:DOID:13189); lung cancer (Disease Ontology:DOID:1324); Kawasaki disease (Disease Ontology:DOID:13378); cholestasis (Disease Ontology:DOID:13580); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); hyperglycemia (Disease Ontology:DOID:4195); liver cirrhosis (Disease Ontology:DOID:5082); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24464); (R-RNO-2168880); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21454685;2320005;6204979;6863267;975782", "class_list": "", "function": "As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB4;Q7TP23", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0016209 antioxidant activity;GO:0030492 hemoglobin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0072562 blood microparticle;GO:0031838 haptoglobin-hemoglobin complex;GO:0005576 extracellular region", "go_biological_process": "GO:2000296 negative regulation of hydrogen peroxide catabolic process;GO:0001889 liver development;GO:0006954 inflammatory response;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P06866-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35760-1", "uniprot_id": [ { "id": "IDI1_RAT", "url": "https://www.uniprot.org/uniprot/O35760", "type": "external" } ], "mass": 26396.0, "length": 227, "protein_name": "Isopentenyl-diphosphate Delta-isomerase 1", "gene_name": "Idi1", "organism": "Rat", "refseq_name": "isopentenyl-diphosphate Delta-isomerase 1", "refseq_ac": [ { "id": "NP_445991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445991", "type": "external" } ], "gene_names_uniprotkb": "Idi1", "gene_names_refseq": "Idi1", "protein_names_uniprotkb": "Isopentenyl-diphosphate Delta-isomerase 1; 5.3.3.2; IPP isomerase 1; IPPI1; Isopentenyl pyrophosphate isomerase 1", "protein_names_refseq": "IPP isomerase 1; IPPI1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate Delta-isomerase 1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:89784); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9228075", "class_list": "", "function": "Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVT3", "ec_number_list": [ { "id": "5.3.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.2", "type": "external" } ], "go_molecular_function": "GO:0004452 isopentenyl-diphosphate delta-isomerase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0009240 isopentenyl diphosphate biosynthetic process;GO:0050992 dimethylallyl diphosphate biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0035634 response to stilbenoid;GO:0033386 geranylgeranyl diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35760-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LV46-1", "uniprot_id": [ { "id": "I23O2_RAT", "url": "https://www.uniprot.org/uniprot/F1LV46", "type": "external" } ], "mass": 45236.0, "length": 405, "protein_name": "Indoleamine 2,3-dioxygenase 2", "gene_name": "Ido2", "organism": "Rat", "refseq_name": "indoleamine 2,3-dioxygenase 2", "refseq_ac": [ { "id": "NP_001406603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406603", "type": "external" } ], "gene_names_uniprotkb": "Ido2; Indol1", "gene_names_refseq": "IDO-2; Ido2; Indol1", "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 2; 1.13.11.-; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1", "protein_names_refseq": "indoleamine 2,3-dioxygenase 2; indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; indoleamine-pyrrole 2,3-dioxygenase-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:681319); (R-RNO-71240)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21841011", "class_list": "", "function": "Catalyzes the first and rate limiting step of the catabolism of tryptophan along the kynurenine pathway. Involved in immune regulation., [UniProtKB, UniProtKB]; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation., [UniProtKB, UniProtKB]; We conclude that IDO is an enzyme active primarily in brown fat surrounding the thoracic aorta and depresses aortic contractility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" }, { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity;GO:0033754 indoleamine 2,3-dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0002376 immune system process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LV46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7C5-1", "uniprot_id": [ { "id": "LRRT4_RAT", "url": "https://www.uniprot.org/uniprot/B4F7C5", "type": "external" } ], "mass": 67170.0, "length": 590, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 4", "gene_name": "Lrrtm4", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 4 precursor", "refseq_ac": [ { "id": "NP_001128218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128218", "type": "external" } ], "gene_names_uniprotkb": "Lrrtm4", "gene_names_refseq": "Lrrtm4; RGD1560707", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 4", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 4 precursor; leucine-rich repeat transmembrane neuronal protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:500219); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19285470;22632720", "class_list": "", "function": "May play a role in the development and maintenance of the nervous system (By similarity). Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043395 heparan sulfate proteoglycan binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050808 synapse organization;GO:0051965 positive regulation of synapse assembly;GO:0051963 regulation of synapse assembly;GO:0097113 AMPA glutamate receptor clustering;GO:0072578 neurotransmitter-gated ion channel clustering", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B4F7C5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQX2-1", "uniprot_id": [ { "id": "NILR1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQX2", "type": "external" } ], "mass": 61258.0, "length": 547, "protein_name": "Neutrophil immunoglobulin-like receptor 1", "gene_name": "Lilrb2; Nilr1", "organism": "Rat", "refseq_name": "neutrophil immunoglobulin-like receptor 1", "refseq_ac": [ { "id": "NP_113901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113901", "type": "external" } ], "gene_names_uniprotkb": "Lilrb2; Nilr1; Nilr1", "gene_names_refseq": "Lilrb2; Lilrb3; NILR-1; Nilr1; Pirb", "protein_names_uniprotkb": "Neutrophil immunoglobulin-like receptor 1", "protein_names_refseq": "leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; neutrophil immunoglobulin-like receptor 1; paired Ig-like receptor B; type 1 one-pass transmembrane Ig-like receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:65146)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10382763;24461182;26821234;27966582;28669876", "class_list": "", "function": "Electroacupuncture (EA) enhances rehabilitation against stroke by regulating epigenetic changes to directly act on its targets, such as the miR-181b/PirB/RhoA/GAP43 axis, which is a novel mechanism of EA therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Estradiol protects oligodendrocyte precursor cells from hyperoxiainduced apoptosis, predominantly through the downregulation of PirB., [RefSeq, PubMed]; In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing., [RefSeq, PubMed]; PirB might be involved in hypoxic-ischemic brain damage (HIBD) through a Rho-ROCK-dependent mechanism., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2J8C0", "ec_number_list": [], "go_molecular_function": "GO:0032396 inhibitory MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZQX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63074-1", "uniprot_id": [ { "id": "IF4E_RAT", "url": "https://www.uniprot.org/uniprot/P63074", "type": "external" } ], "mass": 25053.0, "length": 217, "protein_name": "Eukaryotic translation initiation factor 4E", "gene_name": "Eif4e", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 4E", "refseq_ac": [ { "id": "NP_446426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446426", "type": "external" } ], "gene_names_uniprotkb": "Eif4e", "gene_names_refseq": "Eif4e", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; eIF4E; mRNA cap-binding protein", "protein_names_refseq": "eIF-4E; eIF-4F 25 kDa subunit; eukaryotic initiation factor 4E; eukaryotic translation initiation factor 4E; mRNA cap-binding protein", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); candidiasis (Disease Ontology:DOID:1508); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:117045); (R-RNO-156827); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-166208); (R-RNO-429947); (R-RNO-72649); (R-RNO-72662); (R-RNO-72702)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "1545805;16817885;27065075;31877332;33864263;34638676;37175950;37442236;7939721;8558852", "class_list": "", "function": "Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing (By similarity). Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:7939721). Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary (By similarity). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:8558852). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap. Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (By similarity). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (PubMed:8558852). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1. Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA (By similarity). Promotes the nuclear export of MDM2 mRNA (By similarity). Also promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Differential Association of 4E-BP2-Interacting Proteins Is Related to Selective Delayed Neuronal Death after Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3beta pathway., [RefSeq, PubMed]; The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons., [RefSeq, PubMed]; Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20415", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0098808 mRNA cap binding;GO:0031370 eukaryotic initiation factor 4G binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation;GO:0045665 negative regulation of neuron differentiation;GO:0045931 positive regulation of mitotic cell cycle;GO:0030324 lung development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63074-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RAS4-1", "uniprot_id": [ { "id": "IGS21_RAT", "url": "https://www.uniprot.org/uniprot/M0RAS4", "type": "external" } ], "mass": 52044.0, "length": 468, "protein_name": "Immunoglobulin superfamily member 21", "gene_name": "Igsf21", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 21 precursor", "refseq_ac": [ { "id": "NP_001258383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258383", "type": "external" } ], "gene_names_uniprotkb": "Igsf21", "gene_names_refseq": "Igsf21; RGD1310117", "protein_names_uniprotkb": "Immunoglobulin superfamily member 21; IgSF21", "protein_names_refseq": "immunoglobulin superfamily member 21 precursor; immunoglobulin superfamily member 21", "tax_id": 10116, "disease": "", "pathway": " (rno:298591)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28864826", "class_list": "", "function": "Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0042734 presynaptic membrane;GO:0060077 inhibitory synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "M0RAS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F777-1", "uniprot_id": [ { "id": "HMGN5_RAT", "url": "https://www.uniprot.org/uniprot/B4F777", "type": "external" } ], "mass": 48605.0, "length": 429, "protein_name": "High mobility group nucleosome-binding domain-containing protein 5", "gene_name": "Hmgn5", "organism": "Rat", "refseq_name": "high mobility group nucleosome-binding domain-containing protein 5", "refseq_ac": [ { "id": "NP_001128178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128178", "type": "external" } ], "gene_names_uniprotkb": "Hmgn5; Hmgn5b; LOC100910616; Nsbp1", "gene_names_refseq": "Hmgn5b; Hmgn5l1; Hmgn5; Nsbp1", "protein_names_uniprotkb": "High mobility group nucleosome-binding domain-containing protein 5; Nucleosome-binding protein 1", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 5-like; high mobility group nucleosome-binding domain-containing protein 5; high-mobility group nucleosome binding domain 5-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:120097335)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19160411", "class_list": "", "function": "Identify NSBP1 as a nucleosome binding protein that modulates the expression of prolactin gene family members most likely by inducing changes in chromatin structure, [RefSeq, PubMed]; Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B4F777-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F785-1", "uniprot_id": [ { "id": "EGFLA_RAT", "url": "https://www.uniprot.org/uniprot/B4F785", "type": "external" } ], "mass": 109670.0, "length": 1005, "protein_name": "Pikachurin", "gene_name": "Egflam", "organism": "Rat", "refseq_name": "pikachurin precursor", "refseq_ac": [ { "id": "NP_001102408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102408", "type": "external" } ], "gene_names_uniprotkb": "Egflam", "gene_names_refseq": "Egflam; RGD1306592", "protein_names_uniprotkb": "Pikachurin; EGF-like, fibronectin type-III and laminin G-like domain-containing protein", "protein_names_refseq": "EGF-like, fibronectin type-III and laminin G-like domain-containing protein; pikachurin precursor; pikachurin", "tax_id": 10116, "disease": "", "pathway": " (rno:365691)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005509 calcium ion binding;GO:0005539 glycosaminoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030198 extracellular matrix organization;GO:0007416 synapse assembly;GO:0010811 positive regulation of cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F785-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7A1-1", "uniprot_id": [ { "id": "LYRM7_RAT", "url": "https://www.uniprot.org/uniprot/B4F7A1", "type": "external" } ], "mass": 12030.0, "length": 104, "protein_name": "Complex III assembly factor LYRM7", "gene_name": "Lyrm7", "organism": "Rat", "refseq_name": "complex III assembly factor LYRM7", "refseq_ac": [ { "id": "NP_001128201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128201", "type": "external" } ], "gene_names_uniprotkb": "Lyrm7; MZM1L", "gene_names_refseq": "Lyrm7", "protein_names_uniprotkb": "Complex III assembly factor LYRM7; LYR motif-containing protein 7", "protein_names_refseq": "LYR motif-containing protein 7; complex III assembly factor LYRM7", "tax_id": 10116, "disease": "mitochondrial complex III deficiency nuclear type 8 (Disease Ontology:DOID:0080117); mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (rno:686506); (R-RNO-9865881)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0045333 cellular respiration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F7A1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEL1-1", "uniprot_id": [ { "id": "KCTD5_RAT", "url": "https://www.uniprot.org/uniprot/B5DEL1", "type": "external" } ], "mass": 26164.0, "length": 234, "protein_name": "BTB/POZ domain-containing protein KCTD5", "gene_name": "Kctd5", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD5", "refseq_ac": [ { "id": "NP_001099238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099238", "type": "external" } ], "gene_names_uniprotkb": "Kctd5", "gene_names_refseq": "Kctd5", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD5", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD5; potassium channel tetramerisation domain containing 5", "tax_id": 10116, "disease": "myoclonic dystonia (Disease Ontology:DOID:0090033)", "pathway": " (rno:287109)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DEL1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF51-1", "uniprot_id": [ { "id": "EMC5_RAT", "url": "https://www.uniprot.org/uniprot/B5DF51", "type": "external" } ], "mass": 14677.0, "length": 131, "protein_name": "ER membrane protein complex subunit 5", "gene_name": "Mmgt1", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 5", "refseq_ac": [ { "id": "NP_001100440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100440", "type": "external" } ], "gene_names_uniprotkb": "Mmgt1; Emc5; Tmem32", "gene_names_refseq": "Mmgt1; RGD1566339; Tmem32", "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Membrane magnesium transporter 1; Transmembrane protein 32", "protein_names_refseq": "ER membrane protein complex subunit 5; transmembrane protein 32", "tax_id": 10116, "disease": "", "pathway": " (rno:302864)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015087 cobalt ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015693 magnesium ion transport;GO:0006812 monoatomic cation transport;GO:0006825 copper ion transport;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DF51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFK3-1", "uniprot_id": [ { "id": "HXD9_RAT", "url": "https://www.uniprot.org/uniprot/B5DFK3", "type": "external" } ], "mass": 35186.0, "length": 343, "protein_name": "Homeobox protein Hox-D9", "gene_name": "Hoxd9", "organism": "Rat", "refseq_name": "homeobox protein Hox-D9", "refseq_ac": [ { "id": "NP_001166940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166940", "type": "external" } ], "gene_names_uniprotkb": "Hoxd9", "gene_names_refseq": "Hoxd9", "protein_names_uniprotkb": "Homeobox protein Hox-D9", "protein_names_refseq": "homeobox Hox-D9; homeobox protein Hox-D9", "tax_id": 10116, "disease": "", "pathway": " (rno:688999)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34288810", "class_list": "", "function": "All-trans-retinoic acid suppresses rat embryo hindlimb bud mesenchymal chondrogenesis by modulating HoxD9 expression., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DFK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8N4-1", "uniprot_id": [ { "id": "KLH20_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8N4", "type": "external" } ], "mass": 67955.0, "length": 609, "protein_name": "Kelch-like protein 20", "gene_name": "Klhl20", "organism": "Rat", "refseq_name": "kelch-like protein 20", "refseq_ac": [ { "id": "NP_001100662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100662", "type": "external" } ], "gene_names_uniprotkb": "Klhl20", "gene_names_refseq": "Klhl20; RGD1309490", "protein_names_uniprotkb": "Kelch-like protein 20", "protein_names_refseq": "kelch-like 20; kelch-like protein 20", "tax_id": 10116, "disease": "", "pathway": " (rno:304920); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21670212", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0019964 type II interferon binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9H7-1", "uniprot_id": [ { "id": "NFAC4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9H7", "type": "external" } ], "mass": 95764.0, "length": 901, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 4", "gene_name": "Nfatc4", "organism": "Rat", "refseq_name": "nuclear factor of activated T-cells, cytoplasmic 4", "refseq_ac": [ { "id": "NP_001100734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100734", "type": "external" } ], "gene_names_uniprotkb": "Nfatc4; Nfat3", "gene_names_refseq": "NF-AT3; NF-ATc4; Nfatc4", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 4; NF-AT3; NF-ATc4; NFATc4; T-cell transcription factor NFAT3", "protein_names_refseq": "T-cell transcription factor NFAT3; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:305897)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11827959;12370307;19026640;19538478;26945895;27155398;29637744;31486013;31789412;32805187;9568714", "class_list": "", "function": "Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:12370307, PubMed:32805187). Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (PubMed:19026640). Binds to and transactivates AGTR2 gene promoter. Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (By similarity). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytes., [RefSeq, PubMed]; Inhibition of calcineurin/NFATc4 signaling attenuates ventilatorinduced lung injury., [RefSeq, PubMed]; Our results show that CaN/NFATc4 pathway were involved in the development of PTSD model, which suggested that the changes of CaN/NFATc4 pathway may be one of the pathological molecular mechanism in the dysfunction of hippocampus in PTSD., [RefSeq, PubMed]; Results suggest a novel mechanism of the transcriptional regulation of LTCC alpha1C by synergistic activities of NFATc4 and myocardin in ET-1-induced cardiomyocyte hypertrophy, [RefSeq, PubMed]; The transcriptional activation of nuclear factor of activated T-cell proteins (NFATs), but not nuclear factor-kappaB, by IL-1beta stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL-1beta-induced expression of both CCL2 and CXCL10., [RefSeq, PubMed]; Tropisetron may have protective effects against high glucose-induced cardiomyocyte hypertrophy. The mechanism responsible for this beneficial effect seems to be, at least in part, blockade of calcineurin/NFATc4 signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K0L1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "D3Z9H7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA76-1", "uniprot_id": [ { "id": "HTRA3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA76", "type": "external" } ], "mass": 49257.0, "length": 459, "protein_name": "Serine protease HTRA3", "gene_name": "Htra3", "organism": "Rat", "refseq_name": "serine protease HTRA3 precursor", "refseq_ac": [ { "id": "NP_001257956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257956", "type": "external" } ], "gene_names_uniprotkb": "Htra3; Prsp", "gene_names_refseq": "Htra3; RGD1308120", "protein_names_uniprotkb": "Serine protease HTRA3; 3.4.21.-; High-temperature requirement factor A3; Pregnancy-related serine protease", "protein_names_refseq": "high-temperature requirement factor A3; pregnancy-related serine protease; probable serine protease HTRA3; serine protease HTRA3 precursor", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:360959)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19415717;35764130", "class_list": "", "function": "High temperature requirement A3 attenuates hypoxia/reoxygenation induced injury in H9C2 cells via suppressing inflammatory responses., [RefSeq, PubMed]; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZLW3", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0030514 negative regulation of BMP signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZA76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDI6-1", "uniprot_id": [ { "id": "MYLIP_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDI6", "type": "external" } ], "mass": 49890.0, "length": 445, "protein_name": "E3 ubiquitin-protein ligase MYLIP", "gene_name": "Mylip", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase MYLIP", "refseq_ac": [ { "id": "NP_001100814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100814", "type": "external" } ], "gene_names_uniprotkb": "Mylip", "gene_names_refseq": "MIR; Mylip", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MYLIP; 2.3.2.27; Idol; Inducible degrader of the LDL-receptor; MIR; Myosin regulatory light chain interacting protein; RING-type E3 ubiquitin transferase MYLIP", "protein_names_refseq": "E3 ubiquitin-protein ligase MYLIP; RING-type E3 ubiquitin transferase MYLIP; idol; inducible degrader of the LDL-receptor", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:306825); (R-RNO-8866427); (R-RNO-983168)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10593918;11162443;23990472;24166456", "class_list": "", "function": "Data indicate that down-regulation of Mylip/Idol using shRNAs abrogated the decrease in VLDLRs induced by Reelin., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR., [UniProtKB, UniProtKB]; LDLR deficiency, hypercholesterolemia and elevated plasma LDL in NS are associated with upregulation of PCSK9 and IDOL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008092 cytoskeletal protein binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0010977 negative regulation of neuron projection development;GO:0042632 cholesterol homeostasis;GO:0010989 negative regulation of low-density lipoprotein particle clearance;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZDI6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE85-1", "uniprot_id": [ { "id": "FRS1L_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE85", "type": "external" } ], "mass": 32457.0, "length": 293, "protein_name": "DOMON domain-containing protein FRRS1L", "gene_name": "Frrs1l", "organism": "Rat", "refseq_name": "DOMON domain-containing protein FRRS1L precursor", "refseq_ac": [ { "id": "NP_001406566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406566", "type": "external" } ], "gene_names_uniprotkb": "Frrs1l", "gene_names_refseq": "Epb4.1l4b; Frrs1l", "protein_names_uniprotkb": "DOMON domain-containing protein FRRS1L; Ferric-chelate reductase 1-like protein", "protein_names_refseq": "DOMON domain-containing protein FRRS1L precursor; DOMON domain-containing protein FRRS1L; erythrocyte protein band 4.1-like 4b; ferric-chelate reductase 1-like protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 37 (Disease Ontology:DOID:0080435)", "pathway": " (rno:366376)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22632720", "class_list": "", "function": "Important modulator of glutamate signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse", "go_biological_process": "GO:1904717 regulation of AMPA glutamate receptor clustering;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:1900449 regulation of glutamate receptor signaling pathway;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZE85-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZGB1-1", "uniprot_id": [ { "id": "NFAT5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZGB1", "type": "external" } ], "mass": 167207.0, "length": 1548, "protein_name": "Nuclear factor of activated T-cells 5", "gene_name": "Nfat5", "organism": "Rat", "refseq_name": "nuclear factor of activated T-cells 5", "refseq_ac": [ { "id": "NP_001100895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100895", "type": "external" } ], "gene_names_uniprotkb": "Nfat5", "gene_names_refseq": "NF-AT5; Nfat5; Nfat; TonEBP", "protein_names_uniprotkb": "Nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor NFAT5", "protein_names_refseq": "T-cell transcription factor NFAT5; nuclear factor of activated T-cells 5, tonicity-responsive; nuclear factor of activated T-cells 5", "tax_id": 10116, "disease": "", "pathway": " (rno:307820)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23233732;29393594;30332317;30664212;31883300;32239388;37380112", "class_list": "", "function": "ANGII increases Annexin-A2 nucleic acid-binding activity and elevates protein levels of the NFAT5 transcription factor in kidneys of hypertensive rats., [RefSeq, PubMed]; LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis., [RefSeq, PubMed]; NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment., [RefSeq, PubMed]; TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats., [RefSeq, PubMed]; The present results suggested that the AngII/TRPC6/NFAT axis may be a crucial signaling pathway in podocytes that is necessary for maintaining the integrity of the glomerular filtration barrier, [RefSeq, PubMed]; Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:23233732). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0070884 regulation of calcineurin-NFAT signaling cascade;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "D3ZGB1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPX4-1", "uniprot_id": [ { "id": "PLXA3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPX4", "type": "external" } ], "mass": 207982.0, "length": 1872, "protein_name": "Plexin-A3", "gene_name": "Plxna3", "organism": "Rat", "refseq_name": "plexin-A3 precursor", "refseq_ac": [ { "id": "NP_001101051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101051", "type": "external" } ], "gene_names_uniprotkb": "Plxna3", "gene_names_refseq": "Plxn4; Plxna3; SEX", "protein_names_uniprotkb": "Plexin-A3", "protein_names_refseq": "Plexin 4, SEX, homolog to the cMet/HGF receptors; plexin-A3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:309280); (R-RNO-399954); (R-RNO-399955); (R-RNO-399956)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23063687;38843836", "class_list": "", "function": "Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)., [UniProtKB]; These results suggest that plexin A3 is expressed in OPCs and immature oligodendrocytes and is involved in OPC migration., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0051495 positive regulation of cytoskeleton organization;GO:0071526 semaphorin-plexin signaling pathway;GO:0021766 hippocampus development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZPX4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47245-1", "uniprot_id": [ { "id": "NRDC_RAT", "url": "https://www.uniprot.org/uniprot/P47245", "type": "external" } ], "mass": 132976.0, "length": 1161, "protein_name": "Nardilysin", "gene_name": "Nrdc", "organism": "Rat", "refseq_name": "nardilysin precursor", "refseq_ac": [ { "id": "NP_037125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037125", "type": "external" } ], "gene_names_uniprotkb": "Nrdc; Nrd1", "gene_names_refseq": "Nrd1; Nrdc", "protein_names_uniprotkb": "Nardilysin; 3.4.24.61; N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase", "protein_names_refseq": "N-arginine dibasic convertase 1; NRD convertase; NRD-C; nardilysin 1 (N-arginine dibasic convertase); nardilysin precursor; nardilysin, N-arginine dibasic convertase 1; nardilysin, N-arginine dibasic convertase, NRD convertase 1", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:25499)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;7819328;8016118;9581555", "class_list": "", "function": "Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35836", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0030425 dendrite", "go_biological_process": "GO:0006508 proteolysis;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:0032760 positive regulation of tumor necrosis factor production;GO:0050772 positive regulation of axonogenesis;GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47245-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSZ3-1", "uniprot_id": [ { "id": "NLK_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSZ3", "type": "external" } ], "mass": 58313.0, "length": 527, "protein_name": "Serine/threonine-protein kinase NLK", "gene_name": "Nlk", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase NLK", "refseq_ac": [ { "id": "NP_001178853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178853", "type": "external" } ], "gene_names_uniprotkb": "Nlk", "gene_names_refseq": "Nlk; RGD1561602", "protein_names_uniprotkb": "Serine/threonine-protein kinase NLK; 2.7.11.24; Nemo-like kinase", "protein_names_refseq": "serine/threonine-protein kinase NLK", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:497961); (R-RNO-4086398)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15870890;23325309;26861724;27577116", "class_list": "", "function": "MiR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression, and inhibition of miR-208a may provide a novel therapeutic target for cardiomyocyte apoptosis, [RefSeq, PubMed]; NLK is decreasingly expressed in an opposite time-course to the development of cerebral vasospasm (CVS) and SAH-induced brain injury Erratum:[Cell Biochem Biophys. 2025 Mar;83(1):1327-1328. doi: 10.1007/s12013-024-01523-2. PMID: 39331357], [RefSeq, PubMed]; Nlk2 gene and Nlkp pseudogene were predicted as retrotransposed Nlk homologs within the rat genome. Nlk2 gene encoded a 480-aa Nlk2 protein with partial deletion within the kinase domain, which was predicted as the dominant negative Nlk homolog., [RefSeq, PubMed]; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner. Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes., [UniProtKB, UniProtKB]; The results showed that NLK was a direct target of mir-208., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZSZ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVP0-1", "uniprot_id": [ { "id": "ISK13_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVP0", "type": "external" } ], "mass": 11415.0, "length": 97, "protein_name": "Serine protease inhibitor Kazal-type 13", "gene_name": "Spink13", "organism": "Rat", "refseq_name": "serine protease inhibitor Kazal-type 13 precursor", "refseq_ac": [ { "id": "NP_001103009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103009", "type": "external" } ], "gene_names_uniprotkb": "Spink13", "gene_names_refseq": "Spink13; Spink5l3", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 13", "protein_names_refseq": "serine peptidase inhibitor, Kazal type 13 (putative); serine protease inhibitor Kazal-type 13 precursor; serine protease inhibitor Kazal-type 13; serine protease inhibitor Kazal-type 5-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:689570)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23430248", "class_list": "", "function": "May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction., [UniProtKB, PubMed]; Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1902225 negative regulation of acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZVP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVU9-1", "uniprot_id": [ { "id": "NAT8L_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVU9", "type": "external" } ], "mass": 32719.0, "length": 299, "protein_name": "N-acetylaspartate synthetase", "gene_name": "Nat8l", "organism": "Rat", "refseq_name": "N-acetylaspartate synthetase", "refseq_ac": [ { "id": "NP_001178610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178610", "type": "external" } ], "gene_names_uniprotkb": "Nat8l", "gene_names_refseq": "Nat8l; RGD1305719", "protein_names_uniprotkb": "N-acetylaspartate synthetase; 2.3.1.17; N-acetyltransferase 8-like protein; NAA synthetase", "protein_names_refseq": "N-acetylaspartate synthetase; N-acetyltransferase 8-like protein; NAA synthetase", "tax_id": 10116, "disease": "", "pathway": " (rno:289727); (R-RNO-8963693)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18621030;20385109;24515258", "class_list": "", "function": "Asp-NAT/NAT8L and NAA immunoreactivities correlate very well in rat brain, with primary localization in neurons, including cortical pyramidal neurons and granule cells of the hippocampus., [RefSeq, PubMed]; Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:18621030). Promotes dopamine uptake by regulating TNF expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The decrease in N-acetylaspartate following severe traumatic brain injury was characterized by profound mitochondrial malfunctioning, dramatic repression of Nat8l gene and concomitant increase in the ASPA gene and protein levels. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.17", "type": "external" } ], "go_molecular_function": "GO:0017188 L-aspartate N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission;GO:0006083 acetate metabolic process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZVU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVV1-1", "uniprot_id": [ { "id": "KHDC3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVV1", "type": "external" } ], "mass": 47179.0, "length": 434, "protein_name": "KH domain-containing protein 3", "gene_name": "Khdc3", "organism": "Rat", "refseq_name": "KH domain-containing protein 3", "refseq_ac": [ { "id": "NP_001100307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100307", "type": "external" } ], "gene_names_uniprotkb": "Khdc3; Ecat1", "gene_names_refseq": "Ecat1; Khdc3; RGD1311617", "protein_names_uniprotkb": "KH domain-containing protein 3; Protein Filia", "protein_names_refseq": "ES cell associated transcript 1; ES cell-associated transcript 1 protein; KH domain-containing protein 3; protein Filia", "tax_id": 10116, "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590)", "pathway": " (rno:300826)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17913455", "class_list": "", "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. KHDC3 ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Regulates homologous recombination-mediated DNA repair via recruitment of RAD51 to sites of DNA double-strand breaks, and sustainment of PARP1 activity, which in turn modulates downstream ATM or ATR activation. Activation of ATM or ATR in response to DNA double-strand breaks may be cell-type specific. Its role in DNA double-strand break repair is independent of its role in restarting stalled replication forks. Promotes neural stem cell neurogenesis and neuronal differentiation in the hippocampus. May regulate normal development of learning, memory and anxiety. Capable of binding RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007015 actin filament organization;GO:0043066 negative regulation of apoptotic process;GO:0090307 mitotic spindle assembly;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZVV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWE7-1", "uniprot_id": [ { "id": "HORM1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWE7", "type": "external" } ], "mass": 44885.0, "length": 392, "protein_name": "HORMA domain-containing protein 1", "gene_name": "Hormad1", "organism": "Rat", "refseq_name": "HORMA domain-containing protein 1", "refseq_ac": [ { "id": "NP_001102419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102419", "type": "external" } ], "gene_names_uniprotkb": "Hormad1", "gene_names_refseq": "Hormad1; RGD1564960", "protein_names_uniprotkb": "HORMA domain-containing protein 1", "protein_names_refseq": "HORMA domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:365868)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZZR2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0060629 regulation of homologous chromosome segregation;GO:0007283 spermatogenesis;GO:0007130 synaptonemal complex assembly;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZWE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXW3-1", "uniprot_id": [ { "id": "FSBP_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXW3", "type": "external" } ], "mass": 34220.0, "length": 298, "protein_name": "Fibrinogen silencer-binding protein", "gene_name": "Fsbp; Rad54b", "organism": "Rat", "refseq_name": "fibrinogen silencer-binding protein", "refseq_ac": [ { "id": "NP_001387886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001387886", "type": "external" } ], "gene_names_uniprotkb": "Fsbp; Rad54b; Fsbp; Rad54b", "gene_names_refseq": "Fsbp", "protein_names_uniprotkb": "Fibrinogen silencer-binding protein", "protein_names_refseq": "fibrinogen silencer-binding protein-like; fibrinogen silencer-binding protein", "tax_id": 10116, "disease": "non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:102550523); (rno:313063)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20531236", "class_list": "", "function": "Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0030674 protein-macromolecule adaptor activity;GO:0004386 helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0009410 response to xenobiotic stimulus;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZXW3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYR1-1", "uniprot_id": [ { "id": "FCHO2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYR1", "type": "external" } ], "mass": 88712.0, "length": 809, "protein_name": "F-BAR domain only protein 2", "gene_name": "Fcho2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fcho2", "gene_names_refseq": "", "protein_names_uniprotkb": "F-BAR domain only protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": " (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21762413;22673903", "class_list": "", "function": "Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0042802 identical protein binding;GO:0001786 phosphatidylserine binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045202 synapse;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0010324 membrane invagination;GO:0072659 protein localization to plasma membrane;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZYR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36373-1", "uniprot_id": [ { "id": "KLK7_RAT", "url": "https://www.uniprot.org/uniprot/P36373", "type": "external" } ], "mass": 28972.0, "length": 261, "protein_name": "Glandular kallikrein-7, submandibular/renal", "gene_name": "Klk7", "organism": "Rat", "refseq_name": "kallikrein 1 precursor", "refseq_ac": [ { "id": "NP_036725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036725", "type": "external" } ], "gene_names_uniprotkb": "Klk7; Klk-7", "gene_names_refseq": "KALA; Kal; Klk1c7; Klk1l; Klk1; Klk5; Klk7; Klna3; RATKALA; RGK-7; RSKG-7", "protein_names_uniprotkb": "Glandular kallikrein-7, submandibular/renal; 3.4.21.35; Esterase B; Kallikrein-related protein K1; Proteinase A; RSKG-7; Tissue kallikrein; rGK-7", "protein_names_refseq": "Kallikrein 1, renal/pancreas/salivary; esterase B; glandular kallikrein-7, submandibular/renal; kallikrein 1 precursor; kallikrein 1-like peptidase; kallikrein 1-related peptidase C7; kallikrein 5; kallikrein 7; kallikrein a3; kallikrein-related protein K1; proteinase A; renal kallikrein; tissue kallikrein", "tax_id": 10116, "disease": "", "pathway": " (rno:24523); (rno:292852)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19816038;2183721;2194829;26252163;2849988;31299611;33355364;3482210", "class_list": "", "function": "Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress., [RefSeq, PubMed]; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Predominant kallikrein protein in the kidney., [UniProtKB]; Gonadectomy influences blood pressure through the kallikrein-kinin system., [RefSeq, PubMed]; These findings suggest that urinary kallidinogenase attenuated flap ischemia and increased the survival of random skin flaps in rats, [RefSeq, PubMed]; Tissue kallikrein 1 and TIMP1 expressed in a coexpression vector synergistically inhibited the proliferation of rat vascular smooth muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030141 secretory granule;GO:0045177 apical part of cell;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0002675 positive regulation of acute inflammatory response;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P36373-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0X3-1", "uniprot_id": [ { "id": "BTBD8_RAT", "url": "https://www.uniprot.org/uniprot/D4A0X3", "type": "external" } ], "mass": 189932.0, "length": 1749, "protein_name": "BTB/POZ domain-containing protein 8", "gene_name": "Btbd8", "organism": "Rat", "refseq_name": "bTB/POZ domain-containing protein 8", "refseq_ac": [ { "id": "NP_001406455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406455", "type": "external" } ], "gene_names_uniprotkb": "Btbd8; Kiaa1107", "gene_names_refseq": "Btbd8", "protein_names_uniprotkb": "BTB/POZ domain-containing protein 8; AP2-interacting clathrin-endocytosis protein; APache", "protein_names_refseq": "AP2-interacting clathrin-endocytosis protein; APache; BTB (POZ) domain containing 8; bTB/POZ domain-containing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:100364240)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29262337", "class_list": "", "function": "Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A452Q762", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030424 axon;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0036466 synaptic vesicle recycling via endosome;GO:0031175 neuron projection development;GO:0016182 synaptic vesicle budding from endosome;GO:0048488 synaptic vesicle endocytosis;GO:0150007 clathrin-dependent synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A0X3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2K4-1", "uniprot_id": [ { "id": "KLH21_RAT", "url": "https://www.uniprot.org/uniprot/D4A2K4", "type": "external" } ], "mass": 66448.0, "length": 597, "protein_name": "Kelch-like protein 21", "gene_name": "Klhl21", "organism": "Rat", "refseq_name": "kelch-like protein 21", "refseq_ac": [ { "id": "NP_001101466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101466", "type": "external" } ], "gene_names_uniprotkb": "Klhl21", "gene_names_refseq": "Klhl21; RGD1305863", "protein_names_uniprotkb": "Kelch-like protein 21", "protein_names_refseq": "kelch-like 21; kelch-like protein 21", "tax_id": 10116, "disease": "", "pathway": " (rno:313743); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005827 polar microtubule;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0035853 chromosome passenger complex localization to spindle midzone;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2K4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3U0-1", "uniprot_id": [ { "id": "GPR22_RAT", "url": "https://www.uniprot.org/uniprot/D4A3U0", "type": "external" } ], "mass": 49133.0, "length": 432, "protein_name": "G protein-coupled receptor 22", "gene_name": "Gpr22", "organism": "Rat", "refseq_name": "G-protein coupled receptor 22", "refseq_ac": [ { "id": "NP_001100192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100192", "type": "external" } ], "gene_names_uniprotkb": "Gpr22", "gene_names_refseq": "Gpr22", "protein_names_uniprotkb": "G protein-coupled receptor 22", "protein_names_refseq": "G-protein coupled receptor 22; probable G-protein coupled receptor 22", "tax_id": 10116, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:298944)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18539757;24937127;38816768", "class_list": "", "function": "Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Demonstrate GRR22 expression in rat heart., [RefSeq, PubMed]; Orphan G protein-coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis., [UniProtKB, UniProtKB]; Orphan receptors GPR22 and GPR162 are expressed in a different way in heart, kidney, brain and aorta of diabetic and non-diabetic rats. We conclude that orphan receptors could be involved in the development of diabetes complications., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4A3U0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A5C3-1", "uniprot_id": [ { "id": "HMGC2_RAT", "url": "https://www.uniprot.org/uniprot/D4A5C3", "type": "external" } ], "mass": 36549.0, "length": 343, "protein_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic", "gene_name": "Hmgcll1", "organism": "Rat", "refseq_name": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic", "refseq_ac": [ { "id": "NP_001263401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263401", "type": "external" } ], "gene_names_uniprotkb": "Hmgcll1", "gene_names_refseq": "Hmgcll1; RGD1565090", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 4.1.3.4", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase L1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1", "tax_id": 10116, "disease": "amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:367112); (R-RNO-77111)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22865860", "class_list": "", "function": "Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues., [UniProtKB]; To evaluate the physiological role of HMGCLL1, recombinant protein was expressed in Pichia pastoris and demonstrated to cleave HMG-CoA to acetoacetate and acetyl-CoA with catalytic and affinity properties comparable with human mitochondrial HMGCL. The available results for COS1 cell expression, as well as endogenous expression in U87 cells, indicate that HMGCLL1 is an extramitochondrial hydroxymethylglutaryl-CoA lyase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004419 hydroxymethylglutaryl-CoA lyase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A5C3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6D8-1", "uniprot_id": [ { "id": "LRRT1_RAT", "url": "https://www.uniprot.org/uniprot/D4A6D8", "type": "external" } ], "mass": 58732.0, "length": 523, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 1", "gene_name": "Lrrtm1", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 1 precursor", "refseq_ac": [ { "id": "NP_001382551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382551", "type": "external" } ], "gene_names_uniprotkb": "Lrrtm1", "gene_names_refseq": "Lrrtm1", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 1", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 1 precursor; leucine-rich repeat transmembrane neuronal protein 1", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:679668); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19285470;35699802;38843836", "class_list": "", "function": "Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis., [RefSeq, PubMed]; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007626 locomotory behavior;GO:0050808 synapse organization;GO:0035640 exploration behavior;GO:0051965 positive regulation of synapse assembly;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D4A6D8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A734-1", "uniprot_id": [ { "id": "MOT12_RAT", "url": "https://www.uniprot.org/uniprot/D4A734", "type": "external" } ], "mass": 52840.0, "length": 486, "protein_name": "Monocarboxylate transporter 12", "gene_name": "Slc16a12", "organism": "Rat", "refseq_name": "monocarboxylate transporter 12", "refseq_ac": [ { "id": "NP_001178566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178566", "type": "external" } ], "gene_names_uniprotkb": "Slc16a12; Mct12", "gene_names_refseq": "MCT 12; RGD1311468; Slc16a12", "protein_names_uniprotkb": "Monocarboxylate transporter 12; MCT 12; Solute carrier family 16 member 12", "protein_names_refseq": "monocarboxylate transporter 12; solute carrier family 16 (monocarboxylic acid transporters), member 12; solute carrier family 16, member 12 (monocarboxylic acid transporter 12)", "tax_id": 10116, "disease": "cataract 47 (Disease Ontology:DOID:0070353)", "pathway": " (rno:309525)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21778275;32781157;33459166;34075817", "class_list": "", "function": "A model whereby the SLC16A12 (c.643C>T) mutation causes juvenile cataract by a defect in protein trafficking rather than by haploinsufficiency. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Monocarboxylate transporter 12 as a guanidinoacetate efflux transporter in renal proximal tubular epithelial cells., [RefSeq, PubMed]; Solute carrier SLC16A12 is critical for creatine and guanidinoacetate handling in the kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005308 creatine transmembrane transporter activity;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046449 creatinine metabolic process;GO:0015881 creatine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D4A734-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9E1-1", "uniprot_id": [ { "id": "HSBPL_RAT", "url": "https://www.uniprot.org/uniprot/D4A9E1", "type": "external" } ], "mass": 8057.0, "length": 72, "protein_name": "Heat shock factor-binding protein 1-like protein 1", "gene_name": "Hsbp1l1", "organism": "Rat", "refseq_name": "heat shock factor-binding protein 1-like protein 1", "refseq_ac": [ { "id": "NP_001129655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129655", "type": "external" } ], "gene_names_uniprotkb": "Hsbp1l1", "gene_names_refseq": "Hsbp1l1", "protein_names_uniprotkb": "Heat shock factor-binding protein 1-like protein 1", "protein_names_refseq": "heat shock factor-binding protein 1-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:100192205)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0070370 cellular heat acclimation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A9E1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20961-1", "uniprot_id": [ { "id": "PAI1_RAT", "url": "https://www.uniprot.org/uniprot/P20961", "type": "external" } ], "mass": 45010.0, "length": 402, "protein_name": "Plasminogen activator inhibitor 1", "gene_name": "Serpine1", "organism": "Rat", "refseq_name": "plasminogen activator inhibitor 1 precursor", "refseq_ac": [ { "id": "NP_036752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036752", "type": "external" } ], "gene_names_uniprotkb": "Serpine1; Pai1; Planh1", "gene_names_refseq": "PAI1A; Pai1aa; Pai1; Planh; RATPAI1A; Serpine1", "protein_names_uniprotkb": "Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; PAI-1; PAI; Serpin E1", "protein_names_refseq": "PAI-1; PAI; endothelial plasminogen activator inhibitor; plasminogen activator inhibitor 1 precursor; plasminogen activator inhibitor 1; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1", "tax_id": 10116, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); renal fibrosis (Disease Ontology:DOID:0050855); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ischemic colitis (Disease Ontology:DOID:0060181); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Coronavirus infectious disease (Disease Ontology:DOID:0080599); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); pleurisy (Disease Ontology:DOID:10247); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); portal vein thrombosis (Disease Ontology:DOID:11695); diabetic angiopathy (Disease Ontology:DOID:11713); Graves' disease (Disease Ontology:DOID:12361); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial hypercholesterolemia (Disease Ontology:DOID:13810); polyneuropathy (Disease Ontology:DOID:1389); thoracic aortic aneurysm (Disease Ontology:DOID:14004); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); toxic shock syndrome (Disease Ontology:DOID:14115); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); neurilemmoma (Disease Ontology:DOID:3192); coronary artery disease (Disease Ontology:DOID:3393); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary fibrosis (Disease Ontology:DOID:3770); placental insufficiency (Disease Ontology:DOID:3891); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); pulmonary hypertension (Disease Ontology:DOID:6432); hematopoietic system disease (Disease Ontology:DOID:74); muscular atrophy (Disease Ontology:DOID:767); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); polycythemia (Disease Ontology:DOID:8432); lung disease (Disease Ontology:DOID:850); diabetic retinopathy (Disease Ontology:DOID:8947); amyloidosis (Disease Ontology:DOID:9120); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24617); (R-RNO-114608); (R-RNO-3000178); (R-RNO-75205); (R-RNO-9769739)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "2298740;28722352;29393594;29644896;30449218;30982977;31257474;3149611;32748313", "class_list": "", "function": "Cells with NF-kappaB p65 knock-down showed significant decreases in TF, PAI-1, p65, p-p65, p-IkappaB expressions following LPS stimulation, [RefSeq, PubMed]; MiR210/Serpine1 and miR378/Fos play a prominent role in regulating inflammation in a cute kidney injury rat model., [RefSeq, PubMed]; PAI-1 gene silencing can promote the recanalization of venous thrombosis by enhancement of the luminal formation ability of rats' endothelial progenitor cells., [RefSeq, PubMed]; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results suggest that miR-17~92 regulates the PASMC contractile phenotype and proliferation coordinately and synergistically by direct and indirect targeting of PAI-1., [RefSeq, PubMed]; Upregulated miR-224-5p suppresses osteoblast differentiation by increasing the expression of Pai-1 in the lumbar spine of a rat model of congenital kyphoscoliosis., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 79, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0042583 chromaffin granule", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0071559 response to transforming growth factor beta;GO:0097187 dentinogenesis;GO:0071409 cellular response to cycloheximide;GO:1901331 positive regulation of odontoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23505-1", "uniprot_id": [ { "id": "GP42_RAT", "url": "https://www.uniprot.org/uniprot/P23505", "type": "external" } ], "mass": 26025.0, "length": 233, "protein_name": "Cell surface glycoprotein gp42", "gene_name": "Fcrl6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fcrl6", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell surface glycoprotein gp42", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:305103)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1845873", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019903 protein phosphatase binding;GO:0019902 phosphatase binding;GO:0042289 MHC class II protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23505-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16235-1", "uniprot_id": [ { "id": "LSHR_RAT", "url": "https://www.uniprot.org/uniprot/P16235", "type": "external" } ], "mass": 78036.0, "length": 700, "protein_name": "Lutropin-choriogonadotropic hormone receptor", "gene_name": "Lhcgr", "organism": "Rat", "refseq_name": "lutropin-choriogonadotropic hormone receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_037110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037110", "type": "external" } ], "gene_names_uniprotkb": "Lhcgr; LHCGR", "gene_names_refseq": "LH/CG-R; LSH-R; LSHR; Lhcgr; Lhr", "protein_names_uniprotkb": "Lutropin-choriogonadotropic hormone receptor; LH/CG-R; LSH-R; Luteinizing hormone receptor", "protein_names_refseq": "LH receptor; LH/CG receptor; luteinizing hormone receptor; luteinizing hormone/chorionic gonadotropin receptor; lutropin-choriogonadotropic hormone receptor isoform 1 precursor; lutropin-choriogonadotropic hormone receptor", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); familial male-limited precocious puberty (Disease Ontology:DOID:0111545); Leydig cell hypoplasia (Disease Ontology:DOID:0112259); muscular dystrophy-dystroglycanopathy type B15 (Disease Ontology:DOID:0112376); breast cancer (Disease Ontology:DOID:1612); gonadal disease (Disease Ontology:DOID:2277); Leydig cell tumor (Disease Ontology:DOID:2696); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603)", "pathway": " (rno:25477); (R-RNO-375281)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "1353463;15866423;1714448;1755859;1976554;2019252;2040640;2174034;2281186;2502842;2601325;27940300;28605466;2925659;31041823;32422603;7665591;7776964", "class_list": "", "function": "Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model., [RefSeq, PubMed]; MiR-122 plays a regulatory role in LHCGR expression., [RefSeq, PubMed]; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effect of clomiphene citrate and human chorionic gonadotropin on the expression of CatSper1, CatSper2, LHCGR, and SF1 genes, as well as the structural changes in testicular tissue of adult rats., [RefSeq, PubMed]; The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P70646;Q63807;Q63808;Q63809;Q6LDI7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004964 luteinizing hormone receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0046544 development of secondary male sexual characteristics;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P16235-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000100010000.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1Q3-1", "uniprot_id": [ { "id": "PCAT2_RAT", "url": "https://www.uniprot.org/uniprot/P0C1Q3", "type": "external" } ], "mass": 59829.0, "length": 544, "protein_name": "Lysophosphatidylcholine acyltransferase 2", "gene_name": "Lpcat2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lpcat2; Aytl1a; Aytl1; Lpcat2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2; 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 1; LPC acyltransferase 2; LPCAT-2; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100359680); (R-RNO-1482788)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Exhibits both acyltransferase and acetyltransferase activities (By similarity). Activity is calcium-dependent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0061024 membrane organization;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006650 glycerophospholipid metabolic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C1Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14650-1", "uniprot_id": [ { "id": "PERT_RAT", "url": "https://www.uniprot.org/uniprot/P14650", "type": "external" } ], "mass": 101460.0, "length": 914, "protein_name": "Thyroid peroxidase", "gene_name": "Tpo", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpo", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroid peroxidase; 1.11.1.8; TPO", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 2A (Disease Ontology:DOID:0112186); glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (rno:54314); (R-RNO-209968)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2691880;2813071", "class_list": "", "function": "Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.8", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0020037 heme binding;GO:0004601 peroxidase activity;GO:0004447 iodide peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006979 response to oxidative stress;GO:0033993 response to lipid;GO:0042446 hormone biosynthetic process;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14650-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09017-1", "uniprot_id": [ { "id": "NR2F6_RAT", "url": "https://www.uniprot.org/uniprot/O09017", "type": "external" } ], "mass": 41730.0, "length": 390, "protein_name": "Nuclear receptor subfamily 2 group F member 6", "gene_name": "Nr2f6", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 2 group F member 6", "refseq_ac": [ { "id": "NP_620813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620813", "type": "external" } ], "gene_names_uniprotkb": "Nr2f6; Ear2; Erbal2", "gene_names_refseq": "Nr2f6", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group F member 6; COUPg; EAR-2; Ovalbumin upstream promoter gamma nuclear receptor; V-erbA-related protein 2", "protein_names_refseq": "COUPg; V-erbA-related protein 2; V-erbA-related protein EAR-2; nuclear receptor subfamily 2 group F member 6; orphan nuclear receptor EAR-2; ovalbumin upstream promoter gamma nuclear receptor rCOUPg", "tax_id": 10116, "disease": "", "pathway": " (rno:245980); (R-RNO-383280)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16721029;29393594;9343308", "class_list": "", "function": "Cloning of rat pituitary COUP-TFII and EAR-2 genes, demonstrated that they are specifically expressed in lactotropes, and strongly suggested that they may play a role in modulating prolactin (PRL) gene expression during pregnancy., [RefSeq, PubMed]; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC) (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O09017-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20717-1", "uniprot_id": [ { "id": "PADI2_RAT", "url": "https://www.uniprot.org/uniprot/P20717", "type": "external" } ], "mass": 75356.0, "length": 665, "protein_name": "Protein-arginine deiminase type-2", "gene_name": "Padi2", "organism": "Rat", "refseq_name": "protein-arginine deiminase type-2", "refseq_ac": [ { "id": "NP_058922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058922", "type": "external" } ], "gene_names_uniprotkb": "Padi2; Pad2; Pdi2; Pdi", "gene_names_refseq": "Padi2; Pdi2", "protein_names_uniprotkb": "Protein-arginine deiminase type-2; 3.5.3.15; Peptidylarginine deiminase II; Protein-arginine deiminase type II", "protein_names_refseq": "peptidyl arginine deiminase, type 2; peptidyl arginine deiminase, type II; peptidylarginine deiminase II; protein-arginine deiminase type II; protein-arginine deiminase type-2", "tax_id": 10116, "disease": "tuberous sclerosis (Disease Ontology:DOID:13515); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:29511); (R-RNO-3247509); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1601308;17579814;19641855;2768262", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These biochemical and immunohistochemical results suggest that PAD2 might play an important role in the pathology of early Alzheimer's disease, [RefSeq, PubMed]; This report revealed the expression of PAD2 by microglia in the prenatal cerebrum at embryonic stages E19-E21., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030331 nuclear estrogen receptor binding;GO:0140794 histone arginine deiminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000791 euchromatin", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:1901624 negative regulation of lymphocyte chemotaxis;GO:0006338 chromatin remodeling;GO:1990830 cellular response to leukemia inhibitory factor;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20717-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97738-1", "uniprot_id": [ { "id": "NPTX2_RAT", "url": "https://www.uniprot.org/uniprot/P97738", "type": "external" } ], "mass": 47429.0, "length": 432, "protein_name": "Neuronal pentraxin-2", "gene_name": "Nptx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nptx2; Narp", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal pentraxin-2; NP-II; NP2; Neuronal activity-regulated pentraxin; Neuronal pentraxin II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288475)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8786423", "class_list": "", "function": "Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043083 synaptic cleft;GO:0098892 extrinsic component of postsynaptic specialization membrane;GO:0098793 presynapse", "go_biological_process": "GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97738-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70579-1", "uniprot_id": [ { "id": "GRM8_RAT", "url": "https://www.uniprot.org/uniprot/P70579", "type": "external" } ], "mass": 101867.0, "length": 908, "protein_name": "Metabotropic glutamate receptor 8", "gene_name": "Grm8", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 8 precursor", "refseq_ac": [ { "id": "NP_071538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071538", "type": "external" } ], "gene_names_uniprotkb": "Grm8; Gprc1h; Mglur8", "gene_names_refseq": "Glur8; Gprc1h; Grm8; Mglur8; mGluR8b; mGlur", "protein_names_uniprotkb": "Metabotropic glutamate receptor 8; mGluR8", "protein_names_refseq": "G protein-coupled receptor, family C, group 1, member H; glutamate receptor, metabotropic 8; metabotropic glutamate receptor 8 precursor; metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinsonism (Disease Ontology:DOID:0080855); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:60590); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11122333;27497709;29588465;32016558;38419440;9016353", "class_list": "", "function": "G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity., [UniProtKB]; Metabotropic Glutamate Receptor 8 Suppresses M1 Polarization in Microglia by Alleviating Endoplasmic Reticulum Stress and Mitochondrial Dysfunction., [RefSeq, PubMed]; Results show that group III mGluRs negatively modulate TRPA1 activity on cutaneous nociceptors. Furthermore, it is likely that this modulation occurs intracellularly at the level of the cAMP/PKA pathway. This study demonstrates that group III agonists may be effective in the treatment of mechanical hypersensitivity which can develop as a result of inflammation, nerve injury, chemotherapy and other disease states., [RefSeq, PubMed]; Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum., [RefSeq, PubMed]; This study shows via knockdown of endogenous MEF2A in primary neuronal culture, that MEF2A is specifically required for Group I metabotropic glutamate receptor (mGluR)-mediated GluA2 internalisation, but does not regulate AMPAR expression or trafficking under basal conditions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001642 group III metabotropic glutamate receptor activity;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0019233 sensory perception of pain;GO:0035249 synaptic transmission, glutamatergic;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70579-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88600-1", "uniprot_id": [ { "id": "HSP74_RAT", "url": "https://www.uniprot.org/uniprot/O88600", "type": "external" } ], "mass": 94057.0, "length": 840, "protein_name": "Heat shock 70 kDa protein 4", "gene_name": "Hspa4", "organism": "Rat", "refseq_name": "heat shock 70 kDa protein 4", "refseq_ac": [ { "id": "NP_705893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705893", "type": "external" } ], "gene_names_uniprotkb": "Hspa4; Hsph2; Irp94", "gene_names_refseq": "Hsp110; Hsp70; Hspa4; irp94", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4; Ischemia responsive 94 kDa protein", "protein_names_refseq": "expressed in rat brain after transient forebrain ischemia; heat shock 70 kDa protein 4; heat shock protein 4; heat shock protein family A member 4; ischemia responsive 94 kDa protein", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); Chagas disease (Disease Ontology:DOID:12140); Parkinson's disease (Disease Ontology:DOID:14330); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:266759); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10098860;11990455;12857439;18683930;22673903;29374537;32917949;35456946;37200358;38597327", "class_list": "", "function": "As Hsp70 may transfer from glial to neuronal cells, its synthesis by astrocytes may represent an important survival mechanism by which astrocytes protect neurons against oxidative-mediated cell death, [RefSeq, PubMed]; Dynamically changed HSP70 after reperfusion following cerebral infarction in human and rats: correlation with p38 MAPK., [RefSeq, PubMed]; Excessive expression of HSP70 may cause injury to liver after severe multiple injury., [RefSeq, PubMed]; Heat shock protein 70 protects the lungs from hyperoxic injury in a neonatal rat model of bronchopulmonary dysplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses. Publication Status: Online-Only, [RefSeq, PubMed]; Male rats were trained in contextual fear conditioning task and HSP70 content was analyzed by western blot in the hippocampus at different time points. We observed rapid and transient elevations in HSP70 60min following training. Double immunofluorescence with GFAP and HSP72 revealed that astrocytes were not the site for HSP72 induction by CFC training., [RefSeq, PubMed]; Overexpression of miR-144-3p alleviates polycystic ovaries syndrome through targeting expression of HSP-70., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0001822 kidney development;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O88600-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55161-1", "uniprot_id": [ { "id": "NCKP1_RAT", "url": "https://www.uniprot.org/uniprot/P55161", "type": "external" } ], "mass": 128865.0, "length": 1128, "protein_name": "Nck-associated protein 1", "gene_name": "Nckap1", "organism": "Rat", "refseq_name": "nck-associated protein 1", "refseq_ac": [ { "id": "NP_113806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113806", "type": "external" } ], "gene_names_uniprotkb": "Nckap1; Hem2; Nap1", "gene_names_refseq": "Nckap1", "protein_names_uniprotkb": "Nck-associated protein 1; Membrane-associated protein HEM-2; NAP 1; p125Nap1", "protein_names_refseq": "NAP 1; membrane-associated protein HEM-2; nck-associated protein 1; p125Nap1", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (rno:58823); (R-RNO-2029482); (R-RNO-4420097); (R-RNO-5663213); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "18683930;7643388;8605018", "class_list": "", "function": "Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0030027 lamellipodium;GO:0098794 postsynapse;GO:0031209 SCAR complex", "go_biological_process": "GO:0007354 zygotic determination of anterior/posterior axis, embryo;GO:0010172 embryonic body morphogenesis;GO:0048570 notochord morphogenesis;GO:0048340 paraxial mesoderm morphogenesis;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55161-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35764-1", "uniprot_id": [ { "id": "NPTXR_RAT", "url": "https://www.uniprot.org/uniprot/O35764", "type": "external" } ], "mass": 52371.0, "length": 494, "protein_name": "Neuronal pentraxin receptor", "gene_name": "Nptxr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nptxr; Npr", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal pentraxin receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "10748068;24090084;38843836;9261167", "class_list": "", "function": "May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 16, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0019903 protein phosphatase binding;GO:0008029 pentraxin receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0042542 response to hydrogen peroxide;GO:0099150 regulation of postsynaptic specialization assembly;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "O35764-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M2Z5-1", "uniprot_id": [ { "id": "NCMAP_RAT", "url": "https://www.uniprot.org/uniprot/F1M2Z5", "type": "external" } ], "mass": 10772.0, "length": 100, "protein_name": "Noncompact myelin-associated protein", "gene_name": "Ncmap", "organism": "Rat", "refseq_name": "noncompact myelin-associated protein", "refseq_ac": [ { "id": "NP_001240847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240847", "type": "external" } ], "gene_names_uniprotkb": "Ncmap", "gene_names_refseq": "Mp11; Ncmap", "protein_names_uniprotkb": "Noncompact myelin-associated protein; MP11; Myelin protein of 11 kDa", "protein_names_refseq": "myelin protein of 11 kDa; noncompact myelin-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:689826)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18650334", "class_list": "", "function": "Plays a role in myelin formation., [UniProtKB, PubMed]; This study identified an evolutionarily conserved novel component of myelin called Mp11. The Mp11 genomic locus contains multiple conserved Egr binding sites, and Mp11 induction is regulated by the expression of Egr2. and expression in peripheral nerve., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043220 Schmidt-Lanterman incisure;GO:0033270 paranode region of axon", "go_biological_process": "GO:0032290 peripheral nervous system myelin formation;GO:0031643 positive regulation of myelination;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M2Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M649-1", "uniprot_id": [ { "id": "NLRC4_RAT", "url": "https://www.uniprot.org/uniprot/F1M649", "type": "external" } ], "mass": 116142.0, "length": 1023, "protein_name": "NLR family CARD domain-containing protein 4", "gene_name": "Nlrc4", "organism": "Rat", "refseq_name": "NLR family CARD domain-containing protein 4", "refseq_ac": [ { "id": "NP_001296361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296361", "type": "external" } ], "gene_names_uniprotkb": "Nlrc4; Ipaf", "gene_names_refseq": "Card12; Ipaf; Nlrc4", "protein_names_uniprotkb": "NLR family CARD domain-containing protein 4; Ice protease-activating factor; Ipaf", "protein_names_refseq": "NLR family CARD domain-containing protein 4; caspase recruitment domain family, member 12; ice protease-activating factor", "tax_id": 10116, "disease": "familial cold autoinflammatory syndrome 4 (Disease Ontology:DOID:0090065)", "pathway": " (rno:298784)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29393594;32645874;34848837", "class_list": "", "function": "Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria., [UniProtKB, UniProtKB]; The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0061133 endopeptidase activator activity;GO:0089720 caspase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0072557 IPAF inflammasome complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1M649-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00697-1", "uniprot_id": [ { "id": "LYSC1_RAT", "url": "https://www.uniprot.org/uniprot/P00697", "type": "external" } ], "mass": 16729.0, "length": 148, "protein_name": "Lysozyme C-1", "gene_name": "Lyz1; Lyz2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lyz1; Lyz2; Lyz", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysozyme C-1; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "", "tax_id": 10116, "disease": "pervasive developmental disorder (Disease Ontology:DOID:0060040); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); blepharospasm (Disease Ontology:DOID:529)", "pathway": " (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8081549;851497", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0005795 Golgi stack", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P00697-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97697-1", "uniprot_id": [ { "id": "IMPA1_RAT", "url": "https://www.uniprot.org/uniprot/P97697", "type": "external" } ], "mass": 30511.0, "length": 277, "protein_name": "Inositol monophosphatase 1", "gene_name": "Impa1", "organism": "Rat", "refseq_name": "inositol monophosphatase 1", "refseq_ac": [ { "id": "NP_114446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114446", "type": "external" } ], "gene_names_uniprotkb": "Impa1; Imp", "gene_names_refseq": "Impa1-L; Impa1", "protein_names_uniprotkb": "Inositol monophosphatase 1; 3.1.3.25; 3.1.3.94; D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1", "protein_names_refseq": "D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol (myo)-1(or 4)-monophosphatase 1; inositol monophosphatase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 59 (Disease Ontology:DOID:0081221); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:83523); (R-RNO-1855183)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1377913;22673903;30604625;31897490;33626357;9210592;9462881", "class_list": "", "function": "Conclude that the formation of the newly discovered RAGE-IMPA1 complex could be responsible for the stimulation of inositol pathways and activation of Akt signaling in pulmonary arterial hypertension, [RefSeq, PubMed]; Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity., [RefSeq, PubMed]; Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity., [RefSeq, PubMed]; Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol (PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (By similarity). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate (PubMed:9462881)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" }, { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0031403 lithium ion binding;GO:0052834 inositol monophosphate phosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0006796 phosphate-containing compound metabolic process;GO:0006661 phosphatidylinositol biosynthetic process;GO:0006021 inositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P97697-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35787-1", "uniprot_id": [ { "id": "KIF1C_RAT", "url": "https://www.uniprot.org/uniprot/O35787", "type": "external" } ], "mass": 122334.0, "length": 1097, "protein_name": "Kinesin-like protein KIF1C", "gene_name": "Kif1c", "organism": "Rat", "refseq_name": "kinesin-like protein KIF1C", "refseq_ac": [ { "id": "NP_665884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665884", "type": "external" } ], "gene_names_uniprotkb": "Kif1c; Kif1d", "gene_names_refseq": "Kif1c", "protein_names_uniprotkb": "Kinesin-like protein KIF1C; Kinesin-like protein KIF1D", "protein_names_refseq": "kinesin 1C; kinesin-like protein KIF1C; kinesin-like protein KIF1D", "tax_id": 10116, "disease": "spastic ataxia 2 (Disease Ontology:DOID:0050941); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:113886); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;25344256;38726004;9582454", "class_list": "", "function": "KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes., [RefSeq, PubMed]; Probable motor protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1990048 anterograde neuronal dense core vesicle transport;GO:0007017 microtubule-based process;GO:1990049 retrograde neuronal dense core vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35787-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97578-1", "uniprot_id": [ { "id": "FEZ2_RAT", "url": "https://www.uniprot.org/uniprot/P97578", "type": "external" } ], "mass": 42086.0, "length": 375, "protein_name": "Fasciculation and elongation protein zeta-2", "gene_name": "Fez2", "organism": "Rat", "refseq_name": "fasciculation and elongation protein zeta-2 isoform 1", "refseq_ac": [ { "id": "NP_446052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446052", "type": "external" } ], "gene_names_uniprotkb": "Fez2; Zrp", "gene_names_refseq": "Fez2; Zrp", "protein_names_uniprotkb": "Fasciculation and elongation protein zeta-2; Zygin II; Zygin-2; Zygin-related protein types I/II", "protein_names_refseq": "fasciculation and elongation protein zeta-2 isoform 1; synaptotagmin interacting protein zyginII; zygin II; zygin-2; zygin-related protein types I/II", "tax_id": 10116, "disease": "Jacobsen Syndrome (Disease Ontology:DOID:0111723)", "pathway": " (rno:94269)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14697253", "class_list": "", "function": "FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner, [RefSeq, PubMed]; Involved in axonal outgrowth and fasciculation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q76LN1;Q9JJ35;Q9JJ36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97578-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56478-1", "uniprot_id": [ { "id": "IL7_RAT", "url": "https://www.uniprot.org/uniprot/P56478", "type": "external" } ], "mass": 17709.0, "length": 154, "protein_name": "Interleukin-7", "gene_name": "Il7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il7", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-7; IL-7", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 130 with HPV-related verrucosis (Disease Ontology:DOID:0061171); COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); high grade glioma (Disease Ontology:DOID:3070); periodontal disease (Disease Ontology:DOID:3388); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (R-RNO-1266695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005139 interleukin-7 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0002360 T cell lineage commitment;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56478-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3LUD4-1", "uniprot_id": [ { "id": "LZTS2_RAT", "url": "https://www.uniprot.org/uniprot/Q3LUD4", "type": "external" } ], "mass": 72493.0, "length": 670, "protein_name": "Leucine zipper putative tumor suppressor 2", "gene_name": "Lzts2", "organism": "Rat", "refseq_name": "leucine zipper putative tumor suppressor 2", "refseq_ac": [ { "id": "NP_001014269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014269", "type": "external" } ], "gene_names_uniprotkb": "Lzts2; LAPSER1; LZTS2; Lapser1", "gene_names_refseq": "Lapser1; Lzts2", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 2; Protein LAPSER1", "protein_names_refseq": "leucine zipper putative tumor suppressor 2; protein LAPSER1", "tax_id": 10116, "disease": "urinary system disease (Disease Ontology:DOID:18)", "pathway": " (rno:365468)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17351128;18490357;19703901;22673903", "class_list": "", "function": "Analysis of cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses, [RefSeq, PubMed]; LAPSER1 localizes to the centrosomes & midbodies in mitotic cells. LAPSER1 participates in cytokinesis by interacting with p80 katanin, the disruption of which may potentially cause genetic instability and cancer., [RefSeq, PubMed]; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24K74", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0031982 vesicle", "go_biological_process": "GO:0051013 microtubule severing;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3LUD4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F8WLE0-1", "uniprot_id": [ { "id": "KIF28_RAT", "url": "https://www.uniprot.org/uniprot/F8WLE0", "type": "external" } ], "mass": 115542.0, "length": 1034, "protein_name": "Kinesin-like protein KIF28", "gene_name": "Kif28", "organism": "Rat", "refseq_name": "kinesin-like protein KIF28", "refseq_ac": [ { "id": "NP_001257314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257314", "type": "external" } ], "gene_names_uniprotkb": "Kif28; Klp6", "gene_names_refseq": "KLP6; Kif28p; Kif28; RGD1559696", "protein_names_uniprotkb": "Kinesin-like protein KIF28; Kinesin family member 28; Kinesin-like protein 6", "protein_names_refseq": "Kinesin-like protein 6; kinesin family member 28, pseudogene; kinesin-like protein KIF28P; kinesin-like protein KIF28; kinesin-like protein KLP6", "tax_id": 10116, "disease": "autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:289309); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21693574", "class_list": "", "function": "Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0031966 mitochondrial membrane;GO:0005871 kinesin complex", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0072384 organelle transport along microtubule;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F8WLE0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35331-1", "uniprot_id": [ { "id": "PDXK_RAT", "url": "https://www.uniprot.org/uniprot/O35331", "type": "external" } ], "mass": 34908.0, "length": 312, "protein_name": "Pyridoxal kinase", "gene_name": "Pdxk", "organism": "Rat", "refseq_name": "pyridoxal kinase", "refseq_ac": [ { "id": "NP_113957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113957", "type": "external" } ], "gene_names_uniprotkb": "Pdxk; Pkh", "gene_names_refseq": "Pdxk", "protein_names_uniprotkb": "Pyridoxal kinase; 2.7.1.35; Pyridoxine kinase", "protein_names_refseq": "pyridoxal (pyridoxine, vitamin B6) kinase; pyridoxal kinase; pyridoxine kinase", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:83578); (R-RNO-6798695); (R-RNO-964975)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "35050500", "class_list": "", "function": "Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016773 phosphotransferase activity, alcohol group as acceptor;GO:0070280 pyridoxal binding;GO:0008478 pyridoxal kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0032094 response to food;GO:0032570 response to progesterone;GO:0009636 response to toxic substance;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35331-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08878-1", "uniprot_id": [ { "id": "GPER1_RAT", "url": "https://www.uniprot.org/uniprot/O08878", "type": "external" } ], "mass": 42260.0, "length": 375, "protein_name": "G protein-coupled estrogen receptor 1", "gene_name": "Gper1", "organism": "Rat", "refseq_name": "G-protein coupled estrogen receptor 1", "refseq_ac": [ { "id": "NP_598257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598257", "type": "external" } ], "gene_names_uniprotkb": "Gper1; Cmkrl2; Gper; Gpr30; Gpr41", "gene_names_refseq": "GPR41; Gper1; Gper; Gpr30", "protein_names_uniprotkb": "G protein-coupled estrogen receptor 1; Chemoattractant receptor-like 2; G protein-coupled receptor 30; G protein-coupled receptor 41; Membrane estrogen receptor; mER", "protein_names_refseq": "G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; chemoattractant receptor-like 2; chemokine receptor-like 2; mER; membrane estrogen receptor", "tax_id": 10116, "disease": "generalized anxiety disorder (Disease Ontology:DOID:14320); melanoma (Disease Ontology:DOID:1909)", "pathway": " (rno:171104); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "16780796;17872373;19179659;19420011;20132863;21242460;21354433;22306576;22919059;23283935;23300088;23822769;36845134;37257405;38134189;39063107;39138706;9168987", "class_list": "", "function": "Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Brain-derived estrogen: a critical player in maintaining cognitive health of aged female rats, possibly involving GPR30., [RefSeq, PubMed]; G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Also functions as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells., [UniProtKB, PubMed, PubMed]; GPER activation attenuates cardiac dysfunction by upregulating the SIRT1/3-AMPK-UCP2 pathway in postmenopausal diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; GPR30, a transmembrane receptor for estrogen, is localized to the plasma membrane of CA2 pyramidal neuronal cells of the hippocampus in rat brain, [RefSeq, PubMed]; GPR30-mediated non-classic estrogen pathway in mast cells participates in endometriosis pain via the production of FGF2. Publication Status: Online-Only, [RefSeq, PubMed]; Joint Inflammation Correlates with Joint GPR30 Expression in Males and Hippocampal GPR30 Expression in Females in a Rat Model of Rheumatoid Arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that GPR30 may serve primarily as a nongenomic transducer of estrogen actions in the hypothalamo-neurohypophyseal system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005496 steroid binding;GO:1990239 steroid hormone binding;GO:0030284 nuclear estrogen receptor activity;GO:1903924 estradiol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0002695 negative regulation of leukocyte activation;GO:0010948 negative regulation of cell cycle process;GO:0030264 nuclear fragmentation involved in apoptotic nuclear change;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "O08878-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70503-1", "uniprot_id": [ { "id": "NR0B1_RAT", "url": "https://www.uniprot.org/uniprot/P70503", "type": "external" } ], "mass": 52756.0, "length": 472, "protein_name": "Nuclear receptor subfamily 0 group B member 1", "gene_name": "Nr0b1", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 0 group B member 1", "refseq_ac": [ { "id": "NP_445769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445769", "type": "external" } ], "gene_names_uniprotkb": "Nr0b1; Ahch; Dax1", "gene_names_refseq": "Ahch; DAX-1; Nr0b1", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1", "protein_names_refseq": "adrenal hypoplasia, congenital homolog; nuclear receptor DAX-1; nuclear receptor subfamily 0 group B member 1", "tax_id": 10116, "disease": "X-linked adrenal hypoplasia congenita (Disease Ontology:DOID:0080156); 46,XY sex reversal 2 (Disease Ontology:DOID:0111777)", "pathway": " (rno:58850); (R-RNO-383280)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "30342431;36075317;36233086;8754790", "class_list": "", "function": "Heat stress upregulates aromatases expression through nuclear DAX-1 deficiency in R2C Leydig tumor cells., [RefSeq, PubMed]; Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; In conclusion, the presented data revealed that the pituitary Nr5a1/Ctnnb1/Nr0b1 system is controlled by endogenous Gnrh network activity, and hypothalamic-derived regulatory inputs can affect the processes responsible for gene transcription, translation, and protein intracellular translocation., [RefSeq, PubMed]; Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63152", "ec_number_list": [], "go_molecular_function": "GO:0032448 DNA hairpin binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0016607 nuclear speck;GO:0005840 ribosome", "go_biological_process": "GO:0007530 sex determination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70503-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20068-1", "uniprot_id": [ { "id": "NEUT_RAT", "url": "https://www.uniprot.org/uniprot/P20068", "type": "external" } ], "mass": 19564.0, "length": 169, "protein_name": "Neurotensin/neuromedin N", "gene_name": "Nts", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nts", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurotensin/neuromedin N; NmN-125", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sciatic neuropathy (Disease Ontology:DOID:11446); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:299757); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "2832414;8462460;8471039", "class_list": "", "function": "Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QV80", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0071855 neuropeptide receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0030133 transport vesicle", "go_biological_process": "GO:0090325 regulation of locomotion involved in locomotory behavior;GO:0001889 liver development;GO:0007218 neuropeptide signaling pathway;GO:0008542 visual learning;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20068-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88302-1", "uniprot_id": [ { "id": "GNA15_RAT", "url": "https://www.uniprot.org/uniprot/O88302", "type": "external" } ], "mass": 43332.0, "length": 374, "protein_name": "Guanine nucleotide-binding protein subunit alpha-15", "gene_name": "Gna15", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit alpha-15", "refseq_ac": [ { "id": "NP_445994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445994", "type": "external" } ], "gene_names_uniprotkb": "Gna15", "gene_names_refseq": "Gna15; Hg1l", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-15; G alpha-15; G protein subunit alpha-15", "protein_names_refseq": "g alpha-15; guanine nucleotide binding protein, alpha 15; guanine nucleotide-binding protein subunit alpha-15; heterotrimeric guanine nucleotide-binding protein 1l", "tax_id": 10116, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:89788)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9685675", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB]; Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses., [UniProtKB, UniProtKB]; Member of the G-protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0019722 calcium-mediated signaling;GO:0001508 action potential;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88302-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31246-1", "uniprot_id": [ { "id": "HXA2_RAT", "url": "https://www.uniprot.org/uniprot/P31246", "type": "external" } ], "mass": 40827.0, "length": 372, "protein_name": "Homeobox protein Hox-A2", "gene_name": "Hoxa2", "organism": "Rat", "refseq_name": "homeobox protein Hox-A2", "refseq_ac": [ { "id": "NP_036713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036713", "type": "external" } ], "gene_names_uniprotkb": "Hoxa2; Hox-1.11; Hoxa-2; NEWGENE_2813", "gene_names_refseq": "Hoxa-2; Hoxa11; Hoxa2l; Hoxa2; RATHOX111A; hox-1.11", "protein_names_uniprotkb": "Homeobox protein Hox-A2; Homeobox protein Hox-1.11", "protein_names_refseq": "Homeobox gene A11; Homeobox gene A2; homeo box A2; homeobox protein Hox-1.11; homeobox protein Hox-A2", "tax_id": 10116, "disease": "", "pathway": " (rno:103690123)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1361191;21479584;7915120", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]; The impact of Hoxa2 over-expression on the proliferation and differentiation of CG4-SHoxa2 cells was investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0021568 rhombomere 2 development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31246-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31390-1", "uniprot_id": [ { "id": "HRH1_RAT", "url": "https://www.uniprot.org/uniprot/P31390", "type": "external" } ], "mass": 55693.0, "length": 486, "protein_name": "Histamine H1 receptor", "gene_name": "Hrh1", "organism": "Rat", "refseq_name": "histamine H1 receptor", "refseq_ac": [ { "id": "NP_058714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058714", "type": "external" } ], "gene_names_uniprotkb": "Hrh1", "gene_names_refseq": "Hisr; Hrh1", "protein_names_uniprotkb": "Histamine H1 receptor; H1R; HH1R", "protein_names_refseq": "H1R; HH1R; histamine H1 receptor", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:24448); (R-RNO-390650); (R-RNO-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12419527;12581497;12634496;22673903;28964277;29498008;34638832;36766852;38483045;7678492", "class_list": "", "function": "Activation of H1-receptors in vasopressinergic neurons results in downstream activation of NO synthase, which then mediates the H1-receptor effects., [RefSeq, PubMed]; Findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission., [RefSeq, PubMed]; G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:7678492). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity)., [UniProtKB, PubMed, UniProtKB]; G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter. Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; H1, H2, and H3 histamine receptor mRNA detected in modiolus but not in lateral and medial portions of the cochlea. First evidence of H1, H2, and H3 histamine receptor mRNA in rat cochlea., [RefSeq, PubMed]; Increased Nuclear FOXP2 Is Related to Reduced Neural Stem Cell Number and Increased Neurogenesis in the Dorsal Telencephalon of Embryos of Diabetic Rats through Histamine H1 Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; ThEA stimulation evoked amylase release via H1 receptor but was not followed by L-arginine/nitric oxide pathway activation., [RefSeq, PubMed]; The histaminergic afferent inputs in the striatum may modulate both dopamine D1 and D2 receptor-expressing medium spiny projection neurons by activation of postsynaptic histamine H1 and H2 receptors., [RefSeq, PubMed]; The role of histamine H1 receptor in the anterior cingulate cortex on nociception level following acute restraint stress in male rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004969 histamine receptor activity;GO:0051381 histamine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007613 memory;GO:0008542 visual learning;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P31390-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54853-1", "uniprot_id": [ { "id": "KCNH6_RAT", "url": "https://www.uniprot.org/uniprot/O54853", "type": "external" } ], "mass": 105706.0, "length": 950, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH6", "gene_name": "Kcnh6", "organism": "Rat", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH6", "refseq_ac": [ { "id": "NP_446389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446389", "type": "external" } ], "gene_names_uniprotkb": "Kcnh6; Erg2", "gene_names_refseq": "Erg2; Kcnh6", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH6; ERG-2; Eag-related protein 2; Ether-a-go-go-related gene potassium channel 2; Ether-a-go-go-related protein 2; Potassium voltage-gated channel subfamily H member 6; Voltage-gated potassium channel subunit Kv11.2", "protein_names_refseq": "ERG-2; Eag-related gene member 2; eag-related protein 2; ether-a-go-go-related gene potassium channel 2; ether-a-go-go-related protein 2; potassium channel, voltage gated eag related subfamily H, member 6; potassium voltage-gated channel, subfamily H (eag-related), member 6; voltage-gated inwardly rectifying potassium channel KCNH6; voltage-gated potassium channel subunit Kv11.2", "tax_id": 10116, "disease": "short QT syndrome (Disease Ontology:DOID:0050793); long QT syndrome 2 (Disease Ontology:DOID:0110645); heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826); long QT syndrome (Disease Ontology:DOID:2843); glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:116745); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10718922;11212207;11425889;21044070;9390998", "class_list": "", "function": "Erg2 was found to bind to promoters of several lipid biosynthesis genes during the formation of lipid-rich myelin., [RefSeq, PubMed]; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9390998). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:11212207, PubMed:9390998). Activates even more slowly than KCNH2 (PubMed:9390998)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0086013 membrane repolarization during cardiac muscle cell action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0006813 potassium ion transport;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54853-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C089-1", "uniprot_id": [ { "id": "PTPM1_RAT", "url": "https://www.uniprot.org/uniprot/P0C089", "type": "external" } ], "mass": 21886.0, "length": 193, "protein_name": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1", "gene_name": "Ptpmt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptpmt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; 3.1.3.16; 3.1.3.27; 3.1.3.48; Protein-tyrosine phosphatase mitochondrial 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29390)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16039589", "class_list": "", "function": "Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (PubMed:16039589). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (PubMed:16039589). Probably involved in regulation of insulin secretion in pancreatic beta cells (PubMed:16039589). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008962 phosphatidylglycerophosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0102091 phosphatidylinositol-5-phosphate phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:2001242 regulation of intrinsic apoptotic signaling pathway;GO:0043653 mitochondrial fragmentation involved in apoptotic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C089-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10165-1", "uniprot_id": [ { "id": "PRPG2_RAT", "url": "https://www.uniprot.org/uniprot/P10165", "type": "external" } ], "mass": 30026.0, "length": 295, "protein_name": "Proline-rich proteoglycan 2", "gene_name": "Prpg2; Prpmp5", "organism": "Rat", "refseq_name": "proline-rich proteoglycan 2 precursor", "refseq_ac": [ { "id": "NP_742062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742062", "type": "external" } ], "gene_names_uniprotkb": "Prpg2; Prpmp5; Prb1", "gene_names_refseq": "Prb1; Prpg2; Prpmp5", "protein_names_uniprotkb": "Proline-rich proteoglycan 2; Acidic proline-rich protein PRP18", "protein_names_refseq": "acidic proline-rich protein PRP18; proline-rich protein BstNI subfamily 1; proline-rich proteoglycan 2 precursor; proline-rich proteoglycan 2", "tax_id": 10116, "disease": "", "pathway": " (rno:257651)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3840480;8376404", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07611", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32183-1", "uniprot_id": [ { "id": "FOXA3_RAT", "url": "https://www.uniprot.org/uniprot/P32183", "type": "external" } ], "mass": 37652.0, "length": 354, "protein_name": "Hepatocyte nuclear factor 3-gamma", "gene_name": "Foxa3", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 3-gamma isoform 1", "refseq_ac": [ { "id": "NP_058773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058773", "type": "external" } ], "gene_names_uniprotkb": "Foxa3; Hnf3g; Tcf-3g; Tcf3g", "gene_names_refseq": "Foxa3; Hnf3g", "protein_names_uniprotkb": "Hepatocyte nuclear factor 3-gamma; Forkhead box protein A3; HNF-3-gamma; HNF-3G", "protein_names_refseq": "HNF-3-gamma; HNF-3G; forkhead box protein A3; hepatocyte nuclear factor 3-gamma isoform 1; hepatocyte nuclear factor 3-gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:25100)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1672118;25896100;28358366;37528786;8332212;9369482", "class_list": "", "function": "Data suggested a protection role for Foxa3 during the progression of liver fibrosis in biliary atresia, and thereby supported increasing Foxa3 as a targeted treatment strategy. Publication Status: Online-Only, [RefSeq, PubMed]; FOXA3 and HNF4alpha are powerful transcription factors for inducing rat bone marrow mesenchymal stem cells to differentiate into functional hepatocyte-like cells., [RefSeq, PubMed]; Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis (By similarity)., [UniProtKB, PubMed]; [Combinational Overexpression of Foxa3 and Hnf4alpha Enhance the Proliferation and Prolong the Functional Maintenance of Primary Hepatocytes]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32183-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01713-1", "uniprot_id": [ { "id": "KLF9_RAT", "url": "https://www.uniprot.org/uniprot/Q01713", "type": "external" } ], "mass": 27155.0, "length": 244, "protein_name": "Krueppel-like factor 9", "gene_name": "Klf9", "organism": "Rat", "refseq_name": "Krueppel-like factor 9", "refseq_ac": [ { "id": "NP_476559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476559", "type": "external" } ], "gene_names_uniprotkb": "Klf9; Bteb1; Bteb", "gene_names_refseq": "Bteb1; Bteb; Klf9", "protein_names_uniprotkb": "Krueppel-like factor 9; BTE-binding protein 1; Basic transcription element-binding protein 1; GC-box-binding protein 1; Transcription factor BTEB1", "protein_names_refseq": "BTE-binding protein 1; GC-box-binding protein 1; Krueppel-like factor 9; Kruppel-like factor 9; basic transcription element-binding protein 1; transcription factor BTEB1", "tax_id": 10116, "disease": "", "pathway": " (rno:117560)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11953011;1356762;29860460;30315936;31295469;36109428;36359788", "class_list": "", "function": "Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells., [RefSeq, PubMed]; BTEB1 mediates the expression of growth-associated genes through direct and indirect transactivation mechanisms, one of which may involve the participation of a JNK family member., [RefSeq, PubMed]; High KLF9 expression is associated with ischemic injury in cardiomyocytes., [RefSeq, PubMed]; KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARgamma/NRF2 Signalling. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of Kruppel-Like Factor 9 Inhibits Aberrant Retinal Angiogenesis and Mitigates Proliferative Diabetic Retinopathy., [RefSeq, PubMed]; These results link intrinsic and extrinsic regulators of axon growth and suggest modulation of the KLF9-Dusp14 pathway as a potential approach to improve regeneration in the adult CNS after injury., [RefSeq, PubMed]; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990859 cellular response to endothelin;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q01713-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50480-1", "uniprot_id": [ { "id": "ISL2_RAT", "url": "https://www.uniprot.org/uniprot/P50480", "type": "external" } ], "mass": 39675.0, "length": 360, "protein_name": "Insulin gene enhancer protein ISL-2", "gene_name": "Isl2", "organism": "Rat", "refseq_name": "insulin gene enhancer protein ISL-2", "refseq_ac": [ { "id": "NP_065204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065204", "type": "external" } ], "gene_names_uniprotkb": "Isl2; Isl-2", "gene_names_refseq": "Isl2", "protein_names_uniprotkb": "Insulin gene enhancer protein ISL-2; Islet-2", "protein_names_refseq": "insulin gene enhancer protein ISL-2; insulin related protein 2 (islet 2); islet-2", "tax_id": 10116, "disease": "", "pathway": " (rno:57233)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10329173;7528105", "class_list": "", "function": "Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0021524 visceral motor neuron differentiation;GO:0007409 axonogenesis;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V801-1", "uniprot_id": [ { "id": "NETR_RAT", "url": "https://www.uniprot.org/uniprot/G3V801", "type": "external" } ], "mass": 84220.0, "length": 761, "protein_name": "Neurotrypsin", "gene_name": "Prss12", "organism": "Rat", "refseq_name": "neurotrypsin precursor", "refseq_ac": [ { "id": "NP_445956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445956", "type": "external" } ], "gene_names_uniprotkb": "Prss12", "gene_names_refseq": "Nt; Prss12", "protein_names_uniprotkb": "Neurotrypsin; 3.4.21.-; Serine protease 12", "protein_names_refseq": "neurotrypsin precursor; neurotrypsin; peptidase, serine, 12 (neurotrypsin, motopsin); protease, serine 12; protease, serine, 12 neurotrypsin (motopsin)", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 1 (Disease Ontology:DOID:0081177); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:85266)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18956887", "class_list": "", "function": "NMR structure of neurotrypsin kringle domain, [RefSeq, PubMed]; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q99JC8", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0006508 proteolysis;GO:0006887 exocytosis;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V801-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35819-1", "uniprot_id": [ { "id": "KLF6_RAT", "url": "https://www.uniprot.org/uniprot/O35819", "type": "external" } ], "mass": 31841.0, "length": 283, "protein_name": "Krueppel-like factor 6", "gene_name": "Klf6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klf6; Copeb", "gene_names_refseq": "", "protein_names_uniprotkb": "Krueppel-like factor 6; Core promoter element-binding protein; Transcription factor Zf9", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (rno:58954)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9689109", "class_list": "", "function": "Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8M5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1905205 positive regulation of connective tissue replacement;GO:1990859 cellular response to endothelin;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35819-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36374-1", "uniprot_id": [ { "id": "KLK6_RAT", "url": "https://www.uniprot.org/uniprot/P36374", "type": "external" } ], "mass": 29013.0, "length": 261, "protein_name": "Prostatic glandular kallikrein-6", "gene_name": "Klk1c8; Klk6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klk1c8; Klk6; Klk-8; Klk8", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostatic glandular kallikrein-6; 3.4.21.35; Glandular kallikrein-8; P1 kallikrein; Tissue kallikrein; rGK-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:292866); (R-RNO-381426)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2765531", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.35", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36374-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41232-1", "uniprot_id": [ { "id": "P2RY2_RAT", "url": "https://www.uniprot.org/uniprot/P41232", "type": "external" } ], "mass": 42137.0, "length": 374, "protein_name": "P2Y purinoceptor 2", "gene_name": "P2ry2", "organism": "Rat", "refseq_name": "P2Y purinoceptor 2", "refseq_ac": [ { "id": "NP_058951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058951", "type": "external" } ], "gene_names_uniprotkb": "P2ry2; P2ru1", "gene_names_refseq": "P2Y2; P2ry2", "protein_names_uniprotkb": "P2Y purinoceptor 2; ATP receptor; P2U purinoceptor 1; P2U1; P2Y2; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2U purinoceptor 1; P2U1; P2Y ATP receptor 2; P2Y purinoceptor 2; purinergic receptor P2Y, G-protein coupled, 2", "tax_id": 10116, "disease": "impotence (Disease Ontology:DOID:1875)", "pathway": " (rno:29597); (R-RNO-416476); (R-RNO-417957); (R-RNO-5683826); (R-RNO-9856530)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "31173231;32751703;34780922;35154311;38043889;7811468;9437211", "class_list": "", "function": "Downregulation of P2Y2 and HuD may partly be related to the development of the enteric nervous system in anorectal malformations embryos., [RefSeq, PubMed]; Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission., [RefSeq, PubMed]; P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy., [RefSeq, PubMed]; P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031686 A1 adenosine receptor binding;GO:0045030 G protein-coupled UTP receptor activity;GO:0005524 ATP binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P41232-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55067-1", "uniprot_id": [ { "id": "NCAN_RAT", "url": "https://www.uniprot.org/uniprot/P55067", "type": "external" } ], "mass": 135545.0, "length": 1257, "protein_name": "Neurocan core protein", "gene_name": "Ncan", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncan; Cspg3", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurocan core protein; 245 kDa early postnatal core glycoprotein; Chondroitin sulfate proteoglycan 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:58982); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101); (R-RNO-3000178)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "1326557;19576282;24090084;38843836;7513709", "class_list": "", "function": "May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 4, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 1, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 1, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0050804 modulation of chemical synaptic transmission;GO:0051823 regulation of synapse structural plasticity", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P55067-1", "record_type": "protein", "filter_code": "0000000.0001101.010000.000000000000001000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70605-1", "uniprot_id": [ { "id": "KCNN3_RAT", "url": "https://www.uniprot.org/uniprot/P70605", "type": "external" } ], "mass": 81448.0, "length": 732, "protein_name": "Small conductance calcium-activated potassium channel protein 3", "gene_name": "Kcnn3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnn3", "gene_names_refseq": "", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 3; KCa2.3; SK3; SKCa 3; SKCa3", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296); paranoid schizophrenia (Disease Ontology:DOID:1229); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:54263); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11245600;11533126;14559917;8781233", "class_list": "", "function": "Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11245600, PubMed:11533126). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:11245600, PubMed:11533126). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (PubMed:11533126). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11533126)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQ81;Q9ERQ4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044877 protein-containing complex binding;GO:0016286 small conductance calcium-activated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body;GO:0030175 filopodium", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70605-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35767-1", "uniprot_id": [ { "id": "NKX25_RAT", "url": "https://www.uniprot.org/uniprot/O35767", "type": "external" } ], "mass": 34336.0, "length": 318, "protein_name": "Homeobox protein Nkx-2.5", "gene_name": "Nkx2-5", "organism": "Rat", "refseq_name": "homeobox protein Nkx-2.5", "refseq_ac": [ { "id": "NP_446103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446103", "type": "external" } ], "gene_names_uniprotkb": "Nkx2-5; Csx; Nkx-2.5; Nkx2e", "gene_names_refseq": "Csx; Nkx2-5; Nkx2.5", "protein_names_uniprotkb": "Homeobox protein Nkx-2.5; Homeobox protein NK-2 homolog E; rNKx-2.5", "protein_names_refseq": "homeobox protein NK-2 homolog E; homeobox protein Nkx-2.5; rNKx-2.5", "tax_id": 10116, "disease": "atrioventricular block (Disease Ontology:DOID:0050820); congenital nongoitrous hypothyroidism 5 (Disease Ontology:DOID:0070125); aortic valve disease 2 (Disease Ontology:DOID:0080334); atrial heart septal defect 7 (Disease Ontology:DOID:0110112); ventricular septal defect (Disease Ontology:DOID:1657); heart septal defect (Disease Ontology:DOID:1681); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:114109)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31104268;32780729;33035436", "class_list": "", "function": "Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5., [RefSeq, PubMed]; Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The authors findings suggest that Nkx2.5, as a transcription factor, may be a regulatory element connecting different signaling pathways in response to oxidative stress and that reduced Nsd1 (Nuclear receptor-binding SET domain-containing protein 1) expression could lead to the alteration of global H3K36 and H4K20 methylation, influencing cardiac development., [RefSeq, PubMed]; Transcription factor required for the development of the heart and the spleen (By similarity). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0030878 thyroid gland development;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0003166 bundle of His development;GO:0003168 Purkinje myocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35767-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22273-1", "uniprot_id": [ { "id": "IL6RA_RAT", "url": "https://www.uniprot.org/uniprot/P22273", "type": "external" } ], "mass": 50401.0, "length": 462, "protein_name": "Interleukin-6 receptor subunit alpha", "gene_name": "Il6r", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il6r; Il6ra", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA", "protein_names_refseq": "", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); sleep apnea (Disease Ontology:DOID:0050847); developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); hyper IgE syndrome (Disease Ontology:DOID:0080545); non-syndromic X-linked intellectual disability 90 (Disease Ontology:DOID:0112041); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); Graves' disease (Disease Ontology:DOID:12361); Huntington's disease (Disease Ontology:DOID:12858); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162); orchitis (Disease Ontology:DOID:2518); pulmonary tuberculosis (Disease Ontology:DOID:2957); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24499); (R-RNO-1059683); (R-RNO-110056); (R-RNO-112411); (R-RNO-9958825)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "2174054", "class_list": "", "function": "Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory. Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (By similarity). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004915 interleukin-6 receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0019981 interleukin-6 binding;GO:0070119 ciliary neurotrophic factor binding", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005896 interleukin-6 receptor complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010332 response to gamma radiation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22273-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57790-1", "uniprot_id": [ { "id": "KEAP1_RAT", "url": "https://www.uniprot.org/uniprot/P57790", "type": "external" } ], "mass": 69399.0, "length": 624, "protein_name": "Kelch-like ECH-associated protein 1", "gene_name": "Keap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Keap1; Inrf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; INrf2", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); gallbladder cancer (Disease Ontology:DOID:3121); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:117519); (R-RNO-5689880); (R-RNO-8951664); (R-RNO-9755511); (R-RNO-983168)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "11439354", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes. In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2. The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERI3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0097718 disordered domain specific binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0010506 regulation of autophagy;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P57790-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70512-1", "uniprot_id": [ { "id": "HNF6_RAT", "url": "https://www.uniprot.org/uniprot/P70512", "type": "external" } ], "mass": 51067.0, "length": 465, "protein_name": "Hepatocyte nuclear factor 6", "gene_name": "Onecut1", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 6", "refseq_ac": [ { "id": "NP_073162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073162", "type": "external" } ], "gene_names_uniprotkb": "Onecut1; Hnf6a; Hnf6", "gene_names_refseq": "Hnf6; Onecut1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 6; HNF-6; One cut domain family member 1; One cut homeobox 1", "protein_names_refseq": "HNF-6; hepatocyte nuclear factor 6; one cut domain, family member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25231)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "33222081;8790352;8887657;9593691", "class_list": "", "function": "Liver Macrophages Stimulate the Expression of Hepatocyte Nuclear Factor-6 and Promote Hepatocyte Proliferation at the Early Stage of Liver Regeneration., [RefSeq, PubMed]; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. The affinity of HNF-6-alpha and HNF-6-beta for DNA differs depending on the target sequence., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88755", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70512-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42264-1", "uniprot_id": [ { "id": "GRIK3_RAT", "url": "https://www.uniprot.org/uniprot/P42264", "type": "external" } ], "mass": 104071.0, "length": 919, "protein_name": "Glutamate receptor ionotropic, kainate 3", "gene_name": "Grik3", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, kainate 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106187", "type": "external" } ], "gene_names_uniprotkb": "Grik3; Glur7", "gene_names_refseq": "GluK3; GluR7; Grik3; gluR-7", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 3; GluK3; GluR-7; GluR7; Glutamate receptor 7", "protein_names_refseq": "glutamate receptor 7; glutamate receptor ionotropic, kainate 3 isoform 1 precursor; glutamate receptor subunit kainate subtype; glutamate receptor, ionotropic, kainate 3", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:298521); (R-RNO-451308); (R-RNO-500657)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10023812;11122333;1322826;1371217;19217376;20951142;21907808;23141068;24090084;24264036;31311973;38843836;9390526", "class_list": "", "function": "Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Compared to other kainate or AMPA receptors, this subunit exhibits a lower sensitivity to glutamate, and thus may play a unique role in neurotransmission in the brain. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:1322826, PubMed:1371217, PubMed:21907808). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and the glutamatergic agonist kainic acid., [UniProtKB, PubMed]; Our results suggest that mGluR2 and mGluR7 may contribute to the early rebalancing of spontaneous resting activity in the MVN Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Publication Status: Online-Only, [RefSeq, PubMed]; Zinc binding stabilizes the labile GluK3 dimer interface, slows desensitization and potentiates currents., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "O35420", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0004970 glutamate-gated receptor activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043195 terminal bouton", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P42264-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52190-1", "uniprot_id": [ { "id": "KCNJ4_RAT", "url": "https://www.uniprot.org/uniprot/P52190", "type": "external" } ], "mass": 49690.0, "length": 446, "protein_name": "Inward rectifier potassium channel 4", "gene_name": "Kcnj4", "organism": "Rat", "refseq_name": "inward rectifier potassium channel 4", "refseq_ac": [ { "id": "NP_446322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446322", "type": "external" } ], "gene_names_uniprotkb": "Kcnj4; Irk3", "gene_names_refseq": "Hirk2; Kcnj4", "protein_names_uniprotkb": "Inward rectifier potassium channel 4; BIR11; Brain inwardly rectifying K(+) channel 2; IRK-3; Inward rectifier K(+) channel Kir2.3; Potassium channel, inwardly rectifying subfamily J member 4", "protein_names_refseq": "BIR11; IRK-3; IRK3; brain inwardly rectifying K(+) channel 2; inward rectifier K(+) channel Kir2.3; inward rectifier potassium channel 4; potassium channel, inwardly rectifying subfamily J member 4; potassium voltage-gated channel subfamily J member 4", "tax_id": 10116, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (rno:116649); (R-RNO-1296041); (R-RNO-1296053); (R-RNO-5576886); (R-RNO-997272)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "14960569;16855024;17670900;18619942;23426663;23561319;7624316;7796907;7874445", "class_list": "", "function": "Down-regulation of the Kir2.3 channel expression contributes to the pathogenesis of temporal lobe epilepsy., [RefSeq, PubMed]; Immunochemical staining verified that both pericytes and endothelial cells of descending vasa recta express K(IR)2.1, K(IR)2.2, and K(IR)2.3 subunits., [RefSeq, PubMed]; Immunohistochemical analysis reveals the expression of Kir2.1, Kir2.2, and Kir2.3/Kcnj4 within spontaneously bursting neurons that regulate the level of pacemaker activity within the developing superficial dorsal horn., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium., [UniProtKB, PubMed, PubMed]; These studies provide an entry point for understanding the novel roles of Kir2.3 in cell models of PD, and they offer clues for the common mechanisms underlying different neurodegenerative conditions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35752", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071260 cellular response to mechanical stimulus;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54912-1", "uniprot_id": [ { "id": "KCNK3_RAT", "url": "https://www.uniprot.org/uniprot/O54912", "type": "external" } ], "mass": 45276.0, "length": 411, "protein_name": "Potassium channel subfamily K member 3", "gene_name": "Kcnk3", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 3", "refseq_ac": [ { "id": "NP_203694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203694", "type": "external" } ], "gene_names_uniprotkb": "Kcnk3; Task1; Task", "gene_names_refseq": "Kcnk3; Task-1; rTASK", "protein_names_uniprotkb": "Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1", "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; acid-sensitive potassium channel protein TASK-1; potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; two pore K(+) channel KT3.1; two pore potassium channel KT3.1", "tax_id": 10116, "disease": "primary pulmonary hypertension (Disease Ontology:DOID:14557); status epilepticus (Disease Ontology:DOID:1824); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:29553); (R-RNO-1299316); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10725353;12122143;14678492;15282272;33010302;33483721;34073580;34571371;37338577;9437008", "class_list": "", "function": "Characterization in cerebellar granule neurons, [RefSeq, PubMed]; Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary arterial smooth muscle cell proliferation by regulating KCNK3 expression., [RefSeq, PubMed]; Exploring the involvement of TASK-1 in the control of isolated rat right atrium function from healthy animals and an experimental model of monocrotaline-induced pulmonary hypertension., [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:10725353, PubMed:15282272, PubMed:9437008). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity) (PubMed:15282272). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In cerebellar granule cells, heteromeric KCNK3:KCNK9 channel may hyperpolarize the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, it may support high-frequency action potential firing and increased neuronal excitability (By similarity) (PubMed:14678492). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex. Additionally, imparts chemosensitivity to type 1 cells in carotid bodies which respond to a decrease in arterial oxygen pressure or an increase in carbon dioxide pressure or pH to initiate adaptive changes in pulmonary ventilation (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity). In brown adipocytes, mediates K(+) efflux that counteracts norepinephrine-induced membrane depolarization, limits Ca(2+) efflux and downstream cAMP and PKA signaling, ultimately attenuating lipid oxidation and adaptive thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload., [RefSeq, PubMed]; Restoration of Vitamin D Levels Improves Endothelial Function and Increases TASK-Like K(+) Currents in Pulmonary Arterial Hypertension Associated with Vitamin D Deficiency. Publication Status: Online-Only, [RefSeq, PubMed]; TASK-1 regulates mitochondrial function under hypoxia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0005216 monoatomic ion channel activity;GO:0046982 protein heterodimerization activity;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0003029 detection of hypoxic conditions in blood by carotid body chemoreceptor signaling;GO:0034220 monoatomic ion transmembrane transport;GO:0071456 cellular response to hypoxia;GO:0006813 potassium ion transport;GO:1903818 positive regulation of voltage-gated potassium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54912-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08618-1", "uniprot_id": [ { "id": "KPRB_RAT", "url": "https://www.uniprot.org/uniprot/O08618", "type": "external" } ], "mass": 40867.0, "length": 369, "protein_name": "Phosphoribosyl pyrophosphate synthase-associated protein 2", "gene_name": "Prpsap2", "organism": "Rat", "refseq_name": "phosphoribosyl pyrophosphate synthase-associated protein 2", "refseq_ac": [ { "id": "NP_476472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476472", "type": "external" } ], "gene_names_uniprotkb": "Prpsap2", "gene_names_refseq": "Pap41; Prpsap2", "protein_names_uniprotkb": "Phosphoribosyl pyrophosphate synthase-associated protein 2; 41 kDa phosphoribosypyrophosphate synthetase-associated protein; PAP41; PRPP synthase-associated protein 2", "protein_names_refseq": "41 kDa phosphoribosypyrophosphate synthetase-associated protein; PRPP synthase-associated protein 2; PRPP synthetase-associated protein 2; phosphoribosyl pyrophosphate synthase-associated protein 2", "tax_id": 10116, "disease": "X-linked nonsyndromic deafness (Disease Ontology:DOID:0050566); Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210)", "pathway": " (rno:117272)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9003449", "class_list": "", "function": "Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060348 bone development;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08618-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08776-1", "uniprot_id": [ { "id": "NDUF3_RAT", "url": "https://www.uniprot.org/uniprot/O08776", "type": "external" } ], "mass": 20696.0, "length": 185, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3", "gene_name": "Ndufaf3", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform b", "refseq_ac": [ { "id": "NP_001029143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029143", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf3", "gene_names_refseq": "Ndufaf3; RGD708545", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Nuclear protein E3-3", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3; NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform b; nuclear protein E3-3", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 18 (Disease Ontology:DOID:0112070)", "pathway": " (rno:56769); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9349717", "class_list": "", "function": "Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)., [UniProtKB]; This gene encodes a protein that is required for assembly of mitochondrial NADH: ubiquinone oxidoreductase complex I, a multiprotein enzyme complex that is part of the oxidative phosphorylation pathway. In humans, mutations in this gene are associated with fatal neonatal mitochondrial disease and lactic acidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08777;Q6AXV1;Q78E24", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O08776-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35162-1", "uniprot_id": [ { "id": "HSP13_RAT", "url": "https://www.uniprot.org/uniprot/O35162", "type": "external" } ], "mass": 51795.0, "length": 471, "protein_name": "Heat shock 70 kDa protein 13", "gene_name": "Hspa13", "organism": "Rat", "refseq_name": "heat shock 70 kDa protein 13 precursor", "refseq_ac": [ { "id": "NP_062144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062144", "type": "external" } ], "gene_names_uniprotkb": "Hspa13; Stch", "gene_names_refseq": "Hspa13; Stch", "protein_names_uniprotkb": "Heat shock 70 kDa protein 13; Microsomal stress-70 protein ATPase core; Stress-70 protein chaperone microsome-associated 60 kDa protein", "protein_names_refseq": "heat shock 70 kDa protein 13 precursor; heat shock 70 kDa protein 13; heat shock protein 13; heat shock protein 70 family, member 13; heat shock protein 70kDa family, member 13; microsomal stress-70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kD human homolog; stress 70 protein chaperone, microsome-associated, human homolog; stress-70 protein chaperone microsome-associated 60 kDa protein", "tax_id": 10116, "disease": "fragile X-associated tremor/ataxia syndrome (Disease Ontology:DOID:0050879); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); primary ovarian insufficiency 1 (Disease Ontology:DOID:0080857); fragile X syndrome (Disease Ontology:DOID:14261); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (rno:29734); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "24090084;8131751;9358068", "class_list": "", "function": "Has peptide-independent ATPase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRE1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35162-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35543-1", "uniprot_id": [ { "id": "HPGDS_RAT", "url": "https://www.uniprot.org/uniprot/O35543", "type": "external" } ], "mass": 23297.0, "length": 199, "protein_name": "Hematopoietic prostaglandin D synthase", "gene_name": "Hpgds", "organism": "Rat", "refseq_name": "hematopoietic prostaglandin D synthase", "refseq_ac": [ { "id": "NP_113832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113832", "type": "external" } ], "gene_names_uniprotkb": "Hpgds; Gsts; Pgds; Ptgds2", "gene_names_refseq": "Hpgds; Ptgds2", "protein_names_uniprotkb": "Hematopoietic prostaglandin D synthase; 2.5.1.18; 5.3.99.2; GST class-sigma; Glutathione S-transferase; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; H-PGDS; Prostaglandin-H2 D-isomerase", "protein_names_refseq": "GST class-sigma; H-PGDS; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; hematopoietic prostaglandin D synthase; prostaglandin D2 synthase 2, hematopoietic; prostaglandin-H2 D-isomerase", "tax_id": 10116, "disease": "allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:58962); (R-RNO-156590); (R-RNO-2162123)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10871602;11672424;12684506;16547010;17259069;29393594;9323136", "class_list": "", "function": "Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; L-PGDS is involved in the balance of VSMC proliferation and apoptosis, [RefSeq, PubMed]; Post-translational modification of L-PGDS, by either glycosylation or phosphorylation, enhances its apoptotic activity and inhibits vascular smooth muscle cells hyperproliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35351", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0004364 glutathione transferase activity;GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0006693 prostaglandin metabolic process;GO:0010269 response to selenium ion;GO:0019371 cyclooxygenase pathway;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35543-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35762-1", "uniprot_id": [ { "id": "NKX61_RAT", "url": "https://www.uniprot.org/uniprot/O35762", "type": "external" } ], "mass": 37689.0, "length": 365, "protein_name": "Homeobox protein Nkx-6.1", "gene_name": "Nkx6-1", "organism": "Rat", "refseq_name": "homeobox protein Nkx-6.1", "refseq_ac": [ { "id": "NP_113925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113925", "type": "external" } ], "gene_names_uniprotkb": "Nkx6-1; Nkx6.1; Nkx6a", "gene_names_refseq": "Nkx6-1; Nkx6.1; Nkx61; Nkx6a", "protein_names_uniprotkb": "Homeobox protein Nkx-6.1; Homeobox protein NK-6 homolog A", "protein_names_refseq": "NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related, locus 1; homeobox protein NK-6 homolog A; homeobox protein Nkx-6.1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65193)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10567713;25285789;26030060;27164028;29142323;36639413", "class_list": "", "function": "Deficiency of transcription factor Nkx6.1 does not prevent insulin secretion in INS-1E cells. Publication Status: Online-Only, [RefSeq, PubMed]; Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord. Publication Status: Online-Only, [RefSeq, PubMed]; The beta-cell maintenance factor Nkx6.1 mRNA and protein were declining with age (>12-fold, 10 months) and decreasing with fasting hyperglycemia in Goto Kakizaki rats, probably predetermining the impaired mtDNA replication (copy number decrease), while spatial expansion of mtDNA kept nucleoids with only smaller sizes than those containing much higher mtDNA in non-diabetic beta-cells. Publication Status: Online-Only, [RefSeq, PubMed]; The homeobox beta-cell transcription factor Nkx6.1 induces beta-cell proliferation by activating the orphan nuclear receptors Nr4a1 and Nr4a3., [RefSeq, PubMed]; These data demonstrate that c-Fos is critical for Nkx6.1-mediated expansion of functional beta-cell mass., [RefSeq, PubMed]; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35762-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35776-1", "uniprot_id": [ { "id": "HYAS2_RAT", "url": "https://www.uniprot.org/uniprot/O35776", "type": "external" } ], "mass": 63534.0, "length": 552, "protein_name": "Hyaluronan synthase 2", "gene_name": "Has2", "organism": "Rat", "refseq_name": "hyaluronan synthase 2", "refseq_ac": [ { "id": "NP_037285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037285", "type": "external" } ], "gene_names_uniprotkb": "Has2", "gene_names_refseq": "Has2", "protein_names_uniprotkb": "Hyaluronan synthase 2; 2.4.1.212; HA synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2", "protein_names_refseq": "HA synthase 2; hyaluronan synthase 2; hyaluronate synthase 2; hyaluronic acid synthase 2", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (rno:25694); (R-RNO-2142845)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12784612;25499520;27094859", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expression patterns of Has and Hyal genes differed between normal, acute-scarred, and chronic-scarred vocal folds, indicating the distinct roles of each enzyme in maintaining HA., [RefSeq, PubMed]; Hyaluronan biosynthesis, by way of HAS2, is required for the retention of aggrecan., [RefSeq, PubMed]; Protein malnutrition has a primary impact on the gene expression of Has2 and Has3, which leads to the reduction of hyaluronan content and to disfunction of the skin, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0001570 vasculogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35776-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35799-1", "uniprot_id": [ { "id": "HFE_RAT", "url": "https://www.uniprot.org/uniprot/O35799", "type": "external" } ], "mass": 40988.0, "length": 360, "protein_name": "Hereditary hemochromatosis protein homolog", "gene_name": "Hfe", "organism": "Rat", "refseq_name": "hereditary hemochromatosis protein homolog isoform 1 precursor", "refseq_ac": [ { "id": "NP_445753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445753", "type": "external" } ], "gene_names_uniprotkb": "Hfe", "gene_names_refseq": "Hfe", "protein_names_uniprotkb": "Hereditary hemochromatosis protein homolog; RT1-CAFE", "protein_names_refseq": "RT1-CAFE; hereditary hemochromatosis protein homolog isoform 1 precursor; hereditary hemochromatosis protein homolog", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); alcohol-associated liver disease (Disease Ontology:DOID:0070658); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hemochromatosis type 1 (Disease Ontology:DOID:0111029); Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); dilated cardiomyopathy (Disease Ontology:DOID:12930); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); hemochromatosis (Disease Ontology:DOID:2352); ovarian cancer (Disease Ontology:DOID:2394); porphyria cutanea tarda (Disease Ontology:DOID:3132); liver disease (Disease Ontology:DOID:409); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); intestinal obstruction (Disease Ontology:DOID:8437); polymyalgia rheumatica (Disease Ontology:DOID:853); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); polycythemia vera (Disease Ontology:DOID:8997); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29199); (R-RNO-917977)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21454685", "class_list": "", "function": "Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35175", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0039706 co-receptor binding;GO:1990459 transferrin receptor binding;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0045178 basal part of cell", "go_biological_process": "GO:0002725 negative regulation of T cell cytokine production;GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0006879 intracellular iron ion homeostasis;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35799-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35811-1", "uniprot_id": [ { "id": "P2RY4_RAT", "url": "https://www.uniprot.org/uniprot/O35811", "type": "external" } ], "mass": 40894.0, "length": 361, "protein_name": "P2Y purinoceptor 4", "gene_name": "P2ry4", "organism": "Rat", "refseq_name": "P2Y purinoceptor 4", "refseq_ac": [ { "id": "NP_113868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113868", "type": "external" } ], "gene_names_uniprotkb": "P2ry4; P2y4", "gene_names_refseq": "P2Y4; P2ry4", "protein_names_uniprotkb": "P2Y purinoceptor 4; P2Y4", "protein_names_refseq": "P2Y ATP receptor 4; P2Y purinoceptor 4; purinergic receptor P2Y, G-protein coupled 4; pyrimidinergic receptor P2Y, G-protein coupled, 4", "tax_id": 10116, "disease": "", "pathway": " (rno:63843); (R-RNO-417957); (R-RNO-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "24771361;28468962;33122160;36591760;9751165", "class_list": "", "function": "Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats., [RefSeq, PubMed]; Extracellular ATP modulates podocyte function through P2Y purinergic receptors and pleiotropic effects on AMPK and cAMP/PKA signaling pathways., [RefSeq, PubMed]; IN VIVO ACTIVATION OF P2Y4 PURINERGIC RECEPTORS USING ATP IN RAT EPIDERMAL TISSUE., [RefSeq, PubMed]; In 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups, [RefSeq, PubMed]; Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ADP or UDP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045030 G protein-coupled UTP receptor activity;GO:0005524 ATP binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0071380 cellular response to prostaglandin E stimulus;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0030321 transepithelial chloride transport;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35811-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70150-1", "uniprot_id": [ { "id": "KCC1B_RAT", "url": "https://www.uniprot.org/uniprot/O70150", "type": "external" } ], "mass": 38439.0, "length": 343, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1B", "gene_name": "Pnck", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1B", "refseq_ac": [ { "id": "NP_058971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058971", "type": "external" } ], "gene_names_uniprotkb": "Pnck", "gene_names_refseq": "Camk1b; Pnck", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1B; 2.7.11.17; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog", "protein_names_refseq": "Protein Kinase-like; caM kinase I beta; caM kinase IB; caM-KI beta; caMKI-beta; calcium/calmodulin-dependent protein kinase 1, beta; calcium/calmodulin-dependent protein kinase type 1B; pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog; pregnancy upregulated non-ubiquitously expressed CaM kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:29660)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11705382;22673903;9074610;9405489", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro, isoform 1 and isoform 2 phosphorylate CREB1, SYN1/synapsin I. Phosphorylates and activates CAMK1., [UniProtKB, PubMed]; Residues 129-151 of recombinant CaM-KK beta participate in the release of the autoinhibitory domain from its catalytic core, resulting in generation of autonomous activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08767", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70150-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70453-1", "uniprot_id": [ { "id": "HMOX3_RAT", "url": "https://www.uniprot.org/uniprot/O70453", "type": "external" } ], "mass": 32592.0, "length": 290, "protein_name": "Putative heme oxygenase 3", "gene_name": "Hmox3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hmox3", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative heme oxygenase 3; 1.14.14.18; HO-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15246535;9266719", "class_list": "", "function": "Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Heme oxygenase 3 could be implicated in some heme-dependent regulatory role in the cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042167 heme catabolic process;GO:0006788 heme oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70453-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70540-1", "uniprot_id": [ { "id": "MADCA_RAT", "url": "https://www.uniprot.org/uniprot/O70540", "type": "external" } ], "mass": 42507.0, "length": 394, "protein_name": "Mucosal addressin cell adhesion molecule 1", "gene_name": "Madcam1", "organism": "Rat", "refseq_name": "mucosal addressin cell adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_062190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062190", "type": "external" } ], "gene_names_uniprotkb": "Madcam1", "gene_names_refseq": "Madcam1", "protein_names_uniprotkb": "Mucosal addressin cell adhesion molecule 1; MAdCAM-1; rMAdCAM-1", "protein_names_refseq": "MAdCAM-1; mucosal addressin cell adhesion molecule 1 precursor; mucosal addressin cell adhesion molecule 1; rMAdCAM-1", "tax_id": 10116, "disease": "food allergy (Disease Ontology:DOID:3044); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:54266); (R-RNO-198933); (R-RNO-216083)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12034298;16387148;9512658", "class_list": "", "function": "Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity)., [UniProtKB]; During small bowel allograft rejection., FTY720 was found to prevent the down-regulation of MAdCAM-1 expression in endothelial venules, [RefSeq, PubMed]; Immunohistochemical analysis of MAdCAM-1 expression during acute rejection on small bowel grafts in rats, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098640 integrin binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion;GO:0030216 keratinocyte differentiation;GO:0050900 leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70540-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70596-1", "uniprot_id": [ { "id": "KCJ14_RAT", "url": "https://www.uniprot.org/uniprot/O70596", "type": "external" } ], "mass": 47609.0, "length": 434, "protein_name": "ATP-sensitive inward rectifier potassium channel 14", "gene_name": "Kcnj14", "organism": "Rat", "refseq_name": "ATP-sensitive inward rectifier potassium channel 14", "refseq_ac": [ { "id": "NP_733836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733836", "type": "external" } ], "gene_names_uniprotkb": "Kcnj14; Irk4", "gene_names_refseq": "IRK4; Kcnj14; Kir2.4", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 14; IRK-4; Inward rectifier K(+) channel Kir2.4; Potassium channel, inwardly rectifying subfamily J member 14", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 14; inward rectifier K(+) channel Kir2.4; inwardly rectifying potassium channel Kir2.4; potassium channel, inwardly rectifying subfamily J member 14; potassium inwardly-rectifying channel J14; potassium voltage-gated channel subfamily J member 14", "tax_id": 10116, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (rno:276720); (R-RNO-1296053); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9592090", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70596-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70617-1", "uniprot_id": [ { "id": "KCJ13_RAT", "url": "https://www.uniprot.org/uniprot/O70617", "type": "external" } ], "mass": 40637.0, "length": 360, "protein_name": "Inward rectifier potassium channel 13", "gene_name": "Kcnj13", "organism": "Rat", "refseq_name": "inward rectifier potassium channel 13", "refseq_ac": [ { "id": "NP_446060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446060", "type": "external" } ], "gene_names_uniprotkb": "Kcnj13", "gene_names_refseq": "Kcnj13; Kir7.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 13; Inward rectifier K(+) channel Kir7.1; Potassium channel, inwardly rectifying subfamily J member 13", "protein_names_refseq": "inward rectifier K(+) channel Kir7.1; inward rectifier potassium channel 13; potassium channel, inwardly rectifying subfamily J member 13; potassium voltage-gated channel subfamily J member 13", "tax_id": 10116, "disease": "Leber congenital amaurosis 16 (Disease Ontology:DOID:0110118); snowflake vitreoretinal degeneration (Disease Ontology:DOID:0111570); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (rno:94341)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10871613;11042260;12631077;16406822;23255580;26402555;37318990", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Kir7.1 is expressed in epithelial cells all along the respiratory tree. Publication Status: Online-Only, [RefSeq, PubMed]; Kir7.1 is involved in the development of renal K+ excretion between 14 and 21 days after birth under the condition of K+ overload., [RefSeq, PubMed]; Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats., [RefSeq, PubMed]; Mutant subunits did not alter Kir7.1 channel selectivity., [RefSeq, PubMed]; Results suggest that the C-terminal length plays an important role in the plasma-membrane localization of Kir7.1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:1990573 potassium ion import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70617-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88177-1", "uniprot_id": [ { "id": "PEX12_RAT", "url": "https://www.uniprot.org/uniprot/O88177", "type": "external" } ], "mass": 40681.0, "length": 359, "protein_name": "Peroxisome assembly protein 12", "gene_name": "Pex12", "organism": "Rat", "refseq_name": "peroxisome assembly protein 12", "refseq_ac": [ { "id": "NP_446373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446373", "type": "external" } ], "gene_names_uniprotkb": "Pex12; Paf3", "gene_names_refseq": "Pex12", "protein_names_uniprotkb": "Peroxisome assembly protein 12; PAF-3; Peroxin-12; Peroxisome assembly factor 3", "protein_names_refseq": "PAF-3; peroxin-12; peroxisome assembly factor 3; peroxisome assembly protein 12-like; peroxisome assembly protein 12", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 3A (Disease Ontology:DOID:0080478); peroxisome biogenesis disorder 3B (Disease Ontology:DOID:0081241)", "pathway": " (rno:116718); (R-RNO-8866654); (R-RNO-9033241); (R-RNO-9603798)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "9354782;9632816", "class_list": "", "function": "Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0007031 peroxisome organization;GO:0000209 protein polyubiquitination;GO:0034614 cellular response to reactive oxygen species;GO:0016558 protein import into peroxisome matrix;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88177-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88426-1", "uniprot_id": [ { "id": "NDK6_RAT", "url": "https://www.uniprot.org/uniprot/O88426", "type": "external" } ], "mass": 21340.0, "length": 186, "protein_name": "Nucleoside diphosphate kinase 6, mitochondrial", "gene_name": "Nme6", "organism": "Rat", "refseq_name": "nucleoside diphosphate kinase 6, mitochondrial", "refseq_ac": [ { "id": "NP_001178813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178813", "type": "external" } ], "gene_names_uniprotkb": "Nme6", "gene_names_refseq": "NDK6; Nm23-R6; Nme6", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 6, mitochondrial; 2.7.4.6; NDK6; NDP kinase 6; nm23-R6", "protein_names_refseq": "NDK 6; NDP kinase 6; expressed in non-metastatic cells 6 (nucleoside-diphosphate kinase); expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase); non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 6, mitochondrial; nucleoside diphosphate kinase 6; nucleoside diphosphate kinase type 6", "tax_id": 10116, "disease": "", "pathway": " (rno:58964); (R-RNO-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10453732", "class_list": "", "function": "Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "R9PXW5", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0030308 negative regulation of cell growth;GO:0045839 negative regulation of mitotic nuclear division;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88426-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88758-1", "uniprot_id": [ { "id": "KCNS1_RAT", "url": "https://www.uniprot.org/uniprot/O88758", "type": "external" } ], "mass": 54915.0, "length": 497, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS1", "gene_name": "Kcns1", "organism": "Rat", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS1", "refseq_ac": [ { "id": "NP_446406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446406", "type": "external" } ], "gene_names_uniprotkb": "Kcns1", "gene_names_refseq": "Kcns1; Kv9.1", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS1; Delayed-rectifier K(+) channel alpha subunit 1; Delayed-rectifier potassium channel subunit Kv9.1; Potassium voltage-gated channel modifier subfamily S member 1", "protein_names_refseq": "K+ voltage-gated channel, subfamily S, 1; delayed-rectifier K(+) channel alpha subunit 1; delayed-rectifier potassium channel regulatory subunit KCNS1; delayed-rectifier potassium channel subunit Kv9.1; potassium voltage-gated channel subfamily S member 1; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; voltage-gated potassium channel subunit Kv9.1", "tax_id": 10116, "disease": "intracranial hypertension (Disease Ontology:DOID:9428)", "pathway": " (rno:117023); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "23197740;9704029", "class_list": "", "function": "Our results demonstrate that Kv9.1 dysfunction leads to spontaneous and evoked neuronal hyperexcitability in myelinated fibers, coupled with development of neuropathic pain behaviors., [RefSeq, PubMed]; Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (By similarity). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88758-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88794-1", "uniprot_id": [ { "id": "PNPO_RAT", "url": "https://www.uniprot.org/uniprot/O88794", "type": "external" } ], "mass": 30184.0, "length": 261, "protein_name": "Pyridoxine-5'-phosphate oxidase", "gene_name": "Pnpo", "organism": "Rat", "refseq_name": "pyridoxine-5'-phosphate oxidase", "refseq_ac": [ { "id": "NP_072123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072123", "type": "external" } ], "gene_names_uniprotkb": "Pnpo", "gene_names_refseq": "Pnpo", "protein_names_uniprotkb": "Pyridoxine-5'-phosphate oxidase; 1.4.3.5; Pyridoxamine-phosphate oxidase", "protein_names_refseq": "pyridoxamine-phosphate oxidase; pyridoxine 5-phosphate oxidase; pyridoxine-5'-phosphate oxidase", "tax_id": 10116, "disease": "pyridoxamine 5'-phosphate oxidase deficiency (Disease Ontology:DOID:0111329); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:64533); (R-RNO-964975)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14697241;18680158;22673903;29393594;9601034", "class_list": "", "function": "Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)., [UniProtKB, PubMed]; PNPO may play a role in activity-dependent regulation of PLP level in the brain, which is involved in LTP induction and paired-pulse facilitation but not in enhancement of GABAergic inhibition., [RefSeq, PubMed]; Pnpo is a candidate gene responsible for hypertension in Dahl-S rats, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.5", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0010181 FMN binding;GO:0004733 pyridoxamine phosphate oxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042816 vitamin B6 metabolic process;GO:0008615 pyridoxine biosynthetic process;GO:0042823 pyridoxal phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88902-1", "uniprot_id": [ { "id": "PTN23_RAT", "url": "https://www.uniprot.org/uniprot/O88902", "type": "external" } ], "mass": 163454.0, "length": 1499, "protein_name": "Tyrosine-protein phosphatase non-receptor type 23", "gene_name": "Ptpn23", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptpn23", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 23; 3.1.3.48; HD-PTP; His domain-containing protein tyrosine phosphatase; PTP-TD14; Protein tyrosine phosphatase TD14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:117552)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11095967;18683930;22673903;38843836;9694860", "class_list": "", "function": "Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZP8", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1903393 positive regulation of adherens junction organization;GO:0045022 early endosome to late endosome transport;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88902-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89047-1", "uniprot_id": [ { "id": "KCNH3_RAT", "url": "https://www.uniprot.org/uniprot/O89047", "type": "external" } ], "mass": 117580.0, "length": 1087, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH3", "gene_name": "Kcnh3", "organism": "Rat", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH3", "refseq_ac": [ { "id": "NP_058804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058804", "type": "external" } ], "gene_names_uniprotkb": "Kcnh3; Elk2", "gene_names_refseq": "Bec1; Elk2; Kcnh3", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH3; BEC1; Brain-specific eag-like channel 1; ELK channel 2; Ether-a-go-go-like potassium channel 2; Potassium voltage-gated channel subfamily H member 3; Voltage-gated potassium channel subunit Kv12.2; rElk2", "protein_names_refseq": "ELK channel 2; brain-specific eag-like channel 1; ether-a-go-go-like potassium channel 2; potassium channel, voltage gated eag related subfamily H, member 3; potassium voltage-gated channel, subfamily H (eag-related), member 3; rElk2; voltage-gated inwardly rectifying potassium channel KCNH3; voltage-gated potassium channel subunit Kv12.2", "tax_id": 10116, "disease": "", "pathway": " (rno:27150); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10455180;10718922;29393594;9714851;9824707", "class_list": "", "function": "Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel (PubMed:9824707). Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism (PubMed:9824707). Exhibits a rapid recovery from inactivation (PubMed:9824707)., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O89047-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01048-1", "uniprot_id": [ { "id": "KNT1_RAT", "url": "https://www.uniprot.org/uniprot/P01048", "type": "external" } ], "mass": 47775.0, "length": 430, "protein_name": "T-kininogen 1", "gene_name": "Map1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Map1", "gene_names_refseq": "", "protein_names_uniprotkb": "T-kininogen 1; Alpha-1-MAP; Major acute phase protein; T-kininogen I heavy chain; T-kininogen I light chain; T-kininogen I; Thiostatin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 12, "publication_id_list": "1575697;2108948;2413018;2439509;2578992;2806908;3029068;3121623;3335530;3818598;7574705;7947964", "class_list": "", "function": "Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the active peptide bradykinin they effect smooth muscle contraction, induction of hypotension and increase of vascular permeability. (2) They play a role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of thiol proteases., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 11, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P04081;Q6LDW3", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043204 perikaryon", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0043410 positive regulation of MAPK cascade;GO:0052548 regulation of endopeptidase activity;GO:0006953 acute-phase response;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P01048-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01179-1", "uniprot_id": [ { "id": "NEU1_RAT", "url": "https://www.uniprot.org/uniprot/P01179", "type": "external" } ], "mass": 12823.0, "length": 125, "protein_name": "Oxytocin-neurophysin 1", "gene_name": "Oxt", "organism": "Rat", "refseq_name": "oxytocin-neurophysin 1 preproprotein", "refseq_ac": [ { "id": "NP_037128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037128", "type": "external" } ], "gene_names_uniprotkb": "Oxt; Ot", "gene_names_refseq": "Oxt", "protein_names_uniprotkb": "Oxytocin-neurophysin 1; OT-NPI; Ocytocin; pro-OXT; pro-oxytocin/neurophysin", "protein_names_refseq": "OT-NPI; oxcytocin; oxytocin, prepropeptide; oxytocin-neurophysin 1 preproprotein; oxytocin-neurophysin 1; oxytocin/neurophysin (Oxt) gene, complete gene, complete cds; oxytocin/neurophysin 1 prepropeptide", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); myelodysplastic syndrome (Disease Ontology:DOID:0050908); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); osteosarcoma (Disease Ontology:DOID:3347); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); pulmonary emphysema (Disease Ontology:DOID:9675); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:25504); (R-RNO-388479); (R-RNO-416476)", "pathway_count": 3, "publication_count": 20, "publication_id_list": "1371278;1706187;17170309;17925443;21719680;3203740;36130511;36868221;3768139;38642676;39088908;39407302;5150741;6153132;6326097;65791;7036996;7238864;891987;9523585", "class_list": "", "function": "An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow., [RefSeq, PubMed]; Carrier protein that binds to and transports oxytocin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release., [UniProtKB, PubMed]; Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes., [RefSeq, PubMed]; Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats. Publication Status: Online-Only, [RefSeq, PubMed]; Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin., [RefSeq, PubMed]; Neurobiological mechanisms underlying oxytocin-mediated parental behavior in rodents. Review article, [RefSeq, PubMed]; Neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:17170309, PubMed:17925443, PubMed:21719680). Released in response to a variety of social cues and acts by binding to oxytocin receptor (OXTR), triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:17170309, PubMed:21719680). Central release (direct secretion in the brain) plays essential roles in social behavior, such as maternal care, male mating behavior, social cognition and affiliative behaviors (PubMed:17170309, PubMed:21719680). Stressful and anxiogenic stimuli promote release of oxytocin, which acts as a powerful modulator of anxiety- and stress-related behaviors (PubMed:21719680). Modulates neural circuits related to reward, fear and social approach, encouraging care and cooperation, but can also increase guilt or aggression towards out-groups (By similarity). Beyond its role in social behavior, plays a role in other processes, such as parturition, lactation or osteoblast differentiation, when released peripherally (secreted from the posterior pituitary gland into the bloodstream) (By similarity). Required for parturition and milk ejection by triggering and strengthening contraction of the smooth muscle of the uterus and mammary gland, respectively (By similarity). Promotes bone mass by stimulating bone formation by osteoblasts (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Precursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53WU2", "ec_number_list": [], "go_molecular_function": "GO:0005185 neurohypophyseal hormone activity;GO:0031855 oxytocin receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0060179 male mating behavior;GO:0060406 positive regulation of penile erection;GO:0010701 positive regulation of norepinephrine secretion;GO:0002125 maternal aggressive behavior;GO:0060450 positive regulation of hindgut contraction", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P01179-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01322-1", "uniprot_id": [ { "id": "INS1_RAT", "url": "https://www.uniprot.org/uniprot/P01322", "type": "external" } ], "mass": 12421.0, "length": 110, "protein_name": "Insulin-1", "gene_name": "Ins1", "organism": "Rat", "refseq_name": "insulin-1 preproprotein", "refseq_ac": [ { "id": "NP_062002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062002", "type": "external" } ], "gene_names_uniprotkb": "Ins1; Ins-1", "gene_names_refseq": "Ins1", "protein_names_uniprotkb": "Insulin-1", "protein_names_refseq": "insulin-1 preproprotein", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24505); (R-RNO-264876); (R-RNO-422085); (R-RNO-6807878); (R-RNO-6811558); (R-RNO-74713); (R-RNO-74749); (R-RNO-74751); (R-RNO-74752); (R-RNO-77387)", "pathway_count": 10, "publication_count": 11, "publication_id_list": "30879761;31257494;32325912;32631952;35562179;4311938;4554104;4640931;498283;498284;6249167", "class_list": "", "function": "Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats., [RefSeq, PubMed]; Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]; NPB and NPBW1 mRNA was expressed in INS1E cells and rat pancreatic islets. In INS1E cells, NPB enhanced insulin 1 mRNA expression via an ERK1/2dependent mechanism, [RefSeq, PubMed]; RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggest that CPG16 plays a role in the suppression of insulin gene expression in pancreatic beta-cells under glucotoxic conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0050714 positive regulation of protein secretion;GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01322-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01323-1", "uniprot_id": [ { "id": "INS2_RAT", "url": "https://www.uniprot.org/uniprot/P01323", "type": "external" } ], "mass": 12339.0, "length": 110, "protein_name": "Insulin-2", "gene_name": "Ins2", "organism": "Rat", "refseq_name": "insulin-2 preproprotein", "refseq_ac": [ { "id": "NP_062003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062003", "type": "external" } ], "gene_names_uniprotkb": "Ins2; Ins-2", "gene_names_refseq": "CP-II; Ins2", "protein_names_uniprotkb": "Insulin-2", "protein_names_refseq": "C-peptide; insulin-2 preproprotein", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); permanent neonatal diabetes mellitus (Disease Ontology:DOID:0060639); amelogenesis imperfecta type 4 (Disease Ontology:DOID:0110053); type 1 diabetes mellitus 2 (Disease Ontology:DOID:0110741); maturity-onset diabetes of the young type 10 (Disease Ontology:DOID:0111108); trichodontoosseous syndrome (Disease Ontology:DOID:0111565); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); neonatal diabetes mellitus (Disease Ontology:DOID:11717); pancreatic cancer (Disease Ontology:DOID:1793); hyperuricemia (Disease Ontology:DOID:1920); hyperinsulinism (Disease Ontology:DOID:2018); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); insulinoma (Disease Ontology:DOID:3892); cholangiocarcinoma (Disease Ontology:DOID:4947); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24506); (R-RNO-264876); (R-RNO-422085); (R-RNO-6807878); (R-RNO-6811558); (R-RNO-74713); (R-RNO-74749); (R-RNO-74751); (R-RNO-74752); (R-RNO-77387)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "2427930;28410130;30790128;32631952;35562179;4311938;4554104;4640931;498284;6249167", "class_list": "", "function": "Deletion of the insulin promoter region revealed that nucleotide positions - 238 to - 144 (relative to the transcriptional start site) were needed for ER repression of the rat insulin II gene., [RefSeq, PubMed]; Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats., [RefSeq, PubMed]; Expression of ghrelin and ghrelin receptor and glucose stimulated insulin secretion (GSIS) of pancreatic islets. Publication Status: Online-Only, [RefSeq, PubMed]; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver., [UniProtKB]; RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005158 insulin receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030141 secretory granule", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0050709 negative regulation of protein secretion;GO:0045818 negative regulation of glycogen catabolic process;GO:0045922 negative regulation of fatty acid metabolic process;GO:0046631 alpha-beta T cell activation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P01323-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01581-1", "uniprot_id": [ { "id": "IFNG_RAT", "url": "https://www.uniprot.org/uniprot/P01581", "type": "external" } ], "mass": 17918.0, "length": 156, "protein_name": "Interferon gamma", "gene_name": "Ifng", "organism": "Rat", "refseq_name": "interferon gamma precursor", "refseq_ac": [ { "id": "NP_620235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620235", "type": "external" } ], "gene_names_uniprotkb": "Ifng", "gene_names_refseq": "IFNG2; If2f; Ifng", "protein_names_uniprotkb": "Interferon gamma; IFN-gamma", "protein_names_refseq": "IFN-gamma; interferon 2f; interferon gamma precursor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); lupus nephritis (Disease Ontology:DOID:0080162); tuberous sclerosis 2 (Disease Ontology:DOID:0080325); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); immunodeficiency 69 (Disease Ontology:DOID:0112006); sensorineural hearing loss (Disease Ontology:DOID:10003); dermatomyositis (Disease Ontology:DOID:10223); celiac disease (Disease Ontology:DOID:10608); otitis media (Disease Ontology:DOID:10754); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); brucellosis (Disease Ontology:DOID:11077); pulpitis (Disease Ontology:DOID:11121); allergic conjunctivitis (Disease Ontology:DOID:11204); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); suppurative otitis media (Disease Ontology:DOID:11506); panuveitis (Disease Ontology:DOID:12030); factor VIII deficiency (Disease Ontology:DOID:12134); Chagas disease (Disease Ontology:DOID:12140); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); aplastic anemia (Disease Ontology:DOID:12449); ataxia telangiectasia (Disease Ontology:DOID:12704); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); Fanconi anemia (Disease Ontology:DOID:13636); toxic shock syndrome (Disease Ontology:DOID:14115); selective IgG deficiency disease (Disease Ontology:DOID:14176); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); hepatitis (Disease Ontology:DOID:2237); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); high grade glioma (Disease Ontology:DOID:3070); chronic granulomatous disease (Disease Ontology:DOID:3265); atopic dermatitis (Disease Ontology:DOID:3310); mixed connective tissue disease (Disease Ontology:DOID:3492); acute retinal necrosis syndrome (Disease Ontology:DOID:3611); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); endophthalmitis (Disease Ontology:DOID:4692); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); abdominal aortic aneurysm (Disease Ontology:DOID:7693); lung disease (Disease Ontology:DOID:850); myeloid leukemia (Disease Ontology:DOID:8692); Crohn's disease (Disease Ontology:DOID:8778); leishmaniasis (Disease Ontology:DOID:9065); systemic lupus erythematosus (Disease Ontology:DOID:9074); eczema herpeticum (Disease Ontology:DOID:9123); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); vesicoureteral reflux (Disease Ontology:DOID:9620); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25712); (R-RNO-877300); (R-RNO-877312); (R-RNO-9732724)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "3093809;32448218;37260264;3924594", "class_list": "", "function": "IFN-gamma deficiency in the rostral ventrolateral medulla contributes to stress-induced hypertension by impairing microglial synaptic engulfment., [RefSeq, PubMed]; Transgenerational inheritance of fetal alcohol exposure adverse effects on immune gene interferon-Upsilon. Publication Status: Online-Only, [RefSeq, PubMed]; Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 84, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043204 perikaryon;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0071351 cellular response to interleukin-18", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P01581-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01805-1", "uniprot_id": [ { "id": "HVR01_RAT", "url": "https://www.uniprot.org/uniprot/P01805", "type": "external" } ], "mass": 16024.0, "length": 142, "protein_name": "Ig heavy chain V region IR2", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig heavy chain V region IR2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6292865", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0019814 immunoglobulin complex", "go_biological_process": "GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01805-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01855-1", "uniprot_id": [ { "id": "IGHE_RAT", "url": "https://www.uniprot.org/uniprot/P01855", "type": "external" } ], "mass": 48671.0, "length": 429, "protein_name": "Immunoglobulin heavy constant epsilon", "gene_name": "IGHE", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IGHE", "gene_names_refseq": "", "protein_names_uniprotkb": "Immunoglobulin heavy constant epsilon; Ig epsilon chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "agammaglobulinemia 1 (Disease Ontology:DOID:0081136); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); allergic rhinitis (Disease Ontology:DOID:4481); pulmonary eosinophilia (Disease Ontology:DOID:9498); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2443834;6292865;6803238;6820340", "class_list": "", "function": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0042613 MHC class II protein complex", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0043306 positive regulation of mast cell degranulation;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0050853 B cell receptor signaling pathway;GO:0050870 positive regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P01855-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01883-1", "uniprot_id": [ { "id": "IGHD_RAT", "url": "https://www.uniprot.org/uniprot/P01883", "type": "external" } ], "mass": 22423.0, "length": 202, "protein_name": "Ig delta chain C region", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig delta chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6819978", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01883-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04073-1", "uniprot_id": [ { "id": "PEPC_RAT", "url": "https://www.uniprot.org/uniprot/P04073", "type": "external" } ], "mass": 42833.0, "length": 392, "protein_name": "Gastricsin", "gene_name": "Pgc", "organism": "Rat", "refseq_name": "gastricsin precursor", "refseq_ac": [ { "id": "NP_579818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579818", "type": "external" } ], "gene_names_uniprotkb": "Pgc", "gene_names_refseq": "PG1; Pg-1; Pgc; Upg1", "protein_names_uniprotkb": "Gastricsin; 3.4.23.3; Pepsinogen C", "protein_names_refseq": "Urinary pepsinogen 1; gastricsin precursor; gastricsin; progastricsin (pepsinogen C)", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:24864)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2722863;3780741;6743670", "class_list": "", "function": "Hydrolyzes a variety of proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion;GO:0002803 positive regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P04073-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04785-1", "uniprot_id": [ { "id": "PDIA1_RAT", "url": "https://www.uniprot.org/uniprot/P04785", "type": "external" } ], "mass": 56951.0, "length": 509, "protein_name": "Protein disulfide-isomerase", "gene_name": "P4hb", "organism": "Rat", "refseq_name": "protein disulfide-isomerase precursor", "refseq_ac": [ { "id": "NP_037130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037130", "type": "external" } ], "gene_names_uniprotkb": "P4hb; Pdia1", "gene_names_refseq": "P4hb; PDIR; PDI", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1; Cellular thyroid hormone-binding protein; PDI; Prolyl 4-hydroxylase subunit beta", "protein_names_refseq": "Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); cellular thyroid hormone-binding protein; prolyl 4-hydroxylase, beta polypeptide; protein disulfide-isomerase precursor; protein disulfide-isomerase", "tax_id": 10116, "disease": "Cole-Carpenter syndrome (Disease Ontology:DOID:0060438)", "pathway": " (rno:25506); (R-RNO-1650814); (R-RNO-264876); (R-RNO-3299685); (R-RNO-381426); (R-RNO-5358346); (R-RNO-8866423); (R-RNO-8957275); (R-RNO-8963888); (R-RNO-8964041); (R-RNO-9020591); (R-RNO-9020933)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "18047804;21454685;24333444;2757644;28198441;2841089;3178809;34502162;3840230;8251535;8366073", "class_list": "", "function": "As the XBP-1/PDI/MTP axis has been suggested to represent a significant lipogenic mechanism in the liver response to ER stress, our data indicate that hypertriglyceridemia and liver steatosis occurring MSG rats are associated with increased MTP., [RefSeq, PubMed]; PDI knockdown inhibited the reduction of disulfide bonds on NMDAR subunits, resulting in decreased seizure susceptibility in response to PILO. Publication Status: Online-Only, [RefSeq, PubMed]; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13700", "ec_number_list": [ { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:2000406 positive regulation of T cell migration;GO:0071456 cellular response to hypoxia;GO:0046598 positive regulation of viral entry into host cell;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P04785-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04897-1", "uniprot_id": [ { "id": "GNAI2_RAT", "url": "https://www.uniprot.org/uniprot/P04897", "type": "external" } ], "mass": 40499.0, "length": 355, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-2", "gene_name": "Gnai2", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-2", "refseq_ac": [ { "id": "NP_112297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112297", "type": "external" } ], "gene_names_uniprotkb": "Gnai2; Gnai-2", "gene_names_refseq": "Galphai2; Gnai2; Hg1c", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-2; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); GTP-binding protein (G-alpha-i2); adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; heterotrimeric guanine nucleotide-binding protein 1c", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); inflammatory bowel disease 12 (Disease Ontology:DOID:0110887); hypertension (Disease Ontology:DOID:10763); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:81664); (R-RNO-170670); (R-RNO-392170); (R-RNO-400042); (R-RNO-418594); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "11121039;11387333;15337739;16870394;17635935;19211784;2159473;21653697;2820999;28692698;3086867;38843836", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. Examples of interacting GPCRs include the adenosine A1 receptor/ADORA1, CNR1, and FPR2. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels. Plays an important role in the activation of the transcription factor NFAT in endothelial cells to promote angiogenesis. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. Plays an essential role for neutrophil recruitment in the context of acute inflammation suggesting a linked function of both GNAI2 in neutrophils and endothelial cells for polymorphonuclear neutrophils transmigration., [UniProtKB, UniProtKB, UniProtKB]; Nitric oxide decreased the enhanced expression of Gialpha-2/3 proteins and hyperproliferation of Vascular smooth muscle cells from spontaneously hypertensive rats by cGMP-independent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P04897-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05011-1", "uniprot_id": [ { "id": "IFNA1_RAT", "url": "https://www.uniprot.org/uniprot/P05011", "type": "external" } ], "mass": 21935.0, "length": 192, "protein_name": "Interferon alpha-1", "gene_name": "Ifna1", "organism": "Rat", "refseq_name": "interferon alpha-1 precursor", "refseq_ac": [ { "id": "NP_001014786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014786", "type": "external" } ], "gene_names_uniprotkb": "Ifna1", "gene_names_refseq": "IFN-alpha1; Ifna1l1; Ifna1; Ifna5", "protein_names_uniprotkb": "Interferon alpha-1", "protein_names_refseq": "interferon alpha-1 precursor; interferon-alpha 1-like 1; interferon-alpha 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298210); (R-RNO-909733); (R-RNO-912694)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20214528;3020354;6320120", "class_list": "", "function": "IFN-gamma is able to activate rat intestinal mucous microvascular endothelial cells, thereby leading to upregulated expressions of IFN-alpha/beta., [RefSeq, PubMed]; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05011-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05982-1", "uniprot_id": [ { "id": "NQO1_RAT", "url": "https://www.uniprot.org/uniprot/P05982", "type": "external" } ], "mass": 30947.0, "length": 274, "protein_name": "NAD(P)H dehydrogenase [quinone] 1", "gene_name": "Nqo1", "organism": "Rat", "refseq_name": "NAD(P)H dehydrogenase [quinone] 1", "refseq_ac": [ { "id": "NP_058696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058696", "type": "external" } ], "gene_names_uniprotkb": "Nqo1; Nmor1", "gene_names_refseq": "Dia4; Nqo1", "protein_names_uniprotkb": "NAD(P)H dehydrogenase [quinone] 1; 1.6.5.2; Azoreductase; DT-diaphorase; DTD; Menadione reductase; NAD(P)H:quinone oxidoreductase 1; Phylloquinone reductase; QR1; Quinone reductase 1", "protein_names_refseq": "DT-diaphorase; DTD; Diaphorase (NADH/NADPH); NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H:menadione oxidoreductase; NAD(P)H:quinone oxidoreductase 1; QR1; azoreductase; menadione reductase; phylloquinone reductase; quinone reductase 1", "tax_id": 10116, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); alcoholic hepatitis (Disease Ontology:DOID:12351); leukemia (Disease Ontology:DOID:1240); neurodegenerative disease (Disease Ontology:DOID:1289); cholestasis (Disease Ontology:DOID:13580); prostatitis (Disease Ontology:DOID:14654); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); urinary system cancer (Disease Ontology:DOID:3996); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); chronic kidney disease (Disease Ontology:DOID:784); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); liver benign neoplasm (Disease Ontology:DOID:916); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24314); (R-RNO-350562)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "1703398;2141979;2480957;2499768;2504488;2963593;3100515;3143406;3144286;32685505;34817874;3536915;37002649;37285672;7568029;7862630;8999809", "class_list": "", "function": "A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation., [RefSeq, PubMed]; Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (PubMed:1703398, PubMed:7862630, PubMed:8999809). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1., [RefSeq, PubMed]; NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells., [RefSeq, PubMed]; Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63478", "ec_number_list": [ { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.2", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003955 NAD(P)H dehydrogenase (quinone) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0004784 superoxide dismutase activity;GO:0050136 NADH dehydrogenase (quinone) (non-electrogenic) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0043279 response to alkaloid;GO:1905395 response to flavonoid;GO:1904880 response to hydrogen sulfide;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P05982-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06303-1", "uniprot_id": [ { "id": "PAHO_RAT", "url": "https://www.uniprot.org/uniprot/P06303", "type": "external" } ], "mass": 10975.0, "length": 98, "protein_name": "Pancreatic polypeptide prohormone", "gene_name": "Ppy", "organism": "Rat", "refseq_name": "pancreatic polypeptide prohormone precursor", "refseq_ac": [ { "id": "NP_036758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036758", "type": "external" } ], "gene_names_uniprotkb": "Ppy", "gene_names_refseq": "Ppy", "protein_names_uniprotkb": "Pancreatic polypeptide prohormone", "protein_names_refseq": "PP; pancreatic polypeptide prohormone precursor; pancreatic polypeptide prohormone; pancreatic prohormone", "tax_id": 10116, "disease": "", "pathway": " (rno:24677); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15817809;3009446;3214179;3343236", "class_list": "", "function": "Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2., [UniProtKB, UniProtKB]; Pancreas-projecting rat dorsal motor nucleus of the vagus neurons are heterogeneous with respect to their response to PP, which may underlie functional differences in the vagal modulation of pancreatic functions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P06303-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07323-1", "uniprot_id": [ { "id": "ENOG_RAT", "url": "https://www.uniprot.org/uniprot/P07323", "type": "external" } ], "mass": 47141.0, "length": 434, "protein_name": "Gamma-enolase", "gene_name": "Eno2", "organism": "Rat", "refseq_name": "gamma-enolase", "refseq_ac": [ { "id": "NP_647541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647541", "type": "external" } ], "gene_names_uniprotkb": "Eno2; Eno-2", "gene_names_refseq": "Eno2; NSE; RNEN3", "protein_names_uniprotkb": "Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 2; NSE; Neural enolase; Neuron-specific enolase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; enolase 2, gamma, neuronal; gamma-enolase-like; gamma-enolase; neural enolase; neuron-specific enolase", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); migraine without aura (Disease Ontology:DOID:12783); toxic shock syndrome (Disease Ontology:DOID:14115); neuroendocrine carcinoma (Disease Ontology:DOID:1800); breast carcinoma (Disease Ontology:DOID:3459); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:24334); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "15041191;18683930;22673903;24042457;2450052;27291422;28508170;2865729;29728894;3746946;7753500", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (PubMed:7753500)., [UniProtKB, UniProtKB, PubMed]; Gamma-enolase may signal and correlate lung tissue damage well before obvious physical pathological tissue damage and might be a candidate diagnostic and/or prognostic marker., [RefSeq, PubMed]; Hyperglycemia may impair mitochondrial function and alter glycolysis in glomerular epithelial cells by down-regulating the expression of ATP synthase beta subunit and enolase 2., [RefSeq, PubMed]; Study analyzed the regions that regulate the promoter strength and cellular specificity of the 1.8 kb rNSE promoter in the cerebellum in vivo. The rNSE promoter was divided into three regions (A, B, and C). Our results showed that region C was indispensable for the promoter activity in mouse cerebellum and served as an interneuron-predominant basal promoter., [RefSeq, PubMed]; Study showed that the NSE promoter was activated in astrocytes, including Bergmann glia (BG), but not Purkinje cells (PCs), in the traumatic region of the cerebellar cortex. This PC to BG switch was associated with local microglial invasion. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0032355 response to estradiol;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07323-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07633-1", "uniprot_id": [ { "id": "PCCB_RAT", "url": "https://www.uniprot.org/uniprot/P07633", "type": "external" } ], "mass": 58626.0, "length": 541, "protein_name": "Propionyl-CoA carboxylase beta chain, mitochondrial", "gene_name": "Pccb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pccb", "gene_names_refseq": "", "protein_names_uniprotkb": "Propionyl-CoA carboxylase beta chain, mitochondrial; 6.4.1.3; PCCase subunit beta; Propanoyl-CoA:carbon dioxide ligase subunit beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); leukodystrophy (Disease Ontology:DOID:10579); Alzheimer's disease (Disease Ontology:DOID:10652); propionic acidemia (Disease Ontology:DOID:14701); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (R-RNO-196780); (R-RNO-71032); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3464942", "class_list": "", "function": "This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004658 propionyl-CoA carboxylase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1902494 catalytic complex", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0009063 amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P07633-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07647-1", "uniprot_id": [ { "id": "KLK9_RAT", "url": "https://www.uniprot.org/uniprot/P07647", "type": "external" } ], "mass": 28368.0, "length": 259, "protein_name": "Submandibular glandular kallikrein-9", "gene_name": "Klk1c4; Klk1c9; Klk9", "organism": "Rat", "refseq_name": "submandibular glandular kallikrein-9 precursor", "refseq_ac": [ { "id": "NP_786935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786935", "type": "external" } ], "gene_names_uniprotkb": "Klk1c4; Klk1c9; Klk9; Klk-9; Klk1c9; Klks3", "gene_names_refseq": "Klk1c9; Klk9; Klks3; Klna2; rGK-9; rK9", "protein_names_uniprotkb": "Submandibular glandular kallikrein-9; 3.4.21.35; KLK-S3; S3 kallikrein; SEV; Submandibular enzymatic vasoconstrictor; Tissue kallikrein; rGK-9", "protein_names_refseq": "KLK-S3; S3 kallikrein; SEV; kallikrein a2; kallikrein, submaxillary gland S3; submandibular enzymatic vasoconstrictor; submandibular glandular kallikrein-9 precursor; submandibular glandular kallikrein-9; submaxillary gland S3 kallikrein; tissue kallikrein", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:292868)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1315752;1536657;17366701;1900513;2998455", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This enzyme has a vasoconstrictor activity. KLK-9 has both a chymotrypsin-like and a trypsin-like properties., [UniProtKB]; Klks3 rat gene was expressed at high levels in the submandibular glands of transgenic mice., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0045907 positive regulation of vasoconstriction;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07647-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07936-1", "uniprot_id": [ { "id": "NEUM_RAT", "url": "https://www.uniprot.org/uniprot/P07936", "type": "external" } ], "mass": 23603.0, "length": 226, "protein_name": "Neuromodulin", "gene_name": "Gap43", "organism": "Rat", "refseq_name": "neuromodulin", "refseq_ac": [ { "id": "NP_058891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058891", "type": "external" } ], "gene_names_uniprotkb": "Gap43", "gene_names_refseq": "Basp2; Gap43", "protein_names_uniprotkb": "Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Protein F1", "protein_names_refseq": "axonal membrane protein GAP-43; brain abundant, membrane attached signal protein 2; growth accentuating protein 43; neuromodulin; protein F1", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:29423); (R-RNO-373760)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10982410;11948657;12106089;12957493;1533624;17577668;18375950;21890113;22673903;23793170;2437653;33953268;3428269;34643252;35715368;3581170;38168094;38288820;8454596;9183817", "class_list": "", "function": "NEP140 promotes myelin regeneration via upregulation of GAP43 and MAP2 expression after focal cerebral ischemia in rats. Erratum:[Mol Med Rep. 2023 Mar;27(3):58. doi: 10.3892/mmr.2023.12945. PMID: 36695184], [RefSeq, PubMed]; P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats., [RefSeq, PubMed]; Paternal stress alters synaptic density and expression of GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring of stress-induced male rats., [RefSeq, PubMed]; The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity)., [UniProtKB, UniProtKB]; Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPM4", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0001786 phosphatidylserine binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016198 axon choice point recognition;GO:0007399 nervous system development;GO:0040008 regulation of growth;GO:0010996 response to auditory stimulus;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P07936-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08568-1", "uniprot_id": [ { "id": "GRPA_RAT", "url": "https://www.uniprot.org/uniprot/P08568", "type": "external" } ], "mass": 26528.0, "length": 246, "protein_name": "Submandibular gland secretory Glx-rich protein CA", "gene_name": "Grpca", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Grpca", "gene_names_refseq": "", "protein_names_uniprotkb": "Submandibular gland secretory Glx-rich protein CA; GRP-CA", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1995617;2438276", "class_list": "", "function": "GRP proteins have a marked affinity for hydroxyapatite. They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046848 hydroxyapatite binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08568-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09634-1", "uniprot_id": [ { "id": "HXA7_RAT", "url": "https://www.uniprot.org/uniprot/P09634", "type": "external" } ], "mass": 12552.0, "length": 105, "protein_name": "Homeobox protein Hox-A7", "gene_name": "Hoxa7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxa7; Hoxa-7", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A7; Homeobox protein Hox-1.1; Homeobox protein R5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:500126)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2886401", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09634-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09655-1", "uniprot_id": [ { "id": "ISK1_RAT", "url": "https://www.uniprot.org/uniprot/P09655", "type": "external" } ], "mass": 8528.0, "length": 79, "protein_name": "Serine protease inhibitor Kazal-type 1", "gene_name": "Spink1", "organism": "Rat", "refseq_name": "serine protease inhibitor Kazal-type 1 precursor", "refseq_ac": [ { "id": "NP_036806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036806", "type": "external" } ], "gene_names_uniprotkb": "Spink1", "gene_names_refseq": "PSTI-61; Psti-1; Spink1; Spink3; Tilp", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 1; Cholecystokinin-releasing peptide; Monitor peptide; PSTI-I; Pancreatic secretory trypsin inhibitor", "protein_names_refseq": "PSTI-I; Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic; cholecystokinin-releasing peptide; monitor peptide; pancreatic cholecystokinin(CCK) releasing peptide; pancreatic secretory trypsin inhibitor I; pancreatic secretory trypsin inhibitor-61; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 1 precursor; serine protease inhibitor Kazal-type 1; trypsin inhibitor-like protein, pancreatic", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); thrombocytopenia (Disease Ontology:DOID:1588); ovary epithelial cancer (Disease Ontology:DOID:2152); blood platelet disease (Disease Ontology:DOID:2218); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); cervical adenocarcinoma (Disease Ontology:DOID:3702); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:24833)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1390891;2065678;2293709;2602119;27414783;2751646;3202973;3597401", "class_list": "", "function": "In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (By similarity)., [UniProtKB, UniProtKB]; SPINK3 along with Ccna2 and EGFR accelerated cell proliferation during rat liver regeneration via P38 MAPK, PKC, JAK-STAT and AKT pathways., [RefSeq, PubMed]; Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:3202973, PubMed:3597401). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13072", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:0010466 negative regulation of peptidase activity;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045471 response to ethanol;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P09655-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0P7-1", "uniprot_id": [ { "id": "NPS_RAT", "url": "https://www.uniprot.org/uniprot/P0C0P7", "type": "external" } ], "mass": 9763.0, "length": 89, "protein_name": "Neuropeptide S", "gene_name": "Nps", "organism": "Rat", "refseq_name": "neuropeptide S precursor", "refseq_ac": [ { "id": "NP_001258042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258042", "type": "external" } ], "gene_names_uniprotkb": "Nps", "gene_names_refseq": "Nps", "protein_names_uniprotkb": "Neuropeptide S", "protein_names_refseq": "neuropeptide S precursor", "tax_id": 10116, "disease": "morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (rno:100360071); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15312648;15919054;17645946;18564106;21861171;29157796;32044336;32441169;36195130;37832875", "class_list": "", "function": "(1) NPS efficiently prevents development of and reverses the posttraumatic stress symptomatology caused by exposure to stress; (2) the mechanisms of action involve both the NPS receptor and NPY-Y1R; and (3) NPS may affect the NPY-Y1R, indicating a possible cross talk between the NPYergic system and NPS. Treatment with NPS may be a novel approach for the treatment of the deleterious consequences of stress exposure., [RefSeq, PubMed]; Data suggest a role for neuropeptide S in the modulation of ethanol drinking and possibly anxiety-like behavior in rats selectively bred for high alcohol drinking., [RefSeq, PubMed]; Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC., [RefSeq, PubMed]; Ligand for NPSR1 (PubMed:15312648). Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway (PubMed:15312648). This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (By similarity). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (By similarity). May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity., [UniProtKB, PubMed, PubMed, UniProtKB]; Neuropeptide S facilitates extinction of fear via modulation of mesolimbic dopaminergic circuitry., [RefSeq, PubMed]; Nicotine treatment up-regulated neuropeptide s (NPS) and its receptor (NPS-R) in hypothalamus and brainstem., [RefSeq, PubMed]; The effect of chronic neuropeptide-S treatment on non-motor parameters in experimental model of Parkinson's disease., [RefSeq, PubMed]; The regulatory role of central neuropeptide-S in locomotion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008542 visual learning;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0051968 positive regulation of synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0C0P7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0W8-1", "uniprot_id": [ { "id": "GP139_RAT", "url": "https://www.uniprot.org/uniprot/P0C0W8", "type": "external" } ], "mass": 39742.0, "length": 345, "protein_name": "Probable G protein-coupled receptor 139", "gene_name": "Gpr139", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 139", "refseq_ac": [ { "id": "NP_001019412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019412", "type": "external" } ], "gene_names_uniprotkb": "Gpr139; Gprg1", "gene_names_refseq": "Gpr139", "protein_names_uniprotkb": "Probable G protein-coupled receptor 139; G(q)-coupled orphan receptor GPRg1", "protein_names_refseq": "g(q)-coupled orphan receptor GPRg1; probable G-protein coupled receptor 139", "tax_id": 10116, "disease": "", "pathway": " (rno:293545)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15845401;29971251;32531213", "class_list": "", "function": "Orphan receptor. Seems to act through a G(q/11)-mediated pathway., [UniProtKB]; Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models., [RefSeq, PubMed]; These results provide robust preclinical evidence that G protein-coupled receptor 139 (GPR139)activation reverses key addiction-like behaviors in dependent animals, suggest that GPR139 may be a novel target for the treatment of alcohol use disorder, and demonstrate that GPR139 is functionally relevant in regulating mammalian behavior. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C0W8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2N5-1", "uniprot_id": [ { "id": "KMT5B_RAT", "url": "https://www.uniprot.org/uniprot/P0C2N5", "type": "external" } ], "mass": 98668.0, "length": 883, "protein_name": "Histone-lysine N-methyltransferase KMT5B", "gene_name": "Kmt5b", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase KMT5B", "refseq_ac": [ { "id": "NP_001101982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101982", "type": "external" } ], "gene_names_uniprotkb": "Kmt5b; Suv420h1", "gene_names_refseq": "Kmt5b; Suv420h1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5B; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5B; Su(var)4-20 homolog 1; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine (K)-specific methyltransferase 5B; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1; suv4-20h1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 51 (Disease Ontology:DOID:0080232)", "pathway": " (rno:361688); (R-RNO-3214841)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042054 histone methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000779 condensed chromosome, centromeric region;GO:0005694 chromosome", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007517 muscle organ development;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2N5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6P7-1", "uniprot_id": [ { "id": "FEM1B_RAT", "url": "https://www.uniprot.org/uniprot/P0C6P7", "type": "external" } ], "mass": 70237.0, "length": 627, "protein_name": "Protein fem-1 homolog B", "gene_name": "Fem1b", "organism": "Rat", "refseq_name": "protein fem-1 homolog B", "refseq_ac": [ { "id": "NP_001101627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101627", "type": "external" } ], "gene_names_uniprotkb": "Fem1b", "gene_names_refseq": "Fem1b", "protein_names_uniprotkb": "Protein fem-1 homolog B; FEM1-beta; FEM1b", "protein_names_refseq": "FEM1-beta; feminization 1 homolog b; feminization of XX and XO animals 1B; protein fem-1 homolog B", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:315745); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15601915", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (By similarity). Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2(FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity). Mechanistically, recognizes and binds reduced FNIP1 through two interface zinc ions, which act as a molecular glue that recruit reduced FNIP1 to FEM1B (By similarity). Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (By similarity). Promotes ubiquitination and degradation of ANKRD37 (By similarity). Promotes ubiquitination and degradation of SLBP. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity). Also involved in glucose homeostasis in pancreatic islet (By similarity). May also act as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0060743 epithelial cell maturation involved in prostate gland development;GO:2000001 regulation of DNA damage checkpoint;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C6P7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CI71-1", "uniprot_id": [ { "id": "K0319_RAT", "url": "https://www.uniprot.org/uniprot/P0CI71", "type": "external" } ], "mass": 118013.0, "length": 1081, "protein_name": "Dyslexia-associated protein KIAA0319 homolog", "gene_name": "Kiaa0319", "organism": "Rat", "refseq_name": "dyslexia-associated protein KIAA0319 homolog precursor", "refseq_ac": [ { "id": "NP_001183952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001183952", "type": "external" } ], "gene_names_uniprotkb": "Kiaa0319; RGD1307443", "gene_names_refseq": "Kiaa0319; RGD1307443", "protein_names_uniprotkb": "Dyslexia-associated protein KIAA0319 homolog", "protein_names_refseq": "dyslexia susceptibility 2; dyslexia-associated protein KIAA0319 homolog precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:361244); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16600991;19679544;23220223;23395846;24871331;28334068", "class_list": "", "function": "Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites., [UniProtKB, PubMed, PubMed]; Reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia. Publication Status: Online-Only, [RefSeq, PubMed]; Study establishes KIAA0319 as a novel player in axon growth and regeneration with the ability to repress the intrinsic growth potential of axons; describes a novel regulatory mechanism operating during peripheral nervous system and central nervous system axon growth, and offers novel targets for the development of effective therapies to promote axon regeneration, [RefSeq, PubMed]; These results provide the first evidence that decreased expression of the dyslexia-associated gene Kiaa0319 can alter cortical responses and impair phoneme processing in auditory cortex., [RefSeq, PubMed]; These results suggest that Kiaa0319 has a specific involvement in neural systems important for temporal processing., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0031901 early endosome membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0010996 response to auditory stimulus;GO:2000171 negative regulation of dendrite development;GO:0060391 positive regulation of SMAD protein signal transduction;GO:0030517 negative regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P0CI71-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DMW0-1", "uniprot_id": [ { "id": "HS71A_RAT", "url": "https://www.uniprot.org/uniprot/P0DMW0", "type": "external" } ], "mass": 70185.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1A", "gene_name": "Hspa1a; Hspa1b", "organism": "Rat", "refseq_name": "heat shock 70 kDa protein 1A", "refseq_ac": [ { "id": "NP_114177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114177", "type": "external" } ], "gene_names_uniprotkb": "Hspa1a; Hspa1b; Hsp70-1; Hsp70-2; Hspa1a; Hspa1b; Hspa1; Hspa2", "gene_names_refseq": "HSP70-2; HSP70.1; HSP70.2; HSP72; Hsp70-1; Hspa1a; Hspa1", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1A; HSP70-2; HSP70.2; Heat shock 70 kDa protein 2", "protein_names_refseq": "HSP70-1/HSP70-2; HSP70.1/2; HSP70.1/HSP70.2; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1B; heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock protein 70-1", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:108348108); (rno:24472); (R-RNO-3371453); (R-RNO-3371497); (R-RNO-3371568); (R-RNO-3371571); (R-RNO-450408); (R-RNO-6798695); (R-RNO-9833482); (R-RNO-9841251)", "pathway_count": 10, "publication_count": 15, "publication_id_list": "12397027;15060004;19237536;29934347;30980393;32199935;33546324;33573715;34502162;35457282;36538982;7927536;8086479;8141767;8271311", "class_list": "", "function": "Chaperone Hsp70 (HSPA1) Is Involved in the Molecular Mechanisms of Sleep Cycle Integration. Publication Status: Online-Only, [RefSeq, PubMed]; Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress. Publication Status: Online-Only, [RefSeq, PubMed]; HSPA1A ameliorated spinal cord injury in rats by inhibiting apoptosis to exert neuroprotective effects. Erratum:[Exp Neurol. 2023 Jul;365:114419. doi: 10.1016/j.expneurol.2023.114419. PMID: 37127509], [RefSeq, PubMed]; Inducible heat shock protein A1A (HSPA1A) is markedly expressed in rat myometrium by labour and secreted via myometrial cell-derived extracellular vesicles., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P42853;Q07439;Q63256", "ec_number_list": [], "go_molecular_function": "GO:0031249 denatured protein binding;GO:0055131 C3HC4-type RING finger domain binding;GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0033120 positive regulation of RNA splicing;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P0DMW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DN35-1", "uniprot_id": [ { "id": "NDUB1_RAT", "url": "https://www.uniprot.org/uniprot/P0DN35", "type": "external" } ], "mass": 6998.0, "length": 57, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "gene_name": "Ndufb1", "organism": "Rat", "refseq_name": "nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "refseq_ac": [ { "id": "NP_001389475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389475", "type": "external" } ], "gene_names_uniprotkb": "Ndufb1", "gene_names_refseq": "CI-MNLL; Ndufb1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; CI-MNLL; Complex I-MNLL; NADH-ubiquinone oxidoreductase MNLL subunit", "protein_names_refseq": "Complex I-MNLL; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1; NADH-ubiquinone oxidoreductase MNLL subunit; nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:100912357); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0DN35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DO93-1", "uniprot_id": [ { "id": "ENOL_RAT", "url": "https://www.uniprot.org/uniprot/P0DO93", "type": "external" } ], "mass": 9833.0, "length": 89, "protein_name": "Putative protein T-ENOL", "gene_name": "Cdiptos; T-enol", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdiptos; T-enol; LOC102552638", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative protein T-ENOL; Testicular enolase domain-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:102552638)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25210130", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0DO93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10118-1", "uniprot_id": [ { "id": "HSP1_RAT", "url": "https://www.uniprot.org/uniprot/P10118", "type": "external" } ], "mass": 7020.0, "length": 51, "protein_name": "Sperm protamine P1", "gene_name": "Prm1", "organism": "Rat", "refseq_name": "sperm protamine P1", "refseq_ac": [ { "id": "NP_001002850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002850", "type": "external" } ], "gene_names_uniprotkb": "Prm1; Prm-1", "gene_names_refseq": "Prm1", "protein_names_uniprotkb": "Sperm protamine P1; Cysteine-rich protamine", "protein_names_refseq": "cysteine-rich protamine; protamine P1; sperm protamine P1", "tax_id": 10116, "disease": "", "pathway": " (rno:24685)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1268226;2757789;3072011;8720108", "class_list": "", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN03", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000786 nucleosome", "go_biological_process": "GO:0007286 spermatid development;GO:0030261 chromosome condensation;GO:0006997 nucleus organization;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10118-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10247-1", "uniprot_id": [ { "id": "HG2A_RAT", "url": "https://www.uniprot.org/uniprot/P10247", "type": "external" } ], "mass": 31642.0, "length": 280, "protein_name": "H-2 class II histocompatibility antigen gamma chain", "gene_name": "Cd74", "organism": "Rat", "refseq_name": "H-2 class II histocompatibility antigen gamma chain", "refseq_ac": [ { "id": "NP_037201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037201", "type": "external" } ], "gene_names_uniprotkb": "Cd74", "gene_names_refseq": "Cd74; INVG34", "protein_names_uniprotkb": "H-2 class II histocompatibility antigen gamma chain; Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain", "protein_names_refseq": "Cd74 molecule, major histocompatibility complex, class II invariant chain; H-2 class II histocompatibility antigen gamma chain; MHC class II-associated invariant chain; ia antigen-associated invariant chain; ii", "tax_id": 10116, "disease": "", "pathway": " (rno:25599); (R-RNO-202733); (R-RNO-2132295)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "22673903;24974304;2499873;27926507;31197516;3264906", "class_list": "", "function": "Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome., [UniProtKB, UniProtKB]; Cytokine MIF was able to elicit inflammatory response of astrocytes through interaction with CD74 receptor, and activation of ERK was necessary for the intracellular signal transduction., [RefSeq, PubMed]; Macrophage migration inhibitory factor (MIF) was identified as a core regulator of inflammatory response following sciatic nerve injury through interaction with CD74 membrane receptor., [RefSeq, PubMed]; Methylglyoxal induced gene expression of CD74 in the in the diabetic retina., [RefSeq, PubMed]; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44., [UniProtKB, UniProtKB]; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035718 macrophage migration inhibitory factor binding;GO:0001540 amyloid-beta binding;GO:0023026 MHC class II protein complex binding;GO:0042609 CD4 receptor binding;GO:0050998 nitric-oxide synthase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0006886 intracellular protein transport;GO:0006952 defense response;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10247-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11598-1", "uniprot_id": [ { "id": "PDIA3_RAT", "url": "https://www.uniprot.org/uniprot/P11598", "type": "external" } ], "mass": 56623.0, "length": 505, "protein_name": "Protein disulfide-isomerase A3", "gene_name": "Ell3; Pdia3", "organism": "Rat", "refseq_name": "protein disulfide-isomerase A3 precursor", "refseq_ac": [ { "id": "NP_059015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059015", "type": "external" } ], "gene_names_uniprotkb": "Ell3; Pdia3; Erp60; Grp58; Pdia3", "gene_names_refseq": "ER60; ERp57; Grp58; Pdia3", "protein_names_uniprotkb": "Protein disulfide-isomerase A3; 5.3.4.1; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; ER protein 57; ER protein 60; ERp57; ERp60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; HIP-70; Q-2; p58", "protein_names_refseq": "58 kDa glucose-regulated protein; 58 kDa microsomal protein; ER protein 57; ER protein 60; ER-60 protease; ERp60; HIP-70; Q-2; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; glucose regulated protein, 58 kDa; oxidoreductase ERp57; p58; protein disulfide isomerase associated 3; protein disulfide-isomerase A3 precursor; protein disulfide-isomerase A3", "tax_id": 10116, "disease": "asphyxia neonatorum (Disease Ontology:DOID:11088); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:29468); (R-RNO-1236974); (R-RNO-901042); (R-RNO-983170)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "12872233;1321829;1330685;15240697;1650195;1657921;18683930;20400973;2181662;24769234;28707894;29104478;31176989;3398923;34338991;9399589", "class_list": "", "function": "Protein disulfide isomerase A3 might be involved in the regulation of 24-dehydrocholesterol reductase via vitamin D equilibrium in primary cortical neurons., [RefSeq, PubMed]; Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteomic data revealed significant Pdia-3 expression in microenvironments of osteoarthritis (OA) joint tissue that could be actively responded to extracorporeal shockwave therapy, which may potentially regulate the biological functions of chondrocytes and osteoblasts in the treatment of the early OA of the knee. Publication Status: Online-Only, [RefSeq, PubMed]; Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats., [RefSeq, PubMed]; VDR and PDIA3/1,25MARRS genes were silenced separately or simultaneously in E16 primary rat cortical neurons, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "7.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0042802 identical protein binding;GO:0008233 peptidase activity;GO:0015035 protein-disulfide reductase activity;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:1903334 positive regulation of protein folding;GO:0002931 response to ischemia;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0031667 response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P11598-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11654-1", "uniprot_id": [ { "id": "PO210_RAT", "url": "https://www.uniprot.org/uniprot/P11654", "type": "external" } ], "mass": 204159.0, "length": 1886, "protein_name": "Nuclear pore membrane glycoprotein 210", "gene_name": "Nup210", "organism": "Rat", "refseq_name": "nuclear pore membrane glycoprotein 210 precursor", "refseq_ac": [ { "id": "NP_445774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445774", "type": "external" } ], "gene_names_uniprotkb": "Nup210; Gp210; Pom210", "gene_names_refseq": "Nup210; Pom210", "protein_names_uniprotkb": "Nuclear pore membrane glycoprotein 210; Nuclear envelope pore membrane protein POM 210; Nuclear pore protein gp210; Nucleoporin Nup210; POM210; Pore membrane protein of 210 kDa", "protein_names_refseq": "nuclear envelope pore membrane protein POM 210; nuclear pore membrane glycoprotein 210 precursor; nuclear pore membrane glycoprotein 210; nuclear pore protein gp210; nucleoporin Nup210; pore membrane protein of 210 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:58958); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 6, "publication_id_list": "11453980;1281815;17559836;2738089;29393594;8672508", "class_list": "", "function": "Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity., [UniProtKB]; These findings are consistent with the idea that mitotic phosphorylation acts to dissociate gp210 from the structural elements of the nuclear pore complexes., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P11654-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11962-1", "uniprot_id": [ { "id": "GLHA_RAT", "url": "https://www.uniprot.org/uniprot/P11962", "type": "external" } ], "mass": 13453.0, "length": 120, "protein_name": "Glycoprotein hormones alpha chain", "gene_name": "Cga", "organism": "Rat", "refseq_name": "glycoprotein hormones alpha chain precursor", "refseq_ac": [ { "id": "NP_446370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446370", "type": "external" } ], "gene_names_uniprotkb": "Cga; Cga1", "gene_names_refseq": "Cga; Gpa1", "protein_names_uniprotkb": "Glycoprotein hormones alpha chain; Anterior pituitary glycoprotein hormones common subunit alpha; FSH-alpha; Follicle-stimulating hormone alpha chain; Follitropin alpha chain; LSH-alpha; Luteinizing hormone alpha chain; Lutropin alpha chain; TSH-alpha; Thyroid-stimulating hormone alpha chain; Thyrotropin alpha chain", "protein_names_refseq": "FSH-alpha; LSH-alpha; TSH-alpha; anterior pituitary glycoprotein hormones common subunit alpha; follicle-stimulating hormone alpha chain; follitropin alpha chain; glycoprotein hormone alpha subunit; glycoprotein hormones alpha chain precursor; glycoprotein hormones alpha chain; glycoprotein hormones, alpha subunit; luteinizing hormone alpha chain; lutropin alpha chain; pituitary hormone alpha subunit; thyroid-stimulating hormone alpha chain; thyrotropin alpha chain", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612); Leydig cell tumor (Disease Ontology:DOID:2696)", "pathway": " (rno:116700); (R-RNO-193048); (R-RNO-193993); (R-RNO-209822); (R-RNO-209968); (R-RNO-375281); (R-RNO-8866910)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "20352046;21187122;23299500;2467841;6177696", "class_list": "", "function": "Complex interactions between Ahr and Esr alter Prl and luteinizing hormone (LH) synthesis by direct actions in lactotropes and gonadotropes., [RefSeq, PubMed]; Data suggest that FSH (Cga/FSHb) induces clock system in granulosa cells by up-regulation of connexin 43 expression; this suggests that gap junctions are implicated in circadian clock in peripheral oscillators besides central pacemaker., [RefSeq, PubMed]; Histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter Publication Status: Online-Only, [RefSeq, PubMed]; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70516", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0016913 follicle-stimulating hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016914 follicle-stimulating hormone complex;GO:0061696 pituitary gonadotropin complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0032275 luteinizing hormone secretion;GO:0046621 negative regulation of organ growth;GO:0046884 follicle-stimulating hormone secretion;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P11962-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12841-1", "uniprot_id": [ { "id": "FOS_RAT", "url": "https://www.uniprot.org/uniprot/P12841", "type": "external" } ], "mass": 40927.0, "length": 380, "protein_name": "Protein c-Fos", "gene_name": "Fos", "organism": "Rat", "refseq_name": "protein c-Fos", "refseq_ac": [ { "id": "NP_071533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071533", "type": "external" } ], "gene_names_uniprotkb": "Fos", "gene_names_refseq": "Fos; c-fos", "protein_names_uniprotkb": "Protein c-Fos; Cellular oncogene fos; Proto-oncogene c-Fos", "protein_names_refseq": "FBJ osteosarcoma oncogene; c-fos oncogene; protein c-Fos; proto-oncogene c-FOS; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); sleeping sickness (Disease Ontology:DOID:10112); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hypospadias (Disease Ontology:DOID:10892); functional diarrhea (Disease Ontology:DOID:11371); Pick's disease (Disease Ontology:DOID:11870); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); rectal benign neoplasm (Disease Ontology:DOID:1984); Wernicke encephalopathy (Disease Ontology:DOID:2384); morphine dependence (Disease Ontology:DOID:2560); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); amphetamine abuse (Disease Ontology:DOID:670); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); acute myocardial infarction (Disease Ontology:DOID:9408); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:314322); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450341); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "17223854;2105492;29393594;3325886;37598353;37858915;38228055;38338735;7816602;8421668;8622865;9571165", "class_list": "", "function": "Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia and c-fos Activation but Not Experimental Anxiety or Depression in a Menopause Model. Publication Status: Online-Only, [RefSeq, PubMed]; Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons., [RefSeq, PubMed]; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity)., [UniProtKB, PubMed, PubMed]; Social play exclusion model in adolescent rats: Monitoring locomotor and emotional behavior associated with social play and examining c-Fos expression in the brain., [RefSeq, PubMed]; The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FDN1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0003407 neural retina development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P12841-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12969-1", "uniprot_id": [ { "id": "IAPP_RAT", "url": "https://www.uniprot.org/uniprot/P12969", "type": "external" } ], "mass": 10015.0, "length": 93, "protein_name": "Islet amyloid polypeptide", "gene_name": "Iapp", "organism": "Rat", "refseq_name": "islet amyloid polypeptide preproprotein", "refseq_ac": [ { "id": "NP_036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036718", "type": "external" } ], "gene_names_uniprotkb": "Iapp", "gene_names_refseq": "Iapp", "protein_names_uniprotkb": "Islet amyloid polypeptide; Amylin; DAP; Diabetes-associated peptide; IAPP", "protein_names_refseq": "DAP; amylin; diabetes-associated peptide; islet amyloid polypeptide preproprotein", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24476); (R-RNO-419812)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15240697;19360098;19456151;2223885;2357234;2654937;2666169;2668946;2679555;32436936;32587390;34264642;35324283;37126782", "class_list": "", "function": "Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Publication Status: Online-Only, [RefSeq, PubMed]; Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (PubMed:35324283). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (PubMed:35324283)., [UniProtKB, PubMed, UniProtKB]; Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding., [RefSeq, PubMed]; Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats., [RefSeq, PubMed]; Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0005179 hormone activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0043025 neuronal cell body;GO:0016234 inclusion body", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0051260 protein homooligomerization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P12969-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13084-1", "uniprot_id": [ { "id": "NPM_RAT", "url": "https://www.uniprot.org/uniprot/P13084", "type": "external" } ], "mass": 32560.0, "length": 292, "protein_name": "Nucleophosmin", "gene_name": "Npm1", "organism": "Rat", "refseq_name": "nucleophosmin isoform 1", "refseq_ac": [ { "id": "NP_037124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037124", "type": "external" } ], "gene_names_uniprotkb": "Npm1; AABR07041089.1", "gene_names_refseq": "B23NP; Npm1", "protein_names_uniprotkb": "Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin", "protein_names_refseq": "NPM; nucleolar phosphoprotein B23; nucleolar protein B23.1; nucleolar protein NO38; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin isoform 1; numatrin", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 38 (Disease Ontology:DOID:0070068); developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); ovarian cancer (Disease Ontology:DOID:2394); primary ovarian insufficiency (Disease Ontology:DOID:5426); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:25498); (R-RNO-3899300); (R-RNO-606279); (R-RNO-6804115); (R-RNO-8869496); (R-RNO-9833482)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "20075868;2211699;2745414;27510036;29393594;3417636", "class_list": "", "function": "Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes (By similarity). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study suggests that although neurons need NPM1 for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63698;Q64269", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006281 DNA repair;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13084-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14272-1", "uniprot_id": [ { "id": "KLKB1_RAT", "url": "https://www.uniprot.org/uniprot/P14272", "type": "external" } ], "mass": 71274.0, "length": 638, "protein_name": "Plasma kallikrein", "gene_name": "Klkb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klkb1; Klk3; Pk", "gene_names_refseq": "", "protein_names_uniprotkb": "Plasma kallikrein; 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); lupus nephritis (Disease Ontology:DOID:0080162); hypertension (Disease Ontology:DOID:10763); glomerulonephritis (Disease Ontology:DOID:2921); liver cirrhosis (Disease Ontology:DOID:5082); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (R-RNO-1592389); (R-RNO-9855719); (R-RNO-9935598); (R-RNO-9970672)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1993180;2598771", "class_list": "", "function": "The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.21.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.38", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "3.4.21.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.39", "type": "external" }, { "id": "3.4.21.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.59", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:0007597 blood coagulation, intrinsic pathway;GO:0042730 fibrinolysis;GO:0031639 plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P14272-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14600-1", "uniprot_id": [ { "id": "NK1R_RAT", "url": "https://www.uniprot.org/uniprot/P14600", "type": "external" } ], "mass": 46366.0, "length": 407, "protein_name": "Substance-P receptor", "gene_name": "Tacr1", "organism": "Rat", "refseq_name": "substance-P receptor", "refseq_ac": [ { "id": "NP_036799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036799", "type": "external" } ], "gene_names_uniprotkb": "Tacr1; Tac1r", "gene_names_refseq": "Tac1r; Tacr1", "protein_names_uniprotkb": "Substance-P receptor; NK-1 receptor; NK-1R; SPR; Tachykinin receptor 1", "protein_names_refseq": "NK-1 receptor; NK-1R; SPR; neurokinin 1 receptor; substance p receptor; substance-P receptor", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); colitis (Disease Ontology:DOID:0060180); congenital variant of Rett syndrome (Disease Ontology:DOID:0070657); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Rett syndrome (Disease Ontology:DOID:1206); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystitis (Disease Ontology:DOID:1679); asthma (Disease Ontology:DOID:2841); allergic rhinitis (Disease Ontology:DOID:4481); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); central sleep apnea (Disease Ontology:DOID:9220)", "pathway": " (rno:24807); (R-RNO-380095); (R-RNO-416476); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "1370820;1705552;2154852;2478537;31358823;32000757;32540418;32736088;7545030;8746565", "class_list": "", "function": "Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells., [RefSeq, PubMed]; Neurokinin 1 receptor activation in the rat spinal cord maintains latent sensitization, a model of inflammatory and neuropathic chronic pain., [RefSeq, PubMed]; Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K (PubMed:2478537, PubMed:2154852, PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:2478537, PubMed:1370820). Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820)., [UniProtKB, PubMed, PubMed, PubMed]; Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart. Publication Status: Online-Only, [RefSeq, PubMed]; Substance P participates in periodontitis by upregulating HIF-1alpha and RANKL/OPG ratio. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016496 substance P receptor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0035106 operant conditioning;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P14600-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15063-1", "uniprot_id": [ { "id": "MYCB_RAT", "url": "https://www.uniprot.org/uniprot/P15063", "type": "external" } ], "mass": 18317.0, "length": 168, "protein_name": "Protein B-Myc", "gene_name": "Mycb", "organism": "Rat", "refseq_name": "protein B-Myc", "refseq_ac": [ { "id": "NP_001013181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013181", "type": "external" } ], "gene_names_uniprotkb": "Mycb; Bmyc", "gene_names_refseq": "B-myc; Bmyc; Mycb", "protein_names_uniprotkb": "Protein B-Myc", "protein_names_refseq": "Bmyc protein (AA 1-178); avian myelocytomatosis viral (v-myc) related oncogene; protein B-Myc; transforming protein B-Myc", "tax_id": 10116, "disease": "", "pathway": " (rno:311807)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2687773;2850482", "class_list": "", "function": "Seems to act as an inhibitor of cellular proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3HVJ5", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15063-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15257-1", "uniprot_id": [ { "id": "HNF1A_RAT", "url": "https://www.uniprot.org/uniprot/P15257", "type": "external" } ], "mass": 67213.0, "length": 628, "protein_name": "Hepatocyte nuclear factor 1-alpha", "gene_name": "Hnf1a", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 1-alpha", "refseq_ac": [ { "id": "NP_036801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036801", "type": "external" } ], "gene_names_uniprotkb": "Hnf1a; Hnf-1a; Hnf-1; Tcf1", "gene_names_refseq": "HNF1; Hnf1a; LF-B1; Lfb1; Tcf1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; LFB1; Liver-specific transcription factor LF-B1; TCF-1; Transcription factor 1", "protein_names_refseq": "HNF-1-alpha; HNF-1A; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; TCF-1; Transcription factor 1, hepatic; albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1-alpha; liver-specific transcription factor LF-B1", "tax_id": 10116, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); hepatocellular adenoma (Disease Ontology:DOID:0050868); type 1 diabetes mellitus 20 (Disease Ontology:DOID:0110757); maturity-onset diabetes of the young type 3 (Disease Ontology:DOID:0111102); familial hepatic adenoma (Disease Ontology:DOID:0111366); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); gestational diabetes (Disease Ontology:DOID:11714); extrahepatic cholestasis (Disease Ontology:DOID:13619); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); renal cell carcinoma (Disease Ontology:DOID:4450); chromophobe renal cell carcinoma (Disease Ontology:DOID:4471); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); phenylketonuria (Disease Ontology:DOID:9281); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24817)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "1354855;1967225;1970973;1988016;2216777;22673903;2571419;32398139;32833553;7937157;8491172;8491173;9126845", "class_list": "", "function": "Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1alpha and activating FoxO3a. Publication Status: Online-Only, [RefSeq, PubMed]; HMGB1 Inhibits HNF1A to Modulate Liver Fibrogenesis via p65/miR-146b Signaling., [RefSeq, PubMed]; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0035623 renal D-glucose absorption;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:1903799 negative regulation of miRNA processing;GO:2001171 positive regulation of ATP biosynthetic process;GO:0048341 paraxial mesoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P15257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16177-1", "uniprot_id": [ { "id": "NK3R_RAT", "url": "https://www.uniprot.org/uniprot/P16177", "type": "external" } ], "mass": 51107.0, "length": 452, "protein_name": "Neuromedin-K receptor", "gene_name": "Tacr3", "organism": "Rat", "refseq_name": "neuromedin-K receptor", "refseq_ac": [ { "id": "NP_058749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058749", "type": "external" } ], "gene_names_uniprotkb": "Tacr3; Tac3r", "gene_names_refseq": "Nkr; Nmkr; Tac3r; Tacr3", "protein_names_uniprotkb": "Neuromedin-K receptor; NK-3 receptor; NK-3R; NKR; Neurokinin B receptor; Tachykinin receptor 3", "protein_names_refseq": "NK-3 receptor; NK-3R; Neuromedin K receptor (Neurokinin B/Tachikin 3); neurokinin B receptor; neuromedin-K receptor; tachikin receptor 3", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypogonadotropic hypogonadism 11 with or without anosmia (Disease Ontology:DOID:0090071); hypertension (Disease Ontology:DOID:10763); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24808); (R-RNO-380095); (R-RNO-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1370820;2153106;24863620;25825817;26851555;30207304", "class_list": "", "function": "Data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty., [RefSeq, PubMed]; Median preoptic nucleus NK3R neurons facilitate cutaneous vasodilation, an important heat-dissipation effector., [RefSeq, PubMed]; Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P (PubMed:2153106, PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P (PubMed:2153106, PubMed:1370820). Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820)., [UniProtKB, PubMed, PubMed]; Results give support to the involvement of NK3 receptors in the anxiogenic-like actions of SP6-11(C-terminal), where this metabolite seems to behave as an antagonist, in a way similar to SR142801., [RefSeq, PubMed]; The different impacts of diverse long-term exercise intensities on the male pituitary-gonadal axis maybe relay by the various changes in hypothalamic Nkb and Pdyn gene expressions., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004995 tachykinin receptor activity;GO:0016498 neuromedin K receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0032809 neuronal cell body membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0045777 positive regulation of blood pressure;GO:0010460 positive regulation of heart rate;GO:0032355 response to estradiol;GO:0042220 response to cocaine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P16177-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17108-1", "uniprot_id": [ { "id": "IL2_RAT", "url": "https://www.uniprot.org/uniprot/P17108", "type": "external" } ], "mass": 17633.0, "length": 155, "protein_name": "Interleukin-2", "gene_name": "Il2", "organism": "Rat", "refseq_name": "interleukin-2 precursor", "refseq_ac": [ { "id": "NP_446288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446288", "type": "external" } ], "gene_names_uniprotkb": "Il2; Il-2", "gene_names_refseq": "Il2", "protein_names_uniprotkb": "Interleukin-2; IL-2; T-cell growth factor; TCGF", "protein_names_refseq": "IL-2; T-cell growth factor; TCGF; interleukin-2 precursor", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); inflammatory bowel disease (Disease Ontology:DOID:0050589); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); atrial fibrillation (Disease Ontology:DOID:0060224); drug allergy (Disease Ontology:DOID:0060500); colorectal carcinoma (Disease Ontology:DOID:0080199); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); birdshot chorioretinopathy (Disease Ontology:DOID:0111079); sensorineural hearing loss (Disease Ontology:DOID:10003); bacterial infectious disease (Disease Ontology:DOID:104); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); anogenital venereal wart (Disease Ontology:DOID:11168); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); ataxia telangiectasia (Disease Ontology:DOID:12704); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); aggressive periodontitis (Disease Ontology:DOID:1474); limited scleroderma (Disease Ontology:DOID:1577); cystitis (Disease Ontology:DOID:1679); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); viral hepatitis (Disease Ontology:DOID:1884); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); post-traumatic stress disorder (Disease Ontology:DOID:2055); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); brain infarction (Disease Ontology:DOID:3454); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); primary immunodeficiency disease (Disease Ontology:DOID:612); severe combined immunodeficiency (Disease Ontology:DOID:627); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); lung disease (Disease Ontology:DOID:850); bullous pemphigoid (Disease Ontology:DOID:8506); herpes zoster (Disease Ontology:DOID:8536); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); Zellweger syndrome (Disease Ontology:DOID:905); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:116562); (R-RNO-5673001); (R-RNO-9020558); (R-RNO-912526)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2788130;37464198", "class_list": "", "function": "Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells., [UniProtKB, UniProtKB]; Influence of Interleukin-2 and Brain-Derived Neurotrophic Factor (BDNF) on the Size of Myocardial Infarction in Rats with Systemic Inflammatory Response., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031851 kappa-type opioid receptor binding;GO:0043208 glycosphingolipid binding;GO:0005125 cytokine activity;GO:0030246 carbohydrate binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005893 interleukin-2 receptor complex", "go_biological_process": "GO:0002366 leukocyte activation involved in immune response;GO:0038110 interleukin-2-mediated signaling pathway;GO:0046013 regulation of T cell homeostatic proliferation;GO:2000320 negative regulation of T-helper 17 cell differentiation;GO:0032740 positive regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17108-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17490-1", "uniprot_id": [ { "id": "INHA_RAT", "url": "https://www.uniprot.org/uniprot/P17490", "type": "external" } ], "mass": 39497.0, "length": 366, "protein_name": "Inhibin alpha chain", "gene_name": "Inha", "organism": "Rat", "refseq_name": "inhibin alpha chain precursor", "refseq_ac": [ { "id": "NP_036722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036722", "type": "external" } ], "gene_names_uniprotkb": "Inha", "gene_names_refseq": "Inha", "protein_names_uniprotkb": "Inhibin alpha chain", "protein_names_refseq": "inhibin alpha chain precursor; inhibin alpha chain; inhibin alpha subunit", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); Leydig cell tumor (Disease Ontology:DOID:2696); Sertoli-Leydig cell tumor (Disease Ontology:DOID:2997); invasive ductal carcinoma (Disease Ontology:DOID:3008); embryonal carcinoma (Disease Ontology:DOID:3308); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441)", "pathway": " (rno:24504); (R-RNO-1502540); (R-RNO-201451); (R-RNO-209822); (R-RNO-9839406)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "19372236;19464342;19589860;22249524;23767829;2484214;2628729;2829170;3153478;37108077", "class_list": "", "function": "Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes., [RefSeq, PubMed]; Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model., [RefSeq, PubMed]; Inhba overexpression in rat ovary in vivo may change reproductive endocrine function., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland (PubMed:19589860). Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity)., [UniProtKB, UniProtKB, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB, UniProtKB]; The effect of steroidogenic substrates and follicle stimulating hormone on steroid, inhibin A and B, Pro-alphaC and activin A production was evaluated., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0034711 inhibin binding", "go_cellular_component": "GO:0043512 inhibin A complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0042127 regulation of cell population proliferation;GO:0008584 male gonad development;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0001541 ovarian follicle development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P17490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17945-1", "uniprot_id": [ { "id": "HGF_RAT", "url": "https://www.uniprot.org/uniprot/P17945", "type": "external" } ], "mass": 82906.0, "length": 728, "protein_name": "Hepatocyte growth factor", "gene_name": "Hgf", "organism": "Rat", "refseq_name": "hepatocyte growth factor preproprotein", "refseq_ac": [ { "id": "NP_058713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058713", "type": "external" } ], "gene_names_uniprotkb": "Hgf", "gene_names_refseq": "HPTA; Hgf", "protein_names_uniprotkb": "Hepatocyte growth factor; Hepatopoietin-A; SF; Scatter factor", "protein_names_refseq": "SF; hepatocyte growth factor preproprotein; hepatopoeitin-A; hepatopoietin-A; scatter factor", "tax_id": 10116, "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); limb ischemia (Disease Ontology:DOID:0050852); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); graft-versus-host disease (Disease Ontology:DOID:0081267); autosomal recessive nonsyndromic deafness 39 (Disease Ontology:DOID:0110497); keratoconus (Disease Ontology:DOID:10126); dermatomyositis (Disease Ontology:DOID:10223); retinitis pigmentosa (Disease Ontology:DOID:10584); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); myopia (Disease Ontology:DOID:11830); vitiligo (Disease Ontology:DOID:12306); retinopathy of prematurity (Disease Ontology:DOID:13025); angle-closure glaucoma (Disease Ontology:DOID:13550); adult-onset Still's disease (Disease Ontology:DOID:14256); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); arteriosclerosis (Disease Ontology:DOID:2349); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); inverted papilloma (Disease Ontology:DOID:3179); central nervous system disease (Disease Ontology:DOID:331); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); meningioma (Disease Ontology:DOID:3565); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); myositis (Disease Ontology:DOID:633); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal degeneration (Disease Ontology:DOID:8466); localized scleroderma (Disease Ontology:DOID:8472); cholesteatoma (Disease Ontology:DOID:869); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24446); (R-RNO-114608); (R-RNO-1257604); (R-RNO-5673001); (R-RNO-6806942); (R-RNO-6807004); (R-RNO-6811558); (R-RNO-8851805); (R-RNO-8851907); (R-RNO-8865999); (R-RNO-8874081); (R-RNO-8875513); (R-RNO-8875555); (R-RNO-8875656); (R-RNO-8875791); (R-RNO-9734091)", "pathway_count": 16, "publication_count": 8, "publication_id_list": "2139229;2146117;33860459;36293268;36538176;37715611;37985931;8407880", "class_list": "", "function": "Age-related nitration/dysfunction of myogenic stem cell activator HGF., [RefSeq, PubMed]; Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia., [RefSeq, PubMed]; Microvesicles derived from human umbilical cord mesenchyme promote M2 macrophage polarization and ameliorate renal fibrosis following partial nephrectomy via hepatocyte growth factor., [RefSeq, PubMed]; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (By similarity). Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). Activates MAPK signaling following TMPRSS13 cleavage and activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor., [RefSeq, PubMed]; Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 46, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0001889 liver development;GO:0006508 proteolysis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P17945-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000100010000.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18291-1", "uniprot_id": [ { "id": "GRAB_RAT", "url": "https://www.uniprot.org/uniprot/P18291", "type": "external" } ], "mass": 27326.0, "length": 248, "protein_name": "Granzyme B", "gene_name": "Gzmb", "organism": "Rat", "refseq_name": "granzyme B precursor", "refseq_ac": [ { "id": "NP_612526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612526", "type": "external" } ], "gene_names_uniprotkb": "Gzmb", "gene_names_refseq": "Gzmb; RNKP-1", "protein_names_uniprotkb": "Granzyme B; 3.4.21.79; Fragmentin; Natural killer cell protease 1; RNKP-1", "protein_names_refseq": "GLP III; GLP I; GLP-1; fragmentin; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B precursor; granzyme-like protein 1; granzyme-like protein I; natural killer cell protease 1", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); bronchiolitis obliterans (Disease Ontology:DOID:2799); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (rno:171528); (R-RNO-5620971); (R-RNO-75108)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10966646;1727874;1732416;2307850;26432892;29445095;37531918;9765264", "class_list": "", "function": "Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (By similarity). It cleaves after Asp (PubMed:9765264). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9765264). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Exploring the molecular mechanisms of the involvement of GZMB-Caspase-3-GSDME pathway in the progression of rheumatoid arthritis., [RefSeq, PubMed]; Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.79", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0044194 cytolytic granule", "go_biological_process": "GO:0051402 neuron apoptotic process;GO:0017148 negative regulation of translation;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0070269 pyroptotic inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P18291-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18437-1", "uniprot_id": [ { "id": "HMGN2_RAT", "url": "https://www.uniprot.org/uniprot/P18437", "type": "external" } ], "mass": 9366.0, "length": 90, "protein_name": "Non-histone chromosomal protein HMG-17", "gene_name": "Hmgn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hmgn2; Hmg-17; Hmg17; Hmgn2-ps4; LOC100360316", "gene_names_refseq": "", "protein_names_uniprotkb": "Non-histone chromosomal protein HMG-17; High mobility group nucleosome-binding domain-containing protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2169420", "class_list": "", "function": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18437-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18863-1", "uniprot_id": [ { "id": "HXB8_RAT", "url": "https://www.uniprot.org/uniprot/P18863", "type": "external" } ], "mass": 11358.0, "length": 92, "protein_name": "Homeobox protein Hox-B8", "gene_name": "Hoxb8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxb8; Hoxb-8", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-B8; Homeobox protein R1A", "protein_names_refseq": "", "tax_id": 10116, "disease": "trichotillomania (Disease Ontology:DOID:0050587)", "pathway": " (rno:24457)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2907739", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0008344 adult locomotory behavior;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18863-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18864-1", "uniprot_id": [ { "id": "HXB7_RAT", "url": "https://www.uniprot.org/uniprot/P18864", "type": "external" } ], "mass": 24243.0, "length": 219, "protein_name": "Homeobox protein Hox-B7", "gene_name": "Hoxb7", "organism": "Rat", "refseq_name": "homeobox protein Hox-B7", "refseq_ac": [ { "id": "NP_001017480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017480", "type": "external" } ], "gene_names_uniprotkb": "Hoxb7; Hoxb-7; R1b", "gene_names_refseq": "Hox2r1b; Hoxb7; R1b", "protein_names_uniprotkb": "Homeobox protein Hox-B7; Homeobox protein R1B", "protein_names_refseq": "homeobox gene B7; homeobox protein Hox-B7; homeobox protein R1B", "tax_id": 10116, "disease": "invasive ductal carcinoma (Disease Ontology:DOID:3008); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:497985)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2907739", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68FU9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18864-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18866-1", "uniprot_id": [ { "id": "HXC8_RAT", "url": "https://www.uniprot.org/uniprot/P18866", "type": "external" } ], "mass": 13115.0, "length": 108, "protein_name": "Homeobox protein Hox-C8", "gene_name": "Hoxc8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxc8; Hoxc-8", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-C8; Homeobox protein R4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2907739;7702549", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0009952 anterior/posterior pattern specification;GO:0030182 neuron differentiation;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18866-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19804-1", "uniprot_id": [ { "id": "NDKB_RAT", "url": "https://www.uniprot.org/uniprot/P19804", "type": "external" } ], "mass": 17283.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "Nme2", "organism": "Rat", "refseq_name": "nucleoside diphosphate kinase B", "refseq_ac": [ { "id": "NP_114021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114021", "type": "external" } ], "gene_names_uniprotkb": "Nme2; Nme2-ps1", "gene_names_refseq": "NDKB; NDPK B; NDPK2; Nme2; nm23-2; p18-12d", "protein_names_uniprotkb": "Nucleoside diphosphate kinase B; 2.7.13.3; 2.7.4.6; Histidine protein kinase NDKB; NDP kinase B; NDPK B; NDPK2; Nucleoside diphosphate kinases 2; P18", "protein_names_refseq": "NDK B; NDP kinase B; NDP kinase alpha; P18; expressed in non-metastatic cells 2; histidine protein kinase NDKB; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleoside diphosphate kinases 2", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); teratoma (Disease Ontology:DOID:3307); ovarian carcinoma (Disease Ontology:DOID:4001); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:83782); (R-RNO-499943); (R-RNO-6798695); (R-RNO-9748787); (R-RNO-9755088)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "1316151;1321145;17532299;2168422;22817458;23368879;2832402;34502162", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:2832402). Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (By similarity). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (By similarity). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells. Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling. In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription. G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (By similarity). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (By similarity). Also negatively regulates Rho activity by interacting with AKAP13/LBC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; PuF may regulate the APP gene promoter Publication Status: Online-Only, [RefSeq, PubMed]; The sites of NDPK binding to the outer mitochondrial membrane are not identical to those of hexokinase and glycerol kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity;GO:0005504 fatty acid binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P19804-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20059-1", "uniprot_id": [ { "id": "HEMO_RAT", "url": "https://www.uniprot.org/uniprot/P20059", "type": "external" } ], "mass": 51351.0, "length": 460, "protein_name": "Hemopexin", "gene_name": "Hpx", "organism": "Rat", "refseq_name": "hemopexin precursor", "refseq_ac": [ { "id": "NP_445770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445770", "type": "external" } ], "gene_names_uniprotkb": "Hpx", "gene_names_refseq": "Hpxn; Hpx", "protein_names_uniprotkb": "Hemopexin", "protein_names_refseq": "hemopexin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:58917); (R-RNO-2168880)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1587840;1599480;1988069;22486875;28596380;32804709;3421961;34563046", "class_list": "", "function": "Adenoviral transfer of hemopexin gene attenuates oxidative stress and apoptosis in cultured primary cortical neuron cell exposed to blood clot., [RefSeq, PubMed]; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation., [UniProtKB]; Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro., [RefSeq, PubMed]; Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli. Publication Status: Online-Only, [RefSeq, PubMed]; Hemopexin was identified as upregulated protein in the small intestine exposed to indomethacin., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKB4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015232 heme transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0006879 intracellular iron ion homeostasis;GO:0020027 hemoglobin metabolic process;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20059-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20096-1", "uniprot_id": [ { "id": "IL4_RAT", "url": "https://www.uniprot.org/uniprot/P20096", "type": "external" } ], "mass": 16247.0, "length": 147, "protein_name": "Interleukin-4", "gene_name": "Il4", "organism": "Rat", "refseq_name": "interleukin-4 precursor", "refseq_ac": [ { "id": "NP_958427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958427", "type": "external" } ], "gene_names_uniprotkb": "Il4; Il-4", "gene_names_refseq": "Il4e12; Il4", "protein_names_uniprotkb": "Interleukin-4; B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IL-4; Lymphocyte stimulatory factor 1", "protein_names_refseq": "B-cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IL-4; interleukin-4 precursor; lymphocyte stimulatory factor 1", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); biliary tract benign neoplasm (Disease Ontology:DOID:0050625); alopecia universalis (Disease Ontology:DOID:0050634); stroke (Disease Ontology:DOID:0051061); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); dihydrolipoamide dehydrogenase deficiency (Disease Ontology:DOID:0061204); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pelvic inflammatory disease (Disease Ontology:DOID:1003); trypanosomiasis (Disease Ontology:DOID:10113); dermatomyositis (Disease Ontology:DOID:10223); Alzheimer's disease (Disease Ontology:DOID:10652); nephritis (Disease Ontology:DOID:10952); anogenital venereal wart (Disease Ontology:DOID:11168); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); cognitive disorder (Disease Ontology:DOID:1561); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); irritant dermatitis (Disease Ontology:DOID:2772); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); autoimmune thyroiditis (Disease Ontology:DOID:7188); herpes zoster (Disease Ontology:DOID:8536); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); leishmaniasis (Disease Ontology:DOID:9065); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); toxocariasis (Disease Ontology:DOID:9790)", "pathway": " (rno:287287); (R-RNO-6785807)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1903705;1983334;36723732;37982769;38315435", "class_list": "", "function": "Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress., [RefSeq, PubMed]; Neonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4., [UniProtKB, UniProtKB]; Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005136 interleukin-4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0016516 interleukin-4 receptor complex", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0002677 negative regulation of chronic inflammatory response;GO:0010633 negative regulation of epithelial cell migration;GO:0032736 positive regulation of interleukin-13 production;GO:0035771 interleukin-4-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20266-1", "uniprot_id": [ { "id": "PO4F1_RAT", "url": "https://www.uniprot.org/uniprot/P20266", "type": "external" } ], "mass": 43275.0, "length": 420, "protein_name": "POU domain, class 4, transcription factor 1", "gene_name": "Pou4f1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pou4f1; Brn-3; Brn3a; Brn3", "gene_names_refseq": "", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 1; Brain-3A; Brain-specific homeobox/POU domain protein 3A; Brn-3A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6804759)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10640682;11053412;1383937;2739723;8835784", "class_list": "", "function": "Able to act as a transcription factor, cannot regulate the expression of the same subset of genes as isoform 1. Does not have an antiapoptotic effect on neuronal cells., [UniProtKB, UniProtKB]; Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages (PubMed:11053412). It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Activates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XM4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0051020 GTPase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043005 neuron projection;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0060384 innervation;GO:0048880 sensory system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001967 suckling behavior;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20266-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20607-1", "uniprot_id": [ { "id": "IL6_RAT", "url": "https://www.uniprot.org/uniprot/P20607", "type": "external" } ], "mass": 24357.0, "length": 211, "protein_name": "Interleukin-6", "gene_name": "Il6", "organism": "Rat", "refseq_name": "interleukin-6 precursor", "refseq_ac": [ { "id": "NP_036721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036721", "type": "external" } ], "gene_names_uniprotkb": "Il6; Il-6", "gene_names_refseq": "ILg6; Ifnb2; Il6", "protein_names_uniprotkb": "Interleukin-6; IL-6", "protein_names_refseq": "IL-6; Interleukin 6 (interferon, beta 2); interleukin-6 precursor", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); biliary tract benign neoplasm (Disease Ontology:DOID:0050625); small cell carcinoma (Disease Ontology:DOID:0050685); chorioamnionitis (Disease Ontology:DOID:0050697); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); aortic valve disease 1 (Disease Ontology:DOID:0080333); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); transverse myelitis (Disease Ontology:DOID:0080743); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); dry eye syndrome (Disease Ontology:DOID:10140); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); anogenital venereal wart (Disease Ontology:DOID:11168); spondyloarthropathy (Disease Ontology:DOID:1123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); prediabetes syndrome (Disease Ontology:DOID:11716); iron deficiency anemia (Disease Ontology:DOID:11758); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); ataxia telangiectasia (Disease Ontology:DOID:12704); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); quadriplegia (Disease Ontology:DOID:12835); autistic disorder (Disease Ontology:DOID:12849); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); keratoconjunctivitis sicca (Disease Ontology:DOID:12895); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); eclampsia (Disease Ontology:DOID:13593); polyneuropathy (Disease Ontology:DOID:1389); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); major depressive disorder (Disease Ontology:DOID:1470); aggressive periodontitis (Disease Ontology:DOID:1474); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); neovascular glaucoma (Disease Ontology:DOID:1687); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); hepatitis C (Disease Ontology:DOID:1883); hypogonadism (Disease Ontology:DOID:1924); rectum cancer (Disease Ontology:DOID:1993); hyperinsulinism (Disease Ontology:DOID:2018); hepatitis B (Disease Ontology:DOID:2043); multiple sclerosis (Disease Ontology:DOID:2377); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gingivitis (Disease Ontology:DOID:3087); spinal cord disease (Disease Ontology:DOID:319); central nervous system disease (Disease Ontology:DOID:331); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); conjunctival disease (Disease Ontology:DOID:4251); macular retinal edema (Disease Ontology:DOID:4449); keratitis (Disease Ontology:DOID:4677); cholangiocarcinoma (Disease Ontology:DOID:4947); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); retinal detachment (Disease Ontology:DOID:5327); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); cochlear disease (Disease Ontology:DOID:5463); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); periodontitis (Disease Ontology:DOID:824); peritonitis (Disease Ontology:DOID:8283); corneal ulcer (Disease Ontology:DOID:8463); retinal artery occlusion (Disease Ontology:DOID:8483); lung disease (Disease Ontology:DOID:850); Hodgkin's lymphoma (Disease Ontology:DOID:8567); Kaposi's sarcoma (Disease Ontology:DOID:8632); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); alcoholic gastritis (Disease Ontology:DOID:8680); Crohn's disease (Disease Ontology:DOID:8778); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); epididymitis (Disease Ontology:DOID:9402); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415); steatotic liver disease (Disease Ontology:DOID:9452); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24498); (R-RNO-1059683); (R-RNO-110056); (R-RNO-112411); (R-RNO-381426); (R-RNO-8957275); (R-RNO-9958825)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "23955712;2789217;37629166;37914358;38602915;39000275", "class_list": "", "function": "Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration. Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection. Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis., [RefSeq, PubMed]; IL-6/gp130 signaling in CD4[+] T cells drives the pathogenesis of pulmonary hypertension., [RefSeq, PubMed]; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B-cells into immunoglolin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Together with IL21, controls the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. Required to drive naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells. Also required for proliferation of myeloma cells and the survival of plasmablast cells., [UniProtKB, UniProtKB]; Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin 6 (IL-6) Regulates GABAA Receptors in the Dorsomedial Hypothalamus Nucleus (DMH) through Activation of the JAK/STAT Pathway to Affect Heart Rate Variability in Stressed Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 135, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding", "go_cellular_component": "GO:0005896 interleukin-6 receptor complex;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:2000866 positive regulation of estradiol secretion;GO:0002384 hepatic immune response;GO:0031294 lymphocyte costimulation;GO:0048635 negative regulation of muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20607-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20759-1", "uniprot_id": [ { "id": "IGHG1_RAT", "url": "https://www.uniprot.org/uniprot/P20759", "type": "external" } ], "mass": 35946.0, "length": 326, "protein_name": "Ig gamma-1 chain C region", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-1 chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-173623); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-977606)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "3016742;3149946", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane;GO:0042571 immunoglobulin complex, circulating;GO:0071735 IgG immunoglobulin complex", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0019731 antibacterial humoral response;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:0002250 adaptive immune response;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20759-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20760-1", "uniprot_id": [ { "id": "IGG2A_RAT", "url": "https://www.uniprot.org/uniprot/P20760", "type": "external" } ], "mass": 35186.0, "length": 322, "protein_name": "Ig gamma-2A chain C region", "gene_name": "Igg-2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Igg-2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-2A chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "3016742;3149946;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20760-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20762-1", "uniprot_id": [ { "id": "IGG2C_RAT", "url": "https://www.uniprot.org/uniprot/P20762", "type": "external" } ], "mass": 36572.0, "length": 329, "protein_name": "Ig gamma-2C chain C region", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig gamma-2C chain C region", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-173623); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-977606)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "24090084;3127222", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0042571 immunoglobulin complex, circulating", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20762-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21743-1", "uniprot_id": [ { "id": "IBP1_RAT", "url": "https://www.uniprot.org/uniprot/P21743", "type": "external" } ], "mass": 29684.0, "length": 272, "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "Igfbp1", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_037276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037276", "type": "external" } ], "gene_names_uniprotkb": "Igfbp1; Igfbp-1", "gene_names_refseq": "IBP1; IGF-BP25; IGFBA; Igfbp1", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1", "protein_names_refseq": "IBP-1; IGF-binding protein 1; IGFBP-1; insulin-like growth factor-binding protein 1 precursor; placental protein 12", "tax_id": 10116, "disease": "diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:25685); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12111802;1283442;1691820;1705004;17645865;20345750;2164920;22805023;34531382;38759370;7514892", "class_list": "", "function": "Age-related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression., [RefSeq, PubMed]; IGFBP1 stabilizes Umod expression through m6A modification to inhibit the occurrence and development of cystitis by blocking NF-kappaB and ERK signaling pathways., [RefSeq, PubMed]; In simulated sleep apnea hypopnea syndrome, intermittent hypoxia in young rats does not cause physical growth retardation, but serum IGF-1 and IGFBP-3 levels decreased with the increase of hypoxia and decline of oxygen saturation., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:12111802). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (PubMed:34531382)., [UniProtKB, UniProtKB, PubMed, PubMed]; Up-regulation of IGFBP-1 in oligodendrocytes in multiple sclerosis may serve two functions: (i) regulate IGF-1 actions, (ii) exert IGF-independent effects through its RGD sequence, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0006006 glucose metabolic process;GO:0032868 response to insulin;GO:0008286 insulin receptor signaling pathway;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P21743-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21996-1", "uniprot_id": [ { "id": "PNEU_RAT", "url": "https://www.uniprot.org/uniprot/P21996", "type": "external" } ], "mass": 1048.0, "length": 10, "protein_name": "Pneumadin", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Pneumadin; PNM", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2274681", "class_list": "", "function": "This antidiuretic peptide triggers the release of ADH., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P21996-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23269-1", "uniprot_id": [ { "id": "O1496_RAT", "url": "https://www.uniprot.org/uniprot/P23269", "type": "external" } ], "mass": 35247.0, "length": 310, "protein_name": "Olfactory receptor 1496", "gene_name": "Olr1496", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Olr1496", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 1496; Olfactory receptor-like protein I3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23269-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23711-1", "uniprot_id": [ { "id": "HMOX2_RAT", "url": "https://www.uniprot.org/uniprot/P23711", "type": "external" } ], "mass": 35762.0, "length": 315, "protein_name": "Heme oxygenase 2", "gene_name": "Hmox2", "organism": "Rat", "refseq_name": "heme oxygenase 2", "refseq_ac": [ { "id": "NP_001264002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264002", "type": "external" } ], "gene_names_uniprotkb": "Hmox2", "gene_names_refseq": "Hmox2; Ho-2", "protein_names_uniprotkb": "Heme oxygenase 2; 1.14.14.18; HO-2", "protein_names_refseq": "heme oxygenase (decycling) 2; heme oxygenase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:79239); (R-RNO-189483); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-917937); (R-RNO-9707564)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "1575508;2185251;22673903;24163720;28088559;30132448;3343248;34223768;34984919;8112599", "class_list": "", "function": "Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1., [RefSeq, PubMed]; Role of heme oxygenase in the regulation of the renal hemodynamics in a model of sex-dependent programmed hypertension by maternal diabetes., [RefSeq, PubMed]; The increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age., [RefSeq, PubMed]; This experiments shown here indicate that HO-2 and HO-1 are differentially regulated across sexual experience and that the two CO-producing enzymes are expressed in distinct but overlapping populations of cells in medial preoptic area., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0042167 heme catabolic process;GO:0006788 heme oxidation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P23711-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23764-1", "uniprot_id": [ { "id": "GPX3_RAT", "url": "https://www.uniprot.org/uniprot/P23764", "type": "external" } ], "mass": 25424.0, "length": 226, "protein_name": "Glutathione peroxidase 3", "gene_name": "Gpx3", "organism": "Rat", "refseq_name": "glutathione peroxidase 3 precursor", "refseq_ac": [ { "id": "NP_071970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071970", "type": "external" } ], "gene_names_uniprotkb": "Gpx3", "gene_names_refseq": "GPx-3; GPx-P; GSHPx-3; GSHPx-P; Gpx3; Gpxp", "protein_names_uniprotkb": "Glutathione peroxidase 3; 1.11.1.9; GPx-3; GPx-P; GSHPx-3; GSHPx-P; Plasma glutathione peroxidase", "protein_names_refseq": "glutathione peroxidase 3 precursor; plasma glutathione peroxidase", "tax_id": 10116, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); colorectal adenoma (Disease Ontology:DOID:0050860); stroke (Disease Ontology:DOID:0051061); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); stomach cancer (Disease Ontology:DOID:10534); mild pre-eclampsia (Disease Ontology:DOID:10590); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrotic syndrome (Disease Ontology:DOID:1184); spermatic cord torsion (Disease Ontology:DOID:11996); male infertility (Disease Ontology:DOID:12336); cardiovascular system disease (Disease Ontology:DOID:1287); severe pre-eclampsia (Disease Ontology:DOID:13129); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); congenital heart disease (Disease Ontology:DOID:1682); atherosclerosis (Disease Ontology:DOID:1936); rectum cancer (Disease Ontology:DOID:1993); transient cerebral ischemia (Disease Ontology:DOID:224); endometrial adenocarcinoma (Disease Ontology:DOID:2870); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); systemic scleroderma (Disease Ontology:DOID:418); esophagus adenocarcinoma (Disease Ontology:DOID:4914); gallbladder carcinoma (Disease Ontology:DOID:4948); esophageal cancer (Disease Ontology:DOID:5041); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); Barrett's adenocarcinoma (Disease Ontology:DOID:7941); lung disease (Disease Ontology:DOID:850); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64317); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1939013;37633909;37761814", "class_list": "", "function": "Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate. Publication Status: Online-Only, [RefSeq, PubMed]; Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns. Publication Status: Online-Only, [RefSeq, PubMed]; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is predominantly expressed in rat kidney, which appears to be the major source of the enzyme in plasma. Dysregulation of this isozyme has been associated with obesity-related metabolic complications. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6H2", "ec_number_list": [ { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0008430 selenium binding;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0042744 hydrogen peroxide catabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23897-1", "uniprot_id": [ { "id": "GUC2C_RAT", "url": "https://www.uniprot.org/uniprot/P23897", "type": "external" } ], "mass": 123467.0, "length": 1072, "protein_name": "Guanylyl cyclase C", "gene_name": "Gucy2c", "organism": "Rat", "refseq_name": "guanylyl cyclase C precursor", "refseq_ac": [ { "id": "NP_037302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037302", "type": "external" } ], "gene_names_uniprotkb": "Gucy2c; Guc2c", "gene_names_refseq": "GCC; Gucy2c", "protein_names_uniprotkb": "Guanylyl cyclase C; 4.6.1.2; GC-C; Heat-stable enterotoxin receptor; Intestinal guanylate cyclase; STA receptor", "protein_names_refseq": "GC-C; Guanylate cyclase 2C (heat stable enterotoxin receptor); STA receptor; guanylyl cyclase C precursor; guanylyl cyclase C; heat-stable enterotoxin receptor; intestinal guanylate cyclase", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); congenital diarrhea 6 (Disease Ontology:DOID:0060780); arthus reaction (Disease Ontology:DOID:1556); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25711); (R-RNO-8935690)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1701694;19648115;21106860;23081987;26249840;29097254", "class_list": "", "function": "Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors., [RefSeq, PubMed]; Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1701694). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1701694)., [UniProtKB, PubMed]; The macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity, [RefSeq, PubMed]; The role of the linker region in receptor guanylyl cyclases, [RefSeq, PubMed]; These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance, [RefSeq, PubMed]; These studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0015643 toxic substance binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0042127 regulation of cell population proliferation;GO:0009636 response to toxic substance;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23897-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23899-1", "uniprot_id": [ { "id": "HNF1B_RAT", "url": "https://www.uniprot.org/uniprot/P23899", "type": "external" } ], "mass": 61371.0, "length": 557, "protein_name": "Hepatocyte nuclear factor 1-beta", "gene_name": "Hnf1b", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 1-beta isoform 2", "refseq_ac": [ { "id": "NP_037235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037235", "type": "external" } ], "gene_names_uniprotkb": "Hnf1b; Hnf-1b; Tcf2", "gene_names_refseq": "HNF-1-beta; HNF-1B; Hnf1b; LF-B3; Tcf2; VHNF1", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; TCF-2; Transcription factor 2; Variant hepatic nuclear factor 1; vHNF1", "protein_names_refseq": "Transcription factor 2, hepatic; hepatocyte nuclear factor 1-beta isoform 2; hepatocyte nuclear factor 1-beta; variant hepatic nuclear factor 1", "tax_id": 10116, "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); renal cysts and diabetes syndrome (Disease Ontology:DOID:0111101); pancreas disease (Disease Ontology:DOID:26); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25640)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;1673926;22673903;22759397", "class_list": "", "function": "HNF-1beta is upregulated after ischemia/reperfusion renal tubule injury in proximal tubular cells in vivo. HNF-1beta controls cellular proliferation and tubule formation by regulating SOCS-3 expression and STAT3 activation, [RefSeq, PubMed]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0061017 hepatoblast differentiation;GO:0048806 genitalia development;GO:0060429 epithelium development;GO:0001714 endodermal cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23899-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24053-1", "uniprot_id": [ { "id": "NMBR_RAT", "url": "https://www.uniprot.org/uniprot/P24053", "type": "external" } ], "mass": 43535.0, "length": 390, "protein_name": "Neuromedin-B receptor", "gene_name": "Nmbr", "organism": "Rat", "refseq_name": "neuromedin-B receptor", "refseq_ac": [ { "id": "NP_036931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036931", "type": "external" } ], "gene_names_uniprotkb": "Nmbr", "gene_names_refseq": "NMB-R; Nmbr", "protein_names_uniprotkb": "Neuromedin-B receptor; NMB-R; Neuromedin-B-preferring bombesin receptor", "protein_names_refseq": "neuromedin-B receptor; neuromedin-B-preferring bombesin receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:25264); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1848080;26855425;8391296", "class_list": "", "function": "Peptidergic pathways comprise the core of a sigh control circuit that integrates physiological and perhaps emotional input to transform normal breaths into sighs, [RefSeq, PubMed]; Receptor for neuromedin-B (PubMed:1848080). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004946 bombesin receptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032715 negative regulation of interleukin-6 production;GO:0090290 positive regulation of osteoclast proliferation;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24053-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24392-1", "uniprot_id": [ { "id": "PEX2_RAT", "url": "https://www.uniprot.org/uniprot/P24392", "type": "external" } ], "mass": 34768.0, "length": 305, "protein_name": "Peroxisome biogenesis factor 2", "gene_name": "Pex2", "organism": "Rat", "refseq_name": "peroxisome biogenesis factor 2 isoform 1", "refseq_ac": [ { "id": "NP_001375433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001375433", "type": "external" } ], "gene_names_uniprotkb": "Pex2; Paf1; Pmp35; Pxmp3", "gene_names_refseq": "Pex2; Pxmp3", "protein_names_uniprotkb": "Peroxisome biogenesis factor 2; 2.3.2.27; 2.3.2.36; PAF-1; Peroxin-2; Peroxisomal membrane protein 3; Peroxisome assembly factor 1", "protein_names_refseq": "PAF-1; peroxin-2; peroxisomal membrane protein 3, 35 kDa; peroxisome assembly factor 1; peroxisome biogenesis factor 2 isoform 1; peroxisome biogenesis factor 2", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 5A (Disease Ontology:DOID:0080480); Peroxisome biogenesis disorder 5B (Disease Ontology:DOID:0081434); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (rno:29534); (R-RNO-8866654); (R-RNO-9033241); (R-RNO-9603798)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1750930;8035823", "class_list": "", "function": "E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:1750930). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol (By similarity). Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70. Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63733", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0000151 ubiquitin ligase complex;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0007399 nervous system development;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24392-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24594-1", "uniprot_id": [ { "id": "IBP5_RAT", "url": "https://www.uniprot.org/uniprot/P24594", "type": "external" } ], "mass": 30298.0, "length": 271, "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "Igfbp5", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 5 precursor", "refseq_ac": [ { "id": "NP_036949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036949", "type": "external" } ], "gene_names_uniprotkb": "Igfbp5; Igfbp-5", "gene_names_refseq": "IGF-BP5; Igfbp5", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5", "protein_names_refseq": "IBP-5; IGF-binding protein 5; IGFBP-5; insulin-like growth factor-binding protein 5 precursor", "tax_id": 10116, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003); microcephaly (Disease Ontology:DOID:10907); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (rno:25285); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1709938;23417767;31310371;31926246;33035436;35821045;7679898", "class_list": "", "function": "Homocysteine downregulates cardiac homeobox transcription factor NKX2.5 via IGFBP5., [RefSeq, PubMed]; IGFBP5 was determined as a target of miR-24-3p, and IGFBP5 knockdown induced effects on NP cells similar to those induced by miR-24-3p, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:23417767). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis., [RefSeq, PubMed]; The expression of IGFBP-5 in the reproductive axis and effect on the onset of puberty in female rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0001968 fibronectin binding;GO:0048018 receptor ligand activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042567 insulin-like growth factor ternary complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0040008 regulation of growth;GO:0048286 lung alveolus development;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24594-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25427-1", "uniprot_id": [ { "id": "NGF_RAT", "url": "https://www.uniprot.org/uniprot/P25427", "type": "external" } ], "mass": 27010.0, "length": 241, "protein_name": "Beta-nerve growth factor", "gene_name": "Ngf", "organism": "Rat", "refseq_name": "beta-nerve growth factor precursor", "refseq_ac": [ { "id": "NP_001263984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263984", "type": "external" } ], "gene_names_uniprotkb": "Ngf; Ngfb", "gene_names_refseq": "Ngfb; Ngf; beta-NGF", "protein_names_uniprotkb": "Beta-nerve growth factor; Beta-NGF", "protein_names_refseq": "beta-nerve growth factor precursor; beta-nerve growth factor; nerve growth factor (beta polypeptide); pro-nerve growth factor long", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); withdrawal disorder (Disease Ontology:DOID:0060001); hereditary sensory and autonomic neuropathy type 5 (Disease Ontology:DOID:0070145); overactive bladder syndrome (Disease Ontology:DOID:0070355); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic asthma (Disease Ontology:DOID:0080809); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); separation anxiety disorder (Disease Ontology:DOID:10685); hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); neurogenic bladder (Disease Ontology:DOID:12143); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); pulmonary sarcoidosis (Disease Ontology:DOID:13406); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); atherosclerosis (Disease Ontology:DOID:1936); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); interstitial lung disease (Disease Ontology:DOID:3082); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); myofascial pain syndrome (Disease Ontology:DOID:431); rhinitis (Disease Ontology:DOID:4483); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); diabetic retinopathy (Disease Ontology:DOID:8947); degenerative disc disease (Disease Ontology:DOID:90); hyperhomocysteinemia (Disease Ontology:DOID:9279); bacterial meningitis (Disease Ontology:DOID:9470); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:310738); (R-RNO-1257604); (R-RNO-167060); (R-RNO-170968); (R-RNO-170984); (R-RNO-177504); (R-RNO-187042); (R-RNO-198203); (R-RNO-205017); (R-RNO-205025); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-209563)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "2025430;3184206;38637413;38725127;38875221;38926110", "class_list": "", "function": "EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells., [RefSeq, PubMed]; Effects of TNF-alpha on Behaviour and Inflammation in Rats with Rotator Cuff Injury through NGF., [RefSeq, PubMed]; Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; NGF effects promote the maturation of rat pancreatic beta cells by regulating GLUT2 levels and distribution, and glucokinase activity. Publication Status: Online-Only, [RefSeq, PubMed]; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 55, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen;GO:0031904 endosome lumen", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:2000648 positive regulation of stem cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25427-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26824-1", "uniprot_id": [ { "id": "PAR1_RAT", "url": "https://www.uniprot.org/uniprot/P26824", "type": "external" } ], "mass": 48281.0, "length": 432, "protein_name": "Proteinase-activated receptor 1", "gene_name": "F2r", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F2r; Par1", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteinase-activated receptor 1; PAR-1; Thrombin receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); Williams-Beuren syndrome (Disease Ontology:DOID:1928); brain ischemia (Disease Ontology:DOID:2316); brain edema (Disease Ontology:DOID:4724)", "pathway": " (rno:25439); (R-RNO-375276); (R-RNO-416476); (R-RNO-456926); (R-RNO-9769739)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1324917;15145074", "class_list": "", "function": "High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:15145074). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (PubMed:15145074). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (By similarity). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0031094 platelet dense tubular network;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0032651 regulation of interleukin-1 beta production;GO:1900134 negative regulation of renin secretion into blood stream;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27213-1", "uniprot_id": [ { "id": "PTPS_RAT", "url": "https://www.uniprot.org/uniprot/P27213", "type": "external" } ], "mass": 16241.0, "length": 144, "protein_name": "6-pyruvoyl tetrahydrobiopterin synthase", "gene_name": "Pts", "organism": "Rat", "refseq_name": "6-pyruvoyl tetrahydrobiopterin synthase isoform 1", "refseq_ac": [ { "id": "NP_058916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058916", "type": "external" } ], "gene_names_uniprotkb": "Pts", "gene_names_refseq": "Pts", "protein_names_uniprotkb": "6-pyruvoyl tetrahydrobiopterin synthase; 4.2.3.12; PTP synthase; PTPS", "protein_names_refseq": "6-pyruvoyl tetrahydrobiopterin synthase isoform 1; 6-pyruvoyl tetrahydrobiopterin synthase; 6-pyruvoyltetrahydropterin synthase; PTP synthase; PTPS", "tax_id": 10116, "disease": "BH4-deficient hyperphenylalaninemia A (Disease Ontology:DOID:0090106); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (R-RNO-1474151)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10024455;1939130;8137809", "class_list": "", "function": "Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.12", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003874 6-pyruvoyltetrahydropterin synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0046146 tetrahydrobiopterin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P27213-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27471-1", "uniprot_id": [ { "id": "KLRBA_RAT", "url": "https://www.uniprot.org/uniprot/P27471", "type": "external" } ], "mass": 24551.0, "length": 223, "protein_name": "Killer cell lectin-like receptor subfamily B member 1A", "gene_name": "Klrb1a", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily B member 1A", "refseq_ac": [ { "id": "NP_001010964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010964", "type": "external" } ], "gene_names_uniprotkb": "Klrb1a; Nkrp1a", "gene_names_refseq": "Klrb1a; NKR-P1A; Nkrp1a", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1A; Antigen 3.2.3; CD161 antigen-like family member A; NKR-P1 3.2.3; NKR-P1A; Natural killer cell surface protein P1-3.2.3", "protein_names_refseq": "CD161 antigen-like family member A; NKR-P1 3.2.3; antigen 3.2.3; killer cell lectin like receptor B1A; killer cell lectin-like receptor subfamily B member 1A; natural killer cell surface protein P1-3.2.3", "tax_id": 10116, "disease": "", "pathway": " (rno:362443); (R-RNO-198933)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12618485;17462921;2399464;30587601;9022000", "class_list": "", "function": "Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161(+)) cells play a major role in the destruction of cancer cells during Spontaneous regression tumours in this Lewis rat model, [RefSeq, PubMed]; Plays a stimulatory role on natural killer (NK) cell cytotoxicity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4KW96;A4KWA2", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P27471-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29188-1", "uniprot_id": [ { "id": "NEUAX_RAT", "url": "https://www.uniprot.org/uniprot/P29188", "type": "external" } ], "mass": 2062.0, "length": 20, "protein_name": "Putative N-acylneuraminate cytidylyltransferase", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative N-acylneuraminate cytidylyltransferase; 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1577759", "class_list": "", "function": "May play an important role in the regulation of sialic acid metabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29188-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29348-1", "uniprot_id": [ { "id": "GNAT3_RAT", "url": "https://www.uniprot.org/uniprot/P29348", "type": "external" } ], "mass": 40294.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-3", "gene_name": "Gnat3", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-3", "refseq_ac": [ { "id": "NP_775162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775162", "type": "external" } ], "gene_names_uniprotkb": "Gnat3; Gnat-3", "gene_names_refseq": "Gnat3; Hg1e; gnat-3", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-3; Gustducin alpha-3 chain", "protein_names_refseq": "guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustducin alpha-3 chain; heterotrimeric guanine nucleotide-binding protein 1e", "tax_id": 10116, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:286924); (R-RNO-170670); (R-RNO-392170); (R-RNO-418594); (R-RNO-9009391); (R-RNO-9717207)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10052456;10407021;10576254;10940948;11447270;15561439;15654652;1608467;17021831;21566335;28782537;33677835;7596440;7626029;8692869;9092606", "class_list": "", "function": "Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Also functions as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications for the prevention and treatment of malabsorption syndromes and diet-related disorders including diabetes and obesity., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat., [RefSeq, PubMed]; Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each)., [RefSeq, PubMed]; The staining protocols, especially the fixation time, cause discrepancies in gustducin immunoreactivities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0001669 acrosomal vesicle;GO:0005930 axoneme", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035094 response to nicotine;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007603 phototransduction, visible light;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P29348-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29411-1", "uniprot_id": [ { "id": "KAD3_RAT", "url": "https://www.uniprot.org/uniprot/P29411", "type": "external" } ], "mass": 25438.0, "length": 227, "protein_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "gene_name": "Ak3", "organism": "Rat", "refseq_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "refseq_ac": [ { "id": "NP_037350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037350", "type": "external" } ], "gene_names_uniprotkb": "Ak3; AK3; Ak3l1", "gene_names_refseq": "Ak3", "protein_names_uniprotkb": "GTP:AMP phosphotransferase AK3, mitochondrial; 2.7.4.10; Adenylate kinase 3 alpha-like 1; Adenylate kinase 3; Adenylate kinase isozyme 3", "protein_names_refseq": "AK 3; GTP:AMP phosphotransferase AK3, mitochondrial; GTP:AMP phosphotransferase, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase isozyme 3", "tax_id": 10116, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:26956); (R-RNO-983231)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8468325", "class_list": "", "function": "Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities., [UniProtKB, HAMAP]; Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity. Could also use ITP as phosphate donor. Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046041 ITP metabolic process;GO:0046051 UTP metabolic process;GO:0046060 dATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29411-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30152-1", "uniprot_id": [ { "id": "NGAL_RAT", "url": "https://www.uniprot.org/uniprot/P30152", "type": "external" } ], "mass": 22476.0, "length": 198, "protein_name": "Neutrophil gelatinase-associated lipocalin", "gene_name": "Lcn2", "organism": "Rat", "refseq_name": "neutrophil gelatinase-associated lipocalin precursor", "refseq_ac": [ { "id": "NP_570097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570097", "type": "external" } ], "gene_names_uniprotkb": "Lcn2", "gene_names_refseq": "Lcn2; Sip24", "protein_names_uniprotkb": "Neutrophil gelatinase-associated lipocalin; Alpha-2-microglobulin-related protein; Alpha-2U globulin-related protein; Lipocalin 24p3; Lipocalin-2; NGAL; Siderocalin LCN2; p25", "protein_names_refseq": "NGAL; alpha-2-microglobulin-related protein; alpha-2U globulin-related protein; lipocalin 2 (oncogene 24p3); lipocalin 24p3; neutrophil gelatinase-associated lipocalin precursor; neutrophil gelatinase-associated lipocalin; p25; siderocalin LCN2", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); urinary tract infection (Disease Ontology:DOID:0080784); traumatic brain injury (Disease Ontology:DOID:0081292); pre-eclampsia (Disease Ontology:DOID:10591); essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); uveitis (Disease Ontology:DOID:13141); acute cystitis (Disease Ontology:DOID:13148); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); hidradenitis suppurativa (Disease Ontology:DOID:2280); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); kidney disease (Disease Ontology:DOID:557); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); retinal degeneration (Disease Ontology:DOID:8466); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:170496); (R-RNO-6798695); (R-RNO-6799990); (R-RNO-917937)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "12453413;21538546;2462726;32845875;33319934;33510115;37672148;39265498", "class_list": "", "function": "Effect of Sleeve Gastrectomy on Glycometabolism via Forkhead Box O1 (FoxO1)/Lipocalin-2 (LCN2) Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (By similarity). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1/Nrf2/HO-1 pathway., [RefSeq, PubMed]; Silencing of lipocalin-2 improves cardiomyocyte viability under iron overload conditions via decreasing mitochondrial dysfunction and apoptosis., [RefSeq, PubMed]; The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2., [RefSeq, PubMed]; Upregulation of Megalin, Cubilin, NGAL mRNA expression in kidney may represent tubular injury and apoptosis in chronic condition of rat diabetic model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZF1", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:1903981 enterobactin binding;GO:0140315 iron ion sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0060205 cytoplasmic vesicle lumen", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0010628 positive regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30349-1", "uniprot_id": [ { "id": "LKHA4_RAT", "url": "https://www.uniprot.org/uniprot/P30349", "type": "external" } ], "mass": 69089.0, "length": 611, "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "Lta4h", "organism": "Rat", "refseq_name": "leukotriene A-4 hydrolase", "refseq_ac": [ { "id": "NP_001025202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025202", "type": "external" } ], "gene_names_uniprotkb": "Lta4h", "gene_names_refseq": "Lta4h", "protein_names_uniprotkb": "Leukotriene A-4 hydrolase; 3.3.2.6; 3.4.11.4; LTA-4 hydrolase; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H", "protein_names_refseq": "LTA-4 hydrolase; leukotriene A-4 hydrolase; tripeptide aminopeptidase LTA4H", "tax_id": 10116, "disease": "squamous cell carcinoma (Disease Ontology:DOID:1749); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (rno:299732); (R-RNO-2142691); (R-RNO-6798695); (R-RNO-9018676); (R-RNO-9018681); (R-RNO-9018896); (R-RNO-9020265); (R-RNO-9023661)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "1544505;24701582;30745237", "class_list": "", "function": "Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4), as well as other lipid epoxides. Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Gliotoxin suppresses the biosynthesis of the potent neutrophil chemoattractant LTB4 by direct interference with LTA4H thereby impairing neutrophil functions in invasive aspergillosis., [RefSeq, PubMed]; The involvement of compartmentalized and coupled changes of LTB4 and LTA4H in the resistance and development of arthritis in CIA model was demonstrated for the first time., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499P2", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0004301 epoxide hydrolase activity;GO:0070006 metalloaminopeptidase activity;GO:0004463 leukotriene-A4 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0010043 response to zinc ion;GO:0043171 peptide catabolic process;GO:0006691 leukotriene metabolic process;GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30349-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30951-1", "uniprot_id": [ { "id": "GPR12_RAT", "url": "https://www.uniprot.org/uniprot/P30951", "type": "external" } ], "mass": 36704.0, "length": 334, "protein_name": "G protein-coupled receptor 12", "gene_name": "Gpr12", "organism": "Rat", "refseq_name": "G-protein coupled receptor 12", "refseq_ac": [ { "id": "NP_001032372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032372", "type": "external" } ], "gene_names_uniprotkb": "Gpr12; Gpcr12", "gene_names_refseq": "Gpcr12; Gpr12", "protein_names_uniprotkb": "G protein-coupled receptor 12; R334", "protein_names_refseq": "G-protein coupled receptor 12; R334", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:80840)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16229830;17284443;1840531;21985983", "class_list": "", "function": "Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (PubMed:17284443). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production. Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation. Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12, [RefSeq, PubMed]; These findings indicate that GPR12 may play a role in neurite outgrowth during PC12 cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0JPJ1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32755-1", "uniprot_id": [ { "id": "HPPD_RAT", "url": "https://www.uniprot.org/uniprot/P32755", "type": "external" } ], "mass": 45112.0, "length": 393, "protein_name": "4-hydroxyphenylpyruvate dioxygenase", "gene_name": "Hpd", "organism": "Rat", "refseq_name": "4-hydroxyphenylpyruvate dioxygenase", "refseq_ac": [ { "id": "NP_058929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058929", "type": "external" } ], "gene_names_uniprotkb": "Hpd", "gene_names_refseq": "Hpd", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase; 1.13.11.27; 2.1.1.348; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; F Alloantigen; F protein; HPD; HPPDase; N(6)-adenosine-methyltransferase HPD", "protein_names_refseq": "4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPPDase; f Alloantigen; f protein", "tax_id": 10116, "disease": "tyrosinemia type III (Disease Ontology:DOID:0050727); hawkinsinuria (Disease Ontology:DOID:0111362)", "pathway": " (rno:29531); (R-RNO-8963684)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12867153;15301540;20677779;22673903;22872058;2445820;8814303", "class_list": "", "function": "Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Mutation in the rat (N241S) 4-hydroxyphenylpyruvate dioxygenase genes shows that the variant enzyme forms quinolacetic acid in place of the native product 2,5-dihydroxyphenylacetic acid., [RefSeq, PubMed]; Report utility of HPD for monitoring drug-induced liver injury in rat model., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88655", "ec_number_list": [ { "id": "2.1.1.348", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348", "type": "external" }, { "id": "1.13.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27", "type": "external" } ], "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P32755-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34058-1", "uniprot_id": [ { "id": "HS90B_RAT", "url": "https://www.uniprot.org/uniprot/P34058", "type": "external" } ], "mass": 83281.0, "length": 724, "protein_name": "Heat shock protein HSP 90-beta", "gene_name": "Hsp90ab1", "organism": "Rat", "refseq_name": "heat shock protein HSP 90-beta", "refseq_ac": [ { "id": "NP_001004082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004082", "type": "external" } ], "gene_names_uniprotkb": "Hsp90ab1; Hsp84; Hspc3; Hspcb", "gene_names_refseq": "HSP90-BETA; HSP90B; HSPC2; Hsp90ab1; Hspcb", "protein_names_uniprotkb": "Heat shock protein HSP 90-beta; HSP 84; HSP84; Heat shock 84 kDa", "protein_names_refseq": "HSP 84; HSP84; heat shock 84 kDa; heat shock 90kDa protein 1, beta; heat shock protein 90 alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein HSP 90-beta", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:301252); (R-RNO-168928); (R-RNO-2029482); (R-RNO-3371497); (R-RNO-3371511); (R-RNO-3371568); (R-RNO-3371571); (R-RNO-399954); (R-RNO-6798695); (R-RNO-844456); (R-RNO-8852276); (R-RNO-8937144); (R-RNO-8939211); (R-RNO-9013418); (R-RNO-9018519)", "pathway_count": 15, "publication_count": 10, "publication_id_list": "11732320;1525042;15808839;22673903;27496612;3189818;34502162;37975223;38843836;8663025", "class_list": "", "function": "HSP90beta regulates EAAT2 expression and participates in ischemia-reperfusion injury in rats., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1PSW2;Q66H55;Q68GV5;Q9QWC6", "ec_number_list": [], "go_molecular_function": "GO:0032564 dATP binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0061684 chaperone-mediated autophagy;GO:0043066 negative regulation of apoptotic process;GO:2000010 positive regulation of protein localization to cell surface;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P34058-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34064-1", "uniprot_id": [ { "id": "PSA5_RAT", "url": "https://www.uniprot.org/uniprot/P34064", "type": "external" } ], "mass": 26391.0, "length": 241, "protein_name": "Proteasome subunit alpha type-5", "gene_name": "Psma5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psma5", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome subunit alpha type-5; Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome subunit alpha-5; Proteasome zeta chain; alpha-5", "protein_names_refseq": "", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:29672); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 59, "publication_count": 2, "publication_id_list": "1491007;22673903", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P34064-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35332-1", "uniprot_id": [ { "id": "HPCL4_RAT", "url": "https://www.uniprot.org/uniprot/P35332", "type": "external" } ], "mass": 22245.0, "length": 191, "protein_name": "Hippocalcin-like protein 4", "gene_name": "Hpcal4", "organism": "Rat", "refseq_name": "hippocalcin-like protein 4", "refseq_ac": [ { "id": "NP_059053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059053", "type": "external" } ], "gene_names_uniprotkb": "Hpcal4", "gene_names_refseq": "Hpcal4; NVL-2; NVP-2; Nvjp2; VILIP-2", "protein_names_uniprotkb": "Hippocalcin-like protein 4; NVL-2; NVP-2; Neural visinin-like protein 2; VILIP-2; Visinin-like protein 2", "protein_names_refseq": "hippocalcin-like protein 4; neural visinin-like Ca2+-binding protein type 2; neural visinin-like protein 2; visinin-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:50872)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16049183;16049184;8360675", "class_list": "", "function": "Differential regulation of CaV2.1 channels by CaM, VILIP-2, CaBP1, and other neurospecific Ca2+-binding proteins is a potentially important determinant of Ca2+ entry in neurotransmission., [RefSeq, PubMed]; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation., [UniProtKB]; Nonmyristoylated CaBP1 and VILIP-2 bind to CaV2.1 channels and regulate them like CaM, whereas myristoylation allows differential, Ca2+-independent regulation by the inactive EF-hands of CaBP1 and VILIP-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35332-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35349-1", "uniprot_id": [ { "id": "GRM6_RAT", "url": "https://www.uniprot.org/uniprot/P35349", "type": "external" } ], "mass": 95089.0, "length": 871, "protein_name": "Metabotropic glutamate receptor 6", "gene_name": "Grm6", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 6 precursor", "refseq_ac": [ { "id": "NP_075209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075209", "type": "external" } ], "gene_names_uniprotkb": "Grm6; Gprc1f; Mglur6", "gene_names_refseq": "Grm6; mGluR6", "protein_names_uniprotkb": "Metabotropic glutamate receptor 6; mGluR6", "protein_names_refseq": "glutamate receptor, metabotropic 6; metabotropic glutamate receptor 6 precursor; metabotropic glutamate receptor 6", "tax_id": 10116, "disease": "congenital stationary night blindness 1B (Disease Ontology:DOID:0110865)", "pathway": " (rno:24419); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21832182;30739574;8389366", "class_list": "", "function": "Effects of mGluR6 overexpression were reversed by mGluR6 knockdown. In conclusion, mGluR6 promotes the proliferation of NSCs by activation of ERK1/2-Cyclin D1/CDK2 signaling pathway and inhibits the apoptosis of NSCs by blockage of the p38 MAPK signaling pathway, [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision., [UniProtKB, PubMed]; MGluR6 and TRPM1 are identified as nyctalopin binding partners; the postsynaptic accumulation of TRPM1 complex is dependent on mGluR6., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0042803 protein homodimerization activity;GO:0008066 glutamate receptor activity", "go_cellular_component": "GO:0035841 new growing cell tip;GO:0051286 cell tip;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0007268 chemical synaptic transmission;GO:0007416 synapse assembly;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35349-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35572-1", "uniprot_id": [ { "id": "IBP6_RAT", "url": "https://www.uniprot.org/uniprot/P35572", "type": "external" } ], "mass": 24193.0, "length": 226, "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "Igfbp6", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 6 precursor", "refseq_ac": [ { "id": "NP_037236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037236", "type": "external" } ], "gene_names_uniprotkb": "Igfbp6; Igfbp-6", "gene_names_refseq": "IGF-BP6; Igfbp6; RBP6A; RBP6G", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6", "protein_names_refseq": "IBP-6; IGF-binding protein 6; IGFBP-6; insulin-like growth factor-binding protein 6 precursor", "tax_id": 10116, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); primary ovarian insufficiency 2A (Disease Ontology:DOID:0080858); microcephaly (Disease Ontology:DOID:10907); leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); primary ovarian insufficiency (Disease Ontology:DOID:5426); in situ carcinoma (Disease Ontology:DOID:8719); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25641); (R-RNO-381426)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1709938;1719383;21598309;27888466;28044240;7682065", "class_list": "", "function": "Following spinal cord injury, IGFBP6 was significantly up-regulated., [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration., [UniProtKB, UniProtKB]; IGFBP-6 was significantly up-regulated adjacent to the hematoma following intracerebral hemorrhage., [RefSeq, PubMed]; IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499W1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042568 insulin-like growth factor binary complex", "go_biological_process": "GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35572-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35894-1", "uniprot_id": [ { "id": "GU01_RAT", "url": "https://www.uniprot.org/uniprot/P35894", "type": "external" } ], "mass": 20605.0, "length": 185, "protein_name": "Putative gustatory receptor PTE01", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative gustatory receptor PTE01", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8380780", "class_list": "", "function": "Possible taste receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35894-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36375-1", "uniprot_id": [ { "id": "KLK10_RAT", "url": "https://www.uniprot.org/uniprot/P36375", "type": "external" } ], "mass": 28981.0, "length": 259, "protein_name": "Glandular kallikrein-10", "gene_name": "Klk10", "organism": "Rat", "refseq_name": "glandular kallikrein-10 precursor", "refseq_ac": [ { "id": "NP_001128645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128645", "type": "external" } ], "gene_names_uniprotkb": "Klk10; Klk-10", "gene_names_refseq": "Klk10; Klk1c10; rGK-10", "protein_names_uniprotkb": "Glandular kallikrein-10; 3.4.21.35; Endopeptidase K; K10; Proteinase B; T-kininogenase; Tissue kallikrein; rGK-10", "protein_names_refseq": "K10; T-kininogenase; endopeptidase K; glandular kallikrein-10 precursor; glandular kallikrein-10-like; proteinase B antigen; tissue kallikrein", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); ovarian cancer (Disease Ontology:DOID:2394); uterine cancer (Disease Ontology:DOID:363)", "pathway": " (rno:292858)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1420203;2026164;2303430;3482210", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This protein may be involved in the regulation of renal function., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006508 proteolysis;GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0002803 positive regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P36375-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36376-1", "uniprot_id": [ { "id": "KLK12_RAT", "url": "https://www.uniprot.org/uniprot/P36376", "type": "external" } ], "mass": 28759.0, "length": 259, "protein_name": "Glandular kallikrein-12, submandibular/renal", "gene_name": "Klk12; Klk1c12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Klk12; Klk1c12; Klk-12", "gene_names_refseq": "", "protein_names_uniprotkb": "Glandular kallikrein-12, submandibular/renal; 3.4.21.35; RSKG-3; Tissue kallikrein", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:292855)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2849988", "class_list": "", "function": "Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0003073 regulation of systemic arterial blood pressure;GO:0031638 zymogen activation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36376-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36506-1", "uniprot_id": [ { "id": "MP2K2_RAT", "url": "https://www.uniprot.org/uniprot/P36506", "type": "external" } ], "mass": 44282.0, "length": 400, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 2", "gene_name": "Map2k2", "organism": "Rat", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 2", "refseq_ac": [ { "id": "NP_579817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579817", "type": "external" } ], "gene_names_uniprotkb": "Map2k2; Mek2; Mkk2; Prkmk2", "gene_names_refseq": "Map2k2; Prkmk2", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 2; 2.7.12.2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2", "protein_names_refseq": "ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; MEK2; dual specificity mitogen-activated protein kinase kinase 2", "tax_id": 10116, "disease": "RASopathy (Disease Ontology:DOID:0080690); cardiofaciocutaneous syndrome 4 (Disease Ontology:DOID:0111463); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); small intestine adenocarcinoma (Disease Ontology:DOID:4906); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:58960); (R-RNO-112411); (R-RNO-170968); (R-RNO-445144); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5674499)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "22673903;36642184;8393135;8462694", "class_list": "", "function": "Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JN15", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0048679 regulation of axon regeneration;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41137-1", "uniprot_id": [ { "id": "ID2_RAT", "url": "https://www.uniprot.org/uniprot/P41137", "type": "external" } ], "mass": 14989.0, "length": 134, "protein_name": "DNA-binding protein inhibitor ID-2", "gene_name": "Id2", "organism": "Rat", "refseq_name": "DNA-binding protein inhibitor ID-2", "refseq_ac": [ { "id": "NP_037192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037192", "type": "external" } ], "gene_names_uniprotkb": "Id2; Id-2", "gene_names_refseq": "Ac2-300; Id2", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-2; Inhibitor of DNA binding 2; Inhibitor of differentiation 2", "protein_names_refseq": "DNA-binding protein inhibitor ID-2; inhibitor of DNA binding 2, HLH protein; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of differentiation 2", "tax_id": 10116, "disease": "desmosterolosis (Disease Ontology:DOID:0070654); lipid metabolism disorder (Disease Ontology:DOID:3146)", "pathway": " (rno:25587)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11706002;22673903;26768262;27938661;30143582;31539631;33808082;7864897;7908517", "class_list": "", "function": "BMP-7/Smads-induced Id2 upregulation and Id2/Twist interaction was involved in attenuating diabetic renal tubulointerstitial fibrosis. Erratum:[Int J Biochem Cell Biol. 2019 Dec;117:105623. doi: 10.1016/j.biocel.2019.105623. PMID: 31630925], [RefSeq, PubMed]; Here, the authors discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S14) on Inhibitor of DNA binding 2 (Id2). Publication Status: Online-Only, [RefSeq, PubMed]; Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of Id2 alleviates neuropathic pain by inhibiting the NF-kappaB activation., [RefSeq, PubMed]; These data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0044325 transmembrane transporter binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0043353 enucleate erythrocyte differentiation;GO:0003166 bundle of His development;GO:0061031 endodermal digestive tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P41137-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41138-1", "uniprot_id": [ { "id": "ID3_RAT", "url": "https://www.uniprot.org/uniprot/P41138", "type": "external" } ], "mass": 13059.0, "length": 119, "protein_name": "DNA-binding protein inhibitor ID-3", "gene_name": "Id3", "organism": "Rat", "refseq_name": "DNA-binding protein inhibitor ID-3", "refseq_ac": [ { "id": "NP_037190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037190", "type": "external" } ], "gene_names_uniprotkb": "Id3; Id-3", "gene_names_refseq": "Id3", "protein_names_uniprotkb": "DNA-binding protein inhibitor ID-3; Inhibitor of DNA binding 3; Inhibitor of differentiation 3", "protein_names_refseq": "DNA-binding protein inhibitor ID-3; inhibitor of DNA binding 3, HLH protein; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; inhibitor of differentiation 3", "tax_id": 10116, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692)", "pathway": " (rno:25585)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19618124;24499487;7864897;7908517", "class_list": "", "function": "Relevant interaction of GKLF, Id3, and p53 for VSMC proliferation, [RefSeq, PubMed]; The function of GLCE in neuritogenesis via SMAD/ID3 signalling was studied via mutagenesis and gene silencing studies., [RefSeq, PubMed]; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901707 leptomycin B binding;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity;GO:0003714 transcription corepressor activity;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072750 cellular response to leptomycin B;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41138-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41562-1", "uniprot_id": [ { "id": "IDHC_RAT", "url": "https://www.uniprot.org/uniprot/P41562", "type": "external" } ], "mass": 46734.0, "length": 414, "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic", "gene_name": "Idh1", "organism": "Rat", "refseq_name": "isocitrate dehydrogenase [NADP] cytoplasmic", "refseq_ac": [ { "id": "NP_113698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113698", "type": "external" } ], "gene_names_uniprotkb": "Idh1", "gene_names_refseq": "IDPc; Idh1", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP] cytoplasmic; 1.1.1.42; Cytosolic NADP-isocitrate dehydrogenase; IDH1; IDH; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase", "protein_names_refseq": "IDH; IDP; Isocitrate dehydrogenase 1, soluble; NADP(+)-specific ICDH; cytosolic NADP-isocitrate dehydrogenase; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase [NADP] cytoplasmic; oxalosuccinate decarboxylase", "tax_id": 10116, "disease": "D-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050575); myelodysplastic syndrome (Disease Ontology:DOID:0050908); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); autoimmune disease (Disease Ontology:DOID:417); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:24479); (R-RNO-389542); (R-RNO-6798695); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10521434;33599048;38780519;7787968;8083215", "class_list": "", "function": "Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (By similarity). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human-derived glioblastoma cell lines., [RefSeq, PubMed]; Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P80300", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.3.2.36", "url": 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"https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0004450 isocitrate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41562-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42203-1", "uniprot_id": [ { "id": "IL13_RAT", "url": "https://www.uniprot.org/uniprot/P42203", "type": "external" } ], "mass": 14093.0, "length": 131, "protein_name": "Interleukin-13", "gene_name": "Il13", "organism": "Rat", "refseq_name": "interleukin-13 precursor", "refseq_ac": [ { "id": "NP_446280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446280", "type": "external" } ], "gene_names_uniprotkb": "Il13; Il-13", "gene_names_refseq": "Il13", "protein_names_uniprotkb": "Interleukin-13; IL-13; T-cell activation protein P600", "protein_names_refseq": "IL-13; T-cell activation protein P600; interleukin-13 precursor", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); lipoid nephrosis (Disease Ontology:DOID:10966); prostatic hypertrophy (Disease Ontology:DOID:11132); allergic conjunctivitis (Disease Ontology:DOID:11204); pulmonary edema (Disease Ontology:DOID:11396); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); peptic esophagitis (Disease Ontology:DOID:13976); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); multiple sclerosis (Disease Ontology:DOID:2377); dermatitis (Disease Ontology:DOID:2723); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); purpura (Disease Ontology:DOID:3326); mastocytosis (Disease Ontology:DOID:350); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); milk allergy (Disease Ontology:DOID:4376); egg allergy (Disease Ontology:DOID:4377); peanut allergy (Disease Ontology:DOID:4378); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); localized scleroderma (Disease Ontology:DOID:8472); lung disease (Disease Ontology:DOID:850); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:116553); (R-RNO-6785807)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "33801783;7916615;9366558", "class_list": "", "function": "Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:9366558). Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (PubMed:9366558). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Interleukin-13 Propagates Prothrombin Kringle-2-Induced Neurotoxicity in Hippocampi In Vivo via Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005144 interleukin-13 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:2000231 positive regulation of pancreatic stellate cell proliferation;GO:0043032 positive regulation of macrophage activation;GO:0010155 regulation of proton transport;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P42203-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42571-1", "uniprot_id": [ { "id": "PO2F3_RAT", "url": "https://www.uniprot.org/uniprot/P42571", "type": "external" } ], "mass": 46805.0, "length": 430, "protein_name": "POU domain, class 2, transcription factor 3", "gene_name": "Pou2f3", "organism": "Rat", "refseq_name": "POU domain, class 2, transcription factor 3", "refseq_ac": [ { "id": "NP_001099215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099215", "type": "external" } ], "gene_names_uniprotkb": "Pou2f3; Otf11; Skn-1; Skn1", "gene_names_refseq": "Pou2f3", "protein_names_uniprotkb": "POU domain, class 2, transcription factor 3; OTF-11; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; Transcription factor Skn-1", "protein_names_refseq": "OTF-11; POU domain, class 2, transcription factor 3; Rov 1 pou-homeodomain protein; oct-11; octamer-binding protein 11; octamer-binding transcription factor 11; transcription factor Skn-1", "tax_id": 10116, "disease": "immune system disease (Disease Ontology:DOID:2914)", "pathway": " (rno:116544)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7682011", "class_list": "", "function": "Inhibits transactivation by POU2F1., [UniProtKB, PubMed]; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:7682011). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6A0U7;P42572", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43118-1", "uniprot_id": [ { "id": "PF2R_RAT", "url": "https://www.uniprot.org/uniprot/P43118", "type": "external" } ], "mass": 40655.0, "length": 366, "protein_name": "Prostaglandin F2-alpha receptor", "gene_name": "Ptgfr", "organism": "Rat", "refseq_name": "prostaglandin F2-alpha receptor", "refseq_ac": [ { "id": "NP_037247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037247", "type": "external" } ], "gene_names_uniprotkb": "Ptgfr", "gene_names_refseq": "PF2AR; Ptgfr", "protein_names_uniprotkb": "Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor", "protein_names_refseq": "PGF receptor; PGF2-alpha receptor; prostaglandin F2-alpha receptor; prostanoid FP receptor", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); XFE progeroid syndrome (Disease Ontology:DOID:0060590); xeroderma pigmentosum group A (Disease Ontology:DOID:0110843); xeroderma pigmentosum group F (Disease Ontology:DOID:0110848); Fanconi anemia complementation group Q (Disease Ontology:DOID:0111093); Fanconi anemia (Disease Ontology:DOID:13636); polyneuropathy due to drug (Disease Ontology:DOID:14184); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); Cockayne syndrome (Disease Ontology:DOID:2962); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25652); (R-RNO-391908); (R-RNO-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "18703136;19429887;24136214;25341845;7972878;7988697;8804121;8912810", "class_list": "", "function": "Activity of PGF(2alpha) by putative pacemaker cells underlies the generation of calcium action potentials in normal rat kidney monolayers., [RefSeq, PubMed]; Data found that FP localizes in neuronal somata and dendrites but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I., [RefSeq, PubMed]; Prostaglandin F-receptor antagonist AS604872 exacerbates vascular inflammation in hypertensive animals, facilitating intracranial aneurysm formation and aortic dissection., [RefSeq, PubMed]; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum., [UniProtKB]; There was an increase rat prostaglandin F receptor expression in rat uterus with advancing gestation, a marked elevation of expression at term, and a concominant decrease during the postpartum period., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62787", "ec_number_list": [], "go_molecular_function": "GO:0004958 prostaglandin F receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43118-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45479-1", "uniprot_id": [ { "id": "PPT1_RAT", "url": "https://www.uniprot.org/uniprot/P45479", "type": "external" } ], "mass": 34455.0, "length": 306, "protein_name": "Palmitoyl-protein thioesterase 1", "gene_name": "Ppt1", "organism": "Rat", "refseq_name": "palmitoyl-protein thioesterase 1 precursor", "refseq_ac": [ { "id": "NP_071947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071947", "type": "external" } ], "gene_names_uniprotkb": "Ppt1; Cln1; Ppt", "gene_names_refseq": "Ppt1; Ppt", "protein_names_uniprotkb": "Palmitoyl-protein thioesterase 1; 3.1.2.22; 3.1.2.2; PPT-1; Palmitoyl-protein hydrolase 1", "protein_names_refseq": "PPT-1; palmitoyl-protein hydrolase 1; palmitoyl-protein thioesterase 1 precursor", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 1 (Disease Ontology:DOID:0110721); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:29411); (R-RNO-75105)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1039/D0MO00044B;24302477;34106099;7916016", "class_list": "", "function": "Has thioesterase activity against fatty acid thioesters with 14-18 carbons, including palmitoyl-CoA, S-palmitoyl-N-acetylcysteamine, and palmitoylated proteins. In contrast to PPT2, PPT1 can hydrolyze palmitoylated proteins and palmitoylcysteine., [UniProtKB, UniProtKB]; PPT1 expression may provide a testicular marker of reduced fertility in obese males, as increases in its expression may be detrimental to Sertoli-cell function during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0JN20", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0019834 phospholipase A2 inhibitor activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0035727 lysophosphatidic acid binding;GO:0120146 sulfatide binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0031579 membrane raft organization;GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0008306 associative learning;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P45479-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46090-1", "uniprot_id": [ { "id": "CML2_RAT", "url": "https://www.uniprot.org/uniprot/P46090", "type": "external" } ], "mass": 40887.0, "length": 353, "protein_name": "Chemerin-like receptor 2", "gene_name": "Cmklr2", "organism": "Rat", "refseq_name": "chemerin-like receptor 2", "refseq_ac": [ { "id": "NP_037093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037093", "type": "external" } ], "gene_names_uniprotkb": "Cmklr2; Gpr1", "gene_names_refseq": "Cmklr2; Gpr1", "protein_names_uniprotkb": "Chemerin-like receptor 2; Chemerin chemokine-like receptor 2; Chemokine-like receptor 2; G protein-coupled receptor 1", "protein_names_refseq": "G protein-coupled receptor 1; G-protein copled receptor 1; chemerin-like receptor 2; chemokine-like receptor 2; probable G-protein coupled receptor 1", "tax_id": 10116, "disease": "congenital disorder of glycosylation Ir (Disease Ontology:DOID:0080569)", "pathway": " (rno:25457)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27742615;7811287", "class_list": "", "function": "CMKLR1 and GPR1 were widely expressed in vascular smooth muscle. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (By similarity). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M0RCK7", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding;GO:0097003 adipokinetic hormone receptor activity;GO:0097004 adipokinetic hormone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0097648 G protein-coupled receptor complex", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47816-1", "uniprot_id": [ { "id": "PDCD2_RAT", "url": "https://www.uniprot.org/uniprot/P47816", "type": "external" } ], "mass": 38444.0, "length": 343, "protein_name": "uS5 assembly chaperone PDCD2", "gene_name": "Pdcd2", "organism": "Rat", "refseq_name": "uS5 assembly chaperone PDCD2", "refseq_ac": [ { "id": "NP_113826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113826", "type": "external" } ], "gene_names_uniprotkb": "Pdcd2; Rp8", "gene_names_refseq": "Pdcd2", "protein_names_uniprotkb": "uS5 assembly chaperone PDCD2; Programmed cell death protein 2; Zinc finger protein Rp-8", "protein_names_refseq": "programmed cell death protein 2; uS5 assembly chaperone PDCD2; zinc finger protein Rp-8", "tax_id": 10116, "disease": "", "pathway": " (rno:58934)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2072913", "class_list": "", "function": "Chaperone for ribosomal protein uS5; cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the nucleus; appears to function redundantly to PDCD2L., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V666", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:0012501 programmed cell death;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P47816-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47824-1", "uniprot_id": [ { "id": "P2RX1_RAT", "url": "https://www.uniprot.org/uniprot/P47824", "type": "external" } ], "mass": 44957.0, "length": 399, "protein_name": "P2X purinoceptor 1", "gene_name": "P2rx1", "organism": "Rat", "refseq_name": "P2X purinoceptor 1 isoform 2", "refseq_ac": [ { "id": "NP_001135839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135839", "type": "external" } ], "gene_names_uniprotkb": "P2rx1", "gene_names_refseq": "P2XMR; P2rx1", "protein_names_uniprotkb": "P2X purinoceptor 1; ATP receptor; P2X1; Purinergic receptor; RP-2 protein", "protein_names_refseq": "ATP receptor; P2X purinoceptor 1 isoform 2; P2X purinoceptor 1; P2X1; RP-2 protein; purinergic receptor P2X, ligand-gated ion channel, 1", "tax_id": 10116, "disease": "", "pathway": " (rno:25505); (R-RNO-139853); (R-RNO-418346); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10942758;15313628;15686495;2072913;25680470;26481522;27442785;28404593;7523951;9606184;9855626", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:15686495, PubMed:7523951, PubMed:9606184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Indicate a predominant role for P2X1R and P2X7R in the control of glomerular hemodynamics in ANG II hypertension., [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB]; Study demonstrated that P2X1 receptor-mediated calcium ion influx triggered by DA-9801 potentiated the Nerve Growth Factor-induced neurite outgrowth. The results obtained in this study imply a possible relationship between P2X1 and neuroregeneration., [RefSeq, PubMed]; The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp., [RefSeq, PubMed]; Work identified that in major arteries of rat cerebral circulation Vascular Smooth Muscle Cells express only P2X1 and P2X4 receptors subunits., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0044877 protein-containing complex binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0002554 serotonin secretion by platelet;GO:0007320 insemination;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0006811 monoatomic ion transport;GO:0006940 regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P47824-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48998-1", "uniprot_id": [ { "id": "INVO_RAT", "url": "https://www.uniprot.org/uniprot/P48998", "type": "external" } ], "mass": 67021.0, "length": 568, "protein_name": "Involucrin", "gene_name": "Ivl", "organism": "Rat", "refseq_name": "involucrin", "refseq_ac": [ { "id": "NP_071531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071531", "type": "external" } ], "gene_names_uniprotkb": "Ivl", "gene_names_refseq": "Ivl", "protein_names_uniprotkb": "Involucrin", "protein_names_refseq": "involucrin", "tax_id": 10116, "disease": "", "pathway": " (rno:60583)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18648826;21744336;22673903;8277848", "class_list": "", "function": "Expression in outer root sheath cells of hair follicles is upregulated by Epidermal Growth Factor, [RefSeq, PubMed]; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The level of mRNA for differentiation markers: involucrin, filaggrin, keratinocyte differentiation associated protein and trichohyalin, was studied by RealTime PCR., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization;GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0010224 response to UV-B;GO:0002786 regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48998-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49654-1", "uniprot_id": [ { "id": "P2RX3_RAT", "url": "https://www.uniprot.org/uniprot/P49654", "type": "external" } ], "mass": 44392.0, "length": 397, "protein_name": "P2X purinoceptor 3", "gene_name": "P2rx3", "organism": "Rat", "refseq_name": "P2X purinoceptor 3 isoform 2", "refseq_ac": [ { "id": "NP_001257550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257550", "type": "external" } ], "gene_names_uniprotkb": "P2rx3", "gene_names_refseq": "P2rx3", "protein_names_uniprotkb": "P2X purinoceptor 3; ATP receptor; P2X3; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 3 isoform 2; P2X purinoceptor 3; P2X3; purinergic receptor P2X, ligand-gated ion channel, 3", "tax_id": 10116, "disease": "", "pathway": " (rno:81739); (R-RNO-139853); (R-RNO-418346)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10440098;11181939;33902429;34622458;36397224;36633528;37656312;7566119;7566120;9721930", "class_list": "", "function": "Estrogen inhibits bladder overactivity in rats with cyclophosphamide-induced cystitis via downregulating the expression of P2X3 receptors in bladder epithelium cells., [RefSeq, PubMed]; Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:7566119, PubMed:7566120). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Extracellular ATP-activated non-selective cation channel. Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization., [UniProtKB, UniProtKB, UniProtKB]; HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation., [RefSeq, PubMed]; MiR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats., [RefSeq, PubMed]; P2X3 receptor upregulation in trigeminal ganglion neurons through TNFalpha production in macrophages contributes to trigeminal neuropathic pain in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [Effect of electroacupuncture on the expressions of TRPV1, P2X3 receptors in bladder of rats with interstitial cystitis]., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043197 dendritic spine", "go_biological_process": "GO:0030432 peristalsis;GO:0061368 behavioral response to formalin induced pain;GO:0006811 monoatomic ion transport;GO:0007274 neuromuscular synaptic transmission;GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P49654-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49655-1", "uniprot_id": [ { "id": "KCJ10_RAT", "url": "https://www.uniprot.org/uniprot/P49655", "type": "external" } ], "mass": 42480.0, "length": 379, "protein_name": "ATP-sensitive inward rectifier potassium channel 10", "gene_name": "Kcnj10", "organism": "Rat", "refseq_name": "ATP-sensitive inward rectifier potassium channel 10", "refseq_ac": [ { "id": "NP_113790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113790", "type": "external" } ], "gene_names_uniprotkb": "Kcnj10; Kab-2", "gene_names_refseq": "Kcnj10", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; Brain-specific inwardly rectifying K(+) channel 1; Inward rectifier K(+) channel Kir4.1; Potassium channel, inwardly rectifying subfamily J member 10", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; brain-specific inwardly rectifying K(+) channel 1; inward rectifier K(+) channel Kir4.1; kir4.1; potassium channel, inwardly rectifying subfamily J member 10; potassium voltage-gated channel subfamily J member 10", "tax_id": 10116, "disease": "EAST syndrome (Disease Ontology:DOID:0060484); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); sensorineural hearing loss (Disease Ontology:DOID:10003); uveitis (Disease Ontology:DOID:13141); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); reflex epilepsy (Disease Ontology:DOID:2548); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725); retinal degeneration (Disease Ontology:DOID:8466); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:29718); (R-RNO-1296041); (R-RNO-1296067); (R-RNO-997272)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "18690035;20807765;29474462;30813600;33161102;34510584;35583060;38355723;7608203;7624316;7874445", "class_list": "", "function": "Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines., [RefSeq, PubMed]; Dysfunction of oligodendrocyte inwardly rectifying potassium channel in a rat model of amyotrophic lateral sclerosis., [RefSeq, PubMed]; He down-regulation of Kir4.1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation. Publication Status: Online-Only, [RefSeq, PubMed]; May be responsible for potassium buffering action of glial cells in the brain (PubMed:7608203). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:7608203). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity)., [UniProtKB, UniProtKB, PubMed]; Studies suggest that AGE-modification of laminin is detrimental to Kir4.1 channels. By studying the role of AGEs in Kir4.1 channels we have identified a novel mechanism of Muller cell dysfunction and its subsequent involvement in Diabetic retinopathy. Publication Status: Online-Only, [RefSeq, PubMed]; [IL-6 promotes the activation of rat astrocytes and down-regulation of the expression of Kir4.1 channel]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62790", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0097449 astrocyte projection;GO:0016324 apical plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:0022010 central nervous system myelination;GO:0042391 regulation of membrane potential;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0051384 response to glucocorticoid;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49655-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51639-1", "uniprot_id": [ { "id": "HMDH_RAT", "url": "https://www.uniprot.org/uniprot/P51639", "type": "external" } ], "mass": 96688.0, "length": 887, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "gene_name": "Hmgcr", "organism": "Rat", "refseq_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "refseq_ac": [ { "id": "NP_037266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037266", "type": "external" } ], "gene_names_uniprotkb": "Hmgcr", "gene_names_refseq": "3H3M; Hmgcr", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase; 1.1.1.34; HMG-CoA reductase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25675); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1628744;2369897;28938515;29393594;33412161;34081950;4019513", "class_list": "", "function": "A-family anti-inflammatory cyclopentenone prostaglandins: A novel class of non-statin inhibitors of HMG-CoA reductase., [RefSeq, PubMed]; An evolutionarily-conserved promoter allele governs HMG-CoA reductase expression in spontaneously hypertensive rat., [RefSeq, PubMed]; Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study is aiming to investigate the inhibition role of quercetin on hydroxy methyl glutarate - CoA reductase activity and its gene for attenuating hypercholesterolemia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64601;Q6P2A6", "ec_number_list": [ { "id": "1.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0042802 identical protein binding;GO:0051721 protein phosphatase 2A binding;GO:0030695 GTPase regulator activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0007584 response to nutrient;GO:0008284 positive regulation of cell population proliferation;GO:0008542 visual learning;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51639-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51651-1", "uniprot_id": [ { "id": "GPR6_RAT", "url": "https://www.uniprot.org/uniprot/P51651", "type": "external" } ], "mass": 38115.0, "length": 363, "protein_name": "G protein-coupled receptor 6", "gene_name": "Gpr6", "organism": "Rat", "refseq_name": "G-protein coupled receptor 6", "refseq_ac": [ { "id": "NP_113994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113994", "type": "external" } ], "gene_names_uniprotkb": "Gpr6; Cnl3", "gene_names_refseq": "Gpr6", "protein_names_uniprotkb": "G protein-coupled receptor 6; Sphingosine 1-phosphate receptor GPR6", "protein_names_refseq": "G-protein coupled receptor 6; putative G protein-coupled receptor (CNL3); sphingosine 1-phosphate receptor GPR6", "tax_id": 10116, "disease": "", "pathway": " (rno:83683)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11169503;17284443;19059244;23150673;30376752;8082799", "class_list": "", "function": "C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity, [RefSeq, PubMed]; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons., [UniProtKB, PubMed]; Pharmacological evidence of this receptor was found in the brains of mammals and pigeon, but not frog or newt. Bioinfomatics results implicate GPR6 as a possible candidate for the additional WIN55212-2-sensitive receptor., [RefSeq, PubMed]; The localization of GPR6 in HEK293 cells and striatal neurons was assessed., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51651-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51653-1", "uniprot_id": [ { "id": "GPC2_RAT", "url": "https://www.uniprot.org/uniprot/P51653", "type": "external" } ], "mass": 63354.0, "length": 579, "protein_name": "Glypican-2", "gene_name": "Gpc2", "organism": "Rat", "refseq_name": "glypican-2 precursor", "refseq_ac": [ { "id": "NP_612520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612520", "type": "external" } ], "gene_names_uniprotkb": "Gpc2", "gene_names_refseq": "Gpc2", "protein_names_uniprotkb": "Glypican-2; Cerebroglycan; HSPG M13", "protein_names_refseq": "HSPG M13; cerebroglycan; glypican-2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:171517); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12084985;27671118;8294498", "class_list": "", "function": "Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0016477 cell migration;GO:0030182 neuron differentiation;GO:0009966 regulation of signal transduction;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51653-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52188-1", "uniprot_id": [ { "id": "KCJ12_RAT", "url": "https://www.uniprot.org/uniprot/P52188", "type": "external" } ], "mass": 48399.0, "length": 427, "protein_name": "ATP-sensitive inward rectifier potassium channel 12", "gene_name": "Kcnj12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnj12; Irk2", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 12; IRK-2; Inward rectifier K(+) channel Kir2.2; Potassium channel, inwardly rectifying subfamily J member 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "EAST syndrome (Disease Ontology:DOID:0060484)", "pathway": " (R-RNO-1296041); (R-RNO-1296053); (R-RNO-5576886); (R-RNO-997272)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "14960569;21209095;8137958", "class_list": "", "function": "Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells (By similarity). It probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030165 PDZ domain binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0030315 T-tubule", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52188-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52191-1", "uniprot_id": [ { "id": "KCJ16_RAT", "url": "https://www.uniprot.org/uniprot/P52191", "type": "external" } ], "mass": 47936.0, "length": 419, "protein_name": "Inward rectifier potassium channel 16", "gene_name": "Kcnj16", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnj16", "gene_names_refseq": "", "protein_names_uniprotkb": "Inward rectifier potassium channel 16; BIR9; Inward rectifier K(+) channel Kir5.1; Potassium channel, inwardly rectifying subfamily J member 16", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); EAST syndrome (Disease Ontology:DOID:0060484); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (rno:29719); (R-RNO-1296041); (R-RNO-1296067); (R-RNO-997272)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10764726;18690035;20807765;7874445", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance (By similarity). In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI87", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane;GO:0006885 regulation of pH;GO:0071805 potassium ion transmembrane transport;GO:0010037 response to carbon dioxide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P52191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52925-1", "uniprot_id": [ { "id": "HMGB2_RAT", "url": "https://www.uniprot.org/uniprot/P52925", "type": "external" } ], "mass": 24159.0, "length": 210, "protein_name": "High mobility group protein B2", "gene_name": "Hmgb2", "organism": "Rat", "refseq_name": "high mobility group box 2-like 1", "refseq_ac": [ { "id": "NP_001316810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316810", "type": "external" } ], "gene_names_uniprotkb": "Hmgb2; Hmg2", "gene_names_refseq": "HMG2; Hmgb2l1; RGD1564519", "protein_names_uniprotkb": "High mobility group protein B2; HMG-2; High mobility group protein 2", "protein_names_refseq": "high mobility group box 2-like 1; high mobility group protein B2", "tax_id": 10116, "disease": "", "pathway": " (rno:29395); (rno:498072); (R-RNO-140342)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity. Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVP0", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0050786 RAGE receptor binding;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P52925-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52947-1", "uniprot_id": [ { "id": "PDX1_RAT", "url": "https://www.uniprot.org/uniprot/P52947", "type": "external" } ], "mass": 30831.0, "length": 283, "protein_name": "Pancreas/duodenum homeobox protein 1", "gene_name": "Pdx1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdx1; Ipf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreas/duodenum homeobox protein 1; IDX-1; IPF-1; Insulin promoter factor 1; Islet/duodenum homeobox 1; STF-1; Somatostatin-transactivating factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); pancreatic agenesis 1 (Disease Ontology:DOID:0061003); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); maturity-onset diabetes of the young type 4 (Disease Ontology:DOID:0111103); cerebral infarction (Disease Ontology:DOID:3526); placental insufficiency (Disease Ontology:DOID:3891); hyperglycemia (Disease Ontology:DOID:4195); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29535)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17095531;22673903;7505393;7907546", "class_list": "", "function": "Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0044877 protein-containing complex binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043279 response to alkaloid;GO:0010157 response to chlorate;GO:0033273 response to vitamin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52947-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52949-1", "uniprot_id": [ { "id": "HXA5_RAT", "url": "https://www.uniprot.org/uniprot/P52949", "type": "external" } ], "mass": 25391.0, "length": 233, "protein_name": "Homeobox protein Hox-A5", "gene_name": "Hoxa5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hoxa5; Hox-1.3; Hoxa-5; LOC103692127", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-A5; Homeobox protein Hox-1.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:79241)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7915120", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030878 thyroid gland development;GO:0060574 intestinal epithelial cell maturation;GO:0060435 bronchiole development;GO:0060535 trachea cartilage morphogenesis;GO:0060638 mesenchymal-epithelial cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52949-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55063-1", "uniprot_id": [ { "id": "HS71L_RAT", "url": "https://www.uniprot.org/uniprot/P55063", "type": "external" } ], "mass": 70549.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1-like", "gene_name": "Hspa1l", "organism": "Rat", "refseq_name": "heat shock 70 kDa protein 1-like", "refseq_ac": [ { "id": "NP_997711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997711", "type": "external" } ], "gene_names_uniprotkb": "Hspa1l; Hsp70-3", "gene_names_refseq": "Hsp70-3; Hspa1l", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1-like; HSP70.3; Heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 3", "protein_names_refseq": "HSP70.3; Heat shock protein 70-1l; heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70 kDa protein 3; heat shock protein 1-like; heat shock protein 70", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); pneumoconiosis (Disease Ontology:DOID:10316); uveitis (Disease Ontology:DOID:13141); Kawasaki disease (Disease Ontology:DOID:13378); major depressive disorder (Disease Ontology:DOID:1470); schizophrenia (Disease Ontology:DOID:5419); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:24963); (R-RNO-3371453); (R-RNO-3371497); (R-RNO-3371568); (R-RNO-3371571); (R-RNO-9833482)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "15060004;15240697;7927536", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32P36;Q6MG67", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P55063-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55159-1", "uniprot_id": [ { "id": "PON1_RAT", "url": "https://www.uniprot.org/uniprot/P55159", "type": "external" } ], "mass": 39358.0, "length": 355, "protein_name": "Serum paraoxonase/arylesterase 1", "gene_name": "Pon1", "organism": "Rat", "refseq_name": "serum paraoxonase/arylesterase 1", "refseq_ac": [ { "id": "NP_114466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114466", "type": "external" } ], "gene_names_uniprotkb": "Pon1; Pon", "gene_names_refseq": "Pon1", "protein_names_uniprotkb": "Serum paraoxonase/arylesterase 1; 3.1.1.2; 3.1.1.81; 3.1.8.1; A-esterase 1; Aromatic esterase 1; PON 1; Serum aryldialkylphosphatase 1", "protein_names_refseq": "A-esterase 1; PON 1; aromatic esterase 1; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1", "tax_id": 10116, "disease": "vitamin B12 deficiency (Disease Ontology:DOID:0050731); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); cerebral cavernous malformation (Disease Ontology:DOID:0060669); bone disease (Disease Ontology:DOID:0080001); beta-thalassemia major (Disease Ontology:DOID:0080771); keratoconus (Disease Ontology:DOID:10126); prostate cancer (Disease Ontology:DOID:10283); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); glucose intolerance (Disease Ontology:DOID:10603); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); diabetic angiopathy (Disease Ontology:DOID:11713); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); Behcet's disease (Disease Ontology:DOID:13241); exfoliation syndrome (Disease Ontology:DOID:13641); capillary leak syndrome (Disease Ontology:DOID:14400); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); atherosclerosis (Disease Ontology:DOID:1936); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:84024); (R-RNO-2142688); (R-RNO-9754706)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21454685;30946296;35589918;37647369;9032442", "class_list": "", "function": "BRAP silencing protects against neuronal inflammation, oxidative stress and apoptosis in cerebral ischemia-reperfusion injury by promoting PON1 expression., [RefSeq, PubMed]; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification., [UniProtKB, UniProtKB]; Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo., [RefSeq, PubMed]; Study indicates that low PON1 expression is predictive of severe IVDD; PON1 plays an important role of keeping the homeostatic balance of intervertebral discs., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 48, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08682;Q5BJN6", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.81", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle;GO:0034366 spherical high-density lipoprotein particle;GO:0005576 extracellular region", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0046434 organophosphate catabolic process;GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P55159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55770-1", "uniprot_id": [ { "id": "NH2L1_RAT", "url": "https://www.uniprot.org/uniprot/P55770", "type": "external" } ], "mass": 14174.0, "length": 128, "protein_name": "NHP2-like protein 1", "gene_name": "Snu13-ps5; Snu13", "organism": "Rat", "refseq_name": "NHP2-like protein 1", "refseq_ac": [ { "id": "NP_997680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997680", "type": "external" } ], "gene_names_uniprotkb": "Snu13-ps5; Snu13; Nhp2l1; Snu13", "gene_names_refseq": "Nhp2l1; Otk27; Snu13", "protein_names_uniprotkb": "NHP2-like protein 1; High mobility group-like nuclear protein 2 homolog 1; OTK27; U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein", "protein_names_refseq": "NHP2-like protein 1; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5); U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein; U4/U6.U5] tri-snRNP 15.5 kDa protein; high mobility group-like nuclear protein 2 homolog 1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:300092); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7667285", "class_list": "", "function": "Common component of the spliceosome and rRNA processing machinery., [UniProtKB, UniProtKB]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDV0", "ec_number_list": [], "go_molecular_function": "GO:0030621 U4 snRNA binding;GO:0003723 RNA binding;GO:0051117 ATPase binding;GO:0030622 U4atac snRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0032991 protein-containing complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0007338 single fertilization;GO:0000398 mRNA splicing, via spliceosome;GO:0000492 box C/D snoRNP assembly;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55770-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56223-1", "uniprot_id": [ { "id": "PO6F1_RAT", "url": "https://www.uniprot.org/uniprot/P56223", "type": "external" } ], "mass": 32702.0, "length": 301, "protein_name": "POU domain, class 6, transcription factor 1", "gene_name": "Pou6f1", "organism": "Rat", "refseq_name": "POU domain, class 6, transcription factor 1 isoform X5", "refseq_ac": [ { "id": "XP_017450058", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450058", "type": "external" } ], "gene_names_uniprotkb": "Pou6f1; Brn5", "gene_names_refseq": "Brn5; Pou6f1", "protein_names_uniprotkb": "POU domain, class 6, transcription factor 1; Brain-5; Brain-specific homeobox/POU domain protein 5; Brn-5", "protein_names_refseq": "POU domain, class 6, transcription factor 1 isoform X5", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:116545)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7901208", "class_list": "", "function": "Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3')., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56223-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58522-1", "uniprot_id": [ { "id": "NEPH_RAT", "url": "https://www.uniprot.org/uniprot/P58522", "type": "external" } ], "mass": 1983.0, "length": 21, "protein_name": "Nephritogenoside", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Nephritogenoside", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3410849", "class_list": "", "function": "Can induce glomerulonephritis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58522-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59035-1", "uniprot_id": [ { "id": "LRRC3_RAT", "url": "https://www.uniprot.org/uniprot/P59035", "type": "external" } ], "mass": 28146.0, "length": 257, "protein_name": "Leucine-rich repeat-containing protein 3", "gene_name": "Lrrc3", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_663712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663712", "type": "external" } ], "gene_names_uniprotkb": "Lrrc3", "gene_names_refseq": "Lrrc3", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 3", "protein_names_refseq": "leucine-rich repeat-containing protein 3 precursor; leucine-rich repeat-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:246773)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P59035-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60572-1", "uniprot_id": [ { "id": "PANX3_RAT", "url": "https://www.uniprot.org/uniprot/P60572", "type": "external" } ], "mass": 44978.0, "length": 392, "protein_name": "Pannexin-3", "gene_name": "Panx3", "organism": "Rat", "refseq_name": "pannexin-3", "refseq_ac": [ { "id": "NP_955430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955430", "type": "external" } ], "gene_names_uniprotkb": "Panx3; Px3", "gene_names_refseq": "Panx3", "protein_names_uniprotkb": "Pannexin-3", "protein_names_refseq": "pannexin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:315567)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14597722;19009624;20086016;20332104;21337450;21467198;37021698", "class_list": "", "function": "Although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules, [RefSeq, PubMed]; In the testis, Panx1 localized to the basal compartment of the seminiferous epithelium, while Panx3 was expressed in Leydig cells. In the ED, both Panxs were expressed in the apical region of ciliated cells., [RefSeq, PubMed]; Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis., [RefSeq, PubMed]; Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation., [RefSeq, PubMed]; Pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3., [RefSeq, PubMed]; Regulator of osteoblast differentiation by functioning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors., [UniProtKB, UniProtKB]; Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions. Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in article text], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005198 structural molecule activity;GO:0055077 gap junction hemi-channel activity;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006812 monoatomic cation transport;GO:0001649 osteoblast differentiation;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P60572-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60895-1", "uniprot_id": [ { "id": "GPR85_RAT", "url": "https://www.uniprot.org/uniprot/P60895", "type": "external" } ], "mass": 41995.0, "length": 370, "protein_name": "Probable G protein-coupled receptor 85", "gene_name": "Gpr85", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 85", "refseq_ac": [ { "id": "NP_071590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071590", "type": "external" } ], "gene_names_uniprotkb": "Gpr85; Sreb2", "gene_names_refseq": "Gpr85; PKrCx1; SREB2; Srep2", "protein_names_uniprotkb": "Probable G protein-coupled receptor 85; PKrCx1; Super conserved receptor expressed in brain 2", "protein_names_refseq": "Super Conserved Receptor Expressed in Brain 2; probable G-protein coupled receptor 85", "tax_id": 10116, "disease": "", "pathway": " (rno:64020)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10833454;15893849", "class_list": "", "function": "Orphan receptor., [UniProtKB]; The areas expressing high levels of SREB2 mRNA overlap with brain structures known to possess high levels of plasticity, namely, the hippocampal formation, olfactory system, and supraoptic and paraventricular nuclei., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHI6;Q9NPD1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60895-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61980-1", "uniprot_id": [ { "id": "HNRPK_RAT", "url": "https://www.uniprot.org/uniprot/P61980", "type": "external" } ], "mass": 50976.0, "length": 463, "protein_name": "Heterogeneous nuclear ribonucleoprotein K", "gene_name": "Hnrnpk; LOC100359916", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein K isoform 1", "refseq_ac": [ { "id": "NP_476482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476482", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpk; LOC100359916; Hnrpk; LOC100359916", "gene_names_refseq": "Csbp; Hnrnpk; Hnrpk", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein K; CSBP; dC stretch-binding protein; hnRNP K", "protein_names_refseq": "dC stretch-binding protein; heterogeneous nuclear ribonucleoprotein K isoform 1; hnRNP K", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Raynaud disease (Disease Ontology:DOID:10300); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:100359916); (rno:117282); (R-RNO-4570464); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "18683930;19170760;22673903;29255796;30450874;33576715;38843836;8127654", "class_list": "", "function": "Mitochondrial uncoupling protein 2 is regulated through heterogeneous nuclear ribonucleoprotein K in lead exposure models., [RefSeq, PubMed]; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results show that synaptic activity and BDNF regulate hnRNP K and hnRNP K-bound mRNAs in vitro and in vivo. The large number of transcripts showing a decreased coimmunoprecipitation with hnRNP K on stimulation with BDNF suggests a role for this RNP in the regulation of neuronal function in general and, in particular, in the BDNF-mediated plasticity events. Publication Status: Online-Only, [RefSeq, PubMed]; Results showed that hnRNP K was widely distributed in gonocytes, spermatogonia, sertoli cells and Leydig cells. The dynamic expression profile of hnRNP K may imply its crucial and potential roles in the development of the testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q07244;Q15671;Q60577;Q922Y7;Q96J62", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005938 cell cortex", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0072752 cellular response to rapamycin;GO:0033120 positive regulation of RNA splicing;GO:0060816 random inactivation of X chromosome;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61980-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62193-1", "uniprot_id": [ { "id": "PRS4_RAT", "url": "https://www.uniprot.org/uniprot/P62193", "type": "external" } ], "mass": 49185.0, "length": 440, "protein_name": "26S proteasome regulatory subunit 4", "gene_name": "Psmc1", "organism": "Rat", "refseq_name": "26S proteasome regulatory subunit 4", "refseq_ac": [ { "id": "NP_476464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476464", "type": "external" } ], "gene_names_uniprotkb": "Psmc1", "gene_names_refseq": "Psmc1; s4", "protein_names_uniprotkb": "26S proteasome regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; P26s4; Proteasome 26S subunit ATPase 1", "protein_names_refseq": "26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; P26s4; peptidase (prosome, macropain) 26S subunit, ATPase 1; protease (prosome, macropain) 26S subunit, ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1", "tax_id": 10116, "disease": "neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (Disease Ontology:DOID:0081324); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:117263); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-532668); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 1, "publication_id_list": "8607789", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P49014;Q03527;Q96AZ3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62193-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62749-1", "uniprot_id": [ { "id": "HPCL1_RAT", "url": "https://www.uniprot.org/uniprot/P62749", "type": "external" } ], "mass": 22338.0, "length": 193, "protein_name": "Hippocalcin-like protein 1", "gene_name": "Hpcal1", "organism": "Rat", "refseq_name": "hippocalcin-like protein 1", "refseq_ac": [ { "id": "NP_059052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059052", "type": "external" } ], "gene_names_uniprotkb": "Hpcal1", "gene_names_refseq": "Hpcal1; NVP-3; Nvp3; VILIP-3", "protein_names_uniprotkb": "Hippocalcin-like protein 1; NVL-3; NVP-3; Neural visinin-like protein 3; VILIP-3; Visinin-like protein 3", "protein_names_refseq": "NVL-3; hippocalcin-like protein 1; neural visinin-like Ca2+-binding protein type 3; neural visinin-like protein 3; visinin-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:50871)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12445467;14664824;8360675", "class_list": "", "function": "Direct comparison of the localization and calcium-dependent translocation of visinin-like-proteins 1 and 3 in hippocampal neurons, [RefSeq, PubMed]; Evidence for different functional properties of NVP-1 and NVP-3: from subcellular localization to cellular function., [RefSeq, PubMed]; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35333", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001889 liver development;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62749-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62817-1", "uniprot_id": [ { "id": "HRK_RAT", "url": "https://www.uniprot.org/uniprot/P62817", "type": "external" } ], "mass": 10078.0, "length": 92, "protein_name": "Activator of apoptosis harakiri", "gene_name": "Hrk", "organism": "Rat", "refseq_name": "activator of apoptosis harakiri", "refseq_ac": [ { "id": "NP_476471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476471", "type": "external" } ], "gene_names_uniprotkb": "Hrk; Bid3; Dp5", "gene_names_refseq": "Bid3; Dp5; Hrk", "protein_names_uniprotkb": "Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3; Neuronal death protein DP5", "protein_names_refseq": "BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3 interacting domain 3; BH3-interacting domain-containing protein 3; activator of apoptosis harakiri; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5", "tax_id": 10116, "disease": "", "pathway": " (rno:117271)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12700636;19629134;33603338;9228060", "class_list": "", "function": "BH3 peptide has a role in releasing cytochrome c in rat brain mitochondria, [RefSeq, PubMed]; Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes apoptosis., [UniProtKB]; The inactivation of hrk protein protects -cells from IL-1beta+IFN-gamma and chemical Endoplasmic Reticulum stress-mediated cell death., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70678", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031334 positive regulation of protein-containing complex assembly;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62817-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63031-1", "uniprot_id": [ { "id": "MPC1_RAT", "url": "https://www.uniprot.org/uniprot/P63031", "type": "external" } ], "mass": 12455.0, "length": 109, "protein_name": "Mitochondrial pyruvate carrier 1", "gene_name": "Mpc1", "organism": "Rat", "refseq_name": "mitochondrial pyruvate carrier 1", "refseq_ac": [ { "id": "NP_598245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598245", "type": "external" } ], "gene_names_uniprotkb": "Mpc1; Arbp; Brp44l", "gene_names_refseq": "Brp44l; Mpc1; SLC54A1", "protein_names_uniprotkb": "Mitochondrial pyruvate carrier 1; Apoptosis-regulating basic protein; Brain protein 44-like protein", "protein_names_refseq": "apoptosis-regulating basic protein; brain protein 44-like protein; mitochondrial pyruvate carrier 1; solute carrier family 54 member 1", "tax_id": 10116, "disease": "mitochondrial pyruvate carrier deficiency (Disease Ontology:DOID:0080363); intestinal cancer (Disease Ontology:DOID:10155); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:171087)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "34481907;37030616;38867145", "class_list": "", "function": "Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats., [RefSeq, PubMed]; Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (By similarity). Plays an essential role in cellular metabolism (By similarity)., [UniProtKB, UniProtKB]; Mediates the uptake of pyruvate into mitochondria., [UniProtKB, UniProtKB, UniProtKB]; Mitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8N5;Q9D6C0;Q9JLG5", "ec_number_list": [], "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006086 pyruvate decarboxylation to acetyl-CoA;GO:0006850 pyruvate import into mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63031-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63055-1", "uniprot_id": [ { "id": "PCP4_RAT", "url": "https://www.uniprot.org/uniprot/P63055", "type": "external" } ], "mass": 6807.0, "length": 62, "protein_name": "Calmodulin regulator protein PCP4", "gene_name": "Pcp4", "organism": "Rat", "refseq_name": "calmodulin regulator protein PCP4 isoform PEP19", "refseq_ac": [ { "id": "NP_037134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037134", "type": "external" } ], "gene_names_uniprotkb": "Pcp4; Pep19", "gene_names_refseq": "PEPZ19; Pcp4; pep-19", "protein_names_uniprotkb": "Calmodulin regulator protein PCP4; Brain-specific polypeptide PEP-19; Purkinje cell protein 4", "protein_names_refseq": "Neuron specific protein PEP-19 (Purkinje cell protein 4); brain-specific antigen PCP-4; brain-specific polypeptide PEP-19; calmodulin regulator protein PCP4 isoform PEP19; calmodulin regulator protein PCP4", "tax_id": 10116, "disease": "leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:25510)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22020791;22197496;25048017;2748608;3464961", "class_list": "", "function": "Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways., [UniProtKB, UniProtKB]; Overexpression of PEP-19 suppresses angiotensin II-induced cardiomyocyte hypertrophy., [RefSeq, PubMed]; PEP-19 and LPI bind H1 histone mRNA and that this binding is affected by calmodulin., [RefSeq, PubMed]; The protein encoded by this gene regulates H1˚ and H3.3 histone synthesis by binding to H1˚ and H3.3 histone mRNAs. The encoded protein can bind calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]; These findings suggest that PEP 19-ir neurons in the MDH may have a function in modulation of nociceptive and thermo-receptive signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P07734;Q63890", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005516 calmodulin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0005883 neurofilament;GO:0032991 protein-containing complex", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0045666 positive regulation of neuron differentiation;GO:0006469 negative regulation of protein kinase activity;GO:0043524 negative regulation of neuron apoptotic process;GO:0033603 positive regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63055-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63057-1", "uniprot_id": [ { "id": "NOE3_RAT", "url": "https://www.uniprot.org/uniprot/P63057", "type": "external" } ], "mass": 54886.0, "length": 478, "protein_name": "Noelin-3", "gene_name": "Olfm3", "organism": "Rat", "refseq_name": "noelin-3 precursor", "refseq_ac": [ { "id": "NP_665720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665720", "type": "external" } ], "gene_names_uniprotkb": "Olfm3; Noe3", "gene_names_refseq": "Olfm3", "protein_names_uniprotkb": "Noelin-3; Olfactomedin-3; Optimedin", "protein_names_refseq": "noelin-3 precursor; noelin-3; optimedin", "tax_id": 10116, "disease": "", "pathway": " (rno:252920)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12019210;16115881;22632720", "class_list": "", "function": "Pax6 regulation of Optimedin in the eye and brain may directly affect multiple developmental processes, including cell migration and axon growth, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8BKV2;Q8BLL6;Q8QZW0;Q8R4K3;Q8R4K4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0032281 AMPA glutamate receptor complex", "go_biological_process": "GO:0007165 signal transduction;GO:0042462 eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P63057-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63251-1", "uniprot_id": [ { "id": "KCNJ3_RAT", "url": "https://www.uniprot.org/uniprot/P63251", "type": "external" } ], "mass": 56573.0, "length": 501, "protein_name": "G protein-activated inward rectifier potassium channel 1", "gene_name": "Kcnj3", "organism": "Rat", "refseq_name": "G protein-activated inward rectifier potassium channel 1", "refseq_ac": [ { "id": "NP_113798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113798", "type": "external" } ], "gene_names_uniprotkb": "Kcnj3; Girk1; Kga", "gene_names_refseq": "Kcnj3", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; KGA; KGB1; Potassium channel, inwardly rectifying subfamily J member 3", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 1; GIRK-1; GIRK1; KGA; KGB1; inward rectifier K(+) channel Kir3.1; potassium channel inwarding rectifying channel subfamily J member 3; potassium channel subunit Kir3.1 type 3 delta; potassium channel, inwardly rectifying subfamily J member 3; potassium voltage-gated channel subfamily J member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:50599); (R-RNO-1296041); (R-RNO-997272)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "26199148;26460748;28009293;28205094;28951616;7704424;8234283;8355805;8642402;8670306;9486652", "class_list": "", "function": "Fourteen days after axotomy, GIRK1 and GIRK2 were down-regulated in DRG neurons at the mRNA and protein levels. Publication Status: Online-Only, [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8234283, PubMed:8355805, PubMed:9486652). This receptor plays a crucial role in regulating the heartbeat (PubMed:8234283). Forms a functional channel in association with KCNJ9/GIRK3 (PubMed:8670306)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Inwardly rectifying K+ channels coupled to 5-HT1A autoreceptors display pharmacological properties generally expected for neuronal GIRK channels, but different from GIRK1-GIRK2 heteromers Publication Status: Online-Only, [RefSeq, PubMed]; Study is first to show direct cleavage of GIRK1 and GIRK2 subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390) and GIRK2 (349YEVD352) and suggests the possible role of caspase-3 mediated down-regulation of GIRK channel function and expression in hippocampal neuronal injury during prolonged epileptic seizures. Publication Status: Online-Only, [RefSeq, PubMed]; Study provides evidence that Kir3.1 is involved in the pathogenesis of sinus bradycardia since its ihibition with siRNA can reverse the sinus bradycardia., [RefSeq, PubMed]; Transient activation of mGluRs decreased the GIRK current evoked by GABAB and D2 receptors, although less efficaciously for D2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P35562", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051602 response to electrical stimulus;GO:1990573 potassium ion import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69060-1", "uniprot_id": [ { "id": "NEUA_RAT", "url": "https://www.uniprot.org/uniprot/P69060", "type": "external" } ], "mass": 48129.0, "length": 432, "protein_name": "N-acylneuraminate cytidylyltransferase", "gene_name": "Cmas", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cmas", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acylneuraminate cytidylyltransferase; 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase", "protein_names_refseq": "", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (rno:312826); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.43", "type": "external" } ], "go_molecular_function": "GO:0008781 N-acylneuraminate cytidylyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P69060-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70585-1", "uniprot_id": [ { "id": "GPR19_RAT", "url": "https://www.uniprot.org/uniprot/P70585", "type": "external" } ], "mass": 47634.0, "length": 415, "protein_name": "Probable G protein-coupled receptor 19", "gene_name": "Gpr19", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 19", "refseq_ac": [ { "id": "NP_542146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542146", "type": "external" } ], "gene_names_uniprotkb": "Gpr19", "gene_names_refseq": "Gpr19", "protein_names_uniprotkb": "Probable G protein-coupled receptor 19", "protein_names_refseq": "probable G-protein coupled receptor 19", "tax_id": 10116, "disease": "", "pathway": " (rno:312787)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26739651;29909017;8830667", "class_list": "", "function": "G protein-coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism (PubMed:26739651). Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain (By similarity). May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence (By similarity). Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity (PubMed:29909017)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; G-protein coupled receptor that plays a role in the regulation of circadian rhythms and energy metabolism. Participates in maintaining proper circadian gene expression in the suprachiasmatic nucleus (SCN), the locus of the master circadian clock in the brain. May function as a coordinator of aging-associated metabolic dysfunction, stress response, DNA integrity management, and eventual senescence. Upon binding to adropin, modulates mitochondrial energy metabolism via the p44/42-PDK4 signaling pathway, influencing pyruvate dehydrogenase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVI1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70585-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70595-1", "uniprot_id": [ { "id": "NGN1_RAT", "url": "https://www.uniprot.org/uniprot/P70595", "type": "external" } ], "mass": 26182.0, "length": 244, "protein_name": "Neurogenin-1", "gene_name": "Neurog1", "organism": "Rat", "refseq_name": "neurogenin-1", "refseq_ac": [ { "id": "NP_062080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062080", "type": "external" } ], "gene_names_uniprotkb": "Neurog1; Neurod3; Ngn1; Ngn", "gene_names_refseq": "Neurod3; Neurog1; Ngn1", "protein_names_uniprotkb": "Neurogenin-1; NGN-1; NeuroD3; Neurogenic basic-helix-loop-helix protein; Neurogenic differentiation factor 3", "protein_names_refseq": "NGN-1; neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; neurogenic differentiation factor 3; neurogenin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:29410)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11923194;27573468;8858147", "class_list": "", "function": "Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)., [UniProtKB, UniProtKB]; Beta-Catenin siRNA reduces Ngnl1 and increases BMP4 mRNA expression levels in rat neural stem cells., [RefSeq, PubMed]; Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0048806 genitalia development;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0048634 regulation of muscle organ development;GO:0071626 mastication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70595-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70619-1", "uniprot_id": [ { "id": "GSHR_RAT", "url": "https://www.uniprot.org/uniprot/P70619", "type": "external" } ], "mass": 46301.0, "length": 424, "protein_name": "Glutathione reductase", "gene_name": "Gsr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gsr", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione reductase; 1.8.1.7; GRase; GR", "protein_names_refseq": "", "tax_id": 10116, "disease": "hemorrhagic cystitis (Disease Ontology:DOID:0050859); congenital nonspherocytic hemolytic anemia 10 (Disease Ontology:DOID:0051009); myoglobinuria (Disease Ontology:DOID:0080108); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Parkinsonism (Disease Ontology:DOID:0080855); Heinz body anemia (Disease Ontology:DOID:0111363); lymphoid leukemia (Disease Ontology:DOID:1037); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); diabetic angiopathy (Disease Ontology:DOID:11713); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); iron deficiency anemia (Disease Ontology:DOID:11758); beta thalassemia (Disease Ontology:DOID:12241); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); diabetic cataract (Disease Ontology:DOID:13328); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); macular degeneration (Disease Ontology:DOID:4448); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); congenital hemolytic anemia (Disease Ontology:DOID:589); peptic ulcer disease (Disease Ontology:DOID:750); end stage renal disease (Disease Ontology:DOID:783); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); alcoholic gastritis (Disease Ontology:DOID:8680); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-RNO-3299685); (R-RNO-499943); (R-RNO-5628897)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0043295 glutathione binding;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0035094 response to nicotine;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P70619-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80250-1", "uniprot_id": [ { "id": "PMCH_RAT", "url": "https://www.uniprot.org/uniprot/P80250", "type": "external" } ], "mass": 6919.0, "length": 64, "protein_name": "Palmitoyl-CoA hydrolase", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Palmitoyl-CoA hydrolase; 3.1.2.2; Long-chain fatty-acyl-CoA hydrolase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8100522", "class_list": "", "function": "Hydrolysis of a variety of CoA thioesters of long-chain fatty acids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80250-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83556-1", "uniprot_id": [ { "id": "KI3L1_RAT", "url": "https://www.uniprot.org/uniprot/P83556", "type": "external" } ], "mass": 48074.0, "length": 422, "protein_name": "Killer cell immunoglobulin-like receptor 3DL1", "gene_name": "Kir3dl1", "organism": "Rat", "refseq_name": "killer cell immunoglobulin-like receptor 3DL1 precursor", "refseq_ac": [ { "id": "NP_852144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852144", "type": "external" } ], "gene_names_uniprotkb": "Kir3dl1", "gene_names_refseq": "Kir3dl1", "protein_names_uniprotkb": "Killer cell immunoglobulin-like receptor 3DL1", "protein_names_refseq": "killer cell immunoglobulin-like receptor 3DL1 precursor; killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1", "tax_id": 10116, "disease": "Polyomavirus-associated nephropathy (Disease Ontology:DOID:0040086); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); COVID-19 (Disease Ontology:DOID:0080600); human cytomegalovirus infection (Disease Ontology:DOID:0080827); dengue hemorrhagic fever (Disease Ontology:DOID:12206); malaria (Disease Ontology:DOID:12365); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); West Nile fever (Disease Ontology:DOID:2366); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); syphilis (Disease Ontology:DOID:4166); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (rno:353253); (R-RNO-198933)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12594244", "class_list": "", "function": "Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83556-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83581-1", "uniprot_id": [ { "id": "HS74L_RAT", "url": "https://www.uniprot.org/uniprot/P83581", "type": "external" } ], "mass": 2796.0, "length": 24, "protein_name": "Heat shock 70 kDa protein 4L", "gene_name": "Hspa4l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hspa4l; Apg1; Hsp4l; Hsph3; Osp94", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4L; Heat shock 70-related protein APG-1; Osmotic stress protein 94", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "10806408;12423363;1893998;2226463;22673903", "class_list": "", "function": "Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P83581-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83953-1", "uniprot_id": [ { "id": "IMA5_RAT", "url": "https://www.uniprot.org/uniprot/P83953", "type": "external" } ], "mass": 60137.0, "length": 538, "protein_name": "Importin subunit alpha-5", "gene_name": "Kpna1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kpna1", "gene_names_refseq": "", "protein_names_uniprotkb": "Importin subunit alpha-5; Importin alpha-5; Karyopherin subunit alpha-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-140342); (R-RNO-68616); (R-RNO-909733)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15094201;18303947", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:18303947). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:18303947). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:18303947). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:18303947). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:18303947). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Functions in nuclear protein import., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0042981 regulation of apoptotic process;GO:0060828 regulation of canonical Wnt signaling pathway;GO:0006607 NLS-bearing protein import into nucleus;GO:0014841 skeletal muscle satellite cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P83953-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84588-1", "uniprot_id": [ { "id": "HSP7D_RAT", "url": "https://www.uniprot.org/uniprot/P84588", "type": "external" } ], "mass": 1306.0, "length": 13, "protein_name": "Heat shock cognate 71 kDa protein 2", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16128803", "class_list": "", "function": "Chaperone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0016363 nuclear matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84588-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86172-1", "uniprot_id": [ { "id": "NMRL1_RAT", "url": "https://www.uniprot.org/uniprot/P86172", "type": "external" } ], "mass": 16901.0, "length": 150, "protein_name": "NmrA-like family domain-containing protein 1", "gene_name": "Nmral1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nmral1", "gene_names_refseq": "", "protein_names_uniprotkb": "NmrA-like family domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287063)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P86172-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97519-1", "uniprot_id": [ { "id": "HMGCL_RAT", "url": "https://www.uniprot.org/uniprot/P97519", "type": "external" } ], "mass": 34192.0, "length": 325, "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "gene_name": "Hmgcl", "organism": "Rat", "refseq_name": "hydroxymethylglutaryl-CoA lyase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_077362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077362", "type": "external" } ], "gene_names_uniprotkb": "Hmgcl", "gene_names_refseq": "Hmgcl", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA lyase, mitochondrial; 3-hydroxy-3-methylglutarate-CoA lyase; 4.1.3.4; HL; HMG-CoA lyase", "protein_names_refseq": "3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxy-3-methylglutaryl-Coenzyme A lyase; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; HL; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial precursor; hydroxymethylglutaryl-CoA lyase, mitochondrial", "tax_id": 10116, "disease": "3-hydroxy-3-methylglutaryl-CoA lyase deficiency (Disease Ontology:DOID:0070541); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:79238); (R-RNO-77111); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19460629;9425122", "class_list": "", "function": "Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the in vitro effects of 3-hydroxy-3-methylglutarate metabolites in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency on parameters of oxidative stress in striatum and liver., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001889 liver development;GO:0006629 lipid metabolic process;GO:0006637 acyl-CoA metabolic process;GO:0007584 response to nutrient;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97519-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97557-1", "uniprot_id": [ { "id": "KCNV1_RAT", "url": "https://www.uniprot.org/uniprot/P97557", "type": "external" } ], "mass": 56663.0, "length": 503, "protein_name": "Potassium voltage-gated channel subfamily V member 1", "gene_name": "Kcnv1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily V member 1", "refseq_ac": [ { "id": "NP_067729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067729", "type": "external" } ], "gene_names_uniprotkb": "Kcnv1", "gene_names_refseq": "Kcnv1; Kv8.1; kv2.3r", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily V member 1; Voltage-gated potassium channel subunit Kv2.3r; Voltage-gated potassium channel subunit Kv8.1", "protein_names_refseq": "neuronal potassium channel alpha subunit; potassium channel, subfamily V, member 1; potassium channel, voltage-gated modifier subfamily V, member 1; potassium voltage-gated channel subfamily V member 1; voltage-gated potassium channel subunit Kv2.3r; voltage-gated potassium channel subunit Kv8.1", "tax_id": 10116, "disease": "", "pathway": " (rno:60326); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9169526", "class_list": "", "function": "Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97557-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97604-1", "uniprot_id": [ { "id": "IL15_RAT", "url": "https://www.uniprot.org/uniprot/P97604", "type": "external" } ], "mass": 18804.0, "length": 162, "protein_name": "Interleukin-15", "gene_name": "Il15", "organism": "Rat", "refseq_name": "interleukin-15 preproprotein", "refseq_ac": [ { "id": "NP_037261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037261", "type": "external" } ], "gene_names_uniprotkb": "Il15", "gene_names_refseq": "Il15", "protein_names_uniprotkb": "Interleukin-15; IL-15", "protein_names_refseq": "IL-15; interleukin-15 preproprotein", "tax_id": 10116, "disease": "pleurisy (Disease Ontology:DOID:10247); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); listeriosis (Disease Ontology:DOID:11573); pulmonary sarcoidosis (Disease Ontology:DOID:13406); aspergillosis (Disease Ontology:DOID:13564); arteriosclerosis (Disease Ontology:DOID:2349); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); periodontal disease (Disease Ontology:DOID:3388); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); pulmonary fibrosis (Disease Ontology:DOID:3770); pancreatitis (Disease Ontology:DOID:4989); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); lung disease (Disease Ontology:DOID:850); viral infectious disease (Disease Ontology:DOID:934); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25670); (R-RNO-8983432)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "29097254;33010727;8942753", "class_list": "", "function": "Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity)., [UniProtKB, UniProtKB]; Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats., [RefSeq, PubMed]; These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O54847", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005126 cytokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0016607 nuclear speck", "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0032740 positive regulation of interleukin-17 production;GO:0045062 extrathymic T cell selection;GO:1904100 positive regulation of protein O-linked glycosylation;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97604-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97678-1", "uniprot_id": [ { "id": "KCMB1_RAT", "url": "https://www.uniprot.org/uniprot/P97678", "type": "external" } ], "mass": 21909.0, "length": 191, "protein_name": "Calcium-activated potassium channel subunit beta-1", "gene_name": "Kcnmb1", "organism": "Rat", "refseq_name": "calcium-activated potassium channel subunit beta-1", "refseq_ac": [ { "id": "NP_062146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062146", "type": "external" } ], "gene_names_uniprotkb": "Kcnmb1", "gene_names_refseq": "BKbeta1; BKbeta; Kcnmb1; k(VCA)beta-1; slo-beta-1; slo-beta", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-1; BK channel subunit beta-1; BKbeta1; BKbeta; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta-1; Slo-beta; Slowpoke-beta", "protein_names_refseq": "BK channel subunit beta-1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel subunit beta; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; maxi K channel subunit beta-1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slowpoke-beta", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29747); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12890510;14551242;30012867;31738403;32967457;33556372;36717168;9105668;9888999", "class_list": "", "function": "Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner., [RefSeq, PubMed]; Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring., [RefSeq, PubMed]; Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma., [RefSeq, PubMed]; Data show that potassium channel subfamily M regulatory beta subunit 1 (beta1 Subunit) surface trafficking is Impaired in cerebral arteries of stroke-prone spontaneously hypertensive rats (SP-SHRs)., [RefSeq, PubMed]; Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins., [RefSeq, PubMed]; Kvbeta 1.1 contributes to the developmental control of the A-typepotassium channel current in hippocampal neurons., [RefSeq, PubMed]; Lower expression of the beta1 subunit during genetic borderline and severe hypertension reduced BK channel activity by decreasing the sensitivity of these channels to physiological changes in Ca2+, [RefSeq, PubMed]; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35337;O88805;Q9ESK7;Q9QWI7", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0008076 voltage-gated potassium channel complex;GO:0036477 somatodendritic compartment", "go_biological_process": "GO:0051592 response to calcium ion;GO:0042311 vasodilation;GO:0071456 cellular response to hypoxia;GO:0071361 cellular response to ethanol;GO:1901381 positive regulation of potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97678-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00238-1", "uniprot_id": [ { "id": "ICAM1_RAT", "url": "https://www.uniprot.org/uniprot/Q00238", "type": "external" } ], "mass": 60142.0, "length": 545, "protein_name": "Intercellular adhesion molecule 1", "gene_name": "Icam1", "organism": "Rat", "refseq_name": "intercellular adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_037099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037099", "type": "external" } ], "gene_names_uniprotkb": "Icam1", "gene_names_refseq": "CD54; ICAM; Icam1; RICAM-I", "protein_names_uniprotkb": "Intercellular adhesion molecule 1; ICAM-1; RICAM-I", "protein_names_refseq": "ICAM-1; intercellular adhesion molecule 1 precursor", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); colitis (Disease Ontology:DOID:0060180); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Prinzmetal angina (Disease Ontology:DOID:0111151); venous insufficiency (Disease Ontology:DOID:10128); aortic atherosclerosis (Disease Ontology:DOID:10230); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); allergic conjunctivitis (Disease Ontology:DOID:11204); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); mesenteric vascular occlusion (Disease Ontology:DOID:13252); biliary atresia (Disease Ontology:DOID:13608); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); bronchus carcinoma (Disease Ontology:DOID:3904); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); brain edema (Disease Ontology:DOID:4724); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); localized scleroderma (Disease Ontology:DOID:8472); rheumatic myocarditis (Disease Ontology:DOID:8481); bullous pemphigoid (Disease Ontology:DOID:8506); chronic ulcer of skin (Disease Ontology:DOID:8549); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25464); (R-RNO-198933); (R-RNO-216083)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1349828;34147590;35218622;35851539;37901475;37952156", "class_list": "", "function": "Actin-binding protein, IQGAP1, regulates LPS-induced RPMVECs hyperpermeability and ICAM-1 upregulation via Rap1/Src signalling pathway., [RefSeq, PubMed]; Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ET-1 receptor type B (ETBR) overexpression associated with ICAM-1 downregulation leads to inflammatory attenuation in experimental autoimmune myocarditis. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia-sensitive cells trigger NK cell activation via the KLF4-ASH1L-ICAM-1 axis, contributing to impairment in the rat epididymis., [RefSeq, PubMed]; ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-kappaB in Pancreatic beta-Cells., [RefSeq, PubMed]; [Acupoint catgut embedment may reduce airway inflammation reaction by down-regulating ICAM-1 and EOS by suppressing p38MAPK signaling in lung tissue of asthmatic rats]., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 87, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0044877 protein-containing complex binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0070062 extracellular exosome", "go_biological_process": "GO:1900027 regulation of ruffle assembly;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0002457 T cell antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00238-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01066-1", "uniprot_id": [ { "id": "PDE1B_RAT", "url": "https://www.uniprot.org/uniprot/Q01066", "type": "external" } ], "mass": 61260.0, "length": 535, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B", "gene_name": "Pde1b", "organism": "Rat", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B", "refseq_ac": [ { "id": "NP_073201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073201", "type": "external" } ], "gene_names_uniprotkb": "Pde1b; Pde1b1", "gene_names_refseq": "Aop2; Pde1b1; Pde1b", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; 3.1.4.17; 63 kDa Cam-PDE; Cam-PDE 1B", "protein_names_refseq": "63 kDa Cam-PDE; anti-oxidant protein 2; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; cyclic nucleotide phosphodiesterase (CaM-PDE); dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; phosphodiesterase 1B, Ca2+calmodulin dependent; phosphodiesterase 1B, calmodulin-dependent; phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa; phosphodiesterase IB calmodulin-dependent", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855)", "pathway": " (rno:29691); (R-RNO-111957); (R-RNO-418457); (R-RNO-418555)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1326532;22673903;33444639", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q548L3", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0001975 response to amphetamine;GO:0042428 serotonin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01066-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01714-1", "uniprot_id": [ { "id": "SP1_RAT", "url": "https://www.uniprot.org/uniprot/Q01714", "type": "external" } ], "mass": 80772.0, "length": 786, "protein_name": "Transcription factor Sp1", "gene_name": "Sp1", "organism": "Rat", "refseq_name": "transcription factor Sp1", "refseq_ac": [ { "id": "NP_036787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036787", "type": "external" } ], "gene_names_uniprotkb": "Sp1", "gene_names_refseq": "Sp1", "protein_names_uniprotkb": "Transcription factor Sp1", "protein_names_refseq": "trans-acting transcription factor 1; transcription factor Sp1", "tax_id": 10116, "disease": "", "pathway": " (rno:24790); (R-RNO-2173796); (R-RNO-6807505); (R-RNO-9762293)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "12379234;12397027;12941958;1356762;14675536;16052526;16332679;16365142;19081374;20851344;22673903;37556489;38163563;38301049;39153708;39288622;9111324", "class_list": "", "function": "Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis., [RefSeq, PubMed]; Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification., [RefSeq, PubMed]; MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats., [RefSeq, PubMed]; SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP., [RefSeq, PubMed]; Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Also binds the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component BMAL1 (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter (PubMed:19081374). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 5, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4R0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0043353 enucleate erythrocyte differentiation;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q01714-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01984-1", "uniprot_id": [ { "id": "HNMT_RAT", "url": "https://www.uniprot.org/uniprot/Q01984", "type": "external" } ], "mass": 33942.0, "length": 295, "protein_name": "Histamine N-methyltransferase", "gene_name": "Hnmt", "organism": "Rat", "refseq_name": "histamine N-methyltransferase", "refseq_ac": [ { "id": "NP_112306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112306", "type": "external" } ], "gene_names_uniprotkb": "Hnmt", "gene_names_refseq": "Hnmt", "protein_names_uniprotkb": "Histamine N-methyltransferase; 2.1.1.8; HMT", "protein_names_refseq": "HMT; histamine N-methyltransferase", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 51 (Disease Ontology:DOID:0081214); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); brain infarction (Disease Ontology:DOID:3454); essential tremor (Disease Ontology:DOID:4990); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:81676)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11855681;1639806", "class_list": "", "function": "Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59JM9", "ec_number_list": [ { "id": "2.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20", "type": "external" }, { "id": "2.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0008170 N-methyltransferase activity;GO:0046539 histamine N-methyltransferase activity;GO:0098603 selenol Se-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051384 response to glucocorticoid;GO:0042220 response to cocaine;GO:0070555 response to interleukin-1;GO:0032259 methylation;GO:0035902 response to immobilization stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q01984-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02974-1", "uniprot_id": [ { "id": "KHK_RAT", "url": "https://www.uniprot.org/uniprot/Q02974", "type": "external" } ], "mass": 32749.0, "length": 298, "protein_name": "Ketohexokinase", "gene_name": "Khk", "organism": "Rat", "refseq_name": "ketohexokinase isoform 1", "refseq_ac": [ { "id": "NP_114061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114061", "type": "external" } ], "gene_names_uniprotkb": "Khk", "gene_names_refseq": "KETHPRO; Khk", "protein_names_uniprotkb": "Ketohexokinase; 2.7.1.3; Hepatic fructokinase", "protein_names_refseq": "hepatic fructokinase; ketohexokinase isoform 1", "tax_id": 10116, "disease": "essential fructosuria (Disease Ontology:DOID:0111680)", "pathway": " (rno:25659); (R-RNO-70350)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21122807;8471037;9799106", "class_list": "", "function": "Atorvastatin decreased the expression of fructokinase in livers of fructose-supplemented rats, reducing the metabolic burden on the liver that is imposed by continuous fructose ingestion., [RefSeq, PubMed]; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97550;P97551", "ec_number_list": [ { "id": "2.7.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0070061 fructose binding;GO:0004454 ketohexokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010043 response to zinc ion;GO:0032868 response to insulin;GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0009749 response to glucose;GO:0006000 fructose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02974-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03062-1", "uniprot_id": [ { "id": "HES5_RAT", "url": "https://www.uniprot.org/uniprot/Q03062", "type": "external" } ], "mass": 18452.0, "length": 166, "protein_name": "Transcription factor HES-5", "gene_name": "Hes5", "organism": "Rat", "refseq_name": "transcription factor HES-5", "refseq_ac": [ { "id": "NP_077359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077359", "type": "external" } ], "gene_names_uniprotkb": "Hes5; Hes-5", "gene_names_refseq": "Hes5", "protein_names_uniprotkb": "Transcription factor HES-5; Hairy and enhancer of split 5", "protein_names_refseq": "hairy and enhancer of split 5; transcription factor HES-5", "tax_id": 10116, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:79225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1400497;22334042;30811836", "class_list": "", "function": "Folic acid stimulated the expression of Notch1, Hes1, and Hes5 proteins, and this effect increased with folic acid dose in the rat middle cerebral artery occlusion model of stroke., [RefSeq, PubMed]; Monocrotaline-induced pulmonary hypertension rats had high expressions of the Notch3-HES5 signal pathway in the pulmonary arterioles., [RefSeq, PubMed]; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021781 glial cell fate commitment;GO:0072086 specification of loop of Henle identity;GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation;GO:0048708 astrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q03062-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07014-1", "uniprot_id": [ { "id": "LYN_RAT", "url": "https://www.uniprot.org/uniprot/Q07014", "type": "external" } ], "mass": 58660.0, "length": 512, "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "Lyn", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Lyn isoform B", "refseq_ac": [ { "id": "NP_001104568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104568", "type": "external" } ], "gene_names_uniprotkb": "Lyn", "gene_names_refseq": "Lyn; p53Lyn; p56Lyn", "protein_names_uniprotkb": "Tyrosine-protein kinase Lyn; 2.7.10.2; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn", "protein_names_refseq": "Yamaguchi sarcoma viral (v-yes-1) oncogene homolog; lyn protein non-receptor kinase; tyrosine-protein kinase Lyn isoform B; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); endometriosis (Disease Ontology:DOID:289); Goldenhar syndrome (Disease Ontology:DOID:2907); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:81515); (R-RNO-114604); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-2029481); (R-RNO-210990); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-389356); (R-RNO-389513); (R-RNO-3928662); (R-RNO-3928663); (R-RNO-3928665); (R-RNO-5621480); (R-RNO-5621575); (R-RNO-5690714); (R-RNO-69231); (R-RNO-75892); (R-RNO-9006335); (R-RNO-9027276); (R-RNO-9027284); (R-RNO-912631); (R-RNO-9674555); (R-RNO-9705462); (R-RNO-982772)", "pathway_count": 28, "publication_count": 5, "publication_id_list": "22673903;25289695;8125304;9295361;9477973", "class_list": "", "function": "Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Involved in the regulation of endothelial activation, neutrophil adhesion and transendothelial migration (By similarity). Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B (By similarity). Phosphorylates LPXN on 'Tyr-72' (By similarity). Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-96'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study reveals a complex regulation for PLSCR1 tyrosine phosphorylation in FcepsilonRI-activated mast cells, and that PLSCR1 sits at a crossroads between Lyn and Fyn pathways. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63320", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:1902532 negative regulation of intracellular signal transduction;GO:0060252 positive regulation of glial cell proliferation;GO:0002431 Fc receptor mediated stimulatory signaling pathway;GO:0002513 tolerance induction to self antigen", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07014-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08755-1", "uniprot_id": [ { "id": "INSI1_RAT", "url": "https://www.uniprot.org/uniprot/Q08755", "type": "external" } ], "mass": 28232.0, "length": 259, "protein_name": "Insulin-induced gene 1 protein", "gene_name": "Insig1", "organism": "Rat", "refseq_name": "insulin-induced gene 1 protein", "refseq_ac": [ { "id": "NP_071787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071787", "type": "external" } ], "gene_names_uniprotkb": "Insig1; Cl-6", "gene_names_refseq": "Insig1", "protein_names_uniprotkb": "Insulin-induced gene 1 protein; INSIG-1; Immediate-early protein CL-6; Insulin-induced growth response protein CL-6", "protein_names_refseq": "INSIG-1; growth response protein (CL-6); immediate-early protein CL-6; insulin-induced gene 1 protein; insulin-induced growth response protein CL-6", "tax_id": 10116, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:64194)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21843373;23913732;26007286;29393594;7686911", "class_list": "", "function": "Data suggest expression of hepatocyte Insig1/Insig2a and Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3 protein) can be up-regulated by dietary factors (here, dietary supplementation with hypotriglyceridemic R-alpha-lipoic acid)., [RefSeq, PubMed]; INSIG-1 is decreased by insulin in liver and increased in fat., [RefSeq, PubMed]; Overexpression of Insig-1 protects beta cells against glucolipotoxicity via SREBP-1c. Publication Status: Online-Only, [RefSeq, PubMed]; Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032937 SREBP-SCAP-Insig complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q08755-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0ZUP0-1", "uniprot_id": [ { "id": "KLRB1_RAT", "url": "https://www.uniprot.org/uniprot/Q0ZUP0", "type": "external" } ], "mass": 23963.0, "length": 214, "protein_name": "Killer cell lectin-like receptor subfamily B member 1", "gene_name": "Klrb1", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily B member 1", "refseq_ac": [ { "id": "NP_001078874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078874", "type": "external" } ], "gene_names_uniprotkb": "Klrb1; Klrb1d; Klrb1g; Klrb6; Nkrp1e; Nkrp1g", "gene_names_refseq": "Klrb1d; Klrb1f; Klrb1g; Klrb1; Klrb6; NKR-P1G; Nkr-p1e; Nkrp-1e", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1; Immunoreceptor NKR-P1E; Killer cell lectin-like receptor subfamily B member 1G; Natural killer cell surface protein NKR-P1G; Natural killer lectin-like receptor 1E", "protein_names_refseq": "immunoreceptor NKR-P1E; killer cell lectin like receptor B1; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B member 1; natural killer cell surface protein NKR-P1G; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:689817)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17462921;25382546", "class_list": "", "function": "NKR-P1F and NKR-P1G receptors expressed by NK cells and T lymphocytes in liver and gut have been functionally characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0ZUP0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RP77-1", "uniprot_id": [ { "id": "NOP16_RAT", "url": "https://www.uniprot.org/uniprot/Q1RP77", "type": "external" } ], "mass": 21117.0, "length": 178, "protein_name": "Nucleolar protein 16", "gene_name": "Nop16", "organism": "Rat", "refseq_name": "nucleolar protein 16", "refseq_ac": [ { "id": "NP_001040560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040560", "type": "external" } ], "gene_names_uniprotkb": "Nop16", "gene_names_refseq": "Nop16; RGD1305727", "protein_names_uniprotkb": "Nucleolar protein 16; Protein ZH1", "protein_names_refseq": "NOP16 nucleolar protein homolog; nucleolar protein 16", "tax_id": 10116, "disease": "", "pathway": " (rno:306768)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RP77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2V057-1", "uniprot_id": [ { "id": "HYPDH_RAT", "url": "https://www.uniprot.org/uniprot/Q2V057", "type": "external" } ], "mass": 51002.0, "length": 456, "protein_name": "Hydroxyproline dehydrogenase", "gene_name": "Prodh2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prodh2; Hypdh", "gene_names_refseq": "", "protein_names_uniprotkb": "Hydroxyproline dehydrogenase; 1.5.5.2; 1.5.5.3; HYPDH; Probable proline dehydrogenase 2; Probable proline oxidase 2; Proline oxidase-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-389661); (R-RNO-70688)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.2", "type": "external" }, { "id": "1.5.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.3", "type": "external" } ], "go_molecular_function": "GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors;GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2V057-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8N8-1", "uniprot_id": [ { "id": "PESC_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8N8", "type": "external" } ], "mass": 67604.0, "length": 586, "protein_name": "Pescadillo homolog", "gene_name": "Pes1", "organism": "Rat", "refseq_name": "pescadillo homolog", "refseq_ac": [ { "id": "NP_001037693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037693", "type": "external" } ], "gene_names_uniprotkb": "Pes1; PES1", "gene_names_refseq": "Pes1", "protein_names_uniprotkb": "Pescadillo homolog", "protein_names_refseq": "pescadillo homolog 1, containing BRCT domain; pescadillo homolog", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (rno:289740); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0000793 condensed chromosome", "go_biological_process": "GO:0007000 nucleolus organization;GO:0008283 cell population proliferation;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B8N8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRE6-1", "uniprot_id": [ { "id": "KLDC2_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRE6", "type": "external" } ], "mass": 45926.0, "length": 406, "protein_name": "Kelch domain-containing protein 2", "gene_name": "Klhdc2", "organism": "Rat", "refseq_name": "kelch domain-containing protein 2", "refseq_ac": [ { "id": "NP_001029305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029305", "type": "external" } ], "gene_names_uniprotkb": "Klhdc2; Klhdc2l1", "gene_names_refseq": "Klhdc2", "protein_names_uniprotkb": "Kelch domain-containing protein 2", "protein_names_refseq": "kelch domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:299113)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (By similarity). The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (By similarity). May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016604 nuclear body;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3KRE6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXN4-1", "uniprot_id": [ { "id": "NDC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXN4", "type": "external" } ], "mass": 75713.0, "length": 673, "protein_name": "Nucleoporin NDC1", "gene_name": "Ndc1", "organism": "Rat", "refseq_name": "nucleoporin NDC1", "refseq_ac": [ { "id": "NP_001020194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020194", "type": "external" } ], "gene_names_uniprotkb": "Ndc1; Tmem48", "gene_names_refseq": "Ndc1; Tmem48", "protein_names_uniprotkb": "Nucleoporin NDC1; Transmembrane protein 48", "protein_names_refseq": "nucleoporin NDC1; transmembrane protein 48", "tax_id": 10116, "disease": "", "pathway": " (rno:362557); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-9615933)", "pathway_count": 19, "publication_count": 1, "publication_id_list": "16600873", "class_list": "", "function": "Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0007283 spermatogenesis;GO:0015031 protein transport;GO:0007129 homologous chromosome pairing at meiosis;GO:0051292 nuclear pore complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499T2-1", "uniprot_id": [ { "id": "GILT_RAT", "url": "https://www.uniprot.org/uniprot/Q499T2", "type": "external" } ], "mass": 27644.0, "length": 248, "protein_name": "Gamma-interferon-inducible lysosomal thiol reductase", "gene_name": "Ifi30", "organism": "Rat", "refseq_name": "gamma-interferon-inducible lysosomal thiol reductase precursor", "refseq_ac": [ { "id": "NP_001025197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025197", "type": "external" } ], "gene_names_uniprotkb": "Ifi30", "gene_names_refseq": "Ifi30", "protein_names_uniprotkb": "Gamma-interferon-inducible lysosomal thiol reductase; 1.8.4.-; Interferon gamma inducible protein 30", "protein_names_refseq": "gamma-interferon-inducible lysosomal thiol reductase precursor; gamma-interferon-inducible lysosomal thiol reductase; interferon gamma inducible protein 30", "tax_id": 10116, "disease": "", "pathway": " (rno:290644); (R-RNO-2132295)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal thiol reductase that can reduce protein disulfide bonds. Facilitates the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing., [UniProtKB, UniProtKB]; Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction. Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate. Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme. Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction. Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0J7", "ec_number_list": [ { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0050821 protein stabilization;GO:0048147 negative regulation of fibroblast proliferation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499T2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63081-1", "uniprot_id": [ { "id": "PDIA6_RAT", "url": "https://www.uniprot.org/uniprot/Q63081", "type": "external" } ], "mass": 48173.0, "length": 440, "protein_name": "Protein disulfide-isomerase A6", "gene_name": "Pdia6", "organism": "Rat", "refseq_name": "protein disulfide-isomerase A6 precursor", "refseq_ac": [ { "id": "NP_001004442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004442", "type": "external" } ], "gene_names_uniprotkb": "Pdia6; Cabp1; Txndc7", "gene_names_refseq": "CaBP1; P5; Pdia6; Txndc7", "protein_names_uniprotkb": "Protein disulfide-isomerase A6; 5.3.4.1; CaBP1; Calcium-binding protein 1; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7", "protein_names_refseq": "calcium-binding protein 1; protein disulfide isomerase P5; protein disulfide isomerase associated 6; protein disulfide isomerase-related protein; protein disulfide-isomerase A6 precursor; protein disulfide-isomerase A6; thioredoxin domain containing 7; thioredoxin domain-containing protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:286906); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21454685;22673903;7876340", "class_list": "", "function": "May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q641Y3", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:0036498 IRE1-mediated unfolded protein response;GO:0030168 platelet activation;GO:0006457 protein folding;GO:0070527 platelet aggregation;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYI4-1", "uniprot_id": [ { "id": "NHEJ1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYI4", "type": "external" } ], "mass": 33885.0, "length": 304, "protein_name": "Non-homologous end-joining factor 1", "gene_name": "Nhej1", "organism": "Rat", "refseq_name": "non-homologous end-joining factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001014239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014239", "type": "external" } ], "gene_names_uniprotkb": "Nhej1; Xlf", "gene_names_refseq": "Nhej1", "protein_names_uniprotkb": "Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor", "protein_names_refseq": "XRCC4-like factor; non-homologous end-joining factor 1 isoform 1; non-homologous end-joining factor 1; protein cernunnos", "tax_id": 10116, "disease": "severe combined immunodeficiency 124 (Disease Ontology:DOID:0061090)", "pathway": " (rno:363251); (R-RNO-5693571)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21821112;25288157", "class_list": "", "function": "DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary. In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. Alternatively, it has also been shown that rather than forming filaments, a single nhej1 dimer interacts through both head domains with xrcc4 to promote the close alignment of DNA ends. The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other. The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors. Binds DNA in a length-dependent manner., [UniProtKB, UniProtKB, UniProtKB]; Rresults suggest that Caloric Restriction could reduce age-dependent decline of NHEJ activity in various tissues of rats possibly through up-regulation of XRCC4., [RefSeq, PubMed]; These results indicate that the Nhej1 protein is necessary for proper rat cortical development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0070182 DNA polymerase binding;GO:0045027 DNA end binding", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation;GO:0030183 B cell differentiation;GO:0030217 T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYI4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHN2-1", "uniprot_id": [ { "id": "NMD3B_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHN2", "type": "external" } ], "mass": 109158.0, "length": 1002, "protein_name": "Glutamate receptor ionotropic, NMDA 3B", "gene_name": "Grin3b", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 3B precursor", "refseq_ac": [ { "id": "NP_579842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579842", "type": "external" } ], "gene_names_uniprotkb": "Grin3b", "gene_names_refseq": "GluN3B; Grin3b; NMDAR3B; NR3B", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 3B; GluN3B; N-methyl-D-aspartate receptor subtype 3B; NMDAR3B; NR3B", "protein_names_refseq": "N-methyl-D-aspartate receptor subtype 3B; glutamate [NMDA] receptor subunit 3B; glutamate receptor ionotropic, NMDA 3B precursor; glutamate receptor ionotropic, NMDA 3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B; glutamate receptor, ionotropic, NMDA3B", "tax_id": 10116, "disease": "", "pathway": " (rno:170796)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11735224;11823786;18636091;19361480;20813147;20887777", "class_list": "", "function": "Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits. Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine. Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits, [RefSeq, PubMed]; In contrast to NR2D, NR3B expression rises gradually from postnatal day P2 to P21., [RefSeq, PubMed]; NMDA receptor subunit NR3B is essential for the dominant negative properties of calcium moblization into mitochondria., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]; The NMDAR3b subunits exhibit developmental loss around the time of eye opening in rat suprachiasmatic nucleus., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0030594 neurotransmitter receptor activity;GO:0005261 monoatomic cation channel activity;GO:0016594 glycine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0048167 regulation of synaptic plasticity;GO:0051924 regulation of calcium ion transport;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VHN2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497B0-1", "uniprot_id": [ { "id": "NIT2_RAT", "url": "https://www.uniprot.org/uniprot/Q497B0", "type": "external" } ], "mass": 30701.0, "length": 276, "protein_name": "Omega-amidase NIT2", "gene_name": "Nit2", "organism": "Rat", "refseq_name": "omega-amidase NIT2", "refseq_ac": [ { "id": "NP_001029298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029298", "type": "external" } ], "gene_names_uniprotkb": "Nit2", "gene_names_refseq": "Nit2; RGD1310494", "protein_names_uniprotkb": "Omega-amidase NIT2; 3.5.1.3; Nitrilase homolog 2", "protein_names_refseq": "Nit protein 2; nitrilase homolog 2; omega-amidase NIT2", "tax_id": 10116, "disease": "", "pathway": " (rno:288174); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19464248;19595734;34502162", "class_list": "", "function": "Data report that rat liver Nit2 is omega-amidase and in vivo amidase substrates are alpha-ketoglutaramate and alpha-ketosuccinamate, generated by transamination of glutamine and asparagine, respectively., [RefSeq, PubMed]; Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0050152 omega-amidase activity;GO:0106008 2-oxoglutaramate amidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006528 asparagine metabolic process;GO:0006107 oxaloacetate metabolic process;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q497B0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H99-1", "uniprot_id": [ { "id": "NOL10_RAT", "url": "https://www.uniprot.org/uniprot/Q66H99", "type": "external" } ], "mass": 80238.0, "length": 688, "protein_name": "Nucleolar protein 10", "gene_name": "Nol10", "organism": "Rat", "refseq_name": "nucleolar protein 10", "refseq_ac": [ { "id": "NP_001014098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014098", "type": "external" } ], "gene_names_uniprotkb": "Nol10", "gene_names_refseq": "Nol10", "protein_names_uniprotkb": "Nucleolar protein 10", "protein_names_refseq": "nucleolar protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:313981)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF3-1", "uniprot_id": [ { "id": "NDUS4_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF3", "type": "external" } ], "mass": 19741.0, "length": 175, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "gene_name": "Ndufs4", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001020317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020317", "type": "external" } ], "gene_names_uniprotkb": "Ndufs4", "gene_names_refseq": "Aqdq; Ndufs4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-18 kDa; Complex I-18 kDa; NADH-ubiquinone oxidoreductase 18 kDa subunit", "protein_names_refseq": "CI-18 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit; complex I-18 kDa", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 1 (Disease Ontology:DOID:0112074); Leigh disease (Disease Ontology:DOID:3652); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:499529); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "26446791;27213235", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L111", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0003016 respiratory system process;GO:0006954 inflammatory response;GO:0030534 adult behavior;GO:0045087 innate immune response;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XIF3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JA8-1", "uniprot_id": [ { "id": "NGB_RAT", "url": "https://www.uniprot.org/uniprot/Q99JA8", "type": "external" } ], "mass": 16981.0, "length": 151, "protein_name": "Neuroglobin", "gene_name": "Ngb", "organism": "Rat", "refseq_name": "neuroglobin", "refseq_ac": [ { "id": "NP_203523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203523", "type": "external" } ], "gene_names_uniprotkb": "Ngb", "gene_names_refseq": "Glnh; Ngb", "protein_names_uniprotkb": "Neuroglobin; 1.7.-.-; Nitrite reductase", "protein_names_refseq": "globin h; neuroglobin; nitrite reductase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); retinal ischemia (Disease Ontology:DOID:12510); transient cerebral ischemia (Disease Ontology:DOID:224); encephalitis (Disease Ontology:DOID:9588)", "pathway": " (rno:85382); (R-RNO-8981607)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11725647;11820779;12621155;15193759;28829495;29802248;32205448;35818200;36884214", "class_list": "", "function": "A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning., [RefSeq, PubMed]; Acts as an endogenous neuroprotective factor in focal cerebral ischemia, [RefSeq, PubMed]; Cerebral hemorrhage significantly inhibited the spatial learning and memory ability of rats; the mechanism may be related to decreased cerebral expression of BDNF and NGB, [RefSeq, PubMed]; Examination of the cell type-specific expression of neuroglobin in neurons and astroglial cells in primary cultures of rat fetal hippocampal cells finds neuroglobin is only expressed in neurons., [RefSeq, PubMed]; Expression Pattern of Ngb in Astrocytes after Spinal Cord Injury and the Clinical Significance. Publication Status: Online-Only, [RefSeq, PubMed]; Monomeric globin with a bis-histidyl six-coordinate heme-iron atom through which it can bind dioxygen, carbon monoxide and nitric oxide. Could help transport oxygen and increase its availability to the metabolically active neuronal tissues, though its low quantity in tissues as well as its high affinity for dioxygen, which may limit its oxygen-releasing ability, argue against it. The ferrous/deoxygenated form exhibits a nitrite reductase activity and it could produce nitric oxide which in turn inhibits cellular respiration in response to hypoxia. In its ferrous/deoxygenated state, it may also exhibit GDI (Guanine nucleotide Dissociation Inhibitor) activity toward heterotrimeric G-alpha proteins, thereby regulating signal transduction to facilitate neuroprotective responses in the wake of hypoxia and associated oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NGB mRNA and protein are abundantly expressed and widely distributed throughout the adult rat brain, as seen in the NGB-immunopositive signals of neuronal cell bodies and processes., [RefSeq, PubMed]; Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?, [RefSeq, PubMed]; Ngb upregulation in CA1 after hypoxic postconditioning maintained the membranous level of Atp1b1 through Ngb-Atp1b1 interaction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VH38;Q99N62", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0005092 GDP-dissociation inhibitor activity;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043204 perikaryon", "go_biological_process": "GO:0031175 neuron projection development;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0043085 positive regulation of catalytic activity;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q99JA8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XQN1-1", "uniprot_id": [ { "id": "PNCB_RAT", "url": "https://www.uniprot.org/uniprot/Q6XQN1", "type": "external" } ], "mass": 58565.0, "length": 538, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "organism": "Rat", "refseq_name": "nicotinate phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_997492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997492", "type": "external" } ], "gene_names_uniprotkb": "Naprt; Naprt1", "gene_names_refseq": "Naprt1; Naprt", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; NAPRTase; Nicotinate phosphoribosyltransferase domain-containing protein 1", "protein_names_refseq": "NAPRTase; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinate phosphoribosyltransferase-like protein; nicotinate phosphoribosyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:315085); (R-RNO-196807); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17604275;29393594", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009435 NAD+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6XQN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99ML5-1", "uniprot_id": [ { "id": "PCYOX_RAT", "url": "https://www.uniprot.org/uniprot/Q99ML5", "type": "external" } ], "mass": 56288.0, "length": 504, "protein_name": "Prenylcysteine oxidase 1", "gene_name": "Pcyox1", "organism": "Rat", "refseq_name": "prenylcysteine oxidase 1 precursor", "refseq_ac": [ { "id": "NP_659553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659553", "type": "external" } ], "gene_names_uniprotkb": "Pcyox1; Clp55", "gene_names_refseq": "Clp55; Pcyox1", "protein_names_uniprotkb": "Prenylcysteine oxidase 1; 1.8.3.5; Chloride ion pump-associated 55 kDa protein", "protein_names_refseq": "chloride ion pump-associated 55 kDa protein; prenylcysteine oxidase 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:246302)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11716481;24090084;29393594", "class_list": "", "function": "Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0001735 prenylcysteine oxidase activity;GO:0102149 farnesylcysteine lyase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0034361 very-low-density lipoprotein particle", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0030328 prenylcysteine catabolic process;GO:0030327 prenylated protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q99ML5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI55-1", "uniprot_id": [ { "id": "NGLY1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI55", "type": "external" } ], "mass": 74677.0, "length": 651, "protein_name": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "gene_name": "Ngly1", "organism": "Rat", "refseq_name": "peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform 1", "refseq_ac": [ { "id": "NP_001014158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014158", "type": "external" } ], "gene_names_uniprotkb": "Ngly1", "gene_names_refseq": "Ngly1", "protein_names_uniprotkb": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; 3.5.1.52; N-glycanase 1; PNGase; Peptide:N-glycanase", "protein_names_refseq": "PNGase; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform 1; peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; peptide:N-glycanase", "tax_id": 10116, "disease": "congenital disorder of deglycosylation 1 (Disease Ontology:DOID:0060728); congenital disorder of deglycosylation (Disease Ontology:DOID:0060991)", "pathway": " (rno:361014); (R-RNO-532668)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;32259258", "class_list": "", "function": "Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems., [RefSeq, PubMed]; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" } ], "go_molecular_function": "GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XI55-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP47-1", "uniprot_id": [ { "id": "HNRPQ_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP47", "type": "external" } ], "mass": 59710.0, "length": 533, "protein_name": "Heterogeneous nuclear ribonucleoprotein Q", "gene_name": "Syncrip", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein Q isoform 1", "refseq_ac": [ { "id": "NP_001041381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041381", "type": "external" } ], "gene_names_uniprotkb": "Syncrip; Ab2-339; Hnrpq", "gene_names_refseq": "Ab2-339; Syncrip; hnRNP Q", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein Q; Liver regeneration-related protein LRRG077; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; hnRNP Q", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein Q isoform 1; heterogeneous nuclear ribonucleoprotein Q; hnRNP-Q; liver regeneration-related protein LRRG077", "tax_id": 10116, "disease": "", "pathway": " (rno:363113)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15475564;23918799;27771350;34502162", "class_list": "", "function": "Both SYNCRIP (and SYT7) were expressed and partially co-localized in somata of Purkinje neurons in the cerebellar cortex., [RefSeq, PubMed]; Data indicate that atg7, RhoA and hnRNP-Q1 are involved in autophagy negatively regulates early axon growth in cortical neurons., [RefSeq, PubMed]; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Is associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Binds to apoB mRNA AU-rich sequences. Part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. May be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins (By similarity)., [UniProtKB]; SYNCRIP is transported within the dendrite as a component of mRNA granules, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0048027 mRNA 5'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TP47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYH1-1", "uniprot_id": [ { "id": "MPP4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYH1", "type": "external" } ], "mass": 50052.0, "length": 441, "protein_name": "MAGUK p55 subfamily member 4", "gene_name": "Mpp4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mpp4; Dlg6", "gene_names_refseq": "", "protein_names_uniprotkb": "MAGUK p55 subfamily member 4; Discs large homolog 6; rDLG6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:58808)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10558890", "class_list": "", "function": "May play a role in retinal photoreceptors development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYG9;Q9QYH0", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045178 basal part of cell", "go_biological_process": "GO:0035418 protein localization to synapse", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62919-1", "uniprot_id": [ { "id": "NELL1_RAT", "url": "https://www.uniprot.org/uniprot/Q62919", "type": "external" } ], "mass": 89344.0, "length": 810, "protein_name": "Protein kinase C-binding protein NELL1", "gene_name": "Nell1", "organism": "Rat", "refseq_name": "protein kinase C-binding protein NELL1 precursor", "refseq_ac": [ { "id": "NP_112331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112331", "type": "external" } ], "gene_names_uniprotkb": "Nell1", "gene_names_refseq": "Nell1", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL1; NEL-like protein 1", "protein_names_refseq": "NEL-like 1; NEL-like protein 1; protein kinase C-binding protein NELL1 precursor; protein kinase C-binding protein NELL1", "tax_id": 10116, "disease": "craniosynostosis (Disease Ontology:DOID:2340)", "pathway": " (rno:81733)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10548494;12235118;14672347;16243593;23083222;25376942;26772960;30937700;30979495", "class_list": "", "function": "Data show that Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure Erratum:[J Clin Invest 2002 Nov;110(10):1573], [RefSeq, PubMed]; Establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis, [RefSeq, PubMed]; NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration., [RefSeq, PubMed]; Nell-1 overexpression disrupts these pathways resulting in craniofacial anomalies such as premature suture closure., [RefSeq, PubMed]; Nell1 accelerates chondrocyte hypertrophy and endochondral bone formation., [RefSeq, PubMed]; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The expression levels of neural markers were increased in rat pulp and in cultured human dental pulp stem cells stimulated with Nell-1 protein. This is the first study to demonstrate the effect of Nell-1 on dental pulp cells neural-like differentiation., [RefSeq, PubMed]; These findings suggested that combined use of NELL-1 and BMP2 could positively regulate pulp repair., [RefSeq, PubMed]; Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "A6JBG8;D4A284", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0030501 positive regulation of bone mineralization;GO:0045669 positive regulation of osteoblast differentiation;GO:0042177 negative regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q62919-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68EJ0-1", "uniprot_id": [ { "id": "NB5R4_RAT", "url": "https://www.uniprot.org/uniprot/Q68EJ0", "type": "external" } ], "mass": 58835.0, "length": 520, "protein_name": "Cytochrome b5 reductase 4", "gene_name": "Cyb5r4", "organism": "Rat", "refseq_name": "cytochrome b5 reductase 4", "refseq_ac": [ { "id": "NP_596918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596918", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r4; Ncb5or", "gene_names_refseq": "Cyb5r4; Ncb5or; b5&b5R; b5+b5R; cb5/cb5R", "protein_names_uniprotkb": "Cytochrome b5 reductase 4; 1.6.2.2; Flavohemoprotein b5/b5R; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; b5+b5R; cb5/cb5R", "protein_names_refseq": "N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; cytochrome b5 reductase 4; flavohemoprotein b5+b5R; flavohemoprotein b5/b5R", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:171015); (R-RNO-1237044)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11913972;14962668;16216070", "class_list": "", "function": "G179 was required for both effective NADH/NADPH selectivity & to maintain the correct orientation & position of the conserved cysteine in the proline-rich 'CGpppM' motif that is critical for optimum NADH binding & efficient hydride transfer in cb5r., [RefSeq, PubMed]; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6VXY2;Q6VXY3;Q9EPZ4", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0042593 glucose homeostasis;GO:0046677 response to antibiotic;GO:0072593 reactive oxygen species metabolic process;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68EJ0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7D6-1", "uniprot_id": [ { "id": "NIF3L_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7D6", "type": "external" } ], "mass": 41519.0, "length": 376, "protein_name": "NIF3-like protein 1", "gene_name": "Nif3l1", "organism": "Rat", "refseq_name": "NIF3-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001380617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380617", "type": "external" } ], "gene_names_uniprotkb": "Nif3l1", "gene_names_refseq": "Nif3l1", "protein_names_uniprotkb": "NIF3-like protein 1", "protein_names_refseq": "GTP cyclohydrolase I; NIF3 NGG1 interacting factor 3-like 1; NIF3-like protein 1 isoform 1; NIF3-like protein 1; Ngg1 interacting factor 3-like 1; putative GTP cyclohydrolase 1 type 2 Nif3l1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12522100", "class_list": "", "function": "May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7D6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63689-1", "uniprot_id": [ { "id": "NDF2_RAT", "url": "https://www.uniprot.org/uniprot/Q63689", "type": "external" } ], "mass": 41466.0, "length": 382, "protein_name": "Neurogenic differentiation factor 2", "gene_name": "Neurod2", "organism": "Rat", "refseq_name": "neurogenic differentiation factor 2", "refseq_ac": [ { "id": "NP_062199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062199", "type": "external" } ], "gene_names_uniprotkb": "Neurod2", "gene_names_refseq": "Neurod2", "protein_names_uniprotkb": "Neurogenic differentiation factor 2; Brain bHLH protein KW8; NeuroD2", "protein_names_refseq": "brain bHLH protein KW8; neurogenic differentiation 2; neurogenic differentiation factor 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 72 (Disease Ontology:DOID:0112208); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:54276)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15009660;20346398;27146976;28324065;8605021", "class_list": "", "function": "A NeuroD family member binding to an additional motif near the Glucocorticoid receptor response element seems to drive specificity for Mineralocorticoid receptor over glucocorticoid receptor binding at hippocampal binding sites., [RefSeq, PubMed]; Our results reveal an important function for NeuroD2 in balancing synaptic neurotransmission and intrinsic excitability and offer insight into how these processes are coordinated during cortical development., [RefSeq, PubMed]; The transduction pathway by which oleic acid induces the expression of genes responsible for neuronal differentiation appears to be mediated by the transcription factor NeuroD2, a regulator of terminal neuronal differentiation, [RefSeq, PubMed]; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008306 associative learning;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63689-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63789-1", "uniprot_id": [ { "id": "P55G_RAT", "url": "https://www.uniprot.org/uniprot/Q63789", "type": "external" } ], "mass": 54254.0, "length": 461, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "Pik3r3", "organism": "Rat", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1", "refseq_ac": [ { "id": "NP_071549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071549", "type": "external" } ], "gene_names_uniprotkb": "Pik3r3", "gene_names_refseq": "Pik3r3", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK", "protein_names_refseq": "PI3-kinase p85 subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; p55PIK; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase p55 subunit; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); ptdIns-3-kinase p85-gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma", "tax_id": 10116, "disease": "colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:60664); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-1660499); (R-RNO-389357); (R-RNO-416476); (R-RNO-512988); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-9009391); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-912526); (R-RNO-912631); (R-RNO-9927354)", "pathway_count": 17, "publication_count": 2, "publication_id_list": "25388664;8621382", "class_list": "", "function": "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Western blot and mRNA analyses showed that p55gamma expression declined in balloon-injured carotid arteries., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005942 phosphatidylinositol 3-kinase complex;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0008286 insulin receptor signaling pathway;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002042 cell migration involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63789-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIL9-1", "uniprot_id": [ { "id": "NBN_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIL9", "type": "external" } ], "mass": 83150.0, "length": 750, "protein_name": "Nibrin", "gene_name": "Nbn", "organism": "Rat", "refseq_name": "nibrin", "refseq_ac": [ { "id": "NP_620228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620228", "type": "external" } ], "gene_names_uniprotkb": "Nbn; Nbs1", "gene_names_refseq": "Nbn; Nbs1", "protein_names_uniprotkb": "Nibrin; Nijmegen breakage syndrome protein 1 homolog", "protein_names_refseq": "nibrin; nijmegen breakage syndrome protein 1 homolog", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); aplastic anemia (Disease Ontology:DOID:12449); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); ovarian cancer (Disease Ontology:DOID:2394); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); Nijmegen breakage syndrome (Disease Ontology:DOID:7400); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:85482); (R-RNO-2559586); (R-RNO-5685938); (R-RNO-5685939); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693548); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "10908350;22673903;38372104", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination. Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites. Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage. Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions. Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection. RBBP8/CtIP specifically promotes the endonuclease activity of the MRN complex to clear DNA ends containing protein adducts. The MRN complex is also required for the processing of R-loops. NBN also functions in telomere length maintenance via its interaction with TERF2: interaction with TERF2 during G1 phase preventing recruitment of DCLRE1B/Apollo to telomeres. NBN also promotes DNA repair choice at dysfunctional telomeres: NBN phosphorylation by CK2 promotes non-homologous end joining repair at telomeres, while unphosphorylated NBN promotes microhomology-mediated end-joining (MMEJ) repair. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Effect of silencing SSB1 gene on the expression of NBS1 in irradiated rat submandibular gland cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKL2", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0042393 histone binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140031 phosphorylation-dependent protein binding;GO:0140463 chromatin-protein adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016605 PML body;GO:0035861 site of double-strand break", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0043247 telomere maintenance in response to DNA damage;GO:0001701 in utero embryonic development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIL9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UVM4-1", "uniprot_id": [ { "id": "KCNT2_RAT", "url": "https://www.uniprot.org/uniprot/Q6UVM4", "type": "external" } ], "mass": 131100.0, "length": 1142, "protein_name": "Potassium channel subfamily T member 2", "gene_name": "Kcnt2", "organism": "Rat", "refseq_name": "potassium channel subfamily T member 2", "refseq_ac": [ { "id": "NP_942057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942057", "type": "external" } ], "gene_names_uniprotkb": "Kcnt2; Slick", "gene_names_refseq": "Kcnt2; Slick", "protein_names_uniprotkb": "Potassium channel subfamily T member 2; Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1", "protein_names_refseq": "potassium channel subfamily T member 2; potassium channel, sodium-activated subfamily T, member 2; potassium channel, subfamily T, member 2; sequence like an intermediate conductance potassium channel subunit; sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium- and chloride-activated ATP-sensitive potassium channel", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 57 (Disease Ontology:DOID:0080284); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:304827)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14684870;15717307;16687497;17699666;18664322;19403831;25347289;26100633;26823461;29069600", "class_list": "", "function": "Cloning and regulation of slick channel activity., [RefSeq, PubMed]; Heteromer formation between Slick and Slack-B requires a specific epitope that is found in the N-terminal domain of Slack-B and that is absent in the Slack-A isoform., [RefSeq, PubMed]; Our data show SLICK expression is predominantly under the control of NFkappaB. Because neuronal NFkappaB activation occurs during stressful stimuli such as hypoxia and injury, our findings suggest that SLICK is a neuroprotective gene., [RefSeq, PubMed]; SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels, [RefSeq, PubMed]; Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume. Publication Status: Online-Only, [RefSeq, PubMed]; Sodium-activated and chloride-activated potassium channel. Produces rapidly activating outward rectifier K(+) currents (PubMed:14684870, PubMed:17699666, PubMed:19403831, PubMed:29069600). Contributes to regulate neuronal excitability (PubMed:29069600)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; We conclude that Slack and Slick K(Na) channels are required for depolarizing afterpotential of medium diameter rat dorsal root ganglion neurons, [RefSeq, PubMed]; We report the localization of Slick in the rat central nervous system using in situ and immunohistochemical techniques, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0005524 ATP binding;GO:0005267 potassium channel activity;GO:0005228 intracellular sodium-activated potassium channel activity;GO:0070089 chloride-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport;GO:0097623 potassium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6UVM4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64536-1", "uniprot_id": [ { "id": "PDK2_RAT", "url": "https://www.uniprot.org/uniprot/Q64536", "type": "external" } ], "mass": 46106.0, "length": 407, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial", "gene_name": "Pdk2", "organism": "Rat", "refseq_name": "pyruvate dehydrogenase kinase, isozyme 2", "refseq_ac": [ { "id": "NP_110499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110499", "type": "external" } ], "gene_names_uniprotkb": "Pdk2", "gene_names_refseq": "Pdk2", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; 2.7.11.2; PDH kinase 2; PDK P45; Pyruvate dehydrogenase kinase isoform 2", "protein_names_refseq": "PDH kinase 2; PDK P45; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81530); (R-RNO-204174); (R-RNO-5362517)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11483605;11486000;11978179;12573248;14641018;18387944;22910903;25436986;26446791;26769971;7961963;9405293", "class_list": "", "function": "Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species., [RefSeq, PubMed]; Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the pathogenesis of painful diabetic neuropathy., [RefSeq, PubMed]; The Pdk2 and Pdk1 interaction site was identified with nuclear magnetic resonance and mass spectrometry., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0010565 regulation of ketone metabolic process;GO:0006468 protein phosphorylation;GO:0010906 regulation of glucose metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q64536-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJT6-1", "uniprot_id": [ { "id": "LSG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJT6", "type": "external" } ], "mass": 74403.0, "length": 655, "protein_name": "Large subunit GTPase 1 homolog", "gene_name": "Lsg1", "organism": "Rat", "refseq_name": "large subunit GTPase 1 homolog", "refseq_ac": [ { "id": "NP_001013439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013439", "type": "external" } ], "gene_names_uniprotkb": "Lsg1", "gene_names_refseq": "Lsg1; RGD1309089", "protein_names_uniprotkb": "Large subunit GTPase 1 homolog; 3.6.5.-", "protein_names_refseq": "large subunit GTPase 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a GTPase. May act by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm during the 60S ribosomal subunit maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0015030 Cajal body", "go_biological_process": "GO:0015031 protein transport;GO:0000054 ribosomal subunit export from nucleus;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJT6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EP86-1", "uniprot_id": [ { "id": "NPFF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EP86", "type": "external" } ], "mass": 48324.0, "length": 432, "protein_name": "Neuropeptide FF receptor 1", "gene_name": "Npffr1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Npffr1; Gpr147; Npff1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropeptide FF receptor 1; G protein-coupled receptor 147; RFamide-related peptide receptor OT7T022", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:64107); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11024015;11025660", "class_list": "", "function": "Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EP86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N6-1", "uniprot_id": [ { "id": "IGSF1_RAT", "url": "https://www.uniprot.org/uniprot/Q925N6", "type": "external" } ], "mass": 147293.0, "length": 1320, "protein_name": "Immunoglobulin superfamily member 1", "gene_name": "Igsf1", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 1 precursor", "refseq_ac": [ { "id": "NP_786939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786939", "type": "external" } ], "gene_names_uniprotkb": "Igsf1", "gene_names_refseq": "Igsf1; Inhbp", "protein_names_uniprotkb": "Immunoglobulin superfamily member 1; IgSF1; InhBP; Inhibin-binding protein", "protein_names_refseq": "immunoglobulin superfamily member 1 precursor; inhibin-binding protein", "tax_id": 10116, "disease": "IGSF1 deficiency syndrome (Disease Ontology:DOID:0111140)", "pathway": " (rno:302822)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10875264;11266515;24090084;26163525;28686733", "class_list": "", "function": "Contrary to earlier predictions, neither the murine nor rat IGSF1-2 is secreted from heterologous or homologous cells. In addition, neither protein associates with the plasma membrane. Rather, IGSF1-2 appears to be retained in the endoplasmic reticulum. Publication Status: Online-Only, [RefSeq, PubMed]; High levels of Igsf1 in brain, pituitary and fetal liver. Also expressed in pancreas, heart, skeletal muscle, adrenal gland and testis., [RefSeq, PubMed]; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "A0JPK8;Q925N5", "ec_number_list": [], "go_molecular_function": "GO:0038102 activin receptor antagonist activity;GO:0004888 transmembrane signaling receptor activity;GO:0015026 coreceptor activity;GO:0034711 inhibin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006355 regulation of DNA-templated transcription;GO:0032926 negative regulation of activin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925N6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHY4-1", "uniprot_id": [ { "id": "NAR5_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHY4", "type": "external" } ], "mass": 34201.0, "length": 308, "protein_name": "Ecto-ADP-ribosyltransferase 5", "gene_name": "Art5", "organism": "Rat", "refseq_name": "ecto-ADP-ribosyltransferase 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001013057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013057", "type": "external" } ], "gene_names_uniprotkb": "Art5", "gene_names_refseq": "ARTC5; Art5", "protein_names_uniprotkb": "Ecto-ADP-ribosyltransferase 5; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 5; ARTC5; Mono(ADP-ribosyl)transferase 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5; ecto-ADP-ribosyltransferase 5 isoform 1 precursor; ecto-ADP-ribosyltransferase 5; mono(ADP-ribosyl)transferase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:259167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0003953 NAD+ nucleosidase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XHY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62967-1", "uniprot_id": [ { "id": "MVD1_RAT", "url": "https://www.uniprot.org/uniprot/Q62967", "type": "external" } ], "mass": 43893.0, "length": 401, "protein_name": "Diphosphomevalonate decarboxylase", "gene_name": "Mvd", "organism": "Rat", "refseq_name": "diphosphomevalonate decarboxylase", "refseq_ac": [ { "id": "NP_112324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112324", "type": "external" } ], "gene_names_uniprotkb": "Mvd; Mpd", "gene_names_refseq": "Mvd; Mvpd", "protein_names_uniprotkb": "Diphosphomevalonate decarboxylase; 4.1.1.33; MDDase; Mevalonate (diphospho)decarboxylase; Mevalonate pyrophosphate decarboxylase", "protein_names_refseq": "MDDase; diphosphomevalonate decarboxylase; mevalonate (diphospho) decarboxylase; mevalonate pyrophosphate decarboxylase", "tax_id": 10116, "disease": "porokeratosis (Disease Ontology:DOID:3805)", "pathway": " (rno:81726); (R-RNO-446199); (R-RNO-9969896)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11725955;22673903;26158200;29393594", "class_list": "", "function": "Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that the upregulation of miR-214 and downregulation of MPD transcription in the liver both play a role in the development of hypocholesterolemia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642E5", "ec_number_list": [ { "id": "4.1.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.33", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0030544 Hsp70 protein binding;GO:0004163 diphosphomevalonate decarboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006695 cholesterol biosynthetic process;GO:0009410 response to xenobiotic stimulus;GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0033386 geranylgeranyl diphosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62967-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4JLT5-1", "uniprot_id": [ { "id": "NTCP5_RAT", "url": "https://www.uniprot.org/uniprot/Q4JLT5", "type": "external" } ], "mass": 48076.0, "length": 434, "protein_name": "Sodium/bile acid cotransporter 5", "gene_name": "Slc10a5", "organism": "Rat", "refseq_name": "sodium/bile acid cotransporter 5 precursor", "refseq_ac": [ { "id": "NP_001020451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020451", "type": "external" } ], "gene_names_uniprotkb": "Slc10a5; P5", "gene_names_refseq": "Slc10a5", "protein_names_uniprotkb": "Sodium/bile acid cotransporter 5; Na(+)/bile acid cotransporter 5; Solute carrier family 10 member 5", "protein_names_refseq": "Na(+)/bile acid cotransporter 5; sodium/bile acid cotransporter 5 precursor; sodium/bile acid cotransporter 5; solute carrier family 10 (sodium/bile acid cotransporter family), member 5", "tax_id": 10116, "disease": "", "pathway": " (rno:310230)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17632081", "class_list": "", "function": "Molecular cloning and characterization of SLC10A5 as an orphan carrier with yet non-identified substrates., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4JLT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A27-1", "uniprot_id": [ { "id": "NCBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q56A27", "type": "external" } ], "mass": 91911.0, "length": 790, "protein_name": "Nuclear cap-binding protein subunit 1", "gene_name": "Ncbp1", "organism": "Rat", "refseq_name": "nuclear cap-binding protein subunit 1", "refseq_ac": [ { "id": "NP_001014785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014785", "type": "external" } ], "gene_names_uniprotkb": "Ncbp1; Cbp80", "gene_names_refseq": "Ncbp1", "protein_names_uniprotkb": "Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit", "protein_names_refseq": "80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit; nuclear cap binding protein subunit 1, 80kDa; nuclear cap-binding protein subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298075); (R-RNO-111367); (R-RNO-112382); (R-RNO-113418); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-674695); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73856); (R-RNO-77588); (R-RNO-77595); (R-RNO-975956); (R-RNO-975957); (R-RNO-9770562); (R-RNO-9930044)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003729 mRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0000339 RNA cap binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0016071 mRNA metabolic process;GO:0006406 mRNA export from nucleus;GO:0030307 positive regulation of cell growth;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q56A27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62765-1", "uniprot_id": [ { "id": "NLGN1_RAT", "url": "https://www.uniprot.org/uniprot/Q62765", "type": "external" } ], "mass": 94294.0, "length": 843, "protein_name": "Neuroligin-1", "gene_name": "Nlgn1", "organism": "Rat", "refseq_name": "neuroligin-1 precursor", "refseq_ac": [ { "id": "NP_446320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446320", "type": "external" } ], "gene_names_uniprotkb": "Nlgn1", "gene_names_refseq": "Nlgn1", "protein_names_uniprotkb": "Neuroligin-1; Neuroligin I", "protein_names_refseq": "neuroligin I; neuroligin-1 precursor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:116647); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11329178;14769026;15458844;15620359;18093522;18334216;18434543;18755801;19914352;20624592;30790215;32915137;34353896;37865312;7736595;8576240;9325340;9694864;9927700", "class_list": "", "function": "Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity. Publication Status: Online-Only, [RefSeq, PubMed]; Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis., [RefSeq, PubMed]; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (By similarity). The protein is involved in nervous system development., [UniProtKB, PubMed, UniProtKB, PubMed]; Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 1827, "biomarker_type": "", "glycan_count": 60, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0072553 terminal button organization;GO:0016080 synaptic vesicle targeting;GO:0048789 cytoskeletal matrix organization at active zone;GO:0097091 synaptic vesicle clustering;GO:0097115 neurexin clustering involved in presynaptic membrane assembly", "synthesized_glycan_count": 0, "hit_score": 8.8, "record_id": "Q62765-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100100000000.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z29-1", "uniprot_id": [ { "id": "NAMPT_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z29", "type": "external" } ], "mass": 55438.0, "length": 491, "protein_name": "Nicotinamide phosphoribosyltransferase", "gene_name": "Nampt", "organism": "Rat", "refseq_name": "nicotinamide phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_808789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808789", "type": "external" } ], "gene_names_uniprotkb": "Nampt; Pbef1", "gene_names_refseq": "Nampt; Pbef1; Pbef", "protein_names_uniprotkb": "Nicotinamide phosphoribosyltransferase; 2.4.2.12; NAmPRTase; Nampt; PBEF; Pre-B-cell colony-enhancing factor 1 homolog; Visfatin", "protein_names_refseq": "NAmPRTase; nicotinamide phosphoribosyltransferase; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1 homolog; visfatin", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); kidney failure (Disease Ontology:DOID:1074); transient cerebral ischemia (Disease Ontology:DOID:224); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:297508); (R-RNO-196807)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12782293;15922301;16901503;34434488;34952398;34967693;35111160;37914064", "class_list": "", "function": "Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression., [UniProtKB, UniProtKB, UniProtKB]; Emodin inhibits NF-kappaB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin., [RefSeq, PubMed]; Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples. Publication Status: Online-Only, [RefSeq, PubMed]; NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway., [RefSeq, PubMed]; Nampt promotes fibroblast extracellular matrix degradation in stress urinary incontinence by inhibiting autophagy., [RefSeq, PubMed]; PBEF is not a cytokine-like secreted protein but an intracellular protein associated with the cell cycle, [RefSeq, PubMed]; Relative visfatin gene expression is not associated with the metabolic syndrome in WOKW rats [Pbef, also called visfatin], [RefSeq, PubMed]; Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2VT47", "ec_number_list": [ { "id": "2.4.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.12", "type": "external" } ], "go_molecular_function": "GO:0047280 nicotinamide phosphoribosyltransferase activity;GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0005125 cytokine activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0001774 microglial cell activation;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q80Z29-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZF1-1", "uniprot_id": [ { "id": "KCJ15_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZF1", "type": "external" } ], "mass": 45908.0, "length": 405, "protein_name": "ATP-sensitive inward rectifier potassium channel 15", "gene_name": "Kcnj15", "organism": "Rat", "refseq_name": "ATP-sensitive inward rectifier potassium channel 15 isoform 1", "refseq_ac": [ { "id": "NP_579855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579855", "type": "external" } ], "gene_names_uniprotkb": "Kcnj15", "gene_names_refseq": "Kcnj15; Kir4.2", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+) channel Kir4.2; Potassium channel, inwardly rectifying subfamily J member 15", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 15 isoform 1; ATP-sensitive inward rectifier potassium channel 15; inward rectifier K(+) channel Kir4.2; potassium channel, inwardly rectifying subfamily J member 15; potassium voltage-gated channel subfamily J member 15", "tax_id": 10116, "disease": "", "pathway": " (rno:170847); (R-RNO-1296041); (R-RNO-997272)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11804844;22566534", "class_list": "", "function": "Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:11804844). The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity)., [UniProtKB, PubMed]; It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91ZF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY12-1", "uniprot_id": [ { "id": "NB5R2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY12", "type": "external" } ], "mass": 31239.0, "length": 276, "protein_name": "NADH-cytochrome b5 reductase 2", "gene_name": "Cyb5r2", "organism": "Rat", "refseq_name": "NADH-cytochrome b5 reductase 2", "refseq_ac": [ { "id": "NP_001014266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014266", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r2", "gene_names_refseq": "Cyb5r2; RGD1308421", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 2; 1.6.2.2; b5R.2", "protein_names_refseq": "NADH-cytochrome b5 reductase 2; b5R.2", "tax_id": 10116, "disease": "methemoglobinemia (Disease Ontology:DOID:10783)", "pathway": " (rno:365345); (R-RNO-1237044)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15709757;35820466", "class_list": "", "function": "Changes in the nature of the side-chain constituents in the conserved residues, such as proline-92 and tyrosine-93, exert considerable influence on the flavin prosthetic group and significantly impact cytochrome B5 reductase turnover., [RefSeq, PubMed]; NADH-Cytochrome B5 reductase 2 suppresses retinal vascular dysfunction through regulation of vascular endothelial growth factor A in diabetic retinopathy., [RefSeq, PubMed]; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY12-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62609-1", "uniprot_id": [ { "id": "NOE1_RAT", "url": "https://www.uniprot.org/uniprot/Q62609", "type": "external" } ], "mass": 55442.0, "length": 485, "protein_name": "Noelin", "gene_name": "Olfm1", "organism": "Rat", "refseq_name": "noelin isoform a precursor", "refseq_ac": [ { "id": "NP_446025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446025", "type": "external" } ], "gene_names_uniprotkb": "Olfm1; D2Sut1e; Noe1; Noel1; Noel", "gene_names_refseq": "D2Sut1e; Noe1; Olfm1", "protein_names_uniprotkb": "Noelin; 1B426B; Neuronal olfactomedin-related ER localized protein; Olfactomedin-1; Pancortin", "protein_names_refseq": "1B426B; neuronal olfactomedin-related ER localized protein; noelin isoform a precursor; noelin; olfactomedin related ER localized protein; pancortin", "tax_id": 10116, "disease": "", "pathway": " (rno:93667)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10.1039/D0MO00044B;22632720;24090084;34106099;38843836;7932877", "class_list": "", "function": "Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q62606;Q62607;Q62608", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62609-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXQ5-1", "uniprot_id": [ { "id": "PDE12_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXQ5", "type": "external" } ], "mass": 67176.0, "length": 608, "protein_name": "2',5'-phosphodiesterase 12", "gene_name": "Pde12", "organism": "Rat", "refseq_name": "2',5'-phosphodiesterase 12", "refseq_ac": [ { "id": "NP_001398637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001398637", "type": "external" } ], "gene_names_uniprotkb": "Pde12", "gene_names_refseq": "2'-PDE; 2-PDE; LRRGT00074; Pde12; RGD1310975", "protein_names_uniprotkb": "2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 3.1.13.4; 3.1.4.-; Mitochondrial deadenylase", "protein_names_refseq": "2',5'-phosphodiesterase 12; mitochondrial deadenylase", "tax_id": 10116, "disease": "", "pathway": " (rno:306231); (R-RNO-8983711)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004527 exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0071359 cellular response to dsRNA;GO:0006397 mRNA processing;GO:0071346 cellular response to type II interferon;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES39-1", "uniprot_id": [ { "id": "NDE1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES39", "type": "external" } ], "mass": 38528.0, "length": 344, "protein_name": "Nuclear distribution protein nudE homolog 1", "gene_name": "Nde1", "organism": "Rat", "refseq_name": "nuclear distribution protein nudE homolog 1", "refseq_ac": [ { "id": "NP_445799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445799", "type": "external" } ], "gene_names_uniprotkb": "Nde1; Nude1; Nude", "gene_names_refseq": "Nde1; Nude", "protein_names_uniprotkb": "Nuclear distribution protein nudE homolog 1; NudE; rNudE", "protein_names_refseq": "LIS1-interacting protein NUDE1; nuclear distribution gene E homolog 1; nuclear distribution protein nudE homolog 1-like; nuclear distribution protein nudE homolog 1; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; rNudE", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 4 (Disease Ontology:DOID:0112235); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933)", "pathway": " (rno:83836); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9648025)", "pathway_count": 15, "publication_count": 3, "publication_id_list": "10940388;21911489;27553190", "class_list": "", "function": "Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin., [RefSeq, PubMed]; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network., [UniProtKB, UniProtKB]; The severity of NDE1-associated microcephaly results not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642F3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0045202 synapse;GO:0005871 kinesin complex", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0030900 forebrain development;GO:0051301 cell division;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ES39-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64627-1", "uniprot_id": [ { "id": "NEUR2_RAT", "url": "https://www.uniprot.org/uniprot/Q64627", "type": "external" } ], "mass": 42382.0, "length": 379, "protein_name": "Sialidase-2", "gene_name": "Neu2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Neu2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sialidase-2; 3.2.1.18; Cytosolic sialidase; N-acetyl-alpha-neuraminidase 2; Neuraminidase-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-4085001); (R-RNO-9840310)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8253770;8563137", "class_list": "glycogene;glycosylhydrolase", "function": "Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63705", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" } ], "go_molecular_function": "GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:1902494 catalytic complex", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006689 ganglioside catabolic process;GO:0045471 response to ethanol;GO:0045663 positive regulation of myoblast differentiation;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64627-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFW2-1", "uniprot_id": [ { "id": "K1C40_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFW2", "type": "external" } ], "mass": 48296.0, "length": 431, "protein_name": "Keratin, type I cytoskeletal 40", "gene_name": "Krt40", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 40", "refseq_ac": [ { "id": "NP_001008821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008821", "type": "external" } ], "gene_names_uniprotkb": "Krt40; Ka36", "gene_names_refseq": "Ka36; Krt40", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 40; CK-40; Cytokeratin-40; K40; Keratin-40; Type I hair keratin Ka36", "protein_names_refseq": "CK-40; K40; cytokeratin-40; keratin 40, type I; keratin, type I cytoskeletal 40; type I hair keratin KA36", "tax_id": 10116, "disease": "", "pathway": " (rno:287679); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "May play a role in late hair differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62792-1", "uniprot_id": [ { "id": "NRF1_RAT", "url": "https://www.uniprot.org/uniprot/Q62792", "type": "external" } ], "mass": 5339.0, "length": 52, "protein_name": "Nuclear respiratory factor 1", "gene_name": "Nrf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nrf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear respiratory factor 1; Alpha palindromic-binding protein; Alpha-pal; NRF-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:312195)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7629110", "class_list": "", "function": "Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007584 response to nutrient;GO:0032496 response to lipopolysaccharide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62792-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWJ9-1", "uniprot_id": [ { "id": "NRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QWJ9", "type": "external" } ], "mass": 103082.0, "length": 922, "protein_name": "Neuropilin-1", "gene_name": "Nrp1", "organism": "Rat", "refseq_name": "neuropilin-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566", "type": "external" } ], "gene_names_uniprotkb": "Nrp1", "gene_names_refseq": "Nrp1; Nrp", "protein_names_uniprotkb": "Neuropilin-1; Vascular endothelial cell growth factor 165 receptor", "protein_names_refseq": "neuropilin-1 isoform 1 precursor; vascular endothelial cell growth factor 165 receptor", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); retinal vein occlusion (Disease Ontology:DOID:1727); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:246331); (R-RNO-194306); (R-RNO-399954); (R-RNO-399955); (R-RNO-399956); (R-RNO-445144)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "17405859;28270793;33675584;37366599;38843836;9288754", "class_list": "", "function": "Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor kappaB p65 signaling., [RefSeq, PubMed]; Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0097491 sympathetic neuron projection guidance;GO:0097475 motor neuron migration;GO:0001525 angiogenesis;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QWJ9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHC2-1", "uniprot_id": [ { "id": "INT11_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHC2", "type": "external" } ], "mass": 67841.0, "length": 600, "protein_name": "Integrator complex subunit 11", "gene_name": "Ints11", "organism": "Rat", "refseq_name": "integrator complex subunit 11", "refseq_ac": [ { "id": "NP_001029064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029064", "type": "external" } ], "gene_names_uniprotkb": "Ints11; Cpsf3l", "gene_names_refseq": "Cpsf3l; Ints11; int11", "protein_names_uniprotkb": "Integrator complex subunit 11; 3.1.27.-; CPSF3-like protein; Cleavage and polyadenylation-specific factor 3-like protein; Int11", "protein_names_refseq": "CPSF3-like protein; cleavage and polyadenylation specific factor 3-like; cleavage and polyadenylation-specific factor 3-like protein; integrator complex subunit 11", "tax_id": 10116, "disease": "neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities (Disease Ontology:DOID:0081387)", "pathway": " (rno:298688); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA endonuclease component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS11 constitutes the RNA endonuclease subunit that degrades exiting nascent RNA transcripts. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032039 integrator complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MHC2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY62-1", "uniprot_id": [ { "id": "NEUFC_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY62", "type": "external" } ], "mass": 29065.0, "length": 263, "protein_name": "Neuferricin", "gene_name": "Cyb5d2", "organism": "Rat", "refseq_name": "neuferricin precursor", "refseq_ac": [ { "id": "NP_001007672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007672", "type": "external" } ], "gene_names_uniprotkb": "Cyb5d2", "gene_names_refseq": "Cyb5d2", "protein_names_uniprotkb": "Neuferricin; Cytochrome b5 domain-containing protein 2", "protein_names_refseq": "cytochrome b5 domain-containing protein 2; neuferricin precursor; neuferricin", "tax_id": 10116, "disease": "", "pathway": " (rno:303293)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Heme-binding protein which promotes neuronal but not astrocyte differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD2-1", "uniprot_id": [ { "id": "KLH36_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD2", "type": "external" } ], "mass": 69935.0, "length": 613, "protein_name": "Kelch-like protein 36", "gene_name": "Klhl36", "organism": "Rat", "refseq_name": "kelch-like protein 36", "refseq_ac": [ { "id": "NP_001017511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017511", "type": "external" } ], "gene_names_uniprotkb": "Klhl36", "gene_names_refseq": "Klhl36", "protein_names_uniprotkb": "Kelch-like protein 36", "protein_names_refseq": "kelch-like 36; kelch-like protein 36", "tax_id": 10116, "disease": "", "pathway": " (rno:498957)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZG2-1", "uniprot_id": [ { "id": "IP3KC_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZG2", "type": "external" } ], "mass": 74463.0, "length": 678, "protein_name": "Inositol-trisphosphate 3-kinase C", "gene_name": "Itpkc", "organism": "Rat", "refseq_name": "inositol-trisphosphate 3-kinase C", "refseq_ac": [ { "id": "NP_835195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835195", "type": "external" } ], "gene_names_uniprotkb": "Itpkc; Ip3kc", "gene_names_refseq": "IP3K-C; Itpkc", "protein_names_uniprotkb": "Inositol-trisphosphate 3-kinase C; 2.7.1.127; IP3 3-kinase C; IP3K C; Inositol 1,4,5-trisphosphate 3-kinase C; InsP 3-kinase C", "protein_names_refseq": "IP3 3-kinase C; IP3K C; inositol 1,4,5-trisphosphate 3-kinase C; inositol-trisphosphate 3-kinase C; insP 3-kinase C", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:308451); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12649294;22673903", "class_list": "", "function": "Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:12649294). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.127", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.127", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0071277 cellular response to calcium ion;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZG2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERD9-1", "uniprot_id": [ { "id": "I23O1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERD9", "type": "external" } ], "mass": 45831.0, "length": 407, "protein_name": "Indoleamine 2,3-dioxygenase 1", "gene_name": "Ido1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ido1; Ido; Indo", "gene_names_refseq": "", "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 1; 1.13.11.52; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase", "protein_names_refseq": "", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); chlamydia (Disease Ontology:DOID:11263); dengue disease (Disease Ontology:DOID:12205); toxic shock syndrome (Disease Ontology:DOID:14115); pulmonary tuberculosis (Disease Ontology:DOID:2957); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); eczema herpeticum (Disease Ontology:DOID:9123)", "pathway": " (rno:66029); (R-RNO-71240)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection., [UniProtKB, UniProtKB]; Catalyzes the first and rate limiting step of the catabolism of tryptophan along the kynurenine pathway. Involved in immune regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11", "type": "external" }, { "id": "1.13.11.52", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030485 smooth muscle contractile fiber;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0002666 positive regulation of T cell tolerance induction;GO:0032693 negative regulation of interleukin-10 production;GO:0006954 inflammatory response;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9ERD9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7A9-1", "uniprot_id": [ { "id": "MACA1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7A9", "type": "external" } ], "mass": 53503.0, "length": 468, "protein_name": "Microtubule-associated tyrosine carboxypeptidase 1", "gene_name": "Matcap1; Nol3", "organism": "Rat", "refseq_name": "microtubule-associated tyrosine carboxypeptidase 1", "refseq_ac": [ { "id": "NP_001037757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037757", "type": "external" } ], "gene_names_uniprotkb": "Matcap1; Nol3; Nol3", "gene_names_refseq": "Kiaa0895l; Matcap1; Matcap", "protein_names_uniprotkb": "Microtubule-associated tyrosine carboxypeptidase 1; 3.4.17.17", "protein_names_refseq": "microtubule-associated tyrosine carboxypeptidase 1; microtubule-associated tyrosine carboxypeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:688736); (rno:85383)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.17", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0106423 tubulin-tyrosine carboxypeptidase;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0007420 brain development;GO:0042981 regulation of apoptotic process;GO:0051259 protein complex oligomerization;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923S2-1", "uniprot_id": [ { "id": "PDZ1I_RAT", "url": "https://www.uniprot.org/uniprot/Q923S2", "type": "external" } ], "mass": 12243.0, "length": 114, "protein_name": "PDZK1-interacting protein 1", "gene_name": "Pdzk1ip1", "organism": "Rat", "refseq_name": "PDZK1-interacting protein 1", "refseq_ac": [ { "id": "NP_569085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569085", "type": "external" } ], "gene_names_uniprotkb": "Pdzk1ip1; Map17", "gene_names_refseq": "Dd96; Map17; Pdzk1ip1", "protein_names_uniprotkb": "PDZK1-interacting protein 1; 17 kDa membrane-associated protein", "protein_names_refseq": "17 kDa membrane-associated protein; PDZK1-interacting protein 1; membrane-associated protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:81916)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12812916", "class_list": "", "function": "A membrane protein that induces high-affinity and specific Na-dependent transport of d-mannose and d-glucose in X. laevis oocytes, most likely through stimulation of the capacity of an endogenous transport system of the oocyte., [RefSeq, PubMed]; Auxiliary protein of electrogenic Na(+)-coupled sugar symporter Slc5a2/Sglt1 and SLC5A1/SGLT1 (By similarity). Essential for the transporter activity of SLC5A2/SGLT2 but not SLC5A1/SGLT1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q923S2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYR2-1", "uniprot_id": [ { "id": "NDRG3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYR2", "type": "external" } ], "mass": 41507.0, "length": 375, "protein_name": "Protein NDRG3", "gene_name": "LOC120101769; LOC120101770; LOC134486193; Ndrg3", "organism": "Rat", "refseq_name": "protein NDRG3", "refseq_ac": [ { "id": "NP_001013945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013945", "type": "external" } ], "gene_names_uniprotkb": "LOC120101769; LOC120101770; LOC134486193; Ndrg3; LOC120101770; Ndr3; Ndrg3l1; Ndrg3", "gene_names_refseq": "Ndrg3", "protein_names_uniprotkb": "Protein NDRG3; N-myc downstream-regulated gene 3 protein", "protein_names_refseq": "N-myc downstream regulated 3; N-myc downstream regulated gene 3-like; N-myc downstream-regulated gene 3 protein; protein NDRG3", "tax_id": 10116, "disease": "", "pathway": " (rno:296318)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;27812761;29393594;33247804", "class_list": "", "function": "In the hypoxic response of cerebral ischemia, NDRG3 expression was found to be regulated by let-7f microRNA., [RefSeq, PubMed]; MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0046697 decidualization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AYR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Q3-1", "uniprot_id": [ { "id": "GPR3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1Q3", "type": "external" } ], "mass": 35327.0, "length": 329, "protein_name": "G protein-coupled receptor 3", "gene_name": "Gpr3", "organism": "Rat", "refseq_name": "G-protein coupled receptor 3", "refseq_ac": [ { "id": "NP_714949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714949", "type": "external" } ], "gene_names_uniprotkb": "Gpr3", "gene_names_refseq": "Gpcr3; Gpr3", "protein_names_uniprotkb": "G protein-coupled receptor 3; G protein-coupled receptor R4", "protein_names_refseq": "G protein-coupled receptor R4; G-protein coupled receptor 3", "tax_id": 10116, "disease": "", "pathway": " (rno:266769)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12220620;16229830;17284443;24769160;34871769;7698767", "class_list": "", "function": "Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways (PubMed:17284443). Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand. May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (By similarity). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (PubMed:34871769)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons., [RefSeq, PubMed]; The cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12, [RefSeq, PubMed]; This study demonstrate for the first time that the expression of GPR3 modulates the viability of cultured P7 rat CGNs and mediates an antiapoptotic effect in various apoptosis-inducing models using rat cerebellar granule neurons., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63230", "ec_number_list": [], "go_molecular_function": "GO:0038036 sphingosine-1-phosphate receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:1900194 negative regulation of oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K1Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62763-1", "uniprot_id": [ { "id": "KC1G3_RAT", "url": "https://www.uniprot.org/uniprot/Q62763", "type": "external" } ], "mass": 51429.0, "length": 448, "protein_name": "Casein kinase I isoform gamma-3", "gene_name": "Csnk1g3", "organism": "Rat", "refseq_name": "casein kinase I isoform gamma-3 isoform 1", "refseq_ac": [ { "id": "NP_074046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074046", "type": "external" } ], "gene_names_uniprotkb": "Csnk1g3", "gene_names_refseq": "Csnk1g3", "protein_names_uniprotkb": "Casein kinase I isoform gamma-3; 2.7.11.1; CKI-gamma 3", "protein_names_refseq": "CKI-gamma 3; casein kinase I isoform gamma-3 isoform 1; casein kinase I", "tax_id": 10116, "disease": "", "pathway": " (rno:64823)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;38843836;7759525", "class_list": "", "function": "Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W96-1", "uniprot_id": [ { "id": "ISCA1_RAT", "url": "https://www.uniprot.org/uniprot/Q80W96", "type": "external" } ], "mass": 14149.0, "length": 129, "protein_name": "Iron-sulfur cluster assembly 1 homolog, mitochondrial", "gene_name": "Isca1", "organism": "Rat", "refseq_name": "iron-sulfur cluster assembly 1 homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_853657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853657", "type": "external" } ], "gene_names_uniprotkb": "Isca1; Hbld2", "gene_names_refseq": "Hbld2; Isca1; hIscA", "protein_names_uniprotkb": "Iron-sulfur cluster assembly 1 homolog, mitochondrial; HESB-like domain-containing protein 2; Iron-sulfur assembly protein IscA", "protein_names_refseq": "HESB like domain containing 2; HESB-like domain-containing protein 2; HesB protein; iron-sulfur assembly protein IscA; iron-sulfur cluster assembly 1 homolog, mitochondrial precursor; iron-sulfur cluster assembly 1 homolog, mitochondrial", "tax_id": 10116, "disease": "multiple mitochondrial dysfunctions syndrome 5 (Disease Ontology:DOID:0080274)", "pathway": " (rno:290985); (R-RNO-1362409); (R-RNO-9854311)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15262227;37140997", "class_list": "", "function": "A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes., [RefSeq, PubMed]; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:1990229 iron-sulfur cluster assembly complex;GO:0120510 mitochondrial [4Fe-4S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation;GO:0050886 endocrine process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJM1-1", "uniprot_id": [ { "id": "SR5A3_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJM1", "type": "external" } ], "mass": 38092.0, "length": 330, "protein_name": "Polyprenal reductase", "gene_name": "Srd5a3", "organism": "Rat", "refseq_name": "polyprenal reductase isoform 1", "refseq_ac": [ { "id": "NP_001014012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014012", "type": "external" } ], "gene_names_uniprotkb": "Srd5a3", "gene_names_refseq": "RGD1308828; S5AR 3; Srd5a3", "protein_names_uniprotkb": "Polyprenal reductase; 1.3.1.22; 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; S5AR 3; SR type 3; Steroid 5-alpha-reductase 3", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 3; SR type 3; polyprenal reductase isoform 1; polyprenal reductase; probable polyprenol reductase", "tax_id": 10116, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); Kahrizi syndrome (Disease Ontology:DOID:0050807); congenital disorder of glycosylation Iq (Disease Ontology:DOID:0080568)", "pathway": " (rno:305291); (R-RNO-193048); (R-RNO-446199)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8486680", "class_list": "", "function": "Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT)., [UniProtKB, UniProtKB]; Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZUS5;D4A5U7", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity;GO:0160198 polyprenal reductase activity;GO:0102389 polyprenol reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0016095 polyprenol catabolic process;GO:0043048 dolichyl monophosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56B11-1", "uniprot_id": [ { "id": "PELP1_RAT", "url": "https://www.uniprot.org/uniprot/Q56B11", "type": "external" } ], "mass": 119139.0, "length": 1130, "protein_name": "Proline-, glutamic acid- and leucine-rich protein 1", "gene_name": "Pelp1", "organism": "Rat", "refseq_name": "proline-, glutamic acid- and leucine-rich protein 1", "refseq_ac": [ { "id": "NP_001019441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019441", "type": "external" } ], "gene_names_uniprotkb": "Pelp1; Mnar", "gene_names_refseq": "Pelp1; RGD1306320", "protein_names_uniprotkb": "Proline-, glutamic acid- and leucine-rich protein 1; Modulator of non-genomic activity of estrogen receptor", "protein_names_refseq": "modulator of non-genomic activity of estrogen receptor; modulator of nongenomic activity of estrogen receptor; proline, glutamic acid and leucine rich protein 1; proline-, glutamic acid- and leucine-rich protein 1; proline-, glutamic acid-, leucine-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360552); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16141397;22673903;23436000;24146754", "class_list": "", "function": "Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1., [UniProtKB, UniProtKB]; Estradiol treatment of PDLFCs induced PELP1 protein level compared to untreated cells., [RefSeq, PubMed]; MNAR/PELP1 is expressed in key neural tissues of the rat brain that are known targets of steroid action; its expression is primarily neuronal; and MNAR/PELP1-ir is strongly colocalized in ER-alpha, but not GnRH neurons in rodent brain., [RefSeq, PubMed]; Pelp1 may be a key regulator of proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Erratum:[PLoS One. 2013;8(12). doi:10.1371/annotation/5fa9cfb4-9964-4586-845d-d8205f318d68] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 0, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q3MIE2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000791 euchromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006364 rRNA processing;GO:0071391 cellular response to estrogen stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q56B11-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMF3-1", "uniprot_id": [ { "id": "K2C1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMF3", "type": "external" } ], "mass": 64831.0, "length": 625, "protein_name": "Keratin, type II cytoskeletal 1", "gene_name": "Krt1", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 1", "refseq_ac": [ { "id": "NP_001008802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008802", "type": "external" } ], "gene_names_uniprotkb": "Krt1; Kb1", "gene_names_refseq": "Kb1; Krt1", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 1; CK-1; Cytokeratin-1; K1; Keratin-1; Type-II keratin Kb1", "protein_names_refseq": "CK-1; K1; cytokeratin-1; keratin 1, type II; keratin, type II cytoskeletal 1; type-II keratin Kb1", "tax_id": 10116, "disease": "KRT1-related nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0070550); epidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0070551); keratosis palmoplantaris striata 3 (Disease Ontology:DOID:0081110); epidermolytic hyperkeratosis 1 (Disease Ontology:DOID:0081358); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603)", "pathway": " (rno:300250); (R-RNO-6798695); (R-RNO-6805567); (R-RNO-6809371); (R-RNO-9855719); (R-RNO-9970672)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15085952;22673903;32920982;34502162;38843836;41018975", "class_list": "", "function": "Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion., [RefSeq, PubMed]; Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers with a type I keratin, assembling into keratin intermediate filament networks that provide mechanical strength and structural stability to differentiating epidermal cells. May regulate the activity of kinases such as PKC and SRC by interacting with integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP, acts as a high-affinity receptor for kininogen-1 (HMWK)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L113;Q63115", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030246 carbohydrate binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001533 cornified envelope;GO:0045095 keratin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0031424 keratinization;GO:0061436 establishment of skin barrier;GO:0050728 negative regulation of inflammatory response;GO:0051290 protein heterotetramerization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IMF3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64604-1", "uniprot_id": [ { "id": "PTPRF_RAT", "url": "https://www.uniprot.org/uniprot/Q64604", "type": "external" } ], "mass": 211494.0, "length": 1898, "protein_name": "Receptor-type tyrosine-protein phosphatase F", "gene_name": "Ptprf", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase F isoform 3 precursor", "refseq_ac": [ { "id": "NP_062122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062122", "type": "external" } ], "gene_names_uniprotkb": "Ptprf; Lar", "gene_names_refseq": "LARFN5C; Ptprf", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase F; 3.1.3.48; LAR; Leukocyte common antigen related", "protein_names_refseq": "leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related; receptor-type tyrosine-protein phosphatase F isoform 3 precursor; receptor-type tyrosine-protein phosphatase F", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227); hyperinsulinism (Disease Ontology:DOID:2018); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:360406); (R-RNO-388844); (R-RNO-77387); (R-RNO-8849932)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1918076;28752900;30394599;38843836;8068021", "class_list": "", "function": "In a spinal cord injury model, blocking LAR and PTPalpha receptors promotes oligodendrogenesis., [RefSeq, PubMed]; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one., [UniProtKB]; This study showed that astrocytes aberrantly and progressively expressed PTPsigma and LAR at the site of motor neuron degeneration in Tg ALS model rats with mutant SOD1., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 6, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q4JFJ1;Q63294;Q63295;Q63296", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0005158 insulin receptor binding;GO:0008201 heparin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0060076 excitatory synapse", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0048679 regulation of axon regeneration;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q64604-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQX6-1", "uniprot_id": [ { "id": "PDGFC_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQX6", "type": "external" } ], "mass": 38734.0, "length": 345, "protein_name": "Platelet-derived growth factor C", "gene_name": "Pdgfc", "organism": "Rat", "refseq_name": "platelet-derived growth factor C precursor", "refseq_ac": [ { "id": "NP_112607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112607", "type": "external" } ], "gene_names_uniprotkb": "Pdgfc; Scdgf", "gene_names_refseq": "Pdgfc; SCDGF", "protein_names_uniprotkb": "Platelet-derived growth factor C; Fallotein; PDGF-C; Spinal cord-derived growth factor; VEGF-E; rScdfg", "protein_names_refseq": "PDGF-C; VEGF-E; fallotein; platelet-derived growth factor C precursor; platelet-derived growth factor, C polypeptide; rScdfg; spinal cord-derived growth factor", "tax_id": 10116, "disease": "", "pathway": " (rno:79429); (R-RNO-186797)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11162582;11850188;11912250;15267171;16039137;16612331;18272536;22565577;28338461", "class_list": "", "function": "After experimental liver fibrosis, induced by bile-duct occlusion, miR-29 expression was shown to be reduced, but IGF-I and PDGF-C expression was upregulated, correlating inversely to the miR-29 pattern., [RefSeq, PubMed]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function (By similarity)., [UniProtKB]; Mesenchymal stem cells could inhibit the process of chronic rejection of small intestine transplant. The mechanisms may include the inhibited function of these cells on lymphocyte proliferation, reduced infiltration of macrophages, and reduced expression of transforming growth factor beta1 and platelet-derived growth factor C., [RefSeq, PubMed]; The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8K429", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042803 protein homodimerization activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9EQX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63734-1", "uniprot_id": [ { "id": "KCNC4_RAT", "url": "https://www.uniprot.org/uniprot/Q63734", "type": "external" } ], "mass": 68435.0, "length": 625, "protein_name": "Voltage-gated potassium channel KCNC4", "gene_name": "Kcnc4", "organism": "Rat", "refseq_name": "voltage-gated potassium channel KCNC4 isoform 2", "refseq_ac": [ { "id": "NP_001116248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116248", "type": "external" } ], "gene_names_uniprotkb": "Kcnc4", "gene_names_refseq": "Kcnc4", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC4; Potassium voltage-gated channel subfamily C member 4; Raw3; Voltage-gated potassium channel subunit Kv3.4", "protein_names_refseq": "potassium channel, voltage gated Shaw-related subfamily C, member 4; potassium voltage gated channel, Shaw-related subfamily, member 4; potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (Raw3); raw3; voltage-gated potassium channel KCNC4 isoform 2; voltage-gated potassium channel KCNC4; voltage-gated potassium channel subunit Kv3.4", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (rno:684516); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12592408;1378392;1840526;26039360;33368632", "class_list": "", "function": "Data indicate ubiquitous expression of Kv3.4 potassium channel protein in nociceptors. Erratum:[doi: 10.1523/JNEUROSCI.1594-14.2015], [RefSeq, PubMed]; PKCepsilon associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner., [RefSeq, PubMed]; Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:12592408, PubMed:1378392, PubMed:1840526). The channel displays rapid activation and inactivation kinetics (PubMed:12592408, PubMed:1378392, PubMed:1840526)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0030900 forebrain development;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0021987 cerebral cortex development;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63734-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIN7-1", "uniprot_id": [ { "id": "IMPA2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CIN7", "type": "external" } ], "mass": 31796.0, "length": 290, "protein_name": "Inositol monophosphatase 2", "gene_name": "Impa2", "organism": "Rat", "refseq_name": "inositol monophosphatase 2", "refseq_ac": [ { "id": "NP_757378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_757378", "type": "external" } ], "gene_names_uniprotkb": "Impa2", "gene_names_refseq": "Impa2", "protein_names_uniprotkb": "Inositol monophosphatase 2; 3.1.3.25; IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2", "protein_names_refseq": "IMP 2; IMPase 2; inositol (myo)-1(or 4)-monophosphatase 2; inositol monophosphatase 2; inositol-1(or 4)-monophosphatase 2; myo-inositol monophosphatase A2", "tax_id": 10116, "disease": "bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:282636); (R-RNO-1855183)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008934 inositol monophosphate 1-phosphatase activity;GO:0052834 inositol monophosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0010226 response to lithium ion;GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8CIN7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569B5-1", "uniprot_id": [ { "id": "LRC14_RAT", "url": "https://www.uniprot.org/uniprot/Q569B5", "type": "external" } ], "mass": 54915.0, "length": 493, "protein_name": "Leucine-rich repeat-containing protein 14", "gene_name": "Lrrc14", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 14 isoform 2", "refseq_ac": [ { "id": "NP_001019525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019525", "type": "external" } ], "gene_names_uniprotkb": "Lrrc14", "gene_names_refseq": "Lrrc14", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 14", "protein_names_refseq": "leucine-rich repeat-containing protein 14 isoform 2; leucine-rich repeat-containing protein 14", "tax_id": 10116, "disease": "", "pathway": " (rno:500900); (R-RNO-9758274)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034122 negative regulation of toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569B5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE6-1", "uniprot_id": [ { "id": "MPRIP_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERE6", "type": "external" } ], "mass": 117113.0, "length": 1029, "protein_name": "Myosin phosphatase Rho-interacting protein", "gene_name": "Mprip", "organism": "Rat", "refseq_name": "myosin phosphatase Rho-interacting protein isoform 3", "refseq_ac": [ { "id": "NP_001029194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029194", "type": "external" } ], "gene_names_uniprotkb": "Mprip; Mrip; Rhoip3", "gene_names_refseq": "M-rip; Mprip; Mrip; Rhoip3; p116Rip", "protein_names_uniprotkb": "Myosin phosphatase Rho-interacting protein; RIP3; Rho-interacting protein 3; p116Rip", "protein_names_refseq": "RIP3; Rho interacting protein 3; myosin phosphatase Rho-interacting protein isoform 3; rho-interacting protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:116504)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17661354;22673903;23374330;29393594;34772825;38142589", "class_list": "", "function": "Myosin phosphatase-rho interacting protein is a scaffold linking RhoA to regulate myosin phosphatase at the stress fiber., [RefSeq, PubMed]; RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling., [RefSeq, PubMed]; Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis., [RefSeq, PubMed]; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results indicated that RIP3 is expressed differentially in retinal neurons in adult rats, including subsets of ganglion cells, amacrine and horizontal cells. RIP3 protein levels are elevated rapidly following aHIOP Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM03", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ERE6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VV72-1", "uniprot_id": [ { "id": "IF1A_RAT", "url": "https://www.uniprot.org/uniprot/Q6VV72", "type": "external" } ], "mass": 16502.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 1A", "gene_name": "Eif1a", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 1A", "refseq_ac": [ { "id": "NP_001008773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008773", "type": "external" } ], "gene_names_uniprotkb": "Eif1a; Ab1-287", "gene_names_refseq": "Eif1a", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 1A; Eukaryotic translation initiation factor 4C; Liver regeneration-related protein LRRG048; eIF-1A; eIF-4C", "protein_names_refseq": "Ab1-287; X-linked eukaryotic translation initiation factor 1A; eIF-1A; eIF-4C; eukaryotic translation initiation factor 1A; eukaryotic translation initiation factor 4C; liver regeneration-related protein LRRG048", "tax_id": 10116, "disease": "uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (rno:317163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6VV72-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG02-1", "uniprot_id": [ { "id": "K22E_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG02", "type": "external" } ], "mass": 69127.0, "length": 685, "protein_name": "Keratin, type II cytoskeletal 2 epidermal", "gene_name": "Krt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt2; Kb2; Krt2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 2 epidermal; CK-2e; Cytokeratin-2e; Epithelial keratin-2e; K2e; Keratin-2 epidermis; Keratin-2e; Type-II keratin Kb2", "protein_names_refseq": "", "tax_id": 10116, "disease": "bullous congenital ichthyosiform erythroderma (Disease Ontology:DOID:0060877); ichthyosis (Disease Ontology:DOID:1697)", "pathway": " (rno:406228); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15085952;29393594;38843836", "class_list": "", "function": "Structural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support mechanical integrity and resilience of the differentiating epidermis (By similarity). Contributes to terminal differentiation and cornification of keratinocytes and plays a role in establishing the epidermal barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008092 cytoskeletal protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0032980 keratinocyte activation;GO:0051546 keratinocyte migration;GO:0031424 keratinization;GO:0008544 epidermis development;GO:0003334 keratinocyte development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IG02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJK1-1", "uniprot_id": [ { "id": "GPM6B_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJK1", "type": "external" } ], "mass": 28973.0, "length": 265, "protein_name": "Neuronal membrane glycoprotein M6-b", "gene_name": "Gpm6b", "organism": "Rat", "refseq_name": "neuronal membrane glycoprotein M6-b isoform 2", "refseq_ac": [ { "id": "NP_620201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620201", "type": "external" } ], "gene_names_uniprotkb": "Gpm6b; M6b; rhombex-29", "gene_names_refseq": "Gpm6b; M6b", "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-b; M6b; Rhombencephalic expression protein-29 kDa; Rhombex-29", "protein_names_refseq": "Rhombex-29; neuronal membrane glycoprotein M6-b isoform 2; neuronal membrane glycoprotein M6-b; rhombencephalic expression protein-29 kDa", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:192179)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11002282;18581270;29282769", "class_list": "", "function": "May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake., [UniProtKB]; Study identified glycoprotein M6B as a Schwann cell microvilli component of peripheral nodes of Ranvier. Study detected Na(+) channel clusters at heminodes without any associated M6B, indicating that it is not required for initial channel clustering; showed that absence of M6B results in progressive appearance of nodal protrusions of the nodal axolemma, that are often accompanied by the presence of enlarged mitochondria., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043209 myelin sheath;GO:0045121 membrane raft;GO:0016020 membrane", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0085029 extracellular matrix assembly;GO:0015031 protein transport;GO:0022010 central nervous system myelination;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63511-1", "uniprot_id": [ { "id": "KCNJ9_RAT", "url": "https://www.uniprot.org/uniprot/Q63511", "type": "external" } ], "mass": 43965.0, "length": 393, "protein_name": "G protein-activated inward rectifier potassium channel 3", "gene_name": "Kcnj9", "organism": "Rat", "refseq_name": "G protein-activated inward rectifier potassium channel 3", "refseq_ac": [ { "id": "NP_446286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446286", "type": "external" } ], "gene_names_uniprotkb": "Kcnj9; Girk3", "gene_names_refseq": "Girk3; Kcnj9; Kir3.3", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 3; GIRK-3; Inward rectifier K(+) channel Kir3.3; Potassium channel, inwardly rectifying subfamily J member 9", "protein_names_refseq": "G protein-activated inward rectifier potassium channel 3; GIRK-3; inward rectifier K(+) channel Kir3.3; inwardly rectifier K(+) channel Kir3.3; potassium channel, inwardly rectifying subfamily J member 9; potassium voltage-gated channel subfamily J member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:116560); (R-RNO-1296041); (R-RNO-997272)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17828261;18698588;18755244;20610389;21422294;8670306", "class_list": "", "function": "A decisive role for the neuronal K(+) channel in regulating NCAM-dependent neurite outgrowth and attribute a physiologically meaningful role to the functional interplay of Kir3.3, NCAM, and TrkB in ontogeny, [RefSeq, PubMed]; Data describe localization of GIRK1, GIRK2, and GIRK3 subunits and 5-HT(1A) receptor in rat brain, and their co-expression with markers of glutamatergic, gamma-aminobutyric acid (GABA)ergic, cholinergic, and serotonergic neurons., [RefSeq, PubMed]; The Kir3.3 subunit protein is expressed in raphe-derived axons at the light and electron microscopic level., [RefSeq, PubMed]; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Unable to produce channel activity when expressed alone but forms a functional channel in association with KCNJ3/GIRK1., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane;GO:0099505 regulation of presynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63511-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQL5-1", "uniprot_id": [ { "id": "PTSS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQL5", "type": "external" } ], "mass": 55664.0, "length": 473, "protein_name": "Phosphatidylserine synthase 1", "gene_name": "Ptdss1", "organism": "Rat", "refseq_name": "phosphatidylserine synthase 1", "refseq_ac": [ { "id": "NP_001012113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012113", "type": "external" } ], "gene_names_uniprotkb": "Ptdss1", "gene_names_refseq": "PSS-1; Ptdss1", "protein_names_uniprotkb": "Phosphatidylserine synthase 1; 2.7.8.29; PSS-1; PtdSer synthase 1; Serine-exchange enzyme I", "protein_names_refseq": "phosphatidylserine synthase 1; ptdSer synthase 1; serine-exchange enzyme I", "tax_id": 10116, "disease": "Lenz-Majewski hyperostotic dwarfism (Disease Ontology:DOID:0111507)", "pathway": " (rno:314553); (R-RNO-1483101)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0106258 L-serine-phosphatidylcholine phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQL5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG01-1", "uniprot_id": [ { "id": "K2C1B_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG01", "type": "external" } ], "mass": 57255.0, "length": 519, "protein_name": "Keratin, type II cytoskeletal 1b", "gene_name": "Krt77", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 1b", "refseq_ac": [ { "id": "NP_001008807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008807", "type": "external" } ], "gene_names_uniprotkb": "Krt77; Kb39; Krt1b", "gene_names_refseq": "CK-1B; K77; Kb39; Krt77", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 1b; CK-1B; Cytokeratin-1B; K77; Keratin-77; Type-II keratin Kb39", "protein_names_refseq": "cytokeratin-1B; keratin 77, type II; keratin, type II cytoskeletal 1b; type II keratin Kb39", "tax_id": 10116, "disease": "", "pathway": " (rno:406226); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15085952;38843836", "class_list": "", "function": "Structural component of intermediate filaments in epithelial cells of stratified epithelia. Assembles into heteropolymers with a type I keratin, forming keratin intermediate filament networks contributing to epithelial integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IG01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPH8-1", "uniprot_id": [ { "id": "PABP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPH8", "type": "external" } ], "mass": 70701.0, "length": 636, "protein_name": "Polyadenylate-binding protein 1", "gene_name": "Pabpc1", "organism": "Rat", "refseq_name": "polyadenylate-binding protein 1", "refseq_ac": [ { "id": "NP_599180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599180", "type": "external" } ], "gene_names_uniprotkb": "Pabpc1; Pabp1", "gene_names_refseq": "PABP 1; Pabp1; Pabpc1; Pabp", "protein_names_uniprotkb": "Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1", "protein_names_refseq": "PABP-1; poly(A)-binding protein 1; polyadenylate-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:171350); (R-RNO-156827); (R-RNO-429947); (R-RNO-450408); (R-RNO-72649); (R-RNO-975956); (R-RNO-975957)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "11416190;18683930;29393594;31743794;38843836", "class_list": "", "function": "Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability., [UniProtKB, UniProtKB]; Binds the poly(A) tail of mRNA., [UniProtKB, UniProtKB]; Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030425 dendrite", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EPH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811Q0-1", "uniprot_id": [ { "id": "KCMB2_RAT", "url": "https://www.uniprot.org/uniprot/Q811Q0", "type": "external" } ], "mass": 27154.0, "length": 235, "protein_name": "Calcium-activated potassium channel subunit beta-2", "gene_name": "Kcnmb2", "organism": "Rat", "refseq_name": "calcium-activated potassium channel subunit beta-2", "refseq_ac": [ { "id": "NP_789831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789831", "type": "external" } ], "gene_names_uniprotkb": "Kcnmb2", "gene_names_refseq": "Kcmb2; Kcnmb2", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Rbeta3; Slo-beta-2", "protein_names_refseq": "BK channel subunit beta-2; BKbeta2; calcium-activated potassium channel beta 2; calcium-activated potassium channel subunit beta-2; calcium-activated potassium channel, subfamily M subunit beta-2; charybdotoxin receptor subunit beta-2; k(VCA)beta-2; maxi K channel subunit beta-2; potassium channel subfamily M regulatory beta subunit 2; potassium large conductance calcium-activated channel, subfamily M, beta member 2; rbeta3; slo-beta-2", "tax_id": 10116, "disease": "", "pathway": " (rno:294961); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10377337;12454985;17209121;17523149", "class_list": "", "function": "DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed., [RefSeq, PubMed]; Kcnmb2 is responsible for inactivating large-conductance calcium-dependent potassium currents in small sensory dorsal root ganglion neurons., [RefSeq, PubMed]; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8CF83", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005267 potassium channel activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q811Q0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLM7-1", "uniprot_id": [ { "id": "KIF5A_RAT", "url": "https://www.uniprot.org/uniprot/Q6QLM7", "type": "external" } ], "mass": 116916.0, "length": 1027, "protein_name": "Kinesin heavy chain isoform 5A", "gene_name": "Kif5a", "organism": "Rat", "refseq_name": "kinesin heavy chain isoform 5A", "refseq_ac": [ { "id": "NP_997688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997688", "type": "external" } ], "gene_names_uniprotkb": "Kif5a", "gene_names_refseq": "Kif5a", "protein_names_uniprotkb": "Kinesin heavy chain isoform 5A; 5.6.1.3; Kinesin heavy chain neuron-specific 1; NKHC; Neuronal kinesin heavy chain", "protein_names_refseq": "NKHC; kinesin heavy chain isoform 5A; kinesin heavy chain neuron-specific 1; neuronal kinesin heavy chain", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 25 (Disease Ontology:DOID:0081379); hereditary spastic paraplegia 10 (Disease Ontology:DOID:0110763); prostate cancer (Disease Ontology:DOID:10283); spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); multiple sclerosis (Disease Ontology:DOID:2377); hereditary spastic paraplegia (Disease Ontology:DOID:2476); rheumatoid arthritis (Disease Ontology:DOID:7148); asbestos-related lung carcinoma (Disease Ontology:DOID:7596)", "pathway": " (rno:314906); (R-RNO-2132295); (R-RNO-5625970); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "14600269;23576431;28886967;34348158;36214718;36862119;38843836;7514426;9405049", "class_list": "", "function": "A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression., [RefSeq, PubMed]; HDAC-dependent regulatory circuit that promotes formation of JIP1:KIF5A:microtubule complexes that regulate intracellular transport of cargo such as autophagosomes, is reported., [RefSeq, PubMed]; HIF1alpha protects PC12 cells from OGD/Rinduced cell injury by regulating autophagy flux through the miR20a5p/KIF5A axis., [RefSeq, PubMed]; Kif5a Regulates Mitochondrial Transport in Developing Retinal Ganglion Cells In Vitro., [RefSeq, PubMed]; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0035253 ciliary rootlet", "go_biological_process": "GO:1904647 response to rotenone;GO:0099641 anterograde axonal protein transport;GO:1990090 cellular response to nerve growth factor stimulus;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6QLM7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6F596-1", "uniprot_id": [ { "id": "GGPPS_RAT", "url": "https://www.uniprot.org/uniprot/Q6F596", "type": "external" } ], "mass": 34778.0, "length": 300, "protein_name": "Geranylgeranyl pyrophosphate synthase", "gene_name": "Ggps1", "organism": "Rat", "refseq_name": "geranylgeranyl pyrophosphate synthase", "refseq_ac": [ { "id": "NP_001007627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007627", "type": "external" } ], "gene_names_uniprotkb": "Ggps1", "gene_names_refseq": "Crlf3; Ggps1; rGGPS1a1; rGGPS1a2; rGGPS1a3; rGGPS1a", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.-; 2.5.1.10; 2.5.1.1; 2.5.1.29; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; GGPP synthase; GGPPSase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "(2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPP synthetase; GGPPSase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyltranstransferase; geranylgeranyl pyrophosphate synthase; geranylgeranyl pyrophosphate synthetase; geranyltranstransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:291211); (R-RNO-9969896)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15598886;17846065", "class_list": "", "function": "Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins., [UniProtKB, UniProtKB]; Expression level of rat active GGPS is regulated through the splicing of intron 4b of its gene, [RefSeq, PubMed]; KMFTEENE fragment residing on the carboxyl-terminal sequence of geranylgeranyl diphosphate synthase stabilizes the active region involved in the substrate binding and catalysis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.1", "type": "external" }, { "id": "2.5.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.10", "type": "external" }, { "id": "2.5.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.29", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0006720 isoprenoid metabolic process;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6F596-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62976-1", "uniprot_id": [ { "id": "KCMA1_RAT", "url": "https://www.uniprot.org/uniprot/Q62976", "type": "external" } ], "mass": 134374.0, "length": 1209, "protein_name": "Calcium-activated potassium channel subunit alpha-1", "gene_name": "Kcnma1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnma1; Kcnma", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); paroxysmal nonkinesigenic dyskinesia 3 (Disease Ontology:DOID:0070442); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); alcohol use disorder (Disease Ontology:DOID:1574); generalized epilepsy (Disease Ontology:DOID:1827); substance-related disorder (Disease Ontology:DOID:303)", "pathway": " (rno:83731); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10384881;10651830;11278440;16166559;22673903;9403560", "class_list": "", "function": "Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08626;O55180;O88659;Q7TMZ7;Q7TMZ8;Q7TQ55;Q7TQ56;Q7TQ57;Q9WUI3", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0034465 response to carbon monoxide;GO:0006970 response to osmotic stress;GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62976-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVQ8-1", "uniprot_id": [ { "id": "NLRX1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVQ8", "type": "external" } ], "mass": 107590.0, "length": 973, "protein_name": "NLR family member X1", "gene_name": "Nlrx1", "organism": "Rat", "refseq_name": "NLR family member X1 precursor", "refseq_ac": [ { "id": "NP_001020181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020181", "type": "external" } ], "gene_names_uniprotkb": "Nlrx1", "gene_names_refseq": "Nlrx1; RGD1311293", "protein_names_uniprotkb": "NLR family member X1", "protein_names_refseq": "NLR family member X1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:315599); (R-RNO-936440); (R-RNO-9758274)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "32099552;35259612;36692416", "class_list": "", "function": "Dexmedetomidine Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Rats Through Reducing MicroRNA-134-5p-Mediated NLRX1 Downregulation., [RefSeq, PubMed]; Inhibition of microRNA-15 protects H9c2 cells against CVB3-induced myocardial injury by targeting NLRX1 to regulate the NLRP3 inflammasome. Publication Status: Online-Only, [RefSeq, PubMed]; Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage., [RefSeq, PubMed]; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0032688 negative regulation of interferon-beta production", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5FVQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63679-1", "uniprot_id": [ { "id": "KDM3A_RAT", "url": "https://www.uniprot.org/uniprot/Q63679", "type": "external" } ], "mass": 135404.0, "length": 1214, "protein_name": "Lysine-specific demethylase 3A", "gene_name": "Kdm3a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kdm3a; Jhdm2a; Jmjd1a; Tsga", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 3A; 1.14.11.65; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A; Testis-specific gene A protein; Zinc finger protein TSGA; [histone H3]-dimethyl-L-lysine(9) demethylase 3A", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); colon cancer (Disease Ontology:DOID:219); Ewing sarcoma (Disease Ontology:DOID:3369); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:312440); (R-RNO-3214842)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1793593", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Directly regulates expression of PPARA and UCP1 and is involved in obesity resistance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0046293 formaldehyde biosynthetic process;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63679-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M808-1", "uniprot_id": [ { "id": "HIKES_RAT", "url": "https://www.uniprot.org/uniprot/Q5M808", "type": "external" } ], "mass": 21619.0, "length": 197, "protein_name": "Protein Hikeshi", "gene_name": "Hikeshi", "organism": "Rat", "refseq_name": "protein Hikeshi isoform 2", "refseq_ac": [ { "id": "NP_001013919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013919", "type": "external" } ], "gene_names_uniprotkb": "Hikeshi", "gene_names_refseq": "Hikeshi; l7Rn6", "protein_names_uniprotkb": "Protein Hikeshi", "protein_names_refseq": "Hikeshi, heat shock protein nuclear import factor; lethal, Chr 7, Rinchik 6; protein Hikeshi isoform 2; protein Hikeshi; uncharacterized protein C11orf73 homolog", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 13 (Disease Ontology:DOID:0060795)", "pathway": " (rno:293103); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V889", "ec_number_list": [], "go_molecular_function": "GO:0030544 Hsp70 protein binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0030324 lung development;GO:0034605 cellular response to heat;GO:0007030 Golgi organization;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M808-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFW5-1", "uniprot_id": [ { "id": "K1C12_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFW5", "type": "external" } ], "mass": 48820.0, "length": 456, "protein_name": "Keratin, type I cytoskeletal 12", "gene_name": "Krt12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt12; Ka12; Krt1-12", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 12; CK-12; Cytokeratin-12; K12; Keratin-12; Type I keratin Ka12", "protein_names_refseq": "", "tax_id": 10116, "disease": "Meesmann corneal dystrophy 1 (Disease Ontology:DOID:0080670); corneal dystrophy (Disease Ontology:DOID:2566)", "pathway": " (rno:360625); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15085952;29393594", "class_list": "", "function": "Structural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type II keratin KRT3, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrity to the corneal epithelial layer., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament;GO:0005882 intermediate filament", "go_biological_process": "GO:0060429 epithelium development;GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium;GO:0061303 cornea development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IFW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7C9-1", "uniprot_id": [ { "id": "NKAP_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7C9", "type": "external" } ], "mass": 47267.0, "length": 415, "protein_name": "NF-kappa-B-activating protein", "gene_name": "Nkap", "organism": "Rat", "refseq_name": "NF-kappa-B-activating protein", "refseq_ac": [ { "id": "NP_001020043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020043", "type": "external" } ], "gene_names_uniprotkb": "Nkap", "gene_names_refseq": "2610020o08rik; Nkap", "protein_names_uniprotkb": "NF-kappa-B-activating protein", "protein_names_refseq": "NF-kappa-B-activating protein; nuclear NF-kappaB activating protein", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:298342); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PR0-1", "uniprot_id": [ { "id": "POMT1_RAT", "url": "https://www.uniprot.org/uniprot/Q99PR0", "type": "external" } ], "mass": 85496.0, "length": 747, "protein_name": "Protein O-mannosyl-transferase 1", "gene_name": "Pomt1", "organism": "Rat", "refseq_name": "protein O-mannosyl-transferase 1", "refseq_ac": [ { "id": "NP_445858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445858", "type": "external" } ], "gene_names_uniprotkb": "Pomt1", "gene_names_refseq": "Pomt1", "protein_names_uniprotkb": "Protein O-mannosyl-transferase 1; 2.4.1.109; Dolichyl-phosphate-mannose--protein mannosyltransferase 1", "protein_names_refseq": "dolichyl-phosphate-mannose--protein mannosyltransferase 1; protein O-mannosyl-transferase 1", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2K (Disease Ontology:DOID:0110297); congenital muscular dystrophy-dystroglycanopathy type A1 (Disease Ontology:DOID:0111237); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:84430); (R-RNO-8932504); (R-RNO-8932505); (R-RNO-8932506); (R-RNO-9768727)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "24090084", "class_list": "glycogene;glycosyltransferase", "function": "Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins., [UniProtKB, UniProtKB, UniProtKB]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 188, "biomarker_type": "", "glycan_count": 2, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRI2", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030 mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle;GO:0016529 sarcoplasmic reticulum;GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex", "go_biological_process": "GO:1904100 positive regulation of protein O-linked glycosylation;GO:0030198 extracellular matrix organization;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 1677, "hit_score": 0.5, "record_id": "Q99PR0-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLZ1-1", "uniprot_id": [ { "id": "GLRX3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLZ1", "type": "external" } ], "mass": 37849.0, "length": 337, "protein_name": "Glutaredoxin-3", "gene_name": "Glrx3", "organism": "Rat", "refseq_name": "glutaredoxin-3", "refseq_ac": [ { "id": "NP_116003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116003", "type": "external" } ], "gene_names_uniprotkb": "Glrx3; Picot; Txnl2", "gene_names_refseq": "Glrx3; PICOT; Txnl2", "protein_names_uniprotkb": "Glutaredoxin-3; PICOT; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; Thioredoxin-like protein 2", "protein_names_refseq": "PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; glutaredoxin-3; thioredoxin-like 2; thioredoxin-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:58815)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10636891;16809552;18258855;18479680;29393594", "class_list": "", "function": "Data suggest that PICOT inhibits cardiac hypertrophy largely by negatively regulating calcineurin-NFAT signaling via disruption of the MLP-calcineurin interaction., [RefSeq, PubMed]; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RK11", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0030018 Z disc", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006879 intracellular iron ion homeostasis;GO:0045454 cell redox homeostasis;GO:0002026 regulation of the force of heart contraction;GO:0010614 negative regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JLZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5S6T3-1", "uniprot_id": [ { "id": "ISPD_RAT", "url": "https://www.uniprot.org/uniprot/Q5S6T3", "type": "external" } ], "mass": 49192.0, "length": 447, "protein_name": "D-ribitol-5-phosphate cytidylyltransferase", "gene_name": "Crppa", "organism": "Rat", "refseq_name": "D-ribitol-5-phosphate cytidylyltransferase", "refseq_ac": [ { "id": "NP_001008387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008387", "type": "external" } ], "gene_names_uniprotkb": "Crppa; Ispd; Nip", "gene_names_refseq": "Crppa; Ispd; Nip", "protein_names_uniprotkb": "D-ribitol-5-phosphate cytidylyltransferase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; 2.7.7.40; Isoprenoid synthase domain-containing protein; Notch1-induced protein", "protein_names_refseq": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; D-ribitol-5-phosphate cytidylyltransferase; isoprenoid synthase domain containing; isoprenoid synthase domain-containing protein; notch1-induced protein", "tax_id": 10116, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); autosomal recessive limb-girdle muscular dystrophy type 2U (Disease Ontology:DOID:0110295); congenital muscular dystrophy-dystroglycanopathy type A7 (Disease Ontology:DOID:0111234)", "pathway": " (rno:493574); (R-RNO-9939291)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity)., [UniProtKB, UniProtKB]; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5S6T4", "ec_number_list": [ { "id": "2.7.7.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.40", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity;GO:0070567 cytidylyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0007411 axon guidance;GO:0035269 protein O-linked glycosylation via mannose;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5S6T3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GVH5-1", "uniprot_id": [ { "id": "GGNB2_RAT", "url": "https://www.uniprot.org/uniprot/Q6GVH5", "type": "external" } ], "mass": 79009.0, "length": 696, "protein_name": "Gametogenetin-binding protein 2", "gene_name": "Ggnbp2", "organism": "Rat", "refseq_name": "gametogenetin-binding protein 2", "refseq_ac": [ { "id": "NP_001004273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004273", "type": "external" } ], "gene_names_uniprotkb": "Ggnbp2; Zfp403; Znf403", "gene_names_refseq": "Ggnbp2; Zfp403; Znf403", "protein_names_uniprotkb": "Gametogenetin-binding protein 2; Protein ZNF403", "protein_names_refseq": "gametogenetin-binding protein 2; zinc finger protein 403", "tax_id": 10116, "disease": "", "pathway": " (rno:360584)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642376;22673903", "class_list": "", "function": "May be involved in spermatogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0030154 cell differentiation;GO:0061099 negative regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6GVH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWS8-1", "uniprot_id": [ { "id": "KCNH8_RAT", "url": "https://www.uniprot.org/uniprot/Q9QWS8", "type": "external" } ], "mass": 123231.0, "length": 1102, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH8", "gene_name": "Kcnh8", "organism": "Rat", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH8", "refseq_ac": [ { "id": "NP_659563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659563", "type": "external" } ], "gene_names_uniprotkb": "Kcnh8; Elk1; Elk3", "gene_names_refseq": "ELK3; Elk1; Ets-1; Kcnh8; RELK3", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH8; ELK channel 3; Ether-a-go-go-like potassium channel 3; Potassium voltage-gated channel subfamily H member 8; RELK3; Voltage-gated potassium channel subunit Kv12.1", "protein_names_refseq": "ELK channel 3; ether-a-go-go-like potassium channel 1; ether-a-go-go-like potassium channel 3; potassium channel, voltage gated eag related subfamily H, member 8; potassium voltage-gated channel, subfamily H (eag-related), member 8; voltage-gated delayed rectifier potassium channel KCNH8; voltage-gated potassium channel subunit Kv12.1", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:246325); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10718922;11425889;18650019;9714851;9824707", "class_list": "", "function": "Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents (PubMed:9714851). Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV (PubMed:9714851). Shows no obvious change in the activation rate from different holding potentials (PubMed:9714851). Activation is strongly dependent on the pH of the external solution (PubMed:9714851)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The results indicate that Eag1 protein expression greatly overlaps with mRNA distribution in rat., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88877", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0043066 negative regulation of apoptotic process;GO:0006813 potassium ion transport;GO:1904044 response to aldosterone;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QWS8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62761-1", "uniprot_id": [ { "id": "KC1G1_RAT", "url": "https://www.uniprot.org/uniprot/Q62761", "type": "external" } ], "mass": 45127.0, "length": 390, "protein_name": "Casein kinase I isoform gamma-1", "gene_name": "Csnk1g1", "organism": "Rat", "refseq_name": "casein kinase I isoform gamma-1 isoform 5", "refseq_ac": [ { "id": "NP_071624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071624", "type": "external" } ], "gene_names_uniprotkb": "Csnk1g1", "gene_names_refseq": "Csnk1g1", "protein_names_uniprotkb": "Casein kinase I isoform gamma-1; 2.7.11.1; CKI-gamma 1", "protein_names_refseq": "CKI-gamma 1; casein kinase I isoform gamma-1 isoform 5; casein kinase I", "tax_id": 10116, "disease": "", "pathway": " (rno:64086)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7759525", "class_list": "", "function": "Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Phosphorylates CLSPN (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62761-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKI1-1", "uniprot_id": [ { "id": "IF4A2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKI1", "type": "external" } ], "mass": 46402.0, "length": 407, "protein_name": "Eukaryotic initiation factor 4A-II", "gene_name": "Eif4a2", "organism": "Rat", "refseq_name": "eukaryotic initiation factor 4A-II", "refseq_ac": [ { "id": "NP_001008336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008336", "type": "external" } ], "gene_names_uniprotkb": "Eif4a2", "gene_names_refseq": "Eif4a2", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-II; 3.6.4.13; ATP-dependent RNA helicase eIF4A-2; eIF-4A-II; eIF4A-II", "protein_names_refseq": "ATP-dependent RNA helicase eIF4A-2; eIF-4A-II; eIF4A-II; eukaryotic initiation factor 4A-II; eukaryotic translation initiation factor 4A; protein synthesis initiation factor 4AII", "tax_id": 10116, "disease": "neurodevelopmental disorder with hypotonia and speech delay (Disease Ontology:DOID:0070512)", "pathway": " (rno:303831); (R-RNO-156827); (R-RNO-429947); (R-RNO-72649); (R-RNO-72662); (R-RNO-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "18683930", "class_list": "", "function": "ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003743 translation initiation factor activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1900260 negative regulation of RNA-dependent RNA polymerase activity;GO:0002183 cytoplasmic translational initiation;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RKI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVG8-1", "uniprot_id": [ { "id": "GRM2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVG8", "type": "external" } ], "mass": 49229.0, "length": 445, "protein_name": "GRAM domain-containing protein 2B", "gene_name": "Gramd2b", "organism": "Rat", "refseq_name": "GRAM domain-containing protein 2B isoform 1", "refseq_ac": [ { "id": "NP_001014033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014033", "type": "external" } ], "gene_names_uniprotkb": "Gramd2b; Gramd3", "gene_names_refseq": "Gramd2b; Gramd3; RGD1311016", "protein_names_uniprotkb": "GRAM domain-containing protein 2B; GRAM domain-containing protein 3", "protein_names_refseq": "GRAM domain containing 3; GRAM domain-containing protein 2B isoform 1; GRAM domain-containing protein 2B; GRAM domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:307288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005881 cytoplasmic microtubule;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVG8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VJ4-1", "uniprot_id": [ { "id": "GPCP1_RAT", "url": "https://www.uniprot.org/uniprot/Q80VJ4", "type": "external" } ], "mass": 76269.0, "length": 672, "protein_name": "Glycerophosphocholine phosphodiesterase GPCPD1", "gene_name": "Gpcpd1", "organism": "Rat", "refseq_name": "glycerophosphocholine phosphodiesterase GPCPD1", "refseq_ac": [ { "id": "NP_942074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942074", "type": "external" } ], "gene_names_uniprotkb": "Gpcpd1; Gde5", "gene_names_refseq": "Gde5; Gpcpd1; Prei4; RGD735140", "protein_names_uniprotkb": "Glycerophosphocholine phosphodiesterase GPCPD1; 3.1.4.2; Glycerophosphodiester phosphodiesterase 5", "protein_names_refseq": "glycerophosphocholine phosphodiesterase GDE1 homolog; glycerophosphocholine phosphodiesterase GPCPD1; hypothetical protein LK44; preimplantation protein 4; putative glycerophosphocholine phosphodiesterase GPCPD1; putative glycerophosphodiester phosphodiesterase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:362219)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Shows strong preference for glycerophosphocholine. Displays weak activity toward glycerophosphoethanolamine and no detectable activity toward glycerophosphoglycerol, glycerophosphoserine, or glycerophosphoinosito. May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.2", "type": "external" } ], "go_molecular_function": "GO:2001070 starch binding;GO:0047389 glycerophosphocholine phosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046475 glycerophospholipid catabolic process;GO:0007519 skeletal muscle tissue development;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80VJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63356-1", "uniprot_id": [ { "id": "MYO1E_RAT", "url": "https://www.uniprot.org/uniprot/Q63356", "type": "external" } ], "mass": 126827.0, "length": 1107, "protein_name": "Unconventional myosin-Ie", "gene_name": "Myo1e", "organism": "Rat", "refseq_name": "unconventional myosin-Ie", "refseq_ac": [ { "id": "NP_775124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775124", "type": "external" } ], "gene_names_uniprotkb": "Myo1e; Myr3", "gene_names_refseq": "MYR5; Myo1e; Myr3", "protein_names_uniprotkb": "Unconventional myosin-Ie; Myosin heavy chain myr 3; Unconventional myosin 1E", "protein_names_refseq": "Unconventional myosin from rat 5; myosin heavy chain myr 3; myosin-Ie; unconventional myosin 1E; unconventional myosin-Ie", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis 6 (Disease Ontology:DOID:0111131)", "pathway": " (rno:25484)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12486594;29393594;7730414", "class_list": "", "function": "Myo1e found in hair cells of auditory and vestibular epithelia; enriched in cuticular plate, actin meshwork that anchors stereocilia., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated ve (By similarity)sicles. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function (By similarity). In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0001570 vasculogenesis;GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63356-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H74-1", "uniprot_id": [ { "id": "GLP3L_RAT", "url": "https://www.uniprot.org/uniprot/Q66H74", "type": "external" } ], "mass": 32922.0, "length": 285, "protein_name": "Golgi phosphoprotein 3-like", "gene_name": "Golph3l", "organism": "Rat", "refseq_name": "Golgi phosphoprotein 3-like", "refseq_ac": [ { "id": "NP_001007699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007699", "type": "external" } ], "gene_names_uniprotkb": "Golph3l", "gene_names_refseq": "Golph3l", "protein_names_uniprotkb": "Golgi phosphoprotein 3-like", "protein_names_refseq": "GPP34-related protein; Golgi phosphoprotein 3-like", "tax_id": 10116, "disease": "", "pathway": " (rno:310669)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11042173", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0048194 Golgi vesicle budding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI44-1", "uniprot_id": [ { "id": "NAA25_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI44", "type": "external" } ], "mass": 111258.0, "length": 970, "protein_name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit", "gene_name": "Naa25", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Naa25; Mdm20", "gene_names_refseq": "", "protein_names_uniprotkb": "N-alpha-acetyltransferase 25, NatB auxiliary subunit; Liver regeneration-related protein LRRGT00164; Mitochondrial distribution and morphology protein 20; N-terminal acetyltransferase B complex subunit MDM20; N-terminal acetyltransferase B complex subunit NAA25; NatB complex subunit MDM20", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:360811)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031416 NatB complex", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6QI44-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MG9-1", "uniprot_id": [ { "id": "KCIP4_RAT", "url": "https://www.uniprot.org/uniprot/Q99MG9", "type": "external" } ], "mass": 28756.0, "length": 250, "protein_name": "Kv channel-interacting protein 4", "gene_name": "Kcnip4", "organism": "Rat", "refseq_name": "Kv channel-interacting protein 4 isoform 1", "refseq_ac": [ { "id": "NP_852030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852030", "type": "external" } ], "gene_names_uniprotkb": "Kcnip4; Kchip4", "gene_names_refseq": "Kchip4; Kcnip4", "protein_names_uniprotkb": "Kv channel-interacting protein 4; A-type potassium channel modulatory protein 4; KChIP4; Potassium channel-interacting protein 4", "protein_names_refseq": "A-type potassium channel modulatory protein 4; Kv channel interacting protein 4; Kv channel-interacting protein 4 isoform 1; kv channel-interacting protein 4; potassium channel-interacting protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:259243); (R-RNO-5576894)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11351020;11805342;11847232;12829703;15356203;19441798;22673903;24037673;24811166;31792968", "class_list": "", "function": "Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity., [RefSeq, PubMed]; KChIP4 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability., [RefSeq, PubMed]; KChIP4a isoform, which exhibits unique effects on Kv4 channel gating negatively influences the impact of other KChIPs, [RefSeq, PubMed]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner., [UniProtKB, PubMed, PubMed, PubMed]; Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4., [RefSeq, PubMed]; This study demonistrared that the expression and function of KCHIP4 channels in neurons of the rat bed nucleus of the stria terminalis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MG8", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005509 calcium ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q99MG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWU3-1", "uniprot_id": [ { "id": "HNRDL_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWU3", "type": "external" } ], "mass": 35294.0, "length": 322, "protein_name": "Heterogeneous nuclear ribonucleoprotein D-like", "gene_name": "Hnrnpdl", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein D-like isoform 1", "refseq_ac": [ { "id": "NP_001028868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028868", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpdl; Hnrpdl", "gene_names_refseq": "Hnrnpdl; Hnrpdl; hnRNP DL", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein D-like; hnRNP D-like; hnRNP DL", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein D-like isoform 1; hnRNP D-like; hnRNP-DL; hnRPD-like protein", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306)", "pathway": " (rno:305178)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0008143 poly(A) binding;GO:0034046 poly(G) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3SWU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIQ2-1", "uniprot_id": [ { "id": "ELMD3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIQ2", "type": "external" } ], "mass": 40014.0, "length": 356, "protein_name": "ELMO domain-containing protein 3", "gene_name": "Elmod3", "organism": "Rat", "refseq_name": "ELMO domain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001013105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013105", "type": "external" } ], "gene_names_uniprotkb": "Elmod3; Rbed1", "gene_names_refseq": "Elmod3; Kcmf1; Rbed1", "protein_names_uniprotkb": "ELMO domain-containing protein 3; RNA-binding motif and ELMO domain-containing protein 1", "protein_names_refseq": "ELMO domain-containing protein 3 isoform 2; ELMO domain-containing protein 3; ELMO/CED-12 domain containing 3; RNA binding motif and ELMO domain 1; RNA-binding motif and ELMO domain-containing protein 1; potassium channel modulatory factor 1", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 81 (Disease Ontology:DOID:0070608); autosomal recessive nonsyndromic deafness 88 (Disease Ontology:DOID:0110533)", "pathway": " (rno:297342)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24039609", "class_list": "", "function": "Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005929 cilium;GO:0060091 kinocilium;GO:0032420 stereocilium", "go_biological_process": "GO:0015031 protein transport;GO:0007010 cytoskeleton organization;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWS6-1", "uniprot_id": [ { "id": "KAZRN_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWS6", "type": "external" } ], "mass": 86974.0, "length": 780, "protein_name": "Kazrin", "gene_name": "Kazn", "organism": "Rat", "refseq_name": "kazrin isoform 2", "refseq_ac": [ { "id": "NP_001014092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014092", "type": "external" } ], "gene_names_uniprotkb": "Kazn; Kaz", "gene_names_refseq": "Kazn; Kaz", "protein_names_uniprotkb": "Kazrin", "protein_names_refseq": "kazrin isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:313672); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016607 nuclear speck;GO:0001533 cornified envelope", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FWS6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62762-1", "uniprot_id": [ { "id": "KC1G2_RAT", "url": "https://www.uniprot.org/uniprot/Q62762", "type": "external" } ], "mass": 47636.0, "length": 415, "protein_name": "Casein kinase I isoform gamma-2", "gene_name": "Csnk1g2", "organism": "Rat", "refseq_name": "casein kinase I isoform gamma-2 isoform 1", "refseq_ac": [ { "id": "NP_001029042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029042", "type": "external" } ], "gene_names_uniprotkb": "Csnk1g2; Ck1g2", "gene_names_refseq": "Csnk1g2", "protein_names_uniprotkb": "Casein kinase I isoform gamma-2; 2.7.11.1; CKI-gamma 2", "protein_names_refseq": "CKI-gamma 2; casein kinase I isoform gamma-2 isoform 1; casein kinase I", "tax_id": 10116, "disease": "", "pathway": " (rno:65278)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7759525", "class_list": "", "function": "Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IMY5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0046777 protein autophosphorylation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62762-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP98-1", "uniprot_id": [ { "id": "ILF2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP98", "type": "external" } ], "mass": 51381.0, "length": 463, "protein_name": "Interleukin enhancer-binding factor 2", "gene_name": "Ilf2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ilf2; Ab1-143", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin enhancer-binding factor 2; Liver regeneration-related protein LRRG031", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:310612); (R-RNO-6798695); (R-RNO-9833482)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Plays also a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TP98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Z3-1", "uniprot_id": [ { "id": "NP1L4_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Z3", "type": "external" } ], "mass": 43917.0, "length": 386, "protein_name": "Nucleosome assembly protein 1-like 4", "gene_name": "Nap1l4", "organism": "Rat", "refseq_name": "nucleosome assembly protein 1-like 4 isoform 1", "refseq_ac": [ { "id": "NP_001012170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012170", "type": "external" } ], "gene_names_uniprotkb": "Nap1l4", "gene_names_refseq": "Nap1l4", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 4; Histone chaperone NAP1L4", "protein_names_refseq": "histone chaperone NAP1L4; nucleosome assembly protein 1-like 4 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361684)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Acts as a histone chaperone in nucleosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHI5-1", "uniprot_id": [ { "id": "PER1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHI5", "type": "external" } ], "mass": 136164.0, "length": 1293, "protein_name": "Period circadian protein homolog 1", "gene_name": "Per1", "organism": "Rat", "refseq_name": "period circadian protein homolog 1", "refseq_ac": [ { "id": "NP_001029297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029297", "type": "external" } ], "gene_names_uniprotkb": "Per1", "gene_names_refseq": "Per1; rper1", "protein_names_uniprotkb": "Period circadian protein homolog 1; Circadian clock protein PERIOD 1; rPER1", "protein_names_refseq": "circadian clock protein PERIOD 1; period 1; period circadian clock 1; period circadian protein homolog 1; period homolog 1", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:287422); (R-RNO-9932298)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11597585;12710990;15094047;15860628;24447840;36093781;36450128;37338051;37907921;39010104", "class_list": "", "function": "Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3beta/beta-CATENIN pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-kappaB pathway: an in vitro and in vivo study. Publication Status: Online-Only, [RefSeq, PubMed]; Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats., [RefSeq, PubMed]; Pers reverse angiotensin II -induced vascular smooth muscle cell proliferation by targeting cyclin E expression via inhibition of the MAPK signaling pathway., [RefSeq, PubMed]; The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats., [RefSeq, PubMed]; This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/BMAL1 target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by BMAL1:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2KMM8", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003407 neural retina development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CHI5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLG2-1", "uniprot_id": [ { "id": "GIMA8_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLG2", "type": "external" } ], "mass": 77072.0, "length": 688, "protein_name": "GTPase IMAP family member 8", "gene_name": "Gimap8", "organism": "Rat", "refseq_name": "GTPase IMAP family member 8", "refseq_ac": [ { "id": "NP_001029095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029095", "type": "external" } ], "gene_names_uniprotkb": "Gimap8; Ian9; Iant", "gene_names_refseq": "Gimap8; IanT", "protein_names_uniprotkb": "GTPase IMAP family member 8; IAN-9; Immune-associated nucleotide-binding protein 9; Protein IanT", "protein_names_refseq": "GTPase IMAP family member 8; IAN-9; immune-associated nucleotide-binding protein 9; protein IanT", "tax_id": 10116, "disease": "", "pathway": " (rno:500112)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16103028;29393594", "class_list": "", "function": "Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3LF72", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0070232 regulation of T cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63504-1", "uniprot_id": [ { "id": "NR1D2_RAT", "url": "https://www.uniprot.org/uniprot/Q63504", "type": "external" } ], "mass": 64192.0, "length": 578, "protein_name": "Nuclear receptor subfamily 1 group D member 2", "gene_name": "Nr1d2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 1 group D member 2", "refseq_ac": [ { "id": "NP_671743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671743", "type": "external" } ], "gene_names_uniprotkb": "Nr1d2", "gene_names_refseq": "HZF-2; Nr1d2", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 2; EAR4; Rev-erb-beta", "protein_names_refseq": "EAR4; Rev-ErbA-beta; Rev-erb-Beta2; nuclear receptor subfamily 1 group D member 2; orphan nuclear receptor HZF-2; orphan receptor; rev-erb-beta", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651)", "pathway": " (rno:259241); (R-RNO-383280)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "29393594;36077427;7945391;8747539", "class_list": "", "function": "Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1. Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN. Regulates hepatic lipid metabolism via the repression of APOC3. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). In addition to its activity as a repressor, can also act as a transcriptional activator. Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity). Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity). Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity). May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62756;Q63542", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63504-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H4-1", "uniprot_id": [ { "id": "KLH12_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H4", "type": "external" } ], "mass": 63306.0, "length": 568, "protein_name": "Kelch-like protein 12", "gene_name": "Klhl12", "organism": "Rat", "refseq_name": "kelch-like protein 12", "refseq_ac": [ { "id": "NP_714952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714952", "type": "external" } ], "gene_names_uniprotkb": "Klhl12; C3ip1", "gene_names_refseq": "C3ip1; Klhl12", "protein_names_uniprotkb": "Kelch-like protein 12; CUL3-interacting protein 1", "protein_names_refseq": "CUL3-interacting protein 1; kelch-like 12; kelch-like protein 12; kelch-like protein C3IP1", "tax_id": 10116, "disease": "", "pathway": " (rno:266772); (R-RNO-4641258)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24334870", "class_list": "", "function": "KLHL12 plays a critical role in facilitating the endoplasmic reticulum exit and secretion of apoB100-VLDL particles, suggesting that KLHL12 modulation would influence plasma lipid levels., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WG02", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R2H4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG56-1", "uniprot_id": [ { "id": "LY66F_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG56", "type": "external" } ], "mass": 32615.0, "length": 293, "protein_name": "Lymphocyte antigen 6 complex locus protein G6f", "gene_name": "Ly6g6f", "organism": "Rat", "refseq_name": "lymphocyte antigen 6 complex locus protein G6f precursor", "refseq_ac": [ { "id": "NP_001003691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003691", "type": "external" } ], "gene_names_uniprotkb": "Ly6g6f; G6f; Ly6g6d", "gene_names_refseq": "G6f; Ly6g6f", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6f", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G6f precursor; lymphocyte antigen 6 complex locus protein G6f; lymphocyte antigen 6 complex, locus G6F", "tax_id": 10116, "disease": "", "pathway": " (rno:309609); (R-RNO-114608)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "May play a role in the downstream signal transduction pathways involving GRB2 and GRB7., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG56-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4G8-1", "uniprot_id": [ { "id": "KCTD1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4G8", "type": "external" } ], "mass": 29435.0, "length": 257, "protein_name": "BTB/POZ domain-containing protein KCTD1", "gene_name": "Kctd1", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD1 isoform X3", "refseq_ac": [ { "id": "XP_038952670", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038952670", "type": "external" } ], "gene_names_uniprotkb": "Kctd1; Vad6", "gene_names_refseq": "Kctd1; Vad5; Vad", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD1; Potassium channel tetramerization domain-containing protein 1; Vitamin A-deficient testicular protein 6", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD1 isoform X3", "tax_id": 10116, "disease": "scalp-ear-nipple syndrome (Disease Ontology:DOID:0111550)", "pathway": " (rno:291772); (R-RNO-8866904)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12878178;22673903", "class_list": "", "function": "Is a regulator of different signaling pathways. Up-regulates ADCY5 thereby enhancing cAMP signaling, and is involved in the negative regulation of Wnt canonical, Hh and Notch signaling (By similarity). Is a repressor of transcriptional activation mediated by AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R4G8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJM0-1", "uniprot_id": [ { "id": "MK67I_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJM0", "type": "external" } ], "mass": 31351.0, "length": 271, "protein_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "gene_name": "Nifk", "organism": "Rat", "refseq_name": "MKI67 FHA domain-interacting nucleolar phosphoprotein", "refseq_ac": [ { "id": "NP_631925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631925", "type": "external" } ], "gene_names_uniprotkb": "Nifk; Mki67ip", "gene_names_refseq": "Mki67ip; Nifk", "protein_names_uniprotkb": "MKI67 FHA domain-interacting nucleolar phosphoprotein; Nucleolar protein interacting with the FHA domain of pKI-67", "protein_names_refseq": "MKI67 FHA domain-interacting nucleolar phosphoprotein; Mki67 (FHA domain) interacting nucleolar phosphoprotein; nucleolar protein interacting with the FHA domain of pKI-67; spermatogenesis-related protein (Srp)", "tax_id": 10116, "disease": "", "pathway": " (rno:246042)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJE2-1", "uniprot_id": [ { "id": "PER3_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJE2", "type": "external" } ], "mass": 122686.0, "length": 1119, "protein_name": "Period circadian protein homolog 3", "gene_name": "Per3", "organism": "Rat", "refseq_name": "period circadian protein homolog 3", "refseq_ac": [ { "id": "NP_076468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076468", "type": "external" } ], "gene_names_uniprotkb": "Per3", "gene_names_refseq": "Per3; period3; rper3", "protein_names_uniprotkb": "Period circadian protein homolog 3; Circadian clock protein PERIOD 3; rPER3", "protein_names_refseq": "circadian clock protein PERIOD 3; period circadian clock 3; period circadian protein homolog 3; period homolog 3", "tax_id": 10116, "disease": "advanced sleep phase syndrome (Disease Ontology:DOID:0050628); advanced sleep phase syndrome 3 (Disease Ontology:DOID:0110013); alcohol use disorder (Disease Ontology:DOID:1574); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (rno:78962); (R-RNO-9932298)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1, NR1D2, RORA, RORB and RORG, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. Has a redundant role with the other PER proteins PER1 and PER2 and is not essential for the circadian rhythms maintenance. In contrast, plays an important role in sleep-wake timing and sleep homeostasis probably through the transcriptional regulation of sleep homeostasis-related genes, without influencing circadian parameters. Can bind heme., [UniProtKB, UniProtKB, UniProtKB]; This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been linked to sleep disorders. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0050821 protein stabilization;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CJE2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJI5-1", "uniprot_id": [ { "id": "NMUR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJI5", "type": "external" } ], "mass": 48129.0, "length": 425, "protein_name": "Neuromedin-U receptor 1", "gene_name": "Nmur1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nmur1; Gpr66; NMU1R", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuromedin-U receptor 1; FM-3; G protein-coupled receptor 66; G protein-coupled receptor FM-3; NMU-R1", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65276); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10783389;10894543", "class_list": "", "function": "G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10783389). Functionally, is involved in regulation of feeding and energy balance (PubMed:10894543). Additionally modulates blood pressure, smooth muscle contraction, hormone release and inflammatory responses in a tissue- and receptor-dependent manner (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum. Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation (By similarity). In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels. Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB]; Receptor for the neuromedin-U and neuromedin-S neuropeptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LQC9;Q9JIB2", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0001607 neuromedin U receptor activity;GO:0042924 neuromedin U binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007218 neuropeptide signaling pathway;GO:0019722 calcium-mediated signaling;GO:0050850 positive regulation of calcium-mediated signaling;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJI5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64725-1", "uniprot_id": [ { "id": "KSYK_RAT", "url": "https://www.uniprot.org/uniprot/Q64725", "type": "external" } ], "mass": 71529.0, "length": 629, "protein_name": "Tyrosine-protein kinase SYK", "gene_name": "Syk", "organism": "Rat", "refseq_name": "tyrosine-protein kinase SYK", "refseq_ac": [ { "id": "NP_036890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036890", "type": "external" } ], "gene_names_uniprotkb": "Syk", "gene_names_refseq": "Syk; p72syk", "protein_names_uniprotkb": "Tyrosine-protein kinase SYK; 2.7.10.2; Spleen tyrosine kinase; p72Syk", "protein_names_refseq": "spleen tyrosine kinase; tyrosine-protein kinase SYK", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); immunodeficiency 82 (Disease Ontology:DOID:0061053); sleeping sickness (Disease Ontology:DOID:10112); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); hypospadias (Disease Ontology:DOID:10892); functional diarrhea (Disease Ontology:DOID:11371); Pick's disease (Disease Ontology:DOID:11870); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); rectal benign neoplasm (Disease Ontology:DOID:1984); Wernicke encephalopathy (Disease Ontology:DOID:2384); morphine dependence (Disease Ontology:DOID:2560); glomerulonephritis (Disease Ontology:DOID:2921); temporal lobe epilepsy (Disease Ontology:DOID:3328); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); migraine (Disease Ontology:DOID:6364); amphetamine abuse (Disease Ontology:DOID:670); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); degenerative disc disease (Disease Ontology:DOID:90); acute myocardial infarction (Disease Ontology:DOID:9408); irritable bowel syndrome (Disease Ontology:DOID:9778); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:25155); (R-RNO-114604); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-2424491); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-354192); (R-RNO-5621480); (R-RNO-9020558); (R-RNO-912631); (R-RNO-9674555); (R-RNO-9705462); (R-RNO-983695)", "pathway_count": 17, "publication_count": 9, "publication_id_list": "12077122;20053395;23544131;28393919;29845271;29901140;30942391;7759516;8611520", "class_list": "", "function": "Cryptotanshinone inhibits IgEmediated degranulation through inhibition of spleen tyrosine kinase and tyrosineprotein kinase phosphorylation in mast cells. Erratum:[Mol Med Rep. 2021 Sep;24(3):644. doi: 10.3892/mmr.2021.12283. PMID: 34278499], [RefSeq, PubMed]; It was demonstrated in the present study that Syk was markedly activated in the development of Diabetic cardiomyopathy, subsequently promoting NLRP3 inflammasome activation through the phosphorylation of JNK, leading to the cleavage of pro-caspase-1 and maturation of IL-1beta, and finally contributing to diabetic cardiac dysfunction., [RefSeq, PubMed]; Mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex. Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Required for the stimulation of neutrophil phagocytosis by IL15 (By similarity). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Present results determined that high glucoseinduced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL1beta and mature IL1beta. The present study identified that the Syk/JNK/NLRP3 signaling pathway may serve a vital role in the pathogenesis ofdiabetic nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 32, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042101 T cell receptor complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0002366 leukocyte activation involved in immune response;GO:0032752 positive regulation of interleukin-3 production;GO:0002283 neutrophil activation involved in immune response;GO:0002554 serotonin secretion by platelet", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQU7-1", "uniprot_id": [ { "id": "GRTP1_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQU7", "type": "external" } ], "mass": 32929.0, "length": 289, "protein_name": "Growth hormone-regulated TBC protein 1", "gene_name": "Adprhl1; Grtp1", "organism": "Rat", "refseq_name": "growth hormone-regulated TBC protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001026983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026983", "type": "external" } ], "gene_names_uniprotkb": "Adprhl1; Grtp1; Adprhl1; Grtp1", "gene_names_refseq": "Grtp1; LRRGT00052", "protein_names_uniprotkb": "Growth hormone-regulated TBC protein 1", "protein_names_refseq": "GH regulated TBC protein 1; growth hormone-regulated TBC protein 1 isoform 2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (rno:361180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046872 metal ion binding;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQU7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5R212-1", "uniprot_id": [ { "id": "PRS35_RAT", "url": "https://www.uniprot.org/uniprot/Q5R212", "type": "external" } ], "mass": 45496.0, "length": 406, "protein_name": "Inactive serine protease 35", "gene_name": "Prss35", "organism": "Rat", "refseq_name": "inactive serine protease 35 precursor", "refseq_ac": [ { "id": "NP_001008560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008560", "type": "external" } ], "gene_names_uniprotkb": "Prss35", "gene_names_refseq": "Prss35", "protein_names_uniprotkb": "Inactive serine protease 35", "protein_names_refseq": "inactive serine protease 35 precursor; inactive serine protease 35; protease, serine, 35", "tax_id": 10116, "disease": "", "pathway": " (rno:315866)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5R212-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63421-1", "uniprot_id": [ { "id": "PDE1C_RAT", "url": "https://www.uniprot.org/uniprot/Q63421", "type": "external" } ], "mass": 86671.0, "length": 768, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C", "gene_name": "Pde1c", "organism": "Rat", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C", "refseq_ac": [ { "id": "NP_112340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112340", "type": "external" } ], "gene_names_uniprotkb": "Pde1c; Pde1c2", "gene_names_refseq": "Pde1c", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; 3.1.4.17; Cam-PDE 1C", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; cam-PDE 1C; cyclic nucleotide phosphodiesterase 1 C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; phosphodiesterase 1C calmodulin-dependent (70kD)", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 74 (Disease Ontology:DOID:0112165)", "pathway": " (rno:81742); (R-RNO-111957)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "19741056;21148428;22673903;25608528;35538034;7568196", "class_list": "", "function": "Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (PubMed:7568196). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (By similarity). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (PubMed:19741056)., [UniProtKB, UniProtKB, PubMed, PubMed]; Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C., [RefSeq, PubMed]; In cultured rat aortic SMCs, PDE1C deficiency or PDE1 inhibition attenuated SMC proliferation and migration. PDE1C plays a critical role in regulating the stability of growth factor receptors, endocytosis and lysosome-dependent degradation., [RefSeq, PubMed]; Suggest that PDE1C plays a critical role in regulating collagen homeostasis during pathological vascular remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005929 cilium;GO:0043025 neuronal cell body;GO:0005764 lysosome", "go_biological_process": "GO:0007165 signal transduction;GO:0051592 response to calcium ion;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0007608 sensory perception of smell;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63421-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NA5-1", "uniprot_id": [ { "id": "IDH3A_RAT", "url": "https://www.uniprot.org/uniprot/Q99NA5", "type": "external" } ], "mass": 39614.0, "length": 366, "protein_name": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial", "gene_name": "Idh3a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Idh3a", "gene_names_refseq": "", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; 1.1.1.41; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 90 (Disease Ontology:DOID:0112147); neuromuscular junction disease (Disease Ontology:DOID:439)", "pathway": " (rno:114096); (R-RNO-71403); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11237704;18047804;18683930;27213235;34502162", "class_list": "", "function": "Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99NA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHU4-1", "uniprot_id": [ { "id": "ELP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHU4", "type": "external" } ], "mass": 149171.0, "length": 1331, "protein_name": "Elongator complex protein 1", "gene_name": "Elp1", "organism": "Rat", "refseq_name": "elongator complex protein 1", "refseq_ac": [ { "id": "NP_543175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543175", "type": "external" } ], "gene_names_uniprotkb": "Elp1; Ikap; Ikbkap", "gene_names_refseq": "Elp1; IKAP; Ikbkap", "protein_names_uniprotkb": "Elongator complex protein 1; ELP1; IKK complex-associated protein; IkappaB kinase complex-associated protein", "protein_names_refseq": "IKK complex-associated protein; elongator complex protein 1-like; elongator complex protein 1; ikappaB kinase complex-associated protein; inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein", "tax_id": 10116, "disease": "hemophagocytic lymphohistiocytosis (Disease Ontology:DOID:0050120); medulloblastoma (Disease Ontology:DOID:0050902); scoliosis (Disease Ontology:DOID:0060249); familial dysautonomia (Disease Ontology:DOID:11589); asthma (Disease Ontology:DOID:2841); kyphosis (Disease Ontology:DOID:4667)", "pathway": " (rno:140934)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11722848;20184874", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Organ culture of bronchi induces IkappaB kinase mediated inflammatory changes resulting in airway hyperresponsiveness to bradykinin via the up-regulation of bradykinin receptors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0007252 I-kappaB phosphorylation;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHU4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63085-1", "uniprot_id": [ { "id": "PDE3B_RAT", "url": "https://www.uniprot.org/uniprot/Q63085", "type": "external" } ], "mass": 123107.0, "length": 1108, "protein_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B", "gene_name": "Pde3b", "organism": "Rat", "refseq_name": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B", "refseq_ac": [ { "id": "NP_058925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058925", "type": "external" } ], "gene_names_uniprotkb": "Pde3b", "gene_names_refseq": "CGI PDE; Pde3b; RcGIPl", "protein_names_uniprotkb": "cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; 3.1.4.17; CGI PDE; CGI-PDE B; Cyclic GMP-inhibited phosphodiesterase B; RcGIPl", "protein_names_refseq": "CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; cyclic GMP-inhibited phosphodiesterase B; phosphodiesterase 3B, cGMP-inhibited", "tax_id": 10116, "disease": "", "pathway": " (rno:29516); (R-RNO-165160); (R-RNO-418555)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10417351;21435395;22967108;22990990;35030973;8395509;9500857;9631240", "class_list": "", "function": "C-peptide has the potential to act, conditionally, as an antilipolytic hormone by activating phosphodiesterase-3B., [RefSeq, PubMed]; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:9631240). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data demonstrate that AG/UAG attenuation of ISO-induced lipolysis involves PI3Kgamma/AKT and PDE3B., [RefSeq, PubMed]; Diosgenin reduces phosphodiesterase 3B (PDE3B) through AMP-activated protein kinase/ mechanistic target of rapamycin (AMPK/mTOR) signaling pathway to ameliorate streptozotocin-induced pancreatic beta-cell apoptosis and dysfunction., [RefSeq, PubMed]; PI3K but not Akt is an upstream regulator of the PDE3B pathway of leptin signalling in the rat hypothalamus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051219 phosphoprotein binding;GO:0043422 protein kinase B binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0032045 guanyl-nucleotide exchange factor complex", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001525 angiogenesis;GO:0007162 negative regulation of cell adhesion;GO:0050995 negative regulation of lipid catabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63085-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R523-1", "uniprot_id": [ { "id": "KCNG3_RAT", "url": "https://www.uniprot.org/uniprot/Q8R523", "type": "external" } ], "mass": 49291.0, "length": 433, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG3", "gene_name": "Kcng3", "organism": "Rat", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG3 isoform 2", "refseq_ac": [ { "id": "NP_001029129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029129", "type": "external" } ], "gene_names_uniprotkb": "Kcng3", "gene_names_refseq": "Kcng3; Kv10.1; Kv6.3", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG3; Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3", "protein_names_refseq": "potassium channel, voltage gated modifier subfamily G, member 3; potassium voltage-gated channel, subfamily G, member 3; potassium voltage-gated channel, subfamily G, memeber 3; voltage-gated potassium channel 6.3; voltage-gated potassium channel regulatory subunit KCNG3 isoform 2; voltage-gated potassium channel regulatory subunit KCNG3; voltage-gated potassium channel subunit Kv10.1; voltage-gated potassium channel subunit Kv6.3", "tax_id": 10116, "disease": "", "pathway": " (rno:171011); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11852086;19074135", "class_list": "", "function": "Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the inactivation and deactivation rate. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Moderately acceleratee activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0043266 regulation of potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R523-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62611-1", "uniprot_id": [ { "id": "ILRL1_RAT", "url": "https://www.uniprot.org/uniprot/Q62611", "type": "external" } ], "mass": 64406.0, "length": 566, "protein_name": "Interleukin-1 receptor-like 1", "gene_name": "Il1rl1", "organism": "Rat", "refseq_name": "interleukin-1 receptor-like 1 isoform Fit-1M precursor", "refseq_ac": [ { "id": "NP_001121161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121161", "type": "external" } ], "gene_names_uniprotkb": "Il1rl1; Fit1", "gene_names_refseq": "FIT1; Fit-1; IL33R; Il1rl1; ST2-L; St2; T1/ST2; sST2", "protein_names_uniprotkb": "Interleukin-1 receptor-like 1; 3.2.2.6; Fit-1; Fos-responsive gene 1 protein", "protein_names_refseq": "IL-33 receptor; fos-responsive gene 1 protein; interleukin-1 receptor-like 1 isoform Fit-1M precursor; serum St2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); acute asthma (Disease Ontology:DOID:0080810); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); paracoccidioidomycosis (Disease Ontology:DOID:12662); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:25556); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9014843)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "36768322;38142925;38724005;8131748", "class_list": "", "function": "Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats., [RefSeq, PubMed]; Inhibits IL-33 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence., [RefSeq, PubMed]; Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (By similarity). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q62612", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0002113 interleukin-33 binding;GO:0002114 interleukin-33 receptor activity;GO:0004908 interleukin-1 receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0043032 positive regulation of macrophage activation;GO:1990859 cellular response to endothelin;GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62611-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE51-1", "uniprot_id": [ { "id": "ISK7_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE51", "type": "external" } ], "mass": 8210.0, "length": 74, "protein_name": "Serine protease inhibitor Kazal-type 7", "gene_name": "Spink7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spink7; Ecg2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 7; ECRG-2; Esophagus cancer-related gene 2 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:408237)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Probable serine protease inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:1900016 negative regulation of cytokine production involved in inflammatory response;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62640-1", "uniprot_id": [ { "id": "GRID1_RAT", "url": "https://www.uniprot.org/uniprot/Q62640", "type": "external" } ], "mass": 112125.0, "length": 1009, "protein_name": "Glutamate receptor ionotropic, delta-1", "gene_name": "Grid1", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, delta-1 precursor", "refseq_ac": [ { "id": "NP_077354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077354", "type": "external" } ], "gene_names_uniprotkb": "Grid1", "gene_names_refseq": "GluD1; Grid1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, delta-1; GluD1; GluR delta-1 subunit", "protein_names_refseq": "gluR delta-1 subunit; glutamate receptor delta-1 subunit; glutamate receptor ionotropic, delta-1 precursor; glutamate receptor ionotropic, delta-1-like; glutamate receptor, ionotropic, delta 1", "tax_id": 10116, "disease": "", "pathway": " (rno:79219)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31925409;38479882;8422924", "class_list": "", "function": "Grid1 regulates the onset of puberty in female rats., [RefSeq, PubMed]; Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Instead, forms trans-synaptic adhesion complexes with presynaptic neurexins and cerebellins, regulating NMDA and AMPA receptor activity and influencing synaptic plasticity through signal transduction. In the presence of NRX1B-CBLN1, forms cation-selective channels that are proposed to be gated by glycine and D-serine. However, recent research disputes this ligand-gated cation channel activity. Cation-selective ion channel can be triggered by GRM1 in dopaminergic neurons. Also acts as a receptor for GABA, modulating inhibitory synaptic plasticity through non-ionotropic mechanisms., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]; This study reports the cryo-EM structures of the rat GluD1 receptor complexed with calcium and the ligand 7-chlorokynurenic acid (7-CKA), elucidating molecular architecture and principles of receptor assembly., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q63225", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0035176 social behavior;GO:0050804 modulation of chemical synaptic transmission;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62640-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62826-1", "uniprot_id": [ { "id": "HNRPM_RAT", "url": "https://www.uniprot.org/uniprot/Q62826", "type": "external" } ], "mass": 73782.0, "length": 690, "protein_name": "Heterogeneous nuclear ribonucleoprotein M", "gene_name": "Hnrnpm", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein M isoform a", "refseq_ac": [ { "id": "NP_001103381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103381", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpm; Hnrpm", "gene_names_refseq": "Hnrnpm; Hnrpm4; Hnrpm", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein M; M4 protein; hnRNP M", "protein_names_refseq": "M4 protein; heterogeneous nuclear ribonucleoprotein M isoform a; hnRNP M", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); leiomyoma (Disease Ontology:DOID:127)", "pathway": " (rno:116655)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10947964;11406629;16128803;22673903", "class_list": "", "function": "Pre-mRNA binding protein, binds avidly to poly(G) and poly(U) RNA homopolymers. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M815", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:1990405 protein antigen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:1904591 positive regulation of protein import;GO:0071222 cellular response to lipopolysaccharide;GO:1900182 positive regulation of protein localization to nucleus;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62826-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYJ6-1", "uniprot_id": [ { "id": "PDE10_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYJ6", "type": "external" } ], "mass": 90161.0, "length": 794, "protein_name": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A", "gene_name": "Pde10a", "organism": "Rat", "refseq_name": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1", "refseq_ac": [ { "id": "NP_071572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071572", "type": "external" } ], "gene_names_uniprotkb": "Pde10a", "gene_names_refseq": "Pde10a3; Pde10a", "protein_names_uniprotkb": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; 3.1.4.17", "protein_names_refseq": "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; testis-specific phosphodiesterase PDE10A2", "tax_id": 10116, "disease": "striatal degeneration 2 (Disease Ontology:DOID:0060998); traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (rno:63885); (R-RNO-418457); (R-RNO-418555)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10583409;12967715;14604994;14752115;17228859;20610737;22142545;26256420;29215295;36671394", "class_list": "", "function": "A subset of Pde10A splice variants are up-regulated after long term potentiation induction, [RefSeq, PubMed]; Analysis of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia in the rat model, [RefSeq, PubMed]; CAMP signaling pathway-related proteins, Pde10a and Gnal, may play important roles in the pathogenesis and recovery of mild traumatic brain injury., [RefSeq, PubMed]; High levels of mRNA are observed in most of the neuronal cell bodies of striatal complex.PDE10A-like immunoreactivity is dense throughout the striatal neuropil, as well as in the internal capsule, globus pallidus, and substantia nigra., [RefSeq, PubMed]; Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy. Publication Status: Online-Only, [RefSeq, PubMed]; PDE10A proteins, especially PDE10A2, are more abundant in membrane fractions than in cytosolic fractions of striatum, [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate., [UniProtKB, PubMed]; Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6S9E6;Q6S9E7;Q6S9E8;Q6S9E9;Q9QYJ5", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0046069 cGMP catabolic process;GO:0010754 negative regulation of cGMP-mediated signaling;GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498D9-1", "uniprot_id": [ { "id": "GIPC2_RAT", "url": "https://www.uniprot.org/uniprot/Q498D9", "type": "external" } ], "mass": 34202.0, "length": 314, "protein_name": "PDZ domain-containing protein GIPC2", "gene_name": "Gipc2", "organism": "Rat", "refseq_name": "PDZ domain-containing protein GIPC2", "refseq_ac": [ { "id": "NP_001032287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032287", "type": "external" } ], "gene_names_uniprotkb": "Gipc2", "gene_names_refseq": "Gipc2", "protein_names_uniprotkb": "PDZ domain-containing protein GIPC2", "protein_names_refseq": "PDZ domain-containing protein GIPC2; semaF cytoplasmic domain associated protein 2", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:365960)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498D9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71RP1-1", "uniprot_id": [ { "id": "HPSE_RAT", "url": "https://www.uniprot.org/uniprot/Q71RP1", "type": "external" } ], "mass": 60480.0, "length": 536, "protein_name": "Heparanase", "gene_name": "Hpse", "organism": "Rat", "refseq_name": "heparanase precursor", "refseq_ac": [ { "id": "NP_072127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072127", "type": "external" } ], "gene_names_uniprotkb": "Hpse; Hep", "gene_names_refseq": "Hep; Hpa; Hpse", "protein_names_uniprotkb": "Heparanase; 3.2.1.166; Endo-glucoronidase", "protein_names_refseq": "endo-glucoronidase; heparanase precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:64537); (R-RNO-2024096); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10395326;11988100;12077130;15677344;24608441;26638897;27979811;28720149;29581478", "class_list": "glycogene;glycosylhydrolase", "function": "Characterization of a novel intracellular heparanase that has a FERM domain., [RefSeq, PubMed]; Characterization of rat heparanase activity in a parathyroid cell line, [RefSeq, PubMed]; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as a procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis (By similarity)., [UniProtKB, PubMed]; Endothelial cell-to-cardiomyocyte transfer of heparanase to modulates the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy., [RefSeq, PubMed]; Heparanase plays an important role in mediating the neuroinflammatory response after subarachnoid hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibiting heparanase function could offer a new strategy for managing cardiomyopathy observed after diabetes., [RefSeq, PubMed]; The expression of the gene for heparanase was increased in the right and left ventricles after treatment with monocrotaline, [RefSeq, PubMed]; We identified Hpse as a previously unexplored candidate, being up-regulated following injury. We confirmed these results and demonstrated inhibition of Hpse led to an acceleration of axonal degeneration, accompanied by an increase in b-catenin Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZF8", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0045545 syndecan binding;GO:0030305 heparanase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005768 endosome", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q71RP1-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76HN1-1", "uniprot_id": [ { "id": "HYAL1_RAT", "url": "https://www.uniprot.org/uniprot/Q76HN1", "type": "external" } ], "mass": 50645.0, "length": 449, "protein_name": "Hyaluronidase-1", "gene_name": "Hyal1", "organism": "Rat", "refseq_name": "hyaluronidase-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_997499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997499", "type": "external" } ], "gene_names_uniprotkb": "Hyal1", "gene_names_refseq": "Hyal1", "protein_names_uniprotkb": "Hyaluronidase-1; 3.2.1.35; Hyal-1; Hyaluronoglucosaminidase-1", "protein_names_refseq": "hyal-1; hyaluronidase-1 isoform 1 precursor; hyaluronoglucosaminidase 1", "tax_id": 10116, "disease": "mucopolysaccharidosis IX (Disease Ontology:DOID:0050809); mucopolysaccharidosis (Disease Ontology:DOID:12798); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:367166); (R-RNO-2024101); (R-RNO-2160916)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12397638;33904385", "class_list": "glycogene;glycosylhydrolase", "function": "Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2)., [RefSeq, PubMed]; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity). Overexpression of HYAL1 suppressed the growth rate of colon carcinoma cell tumors in an experimental model., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0052757 chondroitin hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0036117 hyaluranon cable;GO:0005576 extracellular region", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006954 inflammatory response;GO:0030307 positive regulation of cell growth;GO:0045785 positive regulation of cell adhesion;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q76HN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZB0-1", "uniprot_id": [ { "id": "PORIM_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZB0", "type": "external" } ], "mass": 19984.0, "length": 194, "protein_name": "Porimin", "gene_name": "Tmem123", "organism": "Rat", "refseq_name": "porimin precursor", "refseq_ac": [ { "id": "NP_001014227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014227", "type": "external" } ], "gene_names_uniprotkb": "Tmem123", "gene_names_refseq": "RGD1305625; Tmem123", "protein_names_uniprotkb": "Porimin; Transmembrane protein 123", "protein_names_refseq": "porimin precursor; porimin", "tax_id": 10116, "disease": "", "pathway": " (rno:363013)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZB0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3E9-1", "uniprot_id": [ { "id": "HOMEZ_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3E9", "type": "external" } ], "mass": 57677.0, "length": 513, "protein_name": "Homeobox and leucine zipper protein Homez", "gene_name": "Homez", "organism": "Rat", "refseq_name": "homeobox and leucine zipper protein Homez isoform X2", "refseq_ac": [ { "id": "XP_008768885", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008768885", "type": "external" } ], "gene_names_uniprotkb": "Homez", "gene_names_refseq": "Homez", "protein_names_uniprotkb": "Homeobox and leucine zipper protein Homez; Homeodomain leucine zipper-containing factor", "protein_names_refseq": "homeobox and leucine zipper protein Homez isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:260325)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12925734", "class_list": "", "function": "May function as a transcriptional regulator., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K3E9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G074-1", "uniprot_id": [ { "id": "KBP_RAT", "url": "https://www.uniprot.org/uniprot/Q4G074", "type": "external" } ], "mass": 71296.0, "length": 617, "protein_name": "KIF-binding protein", "gene_name": "Kifbp", "organism": "Rat", "refseq_name": "KIF-binding protein", "refseq_ac": [ { "id": "NP_001026797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026797", "type": "external" } ], "gene_names_uniprotkb": "Kifbp; Kbp; Kif1bp", "gene_names_refseq": "Kbp; Kif1bp; Kifbp", "protein_names_uniprotkb": "KIF-binding protein; KIF1-binding protein", "protein_names_refseq": "KIF-binding protein; KIF1 binding protein", "tax_id": 10116, "disease": "Goldberg-Shprintzen syndrome (Disease Ontology:DOID:0060481)", "pathway": " (rno:606294)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20621975", "class_list": "", "function": "Activator of KIF1B plus-end-directed microtubule motor activity (By similarity). Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development (PubMed:20621975)., [UniProtKB, PubMed, UniProtKB]; Activator of KIF1B plus-end-directed microtubule motor activity. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development., [UniProtKB, UniProtKB, UniProtKB]; KBP-depleted PC12 cells were defective in nerve growth factor-induced differentiation and neurite outgrowth, suggesting that KBP is required for cell differentiation and neurite development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005856 cytoskeleton", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0001701 in utero embryonic development;GO:1990535 neuron projection maintenance;GO:0021952 central nervous system projection neuron axonogenesis;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G074-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCU8-1", "uniprot_id": [ { "id": "NDUV3_RAT", "url": "https://www.uniprot.org/uniprot/Q6PCU8", "type": "external" } ], "mass": 11942.0, "length": 108, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial", "gene_name": "Ndufv3-ps1; Ndufv3", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001094481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094481", "type": "external" } ], "gene_names_uniprotkb": "Ndufv3-ps1; Ndufv3; Ndufv3", "gene_names_refseq": "Mipp65; Ndufv3l; Ndufv3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; CI-9kD; Complex I-9kD; NADH-ubiquinone oxidoreductase 9 kDa subunit", "protein_names_refseq": "CI-9kD; NADH dehydrogenase (ubiquinone) flavoprotein 3-like; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 2; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; NADH-ubiquinone oxidoreductase 9 kDa subunit; complex I-9kD", "tax_id": 10116, "disease": "", "pathway": " (rno:64539); (R-RNO-611105); (R-RNO-6799198); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;26686297;27940020", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; OBAP is mainly produced by mitochondria of parietal cells in the upper and lower parts of the gastric epithelium., [RefSeq, PubMed]; We describe characterization of the complexes I purified from five rat tissues and from a rat hepatoma cell line. We identify a~50kDa isoform of subunit NDUFV3, for which the canonical isoform is only ~10kDa in size., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PCU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R518-1", "uniprot_id": [ { "id": "GPN3_RAT", "url": "https://www.uniprot.org/uniprot/Q6R518", "type": "external" } ], "mass": 32802.0, "length": 284, "protein_name": "GPN-loop GTPase 3", "gene_name": "Gpn3", "organism": "Rat", "refseq_name": "GPN-loop GTPase 3 isoform 1", "refseq_ac": [ { "id": "NP_973720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_973720", "type": "external" } ], "gene_names_uniprotkb": "Gpn3; Atpbd1c", "gene_names_refseq": "Atpbd1c; Gpn3", "protein_names_uniprotkb": "GPN-loop GTPase 3; 3.6.5.-; ATP-binding domain 1 family member C", "protein_names_refseq": "ATP-binding domain 1 family member C; GPN-loop GTPase 3 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360810)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Small GTPase involved in the correct assembly of RNA polymerase II complex, ensuring their proper nuclear import of RNAPII., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6R518-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63379-1", "uniprot_id": [ { "id": "MYCN_RAT", "url": "https://www.uniprot.org/uniprot/Q63379", "type": "external" } ], "mass": 49695.0, "length": 462, "protein_name": "N-myc proto-oncogene protein", "gene_name": "Mycn", "organism": "Rat", "refseq_name": "N-myc proto-oncogene protein", "refseq_ac": [ { "id": "NP_001013114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013114", "type": "external" } ], "gene_names_uniprotkb": "Mycn; Nmyc1; Nmyc", "gene_names_refseq": "Mycn; N-myc; Nmuc1; Nmyc", "protein_names_uniprotkb": "N-myc proto-oncogene protein", "protein_names_refseq": "Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc); N-myc proto-oncogene protein; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived", "tax_id": 10116, "disease": "Feingold syndrome (Disease Ontology:DOID:0060464)", "pathway": " (rno:298894)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15331636;1719466;30221657;38407765", "class_list": "", "function": "Data show that nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation., [RefSeq, PubMed]; Positively regulates the transcription of MYCNOS in neuroblastoma cells., [UniProtKB, UniProtKB]; Regulatory role of N-myc downregulated genes in amelogenesis in rats. Review article, [RefSeq, PubMed]; The effects of Huwe1 on Notch1 signaling were completely abolished by knockdown of NMyc, indicating that Huwe1 may require NMyc to suppress the activation of the Notch1 signaling in L2.3 cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0019900 kinase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0071943 Myc-Max complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63379-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXU9-1", "uniprot_id": [ { "id": "PCS1N_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXU9", "type": "external" } ], "mass": 27414.0, "length": 260, "protein_name": "ProSAAS", "gene_name": "Pcsk1n", "organism": "Rat", "refseq_name": "proSAAS precursor", "refseq_ac": [ { "id": "NP_062152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062152", "type": "external" } ], "gene_names_uniprotkb": "Pcsk1n", "gene_names_refseq": "Pcsk1n; Saas", "protein_names_uniprotkb": "ProSAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; SAAS CT(1-49); SAAS CT(25-40); pro-SAAS", "protein_names_refseq": "granin-like neuroendocrine peptide; pro-SAAS; proSAAS precursor; proSAAS-like; proSAAS; proprotein convertase 1 inhibitor", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:246333)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10632593;10816562;11742530;15935061;22673903;9630436", "class_list": "", "function": "Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding., [UniProtKB, UniProtKB]; Endogenous ligand for GPR83. Neuropeptide involved in the regulation of feeding., [UniProtKB, UniProtKB]; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:10816562). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0009409 response to cold;GO:0016486 peptide hormone processing;GO:0002021 response to dietary excess", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QXU9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG12-1", "uniprot_id": [ { "id": "K2C7_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG12", "type": "external" } ], "mass": 50709.0, "length": 457, "protein_name": "Keratin, type II cytoskeletal 7", "gene_name": "Krt7", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 7 isoform 1", "refseq_ac": [ { "id": "NP_001041335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041335", "type": "external" } ], "gene_names_uniprotkb": "Krt7; Kb7; Krt2-7", "gene_names_refseq": "Krt2-7; Krt7", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 7; CK-7; Cytokeratin-7; K7; Keratin-7; Type-II keratin Kb7", "protein_names_refseq": "CK-7; K7; cytokeratin-7; keratin 7, type II; keratin complex 2, basic, gene 7; keratin, type II cytoskeletal 7 isoform 1; keratin, type II cytoskeletal 7; type-II keratin Kb7", "tax_id": 10116, "disease": "pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:300242); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15085952;16641100;22673903;27525410", "class_list": "", "function": "An extensive ductular reaction in advanced Hepatocellular carcinoma (HCC) and a strong correlation between PCK7 and levels of gammaGT and the poor prognosis and aggressiveness of HCC, is reported., [RefSeq, PubMed]; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IG12-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63468-1", "uniprot_id": [ { "id": "KPRA_RAT", "url": "https://www.uniprot.org/uniprot/Q63468", "type": "external" } ], "mass": 39436.0, "length": 356, "protein_name": "Phosphoribosyl pyrophosphate synthase-associated protein 1", "gene_name": "Prpsap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prpsap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoribosyl pyrophosphate synthase-associated protein 1; 39 kDa phosphoribosypyrophosphate synthase-associated protein; PAP39; PRPP synthase-associated protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "X-linked nonsyndromic deafness (Disease Ontology:DOID:0050566); Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210)", "pathway": " (rno:64390)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8132556;8611622", "class_list": "", "function": "Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63417", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0019900 kinase binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033673 negative regulation of kinase activity;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0009165 nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63468-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESG5-1", "uniprot_id": [ { "id": "HS3S1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESG5", "type": "external" } ], "mass": 35810.0, "length": 311, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 1", "gene_name": "Hs3st1", "organism": "Rat", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor", "refseq_ac": [ { "id": "NP_445843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445843", "type": "external" } ], "gene_names_uniprotkb": "Hs3st1; 3ost1; 3ost", "gene_names_refseq": "3OST-I; Hs3st1", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 1; 2.8.2.23; Heparan sulfate 3-O-sulfotransferase 1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1", "protein_names_refseq": "heparan sulfate (glucosamine) 3-O-sulfotransferase 1; heparan sulfate 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; heparan sulfate glucosamine 3-O-sulfotransferase 1 precursor; heparan sulfate glucosamine 3-O-sulfotransferase I", "tax_id": 10116, "disease": "", "pathway": " (rno:84406); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10926552;20500673", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results suggested that HS3ST1 gene expression is strictly regulated by IL-4/IL-13., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.29", "type": "external" }, { "id": "2.8.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.23", "type": "external" } ], "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ESG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESQ9-1", "uniprot_id": [ { "id": "NPVF_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESQ9", "type": "external" } ], "mass": 22979.0, "length": 203, "protein_name": "Pro-FMRFamide-related neuropeptide VF", "gene_name": "Npvf", "organism": "Rat", "refseq_name": "pro-FMRFamide-related neuropeptide VF precursor", "refseq_ac": [ { "id": "NP_076442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076442", "type": "external" } ], "gene_names_uniprotkb": "Npvf; Rfrp", "gene_names_refseq": "Npvf; Rfrp", "protein_names_uniprotkb": "Pro-FMRFamide-related neuropeptide VF; FMRFamide-related peptides; Neuropeptide RFRP-2", "protein_names_refseq": "FMRFamide-related peptides; RFamide-related peptide; pro-FMRFamide-related neuropeptide VF precursor; pro-FMRFamide-related neuropeptide VF", "tax_id": 10116, "disease": "", "pathway": " (rno:60570)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11025660;11481330;11852091;17113584;18628614;25581095;29913425;30307156;32328034;34655735", "class_list": "", "function": "Chronic stress has long-term effects on pregnancy success, even post-stressor, that are mediated by RFRP3.[RFRP3] Publication Status: Online-Only, [RefSeq, PubMed]; Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion. Induces secretion of prolactin., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Endogenous rat RFRP-3 does not affect the timing of puberty in male rats but may be associated with peripubertal rise in growth hormone secretion., [RefSeq, PubMed]; Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus., [RefSeq, PubMed]; RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Role in modulating ovarian physiology in response to sympathetic stress Publication Status: Online-Only, [RefSeq, PubMed]; Study concluded that RFamide-related peptide- (3RFRP-3) plays a regulatory role in male rat reproduction, [RefSeq, PubMed]; These results indicate that RFRP-3 has similar effects on LH as observed with GnIH in avian species; in the rat RFRP-3 has additional roles in regulating feeding and growth., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920A3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0032277 negative regulation of gonadotropin secretion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9ESQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESV1-1", "uniprot_id": [ { "id": "LUZP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESV1", "type": "external" } ], "mass": 117176.0, "length": 1051, "protein_name": "Leucine zipper protein 1", "gene_name": "Luzp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Luzp1; Luzp", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine zipper protein 1; Filamin mechanobinding actin cross-linking protein; Fimbacin; Leucine zipper motif-containing protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:79428)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29393594;8812416", "class_list": "", "function": "F-actin cross-linking protein (By similarity). Stabilizes actin and acts as a negative regulator of primary cilium formation (By similarity). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (By similarity). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (By similarity). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005884 actin filament;GO:0005923 bicellular tight junction", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:1902018 negative regulation of cilium assembly;GO:0060840 artery development;GO:0003281 ventricular septum development;GO:0043149 stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ESV1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q61453-1", "uniprot_id": [ { "id": "IL17_RAT", "url": "https://www.uniprot.org/uniprot/Q61453", "type": "external" } ], "mass": 16877.0, "length": 150, "protein_name": "Interleukin-17A", "gene_name": "Il17a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il17a; Ctla8; Il17", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-17A; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; IL-17A; IL-17", "protein_names_refseq": "", "tax_id": 10116, "disease": "cutaneous lupus erythematosus (Disease Ontology:DOID:0050169); Asperger syndrome (Disease Ontology:DOID:0050432); colitis (Disease Ontology:DOID:0060180); ileitis (Disease Ontology:DOID:0060189); schizophrenia 9 (Disease Ontology:DOID:0070085); COVID-19 (Disease Ontology:DOID:0080600); childhood-onset asthma (Disease Ontology:DOID:0080815); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); leprosy (Disease Ontology:DOID:1024); pleurisy (Disease Ontology:DOID:10247); tuberculoid leprosy (Disease Ontology:DOID:1025); hypertension (Disease Ontology:DOID:10763); lepromatous leprosy (Disease Ontology:DOID:10887); lipoid nephrosis (Disease Ontology:DOID:10966); trachoma (Disease Ontology:DOID:11265); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); autistic disorder (Disease Ontology:DOID:12849); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); melancholic depression (Disease Ontology:DOID:1595); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); psychotic disorder (Disease Ontology:DOID:2468); Mycobacterium avium complex disease (Disease Ontology:DOID:2755); asthma (Disease Ontology:DOID:2841); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); substance-related disorder (Disease Ontology:DOID:303); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); bipolar disorder (Disease Ontology:DOID:3312); periodontal disease (Disease Ontology:DOID:3388); plague (Disease Ontology:DOID:3482); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); acne (Disease Ontology:DOID:6543); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); chronic fatigue syndrome (Disease Ontology:DOID:8544); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:301289)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "8390535;8654948;8877732", "class_list": "", "function": "Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites. In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance. Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation. Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis. As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release. In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 59, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0032747 positive regulation of interleukin-23 production;GO:0006954 inflammatory response;GO:0007219 Notch signaling pathway;GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q61453-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE47-1", "uniprot_id": [ { "id": "ISK6_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE47", "type": "external" } ], "mass": 11667.0, "length": 105, "protein_name": "Serine protease inhibitor Kazal-type 6", "gene_name": "Spink6", "organism": "Rat", "refseq_name": "serine protease inhibitor Kazal-type 6 isoform X1", "refseq_ac": [ { "id": "XP_063133570", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063133570", "type": "external" } ], "gene_names_uniprotkb": "Spink6; Spink5l1", "gene_names_refseq": "Spink5l1; Spink6", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 6", "protein_names_refseq": "serine protease inhibitor Kazal-type 6 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:408235); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045861 negative regulation of proteolysis;GO:1900004 negative regulation of serine-type endopeptidase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE47-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497B8-1", "uniprot_id": [ { "id": "KDM8_RAT", "url": "https://www.uniprot.org/uniprot/Q497B8", "type": "external" } ], "mass": 47247.0, "length": 414, "protein_name": "Bifunctional peptidase and arginyl-hydroxylase JMJD5", "gene_name": "Kdm8", "organism": "Rat", "refseq_name": "bifunctional peptidase and arginyl-hydroxylase JMJD5", "refseq_ac": [ { "id": "NP_001032273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032273", "type": "external" } ], "gene_names_uniprotkb": "Kdm8; Jmjd5", "gene_names_refseq": "Jmjd5; Kdm8; RGD1304823", "protein_names_uniprotkb": "Bifunctional peptidase and arginyl-hydroxylase JMJD5; 1.14.11.73; 3.4.-.-; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8", "protein_names_refseq": "L-arginine (3R)-hydroxylase KDM8; arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; jmjC domain-containing protein 5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; lysine (K)-specific demethylase 8; lysine-specific demethylase 8", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:308976); (R-RNO-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.14.11.73", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.73", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497B8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PXE9-1", "uniprot_id": [ { "id": "IPPK_RAT", "url": "https://www.uniprot.org/uniprot/Q5PXE9", "type": "external" } ], "mass": 55634.0, "length": 489, "protein_name": "Inositol-pentakisphosphate 2-kinase", "gene_name": "Ippk", "organism": "Rat", "refseq_name": "inositol-pentakisphosphate 2-kinase", "refseq_ac": [ { "id": "NP_001008556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008556", "type": "external" } ], "gene_names_uniprotkb": "Ippk", "gene_names_refseq": "C9orf12; Ippk; RGD1311271; rIpk1", "protein_names_uniprotkb": "Inositol-pentakisphosphate 2-kinase; 2.7.1.158; Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase; rIPK1", "protein_names_refseq": "inositol polyphosphate kinase 1; inositol-1,3,4,5,6-pentakisphosphate 2-kinase; inositol-pentakisphosphate 2-kinase; ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:306808); (R-RNO-1855167); (R-RNO-1855191)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15528195", "class_list": "", "function": "Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.158", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.158", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PXE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZY1-1", "uniprot_id": [ { "id": "HRH4_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZY1", "type": "external" } ], "mass": 44023.0, "length": 391, "protein_name": "Histamine H4 receptor", "gene_name": "Hrh4", "organism": "Rat", "refseq_name": "histamine H4 receptor", "refseq_ac": [ { "id": "NP_571984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571984", "type": "external" } ], "gene_names_uniprotkb": "Hrh4", "gene_names_refseq": "Hrh4", "protein_names_uniprotkb": "Histamine H4 receptor; H4R; HH4R", "protein_names_refseq": "H4R; HH4R; histamine H4 receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:170704); (R-RNO-390650); (R-RNO-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "18345490;19046950;19053770;23413254;23488566;25253872;25666529;30528857;31863333", "class_list": "", "function": "Analysis of how quinazolines can act as histamine H4 receptor inverse agonists, [RefSeq, PubMed]; DAO secretion may contribute to the catabolism of histamine released during fat absorption and this is probably mediated through the histamine H(4) receptor., [RefSeq, PubMed]; Data indicate that positive histamine H4 receptor (HRH4) immunostaining was detected in Leydig cells of all testicular sections., [RefSeq, PubMed]; Data show that histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa., [RefSeq, PubMed]; G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma (PubMed:31863333). Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (By similarity). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; H(4) mRNA was detected in cortex, cerebellum, brainstem, amygdala, thalamus & striatum; low levels were detected in hypothalamus, & none was detected in the hippocampus; strong expression of H(4) mRNA was detected in dorsal root ganglion & spinal cord, [RefSeq, PubMed]; H3 and H4 receptors in endothelial cells are potentially important for regulation of blood-brain barrier permeability, including trafficking of immunocompetent cells, [RefSeq, PubMed]; H4R expression increased in a rat model of lipopolysaccharide (LPS)-induced CNS inflammation. Knockdown of H4R in microglia HAPI cells enhanced the production of cytokines following LPS stimulation. Co-immunoprecipitation experiments further revealed an interaction between H4R and tumor necrosis factor receptor-associated factor 6 (TRAF6) in microglia, which was verified both in vivo and in vitro., [RefSeq, PubMed]; The present study found that blocking H4R exerted a significant anti-inflammatory effect at 2 h after Lipopolysaccharide injection and inhibited pro-inflammatory Tumor Necrosis Factor-alpha- and NF-kappaB expression, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006954 inflammatory response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91ZY1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562B4-1", "uniprot_id": [ { "id": "NACC2_RAT", "url": "https://www.uniprot.org/uniprot/Q562B4", "type": "external" } ], "mass": 63100.0, "length": 585, "protein_name": "Nucleus accumbens-associated protein 2", "gene_name": "Nacc2", "organism": "Rat", "refseq_name": "nucleus accumbens-associated protein 2", "refseq_ac": [ { "id": "NP_001094003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094003", "type": "external" } ], "gene_names_uniprotkb": "Nacc2; Btbd14a", "gene_names_refseq": "Btbd14a; Nacc2", "protein_names_uniprotkb": "Nucleus accumbens-associated protein 2; BTB/POZ domain-containing protein 14A; NAC-2", "protein_names_refseq": "BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; NAC-2; NACC family member 2, BEN and BTB (POZ) domain containing; nucleus accumbens associated 2, BEN and BTB (POZ) domain containing; nucleus accumbens-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:296583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q562B4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESM2-1", "uniprot_id": [ { "id": "HPLN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESM2", "type": "external" } ], "mass": 38047.0, "length": 341, "protein_name": "Hyaluronan and proteoglycan link protein 2", "gene_name": "Hapln2", "organism": "Rat", "refseq_name": "hyaluronan and proteoglycan link protein 2 precursor", "refseq_ac": [ { "id": "NP_071621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071621", "type": "external" } ], "gene_names_uniprotkb": "Hapln2; Bral1", "gene_names_refseq": "Bral1; Hapln2", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 2; Brain link protein 1", "protein_names_refseq": "brain link protein 1; hyaluronan and proteoglycan link protein 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:64057)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11027579", "class_list": "", "function": "Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0033268 node of Ranvier;GO:0072534 perineuronal net", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0008065 establishment of blood-nerve barrier", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ESM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZY6-1", "uniprot_id": [ { "id": "HOP2_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZY6", "type": "external" } ], "mass": 24768.0, "length": 217, "protein_name": "Homologous-pairing protein 2 homolog", "gene_name": "Psmc3ip", "organism": "Rat", "refseq_name": "homologous-pairing protein 2 homolog", "refseq_ac": [ { "id": "NP_604453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604453", "type": "external" } ], "gene_names_uniprotkb": "Psmc3ip", "gene_names_refseq": "Gt198; Psmc3ip; Tbpip", "protein_names_uniprotkb": "Homologous-pairing protein 2 homolog; Nuclear receptor coactivator GT198; PSMC3-interacting protein; Proteasome 26S ATPase subunit 3-interacting protein", "protein_names_refseq": "homologous-pairing protein 2 homolog; nuclear receptor coactivator GT198; proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein; proteasome 26S ATPase subunit 3-interacting protein", "tax_id": 10116, "disease": "ovarian dysgenesis 3 (Disease Ontology:DOID:0080495)", "pathway": " (rno:140938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11739747", "class_list": "", "function": "Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0003690 double-stranded DNA binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0120231 DNA recombinase auxiliary factor complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0030521 androgen receptor signaling pathway;GO:0030520 estrogen receptor signaling pathway;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8D9-1", "uniprot_id": [ { "id": "LRC34_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8D9", "type": "external" } ], "mass": 46469.0, "length": 415, "protein_name": "Leucine-rich repeat-containing protein 34", "gene_name": "Lrrc34", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 34", "refseq_ac": [ { "id": "NP_001038161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038161", "type": "external" } ], "gene_names_uniprotkb": "Lrrc34", "gene_names_refseq": "Lrrc34; RGD1565052", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 34", "protein_names_refseq": "leucine-rich repeat-containing protein 34", "tax_id": 10116, "disease": "", "pathway": " (rno:499589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0000723 telomere maintenance;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8D9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK6-1", "uniprot_id": [ { "id": "I13R2_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHK6", "type": "external" } ], "mass": 44622.0, "length": 385, "protein_name": "Interleukin-13 receptor subunit alpha-2", "gene_name": "Il13ra2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il13ra2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2", "protein_names_refseq": "", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); allergic rhinitis (Disease Ontology:DOID:4481); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:171060); (R-RNO-6785807)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12241113", "class_list": "", "function": "Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0071260 cellular response to mechanical stimulus;GO:0019221 cytokine-mediated signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway;GO:0016064 immunoglobulin mediated immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHK6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A20-1", "uniprot_id": [ { "id": "P3IP1_RAT", "url": "https://www.uniprot.org/uniprot/Q56A20", "type": "external" } ], "mass": 29101.0, "length": 267, "protein_name": "Phosphoinositide-3-kinase-interacting protein 1", "gene_name": "Pik3ip1", "organism": "Rat", "refseq_name": "phosphoinositide-3-kinase-interacting protein 1 precursor", "refseq_ac": [ { "id": "NP_001382087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382087", "type": "external" } ], "gene_names_uniprotkb": "Pik3ip1; Hgfl", "gene_names_refseq": "Pik3ip1; RGD1311203; zgc:66482", "protein_names_uniprotkb": "Phosphoinositide-3-kinase-interacting protein 1; Kringle domain-containing protein HGFL", "protein_names_refseq": "HGFL protein; kringle domain-containing protein HGFL; phosphoinositide-3-kinase-interacting protein 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:305472)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0005102 signaling receptor binding;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q56A20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY09-1", "uniprot_id": [ { "id": "HNRH2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY09", "type": "external" } ], "mass": 49294.0, "length": 449, "protein_name": "Heterogeneous nuclear ribonucleoprotein H2", "gene_name": "Hnrnph1; Hnrnph2", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein H2", "refseq_ac": [ { "id": "NP_001014041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014041", "type": "external" } ], "gene_names_uniprotkb": "Hnrnph1; Hnrnph2; Hnrnph2; Hnrph1; Hnrph2", "gene_names_refseq": "Hnrnph2; Hnrph2", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein H2; Heterogeneous nuclear ribonucleoprotein H'; hnRNP H'; hnRNP H2", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein H'; heterogeneous nuclear ribonucleoprotein H2 (H'); heterogeneous nuclear ribonucleoprotein H2; hnRNP H'; hnRNP H2", "tax_id": 10116, "disease": "syndromic X-linked intellectual developmental disorder bain type (Disease Ontology:DOID:0070538)", "pathway": " (rno:308650); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "18573884;27117401", "class_list": "", "function": "HNRNPH is a splicing regulator of Trf2 pre-mRNA that prevents the expression of TRF2-S, a factor implicated in neuronal differentiation., [RefSeq, PubMed]; These results establish hnRNP H and hnRNP F as being repressors of exon inclusion and suggest that Fox proteins enhance their ability to antagonize ASF/SF2., [RefSeq, PubMed]; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY09-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q767I8-1", "uniprot_id": [ { "id": "PCDA4_RAT", "url": "https://www.uniprot.org/uniprot/Q767I8", "type": "external" } ], "mass": 103042.0, "length": 947, "protein_name": "Protocadherin alpha-4", "gene_name": "Pcdha13; Pcdha2; Pcdha4", "organism": "Rat", "refseq_name": "protocadherin alpha-4 precursor", "refseq_ac": [ { "id": "NP_446385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446385", "type": "external" } ], "gene_names_uniprotkb": "Pcdha13; Pcdha2; Pcdha4; Cnrv4; LOC120098166; Pcdha3; Pcdha4; Pcdha5", "gene_names_refseq": "Cnr1; Pcdha10; Pcdha11; Pcdha12; Pcdha13; Pcdha1; Pcdha2; Pcdha3; Pcdha4; Pcdha5; Pcdha6; Pcdha7; Pcdha8; Pcdha9; Pcdhac1; Pcdhac2; cnr5; rCNRv01; rCNRv02; rCNRv03; rCNRv05; rCNRv06; rCNRv07; rCNRv08; rCNRv09; rCNRv10; rCNRv11; rCNRv12; rCNRv13; rCNRvc1; rCNRvc2", "protein_names_uniprotkb": "Protocadherin alpha-4; Cadherin-related neuronal receptor 4; PCDH-alpha-4", "protein_names_refseq": "PCDH-alpha-4; cadherin-related neuronal receptor 10; cadherin-related neuronal receptor 11; cadherin-related neuronal receptor 12; cadherin-related neuronal receptor 13; cadherin-related neuronal receptor 1; cadherin-related neuronal receptor 2; cadherin-related neuronal receptor 3; cadherin-related neuronal receptor 4; cadherin-related neuronal receptor 5; cadherin-related neuronal receptor 6; cadherin-related neuronal receptor 7; cadherin-related neuronal receptor 8; cadherin-related neuronal receptor 9; cadherin-related neuronal receptor c1; cadherin-related neuronal receptor c2; protocadherin alpha 10; protocadherin alpha 11; protocadherin alpha 12; protocadherin alpha 13; protocadherin alpha 1; protocadherin alpha 2; protocadherin alpha 3; protocadherin alpha 5; protocadherin alpha 6; protocadherin alpha 7; protocadherin alpha 8; protocadherin alpha 9; protocadherin alpha c1; protocadherin alpha-4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:116741)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15028293;15240697;38843836", "class_list": "", "function": "Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, UniProtKB]; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5U2Z9;Q8CJ01", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0005634 nucleus", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q767I8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EIC4-1", "uniprot_id": [ { "id": "I2BPL_RAT", "url": "https://www.uniprot.org/uniprot/Q5EIC4", "type": "external" } ], "mass": 81496.0, "length": 783, "protein_name": "Probable E3 ubiquitin-protein ligase IRF2BPL", "gene_name": "Irf2bpl", "organism": "Rat", "refseq_name": "probable E3 ubiquitin-protein ligase IRF2BPL", "refseq_ac": [ { "id": "NP_001012488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012488", "type": "external" } ], "gene_names_uniprotkb": "Irf2bpl; Eap1; Pqcp", "gene_names_refseq": "Eap1; Irf2bpl; Pqcp; RGD1310994", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase IRF2BPL; 2.3.2.27; Enhanced at puberty protein 1; Interferon regulatory factor 2-binding protein-like; Polyglutamine-containing protein", "protein_names_refseq": "enhanced at puberty protein 1; polyglutamine-containing protein; probable E3 ubiquitin-protein ligase IRF2BPL", "tax_id": 10116, "disease": "neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (rno:314329)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17627301;22673903;29017168", "class_list": "", "function": "EAP1 is a transcriptional regulator that, acting within the neuroendocrine brain, contributes to controlling female reproductive function., [RefSeq, PubMed]; Eap1 expression critically regulates puberty as well as GnRH expression. However, Eap1-regulation of puberty may not necessitate KiSS1/GPR54 signaling., [RefSeq, PubMed]; Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4G048", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0046543 development of secondary female sexual characteristics;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5EIC4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P77-1", "uniprot_id": [ { "id": "GTPB4_RAT", "url": "https://www.uniprot.org/uniprot/Q99P77", "type": "external" } ], "mass": 74288.0, "length": 637, "protein_name": "GTP-binding protein 4", "gene_name": "Gtpbp4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gtpbp4; Crfg; Nog1", "gene_names_refseq": "", "protein_names_uniprotkb": "GTP-binding protein 4; Chronic renal failure gene protein; Nucleolar GTP-binding protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:114300)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11316846;22673903", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990275 preribosome binding;GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0042273 ribosomal large subunit biogenesis;GO:0050821 protein stabilization;GO:0022408 negative regulation of cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99P77-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H40-1", "uniprot_id": [ { "id": "HMGN3_RAT", "url": "https://www.uniprot.org/uniprot/Q66H40", "type": "external" } ], "mass": 10183.0, "length": 95, "protein_name": "High mobility group nucleosome-binding domain-containing protein 3", "gene_name": "Hmgn3", "organism": "Rat", "refseq_name": "high mobility group nucleosome-binding domain-containing protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001007021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007021", "type": "external" } ], "gene_names_uniprotkb": "Hmgn3", "gene_names_refseq": "Hmgn3", "protein_names_uniprotkb": "High mobility group nucleosome-binding domain-containing protein 3", "protein_names_refseq": "high mobility group nucleosome binding domain 3; high mobility group nucleosome-binding domain-containing protein 3 isoform 2; high mobility group nucleosome-binding domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:113990)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MYU0-1", "uniprot_id": [ { "id": "OAS2_RAT", "url": "https://www.uniprot.org/uniprot/Q5MYU0", "type": "external" } ], "mass": 84066.0, "length": 733, "protein_name": "2'-5'-oligoadenylate synthase 2", "gene_name": "Oas2", "organism": "Rat", "refseq_name": "2'-5'-oligoadenylate synthase 2", "refseq_ac": [ { "id": "NP_001009715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009715", "type": "external" } ], "gene_names_uniprotkb": "Oas2", "gene_names_refseq": "Oas2", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; 2.7.7.84", "protein_names_refseq": "(2-5')oligo(A) synthase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:363938)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17024523", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (By similarity). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.84", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009617 response to bacterium;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5MYU0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERS0-1", "uniprot_id": [ { "id": "KCNKD_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERS0", "type": "external" } ], "mass": 45081.0, "length": 405, "protein_name": "Potassium channel subfamily K member 13", "gene_name": "Kcnk13", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 13", "refseq_ac": [ { "id": "NP_071629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071629", "type": "external" } ], "gene_names_uniprotkb": "Kcnk13", "gene_names_refseq": "Kcnk13; THIK-1; prdx1", "protein_names_uniprotkb": "Potassium channel subfamily K member 13; THIK-1; Tandem pore domain halothane-inhibited potassium channel 1", "protein_names_refseq": "potassium channel subfamily K member 13; potassium channel, subfamily K, member 13; potassium channel, two pore domain subfamily K, member 13; tandem pore domain halothane-inhibited potassium channel 1; tandem pore domain potassium channel THIK-1", "tax_id": 10116, "disease": "", "pathway": " (rno:64120); (R-RNO-1299287); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11060316;18209473;28676376;29290552;33960499", "class_list": "", "function": "DRG neurons of all sizes express THIK1. Cutaneous inflammation downregulates THIK1 expression in only small DRG neurons., [RefSeq, PubMed]; Inhibiting THIK-1 function depolarizes microglia. Block of THIK-1 function also inhibits release of the pro-inflammatory cytokine interleukin-1beta from activated microglia, consistent with K(+) loss being needed for inflammasome assembly., [RefSeq, PubMed]; K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:11060316). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Contributes most of K(+) currents at the plasma membrane of resting microglia (By similarity). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (By similarity). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity)., [UniProtKB, UniProtKB, PubMed]; KCNK13 potassium channels in the ventral tegmental area of rats are important for excitation of ventral tegmental area neurons by ethanol., [RefSeq, PubMed]; THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1900225 regulation of NLRP3 inflammasome complex assembly;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport;GO:1905810 regulation of excitatory synapse pruning", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ERS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P39-1", "uniprot_id": [ { "id": "NFS1_RAT", "url": "https://www.uniprot.org/uniprot/Q99P39", "type": "external" } ], "mass": 50013.0, "length": 451, "protein_name": "Cysteine desulfurase", "gene_name": "Nfs1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nfs1; Nifs", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine desulfurase; 2.8.1.7", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 52 (Disease Ontology:DOID:0070425)", "pathway": " (rno:84594); (R-RNO-1362409); (R-RNO-947581); (R-RNO-9854311); (R-RNO-9865881)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine desulfurase, of the core iron-sulfur cluster (ISC) assembly complex, that catalyzes the desulfuration of L-cysteine to L-alanine, as component of the cysteine desulfurase complex leading to the formation of a cysteine persulfide intermediate at the active site cysteine residue and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU. The persulfide is then transferred on the flexible Cys loop from the catalytic site of NFS1 to the surface of NFS1 (By similarity). After the NFS1-linked persulfide sulfur is transferred to one of the conserved Cys residues of the scaffold, a reaction assisted by FXN (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May catalyze the desulfuration of L-cysteine to L-alanine as component of the cysteine desulfurase complex (NFS1:LYRM4), leading to the formation of a cysteine persulfide intermediate. Acts as a sulfur donor for MOCS3 by transferring the sulfur of the cysteine persulfide intermediate on MOCS3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0031071 cysteine desulfurase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99P39-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWT0-1", "uniprot_id": [ { "id": "PECA1_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWT0", "type": "external" } ], "mass": 76189.0, "length": 678, "protein_name": "Platelet endothelial cell adhesion molecule", "gene_name": "Pecam1", "organism": "Rat", "refseq_name": "platelet endothelial cell adhesion molecule isoform 2 precursor", "refseq_ac": [ { "id": "NP_113779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113779", "type": "external" } ], "gene_names_uniprotkb": "Pecam1; Pecam", "gene_names_refseq": "CD31; Pecam1; Pecam", "protein_names_uniprotkb": "Platelet endothelial cell adhesion molecule; PECAM-1", "protein_names_refseq": "PECAM-1; platelet endothelial cell adhesion molecule isoform 2 precursor; platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); chronic venous insufficiency (Disease Ontology:DOID:0050853); sickle cell anemia (Disease Ontology:DOID:10923); polycystic ovary syndrome (Disease Ontology:DOID:11612); common variable immunodeficiency (Disease Ontology:DOID:12177); autistic disorder (Disease Ontology:DOID:12849); eosinophilic esophagitis (Disease Ontology:DOID:13922); atherosclerosis (Disease Ontology:DOID:1936); ovarian cancer (Disease Ontology:DOID:2394); orchitis (Disease Ontology:DOID:2518); severe acute respiratory syndrome (Disease Ontology:DOID:2945); neurilemmoma (Disease Ontology:DOID:3192); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); coronary stenosis (Disease Ontology:DOID:4248); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); neuroblastoma (Disease Ontology:DOID:769); varicose veins (Disease Ontology:DOID:799); osteoarthritis (Disease Ontology:DOID:8398); polymyalgia rheumatica (Disease Ontology:DOID:853); chronic myeloid leukemia (Disease Ontology:DOID:8552); myeloid leukemia (Disease Ontology:DOID:8692); bacterial pneumonia (Disease Ontology:DOID:874); psoriatic arthritis (Disease Ontology:DOID:9008); babesiosis (Disease Ontology:DOID:9643)", "pathway": " (rno:29583); (R-RNO-114608); (R-RNO-202733); (R-RNO-210990); (R-RNO-216083); (R-RNO-432142); (R-RNO-6798695)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10878616;22673903;31628816;32437020;38338969", "class_list": "", "function": "Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis., [UniProtKB, UniProtKB, UniProtKB]; Desferoxamine protects against glucocorticoid-induced osteonecrosis of the femoral head via activating HIF-1alpha expression., [RefSeq, PubMed]; Hyperglycemia-induced ubiquitination and degradation of beta-catenin with the loss of platelet endothelial cell adhesion molecule-1 in retinal endothelial cells., [RefSeq, PubMed]; In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRbeta, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "P97635", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042803 protein homodimerization activity;GO:0019903 protein phosphatase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0090673 endothelial cell-matrix adhesion;GO:0061028 establishment of endothelial barrier;GO:0001525 angiogenesis;GO:0006955 immune response;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3SWT0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1H2-1", "uniprot_id": [ { "id": "NGRN_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1H2", "type": "external" } ], "mass": 32951.0, "length": 293, "protein_name": "Neugrin", "gene_name": "Ngrn", "organism": "Rat", "refseq_name": "neugrin precursor", "refseq_ac": [ { "id": "NP_001029072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029072", "type": "external" } ], "gene_names_uniprotkb": "Ngrn", "gene_names_refseq": "Neugrin; Ngrn", "protein_names_uniprotkb": "Neugrin; Neurite outgrowth-associated protein", "protein_names_refseq": "mesenchymal stem cell protein DSC92; neugrin precursor; neurite outgrowth-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:499191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0030154 cell differentiation;GO:0070131 positive regulation of mitochondrial translation;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1J1-1", "uniprot_id": [ { "id": "IF5A1_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1J1", "type": "external" } ], "mass": 16832.0, "length": 154, "protein_name": "Eukaryotic translation initiation factor 5A-1", "gene_name": "Eif5a", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 5A-1", "refseq_ac": [ { "id": "NP_001028853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028853", "type": "external" } ], "gene_names_uniprotkb": "Eif5a", "gene_names_refseq": "Eif5a", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-1; Eukaryotic initiation factor 5A isoform 1; eIF-4D; eIF-5A-1; eIF-5A1; eIF-5A", "protein_names_refseq": "eIF-4D; eIF-5A-1; eIF-5A1; eIF-5A; eukaryotic initiation factor 5A; eukaryotic translation initiation factor 5A-1", "tax_id": 10116, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:287444); (R-RNO-204626)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18606156;19006180;26934977;26964899;28605466;36722231", "class_list": "", "function": "Overexpression or knockdown of miR-434-3p in vivo demonstrated it was a negative post-transcriptional regulator of eIF5A1 expression and influenced AChRs expression. Publication Status: Online-Only, [RefSeq, PubMed]; Secretion of ORAIP in response to oxidative stress is universal mechanism and plays an essential role. ORAIP will be an important novel biomarker as well as a specific therapeutic target of these oxidative stress-induced cell injuries. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the Nucleus Accumbens in the Depression., [RefSeq, PubMed]; The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP., [RefSeq, PubMed]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051149 positive regulation of muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3T1J1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM04-1", "uniprot_id": [ { "id": "IPO13_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM04", "type": "external" } ], "mass": 108187.0, "length": 963, "protein_name": "Importin-13", "gene_name": "Ipo13", "organism": "Rat", "refseq_name": "importin-13", "refseq_ac": [ { "id": "NP_446230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446230", "type": "external" } ], "gene_names_uniprotkb": "Ipo13; Imp13; Lgl2", "gene_names_refseq": "Imp13; Ipo13; Lgl2", "protein_names_uniprotkb": "Importin-13; Imp13; Late gestation lung 2 protein", "protein_names_refseq": "importin-13; late gestation lung 2 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116458)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10745026;16809634;20478346", "class_list": "", "function": "Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems., [RefSeq, PubMed]; Findings support a role for IPO13 in promoting nuclear occupancy of glucocorticoid receptor in a way that strongly potentiates the antiinflammatory effects of glucocorticoids., [RefSeq, PubMed]; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035259 nuclear glucocorticoid receptor binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JM04-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497B3-1", "uniprot_id": [ { "id": "KCP3_RAT", "url": "https://www.uniprot.org/uniprot/Q497B3", "type": "external" } ], "mass": 25897.0, "length": 240, "protein_name": "Keratinocyte-associated protein 3", "gene_name": "Krtcap3", "organism": "Rat", "refseq_name": "keratinocyte-associated protein 3", "refseq_ac": [ { "id": "NP_001103144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103144", "type": "external" } ], "gene_names_uniprotkb": "Krtcap3", "gene_names_refseq": "Krtcap3", "protein_names_uniprotkb": "Keratinocyte-associated protein 3; KCP-3", "protein_names_refseq": "KCP-3; keratinocyte-associated protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:683980)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497B3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498T3-1", "uniprot_id": [ { "id": "ING3_RAT", "url": "https://www.uniprot.org/uniprot/Q498T3", "type": "external" } ], "mass": 46925.0, "length": 421, "protein_name": "Inhibitor of growth protein 3", "gene_name": "Ing3", "organism": "Rat", "refseq_name": "inhibitor of growth protein 3", "refseq_ac": [ { "id": "NP_001029279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029279", "type": "external" } ], "gene_names_uniprotkb": "Ing3", "gene_names_refseq": "Ing3", "protein_names_uniprotkb": "Inhibitor of growth protein 3", "protein_names_refseq": "inhibitor of growth protein 3", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:312154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25151306", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB]; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; ING3 bas a role in inducing cardiomyocyte hypertrophy via inhibition of AMPK and activation of p38 MAPK signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0008270 zinc ion binding;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0032777 piccolo histone acetyltransferase complex;GO:0000786 nucleosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051726 regulation of cell cycle;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498T3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZU2-1", "uniprot_id": [ { "id": "K2C6A_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZU2", "type": "external" } ], "mass": 59249.0, "length": 552, "protein_name": "Keratin, type II cytoskeletal 6A", "gene_name": "Krt6a", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 6A", "refseq_ac": [ { "id": "NP_001094477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094477", "type": "external" } ], "gene_names_uniprotkb": "Krt6a", "gene_names_refseq": "CK-6A; Krt6a; Krt6c", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 6A; CK-6A; Cytokeratin-6A; K6A; Keratin-6A; Type-II keratin Kb6", "protein_names_refseq": "K6a keratin; cytokeratin-6A; keratin K6; keratin, type II cytoskeletal 5-like; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 6A; type-II keratin Kb6", "tax_id": 10116, "disease": "pachyonychia congenita (Disease Ontology:DOID:0050449); focal or diffuse nonepidermolytic palmoplantar keratoderma (Disease Ontology:DOID:0111710)", "pathway": " (rno:683313); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "34502162;38843836;41018975", "class_list": "", "function": "Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins KRT16 and KRT17, assembling into keratin intermediate filament networks that contributes to the structural integrity and stress resilience of stratified epithelia, particularly in epidermis, nail bed and oral mucosa (By similarity). Rapidly induced in wound-edge keratinocytes and participates in cytoskeletal reorganization during re-epithelialization. Negatively regulates collective keratinocyte migration by stabilizing non-muscle myosin MYH9 and desmoplakin, thereby altering cell-cell and cell-matrix adhesion and reducing the speed and directionality of epithelial sheet movement during wound repair. Also limits epithelial migration by inhibiting SRC activity during wound repair (By similarity). Required for normal palmoplantar, nail unit and oral mucosa integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization;GO:0042060 wound healing;GO:0045104 intermediate filament cytoskeleton organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4FZU2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZV3-1", "uniprot_id": [ { "id": "IDLC_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZV3", "type": "external" } ], "mass": 29622.0, "length": 258, "protein_name": "Axonemal dynein light intermediate polypeptide 1", "gene_name": "Dnali1", "organism": "Rat", "refseq_name": "axonemal dynein light intermediate polypeptide 1", "refseq_ac": [ { "id": "NP_001026817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026817", "type": "external" } ], "gene_names_uniprotkb": "Dnali1", "gene_names_refseq": "Dnali1", "protein_names_uniprotkb": "Axonemal dynein light intermediate polypeptide 1; Inner dynein arm light chain, axonemal", "protein_names_refseq": "axonemal dynein light intermediate polypeptide 1; dynein, axonemal, light intermediate polypeptide 1; inner dynein arm light chain, axonemal", "tax_id": 10116, "disease": "spermatogenic failure 83 (Disease Ontology:DOID:0070582)", "pathway": " (rno:298524)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in sperm flagellum assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0030175 filopodium", "go_biological_process": "GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZV3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G017-1", "uniprot_id": [ { "id": "NISCH_RAT", "url": "https://www.uniprot.org/uniprot/Q4G017", "type": "external" } ], "mass": 166503.0, "length": 1502, "protein_name": "Nischarin", "gene_name": "Nisch", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nisch", "gene_names_refseq": "", "protein_names_uniprotkb": "Nischarin; I-1; I1R; IR1; Imidazoline receptor 1; Imidazoline-1 receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:306255); (R-RNO-9013149); (R-RNO-9696264); (R-RNO-9696270)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11274989;15901801;17254010;17940198;29393594", "class_list": "", "function": "Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Also inhibits LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis (By similarity). Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3 (By similarity). When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0048243 norepinephrine secretion;GO:0006915 apoptotic process;GO:0008217 regulation of blood pressure;GO:0030336 negative regulation of cell migration;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4G017-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLI9-1", "uniprot_id": [ { "id": "FBXW5_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLI9", "type": "external" } ], "mass": 64034.0, "length": 569, "protein_name": "F-box/WD repeat-containing protein 5", "gene_name": "Fbxw5", "organism": "Rat", "refseq_name": "F-box/WD repeat-containing protein 5", "refseq_ac": [ { "id": "NP_001020901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020901", "type": "external" } ], "gene_names_uniprotkb": "Fbxw5", "gene_names_refseq": "Fbxw5", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5", "protein_names_refseq": "F-box and WD-40 domain protein 5; F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:362081); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24444419;31060780;32971071", "class_list": "", "function": "FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway., [RefSeq, PubMed]; FBXW5 reduction alleviates spinal cord injury by blocking microglia activity and down-regulating p38 and JNK., [RefSeq, PubMed]; Oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2, [RefSeq, PubMed]; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F8WFL5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0007088 regulation of mitotic nuclear division;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4KLI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLM4-1", "uniprot_id": [ { "id": "KLH25_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLM4", "type": "external" } ], "mass": 65840.0, "length": 589, "protein_name": "Kelch-like protein 25", "gene_name": "Klhl25", "organism": "Rat", "refseq_name": "kelch-like protein 25", "refseq_ac": [ { "id": "NP_001034095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034095", "type": "external" } ], "gene_names_uniprotkb": "Klhl25", "gene_names_refseq": "Klhl25; RGD1310815", "protein_names_uniprotkb": "Kelch-like protein 25", "protein_names_refseq": "ENC-2; ectoderm-neural cortex protein 2; kelch-like 25; kelch-like protein 25", "tax_id": 10116, "disease": "", "pathway": " (rno:293023); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0016567 protein ubiquitination;GO:0006446 regulation of translational initiation;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLN4-1", "uniprot_id": [ { "id": "GLE1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLN4", "type": "external" } ], "mass": 79492.0, "length": 698, "protein_name": "mRNA export factor GLE1", "gene_name": "Gle1", "organism": "Rat", "refseq_name": "mRNA export factor GLE1", "refseq_ac": [ { "id": "NP_001020902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020902", "type": "external" } ], "gene_names_uniprotkb": "Gle1; Gle1l", "gene_names_refseq": "Gle1l; Gle1", "protein_names_uniprotkb": "mRNA export factor GLE1; GLE1 RNA export mediator; GLE1-like protein; Nucleoporin GLE1", "protein_names_refseq": "GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like (yeast; GLE1-like protein; mRNA export factor GLE1; nucleoporin GLE1", "tax_id": 10116, "disease": "lethal congenital contracture syndrome 1 (Disease Ontology:DOID:0060559)", "pathway": " (rno:362098); (R-RNO-159236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0000822 inositol hexakisphosphate binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLN4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM32-1", "uniprot_id": [ { "id": "MUS81_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM32", "type": "external" } ], "mass": 61903.0, "length": 551, "protein_name": "Structure-specific endonuclease subunit MUS81", "gene_name": "Mus81", "organism": "Rat", "refseq_name": "structure-specific endonuclease subunit MUS81", "refseq_ac": [ { "id": "NP_001020816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020816", "type": "external" } ], "gene_names_uniprotkb": "Mus81", "gene_names_refseq": "Mus81", "protein_names_uniprotkb": "Structure-specific endonuclease subunit MUS81; 3.1.22.-; Crossover junction endonuclease MUS81", "protein_names_refseq": "MUS81 endonuclease homolog; crossover junction endonuclease MUS81; structure-specific endonuclease subunit MUS81", "tax_id": 10116, "disease": "arterial tortuosity syndrome (Disease Ontology:DOID:0050645); Marfan syndrome (Disease Ontology:DOID:14323); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:293678); (R-RNO-5693568); (R-RNO-6783310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of two functionally distinct, structure-specific, heterodimeric DNA endonucleases MUS81-EME1 and MUS81-EME2 that are involved in the maintenance of genome stability. Both endonucleases have essentially the same substrate specificity though MUS81-EME2 is more active than its MUS81-EME1 counterpart. Both cleave 3'-flaps and nicked Holliday junctions, and exhibit limited endonuclease activity with 5' flaps and nicked double-stranded DNAs. MUS81-EME2 which is active during the replication of DNA is more specifically involved in replication fork processing. Replication forks frequently encounter obstacles to their passage, including DNA base lesions, DNA interstrand cross-links, difficult-to-replicate sequences, transcription bubbles, or tightly bound proteins. One mechanism for the restart of a stalled replication fork involves nucleolytic cleavage mediated by the MUS81-EME2 endonuclease. By acting upon the stalled fork, MUS81-EME2 generates a DNA double-strand break (DSB) that can be repaired by homologous recombination, leading to the restoration of an active fork. MUS81-EME2 could also function in telomere maintenance. MUS81-EME1, on the other hand, is active later in the cell cycle and functions in the resolution of mitotic recombination intermediates including the Holliday junctions, the four-way DNA intermediates that form during homologous recombination., [UniProtKB, UniProtKB]; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0001650 fibrillar center;GO:0005657 replication fork;GO:0048476 Holliday junction resolvase complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0033687 osteoblast proliferation;GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM32-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQS0-1", "uniprot_id": [ { "id": "IRAK2_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQS0", "type": "external" } ], "mass": 69237.0, "length": 624, "protein_name": "Interleukin-1 receptor-associated kinase-like 2", "gene_name": "Irak2", "organism": "Rat", "refseq_name": "interleukin-1 receptor-associated kinase-like 2", "refseq_ac": [ { "id": "NP_001020593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020593", "type": "external" } ], "gene_names_uniprotkb": "Irak2", "gene_names_refseq": "Irak2", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase-like 2; IRAK-2", "protein_names_refseq": "IRAK-2; interleukin-1 receptor-associated kinase-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362418); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-9020702); (R-RNO-937042); (R-RNO-937072); (R-RNO-975163)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "18996842;19103603;26394923;29393594", "class_list": "", "function": "Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization., [UniProtKB, UniProtKB, UniProtKB]; Elevated circulating IL-1beta contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in diabetic cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Irak2 increases ~ 15-fold at night in the rat pineal gland, as a result of adrenergic-cyclic AMP signalling. Night time levels are >15-fold greater than median expression levels in other tissues., [RefSeq, PubMed]; TRAF6 and interleukin receptor-associated kinase 2 are novel binding partners for PS1, and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0070555 response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QQS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQT5-1", "uniprot_id": [ { "id": "IDHG2_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQT5", "type": "external" } ], "mass": 43568.0, "length": 395, "protein_name": "Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "gene_name": "", "organism": "Rat", "refseq_name": "probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "refseq_ac": [ { "id": "NP_001096833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096833", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "4933405O20Rikl", "protein_names_uniprotkb": "Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Isocitric dehydrogenase subunit gamma 2; NAD(+)-specific ICDH subunit gamma 2", "protein_names_refseq": "NAD(+)-specific ICDH subunit gamma 2; isocitric dehydrogenase subunit gamma 2; probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial-like; probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (rno:100125384)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQT5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQW3-1", "uniprot_id": [ { "id": "HOT_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQW3", "type": "external" } ], "mass": 50226.0, "length": 467, "protein_name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "gene_name": "Adhfe1", "organism": "Rat", "refseq_name": "hydroxyacid-oxoacid transhydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001020594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020594", "type": "external" } ], "gene_names_uniprotkb": "Adhfe1", "gene_names_refseq": "Adhfe1", "protein_names_uniprotkb": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial; 1.1.99.24; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; HOT", "protein_names_refseq": "HOT; alcohol dehydrogenase iron-containing protein 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:362474); (R-RNO-880009)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;3182820", "class_list": "", "function": "Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.99.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.24", "type": "external" } ], "go_molecular_function": "GO:0047988 hydroxyacid-oxoacid transhydrogenase activity;GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046952 ketone body catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4QQW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V886-1", "uniprot_id": [ { "id": "PAF1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V886", "type": "external" } ], "mass": 60546.0, "length": 535, "protein_name": "RNA polymerase II-associated factor 1 homolog", "gene_name": "Paf1", "organism": "Rat", "refseq_name": "RNA polymerase II-associated factor 1 homolog", "refseq_ac": [ { "id": "NP_001020069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020069", "type": "external" } ], "gene_names_uniprotkb": "Paf1", "gene_names_refseq": "Paf1; RGD1306219", "protein_names_uniprotkb": "RNA polymerase II-associated factor 1 homolog", "protein_names_refseq": "PAF1 homolog, Paf1/RNA polymerase II complex component; Paf1, RNA polymerase II associated factor, homolog; RNA polymerase II-associated factor 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361531); (R-RNO-112382); (R-RNO-674695); (R-RNO-75955); (R-RNO-8866654); (R-RNO-9943411)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Connects PAF1C with the RNF20/40 E3 ubiquitin-protein ligase complex. Involved in polyadenylation of mRNA precursors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0016055 Wnt signaling pathway;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V886-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8A1-1", "uniprot_id": [ { "id": "PCT2B_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8A1", "type": "external" } ], "mass": 58563.0, "length": 517, "protein_name": "Lysophosphatidylcholine acyltransferase 2B", "gene_name": "Lpcat2b", "organism": "Rat", "refseq_name": "lysophosphatidylcholine acyltransferase 2B", "refseq_ac": [ { "id": "NP_001020802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020802", "type": "external" } ], "gene_names_uniprotkb": "Lpcat2b; Aytl1b", "gene_names_refseq": "Aytl1b; Lpcat2bp; Lpcat2b; RGD1310837", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2B; 2.3.1.-; Acyltransferase-like 1-B", "protein_names_refseq": "acyltransferase like 1B; acyltransferase-like 1-B; lysophosphatidylcholine acyltransferase 2-B; lysophosphatidylcholine acyltransferase 2B", "tax_id": 10116, "disease": "", "pathway": " (rno:289439)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable acetyltransferase., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8A1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B7-1", "uniprot_id": [ { "id": "HSDL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B7", "type": "external" } ], "mass": 36908.0, "length": 330, "protein_name": "Inactive hydroxysteroid dehydrogenase-like protein 1", "gene_name": "Hsdl1", "organism": "Rat", "refseq_name": "inactive hydroxysteroid dehydrogenase-like protein 1", "refseq_ac": [ { "id": "NP_001020067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020067", "type": "external" } ], "gene_names_uniprotkb": "Hsdl1", "gene_names_refseq": "Hsdl1; RGD1308433", "protein_names_uniprotkb": "Inactive hydroxysteroid dehydrogenase-like protein 1", "protein_names_refseq": "inactive hydroxysteroid dehydrogenase-like protein 1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:361418)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8B7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8I7-1", "uniprot_id": [ { "id": "LRC8A_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8I7", "type": "external" } ], "mass": 94162.0, "length": 810, "protein_name": "Volume-regulated anion channel subunit LRRC8A", "gene_name": "Lrrc8a", "organism": "Rat", "refseq_name": "volume-regulated anion channel subunit LRRC8A", "refseq_ac": [ { "id": "NP_001019953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019953", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8a; Lrrc8; SWELL1", "gene_names_refseq": "Lrrc8a; Lrrc8", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8A; Leucine-rich repeat-containing protein 8A; Swelling protein 1 SWELL1", "protein_names_refseq": "leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; swelling protein 1 SWELL1; volume-regulated anion channel subunit LRRC8A", "tax_id": 10116, "disease": "agammaglobulinemia 5 (Disease Ontology:DOID:0080588); agammaglobulinemia (Disease Ontology:DOID:2583)", "pathway": " (rno:311846); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;28833202;31421089;34725866;38843836", "class_list": "", "function": "Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:28833202). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). In complex with LRRC8C or LRRC8E, acts as a transporter of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol: mediates both import and export of 2'-3'-cGAMP, thereby promoting transfer of 2'-3'-cGAMP to bystander cells (By similarity). In contrast, complexes containing LRRC8D inhibit transport of 2'-3'-cGAMP (By similarity). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (By similarity). Also required for T-cell development (By similarity). Required for myoblast differentiation: VRAC activity promotes membrane hyperpolarization and regulates insulin-stimulated glucose metabolism and oxygen consumption (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (By similarity). Acts as a key factor in NLRP3 inflammasome activation by modulating itaconate efflux and mitochondria function (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension., [RefSeq, PubMed]; LRRC8A plays an essential role in the progression of AFC in LPS-induced acute lung injury, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity;GO:0042802 identical protein binding;GO:0140360 cyclic-GMP-AMP transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0006970 response to osmotic stress;GO:0007283 spermatogenesis;GO:0032024 positive regulation of insulin secretion;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q4V8I7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8J4-1", "uniprot_id": [ { "id": "GPAT3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8J4", "type": "external" } ], "mass": 51012.0, "length": 457, "protein_name": "Glycerol-3-phosphate acyltransferase 3", "gene_name": "Gpat3", "organism": "Rat", "refseq_name": "glycerol-3-phosphate acyltransferase 3", "refseq_ac": [ { "id": "NP_001020841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020841", "type": "external" } ], "gene_names_uniprotkb": "Gpat3; Agpat9", "gene_names_refseq": "AGPAT 10; Agpat9; Gpat3", "protein_names_uniprotkb": "Glycerol-3-phosphate acyltransferase 3; 1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 2.3.1.15; 2.3.1.51; AGPAT 10; GPAT-3; LPAAT-theta; Lysophosphatidic acid acyltransferase theta", "protein_names_refseq": "1-AGP acyltransferase 9; 1-AGPAT 9; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10; 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9; 1-acylglycerol-3-phosphate O-acyltransferase 9; GPAT-3; LPAAT-theta; glycerol-3-phosphate acyltransferase 3; lysophosphatidic acid acyltransferase theta", "tax_id": 10116, "disease": "", "pathway": " (rno:305166); (R-RNO-1483166)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Protects cells against lipotoxicity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366 glycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0032006 regulation of TOR signaling;GO:0008654 phospholipid biosynthetic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8J4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q53E76-1", "uniprot_id": [ { "id": "QTMAN_RAT", "url": "https://www.uniprot.org/uniprot/Q53E76", "type": "external" } ], "mass": 44657.0, "length": 389, "protein_name": "tRNA-queuosine alpha-mannosyltransferase", "gene_name": "Qtman", "organism": "Rat", "refseq_name": "tRNA-queuosine alpha-mannosyltransferase isoform 2", "refseq_ac": [ { "id": "NP_001019445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019445", "type": "external" } ], "gene_names_uniprotkb": "Qtman; Gtdc1", "gene_names_refseq": "Gtdc1; Qtman", "protein_names_uniprotkb": "tRNA-queuosine alpha-mannosyltransferase; 2.4.1.110; Glycosyltransferase-like domain-containing protein 1; QTMAN", "protein_names_refseq": "glycosyltransferase-like domain containing 1; glycosyltransferase-like domain-containing protein 1; glycosyltransferase-like protein; tRNA-queuosine alpha-mannosyltransferase isoform 2; tRNA-queuosine alpha-mannosyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:362129)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "37992713", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that specifically catalyzes mannosylation of cytoplasmic tRNA(Asp) modified with queuosine at position 34 (queuosine(34)) (PubMed:37992713). Mannosylates the cyclopentene moiety of queuosine(34) in tRNA(Asp) to form mannosyl-queuosine(34) (PubMed:37992713). Mannosylation of queuosine(34) in tRNA(Asp) is required to slow-down elongation at cognate codons, GAC and GAU, thereby regulating protein translation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.110", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.110", "type": "external" } ], "go_molecular_function": "GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0006400 tRNA modification;GO:0002099 tRNA wobble guanine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q53E76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566R3-1", "uniprot_id": [ { "id": "GPTC4_RAT", "url": "https://www.uniprot.org/uniprot/Q566R3", "type": "external" } ], "mass": 46073.0, "length": 407, "protein_name": "G patch domain-containing protein 4", "gene_name": "Gpatch4", "organism": "Rat", "refseq_name": "G patch domain-containing protein 4", "refseq_ac": [ { "id": "NP_001020150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020150", "type": "external" } ], "gene_names_uniprotkb": "Gpatch4; Gpatc4", "gene_names_refseq": "Gpatch4; RGD1311086", "protein_names_uniprotkb": "G patch domain-containing protein 4", "protein_names_refseq": "G patch domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:295228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q566R3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56R16-1", "uniprot_id": [ { "id": "IMA6_RAT", "url": "https://www.uniprot.org/uniprot/Q56R16", "type": "external" } ], "mass": 60632.0, "length": 539, "protein_name": "Importin subunit alpha-6", "gene_name": "Kpna5", "organism": "Rat", "refseq_name": "importin subunit alpha-6", "refseq_ac": [ { "id": "NP_001020284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020284", "type": "external" } ], "gene_names_uniprotkb": "Kpna5", "gene_names_refseq": "Ipoa6; Kpna5", "protein_names_uniprotkb": "Importin subunit alpha-6; Karyopherin subunit alpha-5", "protein_names_refseq": "importin subunit alpha-6; karyopherin alpha 5 (importin alpha 6)", "tax_id": 10116, "disease": "", "pathway": " (rno:294392)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16906019", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9 (By similarity)., [UniProtKB]; Functions in nuclear protein import., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHW5", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0042564 NLS-dependent protein nuclear import complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q56R16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56UD9-1", "uniprot_id": [ { "id": "NPBW1_RAT", "url": "https://www.uniprot.org/uniprot/Q56UD9", "type": "external" } ], "mass": 36306.0, "length": 329, "protein_name": "Neuropeptides B/W receptor type 1", "gene_name": "Npbwr1", "organism": "Rat", "refseq_name": "neuropeptides B/W receptor type 1", "refseq_ac": [ { "id": "NP_001014784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014784", "type": "external" } ], "gene_names_uniprotkb": "Npbwr1; Gpr7", "gene_names_refseq": "Gpr7; Nbpwr1; Npbwr1", "protein_names_uniprotkb": "Neuropeptides B/W receptor type 1; G protein-coupled receptor 7", "protein_names_refseq": "G-protein coupled receptor 7; GRP7; neuropeptides B/W receptor 1; neuropeptides B/W receptor type 1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:297795); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16736466;33105700", "class_list": "", "function": "Demonstrates the expression patterns of GPR7, NPB, and NPW precursor messenger ribonucleic acid (mRNA) in the rat brain by using in situ hybridization and in situ binding experiments, [RefSeq, PubMed]; Identification of NPB, NPW and Their Receptor in the Rat Heart. Publication Status: Online-Only, [RefSeq, PubMed]; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q56UD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJW5-1", "uniprot_id": [ { "id": "LUR1L_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJW5", "type": "external" } ], "mass": 23668.0, "length": 221, "protein_name": "Leucine rich adaptor protein 1-like", "gene_name": "Lurap1l", "organism": "Rat", "refseq_name": "leucine rich adaptor protein 1-like", "refseq_ac": [ { "id": "NP_001020193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020193", "type": "external" } ], "gene_names_uniprotkb": "Lurap1l", "gene_names_refseq": "Lurap1l; RGD1308059", "protein_names_uniprotkb": "Leucine rich adaptor protein 1-like", "protein_names_refseq": "leucine rich adaptor protein 1-like; uncharacterized protein C9orf150 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362535)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJY3-1", "uniprot_id": [ { "id": "IN80C_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJY3", "type": "external" } ], "mass": 20424.0, "length": 191, "protein_name": "INO80 complex subunit C", "gene_name": "Ino80c", "organism": "Rat", "refseq_name": "INO80 complex subunit C isoform 1", "refseq_ac": [ { "id": "NP_001017446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017446", "type": "external" } ], "gene_names_uniprotkb": "Ino80c", "gene_names_refseq": "Ino80c; RGD1310199", "protein_names_uniprotkb": "INO80 complex subunit C", "protein_names_refseq": "INO80 complex subunit C isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:291737); (R-RNO-5689603); (R-RNO-5696394)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031011 Ino80 complex;GO:0001650 fibrillar center;GO:0071339 MLL1 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJY3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJY6-1", "uniprot_id": [ { "id": "NAGA_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJY6", "type": "external" } ], "mass": 43539.0, "length": 409, "protein_name": "N-acetylglucosamine-6-phosphate deacetylase", "gene_name": "Amdhd2", "organism": "Rat", "refseq_name": "N-acetylglucosamine-6-phosphate deacetylase", "refseq_ac": [ { "id": "NP_001020161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020161", "type": "external" } ], "gene_names_uniprotkb": "Amdhd2", "gene_names_refseq": "Amdhd2; RGD1304601", "protein_names_uniprotkb": "N-acetylglucosamine-6-phosphate deacetylase; 3.5.1.25; Amidohydrolase domain-containing protein 2; GlcNAc 6-P deacetylase", "protein_names_refseq": "N-acetylglucosamine-6-phosphate deacetylase; amidohydrolase domain-containing protein 2; glcNAc 6-P deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase", "tax_id": 10116, "disease": "", "pathway": " (rno:302972); (R-RNO-446210)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.25", "type": "external" } ], "go_molecular_function": "GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0019262 N-acetylneuraminate catabolic process;GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process;GO:0006044 N-acetylglucosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK60-1", "uniprot_id": [ { "id": "KLH38_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK60", "type": "external" } ], "mass": 65672.0, "length": 580, "protein_name": "Kelch-like protein 38", "gene_name": "Klhl38", "organism": "Rat", "refseq_name": "kelch-like protein 38", "refseq_ac": [ { "id": "NP_001020179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020179", "type": "external" } ], "gene_names_uniprotkb": "Klhl38", "gene_names_refseq": "Klhl38", "protein_names_uniprotkb": "Kelch-like protein 38", "protein_names_refseq": "kelch-like 38; kelch-like protein 38", "tax_id": 10116, "disease": "", "pathway": " (rno:314996)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK65-1", "uniprot_id": [ { "id": "LRC33_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK65", "type": "external" } ], "mass": 77070.0, "length": 692, "protein_name": "Transforming growth factor beta activator LRRC33", "gene_name": "Nrros", "organism": "Rat", "refseq_name": "transforming growth factor beta activator LRRC33 precursor", "refseq_ac": [ { "id": "NP_001020166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020166", "type": "external" } ], "gene_names_uniprotkb": "Nrros; Lrrc33", "gene_names_refseq": "Garpl1; Lrrc33; Nrros; RGD1310771", "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33^; Negative regulator of reactive oxygen species", "protein_names_refseq": "leucine rich repeat containing 33; leucine-rich repeat-containing protein 33^; leucine-rich repeat-containing protein 33; transforming growth factor beta activator LRRC33 precursor; transforming growth factor beta activator LRRC33", "tax_id": 10116, "disease": "", "pathway": " (rno:303875)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035583 sequestering of TGFbeta in extracellular matrix;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0014005 microglia development;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63264-1", "uniprot_id": [ { "id": "IL1B_RAT", "url": "https://www.uniprot.org/uniprot/Q63264", "type": "external" } ], "mass": 30644.0, "length": 268, "protein_name": "Interleukin-1 beta", "gene_name": "Il1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il1b; IL1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-1 beta; IL-1 beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); obstructive sleep apnea (Disease Ontology:DOID:0050848); glomerulosclerosis (Disease Ontology:DOID:0050851); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); myelodysplastic syndrome (Disease Ontology:DOID:0050908); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); urinary tract infection (Disease Ontology:DOID:0080784); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); keratoconus (Disease Ontology:DOID:10126); dry eye syndrome (Disease Ontology:DOID:10140); thalassemia (Disease Ontology:DOID:10241); pleurisy (Disease Ontology:DOID:10247); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); hydronephrosis (Disease Ontology:DOID:11111); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); Graves' disease (Disease Ontology:DOID:12361); paracoccidioidomycosis (Disease Ontology:DOID:12662); agranulocytosis (Disease Ontology:DOID:12987); retinopathy of prematurity (Disease Ontology:DOID:13025); crescentic glomerulonephritis (Disease Ontology:DOID:13139); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); anodontia (Disease Ontology:DOID:13714); hypolipoproteinemia (Disease Ontology:DOID:1387); polyneuropathy (Disease Ontology:DOID:1389); Parkinson's disease (Disease Ontology:DOID:14330); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); thrombocytopenia (Disease Ontology:DOID:1588); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); hepatitis C (Disease Ontology:DOID:1883); dental caries (Disease Ontology:DOID:216); thrombocytosis (Disease Ontology:DOID:2228); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); bronchiolitis (Disease Ontology:DOID:2942); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastric adenocarcinoma (Disease Ontology:DOID:3717); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); hyperglycemia (Disease Ontology:DOID:4195); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); endophthalmitis (Disease Ontology:DOID:4692); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); cochlear disease (Disease Ontology:DOID:5463); pneumonia (Disease Ontology:DOID:552); eye disease (Disease Ontology:DOID:5614); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); extrinsic allergic alveolitis (Disease Ontology:DOID:841); lung disease (Disease Ontology:DOID:850); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); cholesteatoma (Disease Ontology:DOID:869); vascular dementia (Disease Ontology:DOID:8725); bacterial pneumonia (Disease Ontology:DOID:874); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); status asthmaticus (Disease Ontology:DOID:9362); epididymitis (Disease Ontology:DOID:9402); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); bronchiectasis (Disease Ontology:DOID:9563); encephalitis (Disease Ontology:DOID:9588); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24494); (R-RNO-448706); (R-RNO-5620971); (R-RNO-5660668); (R-RNO-9020702)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "23955712;29393594", "class_list": "", "function": "Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 125, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0030141 secretory granule;GO:0005764 lysosome", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0070164 negative regulation of adiponectin secretion;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0070498 interleukin-1-mediated signaling pathway;GO:0050691 regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63264-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EBA8-1", "uniprot_id": [ { "id": "PCFT_RAT", "url": "https://www.uniprot.org/uniprot/Q5EBA8", "type": "external" } ], "mass": 50095.0, "length": 459, "protein_name": "Proton-coupled folate transporter", "gene_name": "Slc46a1", "organism": "Rat", "refseq_name": "proton-coupled folate transporter", "refseq_ac": [ { "id": "NP_001013991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013991", "type": "external" } ], "gene_names_uniprotkb": "Slc46a1; Hcp1; Pcft", "gene_names_refseq": "RGD1309472; Slc46a1; rPCFT", "protein_names_uniprotkb": "Proton-coupled folate transporter; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1; rPCFT", "protein_names_refseq": "PCFT/HCP1; heme carrier protein 1; proton-coupled folate transporter; solute carrier family 46 (folate transporter), member 1", "tax_id": 10116, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); carotid artery disease (Disease Ontology:DOID:3407); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:303333); (R-RNO-196757); (R-RNO-917937); (R-RNO-9707616)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "16143108;17898134;18174275;21454685;22163044;28720846;31792273;35811443", "class_list": "", "function": "Decreased levels of PCFT and RFC expression in rat PPM are due to decreased association of these proteins with lipid rafts (LR) at the PPM, [RefSeq, PubMed]; Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma., [RefSeq, PubMed]; Physiological stress could increase heme uptake via heme carrier protein 1 (HCP1) in brains through a transcription factor, Kruppel-like factor 4 (KLF4). Publication Status: Online-Only, [RefSeq, PubMed]; Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:18174275, PubMed:31792273). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:18174275). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (PubMed:18174275). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (By similarity). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Slc46a1/PCFT plays critical role in intestinal folate absorption., [RefSeq, PubMed]; We provide several lines of evidence that indicate PCFT/HCP1 has a role as the molecular entity of the intestinal folate transport system., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015232 heme transmembrane transporter activity;GO:0015293 symporter activity;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0055085 transmembrane transport;GO:0015886 heme transport;GO:0015884 folic acid transport;GO:0098838 folate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5EBA8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVL2-1", "uniprot_id": [ { "id": "EMC8_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVL2", "type": "external" } ], "mass": 23406.0, "length": 207, "protein_name": "ER membrane protein complex subunit 8", "gene_name": "Emc8", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 8", "refseq_ac": [ { "id": "NP_001012165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012165", "type": "external" } ], "gene_names_uniprotkb": "Emc8; Cox4nb", "gene_names_refseq": "Cox4nb; DD6A4-2(5); Emc8; Noc4", "protein_names_uniprotkb": "ER membrane protein complex subunit 8; Neighbor of COX4", "protein_names_refseq": "COX4 neighbor; ER membrane protein complex subunit 8; neighbor of Cox4", "tax_id": 10116, "disease": "", "pathway": " (rno:361425)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVL2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVM4-1", "uniprot_id": [ { "id": "NONO_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVM4", "type": "external" } ], "mass": 54925.0, "length": 476, "protein_name": "Non-POU domain-containing octamer-binding protein", "gene_name": "Nono", "organism": "Rat", "refseq_name": "non-POU domain-containing octamer-binding protein", "refseq_ac": [ { "id": "NP_001012356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012356", "type": "external" } ], "gene_names_uniprotkb": "Nono", "gene_names_refseq": "Nono", "protein_names_uniprotkb": "Non-POU domain-containing octamer-binding protein; NonO protein", "protein_names_refseq": "non-POU domain-containing octamer-binding protein", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); syndromic X-linked intellectual disability 34 (Disease Ontology:DOID:0060817); aortic dissection (Disease Ontology:DOID:0080685); intellectual disability (Disease Ontology:DOID:1059); atherosclerosis (Disease Ontology:DOID:1936); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:317259)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15860628;37130848;38843836", "class_list": "", "function": "DNA- and RNA binding protein, involved in several nuclear processes (By similarity). Binds the conventional octamer sequence in double-stranded DNA (By similarity). Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ (By similarity). Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b (By similarity). Together with PSPC1, required for the formation of nuclear paraspeckles (By similarity). The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs (By similarity). The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 (By similarity). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends (By similarity). In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex (By similarity). NONO is involved in transcriptional regulation (By similarity). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:15860628). Important for the functional organization of GABAergic synapses (By similarity). Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (By similarity). Plays a key role during neuronal differentiation by recruiting TET1 to genomic loci and thereby regulating 5-hydroxymethylcytosine levels (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FVM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVN6-1", "uniprot_id": [ { "id": "GIMA6_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVN6", "type": "external" } ], "mass": 33691.0, "length": 304, "protein_name": "GTPase IMAP family member 6", "gene_name": "Gimap6", "organism": "Rat", "refseq_name": "GTPase IMAP family member 6", "refseq_ac": [ { "id": "NP_001011968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011968", "type": "external" } ], "gene_names_uniprotkb": "Gimap6; Ian6", "gene_names_refseq": "Gimap6; Ian6", "protein_names_uniprotkb": "GTPase IMAP family member 6; IAN-6; Immunity-associated nucleotide 6 protein", "protein_names_refseq": "GTPase IMAP family member 6; IAN-6; immune associated nucleotide 6; immunity-associated nucleotide 6 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:297076)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16103028", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006955 immune response;GO:0001822 kidney development;GO:0006914 autophagy;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5H8A2-1", "uniprot_id": [ { "id": "NMS_RAT", "url": "https://www.uniprot.org/uniprot/Q5H8A2", "type": "external" } ], "mass": 17572.0, "length": 152, "protein_name": "Neuromedin-S", "gene_name": "Nms", "organism": "Rat", "refseq_name": "neuromedin-S precursor", "refseq_ac": [ { "id": "NP_001012233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012233", "type": "external" } ], "gene_names_uniprotkb": "Nms", "gene_names_refseq": "Nms", "protein_names_uniprotkb": "Neuromedin-S", "protein_names_refseq": "neuromedin S precursor-related peptide/neuromedin S preproprotein; neuromedin-S precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:497196); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15635449;15976061;17110433;17611645;17870195;17900576;18675786;26826380", "class_list": "", "function": "Expression in hypothalamus. Potential role of NMS in regulation of gonadotropic axis. May contribute to integration of circadian rhythms, energy balance, and reproduction., [RefSeq, PubMed]; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. Stimulates the contraction of rectum and elevation of blood pressure., [UniProtKB, PubMed]; May be a potent anorexigenic hormone in the hypothalamus, and the expression of proopiomelanocortin mRNA in the Arc and corticotropin mRNA in the paraventricular hypothalamic nucleus be be involved with appetite., [RefSeq, PubMed]; NMS is implicated in the regulation of circadian rhythm and feeding behavior, [RefSeq, PubMed]; Neuromedin S stimulates the HPA axis through the CRHR(1) pathway and evokes stereotyped behavior and anxiety through mesolimbic dopamine and corticotrophin releasing hormone release., [RefSeq, PubMed]; Neuromedins U and S may play different roles in the functional regulation of neuroendocrine axes., [RefSeq, PubMed]; These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU., [RefSeq, PubMed]; These results suggest that, in the rat, endogenous NMS plays an important role in the oxytocin release response to the suckling stimulus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5H8A2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0D1-1", "uniprot_id": [ { "id": "GLOD4_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0D1", "type": "external" } ], "mass": 33268.0, "length": 298, "protein_name": "Glyoxalase domain-containing protein 4", "gene_name": "Glod4", "organism": "Rat", "refseq_name": "glyoxalase domain-containing protein 4", "refseq_ac": [ { "id": "NP_001014249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014249", "type": "external" } ], "gene_names_uniprotkb": "Glod4", "gene_names_refseq": "Glod4; RGD1307010", "protein_names_uniprotkb": "Glyoxalase domain-containing protein 4", "protein_names_refseq": "glyoxalase domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:363644)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0D1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0D7-1", "uniprot_id": [ { "id": "PEPD_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0D7", "type": "external" } ], "mass": 54751.0, "length": 492, "protein_name": "Xaa-Pro dipeptidase", "gene_name": "Pepd", "organism": "Rat", "refseq_name": "xaa-Pro dipeptidase", "refseq_ac": [ { "id": "NP_001009641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009641", "type": "external" } ], "gene_names_uniprotkb": "Pepd; AABR07002969.1", "gene_names_refseq": "Pepd", "protein_names_uniprotkb": "Xaa-Pro dipeptidase; 3.4.13.9; Imidodipeptidase; Peptidase D; Prolidase; Proline dipeptidase; X-Pro dipeptidase", "protein_names_refseq": "X-Pro dipeptidase; imidodipeptidase; prolidase; proline dipeptidase; xaa-Pro dipeptidase-like; xaa-Pro dipeptidase", "tax_id": 10116, "disease": "prolidase deficiency (Disease Ontology:DOID:0111540); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:292808)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19782660;29393594", "class_list": "", "function": "Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position. The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved. Plays an important role in collagen metabolism because the high level of iminoacids in collagen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In summary, these data suggest that maintenance of levels of proline, other amino acids and peptides containing proline in the rat brain is regulated by prolidase isoenzymes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.9", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity;GO:0102009 proline dipeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5I0D7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0I8-1", "uniprot_id": [ { "id": "NOC4L_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0I8", "type": "external" } ], "mass": 58862.0, "length": 516, "protein_name": "Nucleolar complex protein 4 homolog", "gene_name": "Noc4l", "organism": "Rat", "refseq_name": "nucleolar complex protein 4 homolog", "refseq_ac": [ { "id": "NP_001014151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014151", "type": "external" } ], "gene_names_uniprotkb": "Noc4l", "gene_names_refseq": "Noc4l; RGD1310661", "protein_names_uniprotkb": "Nucleolar complex protein 4 homolog; NOC4 protein homolog; NOC4-like protein; Nucleolar complex-associated protein 4-like protein", "protein_names_refseq": "NOC4 protein homolog; NOC4-like protein; nucleolar complex protein 4 homolog; nucleolar complex-associated protein 4-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360828); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0031965 nuclear membrane;GO:0030692 Noc4p-Nop14p complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0I8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J2D6-1", "uniprot_id": [ { "id": "GGNB1_RAT", "url": "https://www.uniprot.org/uniprot/Q5J2D6", "type": "external" } ], "mass": 40854.0, "length": 373, "protein_name": "Gametogenetin-binding protein 1", "gene_name": "Ggnbp1", "organism": "Rat", "refseq_name": "gametogenetin-binding protein 1", "refseq_ac": [ { "id": "NP_001009972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009972", "type": "external" } ], "gene_names_uniprotkb": "Ggnbp1", "gene_names_refseq": "Ggnbp1", "protein_names_uniprotkb": "Gametogenetin-binding protein 1", "protein_names_refseq": "gametogenetin-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:494520)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15625700", "class_list": "", "function": "Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5J2D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M836-1", "uniprot_id": [ { "id": "LYSM3_RAT", "url": "https://www.uniprot.org/uniprot/Q5M836", "type": "external" } ], "mass": 33702.0, "length": 300, "protein_name": "LysM and putative peptidoglycan-binding domain-containing protein 3", "gene_name": "Lysmd3", "organism": "Rat", "refseq_name": "lysM and putative peptidoglycan-binding domain-containing protein 3", "refseq_ac": [ { "id": "NP_001009698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009698", "type": "external" } ], "gene_names_uniprotkb": "Lysmd3", "gene_names_refseq": "Lysmd3; RGD1308805", "protein_names_uniprotkb": "LysM and putative peptidoglycan-binding domain-containing protein 3", "protein_names_refseq": "LysM, putative peptidoglycan-binding, domain containing 3; lysM and putative peptidoglycan-binding domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:315923)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for Golgi structural integrity., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M836-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M870-1", "uniprot_id": [ { "id": "NEUL3_RAT", "url": "https://www.uniprot.org/uniprot/Q5M870", "type": "external" } ], "mass": 28014.0, "length": 254, "protein_name": "E3 ubiquitin-protein ligase NEURL3", "gene_name": "Neurl3", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase NEURL3", "refseq_ac": [ { "id": "NP_001014122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014122", "type": "external" } ], "gene_names_uniprotkb": "Neurl3; Lincr", "gene_names_refseq": "Lincr; Neurl3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NEURL3; 2.3.2.27; Lung-inducible neuralized-related C3CH4 RING domain protein; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL3", "protein_names_refseq": "E3 ubiquitin-protein ligase LINCR; E3 ubiquitin-protein ligase NEURL3; RING-type E3 ubiquitin transferase NEURL3; lung-inducible neuralized-related C3CH4 RING domain protein; lung-inducible neuralized-related C3HC4 RING domain protein; neuralized homolog 3; neuralized-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:316326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity. Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7. Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2. Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0045087 innate immune response;GO:0016567 protein ubiquitination;GO:1901800 positive regulation of proteasomal protein catabolic process;GO:0070086 ubiquitin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M870-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M969-1", "uniprot_id": [ { "id": "NANP_RAT", "url": "https://www.uniprot.org/uniprot/Q5M969", "type": "external" } ], "mass": 27741.0, "length": 248, "protein_name": "N-acylneuraminate-9-phosphatase", "gene_name": "Nanp", "organism": "Rat", "refseq_name": "N-acylneuraminate-9-phosphatase", "refseq_ac": [ { "id": "NP_001009409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009409", "type": "external" } ], "gene_names_uniprotkb": "Nanp; Hdhd4", "gene_names_refseq": "Hdhd4; Nanp; RGD1306009", "protein_names_uniprotkb": "N-acylneuraminate-9-phosphatase; 3.1.3.29; Haloacid dehalogenase-like hydrolase domain-containing protein 4; N-acetylneuraminate-9-phosphate phosphatase; Neu5Ac-9-Pase", "protein_names_refseq": "N-acetylneuraminate-9-phosphate phosphatase; N-acylneuraminate-9-phosphatase; haloacid dehalogenase-like hydrolase domain containing 4; neu5Ac-9-Pase", "tax_id": 10116, "disease": "", "pathway": " (rno:311530); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16237198", "class_list": "", "function": "Catalyzes the dephosphorylation of N-acylneuraminate 9-phosphate (Neu5Ac-9-P) to N-acetylneuraminic acid (Neu5Ac or sialic acid) (PubMed:16237198). Can also use N-glycoloylneuraminate 9-phosphate as substrate (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.29", "type": "external" } ], "go_molecular_function": "GO:0050124 N-acylneuraminate-9-phosphatase activity;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006045 N-acetylglucosamine biosynthetic process;GO:0006054 N-acetylneuraminate metabolic process;GO:0006055 CMP-N-acetylneuraminate biosynthetic process;GO:0046380 N-acetylneuraminate biosynthetic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M969-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9H1-1", "uniprot_id": [ { "id": "LRC41_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9H1", "type": "external" } ], "mass": 88508.0, "length": 808, "protein_name": "Leucine-rich repeat-containing protein 41", "gene_name": "Lrrc41", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 41", "refseq_ac": [ { "id": "NP_001009710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009710", "type": "external" } ], "gene_names_uniprotkb": "Lrrc41", "gene_names_refseq": "Lrrc41; RGD1311221", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 41", "protein_names_refseq": "MUF1 protein; leucine-rich repeat-containing protein 41", "tax_id": 10116, "disease": "", "pathway": " (rno:362566); (R-RNO-8951664); (R-RNO-9706019); (R-RNO-983168)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9H1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPG6-1", "uniprot_id": [ { "id": "NP1L5_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPG6", "type": "external" } ], "mass": 16858.0, "length": 155, "protein_name": "Nucleosome assembly protein 1-like 5", "gene_name": "Nap1l5", "organism": "Rat", "refseq_name": "nucleosome assembly protein 1-like 5", "refseq_ac": [ { "id": "NP_001037758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037758", "type": "external" } ], "gene_names_uniprotkb": "Nap1l5", "gene_names_refseq": "Nap1l5", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 5; Histone chaperone NAP1L5", "protein_names_refseq": "histone chaperone NAP1L5; nucleosome assembly protein 1-like 5", "tax_id": 10116, "disease": "", "pathway": " (rno:688843)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19103603", "class_list": "", "function": "Expression of Nap1l5 increases over 18-fold at night in the rat pineal gland, under control of an adrenergic/cyclic AMP mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPI3-1", "uniprot_id": [ { "id": "GSKIP_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPI3", "type": "external" } ], "mass": 15557.0, "length": 139, "protein_name": "GSK3B-interacting protein", "gene_name": "Gskip", "organism": "Rat", "refseq_name": "GSK3B-interacting protein", "refseq_ac": [ { "id": "NP_001014220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014220", "type": "external" } ], "gene_names_uniprotkb": "Gskip", "gene_names_refseq": "Gskip; RGD1308470", "protein_names_uniprotkb": "GSK3B-interacting protein; GSKIP", "protein_names_refseq": "GSK3-beta interaction protein; GSK3B-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362778)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20007971", "class_list": "", "function": "A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0051018 protein kinase A binding;GO:0019207 kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006469 negative regulation of protein kinase activity;GO:0030111 regulation of Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPL1-1", "uniprot_id": [ { "id": "KRCC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPL1", "type": "external" } ], "mass": 30703.0, "length": 256, "protein_name": "Lysine-rich coiled-coil protein 1", "gene_name": "Krcc1", "organism": "Rat", "refseq_name": "lysine-rich coiled-coil protein 1", "refseq_ac": [ { "id": "NP_001009413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009413", "type": "external" } ], "gene_names_uniprotkb": "Krcc1", "gene_names_refseq": "Krcc1; RGD1306495", "protein_names_uniprotkb": "Lysine-rich coiled-coil protein 1", "protein_names_refseq": "lysine-rich coiled-coil protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312437)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Regulates CHEK1-mediated cell cycle checkpoint. Facilitates efficient recombination and homologous recombination repair. Required for proper S-phase progression and mitotic entry., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN0-1", "uniprot_id": [ { "id": "NCALD_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN0", "type": "external" } ], "mass": 22245.0, "length": 193, "protein_name": "Neurocalcin-delta", "gene_name": "Ncald", "organism": "Rat", "refseq_name": "neurocalcin-delta", "refseq_ac": [ { "id": "NP_001019542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019542", "type": "external" } ], "gene_names_uniprotkb": "Ncald", "gene_names_refseq": "Ncald", "protein_names_uniprotkb": "Neurocalcin-delta", "protein_names_refseq": "neurocalcin-delta", "tax_id": 10116, "disease": "", "pathway": " (rno:553106); (R-RNO-451308)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18178149", "class_list": "", "function": "May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0030276 clathrin binding;GO:0015631 tubulin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0009966 regulation of signal transduction;GO:0003073 regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN1-1", "uniprot_id": [ { "id": "HERC4_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN1", "type": "external" } ], "mass": 118540.0, "length": 1057, "protein_name": "Probable E3 ubiquitin-protein ligase HERC4", "gene_name": "Herc4", "organism": "Rat", "refseq_name": "probable E3 ubiquitin-protein ligase HERC4", "refseq_ac": [ { "id": "NP_001012074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012074", "type": "external" } ], "gene_names_uniprotkb": "Herc4", "gene_names_refseq": "Herc4", "protein_names_uniprotkb": "Probable E3 ubiquitin-protein ligase HERC4; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4", "protein_names_refseq": "HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4; hect domain and RLD 4; probable E3 ubiquitin-protein ligase HERC4", "tax_id": 10116, "disease": "", "pathway": " (rno:309758); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQN1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQP0-1", "uniprot_id": [ { "id": "IER5L_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQP0", "type": "external" } ], "mass": 42873.0, "length": 409, "protein_name": "Immediate early response gene 5-like protein", "gene_name": "Ier5l", "organism": "Rat", "refseq_name": "immediate early response gene 5-like protein", "refseq_ac": [ { "id": "NP_001020212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020212", "type": "external" } ], "gene_names_uniprotkb": "Ier5l", "gene_names_refseq": "Ier5l", "protein_names_uniprotkb": "Immediate early response gene 5-like protein", "protein_names_refseq": "immediate early response gene 5-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:499772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQP0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQR5-1", "uniprot_id": [ { "id": "IMP4_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQR5", "type": "external" } ], "mass": 33656.0, "length": 291, "protein_name": "U3 small nucleolar ribonucleoprotein protein IMP4", "gene_name": "Imp4", "organism": "Rat", "refseq_name": "U3 small nucleolar ribonucleoprotein IMP4", "refseq_ac": [ { "id": "NP_001009700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009700", "type": "external" } ], "gene_names_uniprotkb": "Imp4", "gene_names_refseq": "Imp4; LRRGT00017; RGD1308463", "protein_names_uniprotkb": "U3 small nucleolar ribonucleoprotein protein IMP4; U3 snoRNP protein IMP4", "protein_names_refseq": "IMP4 homolog, U3 small nucleolar ribonucleoprotein; IMP4, U3 small nucleolar ribonucleoprotein, homolog; U3 small nucleolar ribonucleoprotein IMP4; U3 small nucleolar ribonucleoprotein protein IMP4; U3 snoRNP protein 4 homolog; U3 snoRNP protein IMP4", "tax_id": 10116, "disease": "", "pathway": " (rno:316317); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0042134 rRNA primary transcript binding", "go_cellular_component": "GO:0030684 preribosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0034457 Mpp10 complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RK28-1", "uniprot_id": [ { "id": "CX4L3_RAT", "url": "https://www.uniprot.org/uniprot/Q5RK28", "type": "external" } ], "mass": 9598.0, "length": 83, "protein_name": "Cytochrome c oxidase associated subunit FA4L3", "gene_name": "Coxfa4l3", "organism": "Rat", "refseq_name": "cytochrome c oxidase associated subunit FA4L3", "refseq_ac": [ { "id": "NP_001008518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008518", "type": "external" } ], "gene_names_uniprotkb": "Coxfa4l3; Nmes1", "gene_names_refseq": "C3h15orf48; Coxfa4l3; Nmes1", "protein_names_uniprotkb": "Cytochrome c oxidase associated subunit FA4L3; Normal mucosa of esophagus-specific gene 1 protein", "protein_names_refseq": "cytochrome c oxidase associated subunit FA4L3; normal mucosa of esophagus-specific gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:302884)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling. Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RK28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U204-1", "uniprot_id": [ { "id": "LTOR3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U204", "type": "external" } ], "mass": 13580.0, "length": 124, "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "Lamtor3", "organism": "Rat", "refseq_name": "ragulator complex protein LAMTOR3", "refseq_ac": [ { "id": "NP_001008376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008376", "type": "external" } ], "gene_names_uniprotkb": "Lamtor3; Map2k1ip1", "gene_names_refseq": "Lamtor3; MP1; Map2k1ip1; Mapksp1", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; Mitogen-activated protein kinase kinase 1-interacting protein 1", "protein_names_refseq": "MEK partner 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1-interacting protein 1; mitogen-activated protein kinase scaffold protein 1; ragulator complex protein LAMTOR3", "tax_id": 10116, "disease": "", "pathway": " (rno:362045); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-380972); (R-RNO-5628897); (R-RNO-5674135); (R-RNO-6798695); (R-RNO-8943724); (R-RNO-9639288)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "15923628", "class_list": "", "function": "As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The MP1/p14 complex regulates PAK1-dependent ERK activation during adhesion and cell spreading but is not required for ERK activation by platelet-derived growth factor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005770 late endosome;GO:0071986 Ragulator complex;GO:1990877 FNIP-folliculin RagC/D GAP", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043410 positive regulation of MAPK cascade;GO:0032008 positive regulation of TOR signaling;GO:0008104 intracellular protein localization;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2P2-1", "uniprot_id": [ { "id": "IGS11_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2P2", "type": "external" } ], "mass": 46021.0, "length": 428, "protein_name": "Immunoglobulin superfamily member 11", "gene_name": "Igsf11", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 11 precursor", "refseq_ac": [ { "id": "NP_001013138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013138", "type": "external" } ], "gene_names_uniprotkb": "Igsf11", "gene_names_refseq": "Igsf11", "protein_names_uniprotkb": "Immunoglobulin superfamily member 11; IgSF11", "protein_names_refseq": "immunoglobulin superfamily member 11 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:303926)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity)., [UniProtKB]; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005911 cell-cell junction;GO:0014069 postsynaptic density;GO:0060076 excitatory synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1900273 positive regulation of long-term synaptic potentiation;GO:0048167 regulation of synaptic plasticity;GO:0061885 positive regulation of mini excitatory postsynaptic potential;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045185 maintenance of protein location", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2P2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Q4-1", "uniprot_id": [ { "id": "PAR16_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Q4", "type": "external" } ], "mass": 36712.0, "length": 322, "protein_name": "Protein mono-ADP-ribosyltransferase PARP16", "gene_name": "Parp16", "organism": "Rat", "refseq_name": "protein mono-ADP-ribosyltransferase PARP16", "refseq_ac": [ { "id": "NP_001014115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014115", "type": "external" } ], "gene_names_uniprotkb": "Parp16; Artd15", "gene_names_refseq": "ARTD15; LRRGT00109; Parp16; RGD1306243", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase PARP16; 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; Poly [ADP-ribose] polymerase 16", "protein_names_refseq": "ADP-ribosyltransferase diphtheria toxin-like 15; PARP-16; mono [ADP-ribose] polymerase PARP16; poly [ADP-ribose] polymerase 16; protein mono-ADP-ribosyltransferase PARP16", "tax_id": 10116, "disease": "", "pathway": " (rno:315760)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33144524", "class_list": "", "function": "Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0036498 IRE1-mediated unfolded protein response;GO:1990830 cellular response to leukemia inhibitory factor;GO:0030968 endoplasmic reticulum unfolded protein response;GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHZ6-1", "uniprot_id": [ { "id": "KLHL7_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHZ6", "type": "external" } ], "mass": 65970.0, "length": 586, "protein_name": "Kelch-like protein 7", "gene_name": "Klhl7", "organism": "Rat", "refseq_name": "kelch-like protein 7", "refseq_ac": [ { "id": "NP_001012187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012187", "type": "external" } ], "gene_names_uniprotkb": "Klhl7", "gene_names_refseq": "Klhl7", "protein_names_uniprotkb": "Kelch-like protein 7", "protein_names_refseq": "kelch-like 7; kelch-like protein 7", "tax_id": 10116, "disease": "cold-induced sweating syndrome 3 (Disease Ontology:DOID:0080331); retinitis pigmentosa 42 (Disease Ontology:DOID:0110386)", "pathway": " (rno:362303)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XHZ6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI02-1", "uniprot_id": [ { "id": "PDILT_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI02", "type": "external" } ], "mass": 68267.0, "length": 590, "protein_name": "Protein disulfide-isomerase-like protein of the testis", "gene_name": "Pdilt", "organism": "Rat", "refseq_name": "protein disulfide-isomerase-like protein of the testis precursor", "refseq_ac": [ { "id": "NP_001013924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013924", "type": "external" } ], "gene_names_uniprotkb": "Pdilt", "gene_names_refseq": "Pdilt; RGD1307822", "protein_names_uniprotkb": "Protein disulfide-isomerase-like protein of the testis", "protein_names_refseq": "protein disulfide-isomerase-like protein of the testis precursor; protein disulfide-isomerase-like protein of the testis", "tax_id": 10116, "disease": "", "pathway": " (rno:293544)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17507649;29393594", "class_list": "", "function": "Probable redox-inactive chaperone involved in spermatogenesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0016477 cell migration;GO:0007286 spermatid development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XI02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI20-1", "uniprot_id": [ { "id": "MTURN_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI20", "type": "external" } ], "mass": 14832.0, "length": 131, "protein_name": "Maturin", "gene_name": "Mturn", "organism": "Rat", "refseq_name": "maturin", "refseq_ac": [ { "id": "NP_001007646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007646", "type": "external" } ], "gene_names_uniprotkb": "Mturn", "gene_names_refseq": "Mturn", "protein_names_uniprotkb": "Maturin; Maturin neural progenitor differentiation regulator protein homolog", "protein_names_refseq": "UPF0452 protein C7orf41 homolog; maturin neural progenitor differentiation regulator protein homolog; maturin", "tax_id": 10116, "disease": "", "pathway": " (rno:297109)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (By similarity). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045654 positive regulation of megakaryocyte differentiation;GO:0023051 regulation of signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI31-1", "uniprot_id": [ { "id": "PIGS_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI31", "type": "external" } ], "mass": 61724.0, "length": 555, "protein_name": "GPI-anchor transamidase component PIGS", "gene_name": "Pigs", "organism": "Rat", "refseq_name": "GPI-anchor transamidase component PIGS", "refseq_ac": [ { "id": "NP_001006602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006602", "type": "external" } ], "gene_names_uniprotkb": "Pigs", "gene_names_refseq": "Pigs", "protein_names_uniprotkb": "GPI-anchor transamidase component PIGS; Phosphatidylinositol-glycan biosynthesis class S protein", "protein_names_refseq": "GPI transamidase component PIG-S; GPI-anchor transamidase component PIGS; phosphatidylinositol glycan, class S; phosphatidylinositol-glycan biosynthesis class S protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 95 (Disease Ontology:DOID:0070382)", "pathway": " (rno:303277); (R-RNO-162791)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI31-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI51-1", "uniprot_id": [ { "id": "KIF2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI51", "type": "external" } ], "mass": 75004.0, "length": 664, "protein_name": "Kinesin-like protein KIF2B", "gene_name": "Kif2b", "organism": "Rat", "refseq_name": "kinesin-like protein KIF2B", "refseq_ac": [ { "id": "NP_001005874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005874", "type": "external" } ], "gene_names_uniprotkb": "Kif2b", "gene_names_refseq": "Kif2b", "protein_names_uniprotkb": "Kinesin-like protein KIF2B", "protein_names_refseq": "kinesin-like protein KIF2B", "tax_id": 10116, "disease": "", "pathway": " (rno:287624); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-6811434); (R-RNO-68877); (R-RNO-9648025); (R-RNO-983189)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "29393594;38843836", "class_list": "", "function": "Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromosome congression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0051983 regulation of chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XI51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIA9-1", "uniprot_id": [ { "id": "KLD8B_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIA9", "type": "external" } ], "mass": 37593.0, "length": 354, "protein_name": "Kelch domain-containing protein 8B", "gene_name": "Klhdc8b", "organism": "Rat", "refseq_name": "kelch domain-containing protein 8B", "refseq_ac": [ { "id": "NP_001007686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007686", "type": "external" } ], "gene_names_uniprotkb": "Klhdc8b", "gene_names_refseq": "Klhdc8b", "protein_names_uniprotkb": "Kelch domain-containing protein 8B", "protein_names_refseq": "kelch domain-containing protein 8B", "tax_id": 10116, "disease": "Hodgkin's lymphoma (Disease Ontology:DOID:8567)", "pathway": " (rno:306589)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045171 intercellular bridge;GO:0030496 midbody;GO:0110070 cellularization cleavage furrow", "go_biological_process": "GO:1902410 mitotic cytokinetic process;GO:0140014 mitotic nuclear division;GO:0098813 nuclear chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIA9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC1-1", "uniprot_id": [ { "id": "GMPPA_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC1", "type": "external" } ], "mass": 46191.0, "length": 420, "protein_name": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "gene_name": "Gmppa", "organism": "Rat", "refseq_name": "mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "refseq_ac": [ { "id": "NP_001020227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020227", "type": "external" } ], "gene_names_uniprotkb": "Gmppa", "gene_names_refseq": "Gmppa", "protein_names_uniprotkb": "Mannose-1-phosphate guanylyltransferase regulatory subunit alpha; GDP-mannose pyrophosphorylase A; GTP-mannose-1-phosphate guanylyltransferase alpha", "protein_names_refseq": "GTP-mannose-1-phosphate guanylyltransferase alpha; mannose-1-phosphate guanyltransferase alpha; mannose-1-phosphate guanylyltransferase regulatory subunit alpha", "tax_id": 10116, "disease": "alacrima, achalasia, and impaired intellectual development syndrome (Disease Ontology:DOID:0112321)", "pathway": " (rno:501167); (R-RNO-446205)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0016740 transferase activity;GO:0140299 molecular sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0120508 GDP-mannose pyrophosphorylase complex", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0019673 GDP-mannose metabolic process;GO:0050890 cognition;GO:0050905 neuromuscular process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIC1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE6-1", "uniprot_id": [ { "id": "HIBCH_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE6", "type": "external" } ], "mass": 43025.0, "length": 385, "protein_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial", "gene_name": "Hibch", "organism": "Rat", "refseq_name": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001013130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013130", "type": "external" } ], "gene_names_uniprotkb": "Hibch", "gene_names_refseq": "Hibch", "protein_names_uniprotkb": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-coenzyme A hydrolase; 3.1.2.4; HIB-CoA hydrolase; HIBYL-CoA-H", "protein_names_refseq": "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform 2; 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-Coenzyme A hydrolase; HIB-CoA hydrolase; HIBYL-CoA-H", "tax_id": 10116, "disease": "3-hydroxyisobutryl-CoA hydrolase deficiency (Disease Ontology:DOID:0060949); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:301384); (R-RNO-70895)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "29393594;8188708;8824301", "class_list": "", "function": "Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.4", "type": "external" } ], "go_molecular_function": "GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006574 L-valine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIE6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIG5-1", "uniprot_id": [ { "id": "GKAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIG5", "type": "external" } ], "mass": 41932.0, "length": 366, "protein_name": "G kinase-anchoring protein 1", "gene_name": "Gkap1", "organism": "Rat", "refseq_name": "G kinase-anchoring protein 1", "refseq_ac": [ { "id": "NP_001012160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012160", "type": "external" } ], "gene_names_uniprotkb": "Gkap1", "gene_names_refseq": "Gkap1", "protein_names_uniprotkb": "G kinase-anchoring protein 1", "protein_names_refseq": "G kinase-anchoring protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361202)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007165 signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH9-1", "uniprot_id": [ { "id": "HPDL_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH9", "type": "external" } ], "mass": 40032.0, "length": 371, "protein_name": "4-hydroxyphenylpyruvate dioxygenase-like protein", "gene_name": "Hpdl", "organism": "Rat", "refseq_name": "4-hydroxyphenylpyruvate dioxygenase-like protein", "refseq_ac": [ { "id": "NP_001014090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014090", "type": "external" } ], "gene_names_uniprotkb": "Hpdl; Gloxd1", "gene_names_refseq": "Gloxd1; Hpdl; RGD1310014", "protein_names_uniprotkb": "4-hydroxyphenylpyruvate dioxygenase-like protein; 1.13.11.46; Glyoxalase domain-containing protein 1; HPDL", "protein_names_refseq": "4-hydroxyphenylpyruvate dioxygenase-like protein; glyoxalase domain containing 1; glyoxalase domain-containing protein 1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 83 (Disease Ontology:DOID:0112346); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:313521); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.46", "type": "external" } ], "go_molecular_function": "GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity;GO:0046872 metal ion binding;GO:0050585 4-hydroxymandelate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009072 aromatic amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIH9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIJ1-1", "uniprot_id": [ { "id": "HMCES_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIJ1", "type": "external" } ], "mass": 40222.0, "length": 353, "protein_name": "Abasic site processing protein HMCES", "gene_name": "Hmces", "organism": "Rat", "refseq_name": "abasic site processing protein HMCES", "refseq_ac": [ { "id": "NP_001020218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020218", "type": "external" } ], "gene_names_uniprotkb": "Hmces; Srapd1", "gene_names_refseq": "Hmces", "protein_names_uniprotkb": "Abasic site processing protein HMCES; 3.4.-.-; 4.-.-.-; ES cell-specific 5hmC-binding protein; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Peptidase HMCES; SRAP domain-containing protein 1", "protein_names_refseq": "5-hydroxymethylcytosine (hmC) binding, ES cell-specific; ES cell-specific 5hmC-binding protein; SRAP domain-containing protein 1; UPF0361 protein C3orf37 homolog; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; peptidase HMCES; putative endonuclease HMCES; putative peptidase SRAPD1", "tax_id": 10116, "disease": "", "pathway": " (rno:500251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. The HMCES DNA-protein cross-link is then either reversed or degraded. HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites. The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (By similarity). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway. Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0003697 single-stranded DNA binding;GO:0140431 DNA-(abasic site) binding;GO:0160129 protein-DNA covalent cross-linking activity", "go_cellular_component": "GO:0005657 replication fork", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62725-1", "uniprot_id": [ { "id": "NFYC_RAT", "url": "https://www.uniprot.org/uniprot/Q62725", "type": "external" } ], "mass": 37254.0, "length": 335, "protein_name": "Nuclear transcription factor Y subunit gamma", "gene_name": "Nfyc", "organism": "Rat", "refseq_name": "nuclear transcription factor Y subunit gamma isoform 1", "refseq_ac": [ { "id": "NP_036998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036998", "type": "external" } ], "gene_names_uniprotkb": "Nfyc", "gene_names_refseq": "CBF-C; Nfyc", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; CBF-C; CCAAT-binding transcription factor subunit C; NF-YC; Nuclear transcription factor Y subunit C", "protein_names_refseq": "CAAT box DNA-binding protein subunit C; CCAAT binding factor of CBF-C/NFY-C; CCAAT-binding transcription factor subunit C; NF-YC; nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma isoform 1; nuclear transcription factor-Y gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:25337)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12167641;21164521;24014123;7878029", "class_list": "", "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB]; NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor, [RefSeq, PubMed]; NF-Y cooperates with FOXO3a to recruit CBP/p300 to the bim promoter to form a stable multi-protein/DNA complex that activates bim transcription after survival factor withdrawal., [RefSeq, PubMed]; Upregulation of NF-YC might play an important role in the pathophysiology via proapoptotic protein Bim after middle cerebral artery occlusion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q566C6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62725-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62803-1", "uniprot_id": [ { "id": "HYALP_RAT", "url": "https://www.uniprot.org/uniprot/Q62803", "type": "external" } ], "mass": 58412.0, "length": 512, "protein_name": "Hyaluronidase PH-20", "gene_name": "Spam1", "organism": "Rat", "refseq_name": "hyaluronidase PH-20 precursor", "refseq_ac": [ { "id": "NP_446419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446419", "type": "external" } ], "gene_names_uniprotkb": "Spam1; Ph20; Spam", "gene_names_refseq": "Spam1; Spam", "protein_names_uniprotkb": "Hyaluronidase PH-20; 3.2.1.35; Hyal-PH20; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface antigen 2B1; Sperm surface protein PH-20", "protein_names_refseq": "hyal-PH20; hyaluronidase PH-20 precursor; hyaluronidase PH-20; hyaluronoglucosaminidase PH-20; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); sperm surface antigen 2B1; sperm surface protein PH-20", "tax_id": 10116, "disease": "", "pathway": " (rno:117037)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15062858;8914077", "class_list": "glycogene;glycosylhydrolase", "function": "Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (By similarity)., [UniProtKB]; Results describe the factors regulating the expression of epididymal sperm adhesion molecule SPAM1/2B1., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007155 cell adhesion;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0007338 single fertilization;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62803-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62809-1", "uniprot_id": [ { "id": "NOGG_RAT", "url": "https://www.uniprot.org/uniprot/Q62809", "type": "external" } ], "mass": 16139.0, "length": 144, "protein_name": "Noggin", "gene_name": "Nog", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nog", "gene_names_refseq": "", "protein_names_uniprotkb": "Noggin", "protein_names_refseq": "", "tax_id": 10116, "disease": "proximal symphalangism (Disease Ontology:DOID:0050788); tarsal-carpal coalition syndrome (Disease Ontology:DOID:0050789); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); proximal symphalangism 1 (Disease Ontology:DOID:0080787); multiple synostoses syndrome 1 (Disease Ontology:DOID:0081317); brachydactyly type B2 (Disease Ontology:DOID:0110975); acute kidney tubular necrosis (Disease Ontology:DOID:12556); Huntington's disease (Disease Ontology:DOID:12858); cancer (Disease Ontology:DOID:162); craniosynostosis (Disease Ontology:DOID:2340); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hyperopia (Disease Ontology:DOID:9834)", "pathway": " (rno:25495)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7666191", "class_list": "", "function": "Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (By similarity). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0098793 presynapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0048570 notochord morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62809-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63247-1", "uniprot_id": [ { "id": "FOXJ1_RAT", "url": "https://www.uniprot.org/uniprot/Q63247", "type": "external" } ], "mass": 45566.0, "length": 421, "protein_name": "Forkhead box protein J1", "gene_name": "Foxj1", "organism": "Rat", "refseq_name": "forkhead box protein J1", "refseq_ac": [ { "id": "NP_446284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446284", "type": "external" } ], "gene_names_uniprotkb": "Foxj1; AABR07030823.1; Hfh4", "gene_names_refseq": "Foxj1; Hfh-4; Hfh4", "protein_names_uniprotkb": "Forkhead box protein J1; HFH-4; Hepatocyte nuclear factor 3 forkhead homolog 4", "protein_names_refseq": "forkhead box protein J1; hepatocyte nuclear factor 3 forkhead homolog 4", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 43 (Disease Ontology:DOID:0111856); congenital heart disease (Disease Ontology:DOID:1682); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:116557)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27660208;7753791", "class_list": "", "function": "Expression and localization of FOXJ1 in S100beta-positive multiciliated cells of the rat pituitary has been described., [RefSeq, PubMed]; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0060429 epithelium development;GO:0002508 central tolerance induction;GO:0002635 negative regulation of germinal center formation;GO:0002897 positive regulation of central B cell tolerance induction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63247-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63250-1", "uniprot_id": [ { "id": "FOXE3_RAT", "url": "https://www.uniprot.org/uniprot/Q63250", "type": "external" } ], "mass": 30469.0, "length": 286, "protein_name": "Forkhead box protein E3", "gene_name": "Foxe3", "organism": "Rat", "refseq_name": "forkhead box protein E3", "refseq_ac": [ { "id": "NP_599166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599166", "type": "external" } ], "gene_names_uniprotkb": "Foxe3; Fkhl12; Freac8; Hfh7", "gene_names_refseq": "FREAC-8; Foxe3; HFH7; HNF3", "protein_names_uniprotkb": "Forkhead box protein E3; FREAC-8; Forkhead-related protein FKHL12; Forkhead-related transcription factor 8; HFH-7; Hepatocyte nuclear factor 3 forkhead homolog 7", "protein_names_refseq": "forkhead box protein E3; forkhead-related protein FKHL12; forkhead-related transcription factor 8; hepatocyte nuclear factor 3 forkhead homolog 7", "tax_id": 10116, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); anterior segment dysgenesis 2 (Disease Ontology:DOID:0080607); cataract 34 multiple types (Disease Ontology:DOID:0110230); congenital aphakia (Disease Ontology:DOID:11367); thoracic aortic aneurysm (Disease Ontology:DOID:14004)", "pathway": " (rno:171302)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7683413", "class_list": "", "function": "Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (By similarity). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V6Y8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002930 trabecular meshwork development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63250-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63258-1", "uniprot_id": [ { "id": "ITA7_RAT", "url": "https://www.uniprot.org/uniprot/Q63258", "type": "external" } ], "mass": 124194.0, "length": 1135, "protein_name": "Integrin alpha-7", "gene_name": "Itga7", "organism": "Rat", "refseq_name": "integrin alpha-7 isoform 4 precursor", "refseq_ac": [ { "id": "NP_110469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110469", "type": "external" } ], "gene_names_uniprotkb": "Itga7", "gene_names_refseq": "Itga7", "protein_names_uniprotkb": "Integrin alpha-7; H36-alpha7", "protein_names_refseq": "H36-alpha7; alpha 7A integrin; integrin alpha-7 isoform 4 precursor; integrin alpha-7", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); muscular disease (Disease Ontology:DOID:0080000); congenital muscular dystrophy due to integrin alpha-7 deficiency (Disease Ontology:DOID:0110639); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); arteriosclerosis (Disease Ontology:DOID:2349)", "pathway": " (rno:81008); (R-RNO-3000157); (R-RNO-3000178)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1315319;17598176;18940796;20019333;22659335;8126096;8626012", "class_list": "", "function": "Alpha(7)beta(1) integrin is a potential receptor for COMP. The protective effects of COMP are mainly mediated through interaction with alpha(7)beta(1) integrin., [RefSeq, PubMed]; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation., [UniProtKB, PubMed, PubMed]; The laminin-binding integrin alpha7beta1 is oxidized by hydrogen peroxide at specific sites and thereby redox regulated in its binding activity., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZX9;Q63026;Q63027", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0046872 metal ion binding;GO:0043236 laminin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031594 neuromuscular junction;GO:0042383 sarcolemma;GO:0005927 muscle tendon junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0098609 cell-cell adhesion;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63258-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63317-1", "uniprot_id": [ { "id": "LY6B_RAT", "url": "https://www.uniprot.org/uniprot/Q63317", "type": "external" } ], "mass": 14130.0, "length": 135, "protein_name": "Lymphocyte antigen 6B", "gene_name": "Ly6b", "organism": "Rat", "refseq_name": "lymphocyte antigen 6B precursor", "refseq_ac": [ { "id": "NP_640350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640350", "type": "external" } ], "gene_names_uniprotkb": "Ly6b", "gene_names_refseq": "Ly6b; Ly6i", "protein_names_uniprotkb": "Lymphocyte antigen 6B; Ly-6B", "protein_names_refseq": "Ly6-B antigen; ly-6B; lymphocyte antigen 6 complex, locus B; lymphocyte antigen 6B precursor; lymphocyte antigen 6B; lymphocyte antigen 6C", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (rno:246138)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2154400", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63317-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63378-1", "uniprot_id": [ { "id": "KLRBF_RAT", "url": "https://www.uniprot.org/uniprot/Q63378", "type": "external" } ], "mass": 24543.0, "length": 217, "protein_name": "Killer cell lectin-like receptor subfamily B member 1F", "gene_name": "Klrb1f", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily B member 1F", "refseq_ac": [ { "id": "NP_001078872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078872", "type": "external" } ], "gene_names_uniprotkb": "Klrb1f; Klrb1c; Nkrp1b; Nkrp1d; Nkrp1f", "gene_names_refseq": "Klrb1c; Klrb1f; NKR-P1F", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily B member 1F; Natural killer cell surface protein NKR-P1F", "protein_names_refseq": "NKR-P1B protein; killer cell lectin like receptor B1C; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1C; killer cell lectin-like receptor subfamily B member 1F; natural killer cell surface protein NKR-P1F", "tax_id": 10116, "disease": "", "pathway": " (rno:683758)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17462921;25382546;9390275", "class_list": "", "function": "Binds CLEC2I/Clr-g leading to activation of natural killer cells or stimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells (By similarity)., [UniProtKB]; NKR-P1F and NKR-P1G receptors expressed by NK cells and T lymphocytes in liver and gut have been functionally characterized., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0042269 regulation of natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63378-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63447-1", "uniprot_id": [ { "id": "NPY4R_RAT", "url": "https://www.uniprot.org/uniprot/Q63447", "type": "external" } ], "mass": 42568.0, "length": 375, "protein_name": "Neuropeptide Y receptor type 4", "gene_name": "Npy4r", "organism": "Rat", "refseq_name": "neuropeptide Y receptor type 4", "refseq_ac": [ { "id": "NP_113769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113769", "type": "external" } ], "gene_names_uniprotkb": "Npy4r; Ppyr1", "gene_names_refseq": "Npy4r; Ppyr1", "protein_names_uniprotkb": "Neuropeptide Y receptor type 4; NPY4-R; PP1; Pancreatic polypeptide receptor 1", "protein_names_refseq": "NPY4-R; PP1; neuropeptide Y receptor type 4; pancreatic polypeptide receptor 1", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:29471); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "16155008;16950545;35453028;8643460;8643536;9210181", "class_list": "", "function": "G protein-coupled receptor for PPY/pancreatic polypeptide/PP that is negatively coupled to cAMP (PubMed:8643536). Has much lower affinity for the NPY/neuropeptide Y and PYY/peptide YY (PubMed:8643536)., [UniProtKB, PubMed]; Localization of neuropeptide receptor NPY4R in rat retina., [RefSeq, PubMed]; Results suggest that refeeding stimulates the expression of Y4R gene in the brainstem and that leptin may be one of the peripheral factors involved in this anorectic signaling mechanism [NPY4R], [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62892", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0042277 peptide binding;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63447-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63494-1", "uniprot_id": [ { "id": "KCAB3_RAT", "url": "https://www.uniprot.org/uniprot/Q63494", "type": "external" } ], "mass": 43690.0, "length": 404, "protein_name": "Voltage-gated potassium channel subunit beta-3", "gene_name": "Kcnab3", "organism": "Rat", "refseq_name": "voltage-gated potassium channel subunit beta-3", "refseq_ac": [ { "id": "NP_113840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113840", "type": "external" } ], "gene_names_uniprotkb": "Kcnab3; Ckbeta3", "gene_names_refseq": "Kcnab3", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-3; 1.1.1.-; K(+) channel subunit beta-3; Kv-beta-3; RCK beta3", "protein_names_refseq": "K(+) channel subunit beta-3; RCK beta3; kv-beta-3; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium voltage gated channel, shaker related subfamily, beta member 3; voltage-gated potassium channel subunit beta-3", "tax_id": 10116, "disease": "", "pathway": " (rno:58981); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15111404;8549760", "class_list": "", "function": "Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:8549760). The beta-3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Inactivates Kv1.4/KCNA4 alpha subunit-containing Kv channel current but not Kv1.1/KCNA1 or Kv1.5/KCNA5 channels (PubMed:8549760). May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; The auxiliary beta4-subunit has a function in rat large-conductance Ca(2+)-activated K(+) channel, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KML7", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008076 voltage-gated potassium channel complex;GO:0044224 juxtaparanode region of axon;GO:0016020 membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0045445 myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63494-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63569-1", "uniprot_id": [ { "id": "PRS6A_RAT", "url": "https://www.uniprot.org/uniprot/Q63569", "type": "external" } ], "mass": 49160.0, "length": 439, "protein_name": "26S proteasome regulatory subunit 6A", "gene_name": "Psmc3", "organism": "Rat", "refseq_name": "26S proteasome regulatory subunit 6A", "refseq_ac": [ { "id": "NP_113783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113783", "type": "external" } ], "gene_names_uniprotkb": "Psmc3; Tbp1", "gene_names_refseq": "Psmc3", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA; TBP-1; Tat-binding protein 1", "protein_names_refseq": "26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; TAT-binding protein 1; TBP-1; proteasome (prosome, macropain) 26S subunit, ATPase 3; spermatogenic cell/sperm-associated TAT-binding protein homolog SATA", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29677); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 2, "publication_id_list": "8607789;9266764", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97638", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0043921 host-mediated perturbation of viral transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63569-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63617-1", "uniprot_id": [ { "id": "HYOU1_RAT", "url": "https://www.uniprot.org/uniprot/Q63617", "type": "external" } ], "mass": 111289.0, "length": 999, "protein_name": "Hypoxia up-regulated protein 1", "gene_name": "Hyou1", "organism": "Rat", "refseq_name": "hypoxia up-regulated protein 1 precursor", "refseq_ac": [ { "id": "NP_620222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620222", "type": "external" } ], "gene_names_uniprotkb": "Hyou1; Hsph4; Orp150", "gene_names_refseq": "Cab140; Hyou1; Orp150", "protein_names_uniprotkb": "Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150", "protein_names_refseq": "150 kDa oxygen-regulated protein; ORP-150; hypoxia up-regulated protein 1 precursor; hypoxia up-regulated protein 1; oxygen regulated protein (150kD)", "tax_id": 10116, "disease": "immunodeficiency 59 (Disease Ontology:DOID:0111974)", "pathway": " (rno:192235)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12475965;21536389;23707263;24090084;28028074;29098793;29393594;38843836;8617779;9020069", "class_list": "", "function": "150-kDa oxygen-regulated protein (ORP150) levels were significantly increased in rat retinas after induction of diabetes. Vascular endothelial growth factor (VEGF) and the pro-inflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) induced upregulation of ORP150 in HRMEC., [RefSeq, PubMed]; Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum., [RefSeq, PubMed]; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LPA promotes VEGF secretion at the post-translation level by up-regulating ORP150 expression., [RefSeq, PubMed]; Results imply a probable role of ORP150 in the changes in appearance and function of pancreatic beta cells following acute necrotizing pancreatitis, through the pathway of endoplasmic reticulum stress., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum", "go_biological_process": "GO:0002931 response to ischemia;GO:0043066 negative regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q63617-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63746-1", "uniprot_id": [ { "id": "IKBA_RAT", "url": "https://www.uniprot.org/uniprot/Q63746", "type": "external" } ], "mass": 35017.0, "length": 314, "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "Nfkbia", "organism": "Rat", "refseq_name": "NF-kappa-B inhibitor alpha", "refseq_ac": [ { "id": "NP_001099190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099190", "type": "external" } ], "gene_names_uniprotkb": "Nfkbia; Ikba", "gene_names_refseq": "Nfkbia; RL/IF-1", "protein_names_uniprotkb": "NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; RL/IF-1", "protein_names_refseq": "I-kappa-B-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; NF-kappa-B inhibitor alpha; ikB-alpha; ikappaBalpha; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); childhood-onset asthma (Disease Ontology:DOID:0080815); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); ectodermal dysplasia and immunodeficiency 2 (Disease Ontology:DOID:0081079); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); nephrotic syndrome (Disease Ontology:DOID:1184); alcoholic hepatitis (Disease Ontology:DOID:12351); Sjogren's syndrome (Disease Ontology:DOID:12894); lung cancer (Disease Ontology:DOID:1324); diarrhea (Disease Ontology:DOID:13250); toxic shock syndrome (Disease Ontology:DOID:14115); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); glioblastoma (Disease Ontology:DOID:3068); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); gastritis (Disease Ontology:DOID:4029); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); collagen disease (Disease Ontology:DOID:854); Hodgkin's lymphoma (Disease Ontology:DOID:8567); multiple myeloma (Disease Ontology:DOID:9538); encephalitis (Disease Ontology:DOID:9588); pulmonary emphysema (Disease Ontology:DOID:9675); toxoplasmosis (Disease Ontology:DOID:9965)", "pathway": " (rno:25493); (R-RNO-1169091); (R-RNO-1810476); (R-RNO-202424); (R-RNO-209560); (R-RNO-2871837); (R-RNO-445989); (R-RNO-4755510); (R-RNO-5607764); (R-RNO-5689880); (R-RNO-9020702); (R-RNO-933542); (R-RNO-9860927)", "pathway_count": 13, "publication_count": 15, "publication_id_list": "11266466;11270616;11291593;11490015;12133632;12466147;14560113;1588976;1741294;22022389;26407569;31816325;32007531;32926510;37768316", "class_list": "", "function": "High IKB-alpha expression is associated with diabetic retinopathy., [RefSeq, PubMed]; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription., [UniProtKB, UniProtKB]; NEDD4L Promotes IkappaBalpha Ubiquitination and Degradation in the Pathogenesis of Diabetic Retinopathy., [RefSeq, PubMed]; Pinitol attenuates LPS-induced pneumonia in experimental animals: Possible role via inhibition of the TLR-4 and NF-kappaB/IkappaBalpha signaling cascade pathway., [RefSeq, PubMed]; The present study demonstrated that Siglec1 exerts its proinflammatory effects through increasing miR-1260, leading to decreased expression of IkappaBalpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 33, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RYS5", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0033256 I-kappaB/NF-kappaB complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0070498 interleukin-1-mediated signaling pathway;GO:0010888 negative regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q63746-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641W2-1", "uniprot_id": [ { "id": "MYG1_RAT", "url": "https://www.uniprot.org/uniprot/Q641W2", "type": "external" } ], "mass": 42889.0, "length": 381, "protein_name": "MYG1 exonuclease", "gene_name": "Myg1", "organism": "Rat", "refseq_name": "MYG1 exonuclease precursor", "refseq_ac": [ { "id": "NP_001005545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005545", "type": "external" } ], "gene_names_uniprotkb": "Myg1; C12orf10", "gene_names_refseq": "C12orf10; Myg1", "protein_names_uniprotkb": "MYG1 exonuclease; 3.1.-.-", "protein_names_refseq": "MYG1 exonuclease precursor; UPF0160 protein MYG1, mitochondrial; melanocyte proliferating gene 1", "tax_id": 10116, "disease": "vitiligo (Disease Ontology:DOID:12306)", "pathway": " (rno:300258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000959 mitochondrial RNA metabolic process;GO:0006397 mRNA processing;GO:0006364 rRNA processing;GO:0035641 locomotory exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641W2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641X6-1", "uniprot_id": [ { "id": "MORN1_RAT", "url": "https://www.uniprot.org/uniprot/Q641X6", "type": "external" } ], "mass": 53189.0, "length": 483, "protein_name": "MORN repeat-containing protein 1", "gene_name": "Morn1", "organism": "Rat", "refseq_name": "MORN repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001005544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005544", "type": "external" } ], "gene_names_uniprotkb": "Morn1", "gene_names_refseq": "Morn1", "protein_names_uniprotkb": "MORN repeat-containing protein 1", "protein_names_refseq": "MORN repeat-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:298676)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64620-1", "uniprot_id": [ { "id": "PPP6_RAT", "url": "https://www.uniprot.org/uniprot/Q64620", "type": "external" } ], "mass": 35159.0, "length": 305, "protein_name": "Serine/threonine-protein phosphatase 6 catalytic subunit", "gene_name": "Ppp6c", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 6 catalytic subunit", "refseq_ac": [ { "id": "NP_598273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598273", "type": "external" } ], "gene_names_uniprotkb": "Ppp6c; Ppv", "gene_names_refseq": "Ppp6c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 6 catalytic subunit; 3.1.3.16; PP-V; PP6C; Protein phosphatase V", "protein_names_refseq": "PP-V; PP6C; protein phosphatase V; serine/threonine-protein phosphatase 6 catalytic subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:171121); (R-RNO-171319); (R-RNO-204005)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8077208", "class_list": "", "function": "Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIG-I-mediated signaling activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ47", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045087 innate immune response;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006470 protein dephosphorylation;GO:0160049 negative regulation of cGAS/STING signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64620-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64709-1", "uniprot_id": [ { "id": "HLF_RAT", "url": "https://www.uniprot.org/uniprot/Q64709", "type": "external" } ], "mass": 33114.0, "length": 295, "protein_name": "Hepatic leukemia factor", "gene_name": "Hlf", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hlf", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatic leukemia factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "29393594;7556072", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64708", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0035914 skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64709-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H29-1", "uniprot_id": [ { "id": "GP160_RAT", "url": "https://www.uniprot.org/uniprot/Q66H29", "type": "external" } ], "mass": 38783.0, "length": 336, "protein_name": "Probable G protein-coupled receptor 160", "gene_name": "Gpr160", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 160", "refseq_ac": [ { "id": "NP_001020318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020318", "type": "external" } ], "gene_names_uniprotkb": "Gpr160", "gene_names_refseq": "Gpr160", "protein_names_uniprotkb": "Probable G protein-coupled receptor 160", "protein_names_refseq": "probable G-protein coupled receptor 160", "tax_id": 10116, "disease": "", "pathway": " (rno:499588)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34043767", "class_list": "", "function": "Orphan receptor., [UniProtKB]; Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise. Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H30-1", "uniprot_id": [ { "id": "GIN1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H30", "type": "external" } ], "mass": 58538.0, "length": 518, "protein_name": "Gypsy retrotransposon integrase-like protein 1", "gene_name": "GIN1; Gin1", "organism": "Rat", "refseq_name": "gypsy retrotransposon integrase-like protein 1", "refseq_ac": [ { "id": "NP_001020183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020183", "type": "external" } ], "gene_names_uniprotkb": "GIN1; Gin1", "gene_names_refseq": "Gin1; RGD1307449", "protein_names_uniprotkb": "Gypsy retrotransposon integrase-like protein 1; GIN-1", "protein_names_refseq": "GIN-1; gypsy retrotransposon integrase-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316687)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "", "go_biological_process": "GO:0015074 DNA integration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H58-1", "uniprot_id": [ { "id": "INT14_RAT", "url": "https://www.uniprot.org/uniprot/Q66H58", "type": "external" } ], "mass": 57144.0, "length": 515, "protein_name": "Integrator complex subunit 14", "gene_name": "Ints14", "organism": "Rat", "refseq_name": "integrator complex subunit 14", "refseq_ac": [ { "id": "NP_001007664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007664", "type": "external" } ], "gene_names_uniprotkb": "Ints14; Vwa9", "gene_names_refseq": "Ints14; RGD1359616; Vwa9", "protein_names_uniprotkb": "Integrator complex subunit 14; von Willebrand factor A domain-containing protein 9", "protein_names_refseq": "UPF0464 protein C15orf44 homolog; integrator complex subunit 14; von Willebrand factor A domain containing 9; von Willebrand factor A domain-containing protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:300782); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0016180 snRNA processing;GO:0034472 snRNA 3'-end processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H58-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H59-1", "uniprot_id": [ { "id": "NPL_RAT", "url": "https://www.uniprot.org/uniprot/Q66H59", "type": "external" } ], "mass": 35115.0, "length": 320, "protein_name": "N-acetylneuraminate lyase", "gene_name": "Npl", "organism": "Rat", "refseq_name": "N-acetylneuraminate lyase", "refseq_ac": [ { "id": "NP_001014006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014006", "type": "external" } ], "gene_names_uniprotkb": "Npl", "gene_names_refseq": "Npl", "protein_names_uniprotkb": "N-acetylneuraminate lyase; 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase", "protein_names_refseq": "N-acetylneuraminate lyase; N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase", "tax_id": 10116, "disease": "myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:304860); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008747 N-acetylneuraminate lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019262 N-acetylneuraminate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H59-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HA8-1", "uniprot_id": [ { "id": "HS105_RAT", "url": "https://www.uniprot.org/uniprot/Q66HA8", "type": "external" } ], "mass": 96419.0, "length": 858, "protein_name": "Heat shock protein 105 kDa", "gene_name": "Hsph1", "organism": "Rat", "refseq_name": "heat shock protein 105 kDa", "refseq_ac": [ { "id": "NP_001011901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011901", "type": "external" } ], "gene_names_uniprotkb": "Hsph1; Hsp105; Hsp110", "gene_names_refseq": "Hsp105; Hsph1", "protein_names_uniprotkb": "Heat shock protein 105 kDa; Heat shock 110 kDa protein", "protein_names_refseq": "heat shock 105/110 protein 1; heat shock 105kDa/110kDa protein 1; heat shock 105kDa; heat shock 110 kDa protein; heat shock protein 105 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:288444); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18683930;22673903", "class_list": "", "function": "Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043014 alpha-tubulin binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903748 negative regulation of establishment of protein localization to mitochondrion;GO:0051135 positive regulation of NK T cell activation;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061098 positive regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66HA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HB3-1", "uniprot_id": [ { "id": "IFT80_RAT", "url": "https://www.uniprot.org/uniprot/Q66HB3", "type": "external" } ], "mass": 87780.0, "length": 777, "protein_name": "Intraflagellar transport protein 80 homolog", "gene_name": "Ift80", "organism": "Rat", "refseq_name": "intraflagellar transport protein 80 homolog isoform 1", "refseq_ac": [ { "id": "NP_001013933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013933", "type": "external" } ], "gene_names_uniprotkb": "Ift80; Wdr56", "gene_names_refseq": "Ift80; RGD1312006; Wdr56", "protein_names_uniprotkb": "Intraflagellar transport protein 80 homolog; WD repeat-containing protein 56", "protein_names_refseq": "WD repeat domain 56; WD repeat-containing protein 56; intraflagellar transport 80 homolog; intraflagellar transport protein 80 homolog isoform 1; intraflagellar transport protein 80 homolog", "tax_id": 10116, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); ciliopathy (Disease Ontology:DOID:0060340); asphyxiating thoracic dystrophy 2 (Disease Ontology:DOID:0110086); asphyxiating thoracic dystrophy 3 (Disease Ontology:DOID:0110087)", "pathway": " (rno:295106); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0033687 osteoblast proliferation;GO:0008283 cell population proliferation;GO:0021510 spinal cord development;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HB3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HE2-1", "uniprot_id": [ { "id": "MOT13_RAT", "url": "https://www.uniprot.org/uniprot/Q66HE2", "type": "external" } ], "mass": 44993.0, "length": 428, "protein_name": "Monocarboxylate transporter 13", "gene_name": "Slc16a13", "organism": "Rat", "refseq_name": "monocarboxylate transporter 13", "refseq_ac": [ { "id": "NP_001005530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005530", "type": "external" } ], "gene_names_uniprotkb": "Slc16a13; Mct13", "gene_names_refseq": "Slc16a13", "protein_names_uniprotkb": "Monocarboxylate transporter 13; MCT 13; Solute carrier family 16 member 13", "protein_names_refseq": "MCT 13; monocarboxylate transporter 13; solute carrier family 16 (monocarboxylic acid transporters), member 13; solute carrier family 16, member 13 (monocarboxylic acid transporter 13)", "tax_id": 10116, "disease": "", "pathway": " (rno:287451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HF1-1", "uniprot_id": [ { "id": "NDUS1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HF1", "type": "external" } ], "mass": 79412.0, "length": 727, "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "Ndufs1", "organism": "Rat", "refseq_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550", "type": "external" } ], "gene_names_uniprotkb": "Ndufs1", "gene_names_refseq": "Ndufs1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; 7.1.1.2", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 5 (Disease Ontology:DOID:0112068); inherited metabolic disorder (Disease Ontology:DOID:655); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:301458); (R-RNO-611105); (R-RNO-6799198); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "18683930;21752959;26446791;27213235;34502162;36402252;38843836", "class_list": "", "function": "A critical postnatal accumulation of oxidatively damaged respiratory complex I occurs in the cerebellum following prenatal exposure to all-trans retinoic acid., [RefSeq, PubMed]; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0045333 cellular respiration;GO:0042773 ATP synthesis coupled electron transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q66HF1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG1-1", "uniprot_id": [ { "id": "DMTF1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG1", "type": "external" } ], "mass": 84452.0, "length": 760, "protein_name": "Cyclin-D-binding Myb-like transcription factor 1", "gene_name": "Dmtf1", "organism": "Rat", "refseq_name": "cyclin-D-binding Myb-like transcription factor 1 isoform 2", "refseq_ac": [ { "id": "NP_446145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446145", "type": "external" } ], "gene_names_uniprotkb": "Dmtf1", "gene_names_refseq": "Dmtf1", "protein_names_uniprotkb": "Cyclin-D-binding Myb-like transcription factor 1", "protein_names_refseq": "cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin-D-binding Myb-like transcription factor 1 isoform 2; cyclin-D-binding Myb-like transcription factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:114485)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11707776", "class_list": "", "function": "Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99MC8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q672K1-1", "uniprot_id": [ { "id": "NOX3_RAT", "url": "https://www.uniprot.org/uniprot/Q672K1", "type": "external" } ], "mass": 64416.0, "length": 568, "protein_name": "NADPH oxidase 3", "gene_name": "Nox3", "organism": "Rat", "refseq_name": "NADPH oxidase 3", "refseq_ac": [ { "id": "NP_001004216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004216", "type": "external" } ], "gene_names_uniprotkb": "Nox3", "gene_names_refseq": "Nox3", "protein_names_uniprotkb": "NADPH oxidase 3; 1.6.3.-", "protein_names_refseq": "NADPH oxidase 3; superoxide producing enzyme", "tax_id": 10116, "disease": "", "pathway": " (rno:292279); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15326186;19052196;20214492;26830484", "class_list": "", "function": "NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor, upon formation of a complex with CYBA/p22phox (By similarity). Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity)., [UniProtKB, UniProtKB]; NOX3 is a relevant source of ROS generation in the cochlear and vestibular systems and that NOX3-dependent ROS generation might contribute to hearing loss and balance problems in response to ototoxic drugs., [RefSeq, PubMed]; NOX3 regulates stress-related genes in the cochlea, such as TRPV1 and KIM-1, and initiates apoptosis in the cochlea., [RefSeq, PubMed]; These data provide a link between NOX3 and TRPV1 in cisplatin-induced hearing loss and suggest that targeting these proteins for knockdown by siRNA could serve as a novel approach in treating cisplatin ototoxicity., [RefSeq, PubMed]; These results suggested that the high expression levels of NOX3 increased oxidative stress in stroke-prone hypertensive rat cerebrum., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009590 detection of gravity;GO:0001659 temperature homeostasis;GO:0006952 defense response;GO:0048840 otolith development;GO:0009629 response to gravity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q672K1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FP2-1", "uniprot_id": [ { "id": "PON3_RAT", "url": "https://www.uniprot.org/uniprot/Q68FP2", "type": "external" } ], "mass": 39458.0, "length": 354, "protein_name": "Serum paraoxonase/lactonase 3", "gene_name": "Pon3", "organism": "Rat", "refseq_name": "serum paraoxonase/lactonase 3", "refseq_ac": [ { "id": "NP_001004086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004086", "type": "external" } ], "gene_names_uniprotkb": "Pon3", "gene_names_refseq": "Pon3", "protein_names_uniprotkb": "Serum paraoxonase/lactonase 3; 3.1.1.2; 3.1.1.81; 3.1.8.1", "protein_names_refseq": "serum paraoxonase/lactonase 3", "tax_id": 10116, "disease": "celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); atherosclerosis (Disease Ontology:DOID:1936); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:312086); (R-RNO-2142688); (R-RNO-9754706)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12946270;19091700;21454685", "class_list": "", "function": "Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity)., [UniProtKB]; Purification and characterization of paraoxonase 3 (Pon3) from liver microsomes., [RefSeq, PubMed]; Study documented, for the first time, the presence of PON3 in rat serum and, notably, found that the upregulation of PON3, rather than PON1, appears to be associated with physical training., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.81", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0047856 dihydrocoumarin hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0046395 carboxylic acid catabolic process;GO:0010124 phenylacetate catabolic process;GO:0032929 negative regulation of superoxide anion generation;GO:0009636 response to toxic substance;GO:0046226 coumarin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FP2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FP8-1", "uniprot_id": [ { "id": "KAD8_RAT", "url": "https://www.uniprot.org/uniprot/Q68FP8", "type": "external" } ], "mass": 54966.0, "length": 479, "protein_name": "Adenylate kinase 8", "gene_name": "Ak8", "organism": "Rat", "refseq_name": "adenylate kinase 8", "refseq_ac": [ { "id": "NP_001004266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004266", "type": "external" } ], "gene_names_uniprotkb": "Ak8", "gene_names_refseq": "AK 8; Ak8; RGD1303144", "protein_names_uniprotkb": "Adenylate kinase 8; 2.7.4.3; 2.7.4.6; AK 8; ATP-AMP transphosphorylase 8", "protein_names_refseq": "ATP-AMP transphosphorylase 8; HypB, AroK, ADK and rho factor domain containing protein RGD1303144; adenylate kinase 8; putative adenylate kinase-like protein C9orf98 homolog", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:311833); (R-RNO-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016208 AMP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium", "go_biological_process": "GO:0021591 ventricular system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FP8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR6-1", "uniprot_id": [ { "id": "EF1G_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR6", "type": "external" } ], "mass": 50061.0, "length": 437, "protein_name": "Elongation factor 1-gamma", "gene_name": "Eef1g", "organism": "Rat", "refseq_name": "elongation factor 1-gamma", "refseq_ac": [ { "id": "NP_001004223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004223", "type": "external" } ], "gene_names_uniprotkb": "Eef1g", "gene_names_refseq": "Eef1g", "protein_names_uniprotkb": "Elongation factor 1-gamma; EF-1-gamma; eEF-1B gamma", "protein_names_refseq": "EF-1-gamma; eEF-1B gamma; elongation factor 1-gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:293725); (R-RNO-156842)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably plays a role in anchoring the complex to other cellular components., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZZ5", "ec_number_list": [], "go_molecular_function": "GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009615 response to virus;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FR6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR7-1", "uniprot_id": [ { "id": "LTV1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR7", "type": "external" } ], "mass": 53562.0, "length": 470, "protein_name": "Protein LTV1 homolog", "gene_name": "Ltv1", "organism": "Rat", "refseq_name": "protein LTV1 homolog", "refseq_ac": [ { "id": "NP_001014179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014179", "type": "external" } ], "gene_names_uniprotkb": "Ltv1", "gene_names_refseq": "Ltv1; RGD1311264", "protein_names_uniprotkb": "Protein LTV1 homolog", "protein_names_refseq": "LTV1 homolog; protein LTV1 homolog", "tax_id": 10116, "disease": "inflammatory poikiloderma with hair abnormalities and acral keratoses (Disease Ontology:DOID:0070510)", "pathway": " (rno:361452); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for ribosome biogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000056 ribosomal small subunit export from nucleus;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FR7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX0-1", "uniprot_id": [ { "id": "IDH3B_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX0", "type": "external" } ], "mass": 42354.0, "length": 385, "protein_name": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "gene_name": "Idh3B; Idh3b", "organism": "Rat", "refseq_name": "isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_446033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446033", "type": "external" } ], "gene_names_uniprotkb": "Idh3B; Idh3b", "gene_names_refseq": "Idh3b", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit beta", "protein_names_refseq": "NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit; isocitrate dehydrogenase (NAD(+)) 3 beta; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 precursor; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitric dehydrogenase subunit beta", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 46 (Disease Ontology:DOID:0110409)", "pathway": " (rno:94173); (R-RNO-71403)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27213235", "class_list": "", "function": "Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008047 enzyme activator activity;GO:0051287 NAD binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXM8-1", "uniprot_id": [ { "id": "PON2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXM8", "type": "external" } ], "mass": 39617.0, "length": 354, "protein_name": "Serum paraoxonase/arylesterase 2", "gene_name": "Pon2", "organism": "Rat", "refseq_name": "serum paraoxonase/arylesterase 2", "refseq_ac": [ { "id": "NP_001013100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013100", "type": "external" } ], "gene_names_uniprotkb": "Pon2", "gene_names_refseq": "Pon2", "protein_names_uniprotkb": "Serum paraoxonase/arylesterase 2; 3.1.1.2; 3.1.1.81; A-esterase 2; Aromatic esterase 2; PON 2; Serum aryldialkylphosphatase 2", "protein_names_refseq": "A-esterase 2; PON 2; aromatic esterase 2; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); familial hypercholesterolemia (Disease Ontology:DOID:13810); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:296851); (R-RNO-2142688)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21454685;25842176", "class_list": "", "function": "Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters., [UniProtKB]; Lovastatin conferred neuroprotection against MPP(+)-induced Parkinson disease but this effect was not associated with the induction of PON2 in the rat striatum., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.81", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004064 arylesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009636 response to toxic substance;GO:1901335 lactone catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXM8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXS0-1", "uniprot_id": [ { "id": "NCLX_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXS0", "type": "external" } ], "mass": 63992.0, "length": 585, "protein_name": "Mitochondrial sodium/calcium exchanger protein", "gene_name": "Slc8b1", "organism": "Rat", "refseq_name": "mitochondrial sodium/calcium exchanger protein precursor", "refseq_ac": [ { "id": "NP_001017488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017488", "type": "external" } ], "gene_names_uniprotkb": "Slc8b1; Nckx6; Nclx; Slc24a6", "gene_names_refseq": "Slc24a6; Slc8b1", "protein_names_uniprotkb": "Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 member 6; Solute carrier family 8 member B1", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 6; mitochondrial sodium/calcium exchanger protein precursor; mitochondrial sodium/calcium exchanger protein; sodium/calcium exchanger protein, mitochondrial; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 member 6; solute carrier family 8 (sodium/lithium/calcium exchanger), member B1", "tax_id": 10116, "disease": "", "pathway": " (rno:498185); (R-RNO-425561); (R-RNO-8949215)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "14625281;15060069;20018762;29223733;40931067", "class_list": "", "function": "Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (By similarity). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (PubMed:40931067). Mitochondrial calcium export is ph-dependent (PubMed:40931067). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (By similarity). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (By similarity). In contrast to other members of the family its function is independent of K(+) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Neurons display reduced levels of the mitochondrial calcium transporter NCLX that can be restored by calcium-chelating agents and by external addition of frataxin fused to TAT peptide, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005432 calcium:sodium antiporter activity;GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AXS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU3-1", "uniprot_id": [ { "id": "I20L2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU3", "type": "external" } ], "mass": 41311.0, "length": 369, "protein_name": "Interferon-stimulated 20 kDa exonuclease-like 2", "gene_name": "Isg20l2", "organism": "Rat", "refseq_name": "interferon-stimulated 20 kDa exonuclease-like 2", "refseq_ac": [ { "id": "NP_001007742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007742", "type": "external" } ], "gene_names_uniprotkb": "Isg20l2", "gene_names_refseq": "Isg20l2", "protein_names_uniprotkb": "Interferon-stimulated 20 kDa exonuclease-like 2; 3.1.-.-", "protein_names_refseq": "interferon-stimulated 20 kDa exonuclease-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361977); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0004527 exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006396 RNA processing;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXW1-1", "uniprot_id": [ { "id": "GLRX2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXW1", "type": "external" } ], "mass": 17275.0, "length": 157, "protein_name": "Glutaredoxin-2, mitochondrial", "gene_name": "Glrx2", "organism": "Rat", "refseq_name": "glutaredoxin-2, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001381099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381099", "type": "external" } ], "gene_names_uniprotkb": "Glrx2; Grx2", "gene_names_refseq": "Glrx2", "protein_names_uniprotkb": "Glutaredoxin-2, mitochondrial", "protein_names_refseq": "glutaredoxin 2 (thioltransferase); glutaredoxin-2, mitochondrial isoform 1; glutaredoxin-2, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:114022)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11397793;20929858;25735211", "class_list": "", "function": "Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3., [RefSeq, PubMed]; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity)., [UniProtKB]; Grx2 and Trx1 contribute significantly to neuronal integrity and could be clinically relevant in neuronal damage following perinatal asphyxia and other neuronal disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030425 dendrite", "go_biological_process": "GO:0071451 cellular response to superoxide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AXW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY0-1", "uniprot_id": [ { "id": "GSTA6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY0", "type": "external" } ], "mass": 25808.0, "length": 222, "protein_name": "Glutathione S-transferase A6", "gene_name": "Gsta6", "organism": "Rat", "refseq_name": "glutathione S-transferase A6", "refseq_ac": [ { "id": "NP_001019532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019532", "type": "external" } ], "gene_names_uniprotkb": "Gsta6", "gene_names_refseq": "Gsta6", "protein_names_uniprotkb": "Glutathione S-transferase A6; 2.5.1.18; GST class-alpha member 6", "protein_names_refseq": "GST class-alpha member 6; glutathione S-transferase A6", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:501110); (R-RNO-156590); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXY0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY04-1", "uniprot_id": [ { "id": "MAIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY04", "type": "external" } ], "mass": 33090.0, "length": 291, "protein_name": "m-AAA protease-interacting protein 1, mitochondrial", "gene_name": "Maip1", "organism": "Rat", "refseq_name": "m-AAA protease-interacting protein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001004251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004251", "type": "external" } ], "gene_names_uniprotkb": "Maip1", "gene_names_refseq": "Maip1", "protein_names_uniprotkb": "m-AAA protease-interacting protein 1, mitochondrial; Matrix AAA peptidase-interacting protein 1", "protein_names_refseq": "m-AAA protease-interacting protein 1, mitochondrial precursor; m-AAA protease-interacting protein 1, mitochondrial; uncharacterized protein C2orf47 homolog, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:301418); (R-RNO-8949664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0051204 protein insertion into mitochondrial membrane;GO:0032979 protein insertion into mitochondrial inner membrane from matrix", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY20-1", "uniprot_id": [ { "id": "MPRD_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY20", "type": "external" } ], "mass": 31095.0, "length": 278, "protein_name": "Cation-dependent mannose-6-phosphate receptor", "gene_name": "M6pr", "organism": "Rat", "refseq_name": "cation-dependent mannose-6-phosphate receptor precursor", "refseq_ac": [ { "id": "NP_001007701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007701", "type": "external" } ], "gene_names_uniprotkb": "M6pr", "gene_names_refseq": "M6pr", "protein_names_uniprotkb": "Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR", "protein_names_refseq": "CD Man-6-P receptor; CD-MPR; cation-dependent mannose-6-phosphate receptor precursor; cation-dependent mannose-6-phosphate receptor-like; cation-dependent mannose-6-phosphate receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:312689); (R-RNO-432720); (R-RNO-6811440); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9840310)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "16085051;20564206;21640079;22673903;23290006;24090084", "class_list": "", "function": "Data show that the CD-MPR might be regulated by hormones and that this receptor might be involved in the secretion of specific enzymes into the rat epididymis., [RefSeq, PubMed]; Expression and distribution of CD-MPR is affected by decrease of testosterone in the epididymis, and this could change the distribution of lysosomal enzymes, [RefSeq, PubMed]; The distribution of the cation-independent mannose 6-phosphate receptors was studied in postnuclear subcellular fractions from two rat liver cell lines., [RefSeq, PubMed]; This evidence may also suggest that CD-MPR and CI-MPR have different functions, mainly at early stages in the development of organs., [RefSeq, PubMed]; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane;GO:0005770 late endosome;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006622 protein targeting to lysosome;GO:0007041 lysosomal transport;GO:0033299 secretion of lysosomal enzymes", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q6AY20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY80-1", "uniprot_id": [ { "id": "NQO2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY80", "type": "external" } ], "mass": 26275.0, "length": 231, "protein_name": "Ribosyldihydronicotinamide dehydrogenase [quinone]", "gene_name": "Nqo2", "organism": "Rat", "refseq_name": "ribosyldihydronicotinamide dehydrogenase [quinone]", "refseq_ac": [ { "id": "NP_001004214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004214", "type": "external" } ], "gene_names_uniprotkb": "Nqo2", "gene_names_refseq": "Nqo2", "protein_names_uniprotkb": "Ribosyldihydronicotinamide dehydrogenase [quinone]; 1.10.5.1; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; Quinone reductase 2", "protein_names_refseq": "N-ribosyldihydronicotinamide:quinone reductase 2; NAD(P)H dehydrogenase, quinone 2; NAD(P)H quinone dehydrogenase 2; NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; QR2; ribosyldihydronicotinamide dehydrogenase [quinone]; ribosyldihydronicotinamide dehydrogenase", "tax_id": 10116, "disease": "agranulocytosis (Disease Ontology:DOID:12987); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:291084); (R-RNO-211945)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20861374;22508052;36650666", "class_list": "", "function": "Downregulation of NQO2 significantly suppresses vascular smooth muscle cell proliferation and progression of neointimal formation after vascular injury., [RefSeq, PubMed]; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis., [UniProtKB, UniProtKB, UniProtKB]; The influence of NQO2 on the dysfunctional autophagy and oxidative stress induced in the hippocampus of rats and in SH-SY5Y cells by fluoride., [RefSeq, PubMed]; These data suggest a role for QR2 in cognitive behaviors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.10.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.5.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0009055 electron transfer activity;GO:0042803 protein homodimerization activity;GO:0071949 FAD binding;GO:0031404 chloride ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0007613 memory;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:2000379 positive regulation of reactive oxygen species metabolic process;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AY80-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY88-1", "uniprot_id": [ { "id": "KDF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY88", "type": "external" } ], "mass": 43445.0, "length": 397, "protein_name": "Keratinocyte differentiation factor 1", "gene_name": "Kdf1", "organism": "Rat", "refseq_name": "keratinocyte differentiation factor 1", "refseq_ac": [ { "id": "NP_001004268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004268", "type": "external" } ], "gene_names_uniprotkb": "Kdf1", "gene_names_refseq": "Kdf1; RGD1303271", "protein_names_uniprotkb": "Keratinocyte differentiation factor 1", "protein_names_refseq": "keratinocyte differentiation factor 1; uncharacterized protein C1orf172 homolog", "tax_id": 10116, "disease": "ectodermal dysplasia 12 (Disease Ontology:DOID:0111652)", "pathway": " (rno:313018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0030054 cell junction;GO:0031252 cell leading edge;GO:0070161 anchoring junction", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0060887 limb epidermis development;GO:2000647 negative regulation of stem cell proliferation;GO:0016579 protein deubiquitination;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY88-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYA1-1", "uniprot_id": [ { "id": "GAR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYA1", "type": "external" } ], "mass": 23011.0, "length": 226, "protein_name": "H/ACA ribonucleoprotein complex subunit 1", "gene_name": "Gar1", "organism": "Rat", "refseq_name": "H/ACA ribonucleoprotein complex subunit 1", "refseq_ac": [ { "id": "NP_001019477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019477", "type": "external" } ], "gene_names_uniprotkb": "Gar1; Nola1", "gene_names_refseq": "Gar1; Nola1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 1; Nucleolar protein family A member 1; snoRNP protein GAR1", "protein_names_refseq": "GAR1 homolog, ribonucleoprotein; GAR1 ribonucleoprotein homolog; H/ACA ribonucleoprotein complex subunit 1; nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1", "tax_id": 10116, "disease": "", "pathway": " (rno:499709); (R-RNO-171319); (R-RNO-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (`psi`) residues may serve to stabilize the conformation of rRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0090661 box H/ACA telomerase RNP complex", "go_biological_process": "GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0006364 rRNA processing;GO:0001522 pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYB4-1", "uniprot_id": [ { "id": "HSP7E_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYB4", "type": "external" } ], "mass": 54463.0, "length": 509, "protein_name": "Heat shock 70 kDa protein 14", "gene_name": "Hspa14", "organism": "Rat", "refseq_name": "heat shock 70 kDa protein 14", "refseq_ac": [ { "id": "NP_001004257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004257", "type": "external" } ], "gene_names_uniprotkb": "Hspa14", "gene_names_refseq": "Hspa14", "protein_names_uniprotkb": "Heat shock 70 kDa protein 14", "protein_names_refseq": "heat shock 70 kDa protein 14; heat shock 70kDa protein 14; heat shock protein 14; heat shock protein family A, member 14; heat shock protein hsp70-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:307133); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005840 ribosome", "go_biological_process": "GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYB4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF4-1", "uniprot_id": [ { "id": "ITB6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF4", "type": "external" } ], "mass": 85959.0, "length": 787, "protein_name": "Integrin beta-6", "gene_name": "Itgb6", "organism": "Rat", "refseq_name": "integrin beta-6 precursor", "refseq_ac": [ { "id": "NP_001004263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004263", "type": "external" } ], "gene_names_uniprotkb": "Itgb6", "gene_names_refseq": "Itgb6", "protein_names_uniprotkb": "Integrin beta-6", "protein_names_refseq": "integrin beta 6; integrin beta-6 precursor", "tax_id": 10116, "disease": "amelogenesis imperfecta type 1H (Disease Ontology:DOID:0110064); cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:311061); (R-RNO-1566948); (R-RNO-2129379); (R-RNO-216083); (R-RNO-2173789); (R-RNO-3000178)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "23422496;26279426;36307995", "class_list": "", "function": "Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats., [RefSeq, PubMed]; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Integrin alphavbeta6 is strongly induced de novo in newly formed bile ducts because of cholangiocyte proliferation during ischemia-related biliary fibrogenesis after liver transplantation., [RefSeq, PubMed]; These data support the hypothesis that IL-1beta was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0015026 coreceptor activity;GO:0046872 metal ion binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0034685 integrin alphav-beta6 complex", "go_biological_process": "GO:0060435 bronchiole development;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH6-1", "uniprot_id": [ { "id": "EMC10_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH6", "type": "external" } ], "mass": 26968.0, "length": 258, "protein_name": "ER membrane protein complex subunit 10", "gene_name": "Emc10", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 10 precursor", "refseq_ac": [ { "id": "NP_001004221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004221", "type": "external" } ], "gene_names_uniprotkb": "Emc10; Inm02", "gene_names_refseq": "Emc10; Inm02", "protein_names_uniprotkb": "ER membrane protein complex subunit 10", "protein_names_refseq": "ER membrane protein complex subunit 10 precursor; UPF0510 protein INM02", "tax_id": 10116, "disease": "", "pathway": " (rno:292878)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19570817;24090084", "class_list": "", "function": "As a novel secreted protein, INM02 (MGC93975) is associated with functions of pancreatic islets, especially of beta-cells, [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0005576 extracellular region;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AYH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYI2-1", "uniprot_id": [ { "id": "KLDC3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYI2", "type": "external" } ], "mass": 43109.0, "length": 382, "protein_name": "Kelch domain-containing protein 3", "gene_name": "Klhdc3", "organism": "Rat", "refseq_name": "kelch domain-containing protein 3", "refseq_ac": [ { "id": "NP_001012203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012203", "type": "external" } ], "gene_names_uniprotkb": "Klhdc3", "gene_names_refseq": "Klhdc3", "protein_names_uniprotkb": "Kelch domain-containing protein 3", "protein_names_refseq": "kelch domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:363192)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons. The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine. May be involved in meiotic recombination process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0051321 meiotic cell cycle;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL2-1", "uniprot_id": [ { "id": "GSG1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL2", "type": "external" } ], "mass": 36057.0, "length": 325, "protein_name": "Germ cell-specific gene 1 protein", "gene_name": "Gsg1", "organism": "Rat", "refseq_name": "germ cell-specific gene 1 protein", "refseq_ac": [ { "id": "NP_001013184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013184", "type": "external" } ], "gene_names_uniprotkb": "Gsg1", "gene_names_refseq": "Gsg1", "protein_names_uniprotkb": "Germ cell-specific gene 1 protein", "protein_names_refseq": "germ cell-specific gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:312793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYL2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYQ1-1", "uniprot_id": [ { "id": "GOGA7_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYQ1", "type": "external" } ], "mass": 15778.0, "length": 137, "protein_name": "Golgin subfamily A member 7", "gene_name": "Golga7", "organism": "Rat", "refseq_name": "golgin subfamily A member 7", "refseq_ac": [ { "id": "NP_001007732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007732", "type": "external" } ], "gene_names_uniprotkb": "Golga7", "gene_names_refseq": "Golga7", "protein_names_uniprotkb": "Golgin subfamily A member 7", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 7; golgin subfamily A member 7", "tax_id": 10116, "disease": "", "pathway": " (rno:361171); (R-RNO-6798695); (R-RNO-9648002)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0002178 palmitoyltransferase complex", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006612 protein targeting to membrane;GO:0043001 Golgi to plasma membrane protein transport;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT2-1", "uniprot_id": [ { "id": "NFE2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT2", "type": "external" } ], "mass": 41496.0, "length": 373, "protein_name": "Transcription factor NF-E2 45 kDa subunit", "gene_name": "Nfe2", "organism": "Rat", "refseq_name": "transcription factor NF-E2 45 kDa subunit", "refseq_ac": [ { "id": "NP_001012224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012224", "type": "external" } ], "gene_names_uniprotkb": "Nfe2", "gene_names_refseq": "Nfe2", "protein_names_uniprotkb": "Transcription factor NF-E2 45 kDa subunit; Leucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2", "protein_names_refseq": "leucine zipper protein NF-E2; nuclear factor, erythroid derived 2; nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2; transcription factor NF-E2 45 kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:366998); (R-RNO-983231)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25007950;29802941", "class_list": "", "function": "Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity)., [UniProtKB]; NFE2/miR432-5p is reduced and FAM3a is increased with exercise in a rat model of insulin sensitivity Erratum:[Life Sci. 2020 Nov 1;260:118515. doi: 10.1016/j.lfs.2020.118515. PMID: 33039124], [RefSeq, PubMed]; Nrf2 silencing induced anxiety-related behavior in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0008285 negative regulation of cell population proliferation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYU4-1", "uniprot_id": [ { "id": "EGLN2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYU4", "type": "external" } ], "mass": 44681.0, "length": 415, "protein_name": "Prolyl hydroxylase EGLN2", "gene_name": "Egln2", "organism": "Rat", "refseq_name": "prolyl hydroxylase EGLN2", "refseq_ac": [ { "id": "NP_001004083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004083", "type": "external" } ], "gene_names_uniprotkb": "Egln2", "gene_names_refseq": "Egln2; HIF-PH1; HPH-1; HPH-3; PHD-1; PHD1", "protein_names_uniprotkb": "Prolyl hydroxylase EGLN2; 1.14.11.-; 1.14.11.29; Egl nine homolog 2; HIF-PH1; HIF-prolyl hydroxylase 1; HPH-1; HPH-3; Hypoxia-inducible factor prolyl hydroxylase 1; PHD1; Prolyl hydroxylase domain-containing protein 1", "protein_names_refseq": "HIF-1alpha prolyl-4-hydroxylase-1; HIF-prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase EGLN2; prolyl hydroxylase domain-containing protein 1", "tax_id": 10116, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:308457); (R-RNO-1234176)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15925519;16765982;22351621;29030976;29393594;34687132", "class_list": "", "function": "In conclusion, a low-level laser could modulate HIF-1alpha activity in nerve entrapment neuropathy, [RefSeq, PubMed]; LncRNA MIAT enhances cerebral ischaemia/reperfusion injury in rat model via interacting with EGLN2 and reduces its ubiquitin-mediated degradation., [RefSeq, PubMed]; Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:15925519). Target proteins are preferentially recognized via a LXXLAP motif (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:15925519). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity). Also hydroxylates HIF2A (By similarity). Has a preference for the CODD site for both HIF1A and HIF2A (By similarity). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (By similarity). Also regulates susceptibility to normoxic oxidative neuronal death (By similarity). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; That combined function of HIF-1alpha and FoxO3a under high glucose plus hypoxia condition lead to enhanced expression of BNIP3 inducing cardiomyocyte death, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0031545 peptidyl-proline 4-dioxygenase activity;GO:0019826 oxygen sensor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0045454 cell redox homeostasis;GO:0045732 positive regulation of protein catabolic process;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6AYU4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ51-1", "uniprot_id": [ { "id": "I17RE_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ51", "type": "external" } ], "mass": 70852.0, "length": 637, "protein_name": "Interleukin-17 receptor E", "gene_name": "Il17re", "organism": "Rat", "refseq_name": "interleukin-17 receptor E precursor", "refseq_ac": [ { "id": "NP_001004091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004091", "type": "external" } ], "gene_names_uniprotkb": "Il17re", "gene_names_refseq": "Il17re", "protein_names_uniprotkb": "Interleukin-17 receptor E; IL-17 receptor E; IL-17RE", "protein_names_refseq": "IL-17 receptor E; IL-17RE; interleukin-17 receptor E precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:362417)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7B8", "ec_number_list": [], "go_molecular_function": "GO:0030368 interleukin-17 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AZ51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6BEA2-1", "uniprot_id": [ { "id": "PRS27_RAT", "url": "https://www.uniprot.org/uniprot/Q6BEA2", "type": "external" } ], "mass": 35803.0, "length": 328, "protein_name": "Serine protease 27", "gene_name": "Prss27", "organism": "Rat", "refseq_name": "serine protease 27 precursor", "refseq_ac": [ { "id": "NP_891994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891994", "type": "external" } ], "gene_names_uniprotkb": "Prss27; Mpn", "gene_names_refseq": "Mpn; Prss27", "protein_names_uniprotkb": "Serine protease 27; 3.4.21.-; Marapsin; Pancreasin", "protein_names_refseq": "marapsin; pancreasin; protease, serine 27; serine protease 27 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:287108)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6BEA2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DLV9-1", "uniprot_id": [ { "id": "PCGF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6DLV9", "type": "external" } ], "mass": 28782.0, "length": 243, "protein_name": "Polycomb group RING finger protein 1", "gene_name": "Pcgf1", "organism": "Rat", "refseq_name": "polycomb group RING finger protein 1", "refseq_ac": [ { "id": "NP_001007001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007001", "type": "external" } ], "gene_names_uniprotkb": "Pcgf1; Nspc1", "gene_names_refseq": "Nspc1; Pcgf1", "protein_names_uniprotkb": "Polycomb group RING finger protein 1; NSPc1; Nervous system Polycomb-1", "protein_names_refseq": "nervous system Polycomb-1; nervous system polycomb 1; polycomb group RING finger protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312480)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15620699", "class_list": "", "function": "Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6DLV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GX84-1", "uniprot_id": [ { "id": "FIGL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6GX84", "type": "external" } ], "mass": 74197.0, "length": 677, "protein_name": "Fidgetin-like protein 1", "gene_name": "Fignl1", "organism": "Rat", "refseq_name": "fidgetin-like protein 1", "refseq_ac": [ { "id": "NP_001011913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011913", "type": "external" } ], "gene_names_uniprotkb": "Fignl1; S30", "gene_names_refseq": "Fignl1", "protein_names_uniprotkb": "Fidgetin-like protein 1; 3.6.4.-", "protein_names_refseq": "fidgetin-like protein 1", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (rno:289777); (R-RNO-5693568); (R-RNO-912446)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16288221", "class_list": "", "function": "ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases. Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000228 nuclear chromosome;GO:1990391 DNA repair complex", "go_biological_process": "GO:0033687 osteoblast proliferation;GO:0051013 microtubule severing;GO:0043066 negative regulation of apoptotic process;GO:0001649 osteoblast differentiation;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6GX84-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE63-1", "uniprot_id": [ { "id": "PRS46_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE63", "type": "external" } ], "mass": 34999.0, "length": 314, "protein_name": "Serine protease 46", "gene_name": "Prss46", "organism": "Rat", "refseq_name": "serine protease 46", "refseq_ac": [ { "id": "NP_001008865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008865", "type": "external" } ], "gene_names_uniprotkb": "Prss46; Tessp6", "gene_names_refseq": "Prss46; Tessp6", "protein_names_uniprotkb": "Serine protease 46; 3.4.21.-; Testis-specific serine protease-6", "protein_names_refseq": "serine protease 46; testis-specific serine protease-6", "tax_id": 10116, "disease": "", "pathway": " (rno:408245)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFU7-1", "uniprot_id": [ { "id": "K1C42_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFU7", "type": "external" } ], "mass": 50213.0, "length": 452, "protein_name": "Keratin, type I cytoskeletal 42", "gene_name": "Krt42", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 42", "refseq_ac": [ { "id": "NP_001008816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008816", "type": "external" } ], "gene_names_uniprotkb": "Krt42; Ka22", "gene_names_refseq": "Ka22; Krt42", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 42; CK-42; Cytokeratin-42; K42; Keratin-42; Type I keratin Ka22", "protein_names_refseq": "CK-42; K42; cytokeratin-42; keratin, type I cytoskeletal 42; type I keratin KA22", "tax_id": 10116, "disease": "", "pathway": " (rno:450231)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15085952;34502162", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IFU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IG04-1", "uniprot_id": [ { "id": "K2C72_RAT", "url": "https://www.uniprot.org/uniprot/Q6IG04", "type": "external" } ], "mass": 56851.0, "length": 520, "protein_name": "Keratin, type II cytoskeletal 72", "gene_name": "Krt72", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 72", "refseq_ac": [ { "id": "NP_001008809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008809", "type": "external" } ], "gene_names_uniprotkb": "Krt72; Kb35", "gene_names_refseq": "Kb35; Krt72", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 72; CK-72; Cytokeratin-72; K72; Keratin-72; Type II inner root sheath-specific keratin-K6irs2; Type-II keratin Kb35", "protein_names_refseq": "CK-72; K72; cytokeratin-72; keratin 72, type II; keratin, type II cytoskeletal 72; type II inner root sheath-specific keratin-K6irs2; type II keratin Kb35; type-II keratin-35", "tax_id": 10116, "disease": "", "pathway": " (rno:406227); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IG04-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMF1-1", "uniprot_id": [ { "id": "K2C80_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMF1", "type": "external" } ], "mass": 50550.0, "length": 452, "protein_name": "Keratin, type II cytoskeletal 80", "gene_name": "Krt80", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 80", "refseq_ac": [ { "id": "NP_001008815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008815", "type": "external" } ], "gene_names_uniprotkb": "Krt80; Kb20", "gene_names_refseq": "Kb20; Kb2; Krt80", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 80; CK-80; Cytokeratin-80; K80; Keratin-80; Type-II keratin Kb20", "protein_names_refseq": "CK-80; K80; cytokeratin-80; keratin 80, type II; keratin, type II cytoskeletal 80; type II keratin-20; type-II keratin Kb20", "tax_id": 10116, "disease": "", "pathway": " (rno:315318); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15085952", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005882 intermediate filament;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMG5-1", "uniprot_id": [ { "id": "NHLC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMG5", "type": "external" } ], "mass": 42089.0, "length": 396, "protein_name": "E3 ubiquitin-protein ligase NHLRC1", "gene_name": "Nhlrc1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase NHLRC1", "refseq_ac": [ { "id": "NP_954706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954706", "type": "external" } ], "gene_names_uniprotkb": "Nhlrc1; Epm2b", "gene_names_refseq": "Epm2b; Nhlrc1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NHLRC1; 2.3.2.27; Malin; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1", "protein_names_refseq": "E3 ubiquitin-protein ligase NHLRC1; NHL repeat containing 1; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1; malin", "tax_id": 10116, "disease": "Lafora disease 2 (Disease Ontology:DOID:0061211); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (rno:364682)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12958597;29393594", "class_list": "", "function": "E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination;GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IMG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMX7-1", "uniprot_id": [ { "id": "HPBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMX7", "type": "external" } ], "mass": 39191.0, "length": 357, "protein_name": "Hsp70-binding protein 1", "gene_name": "Hspbp1", "organism": "Rat", "refseq_name": "hsp70-binding protein 1", "refseq_ac": [ { "id": "NP_640354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640354", "type": "external" } ], "gene_names_uniprotkb": "Hspbp1; Hspbp", "gene_names_refseq": "Hspbp1", "protein_names_uniprotkb": "Hsp70-binding protein 1; Heat shock protein-binding protein 1; Hsp70-interacting protein 1; HspBP1", "protein_names_refseq": "HSPA (heat shock 70) binding protein, cytoplasmic cochaperone 1; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1; HSPA binding protein, cytoplasmic cochaperone 1; heat shock protein-binding protein 1; hsp70-binding protein 1; hsp70-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:246146)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10786638;22673903", "class_list": "", "function": "Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLF4", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0000774 adenyl-nucleotide exchange factor activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IMX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMZ0-1", "uniprot_id": [ { "id": "NFIL3_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMZ0", "type": "external" } ], "mass": 50781.0, "length": 462, "protein_name": "Nuclear factor interleukin-3-regulated protein", "gene_name": "Nfil3", "organism": "Rat", "refseq_name": "nuclear factor interleukin-3-regulated protein", "refseq_ac": [ { "id": "NP_446179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446179", "type": "external" } ], "gene_names_uniprotkb": "Nfil3", "gene_names_refseq": "E4BP4; Nfil3", "protein_names_uniprotkb": "Nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4", "protein_names_refseq": "E4 promoter-binding protein 4; nuclear factor interleukin-3-regulated protein", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); severe acute respiratory syndrome (Disease Ontology:DOID:2945)", "pathway": " (rno:114519)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11262393;15306565;21635892;25536374;25993115", "class_list": "", "function": "Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP., [RefSeq, PubMed]; Pathways regulated by E4BP4 are of potential interest both for understanding neuromuscular development and for promoting neuronal survival and regeneration in pathological situations, [RefSeq, PubMed]; Removal of NFIL3 in vivo does not recapitulate the regeneration-promoting effects that were previously observed in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; Results demonstrate that NFIL3 is an important negative transcription factor, which through binding to the promoter of IGF2R, suppresses the apoptosis induced by IGF2R signaling in H9c2 cardiomyoblast cells under hypoxic conditions., [RefSeq, PubMed]; The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923M2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006955 immune response;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6IMZ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3K9-1", "uniprot_id": [ { "id": "GIMA4_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3K9", "type": "external" } ], "mass": 35823.0, "length": 310, "protein_name": "GTPase IMAP family member 4", "gene_name": "Gimap4", "organism": "Rat", "refseq_name": "GTPase IMAP family member 4", "refseq_ac": [ { "id": "NP_775176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775176", "type": "external" } ], "gene_names_uniprotkb": "Gimap4; Ian1; Imap4", "gene_names_refseq": "Gimap4; Ian1", "protein_names_uniprotkb": "GTPase IMAP family member 4; IAN-1; Immunity-associated nucleotide 1 protein; Immunity-associated protein 4", "protein_names_refseq": "GTPase IMAP family member 4; IAN-1; immune-associated nucleotide 1; immunity-associated nucleotide 1 protein; immunity-associated protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:286938)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12031988;17641045;22673903", "class_list": "", "function": "A severe deficiency of Gimap4 expression in the inbred Brown Norway (BN) rat links this trait to the Gimap gene cluster on rat chromosome 4, the probable cause being an AT dinucleotide insertion in the BN Gimap4 allele., [RefSeq, PubMed]; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K3K9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PW3-1", "uniprot_id": [ { "id": "NEUR1_RAT", "url": "https://www.uniprot.org/uniprot/Q99PW3", "type": "external" } ], "mass": 44695.0, "length": 409, "protein_name": "Sialidase-1", "gene_name": "Neu1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Neu1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sialidase-1; 3.2.1.18; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; Neuraminidase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mucolipidosis (Disease Ontology:DOID:0080488); glycoproteinosis (Disease Ontology:DOID:3343)", "pathway": " (rno:24591); (R-RNO-4085001); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11162581", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage., [UniProtKB, UniProtKB]; Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0016997 alpha-sialidase activity;GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0010976 positive regulation of neuron projection development;GO:2000291 regulation of myoblast proliferation;GO:0009313 oligosaccharide catabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99PW3-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG88-1", "uniprot_id": [ { "id": "GPSM3_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG88", "type": "external" } ], "mass": 17492.0, "length": 158, "protein_name": "G protein-signaling modulator 3", "gene_name": "Gpsm3; Notch4", "organism": "Rat", "refseq_name": "G-protein-signaling modulator 3", "refseq_ac": [ { "id": "NP_001003974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003974", "type": "external" } ], "gene_names_uniprotkb": "Gpsm3; Notch4", "gene_names_refseq": "AGS4; G18; Gpsm3; Ng1", "protein_names_uniprotkb": "G protein-signaling modulator 3", "protein_names_refseq": "G-protein signaling modulator 3 (AGS3-like, C. elegans); G-protein signalling modulator 3 (AGS3-like, C. elegans); G-protein-signaling modulator 3; activator of G-protein signalling 4", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); endometrial cancer (Disease Ontology:DOID:1380); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); hemangiopericytoma (Disease Ontology:DOID:264); systemic scleroderma (Disease Ontology:DOID:418); hemangioblastoma (Disease Ontology:DOID:5241); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:406162); (rno:406163); (R-RNO-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15060004;22673903;29393594", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system., [UniProtKB, UniProtKB]; Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030695 GTPase regulator activity;GO:0003713 transcription coactivator activity;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface", "go_biological_process": "GO:0006955 immune response;GO:0050729 positive regulation of inflammatory response;GO:0002690 positive regulation of leukocyte chemotaxis;GO:1900017 positive regulation of cytokine production involved in inflammatory response;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6MG88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6T4-1", "uniprot_id": [ { "id": "EMAL2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6T4", "type": "external" } ], "mass": 70711.0, "length": 649, "protein_name": "Echinoderm microtubule-associated protein-like 2", "gene_name": "Eml2", "organism": "Rat", "refseq_name": "echinoderm microtubule-associated protein-like 2 isoform 1", "refseq_ac": [ { "id": "NP_001401579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401579", "type": "external" } ], "gene_names_uniprotkb": "Eml2; Emap2", "gene_names_refseq": "Emap-2; Emap; Eml1; Eml2", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 2; EMAP-2", "protein_names_refseq": "echinoderm microtubule associated protein like 2; echinoderm microtubule-associated protein-like 2 isoform 1", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:192360)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11829466;21647708;33416103", "class_list": "", "function": "Changes in the expression of endothelial monocyteactivating polypeptide II in the rat hippocampus following status epilepticus., [RefSeq, PubMed]; RhoA/ROCK signaling plays a role in endothelial-monocyte-activating polypeptide (EMAP) II-induced increase in blood-tumor barrier (BTB) permeability in rat brain microvascular endothelial cells., [RefSeq, PubMed]; Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIM8", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0005874 microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0000226 microtubule cytoskeleton organization;GO:0031115 negative regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6P6T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6V1-1", "uniprot_id": [ { "id": "GLT11_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6V1", "type": "external" } ], "mass": 69039.0, "length": 608, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 11", "gene_name": "Galnt11", "organism": "Rat", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 11", "refseq_ac": [ { "id": "NP_955425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955425", "type": "external" } ], "gene_names_uniprotkb": "Galnt11", "gene_names_refseq": "Galnt11", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 11; 2.4.1.41; GalNAc-T11; Polypeptide GalNAc transferase 11; Protein-UDP acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; pp-GaNTase 11", "protein_names_refseq": ":polypeptide N-acetylgalactosaminyltransferase 11; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11); galNAc-T11; polypeptide GalNAc transferase 11; polypeptide N-acetylgalactosaminyltransferase 11; pp-GaNTase 11; protein-UDP acetylgalactosaminyltransferase 11", "tax_id": 10116, "disease": "", "pathway": " (rno:311952); (R-RNO-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "glycogene;glycosyltransferase", "function": "Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005112 Notch binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0061314 Notch signaling involved in heart development;GO:0007220 Notch receptor processing;GO:0006493 protein O-linked glycosylation;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 7434, "hit_score": 0.2, "record_id": "Q6P6V1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7C7-1", "uniprot_id": [ { "id": "GPNMB_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7C7", "type": "external" } ], "mass": 63731.0, "length": 572, "protein_name": "Transmembrane glycoprotein NMB", "gene_name": "Gpnmb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpnmb", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane glycoprotein NMB", "protein_names_refseq": "", "tax_id": 10116, "disease": "pigment dispersion syndrome (Disease Ontology:DOID:0060680); primary localized cutaneous amyloidosis 3 (Disease Ontology:DOID:0080932); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (R-RNO-8857538)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Could be a melanogenic enzyme., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 11, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048018 receptor ligand activity;GO:0045545 syndecan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0031901 early endosome membrane;GO:0033162 melanosome membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0030335 positive regulation of cell migration;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7C7-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q1P3-1", "uniprot_id": [ { "id": "KCNKI_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q1P3", "type": "external" } ], "mass": 45351.0, "length": 405, "protein_name": "Potassium channel subfamily K member 18", "gene_name": "Kcnk18", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 18 isoform 1", "refseq_ac": [ { "id": "NP_001003820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003820", "type": "external" } ], "gene_names_uniprotkb": "Kcnk18; Tresk-2; Tresk2", "gene_names_refseq": "Kcnk18; Tresk-2", "protein_names_uniprotkb": "Potassium channel subfamily K member 18; Tresk-2; Two-pore-domain potassium channel TRESK", "protein_names_refseq": "potassium channel subfamily K member 18 isoform 1; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; tandem-pore K+ (K(2P)) channel; two-pore-domain potassium channel TRESK", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273); heart disease (Disease Ontology:DOID:114); epilepsy (Disease Ontology:DOID:1826); migraine (Disease Ontology:DOID:6364)", "pathway": " (rno:445371); (R-RNO-1299344); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15123670;16192517;19716403;23904616;30327410;33256222", "class_list": "", "function": "K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:16192517). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (By similarity). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity)., [UniProtKB, PubMed, UniProtKB]; Reduction of functional TRESK channels in DRG neurons contributes to the sensitization of nociceptive sensory neurons and cancer pain development through enhancing neuronal excitability Publication Status: Online-Only, [RefSeq, PubMed]; TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells., [RefSeq, PubMed]; The endogenous TRESK currents control the onset and the frequency of action potential in small-diameter TG neurons and the frameshift mutation results in hyperexcitability of these neurons., [RefSeq, PubMed]; These results provide an anatomic basis for identifying functional roles of TRESK in the rat nervous system., [RefSeq, PubMed]; Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0046872 metal ion binding;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071467 cellular response to pH;GO:0071805 potassium ion transmembrane transport;GO:0097623 potassium ion export across plasma membrane;GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6Q1P3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TMG5-1", "uniprot_id": [ { "id": "NEMO_RAT", "url": "https://www.uniprot.org/uniprot/Q6TMG5", "type": "external" } ], "mass": 48066.0, "length": 412, "protein_name": "NF-kappa-B essential modulator", "gene_name": "Ikbkg", "organism": "Rat", "refseq_name": "NF-kappa-B essential modulator", "refseq_ac": [ { "id": "NP_954534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954534", "type": "external" } ], "gene_names_uniprotkb": "Ikbkg; Nemo", "gene_names_refseq": "Ikbkg; Nemo", "protein_names_uniprotkb": "NF-kappa-B essential modulator; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; IkB kinase subunit gamma; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NEMO; NF-kappa-B essential modifier", "protein_names_refseq": "I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; NF-kappa-B essential modifier; NF-kappa-B essential modulator; ikB kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa B kinase subunit gamma", "tax_id": 10116, "disease": "ectodermal dysplasia and immunodeficiency 1 (Disease Ontology:DOID:0081078); immunodeficiency 33 (Disease Ontology:DOID:0112003); Bloch-Sulzberger syndrome (Disease Ontology:DOID:12305); Behcet's disease (Disease Ontology:DOID:13241); liver cancer (Disease Ontology:DOID:3571); hepatocellular carcinoma (Disease Ontology:DOID:684); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); learning disability (Disease Ontology:DOID:8927); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:309295); (R-RNO-1169091); (R-RNO-168638); (R-RNO-1810476); (R-RNO-202424); (R-RNO-2871837); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-4755510); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5607764); (R-RNO-5684264); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-9020702); (R-RNO-933542); (R-RNO-937039); (R-RNO-937041); (R-RNO-975144); (R-RNO-9758274); (R-RNO-9833482); (R-RNO-9860276); (R-RNO-9860927); (R-RNO-9909505)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "12968033;37683611", "class_list": "", "function": "Damaged mitochondria recruit the effector NEMO to activate NF-kappaB signaling., [RefSeq, PubMed]; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TMG5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VBQ8-1", "uniprot_id": [ { "id": "PNO1_RAT", "url": "https://www.uniprot.org/uniprot/Q6VBQ8", "type": "external" } ], "mass": 27472.0, "length": 248, "protein_name": "RNA-binding protein PNO1", "gene_name": "Pno1", "organism": "Rat", "refseq_name": "RNA-binding protein PNO1", "refseq_ac": [ { "id": "NP_954514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954514", "type": "external" } ], "gene_names_uniprotkb": "Pno1", "gene_names_refseq": "Pno1", "protein_names_uniprotkb": "RNA-binding protein PNO1", "protein_names_refseq": "RNA-binding protein PNO1; putatative 28 kDa protein", "tax_id": 10116, "disease": "", "pathway": " (rno:289809); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15497447", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6VBQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X9T8-1", "uniprot_id": [ { "id": "HCST_RAT", "url": "https://www.uniprot.org/uniprot/Q6X9T8", "type": "external" } ], "mass": 8205.0, "length": 79, "protein_name": "Hematopoietic cell signal transducer", "gene_name": "Hcst", "organism": "Rat", "refseq_name": "hematopoietic cell signal transducer precursor", "refseq_ac": [ { "id": "NP_001005900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005900", "type": "external" } ], "gene_names_uniprotkb": "Hcst; Dap10", "gene_names_refseq": "Dap10; Hcst", "protein_names_uniprotkb": "Hematopoietic cell signal transducer; DNAX-activation protein 10; Membrane protein DAP10", "protein_names_refseq": "DNAX-activation protein 10; hematopoietic cell signal transducer precursor; membrane protein DAP10", "tax_id": 10116, "disease": "", "pathway": " (rno:474146); (R-RNO-198933)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22084441", "class_list": "", "function": "Both adaptor proteins DAP12 and DAP10 can associate with rat CD94/NKG2C; rat CD94 coimmunoprecipitates with both DAP12 and DAP10., [RefSeq, PubMed]; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as a docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full KLRK1-HCST-mediated activation and ultimate killing of target cells. In NK cells, KLRK1-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. KLRK1-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express KLRK1 ligands escape from immune surveillance mediated by NK cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050776 regulation of immune response;GO:0042267 natural killer cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6X9T8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XVN8-1", "uniprot_id": [ { "id": "MLP3A_RAT", "url": "https://www.uniprot.org/uniprot/Q6XVN8", "type": "external" } ], "mass": 14272.0, "length": 121, "protein_name": "Microtubule-associated protein 1 light chain 3 alpha", "gene_name": "Map1lc3a", "organism": "Rat", "refseq_name": "microtubule-associated protein 1 light chain 3 alpha", "refseq_ac": [ { "id": "NP_955794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955794", "type": "external" } ], "gene_names_uniprotkb": "Map1lc3a", "gene_names_refseq": "LC3-II; LC3-I; LC3A; Map1lc3a", "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 alpha; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; Microtubule-associated proteins 1A/1B light chain 3A", "protein_names_refseq": "MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated protein 1 light chain 3 alpha; microtubule-associated proteins 1A/1B light chain 3A", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); glioblastoma (Disease Ontology:DOID:3068); ischemia (Disease Ontology:DOID:326); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:362245); (R-RNO-1632852); (R-RNO-5205685); (R-RNO-8934903)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "16874114;22421968;29934347;33236922;33673233", "class_list": "", "function": "Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress., [RefSeq, PubMed]; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0010288 response to lead ion;GO:0007254 JNK cascade;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6XVN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q70VB1-1", "uniprot_id": [ { "id": "GPC6A_RAT", "url": "https://www.uniprot.org/uniprot/Q70VB1", "type": "external" } ], "mass": 104353.0, "length": 928, "protein_name": "G protein-coupled receptor family C group 6 member A", "gene_name": "Gprc6a", "organism": "Rat", "refseq_name": "G-protein coupled receptor family C group 6 member A precursor", "refseq_ac": [ { "id": "NP_001258035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258035", "type": "external" } ], "gene_names_uniprotkb": "Gprc6a", "gene_names_refseq": "Gprc6a", "protein_names_uniprotkb": "G protein-coupled receptor family C group 6 member A", "protein_names_refseq": "G-protein coupled receptor family C group 6 member A precursor; G-protein coupled receptor family C group 6 member A", "tax_id": 10116, "disease": "", "pathway": " (rno:294394); (R-RNO-416476); (R-RNO-420499)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17478059;28280242;29393594", "class_list": "", "function": "Cloning and characterization of rat GPRC6A, [RefSeq, PubMed]; GPRC6A predominantly undergoes constitutive internalization with the early endosome marker Rab5 and the long loop recycling endosome marker Rab11 and to a much lesser extent with the late endosome marker Rab7, [RefSeq, PubMed]; Receptor activated by multiple ligands, including osteocalcin (BGLAP), basic amino acids, and various cations (By similarity). Activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids (PubMed:17478059). The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+) (By similarity). Seems to act through a G(q)/G(11) and G(i)-coupled pathway (By similarity). Regulates testosterone production by acting as a ligand for uncarboxylated osteocalcin hormone: osteocalcin-binding at the surface of Leydig cells initiates a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (By similarity). Mediates the non-genomic effects of androgens in multiple tissue (By similarity). May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q70VB1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q711G3-1", "uniprot_id": [ { "id": "IAH1_RAT", "url": "https://www.uniprot.org/uniprot/Q711G3", "type": "external" } ], "mass": 28004.0, "length": 249, "protein_name": "Isoamyl acetate-hydrolyzing esterase 1 homolog", "gene_name": "Iah1", "organism": "Rat", "refseq_name": "isoamyl acetate-hydrolyzing esterase 1 homolog", "refseq_ac": [ { "id": "NP_001094010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094010", "type": "external" } ], "gene_names_uniprotkb": "Iah1; Harpb64", "gene_names_refseq": "Harpb64; Iah1", "protein_names_uniprotkb": "Isoamyl acetate-hydrolyzing esterase 1 homolog; 3.1.-.-; Hypertrophic agonist-responsive protein B64", "protein_names_refseq": "hypertrophic agonist-responsive protein B64; isoamyl acetate-hydrolyzing esterase 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298917)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable lipase., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q711G3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71UE8-1", "uniprot_id": [ { "id": "NEDD8_RAT", "url": "https://www.uniprot.org/uniprot/Q71UE8", "type": "external" } ], "mass": 8972.0, "length": 81, "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "Nedd8", "organism": "Rat", "refseq_name": "ubiquitin-like protein NEDD8", "refseq_ac": [ { "id": "NP_620233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620233", "type": "external" } ], "gene_names_uniprotkb": "Nedd8", "gene_names_refseq": "CDK8; Nedd8", "protein_names_uniprotkb": "Ubiquitin-like protein NEDD8; Neddylin", "protein_names_refseq": "neddylin; neural precursor cell expressed, developmentally down-regulated 8; neural precursor cell expressed, developmentally down-regulated gene 8; ubiquitin-like protein NEDD8", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Parkinson's disease (Disease Ontology:DOID:14330); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (rno:25490); (R-RNO-2173789); (R-RNO-5689603); (R-RNO-8856825); (R-RNO-8951664); (R-RNO-917937)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "21808025", "class_list": "", "function": "Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Neddylates EGFR resulting in protein stabilization and translocation to the cell membrane (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030162 regulation of proteolysis;GO:0008104 intracellular protein localization;GO:0072757 cellular response to camptothecin;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q71UE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76HM9-1", "uniprot_id": [ { "id": "HYAL3_RAT", "url": "https://www.uniprot.org/uniprot/Q76HM9", "type": "external" } ], "mass": 46207.0, "length": 412, "protein_name": "Hyaluronidase-3", "gene_name": "Hyal3", "organism": "Rat", "refseq_name": "hyaluronidase-3 precursor", "refseq_ac": [ { "id": "NP_997482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997482", "type": "external" } ], "gene_names_uniprotkb": "Hyal3", "gene_names_refseq": "Hyal3", "protein_names_uniprotkb": "Hyaluronidase-3; 3.2.1.35; Hyal-3; Hyaluronoglucosaminidase-3", "protein_names_refseq": "hyal-3; hyaluronidase-3 precursor; hyaluronoglucosaminidase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:300993); (R-RNO-2024101); (R-RNO-2160916)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8Q0", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity;GO:0033906 hyaluronoglucuronidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:2000355 negative regulation of ovarian follicle development;GO:0006954 inflammatory response;GO:0005975 carbohydrate metabolic process;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q76HM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76IC5-1", "uniprot_id": [ { "id": "PGPI_RAT", "url": "https://www.uniprot.org/uniprot/Q76IC5", "type": "external" } ], "mass": 22913.0, "length": 209, "protein_name": "Pyroglutamyl-peptidase 1", "gene_name": "Mk1; Pgpep1", "organism": "Rat", "refseq_name": "pyroglutamyl-peptidase 1", "refseq_ac": [ { "id": "NP_973717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_973717", "type": "external" } ], "gene_names_uniprotkb": "Mk1; Pgpep1; Pgpep1", "gene_names_refseq": "PAPI; Pgpep1", "protein_names_uniprotkb": "Pyroglutamyl-peptidase 1; 3.4.19.3; 5-oxoprolyl-peptidase; PAP-I; PGP-I; Pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase", "protein_names_refseq": "5-oxoprolyl-peptidase; PAP-I; PGP-I; pyroglutamyl aminopeptidase I; pyroglutamyl-peptidase 1; pyrrolidone-carboxylate peptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:290648)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12450739;12953169;14600395;21329657", "class_list": "", "function": "PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress., [RefSeq, PubMed]; Pyroglutamyl aminopeptidase Type-1 shows differentiated activity in various parts of the brain under varied conditions of hydration in rats., [RefSeq, PubMed]; Removes 5-oxoproline from various penultimate amino acid residues except L-proline., [UniProtKB, PubMed]; Significant correlation between Pcp activity and the number and size of tumours and the body weight of the animals. Decreased Pcp may reflect increase in circulating GnRH leading to increase in gonadal steroid hormones., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008233 peptidase activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0032233 positive regulation of actin filament bundle assembly;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76IC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78ZR5-1", "uniprot_id": [ { "id": "HOP_RAT", "url": "https://www.uniprot.org/uniprot/Q78ZR5", "type": "external" } ], "mass": 8282.0, "length": 73, "protein_name": "Homeodomain-only protein", "gene_name": "Hopx", "organism": "Rat", "refseq_name": "homeodomain-only protein", "refseq_ac": [ { "id": "NP_598305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598305", "type": "external" } ], "gene_names_uniprotkb": "Hopx; Giig15b; Hod; Hop; Ob1", "gene_names_refseq": "GIIg15b; Hod; Hopx; Obl", "protein_names_uniprotkb": "Homeodomain-only protein; GIIg15b; Global ischemia-induced gene 15B protein; Odd homeobox protein 1", "protein_names_refseq": "global ischemia induced protein GIIG15B; global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; homeobox only domain; homeodomain-only protein; odd homeobox 1; odd homeobox protein 1", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:171160)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12297046;14516659;22673903;34943964", "class_list": "", "function": "Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding., [UniProtKB, UniProtKB, UniProtKB]; HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R4G4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0035033 histone deacetylase regulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0048286 lung alveolus development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q78ZR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M733-1", "uniprot_id": [ { "id": "HPS6_RAT", "url": "https://www.uniprot.org/uniprot/Q7M733", "type": "external" } ], "mass": 87463.0, "length": 809, "protein_name": "BLOC-2 complex member HPS6", "gene_name": "Hps6", "organism": "Rat", "refseq_name": "BLOC-2 complex member HPS6", "refseq_ac": [ { "id": "NP_852097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852097", "type": "external" } ], "gene_names_uniprotkb": "Hps6", "gene_names_refseq": "Hps6; Hsp6", "protein_names_uniprotkb": "BLOC-2 complex member HPS6; Hermansky-Pudlak syndrome 6 protein homolog; Ruby-eye protein homolog; Ruby-eye-like protein; Ru", "protein_names_refseq": "BLOC-2 complex member HPS6; hermansky-Pudlak syndrome 6 protein homolog; ruby-eye protein homolog; ruby-eye-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:309446)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12548288;19010779;29393594", "class_list": "", "function": "May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0031084 BLOC-2 complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0055088 lipid homeostasis;GO:0007596 blood coagulation;GO:0072657 protein localization to membrane;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7M733-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNI4-1", "uniprot_id": [ { "id": "I22R2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNI4", "type": "external" } ], "mass": 26722.0, "length": 229, "protein_name": "Interleukin-22 receptor subunit alpha-2", "gene_name": "Il22ra2", "organism": "Rat", "refseq_name": "interleukin-22 receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_001003404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003404", "type": "external" } ], "gene_names_uniprotkb": "Il22ra2", "gene_names_refseq": "Crf2-s1; Il22ra2", "protein_names_uniprotkb": "Interleukin-22 receptor subunit alpha-2; CRF2-S1; Cytokine receptor family type 2, soluble 1; IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22BP; Interleukin-22-binding protein", "protein_names_refseq": "IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; IL-22RA2; IL22BP; cytokine receptor family II soluble 1; cytokine receptor family type 2, soluble 1; interleukin 22 receptor, alpha 2; interleukin-22 receptor subunit alpha-2 precursor; interleukin-22-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:444986); (R-RNO-8854691)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15201862;21041731;26329427;28356382;31292217", "class_list": "", "function": "IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis., [RefSeq, PubMed]; Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization, [RefSeq, PubMed]; Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses., [UniProtKB, UniProtKB, UniProtKB]; This study shows that rats with genetic IL-22BP deficiency (Il22ra2-/-) display exacerbated psoriasis that is associated with enhanced expression of IL-22-inducible antimicrobial peptides, [RefSeq, PubMed]; Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042017 interleukin-22 binding;GO:0042018 interleukin-22 receptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0140368 decoy receptor complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway;GO:0042509 regulation of tyrosine phosphorylation of STAT protein", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7TNI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNJ7-1", "uniprot_id": [ { "id": "KCC1G_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNJ7", "type": "external" } ], "mass": 53179.0, "length": 476, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1G", "gene_name": "Camk1g", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1G isoform 1", "refseq_ac": [ { "id": "NP_878262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878262", "type": "external" } ], "gene_names_uniprotkb": "Camk1g; Camkig", "gene_names_refseq": "Camk1g", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1G; 2.7.11.17; CLICK III; CaM kinase I gamma; CaM kinase IG; CaM-KI gamma; CaMK-like CREB kinase III; CaMKI gamma; CaMKIG", "protein_names_refseq": "CLICK III; caM kinase I gamma; caM kinase IG; caM-KI gamma; caMK-like CREB kinase III; caMKI gamma; caMKIG; calcium/calmodulin-dependent protein kinase I gamma; calcium/calmodulin-dependent protein kinase type 1G isoform 1; calcium/calmodulin-dependent protein kinase type 1G", "tax_id": 10116, "disease": "", "pathway": " (rno:171358)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12753081;19657032;9074610", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity)., [UniProtKB]; Findings suggest that both alternatively splicing isoforms of CaMKI gamma may be involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal population, [RefSeq, PubMed]; These results are consistent with a model in which highly localized calcium influx through the TRPC5 channels activates CaMKK and CaMKI, which subsequently promote axon formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08763;Q7TNJ6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005954 calcium- and calmodulin-dependent protein kinase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T02-1", "uniprot_id": [ { "id": "GPBAR_RAT", "url": "https://www.uniprot.org/uniprot/Q80T02", "type": "external" } ], "mass": 35791.0, "length": 329, "protein_name": "G protein-coupled bile acid receptor 1", "gene_name": "Gpbar1", "organism": "Rat", "refseq_name": "G-protein coupled bile acid receptor 1", "refseq_ac": [ { "id": "NP_808797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808797", "type": "external" } ], "gene_names_uniprotkb": "Gpbar1; Tgr5", "gene_names_refseq": "Gpbar1; M-BAR; Tgr5", "protein_names_uniprotkb": "G protein-coupled bile acid receptor 1; M-BAR; Membrane-type receptor for bile acids", "protein_names_refseq": "G protein-coupled receptor; G-protein coupled bile acid receptor 1; membrane-type receptor for bile acids", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:338443); (R-RNO-373076)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12419312;12524422;17326144;18468513;33055426;33427060;33531049;38329942;39082696", "class_list": "", "function": "Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury., [RefSeq, PubMed]; Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding. Publication Status: Online-Only, [RefSeq, PubMed]; Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5., [RefSeq, PubMed]; G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (By similarity). Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation (By similarity). GPBAR1-mediated signaling promotes energy expenditure and adiposity reduction in brown adipose tissue by activating adenylate cyclase, leading to DIO2 activation. Involved in bile acid promoted GLP-1 secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. Publication Status: Online-Only, [RefSeq, PubMed]; TGR5 is implicated in the suppression of macrophage functions by bile acids, [RefSeq, PubMed]; TGR5 is localized in the plasma membrane of isolated Kupffer cells and is responsive to bile acids;it may play a protective role in obstructive cholestasis preventing excessive cytokine production thereby reducing liver injury., [RefSeq, PubMed]; The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome., [RefSeq, PubMed]; This is the first report on the expression of TGR5 in sinusoidal endothelial cells. Regulation of eNOS by TGR5 connects bile salts with hepatic hemodynamics., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038182 G protein-coupled bile acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0097009 energy homeostasis;GO:1904056 positive regulation of cholangiocyte proliferation;GO:2000810 regulation of bicellular tight junction assembly;GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q80T02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80UA9-1", "uniprot_id": [ { "id": "INSI2_RAT", "url": "https://www.uniprot.org/uniprot/Q80UA9", "type": "external" } ], "mass": 24968.0, "length": 225, "protein_name": "Insulin-induced gene 2 protein", "gene_name": "Insig2", "organism": "Rat", "refseq_name": "insulin-induced gene 2 protein isoform 1", "refseq_ac": [ { "id": "NP_835192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835192", "type": "external" } ], "gene_names_uniprotkb": "Insig2", "gene_names_refseq": "Insig2", "protein_names_uniprotkb": "Insulin-induced gene 2 protein; INSIG-2", "protein_names_refseq": "INSIG-2; insulin-induced gene 2 protein isoform 1; insulin-induced gene 2 protein; involved in retention of the SCAP/SREBP complex in the endoplasmic reticulum", "tax_id": 10116, "disease": "end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:288985)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12624180;26007286", "class_list": "", "function": "Data suggest expression of hepatocyte Insig1/Insig2a and Crebh/Creb3l3 (cAMP responsive element-binding protein 3-like 3 protein) can be up-regulated by dietary factors (here, dietary supplementation with hypotriglyceridemic R-alpha-lipoic acid)., [RefSeq, PubMed]; Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis., [RefSeq, PubMed]; Mediates feedback control of cholesterol synthesis., [UniProtKB, UniProtKB]; Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0032937 SREBP-SCAP-Insig complex", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0008203 cholesterol metabolic process;GO:0032869 cellular response to insulin stimulus;GO:0042472 inner ear morphogenesis;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80UA9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80V38-1", "uniprot_id": [ { "id": "HPIP_RAT", "url": "https://www.uniprot.org/uniprot/Q80V38", "type": "external" } ], "mass": 12991.0, "length": 116, "protein_name": "Host cell factor C1 regulator 1", "gene_name": "Hcfc1r1", "organism": "Rat", "refseq_name": "host cell factor C1 regulator 1", "refseq_ac": [ { "id": "NP_001093962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093962", "type": "external" } ], "gene_names_uniprotkb": "Hcfc1r1; Hpip", "gene_names_refseq": "Hcfc1r1; Hpip", "protein_names_uniprotkb": "Host cell factor C1 regulator 1; HCF-1 beta-propeller-interacting protein; Inhibitor of four 2", "protein_names_refseq": "HCF-1 beta-propeller-interacting protein; host cell factor C1 regulator 1 (XPO1-dependent); host cell factor C1 regulator 1; inhibitor of four 2", "tax_id": 10116, "disease": "", "pathway": " (rno:287097)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80V38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W66-1", "uniprot_id": [ { "id": "HS3S2_RAT", "url": "https://www.uniprot.org/uniprot/Q80W66", "type": "external" } ], "mass": 41378.0, "length": 367, "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 2", "gene_name": "Hs3st2", "organism": "Rat", "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 2", "refseq_ac": [ { "id": "NP_852035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852035", "type": "external" } ], "gene_names_uniprotkb": "Hs3st2; 3ost2", "gene_names_refseq": "Hs3st2", "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 2; 2.8.2.29; Heparan sulfate 3-O-sulfotransferase 2; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2", "protein_names_refseq": "heparan sulfate (glucosamine) 3-O-sulfotransferase 2; heparan sulfate 3-O-sulfotransferase 2; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2; heparan sulfate glucosamine 3-O-sulfotransferase 2", "tax_id": 10116, "disease": "lung cancer (Disease Ontology:DOID:1324); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:293451); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12601002;14630922", "class_list": "", "function": "3-O sulfation catalyzed by HS 3-O-sulfotransferase (3-OST2) is predominantly restricted to daytime pineal glands in rats, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). May contribute to the pineal circadian physiology (PubMed:12601002)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A1A5M1", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.29", "type": "external" }, { "id": "2.8.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.23", "type": "external" } ], "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity;GO:0008146 sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z34-1", "uniprot_id": [ { "id": "NREP_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z34", "type": "external" } ], "mass": 7648.0, "length": 68, "protein_name": "Neuronal regeneration-related protein", "gene_name": "Nrep", "organism": "Rat", "refseq_name": "neuronal regeneration-related protein", "refseq_ac": [ { "id": "NP_001406489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406489", "type": "external" } ], "gene_names_uniprotkb": "Nrep; P311", "gene_names_refseq": "Nrep; P311", "protein_names_uniprotkb": "Neuronal regeneration-related protein; Neuronal protein 3.1; Protein p311", "protein_names_refseq": "neuronal protein 3.1; neuronal regeneration-related protein; protein p311", "tax_id": 10116, "disease": "", "pathway": " (rno:338475)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15485502;26335191;26559022;29436600;35779227", "class_list": "", "function": "Efficiently blocked Smad-ILK pathway activation and attenuated epithelial-mesenchymal transition induced by TGF-beta1, [RefSeq, PubMed]; Identified a gene, previously designated P311, up-regulated in axotomized facial motoneurons; ectopically expressed P311 localizes in the cytoplasm and the nucleus; over-expression of P311 induces p21(WAF1/Cip1), leading PC12 cells to differentiate [P311], [RefSeq, PubMed]; May have roles in neural function. Ectopic expression promotes axonal regeneration. Also augments motility of gliomas (By similarity). May also have roles in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration (By similarity). Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation (By similarity)., [UniProtKB, PubMed]; P311 gene, together with alpha-SMA and TGF-beta1 genes, was induced in the process of Tubular epithelial-myofibroblast transition (TEMT) in rat., [RefSeq, PubMed]; P311 knockdown alleviates hyperoxia-induced injury by inactivating the Smad3 signaling pathway in type II alveolar epithelial cells., [RefSeq, PubMed]; P311 may be involved in the pathogenesis of renal fibrosis by blocking TGF-beta1-mediated epithelial-mesenchymal transition via TGF-beta1-Smad-ILK pathway in unilateral ureteral occlusion kidneys., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0045664 regulation of neuron differentiation;GO:0031103 axon regeneration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80Z34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZC8-1", "uniprot_id": [ { "id": "KLRE1_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZC8", "type": "external" } ], "mass": 26266.0, "length": 226, "protein_name": "Killer cell lectin-like receptor subfamily E member 1", "gene_name": "Klre1", "organism": "Rat", "refseq_name": "killer cell lectin-like receptor subfamily E member 1 isoform 1", "refseq_ac": [ { "id": "NP_852037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852037", "type": "external" } ], "gene_names_uniprotkb": "Klre1", "gene_names_refseq": "Klre1", "protein_names_uniprotkb": "Killer cell lectin-like receptor subfamily E member 1", "protein_names_refseq": "NK cell lectin-like receptor family E, member 1; killer cell lectin-like receptor subfamily E member 1 isoform 1; killer cell lectin-like receptor, family E, member 1; killer cell lectin-like receptor, subfamily E, member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297645)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12782717;18713988", "class_list": "", "function": "Cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1, [RefSeq, PubMed]; KLRE-KLRI1 heterodimer is a functional inhibitory heterodimer in NK cells; KLRE1-KLRI2 heterodimer is a functional activating heterodimer in NK cells, [RefSeq, PubMed]; Lectin-like receptor for natural killer (NK) cells (PubMed:12782717, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80ST4", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0019903 protein phosphatase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002228 natural killer cell mediated immunity;GO:0034260 negative regulation of GTPase activity;GO:0045954 positive regulation of natural killer cell mediated cytotoxicity;GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0002223 stimulatory C-type lectin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80ZC8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1M5-1", "uniprot_id": [ { "id": "NPW_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1M5", "type": "external" } ], "mass": 20231.0, "length": 185, "protein_name": "Neuropeptide W", "gene_name": "Npw", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Npw; Ppl8", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropeptide W; L8C; L8; PPL8; Preproprotein L8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:259224); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12130646;12810535", "class_list": "", "function": "Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K1M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1Q0-1", "uniprot_id": [ { "id": "NMT1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1Q0", "type": "external" } ], "mass": 56860.0, "length": 496, "protein_name": "Glycylpeptide N-tetradecanoyltransferase 1", "gene_name": "Nmt1", "organism": "Rat", "refseq_name": "glycylpeptide N-tetradecanoyltransferase 1", "refseq_ac": [ { "id": "NP_683689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683689", "type": "external" } ], "gene_names_uniprotkb": "Nmt1", "gene_names_refseq": "Nmt1", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase 1; 2.3.1.97; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Peptide N-myristoyltransferase 1; Type I N-myristoyltransferase", "protein_names_refseq": "NMT 1; glycylpeptide N-tetradecanoyltransferase 1; myristoyl-CoA:protein N-myristoyltransferase 1; peptide N-myristoyltransferase 1; type I N-myristoyltransferase", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000)", "pathway": " (rno:259274); (R-RNO-2514859); (R-RNO-75108)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "12210757;16538398;18021392;19916857;22673903", "class_list": "", "function": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle., [UniProtKB, UniProtKB]; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins., [UniProtKB, UniProtKB]; Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion., [RefSeq, PubMed]; Cell-specific increase expression of myristoyltransferase and calcineurin in lung epithelium and endothelium, [RefSeq, PubMed]; N-myristoyltransferase may have a role in progression of colonic neoplasms Publication Status: Online-Only, [RefSeq, PubMed]; NMT1 protein exhibited functional myristoyltransferase activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" } ], "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0019107 myristoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0018008 N-terminal peptidyl-glycine N-myristoylation;GO:0001701 in utero embryonic development;GO:0072657 protein localization to membrane;GO:0006499 N-terminal protein myristoylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K1Q0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3L6-1", "uniprot_id": [ { "id": "GIMA5_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3L6", "type": "external" } ], "mass": 37266.0, "length": 326, "protein_name": "GTPase IMAP family member 5", "gene_name": "Gimap5", "organism": "Rat", "refseq_name": "GTPase IMAP family member 5 isoform 1", "refseq_ac": [ { "id": "NP_001029085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029085", "type": "external" } ], "gene_names_uniprotkb": "Gimap5; Ian4l1; Ian4; Iddm1; Lyp", "gene_names_refseq": "Gimap5; IAN4; Ian4l1; Ian5; lyp", "protein_names_uniprotkb": "GTPase IMAP family member 5; IAN-4; Immunity-associated nucleotide 4 protein; Immunity-associated nucleotide 4-like 1 protein", "protein_names_refseq": "GTPase IMAP family member 5 isoform 1; IAN-4; immune associated nucleotide 4 like 1; immunity-associated nucleotide 4 protein; immunity-associated nucleotide 4-like 1 protein; lymphopenia", "tax_id": 10116, "disease": "portal hypertension (Disease Ontology:DOID:10762); lymphopenia (Disease Ontology:DOID:614); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:246774)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12031988;12930893;15307172;15474297;21487483;21925515;23098229;26740263;27023180;28223986", "class_list": "", "function": "Data indicate that reduced Ca2+ influx in GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5)-deficient T-cells is associated with the inability of their mitochondria to sequester Ca2+ following capacitative entry., [RefSeq, PubMed]; Functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (By similarity). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). Promotes the survival of quiescent T-cells (PubMed:15307172). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (PubMed:28223986). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence., [UniProtKB, PubMed, PubMed]; Results suggest that lack of the Gimap5 protein in the DR.(lyp/lyp) congenic rat was associated with impaired expression of the entire family of Gimap genes and may regulate T cell homeostasis in the peripheral lymphoid organs., [RefSeq, PubMed]; These findings confirm a critical albeit differential role of T-cell lymphopenia in the susceptibility to organ-specific autoimmune responses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5YEJ2;Q5YEJ3;Q8K3L7", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005765 lysosomal membrane;GO:0032585 multivesicular body membrane", "go_biological_process": "GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0001659 temperature homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0032689 negative regulation of type II interferon production", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8K3L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3X8-1", "uniprot_id": [ { "id": "HSBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3X8", "type": "external" } ], "mass": 8585.0, "length": 76, "protein_name": "Heat shock factor-binding protein 1", "gene_name": "Hsbp1", "organism": "Rat", "refseq_name": "heat shock factor-binding protein 1", "refseq_ac": [ { "id": "NP_775142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775142", "type": "external" } ], "gene_names_uniprotkb": "Hsbp1", "gene_names_refseq": "Hsbp1; Hsp25", "protein_names_uniprotkb": "Heat shock factor-binding protein 1", "protein_names_refseq": "heat shock factor-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:286899); (R-RNO-3371568); (R-RNO-3371571)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18156166;18583709;36321738", "class_list": "", "function": "After diabetes, Protein kinase D control of LPL requires dissociation of Hsp25 from PKCdelta, association between PKCdelta and PKD, and vesicle fission., [RefSeq, PubMed]; HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression., [RefSeq, PubMed]; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The effect of spinal cord transection on HSP25 is muscle specific and time dependent., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0035987 endodermal cell differentiation;GO:0019896 axonal transport of mitochondrion;GO:0070370 cellular heat acclimation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K3X8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K430-1", "uniprot_id": [ { "id": "KLH17_RAT", "url": "https://www.uniprot.org/uniprot/Q8K430", "type": "external" } ], "mass": 69732.0, "length": 640, "protein_name": "Kelch-like protein 17", "gene_name": "Klhl17", "organism": "Rat", "refseq_name": "kelch-like protein 17", "refseq_ac": [ { "id": "NP_663704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663704", "type": "external" } ], "gene_names_uniprotkb": "Klhl17", "gene_names_refseq": "Klhl17", "protein_names_uniprotkb": "Kelch-like protein 17; Actinfilin", "protein_names_refseq": "actinfilin; kelch-like 17; kelch-like protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:246757)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12063253;16054660;17062563", "class_list": "", "function": "A brain specific Kelch protein, which interacts with F-actin, [RefSeq, PubMed]; Actinfilin acts as a scaffold, linking kainate-type glutamate receptor subunit GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation., [RefSeq, PubMed]; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0051015 actin filament binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0043025 neuronal cell body", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140252 regulation protein catabolic process at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K430-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4P2-1", "uniprot_id": [ { "id": "NPB_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4P2", "type": "external" } ], "mass": 13019.0, "length": 119, "protein_name": "Neuropeptide B", "gene_name": "Npb", "organism": "Rat", "refseq_name": "neuropeptide B precursor", "refseq_ac": [ { "id": "NP_695205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695205", "type": "external" } ], "gene_names_uniprotkb": "Npb", "gene_names_refseq": "Npb", "protein_names_uniprotkb": "Neuropeptide B; L7C; Preproprotein L7; rPPL7", "protein_names_refseq": "neuropeptide B precursor; preproneuropeptide B; preproprotein L7; rPPL7", "tax_id": 10116, "disease": "", "pathway": " (rno:259222); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12118011;16736466;17067739;19885618;22484289;29393594;33105700", "class_list": "", "function": "Demonstrates the expression patterns of GPR7, NPB, and NPW precursor messenger ribonucleic acid (mRNA) in the rat brain by using in situ hybridization and in situ binding experiments, [RefSeq, PubMed]; Identification of NPB, NPW and Their Receptor in the Rat Heart. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity)., [UniProtKB]; NPB-immunoreactivity was enriched in many regions within the hypothalamus which also contained high levels of GPR7 mRNA., [RefSeq, PubMed]; Neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7., [RefSeq, PubMed]; RT-PCR technique revealed the presence of NPB mRNA, NPW mRNA, and NPBWR1 mRNA, but not similar to NPBWR2 mRNA in ROB cells., [RefSeq, PubMed]; The Neuropeptide B can affect glucose and lipid homeostasis, and food intake in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4P2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K585-1", "uniprot_id": [ { "id": "HMGA1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K585", "type": "external" } ], "mass": 11706.0, "length": 107, "protein_name": "High mobility group protein HMG-I/HMG-Y", "gene_name": "Hmga1", "organism": "Rat", "refseq_name": "high mobility group protein HMG-I/HMG-Y", "refseq_ac": [ { "id": "NP_001399088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001399088", "type": "external" } ], "gene_names_uniprotkb": "Hmga1", "gene_names_refseq": "Hmga1; Hmgiy; Hmgi", "protein_names_uniprotkb": "High mobility group protein HMG-I/HMG-Y; HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1", "protein_names_refseq": "HMG-I(Y); high mobility group AT-hook protein 1; high mobility group protein A1; high mobility group protein HMG-I/HMG-Y", "tax_id": 10116, "disease": "lymphoma (Disease Ontology:DOID:0060058); uterine cancer (Disease Ontology:DOID:363); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:117062); (R-RNO-2559584)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12082527;12653562;22673903;29393594;29634420;30414623;30652345;30720182;35216347", "class_list": "", "function": "HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells. Publication Status: Online-Only, [RefSeq, PubMed]; High glucose increased HMGA1 expression and promoted proliferation of VSMCs, which could be blunted by Wortmannin and LY294002, inhibitors of PI3K/Akt pathway, and specificity protein 1 (SP1) siRNA. Moreover, knockdown of HMGA1 could weaken the upregulation of cyclin D1 accompanied by high-glucose-induced HMGA1 in VSMCs., [RefSeq, PubMed]; MiR-196a expression in brain was significantly increased in rat cerebral ischemic injury model (middle cerebral artery occlusion) and in cultured neonatal rat cortical neurons after oxygen-glucose deprivation (OGD). HMGA1 was identified as the target gene of miR-196a. miR-196a overexpression promoted OGD-induced cortical neurons apoptosis possibly through negative regulation of HMGA1., [RefSeq, PubMed]; MicroRNA-26a-5p affects myocardial injury induced by coronary microembolization by modulating HMGA1., [RefSeq, PubMed]; The findings of this study suggest that induction of Hmga1 may be important for theca and granulosa cell differentiation into luteal cells., [RefSeq, PubMed]; Thyroid cell transformation requires the expression of the HMGA1 proteins, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K1F5", "ec_number_list": [], "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0031965 nuclear membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0030878 thyroid gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003016 respiratory system process;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8K585-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H1-1", "uniprot_id": [ { "id": "IKBL1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H1", "type": "external" } ], "mass": 43293.0, "length": 381, "protein_name": "NF-kappa-B inhibitor-like protein 1", "gene_name": "Nfkbil1", "organism": "Rat", "refseq_name": "NF-kappa-B inhibitor-like protein 1", "refseq_ac": [ { "id": "NP_997674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997674", "type": "external" } ], "gene_names_uniprotkb": "Nfkbil1; Ikbl", "gene_names_refseq": "IkBL; Nfkbil1", "protein_names_uniprotkb": "NF-kappa-B inhibitor-like protein 1; I-kappa-B-like protein; IkappaBL; Inhibitor of kappa B-like protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1", "protein_names_refseq": "I-kappa-B-like protein; NF-kappa-B inhibitor-like protein 1; ikappaBL; inhibitor of kappa B-like protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1; putative inhibitor of Rel family transcription factors", "tax_id": 10116, "disease": "rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:361794)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11904681;15060004", "class_list": "", "function": "Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499T4", "ec_number_list": [], "go_molecular_function": "GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0034122 negative regulation of toll-like receptor signaling pathway;GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2H1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5I0-1", "uniprot_id": [ { "id": "KCNKF_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5I0", "type": "external" } ], "mass": 35652.0, "length": 318, "protein_name": "Potassium channel subfamily K member 15", "gene_name": "Kcnk15", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 15 precursor", "refseq_ac": [ { "id": "NP_570826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570826", "type": "external" } ], "gene_names_uniprotkb": "Kcnk15; Task5", "gene_names_refseq": "Kcnk15", "protein_names_uniprotkb": "Potassium channel subfamily K member 15; Acid-sensitive potassium channel protein TASK-5; TWIK-related acid-sensitive K(+) channel 5; rTASK-5", "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 5; acid-sensitive potassium channel protein TASK-5; potassium channel subfamily K member 15 precursor; potassium channel subfamily K member 15; potassium channel, subfamily K, member 15 (TASK-5); potassium channel, two pore domain subfamily K, member 15; rTASK-5", "tax_id": 10116, "disease": "", "pathway": " (rno:156873); (R-RNO-5576886)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11749039", "class_list": "", "function": "Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q920G1", "ec_number_list": [], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex;GO:0016020 membrane", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHV7-1", "uniprot_id": [ { "id": "HNRH1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHV7", "type": "external" } ], "mass": 49188.0, "length": 449, "protein_name": "Heterogeneous nuclear ribonucleoprotein H", "gene_name": "Hnrnph1", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein H", "refseq_ac": [ { "id": "NP_543172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543172", "type": "external" } ], "gene_names_uniprotkb": "Hnrnph1; Hnrph1; Hnrph", "gene_names_refseq": "Hnrnph1; Hnrph1; Hnrph; hnRNP H", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein H; Ratsg1; hnRNP H", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein H", "tax_id": 10116, "disease": "Sjogren's syndrome (Disease Ontology:DOID:12894); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:140931); (R-RNO-6803529); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "19343716;27117401", "class_list": "", "function": "HNRNPH is a splicing regulator of Trf2 pre-mRNA that prevents the expression of TRF2-S, a factor implicated in neuronal differentiation., [RefSeq, PubMed]; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1J1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0071013 catalytic step 2 spliceosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:1901653 cellular response to peptide;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHV7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VID6-1", "uniprot_id": [ { "id": "PDE11_RAT", "url": "https://www.uniprot.org/uniprot/Q8VID6", "type": "external" } ], "mass": 104571.0, "length": 935, "protein_name": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A", "gene_name": "Pde11a", "organism": "Rat", "refseq_name": "dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3", "refseq_ac": [ { "id": "NP_001120952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120952", "type": "external" } ], "gene_names_uniprotkb": "Pde11a", "gene_names_refseq": "Pde11a", "protein_names_uniprotkb": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; 3.1.4.35; 3.1.4.53; cAMP and cGMP phosphodiesterase 11A", "protein_names_refseq": "cAMP and cGMP phosphodiesterase 11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform 3; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A", "tax_id": 10116, "disease": "", "pathway": " (rno:140928); (R-RNO-418457); (R-RNO-418555)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11502204;17696499;19445908", "class_list": "", "function": "Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:11502204). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:11502204)., [UniProtKB, PubMed]; This report is the first to describe an inhibitory effect of the N-terminal region of PDE11A4 on the affinity of the catalytic domain for both substrates and inhibitors and the first to define the quaternary structure., [RefSeq, PubMed]; We here present, for the first time, the expression of PDE9A, PDE10A, and PDE11A in the trigeminovascular system; localisation indicates that they may have a role in pain pathways, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VID7;Q8VID8", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004118 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043204 perikaryon", "go_biological_process": "GO:0007165 signal transduction;GO:0010754 negative regulation of cGMP-mediated signaling;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VID6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z84-1", "uniprot_id": [ { "id": "IL23A_RAT", "url": "https://www.uniprot.org/uniprot/Q91Z84", "type": "external" } ], "mass": 21986.0, "length": 196, "protein_name": "Interleukin-23 subunit alpha", "gene_name": "Il23a", "organism": "Rat", "refseq_name": "interleukin-23 subunit alpha precursor", "refseq_ac": [ { "id": "NP_569094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569094", "type": "external" } ], "gene_names_uniprotkb": "Il23a", "gene_names_refseq": "Il23a", "protein_names_uniprotkb": "Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; IL-23p19; Interleukin-23 subunit p19", "protein_names_refseq": "IL-23 subunit alpha; IL-23-A; IL-23p19; Interleukin 23, alpha subunit p19; interleukin-23 subunit alpha precursor; interleukin-23 subunit p19", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:155140); (R-RNO-9020933)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29039526;34491653", "class_list": "", "function": "Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells., [UniProtKB, UniProtKB]; IL23 aggravated myocardial I/R injury by promoting inflammatory responses and myocardial apoptosis., [RefSeq, PubMed]; [Effect of electroacupuncture on expression of IL-23/IL-17 axis and TLR4 in infarcted tissue in rats with myocardial infarction]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045519 interleukin-23 receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070743 interleukin-23 complex;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0072536 interleukin-23 receptor complex", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0032693 negative regulation of interleukin-10 production;GO:0032740 positive regulation of interleukin-17 production;GO:0051135 positive regulation of NK T cell activation;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91Z84-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924S4-1", "uniprot_id": [ { "id": "KREM1_RAT", "url": "https://www.uniprot.org/uniprot/Q924S4", "type": "external" } ], "mass": 51869.0, "length": 473, "protein_name": "Kremen protein 1", "gene_name": "Kremen1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kremen1; Kremen", "gene_names_refseq": "", "protein_names_uniprotkb": "Kremen protein 1; Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose", "protein_names_refseq": "", "tax_id": 10116, "disease": "ectodermal dysplasia 13 (Disease Ontology:DOID:0111650)", "pathway": " (rno:114107); (R-RNO-3772470)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006915 apoptotic process;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q924S4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924U0-1", "uniprot_id": [ { "id": "LT4R2_RAT", "url": "https://www.uniprot.org/uniprot/Q924U0", "type": "external" } ], "mass": 37899.0, "length": 358, "protein_name": "Leukotriene B4 receptor 2", "gene_name": "Ltb4r2", "organism": "Rat", "refseq_name": "leukotriene B4 receptor 2", "refseq_ac": [ { "id": "NP_446092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446092", "type": "external" } ], "gene_names_uniprotkb": "Ltb4r2", "gene_names_refseq": "LTB4-R2; Ltb4r2", "protein_names_uniprotkb": "Leukotriene B4 receptor 2; LTB4 receptor JULF2; LTB4-R 2; LTB4-R2", "protein_names_refseq": "LTB4 receptor JULF2; leukotriene B4 receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:114098); (R-RNO-391906); (R-RNO-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10889186;21189570", "class_list": "", "function": "BLT1 and BLT2 were involved in synovial cell proliferation., [RefSeq, PubMed]; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0001632 leukotriene B4 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051546 keratinocyte migration;GO:0007165 signal transduction;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q924U0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924V1-1", "uniprot_id": [ { "id": "NOX4_RAT", "url": "https://www.uniprot.org/uniprot/Q924V1", "type": "external" } ], "mass": 66469.0, "length": 578, "protein_name": "NADPH oxidase 4", "gene_name": "Nox4", "organism": "Rat", "refseq_name": "NADPH oxidase 4", "refseq_ac": [ { "id": "NP_445976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445976", "type": "external" } ], "gene_names_uniprotkb": "Nox4; Kox", "gene_names_refseq": "Nox4", "protein_names_uniprotkb": "NADPH oxidase 4; 1.6.3.1; KOX-1; Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase", "protein_names_refseq": "NADPH oxidase 4; kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:85431); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11032835;11348997;12842860;14670934;15322091;16135519;16150729;37002575;37501791;37985134;37985248;38237016", "class_list": "", "function": "Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries., [RefSeq, PubMed]; Hypoxia stabilizes the H2 O2 -producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation., [RefSeq, PubMed]; Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-gamma axis., [RefSeq, PubMed]; Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm., [RefSeq, PubMed]; Maternal exercise represses Nox4 via SIRT1 to prevent vascular oxidative stress and endothelial dysfunction in SHR offspring. Publication Status: Online-Only, [RefSeq, PubMed]; NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (By similarity). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:15322091, PubMed:16135519). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (By similarity). May regulate insulin signaling cascade (By similarity). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (By similarity). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release., [UniProtKB, UniProtKB, UniProtKB]; Nox4-based NAD(P)H oxidase and generation of reactive oxygen species mediate the effect of ANG II on Akt/PKB activation and protein synthesis in glomerular mesangial cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99M78", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" } ], "go_molecular_function": "GO:0020037 heme binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:1990782 protein tyrosine kinase binding;GO:0072341 modified amino acid binding;GO:0016175 superoxide-generating NAD(P)H oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0010729 positive regulation of hydrogen peroxide biosynthetic process;GO:0006952 defense response;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q924V1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Y4-1", "uniprot_id": [ { "id": "GATA2_RAT", "url": "https://www.uniprot.org/uniprot/Q924Y4", "type": "external" } ], "mass": 50464.0, "length": 480, "protein_name": "Endothelial transcription factor GATA-2", "gene_name": "Gata2", "organism": "Rat", "refseq_name": "endothelial transcription factor GATA-2", "refseq_ac": [ { "id": "NP_254277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_254277", "type": "external" } ], "gene_names_uniprotkb": "Gata2", "gene_names_refseq": "Gata2", "protein_names_uniprotkb": "Endothelial transcription factor GATA-2; GATA-binding protein 2", "protein_names_refseq": "GATA-bindning protein 2; endothelial transcription factor GATA-2", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); immunodeficiency 21 (Disease Ontology:DOID:0111947); pre-eclampsia (Disease Ontology:DOID:10591); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:25159); (R-RNO-8939236); (R-RNO-983231)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "12933836", "class_list": "", "function": "Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHY4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0010725 regulation of primitive erythrocyte differentiation;GO:0035854 eosinophil fate commitment;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924Y4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Y8-1", "uniprot_id": [ { "id": "GP149_RAT", "url": "https://www.uniprot.org/uniprot/Q924Y8", "type": "external" } ], "mass": 80524.0, "length": 730, "protein_name": "Probable G protein-coupled receptor 149", "gene_name": "Gpr149", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 149 isoform 1", "refseq_ac": [ { "id": "NP_620246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620246", "type": "external" } ], "gene_names_uniprotkb": "Gpr149; Ieda", "gene_names_refseq": "Gpr149; Ieda", "protein_names_uniprotkb": "Probable G protein-coupled receptor 149; Induced early in differentiating astrocytes gene protein", "protein_names_refseq": "induced early in differentiating astrocytes gene protein; orphan seven transmembrane receptor; probable G-protein coupled receptor 149 isoform 1; probable G-protein coupled receptor 149", "tax_id": 10116, "disease": "", "pathway": " (rno:192251)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12065666", "class_list": "", "function": "Induced during early steps of astrocyte differentiation, Ieda transcripts were found exclusively in brain and testis. In developing rat brain, Ieda expression was first detected at embryonic day 16, two days before first appearance of mature astrocytes., [RefSeq, PubMed]; Orphan receptor., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0007218 neuropeptide signaling pathway;GO:0001546 preantral ovarian follicle growth;GO:0060280 negative regulation of ovulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924Y8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925Q4-1", "uniprot_id": [ { "id": "GPHA2_RAT", "url": "https://www.uniprot.org/uniprot/Q925Q4", "type": "external" } ], "mass": 14199.0, "length": 130, "protein_name": "Glycoprotein hormone alpha-2", "gene_name": "Gpha2", "organism": "Rat", "refseq_name": "glycoprotein hormone alpha-2 precursor", "refseq_ac": [ { "id": "NP_598303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598303", "type": "external" } ], "gene_names_uniprotkb": "Gpha2; Gpa2; Zsig51", "gene_names_refseq": "Gpa2; Gpha2; Zsig51", "protein_names_uniprotkb": "Glycoprotein hormone alpha-2; Putative secreted protein Zsig51; Thyrostimulin subunit alpha", "protein_names_refseq": "cysteine knot protein; glycoprotein hormone alpha 2; glycoprotein hormone alpha-2 precursor; glycoprotein-alpha 2; putative secreted protein ZSIG51; thyrostimulin subunit alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:171158); (R-RNO-375281)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15841792;16901922;19955180", "class_list": "", "function": "Data indicate that the presence of thyrostimulin in the ovary suggests that it may have a primitive function in reproduction when it activates ovarian TSHR., [RefSeq, PubMed]; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism., [UniProtKB, UniProtKB]; Results describe the differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary, and suggest that the thyrostimulin system is functionally different from the thyroid-stimulating hormone system., [RefSeq, PubMed]; Thyrostimulin immunoreactivity was visualized in the anterior pituitary, central nervous system, adrenal gland, stomach, duodenum, pancreas and testis; findings suggest that thyrostimulin is widely distributed [thyrostimulin], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005179 hormone activity;GO:0031531 thyrotropin-releasing hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925U2-1", "uniprot_id": [ { "id": "LTC4S_RAT", "url": "https://www.uniprot.org/uniprot/Q925U2", "type": "external" } ], "mass": 16850.0, "length": 150, "protein_name": "Leukotriene C4 synthase", "gene_name": "Ltc4s", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ltc4s", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukotriene C4 synthase; 2.5.1.-; 4.4.1.20; Glutathione S-transferase LTC4; LTC4 synthase; Leukotriene-C(4) synthase", "protein_names_refseq": "", "tax_id": 10116, "disease": "aspirin allergy (Disease Ontology:DOID:0040002); sinusitis (Disease Ontology:DOID:0050127); obstructive sleep apnea (Disease Ontology:DOID:0050848); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); allergic disease (Disease Ontology:DOID:1205); urticaria (Disease Ontology:DOID:1555); intrahepatic cholestasis (Disease Ontology:DOID:1852); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); cerebral infarction (Disease Ontology:DOID:3526); allergic rhinitis (Disease Ontology:DOID:4481); peripheral nervous system disease (Disease Ontology:DOID:574); periodontitis (Disease Ontology:DOID:824); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:114097); (R-RNO-2142688); (R-RNO-2142691); (R-RNO-2142700); (R-RNO-9026762); (R-RNO-9026766)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "12445492", "class_list": "", "function": "Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:12445492). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V6E6", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0071222 cellular response to lipopolysaccharide;GO:0048678 response to axon injury;GO:0006691 leukotriene metabolic process;GO:0019370 leukotriene biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q925U2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MF4-1", "uniprot_id": [ { "id": "I11RA_RAT", "url": "https://www.uniprot.org/uniprot/Q99MF4", "type": "external" } ], "mass": 46784.0, "length": 431, "protein_name": "Interleukin-11 receptor subunit alpha", "gene_name": "Il11ra1", "organism": "Rat", "refseq_name": "interleukin-11 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_620816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620816", "type": "external" } ], "gene_names_uniprotkb": "Il11ra1", "gene_names_refseq": "Il11ra1", "protein_names_uniprotkb": "Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA", "protein_names_refseq": "IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; interleukin 11 receptor, alpha chain 1; interleukin-11 receptor alpha chain; interleukin-11 receptor subunit alpha precursor; interleukin-11 receptor subunit alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:245983); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14701802;36521373", "class_list": "", "function": "Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Ralpha/STAT3 signaling pathway., [RefSeq, PubMed]; IL11RA has a role in apoptosis, [RefSeq, PubMed]; Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number., [UniProtKB, UniProtKB]; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0001890 placenta development;GO:0032502 developmental process;GO:0060135 maternal process involved in female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99MF4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PW5-1", "uniprot_id": [ { "id": "NEUR3_RAT", "url": "https://www.uniprot.org/uniprot/Q99PW5", "type": "external" } ], "mass": 46980.0, "length": 418, "protein_name": "Sialidase-3", "gene_name": "Neu3", "organism": "Rat", "refseq_name": "sialidase-3", "refseq_ac": [ { "id": "NP_446462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446462", "type": "external" } ], "gene_names_uniprotkb": "Neu3", "gene_names_refseq": "Neu3", "protein_names_uniprotkb": "Sialidase-3; 3.2.1.18; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3; Neuraminidase 3", "protein_names_refseq": "N-acetyl-alpha-neuraminidase 3; ganglioside sialidase; membrane sialidase; sialidase 3 (membrane sialidase); sialidase-3", "tax_id": 10116, "disease": "", "pathway": " (rno:117185); (R-RNO-4085001); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11162581;12730204;24523539;26022181", "class_list": "glycogene;glycosylhydrolase", "function": "Activation of Neu3 sialidase is an essential step in regeneration occurring in PNS (sensory) but not CNS (retinal) axons, [RefSeq, PubMed]; Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes., [UniProtKB, UniProtKB]; Findings implicate NEU3 as a potential biomarker of insulin sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression., [RefSeq, PubMed]; NEU3 participates in the control of insulin signaling via modulation of gangliosides and interaction with Grb2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497C0", "ec_number_list": [ { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" } ], "go_molecular_function": "GO:0016997 alpha-sialidase activity;GO:0004308 exo-alpha-sialidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0005975 carbohydrate metabolic process;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway;GO:0009313 oligosaccharide catabolic process;GO:1900186 negative regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99PW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPI9-1", "uniprot_id": [ { "id": "KCNH5_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPI9", "type": "external" } ], "mass": 111830.0, "length": 988, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH5", "gene_name": "Kcnh5", "organism": "Rat", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH5", "refseq_ac": [ { "id": "NP_598294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598294", "type": "external" } ], "gene_names_uniprotkb": "Kcnh5; Eag2", "gene_names_refseq": "Eag2; Kcnh5", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH5; Ether-a-go-go potassium channel 2; Potassium voltage-gated channel subfamily H member 5; Voltage-gated potassium channel subunit Kv10.2; rEAG2", "protein_names_refseq": "ether-a-go-go potassium channel 2; potassium channel, voltage gated eag related subfamily H, member 5; potassium voltage-gated channel, subfamily H (eag-related), member 5; rEAG2; voltage-gated delayed rectifier potassium channel KCNH5; voltage-gated potassium channel subunit Kv10.2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:171146); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10594062;10882483;15706225;18063306;20662937;24495567;38797494;9714851", "class_list": "", "function": "Compared to rEag2, rEag1 expression encompasses a significantly broader range of the somatodendritic compartment of the retinal ganglion cell., [RefSeq, PubMed]; Immunofluorescence studies using markers for different compartments of neurons demonstrated a differential expression pattern of rEag1 and rEag2 K channels in the somatodendritic region., [RefSeq, PubMed]; Isolation rearing changes the expression of Eag2 potassium channel in the midbrain, striatum, cortex, hippocampus and olfactory bult; and reduces exploratory activity in the center of an open field., [RefSeq, PubMed]; KCNH5 deletion increases autism susceptibility by regulating neuronal growth through Akt/mTOR signaling pathway., [RefSeq, PubMed]; Our findings suggest that Eag1 and Eag2 K+ channels may modulate membrane excitability in both the dendrosomatic and the axonal compartments and that Eag1 may additionally regulate neurotransmitter release and postsynaptic signaling Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10594062, PubMed:10882483). The kinetic is characterized by a slow activation time course and a small voltage dependence of the activation time constants, therefore, starts to open at more negative voltages (PubMed:10594062, PubMed:10882483). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:10594062, PubMed:10882483). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:10594062, PubMed:10882483). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation, therefore the activation rate depends on holding potential (PubMed:10594062, PubMed:10882483)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88893;Q9QXT2", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005516 calmodulin binding;GO:0044325 transmembrane transporter binding;GO:0044877 protein-containing complex binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0010389 regulation of G2/M transition of mitotic cell cycle;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9EPI9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPQ0-1", "uniprot_id": [ { "id": "NCKX3_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPQ0", "type": "external" } ], "mass": 69389.0, "length": 624, "protein_name": "Sodium/potassium/calcium exchanger 3", "gene_name": "Slc24a3", "organism": "Rat", "refseq_name": "sodium/potassium/calcium exchanger 3", "refseq_ac": [ { "id": "NP_445957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445957", "type": "external" } ], "gene_names_uniprotkb": "Slc24a3; Nckx3", "gene_names_refseq": "Nckx3; Slc24a3", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 3; Na(+)/K(+)/Ca(2+)-exchange protein 3; Solute carrier family 24 member 3", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 3; potassium-dependent sodium-calcium exchanger NCKX3 (SLC24A3); sodium/potassium/calcium exchanger 3; solute carrier family 24 (sodium/potassium/calcium exchanger), member 3", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:85267); (R-RNO-425561)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11294880;12218699;16617138;21104767;22673903", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)., [UniProtKB, PubMed]; MRNA encoding NCKX3 and NCKX4 was demonstrated by RT-PCR and Northern blot in both rat mesenteric and aortic smooth muscle providing evidence for their role in mediating vascular tone., [RefSeq, PubMed]; NCKX3 may be involved in reproductive function during the estrous cycle in female rats., [RefSeq, PubMed]; Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0016020 membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0006812 monoatomic cation transport;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPU2-1", "uniprot_id": [ { "id": "NCOA3_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPU2", "type": "external" } ], "mass": 115134.0, "length": 1082, "protein_name": "Nuclear receptor coactivator 3", "gene_name": "Ncoa3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncoa3; Aib1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor coactivator 3; 2.3.1.48; AIB-1; Amplified in breast cancer-1 protein homolog; NCoA-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84584); (R-RNO-5687128); (R-RNO-9018519); (R-RNO-9841922)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10906038;22673903;29393594", "class_list": "", "function": "Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070561 vitamin D receptor signaling pathway;GO:1902459 positive regulation of stem cell population maintenance;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EPU2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQD2-1", "uniprot_id": [ { "id": "NPFF2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQD2", "type": "external" } ], "mass": 47711.0, "length": 417, "protein_name": "Neuropeptide FF receptor 2", "gene_name": "Npffr2", "organism": "Rat", "refseq_name": "neuropeptide FF receptor 2", "refseq_ac": [ { "id": "NP_076470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076470", "type": "external" } ], "gene_names_uniprotkb": "Npffr2; Gpr74; Npff2; Npgpr", "gene_names_refseq": "Gpr74; Npff2; Npffr2; Npgpr", "protein_names_uniprotkb": "Neuropeptide FF receptor 2; G protein-coupled receptor 74; Neuropeptide G protein-coupled receptor", "protein_names_refseq": "G-protein coupled receptor 74; neuropeptide FF receptor 2; neuropeptide G-protein coupled receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:78964); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11024015;12421602;14696013;28825666", "class_list": "", "function": "In contrast to the rat spinal cord where the NPFF(1) system is absent, there is no strict separation between NPFF(1) and NPFF(2) system at the supraspinal level., [RefSeq, PubMed]; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB, PubMed]; The distribution pattern of NPFF2 receptors in the diencephalon and the superficial layers of the spinal cord is consistent with a hypothesized potential role for NPFF in the modulation of sensory input and opioid analgesia., [RefSeq, PubMed]; We demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EQD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER26-1", "uniprot_id": [ { "id": "KCNS2_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER26", "type": "external" } ], "mass": 54317.0, "length": 477, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS2", "gene_name": "Kcns2", "organism": "Rat", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS2", "refseq_ac": [ { "id": "NP_076456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076456", "type": "external" } ], "gene_names_uniprotkb": "Kcns2", "gene_names_refseq": "Kcns2", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS2; Delayed-rectifier K(+) channel alpha subunit 2; Delayed-rectifier potassium channel subunit Kv9.2; Potassium voltage-gated channel subfamily S member 2", "protein_names_refseq": "delayed-rectifier K(+) channel alpha subunit 2; delayed-rectifier potassium channel regulatory subunit KCNS2; delayed-rectifier potassium channel subunit Kv9.2; potassium channel, alpha subunit (kv9.2 gene); potassium voltage-gated channel subfamily S member 2; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2; voltage-gated potassium channel subunit Kv9.2", "tax_id": 10116, "disease": "", "pathway": " (rno:66022); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11891605", "class_list": "", "function": "Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ER26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERS1-1", "uniprot_id": [ { "id": "KCNKC_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERS1", "type": "external" } ], "mass": 46965.0, "length": 430, "protein_name": "Potassium channel subfamily K member 12", "gene_name": "Kcnk12", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 12", "refseq_ac": [ { "id": "NP_071628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071628", "type": "external" } ], "gene_names_uniprotkb": "Kcnk12", "gene_names_refseq": "Kcnk12; THIK-2", "protein_names_uniprotkb": "Potassium channel subfamily K member 12; THIK-2; Tandem pore domain halothane-inhibited potassium channel 2", "protein_names_refseq": "potassium channel subfamily K member 12; potassium channel, subfamily K, member 12; potassium channel, two pore domain subfamily K, member 12; tandem pore domain halothane-inhibited potassium channel 2; tandem pore domain potassium channel THIK-2", "tax_id": 10116, "disease": "", "pathway": " (rno:64119); (R-RNO-5576886)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11060316;18209473;24297522", "class_list": "", "function": "K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The homodimers are mainly retained in the endoplasmic reticulum compartment and may be targeted to the cell surface upon phosphorylation or other activation signals yet to be elucidated., [UniProtKB, UniProtKB]; THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney., [RefSeq, PubMed]; The characteristics of THIK-2 channels can be analysed in heterologous expression systems by using trafficking and/or gating mutants, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES08-1", "uniprot_id": [ { "id": "KCNK9_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES08", "type": "external" } ], "mass": 44357.0, "length": 396, "protein_name": "Potassium channel subfamily K member 9", "gene_name": "Kcnk9", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 9 precursor", "refseq_ac": [ { "id": "NP_445857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445857", "type": "external" } ], "gene_names_uniprotkb": "Kcnk9; Task3", "gene_names_refseq": "Kcnk9; Task-3; Task3", "protein_names_uniprotkb": "Potassium channel subfamily K member 9; Acid-sensitive potassium channel protein TASK-3; TWIK-related acid-sensitive K(+) channel 3; Two pore K(+) channel KT3.2; Two pore potassium channel KT3.2", "protein_names_refseq": "TWIK-related acid-sensitive K(+) channel 3; acid-sensitive potassium channel protein TASK-3; potassium channel subfamily K member 9 precursor; potassium channel subfamily K member 9; potassium channel, subfamily K, member 9 (Task-3); potassium channel, two pore domain subfamily K, member 9; two pore K(+) channel KT3.2; two pore potassium channel KT3.2", "tax_id": 10116, "disease": "Birk-Barel syndrome (Disease Ontology:DOID:0050675)", "pathway": " (rno:84429); (R-RNO-1299316); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10734076;11431495;11749039;11875121;14678492;15282272;23219908;24077856;25405940;25634809;31472119", "class_list": "", "function": "Hydroxy-alpha sanshool evokes colonic motility via blockage of the neural KCNK9 channel in the colonic myenteric plexus., [RefSeq, PubMed]; In the dorsal horn of the developing rat, TWIK-related acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were down-regulated during postnatal development, [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity) (PubMed:10734076, PubMed:11875121, PubMed:14678492, PubMed:15282272). Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:14678492, PubMed:15282272). Allows K(+) currents with fast-gating kinetics important for the repolarization and hyperpolarization phases of action potentials (By similarity). In granule neurons, hyperpolarizes the resting membrane potential to limit intrinsic neuronal excitability, but once the action potential threshold is reached, supports high-frequency action potential firing and increased neuronal excitability. Homomeric and/or heteromeric KCNK3:KCNK9 channels operate in cerebellar granule cells, whereas heteromeric KCNK1:KCNK9 enables currents in hippocampal dentate gyrus granule neurons (By similarity) (PubMed:14678492). Dispensable for central chemosensory respiration i.e. breathing controlled by brainstem CO2/pH, it rather conducts pH-sensitive currents and controls the firing rate of serotonergic raphe neurons involved in potentiation of the respiratory chemoreflex (By similarity). In retinal ganglion cells, mediates outward rectifying currents that regulate action potentials in response to acidification of the synaptic cleft. Involved in transmission of image-forming and nonimage-forming visual information in the retina (By similarity). In adrenal gland, contributes to the maintenance of a hyperpolarized resting membrane potential of aldosterone-producing cells at zona glomerulosa and limits aldosterone release as part of a regulatory mechanism that controls arterial blood pressure and electrolyte homeostasis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Results demonstrate that neurotensin (NT) transiently increased the neuronal excitability of dentate gyrus granule cells (GCs) by inhibiting TASK-3 channels; NT-mediated increases in neuronal excitability facilitate long-term potentiation at the perforant path-GC synapses, [RefSeq, PubMed]; Study analyzed TASK-1 and TASK-3 expression in ipsilateral and contralateral dorsal root ganglia and dorsal and ventral spinal cord of naive and formalin-treated or nerve injured rats. Pharmacological and molecular data suggest that TASK-1 and TASK-3 reduce the nociceptive transmission in acute/chronic inflammatory and neuropathic pain suggesting antinociceptive role of these channels in inflammatory and neuropathic pain., [RefSeq, PubMed]; TASK-3 dominates the resting potassium conductance of zona glomerulosa cells, [RefSeq, PubMed]; The entire rat brain was immunocytochemically analyzed for expression of TASK-3 protein., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q923V6;Q9JLD4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0008021 synaptic vesicle;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007601 visual perception;GO:0006813 potassium ion transport;GO:0060075 regulation of resting membrane potential;GO:1990573 potassium ion import across plasma membrane;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9ES08-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESK8-1", "uniprot_id": [ { "id": "KCMB4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESK8", "type": "external" } ], "mass": 23885.0, "length": 210, "protein_name": "Calcium-activated potassium channel subunit beta-4", "gene_name": "Kcnmb4", "organism": "Rat", "refseq_name": "calcium-activated potassium channel subunit beta-4", "refseq_ac": [ { "id": "NP_076450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076450", "type": "external" } ], "gene_names_uniprotkb": "Kcnmb4", "gene_names_refseq": "Kcnmb4", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel subunit beta-4; Slo-beta-4", "protein_names_refseq": "BK channel subunit beta-4; BKbeta4; calcium activated potassium channel beta 4 subunit; calcium-activated potassium channel subunit beta-4; calcium-activated potassium channel, subfamily M subunit beta-4; charybdotoxin receptor subunit beta-4; k(VCA)beta-4; maxi K channel subunit beta-4; potassium channel subfamily M regulatory beta subunit 4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; slo-beta-4", "tax_id": 10116, "disease": "", "pathway": " (rno:66016); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17068255;21848922;24486049;25344764;32070382;32653540", "class_list": "", "function": "Brain BKCa channels are assembled into complexes with calcium channels Cav1.2, Cav2.1 & Cav2.2; complex formation with Cav channels enables BKCa-mediated membrane hyperpolarization controlling neuronal firing & release of hormones & transmitters, [RefSeq, PubMed]; Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 beta4-subunit Expression., [RefSeq, PubMed]; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability, [RefSeq, PubMed]; The results demonstrate a modification in the mitochondrial BKCa channel gating properties in membrane preparations coming from a streptozotocin model of diabetic rats, an effect potentially linked to a change in BKCa beta4 and alpha subunits expression., [RefSeq, PubMed]; These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels., [RefSeq, PubMed]; Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0005513 detection of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESQ4-1", "uniprot_id": [ { "id": "NMUR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESQ4", "type": "external" } ], "mass": 44723.0, "length": 395, "protein_name": "Neuromedin-U receptor 2", "gene_name": "Nmur2", "organism": "Rat", "refseq_name": "neuromedin-U receptor 2", "refseq_ac": [ { "id": "NP_071611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071611", "type": "external" } ], "gene_names_uniprotkb": "Nmur2; NMU2R; Tgr1", "gene_names_refseq": "FM-4; Nmu2r; Nmur2", "protein_names_uniprotkb": "Neuromedin-U receptor 2; FM-4; G protein-coupled receptor FM-4; G protein-coupled receptor TGR-1; NMU-R2; TGR-1", "protein_names_refseq": "G-protein coupled receptor TGR-1; G-protein-coupled receptor FM-4; NMU-R2; neuromedin-U receptor 2", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64042); (R-RNO-375276); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10887190;10894543;15631899;15635449;23423171;24269937;30227148;30914203;31069918", "class_list": "", "function": "Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents., [RefSeq, PubMed]; G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10887190, PubMed:10894543, PubMed:15635449). Functionally, is involved in regulation of feeding and energy balance (PubMed:10894543). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; NMU and NMU receptor 2 compose a novel autocrine system in theca/interstitial cells in which the intensity of signaling is tightly controlled by gonadotropins., [RefSeq, PubMed]; NMUR2 is upregulated in bone cancer pain rat model. Short interference RNA NMUR2 alleviates nociception in bone cancer pain rat model., [RefSeq, PubMed]; Receptor for the neuromedin-U and neuromedin-S neuropeptides., [UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods without disrupting feeding behavior associated with non-obesogenic standard chow, [RefSeq, PubMed]; These results suggest that NMU modulates the function of the PVN putative parvocellular neurons and is involved in the regulation of OTergic and VPergic neurons by enhanced HCN ion channels activity via NMU-receptor 2., [RefSeq, PubMed]; This study shown that modulation of neuromedin U receptor 2 (NMUR2) in the paraventricular nucleus of the hypothalamus (PVN) results in increased food intake and motivation for energy-dense foods., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIB1", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0008188 neuropeptide receptor activity;GO:0001607 neuromedin U receptor activity;GO:0042924 neuromedin U binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0050482 arachidonate secretion;GO:0051930 regulation of sensory perception of pain;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007625 grooming behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9ESQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET55-1", "uniprot_id": [ { "id": "NOCT_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET55", "type": "external" } ], "mass": 48122.0, "length": 428, "protein_name": "Nocturnin", "gene_name": "Noct", "organism": "Rat", "refseq_name": "nocturnin", "refseq_ac": [ { "id": "NP_612535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612535", "type": "external" } ], "gene_names_uniprotkb": "Noct; Ccr4; Ccrn4l; Noc", "gene_names_refseq": "Ccr4; Ccrn4lb; Ccrn4l; Noct", "protein_names_uniprotkb": "Nocturnin; 3.1.3.108; Carbon catabolite repression 4-like protein", "protein_names_refseq": "CCR4 carbon catabolite repression 4-like B; CCR4 protein homolog; carbon catabolite epression 4 homolog; carbon catabolite repression 4-like protein; circadian deadenylase NOC; nocturin; nocturnin", "tax_id": 10116, "disease": "", "pathway": " (rno:310395)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7F4", "ec_number_list": [ { "id": "3.1.3.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.108", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0019178 NADP phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006739 NADP+ metabolic process;GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9ET55-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHE8-1", "uniprot_id": [ { "id": "NINJ2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHE8", "type": "external" } ], "mass": 15996.0, "length": 144, "protein_name": "Ninjurin-2", "gene_name": "Ninj2", "organism": "Rat", "refseq_name": "ninjurin-2", "refseq_ac": [ { "id": "NP_067606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067606", "type": "external" } ], "gene_names_uniprotkb": "Ninj2", "gene_names_refseq": "Ninj2", "protein_names_uniprotkb": "Ninjurin-2; Nerve injury-induced protein 2", "protein_names_refseq": "nerve injury-induced protein 2; ninjurin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:59115)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34320458", "class_list": "", "function": "Its role in unclear. In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death. While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture. May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration. Promotes axonal growth., [UniProtKB, UniProtKB]; Spinal Ninjurin2 contributes to the neuropathic pain via NF-kappaB-mediated neuroinflammation in the spared sciatic nerve injury rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042246 tissue regeneration;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JHE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI24-1", "uniprot_id": [ { "id": "IL24_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI24", "type": "external" } ], "mass": 21096.0, "length": 183, "protein_name": "Interleukin-24", "gene_name": "Il24", "organism": "Rat", "refseq_name": "interleukin-24 precursor", "refseq_ac": [ { "id": "NP_579845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579845", "type": "external" } ], "gene_names_uniprotkb": "Il24; Mob5", "gene_names_refseq": "If2e; Il24; Mda-7; Mda7", "protein_names_uniprotkb": "Interleukin-24; Cytokine-like protein Mob-5; IL-24", "protein_names_refseq": "IL-24; cytokine-like protein Mob-5; interferon 2e; interleukin-24 precursor", "tax_id": 10116, "disease": "periodontal disease (Disease Ontology:DOID:3388)", "pathway": " (rno:170819); (R-RNO-8854691)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10825166;23869901;28253513;33683657", "class_list": "", "function": "IL-24 has a potential treatment effect on cancers not only by inhibiting tumor proliferation, but also by the promotion of beta-endorphin synthesis, inhibition of IL-6 secretion to relieve cancer pain., [RefSeq, PubMed]; In studies of Congenital obstructive nephropathy in rat, it was found that il24 was upregulated and that il24 decreases the expression of IL-6 and MMP-3 in the renal epithelial cells., [RefSeq, PubMed]; Interleukin-24 as a Pulmonary Target Cytokine in Bronchopulmonary Dysplasia., [RefSeq, PubMed]; Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JI24-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIS4-1", "uniprot_id": [ { "id": "KCNKA_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIS4", "type": "external" } ], "mass": 59801.0, "length": 538, "protein_name": "Potassium channel subfamily K member 10", "gene_name": "Kcnk10", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 10", "refseq_ac": [ { "id": "NP_075584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075584", "type": "external" } ], "gene_names_uniprotkb": "Kcnk10; Trek2", "gene_names_refseq": "Kcnk10; TREK2", "protein_names_uniprotkb": "Potassium channel subfamily K member 10; Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit", "protein_names_refseq": "TREK-2 K(+) channel subunit; outward rectifying potassium channel protein TREK-2; potassium channel TREK-2; potassium channel subfamily K member 10; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:65272); (R-RNO-1299503); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10747911;11897089;11897838;12122143;25886567;27609046;29980241;34461754;35907583", "class_list": "", "function": "Characterization in cerebellar granule neurons, [RefSeq, PubMed]; Data do not suggest a relevant impact of miRNA expression patterns on the pharmacoresponsiveness of temporal lobe epilepsy; but confirmed the regulation of the previously described miRNA-187-3p and demonstrated that its regulation can exert an impact on the expression of the two-pore domain potassium channel protein KCNK10/TREK-2., [RefSeq, PubMed]; Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation., [RefSeq, PubMed]; Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain., [RefSeq, PubMed]; Is functionally expressed in cortical astrocytes in culture, and may be involved in K+ homeostasis of astrocytes during pathological states, [RefSeq, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+) (By similarity) (PubMed:10747911)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Strong immunoreactivity of TRAAK, TREK-1 and TREK-2 channels was present mainly in small-sized dorsal root ganglion (DRG) neurons of rats. Publication Status: Online-Only, [RefSeq, PubMed]; Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis.TREK-2 channels are up-regulated in the astrocytic membrane during ischemia. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q548D8", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0007613 memory;GO:0071805 potassium ion transmembrane transport;GO:1904551 cellular response to arachidonate;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JIS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ54-1", "uniprot_id": [ { "id": "HNRPD_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ54", "type": "external" } ], "mass": 38218.0, "length": 353, "protein_name": "Heterogeneous nuclear ribonucleoprotein D0", "gene_name": "Hnrnpd", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein D0 isoform b", "refseq_ac": [ { "id": "NP_001076008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076008", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpd; Auf1; Hnrpd", "gene_names_refseq": "Auf1; Hnrnpd; Hnrpd", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein D0; AU-rich element RNA-binding protein 1; hnRNP D0", "protein_names_refseq": "AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; RNA binding protein p45AUF1; heterogeneous nuclear ribonucleoprotein D0 isoform b; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0", "tax_id": 10116, "disease": "uremia (Disease Ontology:DOID:4676); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:79256); (R-RNO-450408); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "16396499;18492485;2088340;22673903;28986222;38843836", "class_list": "", "function": "AUF1 might be a potential player in renal tubulointerstitial fibrosis through modulation of TGF-beta signal transduction via posttranscriptional regulation of Nedd4L., [RefSeq, PubMed]; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V9G2;P17132;Q9JJ51;Q9JJ52;Q9JJ53", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:1904383 response to sodium phosphate;GO:0001889 liver development;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJ54-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJH2-1", "uniprot_id": [ { "id": "GP173_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJH2", "type": "external" } ], "mass": 41511.0, "length": 373, "protein_name": "Probable G protein-coupled receptor 173", "gene_name": "Gpr173", "organism": "Rat", "refseq_name": "probable G-protein coupled receptor 173", "refseq_ac": [ { "id": "NP_071591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071591", "type": "external" } ], "gene_names_uniprotkb": "Gpr173; Sreb3", "gene_names_refseq": "Gpr173; Sreb3", "protein_names_uniprotkb": "Probable G protein-coupled receptor 173; Super conserved receptor expressed in brain 3", "protein_names_refseq": "probable G-protein coupled receptor 173-like; probable G-protein coupled receptor 173; super conserved receptor expressed in brain 3", "tax_id": 10116, "disease": "", "pathway": " (rno:64021)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10833454;27440717;30251651;31422055;32505354", "class_list": "", "function": "Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (PubMed:27440717). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland (PubMed:27440717). In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth (By similarity)., [UniProtKB, PubMed, UniProtKB]; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth., [UniProtKB, UniProtKB]; Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome., [RefSeq, PubMed]; These studies are the first to demonstrate a functional relationship between PNX and Gpr173 in reproductive physiology and identify a potential therapeutic target for ovulatory dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:2001223 negative regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK96-1", "uniprot_id": [ { "id": "KCNQ4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK96", "type": "external" } ], "mass": 77061.0, "length": 695, "protein_name": "Potassium voltage-gated channel subfamily KQT member 4", "gene_name": "Kcnq4", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily KQT member 4", "refseq_ac": [ { "id": "NP_001406504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406504", "type": "external" } ], "gene_names_uniprotkb": "Kcnq4", "gene_names_refseq": "Kcnq4", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4", "protein_names_refseq": "KQT-like 4; potassium channel subunit alpha KvLQT4; potassium channel, voltage-gated KQT-like subfamily Q, member 4; potassium voltage-gated channel subfamily KQT member 4; potassium voltage-gated channel, KQT-like subfamily, member 4; voltage-gated potassium channel subunit Kv7.4", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 2A (Disease Ontology:DOID:0110558); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:298496)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11042367;12657673;24558103;25965962;27789473;28189443;29775679", "class_list": "", "function": "Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered., [RefSeq, PubMed]; EPAC-dependent vasorelaxations occur in part via activation of Kv7 channels. This contributes to the isoproterenol-mediated relaxation in mesenteric, but not renal, arteries., [RefSeq, PubMed]; In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP., [RefSeq, PubMed]; Is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone., [RefSeq, PubMed]; KCNQ channels set the resting membrane potential of inner hair cells in the isolated organ of Corti and maintain [Ca2+]i at low levels, [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound., [UniProtKB, UniProtKB]; Results indicate that midbrain Kcnq4 expression regulates alcohol-related behaviors and provide evidence that KV7.4 channels are a critical mediator of excessive alcohol drinking., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K666", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0009925 basal plasma membrane;GO:0034702 monoatomic ion channel complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0006813 potassium ion transport;GO:0007605 sensory perception of sound;GO:0032227 negative regulation of synaptic transmission, dopaminergic", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JK96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKU3-1", "uniprot_id": [ { "id": "IF172_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKU3", "type": "external" } ], "mass": 197603.0, "length": 1749, "protein_name": "Intraflagellar transport protein 172 homolog", "gene_name": "Ift172", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ift172; AABR07063281.1; Slb", "gene_names_refseq": "", "protein_names_uniprotkb": "Intraflagellar transport protein 172 homolog; Selective LIM-binding factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); polycystic kidney disease (Disease Ontology:DOID:0080322); Bardet-Biedl syndrome 20 (Disease Ontology:DOID:0081009); short-rib thoracic dysplasia 10 with or without polydactyly (Disease Ontology:DOID:0110091); retinitis pigmentosa 71 (Disease Ontology:DOID:0110363); VACTERL association (Disease Ontology:DOID:14679); cystic kidney disease (Disease Ontology:DOID:2975); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:116475); (R-RNO-5610787); (R-RNO-5620924)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10788441", "class_list": "", "function": "Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005634 nucleus;GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0061525 hindgut development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKU3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLD2-1", "uniprot_id": [ { "id": "NEUS_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLD2", "type": "external" } ], "mass": 46278.0, "length": 410, "protein_name": "Neuroserpin", "gene_name": "Serpini1", "organism": "Rat", "refseq_name": "neuroserpin precursor", "refseq_ac": [ { "id": "NP_446231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446231", "type": "external" } ], "gene_names_uniprotkb": "Serpini1; Pi12; Spi17", "gene_names_refseq": "PI-12; Serpini1; raPIT5a", "protein_names_uniprotkb": "Neuroserpin; PI-12; Peptidase inhibitor 12; Serine protease inhibitor 17; Serpin I1", "protein_names_refseq": "neuroserpin precursor; neuroserpin; peptidase inhibitor 12; protease inhibitor 17; serine (or cysteine) peptidase inhibitor, clade I, member 1; serine (or cysteine) proteinase inhibitor clade member 1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; serine protease inhibitor 17; serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; serpin peptidase inhibitor, clade I, member 1", "tax_id": 10116, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831)", "pathway": " (rno:116459)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10642518;11935397;12438159;16849336;22673903;24608243;25363759;25874935", "class_list": "", "function": "Neuroserpin has a role in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes Publication Status: Online-Only, [RefSeq, PubMed]; Neuroserpin interacts with Abeta(1-42) to form off-pathway non-toxic oligomers and so protects neurons in Alzheimer disease, [RefSeq, PubMed]; Neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration, [RefSeq, PubMed]; Novel intracellular serpin from the rat pituitary gland; data suggest raPIT5a may regulate apoptosis in the pituitary by inhibition of granzyme B or GLP IIIa, or members of the caspase enzyme family., [RefSeq, PubMed]; Rats overexpressing neuroserpin also showed a significant decrease in the levels of postsynaptic density protein 95, a major postsynaptic scaffolding protein. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator., [UniProtKB, PubMed]; The majority of the mutant neuroserpin proteins were found to fold correctly and could still form inhibitory complexes with tissue plasminogen activator (tPA)., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLD1", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0060205 cytoplasmic vesicle lumen", "go_biological_process": "GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JLD2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NQR8-1", "uniprot_id": [ { "id": "NDUF4_RAT", "url": "https://www.uniprot.org/uniprot/Q9NQR8", "type": "external" } ], "mass": 20158.0, "length": 174, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "gene_name": "Gpr63; Ndufaf4", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "refseq_ac": [ { "id": "NP_942078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942078", "type": "external" } ], "gene_names_uniprotkb": "Gpr63; Ndufaf4; Hrpap20; Ndufaf4", "gene_names_refseq": "Hrpap20; Ndufaf4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Hormone-regulated proliferation-associated protein of 20 kDa homolog; Protein HRPAP20", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; NADH dehydrogenase (ubiquinone) complex I, assembly factor 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; hormone-regulated proliferation associated protein 20; hormone-regulated proliferation-associated 20 kDa protein; hormone-regulated proliferation-associated protein of 20 kDa homolog", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 15 (Disease Ontology:DOID:0112077)", "pathway": " (rno:297952); (rno:362495); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14871833;27213235", "class_list": "", "function": "May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity)., [UniProtKB, PubMed]; Orphan receptor. May play a role in brain function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0051607 defense response to virus;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0010257 NADH dehydrogenase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9NQR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUK5-1", "uniprot_id": [ { "id": "HSPB7_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUK5", "type": "external" } ], "mass": 9804.0, "length": 90, "protein_name": "Heat shock protein beta-7", "gene_name": "Hspb7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hspb7; Cvhsp", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein beta-7; Cardiovascular heat shock protein; HspB7; cvHsp", "protein_names_refseq": "", "tax_id": 10116, "disease": "heart disease (Disease Ontology:DOID:114)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10593960", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031005 filamin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0015030 Cajal body", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QUK5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXT3-1", "uniprot_id": [ { "id": "NAT8_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXT3", "type": "external" } ], "mass": 24894.0, "length": 222, "protein_name": "N-acetyltransferase 8", "gene_name": "Nat8", "organism": "Rat", "refseq_name": "N-acetyltransferase 8", "refseq_ac": [ { "id": "NP_072157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072157", "type": "external" } ], "gene_names_uniprotkb": "Nat8; Cml4", "gene_names_refseq": "CCNAT; Cml4; Nat8", "protein_names_uniprotkb": "N-acetyltransferase 8; 2.3.1.-; 2.3.1.80; ATase2; Acetyltransferase 2; CCNAT; Camello-like protein 4; Cysteinyl-conjugate N-acetyltransferase; Protein-lysine N6-acetyltransferase 8", "protein_names_refseq": "ATase2; N-acetyltransferase 8 (camello like); N-acetyltransferase 8; acetyltransferase 2; camello-like 4; camello-like protein 4; cysteinyl-conjugate N-acetyltransferase; probable N-acetyltransferase CML4; protein-lysine N6-acetyltransferase 8; putative N-acetyltransferase Camello 4", "tax_id": 10116, "disease": "", "pathway": " (rno:64570)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11397015;6892478", "class_list": "", "function": "Endoplasmic reticulum-membrane(ER)-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (By similarity). N(6)-lysine acetylation in the ER maintains protein homeostasis and regulates reticulophagy (By similarity). Alternatively, acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (Probable). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IAT5", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0047198 L-cysteine-S-conjugate N-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0001702 gastrulation with mouth forming second;GO:0018003 peptidyl-lysine N6-acetylation;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QXT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYC6-1", "uniprot_id": [ { "id": "GPR37_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYC6", "type": "external" } ], "mass": 66961.0, "length": 603, "protein_name": "Prosaposin receptor GPR37", "gene_name": "Gpr37", "organism": "Rat", "refseq_name": "prosaposin receptor GPR37 precursor", "refseq_ac": [ { "id": "NP_476549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476549", "type": "external" } ], "gene_names_uniprotkb": "Gpr37", "gene_names_refseq": "Ednrbl; Gpr37", "protein_names_uniprotkb": "Prosaposin receptor GPR37; G protein-coupled receptor 37; G protein-coupled receptor CNS1", "protein_names_refseq": "G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor CNS1; probable G-protein coupled receptor 37; prosaposin receptor GPR37 precursor; prosaposin receptor GPR37", "tax_id": 10116, "disease": "Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:117549); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10350639;12618056;24749734;29656342;31215019;33259479", "class_list": "", "function": "Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats., [RefSeq, PubMed]; Expression of Pael-R genes in the nigro-striatal pathway may have significant implication for pathophysiology and treatment of parkinson disease., [RefSeq, PubMed]; G protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PICK1 interacts with parkin and our data showed that PICK1 reduces PAELR expression levels in transiently transfected heterologous cells, [RefSeq, PubMed]; Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection. Publication Status: Online-Only, [RefSeq, PubMed]; The present findings indicate that PSAP and its receptors, GPR37 and GPR37L1, are expressed in the major salivary glands of rats and their immunoreactivities differ considerably with age and sex., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036505 prosaposin receptor activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0030165 PDZ domain binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0016358 dendrite development;GO:0043410 positive regulation of MAPK cascade;GO:0031987 locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QYC6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ2-1", "uniprot_id": [ { "id": "PODXL_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ2", "type": "external" } ], "mass": 51658.0, "length": 485, "protein_name": "Podocalyxin", "gene_name": "Podxl", "organism": "Rat", "refseq_name": "podocalyxin precursor", "refseq_ac": [ { "id": "NP_620203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620203", "type": "external" } ], "gene_names_uniprotkb": "Podxl; Pclp1", "gene_names_refseq": "PCLP-1; PC; Podxl; podocalyxin", "protein_names_uniprotkb": "Podocalyxin; PCLP-1; PC; Podocalyxin-like protein 1", "protein_names_refseq": "podocalyxin precursor; podocalyxin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192181)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10982412;11457882;15226400;19684413;21945805;24419512;25003484;36934678;38843836", "class_list": "", "function": "Both the overexpression of CTGF and the loss of podocalyxin reflect renal damage in spontaneously hypertensive rats. CTGF and PCX may be involved in the mechanisms of podocyte injury and apoptosis induced by hypertension, [RefSeq, PubMed]; Cortactin mediates interaction between podocalyxin and actin filaments in podocytes and that alteration of this interaction may play a role in the process of morphological change of podocytes., [RefSeq, PubMed]; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia., [RefSeq, PubMed]; Podocalyxin has a role in defining the structure of the podocyte basal surface, [RefSeq, PubMed]; The immunohistochemical expression of caveolin-1 and podocalyxin in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRK7;Q9R068", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0045121 membrane raft", "go_biological_process": "GO:0072175 epithelial tube formation;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9WTQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T7-1", "uniprot_id": [ { "id": "ICOS_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1T7", "type": "external" } ], "mass": 22529.0, "length": 200, "protein_name": "Inducible T-cell costimulator", "gene_name": "Icos", "organism": "Rat", "refseq_name": "inducible T-cell costimulator isoform 1 precursor", "refseq_ac": [ { "id": "NP_072132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072132", "type": "external" } ], "gene_names_uniprotkb": "Icos; Ailim", "gene_names_refseq": "Ailim; Icos", "protein_names_uniprotkb": "Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule", "protein_names_refseq": "activation-inducible lymphocyte immunomediatory molecule; inducible T-cell costimulator isoform 1 precursor; inducible T-cell costimulator", "tax_id": 10116, "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); colitis (Disease Ontology:DOID:0060180); common variable immunodeficiency 1 (Disease Ontology:DOID:0081144); celiac disease (Disease Ontology:DOID:10608); common variable immunodeficiency (Disease Ontology:DOID:12177); uveitis (Disease Ontology:DOID:13141); myocarditis (Disease Ontology:DOID:820)", "pathway": " (rno:64545); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9927354)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11006126;24909668;26436531;27323062;31153660", "class_list": "", "function": "ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines Publication Status: Online-Only, [RefSeq, PubMed]; ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis., [RefSeq, PubMed]; Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (By similarity). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (By similarity). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The increased expression of ICOS/ICOS ligand in periapical lesions was associated with the inflammatory infiltration and alveolar bone destruction of apical periodontitis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVR9", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0098609 cell-cell adhesion;GO:0002517 T cell tolerance induction;GO:0061470 T follicular helper cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R1T7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUI9-1", "uniprot_id": [ { "id": "NCOA2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUI9", "type": "external" } ], "mass": 159436.0, "length": 1465, "protein_name": "Nuclear receptor coactivator 2", "gene_name": "Ncoa2", "organism": "Rat", "refseq_name": "nuclear receptor coactivator 2", "refseq_ac": [ { "id": "NP_114010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114010", "type": "external" } ], "gene_names_uniprotkb": "Ncoa2; Tif2", "gene_names_refseq": "GRIP-1; Grip1; Ncoa2; Tif2", "protein_names_uniprotkb": "Nuclear receptor coactivator 2; NCoA-2; Transcriptional intermediary factor 2", "protein_names_refseq": "NCoA-2; glucocorticoid receptor interacting protein 1; nuclear receptor coactivator 2; transcriptional intermediary factor 2", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); polycystic ovary syndrome (Disease Ontology:DOID:11612); prostate adenocarcinoma (Disease Ontology:DOID:2526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); malignant pleural mesothelioma (Disease Ontology:DOID:7474); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:83724); (R-RNO-159418); (R-RNO-192105); (R-RNO-193368); (R-RNO-193807); (R-RNO-211976); (R-RNO-3214847); (R-RNO-400206); (R-RNO-5625886); (R-RNO-9707564); (R-RNO-9841922)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "22673903;31272713;9742117", "class_list": "", "function": "The data suggest that alterations of histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus and the inability of Ncoa2 and Crebbp to respond to estradiol in the middle-aged anterior hypothalamus partially contribute to the decline of GnRH neuron activation and estradiol target gene expression changes that occur in females along with reproductive aging., [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043197 dendritic spine;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WUI9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0J8-1", "uniprot_id": [ { "id": "NEGR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0J8", "type": "external" } ], "mass": 37858.0, "length": 348, "protein_name": "Neuronal growth regulator 1", "gene_name": "Negr1", "organism": "Rat", "refseq_name": "neuronal growth regulator 1 precursor", "refseq_ac": [ { "id": "NP_067714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067714", "type": "external" } ], "gene_names_uniprotkb": "Negr1", "gene_names_refseq": "Negr1", "protein_names_uniprotkb": "Neuronal growth regulator 1; Kilon; Kindred of IgLON", "protein_names_refseq": "kilon protein; kindred of IgLON; neuronal growth regulator 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:59318); (R-RNO-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10075727;18602091;18729387;22627920;38843836", "class_list": "", "function": "Expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is affected by nutritional state in these two areas, and the relationship, [RefSeq, PubMed]; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity)., [UniProtKB]; These results demonstrate the alteration of modulatory function of Kilon for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:0060538 skeletal muscle organ development;GO:0007626 locomotory behavior;GO:0010976 positive regulation of neuron projection development;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9Z0J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Z6-1", "uniprot_id": [ { "id": "ILKAP_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1Z6", "type": "external" } ], "mass": 42744.0, "length": 392, "protein_name": "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "gene_name": "Ilkap", "organism": "Rat", "refseq_name": "integrin-linked kinase-associated serine/threonine phosphatase 2C", "refseq_ac": [ { "id": "NP_072128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072128", "type": "external" } ], "gene_names_uniprotkb": "Ilkap", "gene_names_refseq": "Ilkap", "protein_names_uniprotkb": "Integrin-linked kinase-associated serine/threonine phosphatase 2C; 3.1.3.16; ILKAP; PP2Cdelta", "protein_names_refseq": "PP2Cdelta; integrin-linked kinase-associated serine/threonine phosphatase 2C; protein phosphatase 2C", "tax_id": 10116, "disease": "", "pathway": " (rno:64538)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14663150;9857069", "class_list": "", "function": "Distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C, [RefSeq, PubMed]; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6U8", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0007165 signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1Z6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZED8-1", "uniprot_id": [ { "id": "D3ZED8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZED8", "type": "external" } ], "mass": 72651.0, "length": 680, "protein_name": "Premelanosome protein", "gene_name": "Pmel", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pmel", "gene_names_refseq": "", "protein_names_uniprotkb": "Premelanosome protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZED8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2QC27-1", "uniprot_id": [ { "id": "A0A0G2QC27_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2QC27", "type": "external" } ], "mass": 128069.0, "length": 1146, "protein_name": "Nucleolar protein 6", "gene_name": "Nol6", "organism": "Rat", "refseq_name": "nucleolar protein 6", "refseq_ac": [ { "id": "NP_001414130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414130", "type": "external" } ], "gene_names_uniprotkb": "Nol6", "gene_names_refseq": "Nol6", "protein_names_uniprotkb": "Nucleolar protein 6", "protein_names_refseq": "nucleolar protein 6 (RNA-associated); nucleolar protein 6; nucleolar protein family 6 (RNA-associated)", "tax_id": 10116, "disease": "", "pathway": " (rno:313167); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0032040 small-subunit processome;GO:0032545 CURI complex", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2QC27-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JX01-1", "uniprot_id": [ { "id": "A0A0G2JX01_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JX01", "type": "external" } ], "mass": 101247.0, "length": 904, "protein_name": "Tetratricopeptide repeat protein 7A", "gene_name": "Ttc7a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ttc7a", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 7A", "protein_names_refseq": "", "tax_id": 10116, "disease": "multiple intestinal atresia (Disease Ontology:DOID:14671); psoriasis (Disease Ontology:DOID:8893)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JX01-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE49-1", "uniprot_id": [ { "id": "D3ZE49_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE49", "type": "external" } ], "mass": 87675.0, "length": 798, "protein_name": "Trafficking protein particle complex subunit 12", "gene_name": "Trappc12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trappc12; Ttc15", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 12; Tetratricopeptide repeat protein 15", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:314013); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0051310 metaphase chromosome alignment;GO:1905342 positive regulation of protein localization to kinetochore;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZE49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAD9-1", "uniprot_id": [ { "id": "D3ZAD9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAD9", "type": "external" } ], "mass": 117906.0, "length": 1022, "protein_name": "NLR family, pyrin domain containing 9", "gene_name": "Nlrp9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nlrp9", "gene_names_refseq": "", "protein_names_uniprotkb": "NLR family, pyrin domain containing 9", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:292577)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0061702 canonical inflammasome complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0032741 positive regulation of interleukin-18 production;GO:0051607 defense response to virus;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAD9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JVP3-1", "uniprot_id": [ { "id": "A0A0G2JVP3_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JVP3", "type": "external" } ], "mass": 45463.0, "length": 413, "protein_name": "CD200 molecule like 1", "gene_name": "Cd200l1", "organism": "Rat", "refseq_name": "OX-2 membrane glycoprotein-like isoform X1", "refseq_ac": [ { "id": "XP_038944819", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038944819", "type": "external" } ], "gene_names_uniprotkb": "Cd200l1; LOC685767", "gene_names_refseq": "Cd200l1", "protein_names_uniprotkb": "CD200 molecule like 1", "protein_names_refseq": "OX-2 membrane glycoprotein-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:685767)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0016020 membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050776 regulation of immune response;GO:0043031 negative regulation of macrophage activation;GO:0034113 heterotypic cell-cell adhesion;GO:0150079 negative regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2JVP3-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K0J7-1", "uniprot_id": [ { "id": "A0A0G2K0J7_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K0J7", "type": "external" } ], "mass": 113330.0, "length": 1030, "protein_name": "RNA polymerase II subunit A C-terminal domain phosphatase", "gene_name": "Ctdp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctdp1", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA polymerase II subunit A C-terminal domain phosphatase; 3.1.3.16; TFIIF-associating CTD phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-112382); (R-RNO-113418); (R-RNO-674695); (R-RNO-6796648); (R-RNO-75955)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation., [UniProtKB, UniProtKB, UniProtKB]; This promotes the activity of RNA polymerase II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0030957 Tat protein binding;GO:0001096 TFIIF-class transcription factor complex binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:0051301 cell division;GO:0006470 protein dephosphorylation;GO:0010458 exit from mitosis;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2K0J7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZ88-1", "uniprot_id": [ { "id": "A0A0G2JZ88_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZ88", "type": "external" } ], "mass": 192411.0, "length": 1770, "protein_name": "KIAA1671 homolog", "gene_name": "Kiaa1671", "organism": "Rat", "refseq_name": "uncharacterized protein KIAA1671 homolog", "refseq_ac": [ { "id": "NP_001389401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389401", "type": "external" } ], "gene_names_uniprotkb": "Kiaa1671; RGD1306556", "gene_names_refseq": "Kiaa1671; RGD1306556; RGD1560125", "protein_names_uniprotkb": "KIAA1671 homolog", "protein_names_refseq": "uncharacterized protein KIAA1671 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288744)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JZ88-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXT8-1", "uniprot_id": [ { "id": "A0A0G2JXT8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXT8", "type": "external" } ], "mass": 277844.0, "length": 2602, "protein_name": "Filamin B", "gene_name": "Flnb", "organism": "Rat", "refseq_name": "filamin-B isoform 1", "refseq_ac": [ { "id": "NP_001418475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418475", "type": "external" } ], "gene_names_uniprotkb": "Flnb", "gene_names_refseq": "Flnb", "protein_names_uniprotkb": "Filamin B", "protein_names_refseq": "filamin B, beta; filamin, beta; filamin-B isoform 1; filamin-B-like", "tax_id": 10116, "disease": "atelosteogenesis (Disease Ontology:DOID:0050648); Boomerang dysplasia (Disease Ontology:DOID:0050680); spinal disease (Disease Ontology:DOID:0060564); bone development disease (Disease Ontology:DOID:0080006); myofibrillar myopathy 5 (Disease Ontology:DOID:0080096); spondylocarpotarsal synostosis syndrome (Disease Ontology:DOID:0090116); distal myopathy 4 (Disease Ontology:DOID:0111190); clubfoot (Disease Ontology:DOID:11836); Larsen syndrome (Disease Ontology:DOID:14764); osteochondrodysplasia (Disease Ontology:DOID:2256); myopathy (Disease Ontology:DOID:423); cleft palate (Disease Ontology:DOID:674)", "pathway": " (rno:306204); (R-RNO-1169408)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0003334 keratinocyte development;GO:0003382 epithelial cell morphogenesis;GO:0071346 cellular response to type II interferon;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JXT8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MIV5-1", "uniprot_id": [ { "id": "A0A096MIV5_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MIV5", "type": "external" } ], "mass": 71656.0, "length": 627, "protein_name": "ATP-binding cassette sub-family F member 2", "gene_name": "Abcf2", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family F member 2 isoform 1", "refseq_ac": [ { "id": "NP_001385766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385766", "type": "external" } ], "gene_names_uniprotkb": "Abcf2", "gene_names_refseq": "Abcf2", "protein_names_uniprotkb": "ATP-binding cassette sub-family F member 2", "protein_names_refseq": "ATP-binding cassette sub-family F member 2 isoform 1; ATP-binding cassette sub-family F member 2; ATP-binding cassette, sub-family F (GCN20), member 2; ATP-binding cassette, subfamily F (GCN20), member 2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MIV5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K8S0-1", "uniprot_id": [ { "id": "A0A0G2K8S0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K8S0", "type": "external" } ], "mass": 86841.0, "length": 783, "protein_name": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "gene_name": "Pdxdc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdxdc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pyridoxal-dependent decarboxylase domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:304721)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005794 Golgi apparatus", "go_biological_process": "GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2K8S0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K2S5-1", "uniprot_id": [ { "id": "A0A0G2K2S5_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K2S5", "type": "external" } ], "mass": 96307.0, "length": 853, "protein_name": "Dual specificity protein kinase TTK", "gene_name": "Ttk", "organism": "Rat", "refseq_name": "dual specificity protein kinase TTK isoform X3", "refseq_ac": [ { "id": "XP_006243524", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006243524", "type": "external" } ], "gene_names_uniprotkb": "Ttk", "gene_names_refseq": "Mps1; 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Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. 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"external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:1901991 negative regulation of mitotic cell cycle phase transition;GO:0098813 nuclear chromosome segregation;GO:0016321 female meiosis chromosome segregation;GO:0033316 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"protein_names_uniprotkb": "Leucine rich repeat containing 69", "protein_names_refseq": "leucine-rich repeat-containing protein 69 isoform 1; leucine-rich repeat-containing protein 69", "tax_id": 10116, "disease": "", "pathway": " (rno:500415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0016281 eukaryotic translation initiation factor 4F complex", "go_biological_process": "GO:0006508 proteolysis;GO:0035556 intracellular signal transduction;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1W2Q6P1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZR0-1", "uniprot_id": [ { "id": "A0A0G2JZR0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZR0", "type": "external" } ], "mass": 90401.0, "length": 798, "protein_name": "Spire-type actin nucleation factor 1", "gene_name": "Spire1", "organism": "Rat", "refseq_name": "protein spire homolog 1 isoform X1", "refseq_ac": [ { "id": "XP_006254922", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254922", "type": "external" } ], "gene_names_uniprotkb": "Spire1", "gene_names_refseq": "Spire1", "protein_names_uniprotkb": "Spire-type actin nucleation factor 1", "protein_names_refseq": "protein spire homolog 1 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:307348)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0045010 actin nucleation;GO:0030036 actin cytoskeleton organization;GO:0060996 dendritic spine development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JZR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1M7-1", "uniprot_id": [ { "id": "NMD3A_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1M7", "type": "external" } ], "mass": 127607.0, "length": 1135, "protein_name": "Glutamate receptor ionotropic, NMDA 3A", "gene_name": "Grin3a", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 3A isoform 2 precursor", "refseq_ac": [ { "id": "NP_001185512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185512", "type": "external" } ], "gene_names_uniprotkb": "Grin3a", "gene_names_refseq": "GluN3A; Grin3a; NR3; chi-1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 3A; GluN3A; Glutamate receptor chi-1; N-methyl-D-aspartate receptor subtype 3A; N-methyl-D-aspartate receptor; NMDAR-L1; NMDAR-L; NMDAR3A; NR3A", "protein_names_refseq": "N-methyl-D-aspartate receptor subtype 3A; NMDAR-L1; NMDAR-L; NMDAR3A; NR3 chi-1; NR3A; glutamate [NMDA] receptor subunit 3A; glutamate receptor chi-1; glutamate receptor ionotropic, NMDA 3A isoform 2 precursor; glutamate receptor ionotropic, NMDA 3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A", "tax_id": 10116, "disease": "", "pathway": " (rno:191573); (R-RNO-9609736)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11160393;11588171;11823786;11929923;12391275;18003876;18636091;23972471;24297929;25009255;32393578;35475675;7472412;7472413;9891978", "class_list": "", "function": "Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (PubMed:11160393, PubMed:11823786, PubMed:11929923, PubMed:18003876). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (PubMed:25009255). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (PubMed:11929923). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:11823786). GluN3A subunit also binds D-serine (PubMed:18636091). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:11160393, PubMed:11929923). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (PubMed:24297929)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GluN3 subunit expression correlates with increased vulnerability of hippocampus and entorhinal cortex to neurodegeneration in a model of temporal lobe epilepsy., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]; The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "O09098;O09155;Q62800;Q63268;Q9Z2H0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0051721 protein phosphatase 2A binding;GO:0004970 glutamate-gated receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0045471 response to ethanol;GO:0006816 calcium ion transport;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R1M7-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYN8-1", "uniprot_id": [ { "id": "HRH3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYN8", "type": "external" } ], "mass": 48588.0, "length": 445, "protein_name": "Histamine H3 receptor", "gene_name": "Hrh3", "organism": "Rat", "refseq_name": "histamine H3 receptor isoform H3B", "refseq_ac": [ { "id": "NP_001257493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257493", "type": "external" } ], "gene_names_uniprotkb": "Hrh3", "gene_names_refseq": "Hrh3", "protein_names_uniprotkb": "Histamine H3 receptor; H3R; HH3R", "protein_names_refseq": "H3R; HH3R; histamine H3 receptor isoform H3B; histamine H3 receptor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); amnestic disorder (Disease Ontology:DOID:10914); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:85268); (R-RNO-390650)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10347254;10869375;11130725;22356432;28964277;32211996;33068216", "class_list": "", "function": "Finsings show that short, but not long, isoforms fulfill the function of autoreceptor and thereby confirm the hypothesis that H3 receptor isoforms have distinct functional roles in the brain, [RefSeq, PubMed]; Histamine H3 Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at CaV2.1 (P/Q-Type) Calcium Channels and GIRK (KIR3) Potassium Channels., [RefSeq, PubMed]; Histamine H3 Receptors Expressed in Ventral Horns Modulate Spinal Motor Output., [RefSeq, PubMed]; Indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission., [RefSeq, PubMed]; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist)., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYN6;Q9QYN7;Q9QYN9", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004969 histamine receptor activity;GO:1901363 heterocyclic compound binding;GO:0043176 amine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007194 negative regulation of adenylate cyclase activity;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QYN8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYW1-1", "uniprot_id": [ { "id": "KCNN4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYW1", "type": "external" } ], "mass": 47767.0, "length": 425, "protein_name": "Intermediate conductance calcium-activated potassium channel protein 4", "gene_name": "Kcnn4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnn4; Ik1; Sk4; Smik", "gene_names_refseq": "", "protein_names_uniprotkb": "Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCa4; SKCa 4; SKCa4; SMIK; Smooth muscle intermediate-conductance KCa channel; rIK1; rSK4", "protein_names_refseq": "", "tax_id": 10116, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); dehydrated hereditary stomatocytosis 2 (Disease Ontology:DOID:0111577); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:65206); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10519135;10532960", "class_list": "", "function": "Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10532960). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:10532960). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Controls calcium influx during vascular contractility by being responsible of membrane hyperpolarization induced by vasoactive factors in proliferative vascular smooth muscle cell types (PubMed:10532960). Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium influx promoting sustained calcium entry in response to stimulation with chemotactic peptides. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (By similarity). Plays a role in the late stages of EGF-induced macropinocytosis through activation by PI(3)P (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R198;Q9WVA5", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042803 protein homodimerization activity;GO:0005267 potassium channel activity;GO:0019903 protein phosphatase binding;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0030322 stabilization of membrane potential;GO:0046541 saliva secretion;GO:0051289 protein homotetramerization;GO:1903980 positive regulation of microglial cell activation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM6-1", "uniprot_id": [ { "id": "NCKX1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZM6", "type": "external" } ], "mass": 129981.0, "length": 1181, "protein_name": "Sodium/potassium/calcium exchanger 1", "gene_name": "Slc24a1", "organism": "Rat", "refseq_name": "sodium/potassium/calcium exchanger 1", "refseq_ac": [ { "id": "NP_064475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064475", "type": "external" } ], "gene_names_uniprotkb": "Slc24a1; Nckx1", "gene_names_refseq": "Nckx1; Slc24a1", "protein_names_uniprotkb": "Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger; Solute carrier family 24 member 1", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 1; retinal Na/Ca,K exchanger; retinal rod Na-Ca+K exchanger; sodium/calcium/potassium exchanger; sodium/potassium/calcium exchanger 1; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1", "tax_id": 10116, "disease": "congenital stationary night blindness 1D (Disease Ontology:DOID:0110868)", "pathway": " (rno:56814); (R-RNO-425561)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10751314;12502535", "class_list": "", "function": "Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Differential expression in the rat brain, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q62932", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0007601 visual perception;GO:0035725 sodium ion transmembrane transport;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZM6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Y9-1", "uniprot_id": [ { "id": "KLOT_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Y9", "type": "external" } ], "mass": 116800.0, "length": 1014, "protein_name": "Klotho", "gene_name": "Kl", "organism": "Rat", "refseq_name": "klotho precursor", "refseq_ac": [ { "id": "NP_112626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112626", "type": "external" } ], "gene_names_uniprotkb": "Kl", "gene_names_refseq": "Kl", "protein_names_uniprotkb": "Klotho; 3.2.1.31", "protein_names_refseq": "klotho precursor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); hyperphosphatemic familial tumoral calcinosis (Disease Ontology:DOID:0111063); retinitis pigmentosa (Disease Ontology:DOID:10584); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); secondary hyperparathyroidism (Disease Ontology:DOID:12466); spondylosis (Disease Ontology:DOID:2247); coronary artery disease (Disease Ontology:DOID:3393); intracranial embolism (Disease Ontology:DOID:4372); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:83504); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190374); (R-RNO-5654219); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654726); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 12, "publication_count": 12, "publication_id_list": "10631108;10892340;11967236;12965205;17992255;37793463;38330925;38589756;38904464;39264079;9731228;9791011", "class_list": "glycogene;glycosylhydrolase", "function": "ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS., [RefSeq, PubMed]; ER stress modulated Klotho restoration: A prophylactic therapeutic strategy against acute kidney injury-diabetes comorbidity., [RefSeq, PubMed]; Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys., [RefSeq, PubMed]; Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By similarity). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (By similarity)., [UniProtKB, UniProtKB]; Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway., [RefSeq, PubMed]; Overexpression of alpha-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology., [RefSeq, PubMed]; The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" } ], "go_molecular_function": "GO:0017134 fibroblast growth factor binding;GO:0004566 beta-glucuronidase activity;GO:0005104 fibroblast growth factor receptor binding;GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds", "go_cellular_component": "GO:0005576 extracellular region;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0005975 carbohydrate metabolic process;GO:0006112 energy reserve metabolic process;GO:0014823 response to activity;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z2Y9-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R172-1", "uniprot_id": [ { "id": "NOTC3_RAT", "url": "https://www.uniprot.org/uniprot/Q9R172", "type": "external" } ], "mass": 244301.0, "length": 2319, "protein_name": "Neurogenic locus notch homolog protein 3", "gene_name": "Notch3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Notch3", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 3; Notch 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 (Disease Ontology:DOID:0061227); familial partial lipodystrophy type 1 (Disease Ontology:DOID:0070207); infantile myofibromatosis 2 (Disease Ontology:DOID:0070667); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 (Disease Ontology:DOID:0111035); lateral meningocele syndrome (Disease Ontology:DOID:0111343); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); brain cancer (Disease Ontology:DOID:1319); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:56761); (R-RNO-1912420); (R-RNO-350054); (R-RNO-9013507); (R-RNO-9017802)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11182080;11438922", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Acts instructively to control the cell fate determination of CNS multipotent progenitor cells, resulting in astroglial induction and neuron/oligodendrocyte suppression., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0030900 forebrain development;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R172-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1T9-1", "uniprot_id": [ { "id": "KCNH4_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1T9", "type": "external" } ], "mass": 111404.0, "length": 1017, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH4", "gene_name": "Kcnh4", "organism": "Rat", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH4", "refseq_ac": [ { "id": "NP_446082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446082", "type": "external" } ], "gene_names_uniprotkb": "Kcnh4; Elk1; Elk3", "gene_names_refseq": "Bec2; Kcnh4", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH4; BEC2; Brain-specific eag-like channel 2; ELK channel 1; Ether-a-go-go-like potassium channel 1; Potassium voltage-gated channel subfamily H member 4; Voltage-gated potassium channel subunit Kv12.3; rElk1", "protein_names_refseq": "ELK channel 1; brain-specific eag-like channel 2; ether-a-go-go-like potassium channel 1; potassium channel, voltage gated eag related subfamily H, member 4; potassium voltage-gated channel, subfamily H (eag-related), member 4; rElk1; voltage-gated delayed rectifier potassium channel KCNH4; voltage-gated potassium channel subunit Kv12.3", "tax_id": 10116, "disease": "", "pathway": " (rno:114032); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10455180;11425889;9824707", "class_list": "", "function": "Pore-forming (alpha) subunit of a voltage-gated delayed rectifier (PubMed:9824707). Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation (PubMed:9824707)., [UniProtKB, PubMed]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O89048", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R1T9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ58-1", "uniprot_id": [ { "id": "HSPB3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZ58", "type": "external" } ], "mass": 17210.0, "length": 152, "protein_name": "Heat shock protein beta-3", "gene_name": "Hspb3", "organism": "Rat", "refseq_name": "heat shock protein beta-3", "refseq_ac": [ { "id": "NP_113938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113938", "type": "external" } ], "gene_names_uniprotkb": "Hspb3", "gene_names_refseq": "Hspb3", "protein_names_uniprotkb": "Heat shock protein beta-3; HspB3", "protein_names_refseq": "heat shock 27kD protein 3; heat shock 27kD protein family, member 3; heat shock 27kDa protein 3; heat shock protein 3; heat shock protein B3; heat shock protein beta-3", "tax_id": 10116, "disease": "autosomal dominant distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111209)", "pathway": " (rno:78951)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19715703", "class_list": "", "function": "Despite the high level of sequence homology within the small heat-shock proteins (sHSPs) family the biochemical properties of the HSPB2/B3 complex are distinctly different from those of other sHSPs., [RefSeq, PubMed]; Inhibitor of actin polymerization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZ58-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Q3-1", "uniprot_id": [ { "id": "HYAL2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Q3", "type": "external" } ], "mass": 53999.0, "length": 473, "protein_name": "Hyaluronidase-2", "gene_name": "Hyal2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hyal2", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronidase-2; 3.2.1.35; Hyal-2; Hyaluronoglucosaminidase-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (R-RNO-2142845); (R-RNO-2160916)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0001618 virus receptor activity;GO:0030971 receptor tyrosine kinase binding;GO:0050431 transforming growth factor beta binding;GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0010764 negative regulation of fibroblast migration;GO:0071493 cellular response to UV-B;GO:0042117 monocyte activation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9Z2Q3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0K5-1", "uniprot_id": [ { "id": "IGSF6_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0K5", "type": "external" } ], "mass": 26433.0, "length": 238, "protein_name": "Immunoglobulin superfamily member 6", "gene_name": "Igsf6", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 6 precursor", "refseq_ac": [ { "id": "NP_598226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598226", "type": "external" } ], "gene_names_uniprotkb": "Igsf6; Dora", "gene_names_refseq": "DORA; Igsf6", "protein_names_uniprotkb": "Immunoglobulin superfamily member 6; IgSF6; Protein DORA", "protein_names_refseq": "immunoglobulin superfamily member 6 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:171064)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9809579", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z0K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYU2-1", "uniprot_id": [ { "id": "EFTS_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYU2", "type": "external" } ], "mass": 35178.0, "length": 324, "protein_name": "Elongation factor Ts, mitochondrial", "gene_name": "Tsfm", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tsfm; TSFM", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation factor Ts, mitochondrial; 2A3-2; EF-TsMt; EF-Ts", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 3 (Disease Ontology:DOID:0111486)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10397682", "class_list": "", "function": "Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Participates in mitochondrial translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0070013 intracellular organelle lumen", "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYU2-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYU3-1", "uniprot_id": [ { "id": "KCNG2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYU3", "type": "external" } ], "mass": 52536.0, "length": 480, "protein_name": "Voltage-gated potassium channel regulatory subunit KCNG2", "gene_name": "Kcng2", "organism": "Rat", "refseq_name": "voltage-gated potassium channel regulatory subunit KCNG2", "refseq_ac": [ { "id": "NP_001100842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100842", "type": "external" } ], "gene_names_uniprotkb": "Kcng2", "gene_names_refseq": "Kcng2; Kv6.2", "protein_names_uniprotkb": "Voltage-gated potassium channel regulatory subunit KCNG2; Cardiac potassium channel subunit; Potassium voltage-gated channel subfamily G member 2; Voltage-gated potassium channel subunit Kv6.2", "protein_names_refseq": "cardiac potassium channel subunit (Kv6.2); potassium channel, voltage gated modifier subfamily G, member 2; potassium voltage-gated channel, subfamily G, member 2; voltage-gated potassium channel regulatory subunit KCNG2; voltage-gated potassium channel subunit Kv6.2", "tax_id": 10116, "disease": "", "pathway": " (rno:307234); (R-RNO-1296072); (R-RNO-381676)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10551266", "class_list": "", "function": "Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, can modulate the kinetics and conductance-voltage relationship (PubMed:10551266). Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (PubMed:10551266). Potassium channel subunit that does not form functional channels by itself (PubMed:10551266)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0043266 regulation of potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYU7-1", "uniprot_id": [ { "id": "NSA2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYU7", "type": "external" } ], "mass": 30038.0, "length": 260, "protein_name": "Ribosome biogenesis protein NSA2 homolog", "gene_name": "Nsa2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nsa2; Cdk105; Tinp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome biogenesis protein NSA2 homolog; Protein CDK105; TGF-beta-inducible nuclear protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10783328", "class_list": "", "function": "Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WV49", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0000460 maturation of 5.8S rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYU7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZ86-1", "uniprot_id": [ { "id": "NOP58_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZ86", "type": "external" } ], "mass": 60071.0, "length": 534, "protein_name": "Nucleolar protein 58", "gene_name": "Nop58", "organism": "Rat", "refseq_name": "nucleolar protein 58", "refseq_ac": [ { "id": "NP_068522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068522", "type": "external" } ], "gene_names_uniprotkb": "Nop58; Nap65; Nol5; Nop5", "gene_names_refseq": "Nap65; Nol5; Nop58", "protein_names_uniprotkb": "Nucleolar protein 58; Nopp140-associated protein of 65 kDa; Nucleolar protein 5", "protein_names_refseq": "NOP58 ribonucleoprotein homolog; Nopp140 associated protein; nopp140-associated protein of 65 kDa; nucleolar protein 58; nucleolar protein 5; nucleolar protein NOP58", "tax_id": 10116, "disease": "", "pathway": " (rno:60373); (R-RNO-4570464); (R-RNO-6791226)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10679015;22673903", "class_list": "", "function": "Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88525", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0030515 snoRNA binding;GO:0001094 TFIID-class transcription factor complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:0048254 snoRNA localization;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZ86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZC5-1", "uniprot_id": [ { "id": "GRB7_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZC5", "type": "external" } ], "mass": 59889.0, "length": 535, "protein_name": "Growth factor receptor-bound protein 7", "gene_name": "Grb7", "organism": "Rat", "refseq_name": "growth factor receptor-bound protein 7", "refseq_ac": [ { "id": "NP_445855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445855", "type": "external" } ], "gene_names_uniprotkb": "Grb7", "gene_names_refseq": "Grb7", "protein_names_uniprotkb": "Growth factor receptor-bound protein 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein", "protein_names_refseq": "GRB7 adapter protein; epidermal growth factor receptor GRB-7; growth factor receptor binding protein GRB7; growth factor receptor-bound protein 7", "tax_id": 10116, "disease": "gastrointestinal carcinoma (Disease Ontology:DOID:0050922); esophageal carcinoma (Disease Ontology:DOID:1107); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophagus adenocarcinoma (Disease Ontology:DOID:4914); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:84427); (R-RNO-1306955); (R-RNO-1433557); (R-RNO-186763); (R-RNO-210993); (R-RNO-8853659); (R-RNO-9696273)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10803466;20142421;22673903", "class_list": "", "function": "Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity)., [UniProtKB]; EGF also activates focal adhesion kinase in the cytoplasm to rephosphorylate Grb7, releasing KOR mRNA for active translation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0042995 cell projection;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0017148 negative regulation of translation;GO:0034063 stress granule assembly;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZC5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZK5-1", "uniprot_id": [ { "id": "HTRA1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZK5", "type": "external" } ], "mass": 51330.0, "length": 480, "protein_name": "Serine protease HTRA1", "gene_name": "Htra1", "organism": "Rat", "refseq_name": "serine protease HTRA1 precursor", "refseq_ac": [ { "id": "NP_113909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113909", "type": "external" } ], "gene_names_uniprotkb": "Htra1; Htra; Prss11", "gene_names_refseq": "Htra1; Prss11", "protein_names_uniprotkb": "Serine protease HTRA1; 3.4.21.-; High-temperature requirement A serine peptidase 1; Serine protease 11", "protein_names_refseq": "high-temperature requirement A serine peptidase 1; protease serine 11; protease, serine, 11 (Igf binding); serine protease 11; serine protease HTRA1 precursor; serine protease HTRA1", "tax_id": 10116, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:65164); (R-RNO-1474228)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "36042379", "class_list": "", "function": "Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1. Publication Status: Online-Only, [RefSeq, PubMed]; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0060718 chorionic trophoblast cell differentiation;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0001890 placenta development;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Q2-1", "uniprot_id": [ { "id": "LT4R1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0Q2", "type": "external" } ], "mass": 37931.0, "length": 351, "protein_name": "Leukotriene B4 receptor 1", "gene_name": "Ltb4r", "organism": "Rat", "refseq_name": "leukotriene B4 receptor 1", "refseq_ac": [ { "id": "NP_067688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067688", "type": "external" } ], "gene_names_uniprotkb": "Ltb4r; Blt", "gene_names_refseq": "BLT-1; BLT1; LTB4-R1; Ltb4r1; Ltb4r", "protein_names_uniprotkb": "Leukotriene B4 receptor 1; LTB4-R 1; LTB4-R1", "protein_names_refseq": "leukotriene B4 receptor 1", "tax_id": 10116, "disease": "carotid artery disease (Disease Ontology:DOID:3407)", "pathway": " (rno:59264); (R-RNO-391906); (R-RNO-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10471406;15561704;19657115;20403205;21189570;27725151", "class_list": "", "function": "BLT1 and BLT2 were involved in synovial cell proliferation., [RefSeq, PubMed]; FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions., [RefSeq, PubMed]; LTB4 down-regulates airway contraction and inflammation through activation of the hypothalamic-pituitary-adrenal axis via its BLT1 receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation-independent mechanisms regulate beta-arrestin association and internalization of BLT1, [RefSeq, PubMed]; Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response., [UniProtKB]; Study verified that both BLT1 mRNA and BLT1 protein expressions were markedly increased after subarachnoid hemorrhage and elevated BLT1 expressions were mainly found in neurons, microglia and endothelial cells rather than astrocytes. We also demonstrated that there a significant positive correlation between BLT1 and nuclear p65 protein expressions in the same specific time course., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0001632 leukotriene B4 receptor activity;GO:0004974 leukotriene receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R0Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0U1-1", "uniprot_id": [ { "id": "IP6K2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0U1", "type": "external" } ], "mass": 49164.0, "length": 425, "protein_name": "Inositol hexakisphosphate kinase 2", "gene_name": "Ip6k2", "organism": "Rat", "refseq_name": "inositol hexakisphosphate kinase 2", "refseq_ac": [ { "id": "NP_067692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067692", "type": "external" } ], "gene_names_uniprotkb": "Ip6k2; Ihpk2; Pius", "gene_names_refseq": "Ihpk2; Ip6k2; Pius", "protein_names_uniprotkb": "Inositol hexakisphosphate kinase 2; 2.7.4.-; InsP6 kinase 2; P(i)-uptake stimulator; PiUS", "protein_names_refseq": "InsP6 kinase 2; P(i)-uptake stimulator; inositol hexakisphosphate kinase 2; inositol hexaphosphate kinase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:59268); (R-RNO-1855191)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10527952;29393594", "class_list": "", "function": "Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIU6", "ec_number_list": [ { "id": "2.7.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.21", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.-", "type": "external" } ], "go_molecular_function": "GO:0000828 inositol hexakisphosphate kinase activity;GO:0000832 inositol hexakisphosphate 5-kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0097243 flavonoid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043065 positive regulation of apoptotic process;GO:0050821 protein stabilization;GO:0030308 negative regulation of cell growth;GO:0071902 positive regulation of protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R0U1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1A7-1", "uniprot_id": [ { "id": "NR1I2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1A7", "type": "external" } ], "mass": 49660.0, "length": 431, "protein_name": "Nuclear receptor subfamily 1 group I member 2", "gene_name": "Nr1i2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 1 group I member 2", "refseq_ac": [ { "id": "NP_443212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443212", "type": "external" } ], "gene_names_uniprotkb": "Nr1i2; Pxr", "gene_names_refseq": "Nr1i2; PXR", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PXR; Pregnane X receptor", "protein_names_refseq": "nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; orphan nuclear receptor PXR; pregnane X receptor (nuclear receptor sub family 1, group I, member 2)", "tax_id": 10116, "disease": "cholestasis (Disease Ontology:DOID:13580); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:84385); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10415106;30132884;31955533;32205367;34226610", "class_list": "", "function": "Acute hypoxia at high altitude can affect the expression of nuclear receptor PXR in rat liver, [RefSeq, PubMed]; High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1., [UniProtKB, UniProtKB]; PXR significantly increased neointimal formation in balloon-injured rat carotid arteries. PXR increased smooth muscle cell proliferation and migration via the induction of phosphorylation of ERK1/2 and p38 MAPK., [RefSeq, PubMed]; Phosphorylation Modulates the Coregulatory Protein Exchange of the Nuclear Receptor Pregnane X Receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9R1A7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R261-1", "uniprot_id": [ { "id": "PD2R_RAT", "url": "https://www.uniprot.org/uniprot/Q9R261", "type": "external" } ], "mass": 39769.0, "length": 357, "protein_name": "Prostaglandin D2 receptor", "gene_name": "Ptgdr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptgdr", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498475); (R-RNO-391908)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10448933;6302737", "class_list": "", "function": "Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (PubMed:10448933). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004955 prostaglandin receptor activity;GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R261-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTV5-1", "uniprot_id": [ { "id": "PSMD9_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTV5", "type": "external" } ], "mass": 24829.0, "length": 222, "protein_name": "26S proteasome non-ATPase regulatory subunit 9", "gene_name": "Psmd9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psmd9", "gene_names_refseq": "", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27; Transactivating protein Bridge-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:161475)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10567574;22673903", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0046676 negative regulation of insulin secretion;GO:0070682 proteasome regulatory particle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WTV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV41-1", "uniprot_id": [ { "id": "INSL6_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV41", "type": "external" } ], "mass": 21442.0, "length": 188, "protein_name": "Insulin-like peptide INSL6", "gene_name": "Insl6", "organism": "Rat", "refseq_name": "insulin-like peptide INSL6 precursor", "refseq_ac": [ { "id": "NP_072105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072105", "type": "external" } ], "gene_names_uniprotkb": "Insl6", "gene_names_refseq": "Insl6", "protein_names_uniprotkb": "Insulin-like peptide INSL6; Insulin-like peptide 6", "protein_names_refseq": "insulin-like peptide 6; insulin-like peptide INSL6 precursor; insulin-like peptide INSL6", "tax_id": 10116, "disease": "", "pathway": " (rno:50546)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10819760;29393594", "class_list": "", "function": "May have a role in sperm development and fertilization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0043066 negative regulation of apoptotic process;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WV41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV50-1", "uniprot_id": [ { "id": "NIP7_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV50", "type": "external" } ], "mass": 20432.0, "length": 180, "protein_name": "60S ribosome subunit biogenesis protein NIP7 homolog", "gene_name": "Nip7", "organism": "Rat", "refseq_name": "60S ribosome subunit biogenesis protein NIP7 homolog", "refseq_ac": [ { "id": "NP_620202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620202", "type": "external" } ], "gene_names_uniprotkb": "Nip7; Peachy", "gene_names_refseq": "CGI-37; Nip7p; Nip7; pEachy", "protein_names_uniprotkb": "60S ribosome subunit biogenesis protein NIP7 homolog; Nucleolar pre-rRNA processing protein NIP7; PEachy; kDa93", "protein_names_refseq": "60S ribosome subunit biogenesis protein NIP7 homolog; NIP7, nucleolar pre-rRNA processing protein; Saccharomyces cerevisiae Nip7p homolog; kDa93; nuclear import 7 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:192180); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJL7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WV50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVA9-1", "uniprot_id": [ { "id": "NPFF_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVA9", "type": "external" } ], "mass": 13152.0, "length": 114, "protein_name": "Pro-FMRFamide-related neuropeptide FF", "gene_name": "Npff", "organism": "Rat", "refseq_name": "pro-FMRFamide-related neuropeptide FF preproprotein", "refseq_ac": [ { "id": "NP_072108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072108", "type": "external" } ], "gene_names_uniprotkb": "Npff", "gene_names_refseq": "Npff", "protein_names_uniprotkb": "Pro-FMRFamide-related neuropeptide FF; FMRFamide-related peptides", "protein_names_refseq": "FMRFamide-related peptides; pain modulating peptide precursor; pro-FMRFamide-related neuropeptide FF preproprotein; pro-FMRFamide-related neuropeptide FF", "tax_id": 10116, "disease": "", "pathway": " (rno:60337); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10220558;11587714;11984823;12668052;22342307;24316399;25247577;28825666;33255594", "class_list": "", "function": "Insulin-degrading enzyme is able to degrade specific amino acid sequences present in the neuropeptide pro-NPFFA (NPFF precursor), generating some cryptic peptides that are also observed after incubation with rat brain cortex homogenate. Publication Status: Online-Only, [RefSeq, PubMed]; Intracerebroventricular Neuropeptide FF Diminishes the Number of Apneas and Cardiovascular Effects Produced by Opioid Receptors' Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF and SF potentiate and sensitize ASIC2 and ASIC3 channels., [UniProtKB, PubMed, PubMed]; NPFF is capable of up-regulating its own gene expression in the solitary nucleus. NPFF may play a homeostatic role in response to specific cardiovascular challenges, such as hypotension., [RefSeq, PubMed]; NPSF may play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the hypothalamic-pituitary-adrenal axis, through the release of corticotropin releasing hormone., [RefSeq, PubMed]; The ASIC are tonically active in the vestibular-afferent neurons and modulated by RFamide-like peptides, [RefSeq, PubMed]; We demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0160041 neuropeptide activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0043679 axon terminus", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0021510 spinal cord development;GO:0045777 positive regulation of blood pressure;GO:0060079 excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WVA9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVM4-1", "uniprot_id": [ { "id": "ICMT_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVM4", "type": "external" } ], "mass": 31812.0, "length": 284, "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "Icmt", "organism": "Rat", "refseq_name": "protein-S-isoprenylcysteine O-methyltransferase", "refseq_ac": [ { "id": "NP_579844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579844", "type": "external" } ], "gene_names_uniprotkb": "Icmt", "gene_names_refseq": "Icmt; fcmt", "protein_names_uniprotkb": "Protein-S-isoprenylcysteine O-methyltransferase; 2.1.1.100; FCMT; Farnesyl cysteine carboxyl methyltransferase; Isoprenylcysteine carboxylmethyltransferase; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl methyltransferase; pcCMT", "protein_names_refseq": "PPMT; farnesyl cysteine carboxyl methyltransferase; pcCMT; prenylated protein carboxyl methyltransferase; prenylcysteine carboxyl methlytransferase; prenylcysteine carboxyl methyltransferase; protein-S-isoprenylcysteine O-methyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:170818); (R-RNO-163841); (R-RNO-9648002)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12631708;21346419", "class_list": "", "function": "Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues., [UniProtKB, UniProtKB]; Data suggest that ICMT regulates glucose-induced Rac1 activation, generation of reactive oxygen species and insulin secretion in pancreatic beta-cells, [RefSeq, PubMed]; Findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase methylation and activation and its downstream antiapoptotic signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7G5", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.100", "type": "external" } ], "go_molecular_function": "GO:0008140 cAMP response element binding protein binding;GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0008284 positive regulation of cell population proliferation;GO:0050905 neuromuscular process;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WVM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0W0-1", "uniprot_id": [ { "id": "GLP2R_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0W0", "type": "external" } ], "mass": 63102.0, "length": 550, "protein_name": "Glucagon-like peptide 2 receptor", "gene_name": "Glp2r", "organism": "Rat", "refseq_name": "glucagon-like peptide 2 receptor", "refseq_ac": [ { "id": "NP_068620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068620", "type": "external" } ], "gene_names_uniprotkb": "Glp2r", "gene_names_refseq": "Glp2r", "protein_names_uniprotkb": "Glucagon-like peptide 2 receptor; GLP-2 receptor; GLP-2-R; GLP-2R", "protein_names_refseq": "GLP-2 receptor; GLP-2-R; GLP-2R; glucagon-like peptide 2 receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:60432); (R-RNO-420092)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12960094;15059959;15544847;17676310;19672727;20620343;25748021;30452417;9990065", "class_list": "", "function": "Activation of the endogenous rat mucosal GLP-2 receptor is linked to activation of a cAMP/protein kinase A-dependent, growth-promoting pathway in vitro., [RefSeq, PubMed]; Downregulation of IGF-1R and IGF-2R gene expression may interfere with normal alveologenesis causing pulmonary hypoplasia in the nitrofen-induced CDH model., [RefSeq, PubMed]; GLP-2 and several growth factors show synergistic effects on the proliferation of rat astrocytes, a process in which an enhanced expression of GLP-2R and IGF-IR may be involved, [RefSeq, PubMed]; GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth, [RefSeq, PubMed]; GLP2R expression in the rat jejunum quantified by quantitative real time PCR., [RefSeq, PubMed]; Glucagon-like peptide 2 stimulates glucagon secretion through GLP-2r present on the alpha cell in rats., [RefSeq, PubMed]; Our findings reveal the involvement of GLP2R via a modulation of the AKT-mTOR-p70S6K pathway in the mechanisms underlying chronic cerebral hypoperfusion-induced impairments of spatial learning and memory., [RefSeq, PubMed]; Presence of a functional GLP-2-GLP-2R axis in the developing rodent brain, [RefSeq, PubMed]; This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0004967 glucagon receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Y0-1", "uniprot_id": [ { "id": "KEG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Y0", "type": "external" } ], "mass": 34016.0, "length": 295, "protein_name": "Glycine N-acyltransferase-like protein Keg1", "gene_name": "Glyatl2; Keg1", "organism": "Rat", "refseq_name": "glycine N-acyltransferase-like protein Keg1", "refseq_ac": [ { "id": "NP_599157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599157", "type": "external" } ], "gene_names_uniprotkb": "Glyatl2; Keg1; Hp33", "gene_names_refseq": "Glyatl2; HP33; Keg1", "protein_names_uniprotkb": "Glycine N-acyltransferase-like protein Keg1; 2.3.1.13; Acyl-CoA:glycine N-acyltransferase protein Keg1; HP33; Hepatocellular carcinoma-enriched protein of 33 kDa; Kidney-expressed gene 1 protein", "protein_names_refseq": "Acyl-CoA:glycine N-acyltransferase protein Keg1; glycine N-acyltransferase-like protein Keg1; hepatocellular carcinoma-enriched protein of 33 kDa; kidney expressed gene 1; kidney-expressed gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171179)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10194414;10470852;29393594", "class_list": "", "function": "Acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68G42", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.13", "type": "external" }, { "id": "2.3.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.71", "type": "external" } ], "go_molecular_function": "GO:0043015 gamma-tubulin binding;GO:0016410 N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2Y0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z339-1", "uniprot_id": [ { "id": "GSTO1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z339", "type": "external" } ], "mass": 27669.0, "length": 241, "protein_name": "Glutathione S-transferase omega-1", "gene_name": "Gsto1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gsto1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione S-transferase omega-1; 1.20.4.2; 1.8.5.1; 2.5.1.18; GSTO 1-1; GSTO-1; Glutathione S-transferase omega 1-1; Glutathione-dependent dehydroascorbate reductase; MMA(V) reductase; Monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; SPG-R", "protein_names_refseq": "", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 6 (Disease Ontology:DOID:0060198); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (R-RNO-156581); (R-RNO-156590); (R-RNO-196836)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9786866", "class_list": "", "function": "Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Also has glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016491 oxidoreductase activity;GO:0045174 glutathione dehydrogenase (ascorbate) activity;GO:0050610 methylarsonate reductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0044297 cell body", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0042178 xenobiotic catabolic process;GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z339-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MIZ0-1", "uniprot_id": [ { "id": "A0A096MIZ0_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MIZ0", "type": "external" } ], "mass": 73462.0, "length": 662, "protein_name": "Rhophilin, Rho GTPase binding protein 1", "gene_name": "Rhpn1", "organism": "Rat", "refseq_name": "rhophilin-1 isoform X1", "refseq_ac": [ { "id": "XP_006241962", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241962", "type": "external" } ], "gene_names_uniprotkb": "Rhpn1", "gene_names_refseq": "Rhpn1", "protein_names_uniprotkb": "Rhophilin, Rho GTPase binding protein 1", "protein_names_refseq": "rhophilin-1 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:300030); (R-RNO-5666185); (R-RNO-8980692)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0007165 signal transduction;GO:0001822 kidney development;GO:0048041 focal adhesion assembly;GO:0003094 glomerular filtration;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MIZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJ36-1", "uniprot_id": [ { "id": "A0A096MJ36_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJ36", "type": "external" } ], "mass": 8952.0, "length": 88, "protein_name": "Lymphocyte antigen 6D-like", "gene_name": "LOC120093891", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC120093891", "gene_names_refseq": "", "protein_names_uniprotkb": "Lymphocyte antigen 6D-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MJ36-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJ70-1", "uniprot_id": [ { "id": "A0A096MJ70_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJ70", "type": "external" } ], "mass": 141029.0, "length": 1276, "protein_name": "[histone H3]-lysine(9) N-methyltransferase", "gene_name": "Prdm16", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase PRDM16 isoform X1", "refseq_ac": [ { "id": "XP_038967290", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038967290", "type": "external" } ], "gene_names_uniprotkb": "Prdm16", "gene_names_refseq": "Prdm16", "protein_names_uniprotkb": "[histone H3]-lysine(9) N-methyltransferase; 2.1.1.367", "protein_names_refseq": "histone-lysine N-methyltransferase PRDM16 isoform X1", "tax_id": 10116, "disease": "left ventricular noncompaction (Disease Ontology:DOID:0060480); dilated cardiomyopathy 1LL (Disease Ontology:DOID:0081157)", "pathway": " (R-RNO-3214841)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0016604 nuclear body", "go_biological_process": "GO:0043457 regulation of cellular respiration;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0050872 white fat cell differentiation;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MJ70-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MJ92-1", "uniprot_id": [ { "id": "A0A096MJ92_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MJ92", "type": "external" } ], "mass": 35364.0, "length": 314, "protein_name": "Olfactory receptor family 8 subfamily B member 35", "gene_name": "Or8b35", "organism": "Rat", "refseq_name": "olfactory receptor Olr1204", "refseq_ac": [ { "id": "NP_001000437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000437", "type": "external" } ], "gene_names_uniprotkb": "Or8b35", "gene_names_refseq": "Olr1204; Or8b35; ratchr8-39394220-39395164_ORF", "protein_names_uniprotkb": "Olfactory receptor family 8 subfamily B member 35", "protein_names_refseq": "olfactory receptor 1204; olfactory receptor Olr1204; olfactory receptor gene Olr1204", "tax_id": 10116, "disease": "", "pathway": " (rno:300529)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MJ92-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MK60-1", "uniprot_id": [ { "id": "A0A096MK60_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MK60", "type": "external" } ], "mass": 107429.0, "length": 940, "protein_name": "Schlafen family member 5", "gene_name": "Slfn5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slfn5", "gene_names_refseq": "", "protein_names_uniprotkb": "Schlafen family member 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:303377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A096MK60-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MK89-1", "uniprot_id": [ { "id": "A0A096MK89_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MK89", "type": "external" } ], "mass": 685897.0, "length": 6298, "protein_name": "Adhesion G-protein coupled receptor V1", "gene_name": "Adgrv1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adgrv1", "gene_names_refseq": "", "protein_names_uniprotkb": "Adhesion G-protein coupled receptor V1; G-protein coupled receptor 98; Very large G-protein coupled receptor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Usher syndrome type 2C (Disease Ontology:DOID:0110839); familial febrile seizures 4 (Disease Ontology:DOID:0111305); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1., [UniProtKB, UniProtKB]; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016787 hydrolase activity;GO:0005509 calcium ion binding;GO:0017022 myosin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048496 maintenance of animal organ identity;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007194 negative regulation of adenylate cyclase activity;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A096MK89-1", 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