[ { "uniprot_canonical_ac": "Q9Z214-1", "uniprot_id": [ { "id": "HOME1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z214", "type": "external" } ], "mass": 41305.0, "length": 366, "protein_name": "Homer protein homolog 1", "gene_name": "Homer1", "organism": "Rat", "refseq_name": "homer protein homolog 1", "refseq_ac": [ { "id": "NP_113895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113895", "type": "external" } ], "gene_names_uniprotkb": "Homer1; Homer; Vesl", "gene_names_refseq": "HOMER1F; Homer1; Vesl-1", "protein_names_uniprotkb": "Homer protein homolog 1; PSD-Zip45; VASP/Ena-related gene up-regulated during seizure and LTP 1; Vesl-1", "protein_names_refseq": "PSD-Zip45; VASP/Ena-related gene up-regulated during seizure and LTP 1; homer homolog 1; homer protein homolog 1; homer scaffolding protein 1; homer, neuronal immediate early gene, 1; scaffold protein", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); anxiety disorder (Disease Ontology:DOID:2030); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29546); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 25, "publication_id_list": "10433269;10798399;10851183;11118290;12054806;12810060;12887973;14528310;15034583;17584991;18683930;19345194;30021165;31369778;31404590;31891692;32013638;32756473;38843836;9069287;9257717;9727012;9808458;9808459;9824313", "class_list": "", "function": "Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins., [RefSeq, PubMed]; Homer1a protects against neuronal injury via PI3K/AKT/mTOR signaling pathway., [RefSeq, PubMed]; Kainic acid-induced status epilepticus decreases mGlu5 receptor and phase-specifically downregulates Homer1b/c expression., [RefSeq, PubMed]; Lysophosphatidic acid treatment did not alter the expression and distribution of Homer1 in cortical neurons. Knockdown of Homer1 using specific siRNA partially prevented the LPA-induced neurotoxicity and ER stress. LPA induced intracellular Ca(2+) release could be partly prevented by downregulation of Homer1., [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (PubMed:19345194). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The Effects of Antipsychotics on the Synaptic Plasticity Gene Homer1a Depend on a Combination of Their Receptor Profile, Dose, Duration of Treatment, and Brain Regions Targeted. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08567;O88800;Q9QUJ8;Q9QWN5", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0031802 type 5 metabotropic glutamate receptor binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0090279 regulation of calcium ion import;GO:0003009 skeletal muscle contraction;GO:0007613 memory;GO:0035094 response to nicotine;GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9Z214-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HLU6-1", "uniprot_id": [ { "id": "HMNL_RAT", "url": "https://www.uniprot.org/uniprot/C0HLU6", "type": "external" } ], "mass": 4338.0, "length": 38, "protein_name": "Humanin-like protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Humanin-like protein; HNr; Rattin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 8, "publication_id_list": "12154011;16619233;19623253;23996574;25360890;26116236;31214013;33764899", "class_list": "", "function": "Plays a role as a neuroprotective factor (PubMed:12154011). Protects against neuronal cell death induced by amyloid-beta peptides (PubMed:12154011). Also protects against excitotoxic cell death (PubMed:12154011). Prevents amyloid-beta peptide-induced spatial learning and memory impairments, protects against amyloid-beta peptide-induced suppression of hippocampal long-term potentiation, and inhibits amyloid-beta peptide-induced activation of STAT3 and inhibition of CASP3 (PubMed:23996574). Prevents glutamate-induced dendritic atrophy in hippocampal neurons and also prevents glutamate-induced decrease in SYP puncta number and total puncta area (PubMed:31214013). Protects anterior pituitary cells from TNF-induced apoptosis (PubMed:25360890). Plays a role in ovarian follicle development by acting as a cryoprotective factor for granulosa cells in the antral follicle (PubMed:33764899). Increases androgen production in Leydig cells and promotes Leydig cell survival by preventing apoptosis (PubMed:16619233)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:1904646 cellular response to amyloid-beta;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "C0HLU6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31424-1", "uniprot_id": [ { "id": "GRM5_RAT", "url": "https://www.uniprot.org/uniprot/P31424", "type": "external" } ], "mass": 131885.0, "length": 1203, "protein_name": "Metabotropic glutamate receptor 5", "gene_name": "Grm5", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_058708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058708", "type": "external" } ], "gene_names_uniprotkb": "Grm5; Gprc1e; Mglur5", "gene_names_refseq": "Grm5; mGluR5; mGlur5", "protein_names_uniprotkb": "Metabotropic glutamate receptor 5; mGluR5", "protein_names_refseq": "glutamate receptor, metabotropic 5; metabotropic glutamate receptor (mGluR5); metabotropic glutamate receptor 5 isoform 2 precursor; metabotropic glutamate receptor 5b; metabotropic glutamate receptor 5", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); alcoholic neuropathy (Disease Ontology:DOID:14183); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); skin squamous cell carcinoma (Disease Ontology:DOID:3151); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24418); (R-RNO-416476); (R-RNO-420499); (R-RNO-6794361)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10469171;10798399;11850456;1320017;19694902;20007903;21795692;22673903;35396501;36383609;36725696;37487948;38843836;39107945;7688218;9808459", "class_list": "", "function": "Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage., [RefSeq, PubMed]; G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity., [UniProtKB, PubMed, PubMed]; Genetic ablation of metabotropic glutamate receptor 5 in rats results in an autism-like behavioral phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats. Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. doi: 10.1007/s00213-023-06368-w. PMID: 37145309], [RefSeq, PubMed]; The mGluR5-mediated Arc activation protects against experimental traumatic brain injury in rats., [RefSeq, PubMed]; Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001639 PLC activating G protein-coupled glutamate receptor activity;GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity;GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential;GO:0004930 G protein-coupled receptor activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0035106 operant conditioning;GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:1900039 positive regulation of cellular response to hypoxia;GO:0001659 temperature homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P31424-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KL00-1", "uniprot_id": [ { "id": "PIEZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q0KL00", "type": "external" } ], "mass": 290315.0, "length": 2535, "protein_name": "Piezo-type mechanosensitive ion channel component 1", "gene_name": "Piezo1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Piezo1; Fam38a", "gene_names_refseq": "", "protein_names_uniprotkb": "Piezo-type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); dehydrated hereditary stomatocytosis (Disease Ontology:DOID:0111575); dehydrated hereditary stomatocytosis 1 (Disease Ontology:DOID:0111576); distal arthrogryposis type 5 (Disease Ontology:DOID:0111608)", "pathway": " (rno:361430)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16854388;22673903;29393594", "class_list": "", "function": "Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (By similarity). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (By similarity). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium (By similarity). Conductance to monovalent alkali ions is highest for K(+), intermediate for Na(+) and lowest for Li(+) (By similarity). Divalent ions except for Mn(2+) permeate the channel but more slowly than the monovalent ions and they also reduce K(+) currents (By similarity). Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (By similarity). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (By similarity). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing (By similarity). Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (By similarity). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells (By similarity). In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca(2+) influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005261 monoatomic cation channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0140135 mechanosensitive monoatomic cation channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0042391 regulation of membrane potential;GO:0006812 monoatomic cation transport;GO:0071260 cellular response to mechanical stimulus;GO:0050982 detection of mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0KL00-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HD3-1", "uniprot_id": [ { "id": "NASP_RAT", "url": "https://www.uniprot.org/uniprot/Q66HD3", "type": "external" } ], "mass": 84200.0, "length": 776, "protein_name": "Nuclear autoantigenic sperm protein", "gene_name": "Nasp", "organism": "Rat", "refseq_name": "nuclear autoantigenic sperm protein isoform a", "refseq_ac": [ { "id": "NP_001005543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005543", "type": "external" } ], "gene_names_uniprotkb": "Nasp", "gene_names_refseq": "Nasp", "protein_names_uniprotkb": "Nuclear autoantigenic sperm protein; NASP", "protein_names_refseq": "nuclear autoantigenic sperm protein (histone-binding); nuclear autoantigenic sperm protein isoform a", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (rno:298441)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22194605;22673903", "class_list": "", "function": "An increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development., [RefSeq, PubMed]; Component of the histone chaperone network (By similarity). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (By similarity). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015031 protein transport;GO:0006260 DNA replication;GO:0008584 male gonad development;GO:0000082 G1/S transition of mitotic cell cycle;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08561-1", "uniprot_id": [ { "id": "PI4KB_RAT", "url": "https://www.uniprot.org/uniprot/O08561", "type": "external" } ], "mass": 91655.0, "length": 816, "protein_name": "Phosphatidylinositol 4-kinase beta", "gene_name": "Pi4kb", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-kinase beta isoform 1", "refseq_ac": [ { "id": "NP_112345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112345", "type": "external" } ], "gene_names_uniprotkb": "Pi4kb; Pik4cb", "gene_names_refseq": "Pi4kb; Pik4cb", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase beta; 2.7.1.67; PI4K-beta; PI4Kbeta; PtdIns 4-kinase beta", "protein_names_refseq": "PI4K-beta; PI4Kbeta; catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase beta isoform 1; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; ptdIns 4-kinase beta", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 87 (Disease Ontology:DOID:0070606)", "pathway": " (rno:81747); (R-RNO-1660514)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11526106;12244129;14607934;14607979;18474610;19458041;22673903;23899475;8973579", "class_list": "", "function": "NCS-1 protein and 1-phosphatidylinositol 4-kinase b interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis., [RefSeq, PubMed]; Overexpression of a PI4K beta mutant in rat mast cells inhibits IgE receptor-triggered phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and exocytosis., [RefSeq, PubMed]; Phosphatidylinositol-4 kinase in basolateral membranes from kidney cells is activated by sphingosine-1-phosphate, [RefSeq, PubMed]; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:8973579). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (PubMed:8973579). May play an important role in the inner ear development., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that the anti-inflammatory effects of sanguinarine on PtdIns 3-kinase signaling pathway are more likely an indirect effect and emphasize the importance of the cross talk between type II PtdIns 4-kinases and PtdIns 3-kinases., [RefSeq, PubMed]; Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0071889 14-3-3 protein binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0007040 lysosome organization;GO:0048015 phosphatidylinositol-mediated signaling;GO:0048839 inner ear development;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O08561-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54748-1", "uniprot_id": [ { "id": "PDE4A_RAT", "url": "https://www.uniprot.org/uniprot/P54748", "type": "external" } ], "mass": 93439.0, "length": 844, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4A", "gene_name": "Pde4a", "organism": "Rat", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 1", "refseq_ac": [ { "id": "NP_037233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037233", "type": "external" } ], "gene_names_uniprotkb": "Pde4a", "gene_names_refseq": "DPDE2; PHOSA; Pde4a", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4A; 3.1.4.53; DPDE2; cAMP-specific phosphodiesterase 4A", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4A isoform 1; 3',5'-cyclic-AMP phosphodiesterase 4A; PDE4A10 cAMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific phosphodiesterase 4A; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)", "tax_id": 10116, "disease": "brucellosis (Disease Ontology:DOID:11077); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:25638); (R-RNO-180024); (R-RNO-418555)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11306681;21323643;22673903;23986500;2542942;2546153;33184031;35219697;37004962;7958996;8557632;8663181", "class_list": "", "function": "ERK regulation of phosphodiesterase 4 enhances dopamine-stimulated AMPA receptor membrane insertion., [RefSeq, PubMed]; Efficiently hydrolyzes cAMP., [UniProtKB, PubMed, PubMed]; Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes., [UniProtKB, PubMed, PubMed]; In vitro inhibition of phosphodiesterase type 4 enhances rat corpus cavernosum nerve-mediated relaxation induced by gasotransmitters., [RefSeq, PubMed]; Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model., [RefSeq, PubMed]; Selective changes in cytosolic beta-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P14645;Q9EQR7", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0071466 cellular response to xenobiotic stimulus;GO:0050804 modulation of chemical synaptic transmission;GO:0007608 sensory perception of smell;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P54748-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63803-1", "uniprot_id": [ { "id": "GNAS1_RAT", "url": "https://www.uniprot.org/uniprot/Q63803", "type": "external" } ], "mass": 122887.0, "length": 1144, "protein_name": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "gene_name": "Gnas", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gnas; Gnas1", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Adenylate cyclase-stimulating G alpha protein; Extra large alphas protein; G-alpha-8; XLalphas", "protein_names_refseq": "", "tax_id": 10116, "disease": "pseudohypoparathyroidism type 1C (Disease Ontology:DOID:0051013); pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222); polycystic kidney disease (Disease Ontology:DOID:0080322); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); ACTH-independent macronodular adrenal hyperplasia 1 (Disease Ontology:DOID:0111623); pituitary adenoma 3 (Disease Ontology:DOID:0112010); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pancreatic cancer (Disease Ontology:DOID:1793); McCune Albright syndrome (Disease Ontology:DOID:1858); pseudopseudohypoparathyroidism (Disease Ontology:DOID:4183); pseudohypoparathyroidism (Disease Ontology:DOID:4184); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24896); (R-RNO-381676); (R-RNO-420092); (R-RNO-432040); (R-RNO-9856530)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10729789;10931823;10931851;11447126;15148396;22673903;2820999;3086867;38168118;7500342;7997272;8347607;8486667;8856666", "class_list": "", "function": "Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation. Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP., [UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0071380 cellular response to prostaglandin E stimulus;GO:0071870 cellular response to catecholamine stimulus;GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63803-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0W5-1", "uniprot_id": [ { "id": "PACN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0W5", "type": "external" } ], "mass": 50449.0, "length": 441, "protein_name": "Protein kinase C and casein kinase substrate in neurons protein 1", "gene_name": "Pacsin1", "organism": "Rat", "refseq_name": "protein kinase C and casein kinase substrate in neurons protein 1", "refseq_ac": [ { "id": "NP_058990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058990", "type": "external" } ], "gene_names_uniprotkb": "Pacsin1", "gene_names_refseq": "Pacsin1", "protein_names_uniprotkb": "Protein kinase C and casein kinase substrate in neurons protein 1; Dynamin PRD-interacting protein; Dynamin proline-rich domain-interacting protein; SdpI; Synaptic, dynamin-associated protein I; Syndapin-1; Syndapin-I", "protein_names_refseq": "dynamin PRD-interacting protein; dynamin proline-rich domain-interacting protein; protein kinase C and casein kinase substrate in neurons protein 1; sdpI; synaptic dynamin-binding protein; synaptic, dynamin-associated protein I; syndapin-1; syndapin-I", "tax_id": 10116, "disease": "Fanconi renotubular syndrome 3 (Disease Ontology:DOID:0080759); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:29704); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11082044;15930129;16648848;17437541;17956734;18683930;19846719;21725280;22355135;22673903;27488904;34290082;9950691", "class_list": "", "function": "Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PACSIN1 is a versatile membrane deformation protein that links the endocytic and recycling machineries essential for dynamic AMPA receptor trafficking in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0007015 actin filament organization;GO:0030100 regulation of endocytosis;GO:0072659 protein localization to plasma membrane;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9Z0W5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2X5-1", "uniprot_id": [ { "id": "HOME3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2X5", "type": "external" } ], "mass": 39891.0, "length": 358, "protein_name": "Homer protein homolog 3", "gene_name": "Homer3", "organism": "Rat", "refseq_name": "homer protein homolog 3 isoform 3", "refseq_ac": [ { "id": "NP_445762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445762", "type": "external" } ], "gene_names_uniprotkb": "Homer3; Vesl3", "gene_names_refseq": "Homer3; Vesl-3", "protein_names_uniprotkb": "Homer protein homolog 3; Homer-3; VASP/Ena-related gene up-regulated during seizure and LTP 3; Vesl-3", "protein_names_refseq": "VASP/Ena-related gene up-regulated during seizure and LTP 3; homer homolog 3; homer protein homolog 3 isoform 3; homer protein homolog 3; homer scaffolding protein 3; homer, neuronal immediate early gene, 3; homer-3", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:29548); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;27890541", "class_list": "", "function": "Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The acute foodshake-stress induced reduction of Homer3 mRNA levels compared to sham animals at the same time point that was prevented by chronic treatment with desipramine., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry;GO:1905232 cellular response to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z2X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63433-1", "uniprot_id": [ { "id": "PKN1_RAT", "url": "https://www.uniprot.org/uniprot/Q63433", "type": "external" } ], "mass": 104468.0, "length": 946, "protein_name": "Serine/threonine-protein kinase N1", "gene_name": "Pkn1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase N1", "refseq_ac": [ { "id": "NP_058871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058871", "type": "external" } ], "gene_names_uniprotkb": "Pkn1; Pkn; Prk1; Prkcl1", "gene_names_refseq": "PAK-1; Pkn1; Prkcl1", "protein_names_uniprotkb": "Serine/threonine-protein kinase N1; 2.7.11.13; PAK-1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; Protein-kinase C-related kinase 1; Serine-threonine protein kinase N", "protein_names_refseq": "protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase PKN; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine-protein kinase N1", "tax_id": 10116, "disease": "", "pathway": " (rno:29355); (R-RNO-5625740); (R-RNO-5625886); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "15375078;22673903;22893700;29045568;29393594;36897022;8051089;8135837;8943281", "class_list": "", "function": "Cardioprotection by PKN1 is associated with reduced CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity., [RefSeq, PubMed]; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation (PubMed:15375078, PubMed:8051089). Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14 (By similarity). Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration., [RefSeq, PubMed]; Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P748;Q8VIJ2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0031410 cytoplasmic vesicle;GO:0032154 cleavage furrow", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0002637 regulation of immunoglobulin production;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63433-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10037-1", "uniprot_id": [ { "id": "PIT1_RAT", "url": "https://www.uniprot.org/uniprot/P10037", "type": "external" } ], "mass": 32903.0, "length": 291, "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "Pou1f1", "organism": "Rat", "refseq_name": "pituitary-specific positive transcription factor 1 isoform X1", "refseq_ac": [ { "id": "XP_006248036", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006248036", "type": "external" } ], "gene_names_uniprotkb": "Pou1f1; Ghf-1; Pit-1; Pit1", "gene_names_refseq": "GHF1A; GHF1; PIT1Z; Pit1; Pou1f1", "protein_names_uniprotkb": "Pituitary-specific positive transcription factor 1; GHF-1; Growth hormone factor 1; PIT-1", "protein_names_refseq": "pituitary-specific positive transcription factor 1 isoform X1", "tax_id": 10116, "disease": "combined or isolated pituitary hormone deficiency 1 (Disease Ontology:DOID:0061019); pituitary gland disease (Disease Ontology:DOID:53)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "1561093;1569967;1600947;2902927;2902928;9009203", "class_list": "", "function": "Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63431", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0021984 adenohypophysis development;GO:0060126 somatotropin secreting cell differentiation;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10037-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPX4-1", "uniprot_id": [ { "id": "P2Y12_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPX4", "type": "external" } ], "mass": 39047.0, "length": 343, "protein_name": "P2Y purinoceptor 12", "gene_name": "P2ry12", "organism": "Rat", "refseq_name": "P2Y purinoceptor 12", "refseq_ac": [ { "id": "NP_073637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073637", "type": "external" } ], "gene_names_uniprotkb": "P2ry12; P2y12", "gene_names_refseq": "P2ry12; P2y12", "protein_names_uniprotkb": "P2Y purinoceptor 12; P2Y12 platelet ADP receptor; P2Y12", "protein_names_refseq": "P2Y purinoceptor 12; P2Y12 platelet ADP receptor; purinergic receptor P2Y, G-protein coupled, 12", "tax_id": 10116, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); platelet-type bleeding disorder 8 (Disease Ontology:DOID:0060692); thrombosis (Disease Ontology:DOID:0060903); asthma (Disease Ontology:DOID:2841); cerebrovascular disease (Disease Ontology:DOID:6713); abdominal aortic aneurysm (Disease Ontology:DOID:7693); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:64803); (R-RNO-392170); (R-RNO-417957); (R-RNO-418594)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11196645;16641100;30084083;30598122;33908199;35581507;35644421", "class_list": "", "function": "Gene expression of the metabotropic purinergic receptor P2Y12 and the fractalkine receptor CX3CR1 was downregulated in the Medulla oblongata of Spontaneously Hypertensive Rats compared to Wistar kyoto rats (by 37.3% and 30.9% respectively)., [RefSeq, PubMed]; Implication of P2Y12 receptor in uc.48+-mediated abnormal sympathoexcitatory reflex via superior cervical ganglia in myocardial ischemic rats., [RefSeq, PubMed]; P2Y12 inhibition in macrophages reduces ventricular arrhythmias in rats after myocardial ischemia-reperfusion., [RefSeq, PubMed]; Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation., [UniProtKB, PubMed]; That P2Y12 receptor in the stellate ganglia may participate in developing diabetic autonomic neuropathy Erratum:[Purinergic Signal. 2021 Mar;17(1):163. doi: 10.1007/s11302-020-09741-y. PMID: 33185789], [RefSeq, PubMed]; Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0001609 G protein-coupled adenosine receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0005901 caveola;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:1904139 regulation of microglial cell migration;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EPX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z272-1", "uniprot_id": [ { "id": "GIT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z272", "type": "external" } ], "mass": 85231.0, "length": 770, "protein_name": "ARF GTPase-activating protein GIT1", "gene_name": "Git1", "organism": "Rat", "refseq_name": "ARF GTPase-activating protein GIT1", "refseq_ac": [ { "id": "NP_114002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114002", "type": "external" } ], "gene_names_uniprotkb": "Git1", "gene_names_refseq": "Git1", "protein_names_uniprotkb": "ARF GTPase-activating protein GIT1; ARF GAP GIT1; CAT-1; CAT1; Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GRK-interactor 1", "protein_names_refseq": "ARF GAP GIT1; ARF GTPase-activating protein GIT1; CAT-1; CAT1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1); G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1; GRK-interactor 1; cool-associated and tyrosine-phosphorylated protein 1", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:83709); (R-RNO-3928664); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9013424)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10938112;12153727;12473661;12629171;12695502;15800193;15923189;17310244;18683930;19136011;22673903;24297929;25009255;25284783;29191942;32223487;34002676;34154701;36044673;9826657", "class_list": "", "function": "Beta-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells., [RefSeq, PubMed]; Exosomes derived from GIT1-overexpressing bone marrow mesenchymal stem cells promote traumatic spinal cord injury recovery in a rat model., [RefSeq, PubMed]; GTPase-activating protein for ADP ribosylation factor family members, including ARF1 (PubMed:9826657). Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (PubMed:9826657). Through PAK1 activation, positively regulates microtubule nucleation during interphase. Plays a role in the regulation of cytokinesis; for this function, may act in a pathway also involving ENTR1 and PTPN13 (By similarity). May promote cell motility both by regulating focal complex dynamics and by the activation of RAC1 (PubMed:10938112). May act as scaffold for MAPK1/3 signal transduction, recruiting MAPK1/3 to focal adhesions after EGF stimulation via a Src-dependent pathway, hence stimulating cell migration (PubMed:15923189). Plays a role in brain development and function. Involved in the regulation of spine density and synaptic plasticity that is required for processes involved in learning (By similarity). Plays an important role in dendritic spine morphogenesis and synapse formation (PubMed:12695502, PubMed:15800193, PubMed:17310244, PubMed:24297929, PubMed:25009255). In hippocampal neurons, recruits guanine nucleotide exchange factors (GEFs), such as ARHGEF7/beta-PIX, to the synaptic membrane. These in turn locally activate RAC1, which is an essential step for spine morphogenesis and synapse formation (PubMed:12473661). May contribute to the organization of presynaptic active zones through oligomerization and formation of a Piccolo/PCLO-based protein network, which includes ARHGEF7/beta-PIX and FAK1 (PubMed:12473661). In neurons, through its interaction with liprin-alpha family members, may be required for AMPA receptor (GRIA2/3) proper targeting to the cell membrane (PubMed:12629171). In complex with GABA(A) receptors and ARHGEF7, plays a crucial role in regulating GABA(A) receptor synaptic stability, maintaining GPHN/gephyrin scaffolds and hence GABAergic inhibitory synaptic transmission, by locally coordinating RAC1 and PAK1 downstream effector activity, leading to F-actin stabilization (PubMed:25284783). May also be important for RAC1 downstream signaling pathway through PAK3 and regulation of neuronal inhibitory transmission at presynaptic input (By similarity). Required for successful bone regeneration during fracture healing. The function in intramembranous ossification may, at least partly, exerted by macrophages in which GIT1 is a key negative regulator of redox homeostasis, IL1B production, and glycolysis, acting through the ERK1/2/NRF2/NFE2L2 axis (By similarity). May also play a role in angiogenesis during fracture healing (By similarity). In this process, may regulate activation of the canonical NF-kappa-B signal in bone mesenchymal stem cells by enhancing the interaction between NEMO and 'Lys-63'-ubiquitinated RIPK1/RIP1, eventually leading to enhanced production of VEGFA and others angiogenic factors (By similarity). Essential for VEGF signaling through the activation of phospholipase C-gamma and ERK1/2, hence may control endothelial cell proliferation and angiogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines., [RefSeq, PubMed]; Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1., [RefSeq, PubMed]; Kinesin-1-dependent transport of the betaPIX/GIT complex in neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044305 calyx of Held;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:2000646 positive regulation of receptor catabolic process;GO:0032013 negative regulation of ARF protein signal transduction;GO:0007626 locomotory behavior;GO:0048013 ephrin receptor signaling pathway;GO:0032691 negative regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9Z272-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35567-1", "uniprot_id": [ { "id": "PUR9_RAT", "url": "https://www.uniprot.org/uniprot/O35567", "type": "external" } ], "mass": 64208.0, "length": 592, "protein_name": "Bifunctional purine biosynthesis protein ATIC", "gene_name": "Atic", "organism": "Rat", "refseq_name": "bifunctional purine biosynthesis protein ATIC", "refseq_ac": [ { "id": "NP_112276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112276", "type": "external" } ], "gene_names_uniprotkb": "Atic; Purh", "gene_names_refseq": "Atic", "protein_names_uniprotkb": "Bifunctional purine biosynthesis protein ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR formyltransferase; AICAR transformylase/inosine monophosphate cyclohydrolase; AICAR transformylase; ATIC; IMP synthase; Inosinicase", "protein_names_refseq": "AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH-like; bifunctional purine biosynthesis protein PURH", "tax_id": 10116, "disease": "purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (rno:81643); (R-RNO-73817)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "25687571;29393594;38181403;9332377", "class_list": "", "function": "Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (By similarity). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data identified ATIC as a physical partner of internalized insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions of rat's liver. They show that ATIC later accumulates in G/E . SiRNA-mediated partial knockdown of ATIC decreased tyrosine phosphorylation of IR and regulated IR endocytosis in HEK293 cells. Treatment with ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis., [RefSeq, PubMed]; Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN16", "ec_number_list": [ { "id": "2.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.3", "type": "external" }, { "id": "3.5.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.10", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003937 IMP cyclohydrolase activity;GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0003360 brainstem development;GO:0046654 tetrahydrofolate biosynthetic process;GO:0021987 cerebral cortex development;GO:0031100 animal organ regeneration;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35567-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIX5-1", "uniprot_id": [ { "id": "CHD8_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIX5", "type": "external" } ], "mass": 290692.0, "length": 2581, "protein_name": "ATP-dependent chromatin remodeler CHD8", "gene_name": "Chd8", "organism": "Rat", "refseq_name": "ATP-dependent chromatin remodeler CHD8", "refseq_ac": [ { "id": "NP_001334590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334590", "type": "external" } ], "gene_names_uniprotkb": "Chd8; CHD8", "gene_names_refseq": "CHD-8; Chd8", "protein_names_uniprotkb": "ATP-dependent chromatin remodeler CHD8; 3.6.4.-; Axis duplication inhibitor; CHD-8; Chromo domain-containing protein 8; Duplin", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD8; ATP-dependent helicase CHD8; axis duplication inhibitor; beta-catenin binding protein; chromo domain-containing protein 8; duplin", "tax_id": 10116, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:65027); (R-RNO-3769402); (R-RNO-9943962)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10921920;11744694;16452319;22673903;23071553;29393594;29920279;38843836", "class_list": "", "function": "ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL., [UniProtKB, PubMed, PubMed, HAMAP, UniProtKB, UniProtKB]; Data indicate that CHD8 exhibits a dual function through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity., [RefSeq, PubMed]; These data add Chd8 to the short list of known nuclear AKAPs, and implicate a function for Chd8 in post-natal rat cardiac development, [RefSeq, PubMed]; This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene in mice causes early embryonic lethality due to widespread apoptosis. Heterozygous loss of function mutations in mice result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0071339 MLL1 complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001964 startle response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JIX5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MM4-1", "uniprot_id": [ { "id": "TRAD1_RAT", "url": "https://www.uniprot.org/uniprot/Q99MM4", "type": "external" } ], "mass": 63806.0, "length": 576, "protein_name": "TRAF-type zinc finger domain-containing protein 1", "gene_name": "Trafd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trafd1; Fln29", "gene_names_refseq": "", "protein_names_uniprotkb": "TRAF-type zinc finger domain-containing protein 1; Protein FLN29", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114635)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11748220;22673903;29393594", "class_list": "", "function": "Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M806", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0034097 response to cytokine;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35413-1", "uniprot_id": [ { "id": "SRBS2_RAT", "url": "https://www.uniprot.org/uniprot/O35413", "type": "external" } ], "mass": 134057.0, "length": 1196, "protein_name": "Sorbin and SH3 domain-containing protein 2", "gene_name": "Sorbs2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sorbs2; Argbp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorbin and SH3 domain-containing protein 2; Arg-binding protein 2; Arg/Abl-interacting protein 2; ArgBP2; Neural ArgBP2; Sorbin; nArgBP2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114901)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10521485;11786189;15128873;15659545;16125169;22673903", "class_list": "", "function": "Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). Isoform 2 increases water and sodium absorption in the intestine and gall-bladder., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923T8", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030027 lamellipodium;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0095500 acetylcholine receptor signaling pathway;GO:0007010 cytoskeleton organization;GO:0061049 cell growth involved in cardiac muscle cell development;GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O35413-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7G1-1", "uniprot_id": [ { "id": "SKAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7G1", "type": "external" } ], "mass": 40903.0, "length": 354, "protein_name": "Src kinase-associated phosphoprotein 1", "gene_name": "Skap1", "organism": "Rat", "refseq_name": "src kinase-associated phosphoprotein 1", "refseq_ac": [ { "id": "NP_775433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775433", "type": "external" } ], "gene_names_uniprotkb": "Skap1; Scap1; Skap55", "gene_names_refseq": "Scap1; Skap1; Skap55", "protein_names_uniprotkb": "Src kinase-associated phosphoprotein 1; SKAP-55; SKAP55 adapter protein; Src family-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa; pp55", "protein_names_refseq": "SKAP-55; SKAP55 adapter protein; SKAP55 adaptor protein; pp55; src family-associated phosphoprotein 1; src kinase-associated phosphoprotein 1; src kinase-associated phosphoprotein of 55 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:286975)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12681493;15199160", "class_list": "", "function": "Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493)., [UniProtKB, UniProtKB, PubMed]; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHI6", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0042169 SH2 domain binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0072659 protein localization to plasma membrane;GO:0050852 T cell receptor signaling pathway;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V7G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK25-1", "uniprot_id": [ { "id": "CLIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK25", "type": "external" } ], "mass": 148279.0, "length": 1320, "protein_name": "CAP-Gly domain-containing linker protein 1", "gene_name": "Clip1", "organism": "Rat", "refseq_name": "CAP-Gly domain-containing linker protein 1 isoform 1", "refseq_ac": [ { "id": "NP_113933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113933", "type": "external" } ], "gene_names_uniprotkb": "Clip1; Cyln1; Rsn", "gene_names_refseq": "CLIP-170; Clip1; Rsn", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 1; CLIP-170; Cytoplasmic linker protein 170; Restin", "protein_names_refseq": "CAP-Gly domain-containing linker protein 1 isoform 1; CAP-Gly domain-containing linker protein 1; cytoplasmic linker protein 170; restin (Reed-Steinberg cell-espressed intermediate filament-associated protein); restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)", "tax_id": 10116, "disease": "", "pathway": " (rno:65201); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "11290329;16148041;20519438;21273437;21430156;22673903;26972003", "class_list": "", "function": "Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking., [UniProtKB, UniProtKB]; CLIPs enable neuronal polarization by controlling the stabilization of microtubules and growth cone dynamics., [RefSeq, PubMed]; Indicating that CLIPs possess an intrinsic affinity for growing microtubule ends, which is enhanced by an interaction with the EBs., [RefSeq, PubMed]; We postulate that mTOR controls dendritic arbor morphology by enhancing cross talk between dynamic microtubules and actin through CLIP-170 and IQGAP1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K3T3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0051010 microtubule plus-end binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization;GO:0044861 protein transport into plasma membrane raft;GO:1900006 positive regulation of dendrite development;GO:0001578 microtubule bundle formation;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JK25-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25961-1", "uniprot_id": [ { "id": "PTH1R_RAT", "url": "https://www.uniprot.org/uniprot/P25961", "type": "external" } ], "mass": 66261.0, "length": 591, "protein_name": "Parathyroid hormone/parathyroid hormone-related peptide receptor", "gene_name": "Pth1r", "organism": "Rat", "refseq_name": "parathyroid hormone/parathyroid hormone-related peptide receptor precursor", "refseq_ac": [ { "id": "NP_064458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064458", "type": "external" } ], "gene_names_uniprotkb": "Pth1r; Pthr1; Pthr", "gene_names_refseq": "PTHrel; Pth1r; Pthr1; Pthr", "protein_names_uniprotkb": "Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Parathyroid hormone 1 receptor", "protein_names_refseq": "PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor precursor; parathyroid hormone/parathyroid hormone-related peptide receptor", "tax_id": 10116, "disease": "chondrodysplasia Blomstrand type (Disease Ontology:DOID:0060387); Jansen's metaphyseal chondrodysplasia (Disease Ontology:DOID:0080020); primary failure of tooth eruption (Disease Ontology:DOID:0111341); Eiken syndrome (Disease Ontology:DOID:0111732); hypercalcemia (Disease Ontology:DOID:12678); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (rno:56813); (R-RNO-373080)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1313566;25278090;30504697;30926678;8020952", "class_list": "", "function": "G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:1313566). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity)., [UniProtKB, UniProtKB, PubMed]; G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our study thus demonstrates the new role of PTHrP in fibronectin up-regulation for the first time in glomerular mesangial cells. These data also provided new insights to guide development of therapy for glomerular sclerosis Publication Status: Online-Only, [RefSeq, PubMed]; PTHrP (1-40) stimulates calcium uptake via PTHR1 receptor and PKC alpha/beta signaling pathway in rat enterocytes, and calcium transporters TRPV6 and CaBP-D9k are necessary for this stimulatory effect., [RefSeq, PubMed]; Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXV4-1", "uniprot_id": [ { "id": "SAM50_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXV4", "type": "external" } ], "mass": 51960.0, "length": 469, "protein_name": "Sorting and assembly machinery component 50 homolog", "gene_name": "Samm50", "organism": "Rat", "refseq_name": "sorting and assembly machinery component 50 homolog", "refseq_ac": [ { "id": "NP_001004241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004241", "type": "external" } ], "gene_names_uniprotkb": "Samm50", "gene_names_refseq": "Samm50", "protein_names_uniprotkb": "Sorting and assembly machinery component 50 homolog", "protein_names_refseq": "sorting and assembly machinery component 50 homolog A; sorting and assembly machinery component 50 homolog", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:300111); (R-RNO-9013404)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19343716;27213235", "class_list": "", "function": "Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001401 SAM complex;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0042407 cristae formation;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AXV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG77-1", "uniprot_id": [ { "id": "DXO_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG77", "type": "external" } ], "mass": 45299.0, "length": 397, "protein_name": "Decapping and exoribonuclease protein", "gene_name": "Dxo", "organism": "Rat", "refseq_name": "decapping and exoribonuclease protein", "refseq_ac": [ { "id": "NP_997662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997662", "type": "external" } ], "gene_names_uniprotkb": "Dxo; Dom3z", "gene_names_refseq": "Dom3z; Dxo", "protein_names_uniprotkb": "Decapping and exoribonuclease protein; 3.1.13.-; 3.6.1.-; 5'-3' exoribonuclease DXO; DXO; DeNADding enzyme DXO; Dom-3 homolog Z; NAD-capped RNA hydrolase DXO", "protein_names_refseq": "5'-3' exoribonuclease DXO; NAD-capped RNA hydrolase DXO; deNADding enzyme DXO; decapping and exoribonuclease protein; protein Dom3Z", "tax_id": 10116, "disease": "", "pathway": " (rno:361799)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Preferentially acts on NAD-capped transcripts in response to environmental stress (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA. Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0034353 mRNA 5'-diphosphatase activity;GO:0000287 magnesium ion binding;GO:0003729 mRNA binding;GO:0000166 nucleotide binding;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050779 RNA destabilization;GO:0071028 nuclear mRNA surveillance;GO:0006402 mRNA catabolic process;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64548-1", "uniprot_id": [ { "id": "RTN1_RAT", "url": "https://www.uniprot.org/uniprot/Q64548", "type": "external" } ], "mass": 83002.0, "length": 777, "protein_name": "Reticulon-1", "gene_name": "Rtn1", "organism": "Rat", "refseq_name": "reticulon-1", "refseq_ac": [ { "id": "NP_446317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446317", "type": "external" } ], "gene_names_uniprotkb": "Rtn1; Nsp", "gene_names_refseq": "Nsp; Rtn1", "protein_names_uniprotkb": "Reticulon-1; Neuroendocrine-specific protein; S-rex", "protein_names_refseq": "S-rex; neuroendocrine-specific protein; reticulon-1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:116644)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12354640;22673903;28981095;30352262;31002913;33372676;8793864", "class_list": "", "function": "Collectively, these data support for the first time that RTN1-C may represent a novel candidate for therapies against cerebral ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; High glucose significantly increases RTN1-C expression in OGD/R-treated cells. RTN1-C affects high glucose-treated OGD/R cells by exacerbating ER stress., [RefSeq, PubMed]; Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knock-down of RTN1-c protected neurons against traumatic neuronal injury via preservation of calcium homeostasis., [RefSeq, PubMed]; Neuroendocrine-specific protein-A (NSP-A) as ethanol-responsive gene in the fetal rat brain, [RefSeq, PubMed]; RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64547", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0030182 neuron differentiation;GO:0071787 endoplasmic reticulum tubular network formation;GO:1990809 endoplasmic reticulum tubular network membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q64548-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF21-1", "uniprot_id": [ { "id": "SMAG1_RAT", "url": "https://www.uniprot.org/uniprot/B5DF21", "type": "external" } ], "mass": 67150.0, "length": 610, "protein_name": "Protein Smaug homolog 1", "gene_name": "Samd4a", "organism": "Rat", "refseq_name": "protein Smaug homolog 1", "refseq_ac": [ { "id": "NP_001386703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386703", "type": "external" } ], "gene_names_uniprotkb": "Samd4a; Smaug1", "gene_names_refseq": "Samd4a; Samd4", "protein_names_uniprotkb": "Protein Smaug homolog 1; Smaug 1; Sterile alpha motif domain-containing protein 4A", "protein_names_refseq": "protein Smaug homolog 1; smaug 1; sterile alpha motif domain containing 4; sterile alpha motif domain-containing protein 4A", "tax_id": 10116, "disease": "", "pathway": " (rno:305826)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16221671;22673903", "class_list": "", "function": "Acts as a translational repressor of SRE-containing messengers., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0000932 P-body", "go_biological_process": "GO:0045727 positive regulation of translation;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0150052 regulation of postsynapse assembly;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B5DF21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04157-1", "uniprot_id": [ { "id": "PTPRC_RAT", "url": "https://www.uniprot.org/uniprot/P04157", "type": "external" } ], "mass": 143269.0, "length": 1273, "protein_name": "Receptor-type tyrosine-protein phosphatase C", "gene_name": "Ptprc", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase C isoform 3 precursor", "refseq_ac": [ { "id": "NP_001103357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103357", "type": "external" } ], "gene_names_uniprotkb": "Ptprc", "gene_names_refseq": "CD45; L-CA; Lca; Ptprc; RT7; T200", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase C; 3.1.3.48; L-CA; Leukocyte common antigen; T200", "protein_names_refseq": "T200 glycoprotein; leucocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; protein tyrosine phosphatase, receptor-type, c polypeptide; receptor-type tyrosine-protein phosphatase C isoform 3 precursor; receptor-type tyrosine-protein phosphatase C", "tax_id": 10116, "disease": "severe combined immunodeficiency 105 (Disease Ontology:DOID:0061074); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); severe combined immunodeficiency (Disease Ontology:DOID:627); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:24699); (R-RNO-202427); (R-RNO-416700); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "21454685;22673903;2440674;3158393", "class_list": "", "function": "Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0045202 synapse", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0001779 natural killer cell differentiation;GO:0002711 positive regulation of T cell mediated immunity;GO:0050857 positive regulation of antigen receptor-mediated signaling pathway;GO:0016311 dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04157-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41777-1", "uniprot_id": [ { "id": "NOLC1_RAT", "url": "https://www.uniprot.org/uniprot/P41777", "type": "external" } ], "mass": 73564.0, "length": 704, "protein_name": "Nucleolar and coiled-body phosphoprotein 1", "gene_name": "Nolc1", "organism": "Rat", "refseq_name": "nucleolar and coiled-body phosphoprotein 1", "refseq_ac": [ { "id": "NP_074060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074060", "type": "external" } ], "gene_names_uniprotkb": "Nolc1", "gene_names_refseq": "Nolc1; Nopp140", "protein_names_uniprotkb": "Nucleolar and coiled-body phosphoprotein 1; 140 kDa nucleolar phosphoprotein; Nopp140; Nucleolar 130 kDa protein; Nucleolar phosphoprotein p130", "protein_names_refseq": "140 kDa nucleolar phosphoprotein; nucleolar 130 kDa protein; nucleolar and coiled-body phosphoprotein 1; nucleolar phosphoprotein 140; nucleolar phosphoprotein p130", "tax_id": 10116, "disease": "", "pathway": " (rno:64896)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10679015;1623516;16493179;22673903", "class_list": "", "function": "Inappropriate expression of grn and/or p130 genes in the brains of male and female neonatal rats by perinatal exposure to phthalate/adipate esters may exert permanent effects on the hypothalamus, thereby decreasing sexual behavior after maturation, [RefSeq, PubMed]; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LPS3", "ec_number_list": [], "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0015030 Cajal body", "go_biological_process": "GO:0014029 neural crest formation;GO:0007000 nucleolus organization;GO:0006417 regulation of translation;GO:0007409 axonogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41777-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPA0-1", "uniprot_id": [ { "id": "DRP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPA0", "type": "external" } ], "mass": 108045.0, "length": 957, "protein_name": "Dystrophin-related protein 2", "gene_name": "Drp2", "organism": "Rat", "refseq_name": "dystrophin-related protein 2", "refseq_ac": [ { "id": "NP_001382005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382005", "type": "external" } ], "gene_names_uniprotkb": "Drp2", "gene_names_refseq": "DRP-2; Drp2", "protein_names_uniprotkb": "Dystrophin-related protein 2; DRP-2", "protein_names_refseq": "dystrophin-related protein 2 A-form; dystrophin-related protein 2", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:66027); (R-RNO-9913351)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11083927;11430802;17873297;22673903", "class_list": "", "function": "DRP-2 is a potential marker for escitalopram resistance in an animal model of stress and depression., [RefSeq, PubMed]; Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3V971", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0050808 synapse organization;GO:0007417 central nervous system development;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EPA0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JD4-1", "uniprot_id": [ { "id": "CLAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q99JD4", "type": "external" } ], "mass": 140638.0, "length": 1286, "protein_name": "CLIP-associating protein 2", "gene_name": "Clasp2", "organism": "Rat", "refseq_name": "CLIP-associating protein 2", "refseq_ac": [ { "id": "NP_446174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446174", "type": "external" } ], "gene_names_uniprotkb": "Clasp2", "gene_names_refseq": "Clasp2", "protein_names_uniprotkb": "CLIP-associating protein 2; Cytoplasmic linker-associated protein 2", "protein_names_refseq": "CLIP-associating protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:114514); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "11290329;22673903;25265211;25344256;29393594;38843836", "class_list": "", "function": "GSK3beta may play an essential role in the electric field-induced cell polarization via CLASP2 regulation and beta-catenin coordination, [RefSeq, PubMed]; KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes., [RefSeq, PubMed]; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0002162 dystroglycan binding;GO:0051010 microtubule plus-end binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0045180 basal cortex;GO:1903754 cortical microtubule plus-end;GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:1903690 negative regulation of wound healing, spreading of epidermal cells;GO:0016477 cell migration;GO:0032869 cellular response to insulin stimulus;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99JD4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6J4I0-1", "uniprot_id": [ { "id": "PPR1B_RAT", "url": "https://www.uniprot.org/uniprot/Q6J4I0", "type": "external" } ], "mass": 22913.0, "length": 205, "protein_name": "Protein phosphatase 1 regulatory subunit 1B", "gene_name": "Ppp1r1b", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 1B", "refseq_ac": [ { "id": "NP_612530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612530", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r1b", "gene_names_refseq": "Darpp-32; Darpp32; Ppp1r1b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 1B; DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein", "protein_names_refseq": "dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; protein phosphatase 1 regulatory subunit 1B", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); Huntington's disease (Disease Ontology:DOID:12858); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); bipolar disorder (Disease Ontology:DOID:3312); brain infarction (Disease Ontology:DOID:3454); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:360616); (R-RNO-180024)", "pathway_count": 2, "publication_count": 49, "publication_id_list": "10604473;11578525;11954050;15066157;15287884;15536496;15659113;15686489;16029214;17125745;17499634;17884291;17920048;18985320;19393228;19460370;19559764;19818513;20384816;20519061;20731628;21376040;21843598;22143580;22192465;22427945;22673903;22877786;22952905;23313709;23385959;24847227;25395834;2557337;26142455;26893543;27771532;28257887;29093677;29354053;30181585;30338306;32718349;33096475;33530478;35581520;7721783;7931332;8226946", "class_list": "", "function": "Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B., [RefSeq, PubMed]; In the striatum of methamphetamine-sensitized rats, phosphothreonine-DARPP-32 immunoreactivities are increased, but DARPP-32 immunoreactivities are not significantly different., [RefSeq, PubMed]; Inhibitor of protein-phosphatase 1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that the M4 muscarinic receptor plays a critical role in modulating phosphorylation of DARPP-32-Thr75 in striatal medium spiny neurons; suggest that M4 receptor activation acts antagonistically with dopamine D1-like receptors within the striatum, and indicate that M4 receptors may be a potential target for the treatment of Parkinson's disease and other relevant central nervous system disorders., [RefSeq, PubMed]; The study measured DARPP32 and pThr34 DARPP32 in the brains of male Long-Evans rats with a history of sucrose self-administration followed by 1 or 30 days of abstinence and exposure to either overnight (acute) or one month (chronic) environmental enrichment (EE). Both acute and chronic EE reduced DARPP32 in the nucleus accumbens core and acute EE increased the ratio of phosphorylated to total DARPP32. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0031751 D4 dopamine receptor binding;GO:0031748 D1 dopamine receptor binding;GO:0004864 protein phosphatase inhibitor activity;GO:0031749 D2 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007621 negative regulation of female receptivity;GO:0006351 DNA-templated transcription;GO:0007613 memory;GO:0007626 locomotory behavior;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q6J4I0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63751-1", "uniprot_id": [ { "id": "VOME_RAT", "url": "https://www.uniprot.org/uniprot/Q63751", "type": "external" } ], "mass": 62793.0, "length": 589, "protein_name": "Vomeromodulin", "gene_name": "Bpifb9; LOC120101703; Rplp1l3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Bpifb9; LOC120101703; Rplp1l3; LOC690507; RYF3; Rplp1l3", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeromodulin; BPI fold-containing family B member 9", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:690507)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10049729;1752363;1915264", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 623, "biomarker_type": "", "glycan_count": 5, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q05703", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63751-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51794-1", "uniprot_id": [ { "id": "CLCN4_RAT", "url": "https://www.uniprot.org/uniprot/P51794", "type": "external" } ], "mass": 83701.0, "length": 747, "protein_name": "H(+)/Cl(-) exchange transporter 4", "gene_name": "Clcn4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clcn4; Clcn4-2", "gene_names_refseq": "", "protein_names_uniprotkb": "H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; Chloride transporter ClC-4; ClC-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); Raynaud-Claes syndrome (Disease Ontology:DOID:0112060); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (rno:60586); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16222710;7730971", "class_list": "", "function": "Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015297 antiporter activity;GO:0005247 voltage-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006821 chloride transport;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DJJ3-1", "uniprot_id": [ { "id": "SGIP1_RAT", "url": "https://www.uniprot.org/uniprot/P0DJJ3", "type": "external" } ], "mass": 88585.0, "length": 827, "protein_name": "SH3-containing GRB2-like protein 3-interacting protein 1", "gene_name": "Sgip1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sgip1", "gene_names_refseq": "", "protein_names_uniprotkb": "SH3-containing GRB2-like protein 3-interacting protein 1; Endophilin-3-interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15919751;17626015;22673903", "class_list": "", "function": "May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0017124 SH3 domain binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0043195 terminal bouton;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0042594 response to starvation;GO:0097009 energy homeostasis;GO:2000253 positive regulation of feeding behavior;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0DJJ3-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QIX3-1", "uniprot_id": [ { "id": "ZNT3_RAT", "url": "https://www.uniprot.org/uniprot/Q6QIX3", "type": "external" } ], "mass": 41898.0, "length": 388, "protein_name": "Probable proton-coupled zinc antiporter SLC30A3", "gene_name": "Slc30a3", "organism": "Rat", "refseq_name": "probable proton-coupled zinc antiporter SLC30A3", "refseq_ac": [ { "id": "NP_001013261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013261", "type": "external" } ], "gene_names_uniprotkb": "Slc30a3", "gene_names_refseq": "Slc30a3; ZnT3", "protein_names_uniprotkb": "Probable proton-coupled zinc antiporter SLC30A3; Solute carrier family 30 member 3; Zinc transporter 3; ZnT-3", "protein_names_refseq": "probable proton-coupled zinc antiporter SLC30A3; solute carrier family 30 (zinc transporter), member 3; solute carrier family 30 protein; zinc transporter 3; zinc transporter ZnT-3; znT-3", "tax_id": 10116, "disease": "", "pathway": " (rno:366568)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15860731;19059322;19521526;22673903;25778834;29687372;36373349", "class_list": "", "function": "Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation. Publication Status: Online-Only, [RefSeq, PubMed]; Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rats treated with KD (EXP2) showed a significant down-regulated expression of ZnT-3, MT-3, ApoE, clusterin, and ACAT-1 in hippocampus, [RefSeq, PubMed]; SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity Publication Status: Online-Only, [RefSeq, PubMed]; The ZnT3/CB-D28k-associated Zn (2+)/Ca(2+) signaling might be involved in neonatal SE-induced long-term brain damage in the aspects of neurobehavioral impairment., [RefSeq, PubMed]; The coupling of zinc transporter 3 and Vglut1 transport mechanisms regulates neurotransmitter content in secretory vesicles, [RefSeq, PubMed]; ZnT-1, ZnT-3, CaMK II, PRG-1 expressions in hippocampus following neonatal seizure-induced cognitive deficit in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RJT1", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015297 antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097457 hippocampal mossy fiber;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0010043 response to zinc ion;GO:0051050 positive regulation of transport;GO:0099180 zinc ion import into synaptic vesicle;GO:0140916 zinc ion import into lysosome", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6QIX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3HS83-1", "uniprot_id": [ { "id": "ODAM_RAT", "url": "https://www.uniprot.org/uniprot/Q3HS83", "type": "external" } ], "mass": 30443.0, "length": 278, "protein_name": "Odontogenic ameloblast-associated protein", "gene_name": "Odam", "organism": "Rat", "refseq_name": "odontogenic ameloblast-associated protein precursor", "refseq_ac": [ { "id": "NP_001037739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037739", "type": "external" } ], "gene_names_uniprotkb": "Odam; Apin; EO-009", "gene_names_refseq": "Apin; Odam", "protein_names_uniprotkb": "Odontogenic ameloblast-associated protein; Apin", "protein_names_refseq": "APIN; odontogenic ameloblast-associated protein precursor; odontogenic ameloblast-associated protein; odontogenic, ameloblast asssociated", "tax_id": 10116, "disease": "", "pathway": " (rno:641555)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16674676;17451507;17647262;21092812;21154245;25911094", "class_list": "", "function": "Accelerates reactionary dentin formation close to the pulp exposure area, [RefSeq, PubMed]; ODAM and AMTN have a role at the cell-tooth interface, and that ODAM is likely also implicated in cellular events during formation and regeneration of the junctional epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals., [RefSeq, PubMed]; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0010628 positive regulation of gene expression;GO:0032956 regulation of actin cytoskeleton organization;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3HS83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08781-1", "uniprot_id": [ { "id": "ZMAT3_RAT", "url": "https://www.uniprot.org/uniprot/O08781", "type": "external" } ], "mass": 31918.0, "length": 289, "protein_name": "Zinc finger matrin-type protein 3", "gene_name": "Zmat3", "organism": "Rat", "refseq_name": "zinc finger matrin-type protein 3", "refseq_ac": [ { "id": "NP_071993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071993", "type": "external" } ], "gene_names_uniprotkb": "Zmat3; Pag608; Wig1", "gene_names_refseq": "PAG608; Wig1; Zmat3", "protein_names_uniprotkb": "Zinc finger matrin-type protein 3; Zinc finger protein WIG-1; p53-activated gene 608 protein", "protein_names_refseq": "p53 target zinc finger protein; p53-activated gene 608 protein; wild-type p53-induced gene 1; zinc finger matrin-type protein 3; zinc finger protein WIG-1", "tax_id": 10116, "disease": "", "pathway": " (rno:64394)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12196512;17234339;18242749;9250682", "class_list": "", "function": "Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Methamphetamine neurotoxicity in monoaminergic cells is related, at least in part, to induction of PAG608 expression., [RefSeq, PubMed]; PAG608 may induce or regulate p53 expression and translocate to the nucleus and nucleolus using its first zinc finger domain during oxidative stress-induced apoptosis of catecholamine-containing cells., [RefSeq, PubMed]; The specific induction of PAG608 6-48h after L-DOPA injection in the extrapyramidal tracts, pyramidal tracts and corresponding lower motor neurons of the spinal cords suggests its involvement in molecular events in stimulated motor neurons., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O08781-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63357-1", "uniprot_id": [ { "id": "MYO1D_RAT", "url": "https://www.uniprot.org/uniprot/Q63357", "type": "external" } ], "mass": 116095.0, "length": 1006, "protein_name": "Unconventional myosin-Id", "gene_name": "Myo1d", "organism": "Rat", "refseq_name": "unconventional myosin-Id", "refseq_ac": [ { "id": "NP_037115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037115", "type": "external" } ], "gene_names_uniprotkb": "Myo1d; Myr4", "gene_names_refseq": "Myo1c; Myo1d; Myr2; Myr4", "protein_names_uniprotkb": "Unconventional myosin-Id; Myosin heavy chain myr 4", "protein_names_refseq": "Unconventional myosin from rat 4 for myosin I heavy chain; myosin 1C; myosin IC; myosin heavy chain myr 4; myosin-Id; myosin1C; unconventional myosin-Id", "tax_id": 10116, "disease": "", "pathway": " (rno:25485)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12486594;12719468;15014434;15853803;24903835;26446290;30139971;8034741", "class_list": "", "function": "At apical surfaces of supporting cells surrounding hair cells in auditory epithelia of postnatal rats. In vestibular epithelia, in a ring within apical pole of hair cell. Prominent only immediately after birth., [RefSeq, PubMed]; Results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load., [RefSeq, PubMed]; This study demonistrated that myosin ID is expressed in myelinating oligodendrocytes in rat nerve system., [RefSeq, PubMed]; Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:12719468, PubMed:15853803). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (PubMed:26446290)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Unconventional myosin that functions as actin-based motor protein with ATPase activity. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes. Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQU2", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030900 forebrain development;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63357-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C606-1", "uniprot_id": [ { "id": "SGF29_RAT", "url": "https://www.uniprot.org/uniprot/P0C606", "type": "external" } ], "mass": 33268.0, "length": 293, "protein_name": "SAGA-associated factor 29", "gene_name": "Sgf29", "organism": "Rat", "refseq_name": "SAGA-associated factor 29 isoform a", "refseq_ac": [ { "id": "NP_001385682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385682", "type": "external" } ], "gene_names_uniprotkb": "Sgf29; Ccdc101", "gene_names_refseq": "Ccdc101; RGD1310609; Sgf29", "protein_names_uniprotkb": "SAGA-associated factor 29; Coiled-coil domain-containing protein 101; SAGA complex-associated factor 29; rSGF29", "protein_names_refseq": "SAGA-associated factor 29 homolog; SAGA-associated factor 29 isoform a; coiled-coil domain containing 101; coiled-coil domain-containing protein 101; rSGF29", "tax_id": 10116, "disease": "diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:293488); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17334388;23893245", "class_list": "", "function": "Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-491' (By similarity). May be involved in MYC-mediated oncogenic transformation (PubMed:17334388)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Data show that Sry is involved in male-specific malignant conversion of rodent hepatocellular carcinoma via Sgf29 upregulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140034 methylation-dependent protein binding;GO:0140002 histone H3K4me3 reader activity;GO:0140003 histone H3K36me3 reader activity", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000124 SAGA complex;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C606-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88943-1", "uniprot_id": [ { "id": "KCNQ2_RAT", "url": "https://www.uniprot.org/uniprot/O88943", "type": "external" } ], "mass": 93949.0, "length": 852, "protein_name": "Potassium voltage-gated channel subfamily KQT member 2", "gene_name": "Eef1a1l1; Eef1a2; Kcnq2", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily KQT member 2", "refseq_ac": [ { "id": "NP_579856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579856", "type": "external" } ], "gene_names_uniprotkb": "Eef1a1l1; Eef1a2; Kcnq2; Eef1a1l1; Eef1a1; Kcnq2; LOC100360413", "gene_names_refseq": "Kcnq2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2", "protein_names_refseq": "KQT-like 2; potassium channel subunit alpha KvLQT2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; voltage-gated potassium channel subunit Kv7.2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); dilated cardiomyopathy (Disease Ontology:DOID:12930); benign neonatal seizures (Disease Ontology:DOID:14264); epilepsy (Disease Ontology:DOID:1826); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:100360413); (rno:170848)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11038262;11230508;22673903;24349250;28793216;29393594;34318654;34502162;34785595;35858950;38219422;38843836;39192337;41549750;9836639", "class_list": "", "function": "Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats. Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain. Publication Status: Online-Only, [RefSeq, PubMed]; Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of mesial temporal lobe epilepsy., [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:11038262, PubMed:11230508, PubMed:24349250). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (By similarity). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:11230508). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (By similarity). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed:28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:11230508)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family., [RefSeq, PubMed]; The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., [RefSeq, PubMed]; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005267 potassium channel activity;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0030506 ankyrin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903701 substantia propria of cornea development;GO:0098976 excitatory chemical synaptic transmission;GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O88943-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5TKR9-1", "uniprot_id": [ { "id": "KAT6A_RAT", "url": "https://www.uniprot.org/uniprot/Q5TKR9", "type": "external" } ], "mass": 223331.0, "length": 1998, "protein_name": "Histone acetyltransferase KAT6A", "gene_name": "Kat6a", "organism": "Rat", "refseq_name": "histone acetyltransferase KAT6A", "refseq_ac": [ { "id": "NP_001094040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094040", "type": "external" } ], "gene_names_uniprotkb": "Kat6a; Moz; Myst3", "gene_names_refseq": "Kat6a; Moz; Myst3; Runxbp2; Znf220", "protein_names_uniprotkb": "Histone acetyltransferase KAT6A; 2.3.1.48; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MOZ; MYST-3; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein", "protein_names_refseq": "K(lysine) acetyltransferase 6A; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST protein 3; MYST-3; histone acetyltransferase KAT6A; histone acetyltransferase MYST3; monocytic leukemia zinc finger homolog; monocytic leukemia zinc finger protein", "tax_id": 10116, "disease": "Arboleda-Tham syndrome (Disease Ontology:DOID:0070062); DiGeorge syndrome (Disease Ontology:DOID:11198); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:306571); (R-RNO-3214847); (R-RNO-6804758)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16641100;22673903;29393594", "class_list": "", "function": "Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (By similarity). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity). May play a role in leukemogenic gene transcription (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0043997 histone H4K12 acetyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:0035162 embryonic hemopoiesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5TKR9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35248-1", "uniprot_id": [ { "id": "SFTPD_RAT", "url": "https://www.uniprot.org/uniprot/P35248", "type": "external" } ], "mass": 37561.0, "length": 374, "protein_name": "Pulmonary surfactant-associated protein D", "gene_name": "Sftpd", "organism": "Rat", "refseq_name": "pulmonary surfactant-associated protein D precursor", "refseq_ac": [ { "id": "NP_037010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037010", "type": "external" } ], "gene_names_uniprotkb": "Sftpd; Sftp4", "gene_names_refseq": "SP-D; SPD; Sftpd", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein D; CP4; Lung surfactant protein D; PSP-D; SP-D", "protein_names_refseq": "CP4; PSP-D; lung surfactant protein D; pulmonary surfactant protein D; pulmonary surfactant-associated protein D precursor; pulmonary surfactant-associated protein D; surfactant associated protein D; surfactant, pulmonary-associated protein D", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); pre-malignant neoplasm (Disease Ontology:DOID:0060071); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); Coronavirus infectious disease (Disease Ontology:DOID:0080599); sarcoidosis (Disease Ontology:DOID:11335); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rhinitis (Disease Ontology:DOID:4483); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25350); (R-RNO-166016); (R-RNO-391160); (R-RNO-5683826); (R-RNO-5686938)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "1370483;19007302;22673903;2675969;28719181;29393594;30422021;34777371;35865531", "class_list": "", "function": "Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Polydatin significantly reduced the inflammatory mediators and restored the normal values of oxidative and nitrosative stress biomarkers. It also significantly reduced the expression of surfactant-D and UCN as compared to asthma control, [RefSeq, PubMed]; SPA binds dipalmitoyl-phosphatidylcholine, the major surfactant lipid component, but not phosphatidylinositol; SPD exhibits the opposite preference. Data suggest flexibility in a key surface loop supports distinctive lipid binding of SPA; quadruple mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like loop-stabilizing Ca2+ binding site in carbohydrate recognition domain exhibits ligand-binding preferences of SPD., [RefSeq, PubMed]; Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001530 lipopolysaccharide binding;GO:0048029 monosaccharide binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005771 multivesicular body;GO:0005576 extracellular region", "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0048286 lung alveolus development;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35248-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJQ4-1", "uniprot_id": [ { "id": "SIR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJQ4", "type": "external" } ], "mass": 39319.0, "length": 350, "protein_name": "NAD-dependent protein deacetylase sirtuin-2", "gene_name": "Sirt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sirt2; Sir2l2", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-2; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); high grade glioma (Disease Ontology:DOID:3070); intermittent claudication (Disease Ontology:DOID:3669); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:361532); (R-RNO-2995383)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12065666;17344398;21949390;22673903;22943040", "class_list": "", "function": "NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:17344398). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes. Positively regulates the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase complex activity by deacetylating CDC20 and FZR1, then allowing progression through mitosis. Associates both with chromatin at transcriptional start sites (TSSs) and enhancers of active genes. Plays a role in cell cycle and chromatin compaction through epigenetic modulation of the regulation of histone H4 'Lys-20' methylation (H4K20me1) during early mitosis. Specifically deacetylates histone H4 at 'Lys-16' (H4K16ac) between the G2/M transition and metaphase enabling H4K20me1 deposition by KMT5A leading to ulterior levels of H4K20me2 and H4K20me3 deposition throughout cell cycle, and mitotic S-phase progression. Deacetylates KMT5A modulating KMT5A chromatin localization during the mitotic stress response. Also deacetylates histone H3 at 'Lys-57' (H3K56ac) during the mitotic G2/M transition. During oocyte meiosis progression, may deacetylate histone H4 at 'Lys-16' (H4K16ac) and alpha-tubulin, regulating spindle assembly and chromosome alignment by influencing microtubule dynamics and kinetochore function. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter and thereby contributes to regulate expression of VEGFA, a key regulator of angiogenesis. Deacetylates alpha-tubulin at 'Lys-40' and hence controls neuronal motility, oligodendroglial cell arbor projection processes and proliferation of non-neuronal cells. Phosphorylation at Ser-368 by a G1/S-specific cyclin E-CDK2 complex inactivates SIRT2-mediated alpha-tubulin deacetylation, negatively regulating cell adhesion, cell migration and neurite outgrowth during neuronal differentiation. Deacetylates PARD3 and participates in the regulation of Schwann cell peripheral myelination formation during early postnatal development and during postinjury remyelination. Involved in several cellular metabolic pathways. Plays a role in the regulation of blood glucose homeostasis by deacetylating and stabilizing phosphoenolpyruvate carboxykinase PCK1 activity in response to low nutrient availability. Acts as a key regulator in the pentose phosphate pathway (PPP) by deacetylating and activating the glucose-6-phosphate G6PD enzyme, and therefore, stimulates the production of cytosolic NADPH to counteract oxidative damage. Maintains energy homeostasis in response to nutrient deprivation as well as energy expenditure by inhibiting adipogenesis and promoting lipolysis. Attenuates adipocyte differentiation by deacetylating and promoting FOXO1 interaction to PPARG and subsequent repression of PPARG-dependent transcriptional activity. Plays a role in the regulation of lysosome-mediated degradation of protein aggregates by autophagy in neuronal cells. Deacetylates FOXO1 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagy (By similarity). Deacetylates a broad range of transcription factors and co-regulators regulating target gene expression. Deacetylates transcriptional factor FOXO3 stimulating the ubiquitin ligase SCF(SKP2)-mediated FOXO3 ubiquitination and degradation (By similarity). Deacetylates HIF1A and therefore promotes HIF1A degradation and inhibition of HIF1A transcriptional activity in tumor cells in response to hypoxia. Deacetylates RELA in the cytoplasm inhibiting NF-kappaB-dependent transcription activation upon TNF stimulation. Inhibits transcriptional activation by deacetylating p53/TP53 and EP300. Also deacetylates EIF5A. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of N(6)-benzoyl (benzoyl) and N(6)-methacryl (methacryl) acyl groups from lysine residues, leading to histone debenzoylation and demethacrylation, respectively (By similarity). Functions as a negative regulator on oxidative stress-tolerance in response to anoxia-reoxygenation conditions. Plays a role as tumor suppressor (PubMed:22943040). In addition to protein deacetylase activity, also has activity toward long-chain fatty acyl groups and mediates protein-lysine demyristoylation and depalmitoylation of target proteins, such as ARF6 and KRAS, thereby regulating their association with membranes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; NAD-dependent protein deacetylase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0046970 histone H4K16 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0061433 cellular response to caloric restriction;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RJQ4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6X936-1", "uniprot_id": [ { "id": "KIRR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6X936", "type": "external" } ], "mass": 87241.0, "length": 789, "protein_name": "Kin of IRRE-like protein 1", "gene_name": "Kirrel1", "organism": "Rat", "refseq_name": "kin of IRRE-like protein 1 precursor", "refseq_ac": [ { "id": "NP_997489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997489", "type": "external" } ], "gene_names_uniprotkb": "Kirrel1; Kirrel; Neph1", "gene_names_refseq": "Kirrel1; Kirrel; Neph1", "protein_names_uniprotkb": "Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1", "protein_names_refseq": "kin of IRRE like 1; kin of IRRE-like protein 1 precursor; kin of IRRE-like protein 1; kin of irregular chiasm-like protein 1; nephrin 1; nephrin-like protein 1", "tax_id": 10116, "disease": "nephrotic syndrome type 23 (Disease Ontology:DOID:0112266); nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:310695); (R-RNO-373753)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12646566;12865409;15979540;18258597;21277866;23570724;25298195", "class_list": "", "function": "Fetal membranes and placenta of the rat express mRNA for the protein barriers nephrin and Neph 1, suggesting a role in the regulation of protein transfer from the fetus to mother, [RefSeq, PubMed]; Irbesartan treatment ameliorates proteinuria in puromycin aminonucleoside nephropathy by inhibiting the reduction of NEPH1 and nephrin in the kidney glomerulus., [RefSeq, PubMed]; Nephrin and Neph1 form a hetero-oligomeric receptor complex in the plane of the membrane that might interact across the foot process intercellular junction through interactions between Nephrin with itself and Neph1, [RefSeq, PubMed]; Nephrin and Neph1 interact and have roles in glomerular permeability, [RefSeq, PubMed]; RKirre may play a potential role in postnatal developing rat cerebellum., [RefSeq, PubMed]; Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (By similarity). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity)., [UniProtKB, UniProtKB]; These results suggested that rKirre might play an essential role in neuronal differentiation and development in the central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "F1M7V1;Q80W67", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0043198 dendritic shaft;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0097017 renal protein absorption;GO:0001933 negative regulation of protein phosphorylation;GO:0098609 cell-cell adhesion;GO:0030838 positive regulation of actin filament polymerization;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6X936-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP36-1", "uniprot_id": [ { "id": "SHRM2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP36", "type": "external" } ], "mass": 157989.0, "length": 1423, "protein_name": "Protein Shroom2", "gene_name": "Shroom2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Shroom2; Ab2-404; Apxl", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Shroom2; Liver regeneration-related protein LRRG167; Protein Apxl", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:317435)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0051015 actin filament binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0030835 negative regulation of actin filament depolymerization;GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0032438 melanosome organization;GO:0045217 cell-cell junction maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TP36-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR1-1", "uniprot_id": [ { "id": "INP5E_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVR1", "type": "external" } ], "mass": 72040.0, "length": 648, "protein_name": "Phosphatidylinositol polyphosphate 5-phosphatase type IV", "gene_name": "Inpp5e", "organism": "Rat", "refseq_name": "phosphatidylinositol polyphosphate 5-phosphatase type IV", "refseq_ac": [ { "id": "NP_446084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446084", "type": "external" } ], "gene_names_uniprotkb": "Inpp5e", "gene_names_refseq": "Inpp5e", "protein_names_uniprotkb": "Phosphatidylinositol polyphosphate 5-phosphatase type IV; 3.1.3.36; 3.1.3.86; 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; Pharbin; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase", "protein_names_refseq": "5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; pharbin; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); Joubert syndrome 1 (Disease Ontology:DOID:0110980); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:114089); (R-RNO-1660514); (R-RNO-5624958)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10405344;21436142;22673903", "class_list": "", "function": "Pharbin is an important negative regulator of IGF-1/PI3K/Akt signalling and protein synthesis., [RefSeq, PubMed]; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate PtdIns (4,5)P2 and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10405344). Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K6T4", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" } ], "go_molecular_function": "GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity;GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0060271 cilium assembly;GO:0017148 negative regulation of translation;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0046856 phosphatidylinositol dephosphorylation;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WVR1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZU82-1", "uniprot_id": [ { "id": "GOGA5_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZU82", "type": "external" } ], "mass": 82334.0, "length": 728, "protein_name": "Golgin subfamily A member 5", "gene_name": "Golga5", "organism": "Rat", "refseq_name": "golgin subfamily A member 5", "refseq_ac": [ { "id": "NP_001028237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028237", "type": "external" } ], "gene_names_uniprotkb": "Golga5", "gene_names_refseq": "Golga5; Ret-II", "protein_names_uniprotkb": "Golgin subfamily A member 5; Golgin-84", "protein_names_refseq": "golgi autoantigen, golgin subfamily a, 5; golgin subfamily A member 5; golgin-84", "tax_id": 10116, "disease": "", "pathway": " (rno:299258)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12656988;15047867;15718469;22673903;27502188", "class_list": "", "function": "Characterization of the golgin-84-CASP tether binding to coat protein complex I (COPI) vesicles, [RefSeq, PubMed]; Golgin-84 (Golga5) involved in generating and maintaining the architecture of the Golgi apparatus., [RefSeq, PubMed]; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005797 Golgi medial cisterna;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport;GO:0000301 retrograde transport, vesicle recycling within Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3ZU82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1P7-1", "uniprot_id": [ { "id": "SMCA4_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1P7", "type": "external" } ], "mass": 181427.0, "length": 1613, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4", "gene_name": "Smarca4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smarca4; Baf190a; Brg1; Snf2b; Snf2l4", "gene_names_refseq": "", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; 3.6.4.-; BAF190A; BRG1-associated factor 190A; Protein brahma homolog 1; SMARCA4; SNF2-beta; Transcription activator BRG1", "protein_names_refseq": "", "tax_id": 10116, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); rhabdoid tumor predisposition syndrome 2 (Disease Ontology:DOID:0060997); Coffin-Siris syndrome 4 (Disease Ontology:DOID:0070046); Nicolaides-Baraitser syndrome (Disease Ontology:DOID:0081441); prostate cancer (Disease Ontology:DOID:10283); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (R-RNO-1266695); (R-RNO-201722); (R-RNO-3214858); (R-RNO-3247509); (R-RNO-8939243); (R-RNO-9764725); (R-RNO-9933937); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9933947); (R-RNO-9934037)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "19081374;22673903", "class_list": "", "function": "ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:19081374). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (PubMed:19081374). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016514 SWI/SNF complex", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1902661 positive regulation of glucose mediated signaling pathway;GO:0060318 definitive erythrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K1P7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ2-1", "uniprot_id": [ { "id": "LRC46_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ2", "type": "external" } ], "mass": 36003.0, "length": 323, "protein_name": "Leucine-rich repeat-containing protein 46", "gene_name": "Lrrc46", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 46", "refseq_ac": [ { "id": "NP_001004201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004201", "type": "external" } ], "gene_names_uniprotkb": "Lrrc46", "gene_names_refseq": "Lrrc46", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 46", "protein_names_refseq": "leucine-rich repeat-containing protein 46", "tax_id": 10116, "disease": "", "pathway": " (rno:287653)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for normal spermatogenesis and male fertility. Plays an important role in sperm flagellum biogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0097225 sperm midpiece;GO:0031514 motile cilium", "go_biological_process": "GO:0098727 maintenance of cell number;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09456-1", "uniprot_id": [ { "id": "KAP0_RAT", "url": "https://www.uniprot.org/uniprot/P09456", "type": "external" } ], "mass": 43095.0, "length": 381, "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "Prkar1a", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "refseq_ac": [ { "id": "NP_037313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037313", "type": "external" } ], "gene_names_uniprotkb": "Prkar1a", "gene_names_refseq": "Prkar1a; RIIA", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "protein_names_refseq": "cAMP-dependent protein kinase type I-alpha regulatory subunit; protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha", "tax_id": 10116, "disease": "Carney complex (Disease Ontology:DOID:0050471); primary pigmented nodular adrenocortical disease (Disease Ontology:DOID:0060280); primary pigmented nodular adrenocortical disease 1 (Disease Ontology:DOID:0070546); acrodysostosis (Disease Ontology:DOID:14669); follicular thyroid carcinoma (Disease Ontology:DOID:3962)", "pathway": " (rno:25725); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-432040); (R-RNO-442720); (R-RNO-5610787); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9856530)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "11818504;22673903;25587115;29393594;3619906", "class_list": "", "function": "CAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes, [RefSeq, PubMed]; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0019904 protein domain specific binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0010629 negative regulation of gene expression;GO:0071377 cellular response to glucagon stimulus;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12369-1", "uniprot_id": [ { "id": "KAP3_RAT", "url": "https://www.uniprot.org/uniprot/P12369", "type": "external" } ], "mass": 46123.0, "length": 416, "protein_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "gene_name": "Prkar2b", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase type II-beta regulatory subunit", "refseq_ac": [ { "id": "NP_001025191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025191", "type": "external" } ], "gene_names_uniprotkb": "Prkar2b", "gene_names_refseq": "Prkar2b; RATDNA", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II-beta regulatory subunit", "protein_names_refseq": "Type II beta regulatory subunit of cAMP-dependent protein kinase; cAMP-dependent protein kinase type II-beta regulatory subunit; protein kinase cAMP-dependent type 2 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta", "tax_id": 10116, "disease": "malaria (Disease Ontology:DOID:12365); granulosa cell tumor (Disease Ontology:DOID:2999)", "pathway": " (rno:24679); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-432040); (R-RNO-442720); (R-RNO-5610787); (R-RNO-5620912); (R-RNO-8854518); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9856530)", "pathway_count": 17, "publication_count": 9, "publication_id_list": "11342137;16641100;21423175;22323819;22673903;2427518;25112875;26158466;3401231", "class_list": "", "function": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB]; Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. Publication Status: Online-Only, [RefSeq, PubMed]; Study describes the 2.3 angstrom structure of full-length tetrameric RIIbeta(2):C(2) holoenzyme, [RefSeq, PubMed]; The unique structural properties of RiIbeta do not require the C-terminal cAMP-binding domain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007612 learning;GO:0050804 modulation of chemical synaptic transmission;GO:0045859 regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P12369-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52631-1", "uniprot_id": [ { "id": "STAT3_RAT", "url": "https://www.uniprot.org/uniprot/P52631", "type": "external" } ], "mass": 88040.0, "length": 770, "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "Stat3", "organism": "Rat", "refseq_name": "signal transducer and activator of transcription 3 isoform 1", "refseq_ac": [ { "id": "NP_036879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036879", "type": "external" } ], "gene_names_uniprotkb": "Stat3", "gene_names_refseq": "Stat3", "protein_names_uniprotkb": "Signal transducer and activator of transcription 3", "protein_names_refseq": "signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3 isoform 1", "tax_id": 10116, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); inflammatory bowel disease (Disease Ontology:DOID:0050589); pre-malignant neoplasm (Disease Ontology:DOID:0060071); chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); infantile onset multisystem autoimmune disease 1 (Disease Ontology:DOID:0061160); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); neutropenia (Disease Ontology:DOID:1227); Behcet's disease (Disease Ontology:DOID:13241); breast cancer (Disease Ontology:DOID:1612); duodenal ulcer (Disease Ontology:DOID:1724); squamous cell carcinoma (Disease Ontology:DOID:1749); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); rectum adenocarcinoma (Disease Ontology:DOID:1996); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); Churg-Strauss syndrome (Disease Ontology:DOID:3049); glioblastoma (Disease Ontology:DOID:3068); autosomal dominant hyper-IgE syndrome 1 with recurrent infections (Disease Ontology:DOID:3261); angiomyolipoma (Disease Ontology:DOID:3314); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); psoriatic arthritis (Disease Ontology:DOID:9008); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); peripartum cardiomyopathy (Disease Ontology:DOID:9997)", "pathway": " (rno:25125); (R-RNO-1059683); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-186763); (R-RNO-201556); (R-RNO-6783783); (R-RNO-6785807); (R-RNO-8849474); (R-RNO-8854691); (R-RNO-8875791); (R-RNO-8983432); (R-RNO-8984722); (R-RNO-8985947); (R-RNO-9008059); (R-RNO-9020933); (R-RNO-9020956); (R-RNO-9020958); (R-RNO-9701898); (R-RNO-9833482); (R-RNO-9958825)", "pathway_count": 21, "publication_count": 104, "publication_id_list": "10707961;10762348;10770494;10891587;11421584;11960596;12087100;12487370;12695539;15187153;15361284;16225866;16263078;16413512;16611639;16905269;17131417;17525119;18411006;18798867;19249349;19299911;19427337;19538478;20209132;20227492;20960209;21223972;21285325;21612602;21738764;21858029;22025881;22076135;22668509;22889746;22948409;23146666;23268184;23437066;23466243;23533474;23573126;24041262;24098399;24152426;24199834;24251112;24260264;24582310;24769234;24976155;25088002;25105067;25602782;25731682;25931810;25997003;26131716;26144579;26155847;26202747;26417930;26420542;26471891;26773188;26858089;26872211;27094369;27101310;27406600;27677620;27832152;28686615;28923114;29050872;29393594;29605530;29943847;30622968;30632310;30649810;30816520;30858408;31165412;31583053;31848475;32190173;32482054;32531698;32722178;33272194;33594167;33628191;33731692;35125963;35322092;35620576;38154546;38306778;38733520;38796983;8530402;9813052", "class_list": "", "function": "Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation., [RefSeq, PubMed]; IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction., [RefSeq, PubMed]; STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells., [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0048708 astrocyte differentiation;GO:2001171 positive regulation of ATP biosynthetic process;GO:1905564 positive regulation of vascular endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 10.5, "record_id": "P52631-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68182-1", "uniprot_id": [ { "id": "KAPCB_RAT", "url": "https://www.uniprot.org/uniprot/P68182", "type": "external" } ], "mass": 40708.0, "length": 351, "protein_name": "cAMP-dependent protein kinase catalytic subunit beta", "gene_name": "Prkacb", "organism": "Rat", "refseq_name": "cAMP-dependent protein kinase catalytic subunit beta isoform 1", "refseq_ac": [ { "id": "NP_001071113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071113", "type": "external" } ], "gene_names_uniprotkb": "Prkacb; Pkacb", "gene_names_refseq": "Prkacb", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit beta; 2.7.11.11; PKA C-beta", "protein_names_refseq": "PKA C-beta; cAMP-dependent protein kinase catalytic subunit beta isoform 1; cAMP-dependent protein kinase catalytic subunit beta; protein kinase, cAMP dependent, catalytic, beta; protein kinase, cAMP-dependent, beta catalytic subunit", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:293508); (R-RNO-163615); (R-RNO-164378); (R-RNO-180024); (R-RNO-381676); (R-RNO-392517); (R-RNO-422356); (R-RNO-432040); (R-RNO-4420097); (R-RNO-442720); (R-RNO-5610785); (R-RNO-5610787); (R-RNO-5621575); (R-RNO-5687128); (R-RNO-8853659); (R-RNO-8963896); (R-RNO-9634597); (R-RNO-983231); (R-RNO-9856530)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "1610898;18683930;22673903;29393594;9521123", "class_list": "", "function": "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05206", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0001843 neural tube closure;GO:0051447 negative regulation of meiotic cell cycle;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P68182-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97924-1", "uniprot_id": [ { "id": "KALRN_RAT", "url": "https://www.uniprot.org/uniprot/P97924", "type": "external" } ], "mass": 336587.0, "length": 2959, "protein_name": "Kalirin", "gene_name": "Kalrn", "organism": "Rat", "refseq_name": "kalirin", "refseq_ac": [ { "id": "NP_114451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114451", "type": "external" } ], "gene_names_uniprotkb": "Kalrn; Duo; Hapip", "gene_names_refseq": "Duo; Hapip; Kalirin; Kalrn", "protein_names_uniprotkb": "Kalirin; 2.7.11.1; Huntingtin-associated protein-interacting protein; P-CIP10; PAM COOH-terminal interactor protein 10; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain", "protein_names_refseq": "P-CIP10; PAM COOH-terminal interactor protein 10; cyclin B1; huntingtin-associated protein interacting protein (duo); huntingtin-associated protein-interacting protein; kalirin; protein Duo; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain", "tax_id": 10116, "disease": "cerebral atherosclerosis (Disease Ontology:DOID:12720); epilepsy (Disease Ontology:DOID:1826); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (rno:84009); (R-RNO-193648); (R-RNO-3928662); (R-RNO-416476); (R-RNO-416482); (R-RNO-5687128); (R-RNO-8980692); (R-RNO-9013149); (R-RNO-9013408)", "pathway_count": 9, "publication_count": 13, "publication_id_list": "10692441;10777487;11606631;15950621;16644733;22673903;30565792;30875016;32375403;38143048;8910496;9139723;9285789", "class_list": "", "function": "Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Publication Status: Online-Only, [RefSeq, PubMed]; Our results suggest that kalirin-7 may play a role in the early events leading to synapse degeneration, [RefSeq, PubMed]; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation., [UniProtKB, PubMed, PubMed, PubMed]; Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin., [RefSeq, PubMed]; That Cdk5 affects the function of Kal-7 on spine morphology and function via GluN2B and GluA1 receptors during dendritic spine formation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70135;Q6IV51;Q9JIF1;Q9JIF2;Q9JIG0;Q9JIH3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0046959 habituation;GO:0060125 negative regulation of growth hormone secretion;GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P97924-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK61-1", "uniprot_id": [ { "id": "SNX20_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK61", "type": "external" } ], "mass": 35723.0, "length": 313, "protein_name": "Sorting nexin-20", "gene_name": "Snx20", "organism": "Rat", "refseq_name": "sorting nexin-20", "refseq_ac": [ { "id": "NP_001020170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020170", "type": "external" } ], "gene_names_uniprotkb": "Snx20", "gene_names_refseq": "RGD1307787; Slic1; Snx20", "protein_names_uniprotkb": "Sorting nexin-20", "protein_names_refseq": "selectin ligand interactor cytoplasmic-1; sorting nexin-20", "tax_id": 10116, "disease": "", "pathway": " (rno:307742)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BK61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPJ9-1", "uniprot_id": [ { "id": "SHLB2_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPJ9", "type": "external" } ], "mass": 44853.0, "length": 404, "protein_name": "Endophilin-B2", "gene_name": "Sh3glb2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sh3glb2", "gene_names_refseq": "", "protein_names_uniprotkb": "Endophilin-B2; SH3 domain-containing GRB2-like protein B2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-264870); (R-RNO-6794361); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18683930;22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0098843 postsynaptic endocytic zone", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006897 endocytosis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PPJ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQM2-1", "uniprot_id": [ { "id": "KLC4_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQM2", "type": "external" } ], "mass": 68964.0, "length": 619, "protein_name": "Kinesin light chain 4", "gene_name": "Klc4", "organism": "Rat", "refseq_name": "kinesin light chain 4", "refseq_ac": [ { "id": "NP_001009601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009601", "type": "external" } ], "gene_names_uniprotkb": "Klc4; Knsl8", "gene_names_refseq": "1200014p03rik; Klc4; Knsl8", "protein_names_uniprotkb": "Kinesin light chain 4; KLC 4; Kinesin-like protein 8", "protein_names_refseq": "KLC 4; kinesin light chain 4; kinesin-like 8; kinesin-like protein 8", "tax_id": 10116, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348)", "pathway": " (rno:316226); (R-RNO-2132295); (R-RNO-5625970); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI06-1", "uniprot_id": [ { "id": "KAT8_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI06", "type": "external" } ], "mass": 52632.0, "length": 458, "protein_name": "Histone acetyltransferase KAT8", "gene_name": "Kat8", "organism": "Rat", "refseq_name": "histone acetyltransferase KAT8", "refseq_ac": [ { "id": "NP_001017378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017378", "type": "external" } ], "gene_names_uniprotkb": "Kat8; Myst1", "gene_names_refseq": "Kat8; Myst1", "protein_names_uniprotkb": "Histone acetyltransferase KAT8; 2.3.1.-; 2.3.1.48; Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; Protein acetyltransferase KAT8; Protein propionyltransferase KAT8", "protein_names_refseq": "K (lysine) acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST histone acetyltransferase 1; MYST protein 1; MYST-1; histone acetyltransferase KAT8; probable histone acetyltransferase MYST1; protein acetyltransferase KAT8; protein propionyltransferase KAT8", "tax_id": 10116, "disease": "", "pathway": " (rno:310194); (R-RNO-3214847); (R-RNO-9772755)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context. Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (By similarity). H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism (By similarity). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). As part of the NSL histone acetyltransferase complex, catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. The NSL complex also acts as a regulator of gene expression in mitochondria: KAT8 associates with mitochondrial DNA and controls expression of respiratory genes in an acetyltransferase-dependent mechanism. Also functions as an acetyltransferase for non-histone targets, such as ALKBH5, COX17, IRF3, KDM1A/LSD1, LMNA, PAX7 or TP53/p53 (By similarity). Acts as an inhibitor of antiviral immunity by acetylating IRF3, preventing IRF3 recruitment to promoters. Acts as a regulator of asymmetric division in muscle stem cells by mediating acetylation of PAX7 (By similarity). As part of the NSL complex, acetylates TP53/p53 at 'Lys-120'. Acts as a regulator of epithelial-to-mesenchymal transition as part of the NSL complex by mediating acetylation of KDM1A/LSD1 (By similarity). The NSL complex is required for nuclear architecture maintenance by mediating acetylation of LMNA. Promotes mitochondrial integrity by catalyzing acetylation of COX17 (By similarity). In addition to protein acetyltransferase activity, able to mediate protein propionylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0061920 protein propionyltransferase activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0035267 NuA4 histone acetyltransferase complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0010506 regulation of autophagy;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924A5-1", "uniprot_id": [ { "id": "S36A1_RAT", "url": "https://www.uniprot.org/uniprot/Q924A5", "type": "external" } ], "mass": 52569.0, "length": 475, "protein_name": "Proton-coupled amino acid transporter 1", "gene_name": "Slc36a1", "organism": "Rat", "refseq_name": "proton-coupled amino acid transporter 1", "refseq_ac": [ { "id": "NP_569099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569099", "type": "external" } ], "gene_names_uniprotkb": "Slc36a1; Lyaat1", "gene_names_refseq": "Lyaat1; Slc36a1", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 1; LYAAT-1; Lysosomal amino acid transporter 1; Neutral amino acid/proton symporter; Proton/amino acid transporter 1; Solute carrier family 36 member 1", "protein_names_refseq": "LYAAT-1; lysosomal amino acid transporter 1; neutral amino acid/proton symporter; proton-coupled amino acid transporter 1; proton/amino acid transporter 1; solute carrier family 36 (proton/amino acid symporter), member 1; ysosomal amino acid transporter 1", "tax_id": 10116, "disease": "", "pathway": " (rno:155205); (R-RNO-352230); (R-RNO-428559)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11390972;12598615;18496516;22234618;23962042;24016666;24222668", "class_list": "", "function": "Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:11390972, PubMed:12598615). May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (PubMed:12598615). May play a role in specifying sites for exocytosis in neurons (PubMed:12598615)., [UniProtKB, PubMed, PubMed]; Expression of proton-assisted amino acid transporter 1 (PAT1) mRNA was slightly but not significantly induced by a single bout of exercise in soleus and extensor digitorum longus muscles., [RefSeq, PubMed]; Knockdown of (PAT1) led to induced cellular growth, suggesting a role for PAT1 in regulating cellular proliferation of smooth muscle cells, [RefSeq, PubMed]; PAT1(Slc36a1) protein was present in rat rectal epithelium., [RefSeq, PubMed]; Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport., [RefSeq, PubMed]; The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons., [RefSeq, PubMed]; The essential role of chloride and fructose absorbing Slc36a1 is reported., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0015824 proline transport;GO:0032328 alanine transport;GO:0035524 proline transmembrane transport;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q924A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M75-1", "uniprot_id": [ { "id": "RTN4R_RAT", "url": "https://www.uniprot.org/uniprot/Q99M75", "type": "external" } ], "mass": 50851.0, "length": 473, "protein_name": "Reticulon-4 receptor", "gene_name": "Rtn4r", "organism": "Rat", "refseq_name": "reticulon-4 receptor precursor", "refseq_ac": [ { "id": "NP_446065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446065", "type": "external" } ], "gene_names_uniprotkb": "Rtn4r; Nogor", "gene_names_refseq": "NgR1; NgR; Nogor; Rtn4r", "protein_names_uniprotkb": "Reticulon-4 receptor; NgR; Nogo receptor; Nogo-66 receptor", "protein_names_refseq": "Nogo66 receptor; nogo receptor; nogo-66 receptor; reticulon-4 receptor precursor", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:113912)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11891768;12037567;12426574;15673660;18411262;19420245;20815818;22325200;24826969;26335717;28489665;31948754;32598099;33495810;35263202;38843836", "class_list": "", "function": "Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone., [RefSeq, PubMed]; Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1., [RefSeq, PubMed]; Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and Nogo-66 receptor antagonist peptide promotes axonal regeneration., [RefSeq, PubMed]; Nogo66 promotes betaamyloid protein secretion via NgR/ROCKdependent BACE1 activation., [RefSeq, PubMed]; Notoginsenoside R1 relieves the myocardial infarction via activating the JAK2/STAT3 signaling pathway in vivo and in vitro., [RefSeq, PubMed]; Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:15673660, PubMed:19420245). Functions as a receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as a receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:18411262). Mediates axonal growth inhibition (PubMed:12037567). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; This study identifies a separation of functions for the NgR-regulated WNK1 in mediating proliferation, migration and axonal extension in PC12 cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:1905573 ganglioside GM1 binding;GO:0008201 heparin binding;GO:0044877 protein-containing complex binding;GO:0035374 chondroitin sulfate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030426 growth cone", "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007409 axonogenesis;GO:0043547 positive regulation of GTPase activity;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q99M75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MK2-1", "uniprot_id": [ { "id": "KAT5_RAT", "url": "https://www.uniprot.org/uniprot/Q99MK2", "type": "external" } ], "mass": 58598.0, "length": 513, "protein_name": "Histone acetyltransferase KAT5", "gene_name": "Kat5", "organism": "Rat", "refseq_name": "histone acetyltransferase KAT5", "refseq_ac": [ { "id": "NP_001005872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005872", "type": "external" } ], "gene_names_uniprotkb": "Kat5; Htatip; Tip60b; Tip60", "gene_names_refseq": "Htatip1; Htatip; Kat5; Tip60", "protein_names_uniprotkb": "Histone acetyltransferase KAT5; 2.3.1.-; 2.3.1.48; 60 kDa Tat-interactive protein; Histone acetyltransferase HTATIP; Lysine acetyltransferase 5; Protein 2-hydroxyisobutyryltransferase KAT5; Protein acetyltransferase KAT5; Protein crotonyltransferase KAT5; Protein lactyltransferase KAT5; Tip60", "protein_names_refseq": "60 kDa Tat-interactive protein; HIV-1 Tat interactive protein, 60 kD; HIV-1 tat interactive protein, homolog; K(lysine) acetyltransferase 5; histone acetyltransferase HTATIP; histone acetyltransferase KAT5; protein 2-hydroxyisobutyryltransferase KAT5; protein acetyltransferase KAT5; protein crotonyltransferase KAT5; protein lactyltransferase KAT5", "tax_id": 10116, "disease": "iron deficiency anemia (Disease Ontology:DOID:11758); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:192218); (R-RNO-2559586); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5693548); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473); (R-RNO-9018519)", "pathway_count": 15, "publication_count": 6, "publication_id_list": "11441186;12414113;19282473;23059819;24075908;27454757", "class_list": "", "function": "Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognizes and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyzes acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks. Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage (By similarity). The NuA4 complex plays a key role in hematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes. The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone hyperacetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as BMAL1, ATM, AURKB, CHKA, CGAS, ERCC4/XPF, LPIN1, TP53/p53, NDC80/HEC1, NR1D2, RAN, SOX4, FOXP3, SQSTM1, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Promotes nucleotide excision repair (NER) by mediating acetylation of ERCC4/XPF, thereby promoting formation of the ERCC4-ERCC1 complex. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Acts as a regulator of regulatory T-cells (Treg) by catalyzing FOXP3 acetylation, thereby promoting FOXP3 transcriptional repressor activity. Involved in skeletal myoblast differentiation by mediating acetylation of SOX4. Catalyzes acetylation of APBB1/FE65, increasing its transcription activator activity (By similarity). Promotes transcription elongation during the activation phase of the circadian cycle by catalyzing acetylation of BMAL1, promoting elongation of circadian transcripts (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Acts as a regulator of the cGAS-STING innate antiviral response by catalyzing acetylation the N-terminus of CGAS, thereby promoting CGAS DNA-binding and activation. Also regulates lipid metabolism by mediating acetylation of CHKA or LPIN1. Promotes lipolysis of lipid droplets following glucose deprivation by mediating acetylation of isoform 1 of CHKA, thereby promoting monomerization of CHKA and its conversion into a tyrosine-protein kinase. Acts as a regulator of fatty-acid-induced triacylglycerol synthesis by catalyzing acetylation of LPIN1, thereby promoting the synthesis of diacylglycerol. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), S-lactoyl-CoA (lactyl-CoA) and 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), and is able to mediate protein crotonylation, lactylation and 2-hydroxyisobutyrylation, respectively. Acts as a key regulator of chromosome segregation and kinetochore-microtubule attachment during mitosis by mediating acetylation or crotonylation of target proteins. Catalyzes acetylation of AURKB at kinetochores, increasing AURKB activity and promoting accurate chromosome segregation in mitosis. Acetylates RAN during mitosis, promoting microtubule assembly at mitotic chromosomes. Acetylates NDC80/HEC1 during mitosis, promoting robust kinetochore-microtubule attachment. Catalyzes crotonylation of MAPRE1/EB1, thereby ensuring accurate spindle positioning in mitosis. Catalyzes lactylation of NBN/NBS1 in response to DNA damage, thereby promoting DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Insulin activates prolactin gene transcription by activating Elk-1 that recruits the NuA4 complex to the promoter., [RefSeq, PubMed]; Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. Publication Status: Online-Only, [RefSeq, PubMed]; The neurotoxic effects of HIV-1 Tat are mediated, in part, by direct interactions with a polyamine-sensitive site on the NMDA receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XI16", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0140065 peptide butyryltransferase activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:1901985 positive regulation of protein acetylation;GO:0032703 negative regulation of interleukin-2 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99MK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PE6-1", "uniprot_id": [ { "id": "SMIM3_RAT", "url": "https://www.uniprot.org/uniprot/Q99PE6", "type": "external" } ], "mass": 6568.0, "length": 60, "protein_name": "Small integral membrane protein 3", "gene_name": "Smim3", "organism": "Rat", "refseq_name": "small integral membrane protein 3", "refseq_ac": [ { "id": "NP_775149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775149", "type": "external" } ], "gene_names_uniprotkb": "Smim3; Nid67", "gene_names_refseq": "Nid67; Smim3", "protein_names_uniprotkb": "Small integral membrane protein 3; NGF-induced differentiation clone 67 protein; Small membrane protein NID67", "protein_names_refseq": "NGF-induced differentiation clone 67 protein; putative small membrane protein NID67; small integral membrane protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:286910)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11288140;26479776", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99PE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06536-1", "uniprot_id": [ { "id": "GCR_RAT", "url": "https://www.uniprot.org/uniprot/P06536", "type": "external" } ], "mass": 87556.0, "length": 795, "protein_name": "Glucocorticoid receptor", "gene_name": "Nr3c1", "organism": "Rat", "refseq_name": "glucocorticoid receptor", "refseq_ac": [ { "id": "NP_036708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036708", "type": "external" } ], "gene_names_uniprotkb": "Nr3c1; Grl", "gene_names_refseq": "GR; Gcr; Grl; Nr3c1", "protein_names_uniprotkb": "Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1", "protein_names_refseq": "glucocorticoid receptor", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); withdrawal disorder (Disease Ontology:DOID:0060001); lupus nephritis (Disease Ontology:DOID:0080162); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); lipoid nephrosis (Disease Ontology:DOID:10966); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcoholic neuropathy (Disease Ontology:DOID:14183); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); mood disorder (Disease Ontology:DOID:3324); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); primary hyperaldosteronism (Disease Ontology:DOID:446); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); lung disease (Disease Ontology:DOID:850); anorexia nervosa (Disease Ontology:DOID:8689); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24413); (R-RNO-3371497); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 4, "publication_count": 40, "publication_id_list": "10364267;10480874;10866662;11278286;11435610;12118039;12917342;15220929;16641100;1751485;1865905;1936288;1939229;19406955;19782950;2115209;21730050;22673903;23508108;23878391;25057792;25732140;27387895;3191912;3216865;33005820;3684608;37040814;3755378;37863964;38557197;8191545;8257681;8450530;8493115;8618925;9038175;9111344;9199329;9603939", "class_list": "", "function": "Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats., [RefSeq, PubMed]; Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic beta-cells. Publication Status: Online-Only, [RefSeq, PubMed]; Has transcriptional activation and repression activity. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:12917342). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). In response to induction by transcription factor EGR1/NGFI-A in the hippocampus, may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Role of glucocorticoid receptor (GR) in white adipose tissue beiging., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08624;Q8R463;Q8R5J0", "ec_number_list": [], "go_molecular_function": "GO:0004883 nuclear glucocorticoid receptor activity;GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0046685 response to arsenic-containing substance;GO:0048708 astrocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P06536-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01257-1", "uniprot_id": [ { "id": "CALC_RAT", "url": "https://www.uniprot.org/uniprot/P01257", "type": "external" } ], "mass": 15103.0, "length": 136, "protein_name": "Calcitonin", "gene_name": "Calca", "organism": "Rat", "refseq_name": "calcitonin gene-related peptide 1 isoform Calca preproprotein", "refseq_ac": [ { "id": "NP_059034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059034", "type": "external" } ], "gene_names_uniprotkb": "Calca; Calc", "gene_names_refseq": "CAL6; CGRP1; CGRP; Cal1; Calca; Calc; RATCAL6; calcitonin", "protein_names_uniprotkb": "Calcitonin", "protein_names_refseq": "CGRP-I; alpha-type CGRP; calcitonin gene-related peptide 1 isoform Calca preproprotein; calcitonin gene-related peptide 1; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; procalcitonin", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pyelonephritis (Disease Ontology:DOID:11400); osteoporosis (Disease Ontology:DOID:11476); prediabetes syndrome (Disease Ontology:DOID:11716); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); ischemia (Disease Ontology:DOID:326); middle cerebral artery infarction (Disease Ontology:DOID:3525); migraine (Disease Ontology:DOID:6364); stomach disease (Disease Ontology:DOID:76); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24241); (R-RNO-419812)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "1278175;22673903;2994212;38211380;38452411;3872459;38816868;39072399;6264603;6283379;6400492;6933496", "class_list": "", "function": "CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury. Publication Status: Online-Only, [RefSeq, PubMed]; CGRP promotes osteogenic differentiation by regulating macrophage M2 polarization through HDAC6/AKAP12 signaling pathway., [RefSeq, PubMed]; CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex., [UniProtKB, UniProtKB]; Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing., [RefSeq, PubMed]; Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (By similarity)., [UniProtKB, UniProtKB]; Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031716 calcitonin receptor binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure;GO:0031645 negative regulation of nervous system process;GO:0032730 positive regulation of interleukin-1 alpha production;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P01257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07652-1", "uniprot_id": [ { "id": "CAC1E_RAT", "url": "https://www.uniprot.org/uniprot/Q07652", "type": "external" } ], "mass": 252116.0, "length": 2222, "protein_name": "Voltage-dependent R-type calcium channel subunit alpha-1E", "gene_name": "Cacna1e", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1e; Cach6; Cacnl1a6", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent R-type calcium channel subunit alpha-1E; BII; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; RBE-II; RBE2; Voltage-gated calcium channel subunit alpha Cav2.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary ataxia (Disease Ontology:DOID:0050951); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); developmental and epileptic encephalopathy 69 (Disease Ontology:DOID:0112205); epilepsy (Disease Ontology:DOID:1826); migraine (Disease Ontology:DOID:6364)", "pathway": " (R-RNO-112308); (R-RNO-422356)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;38843836;8388125", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity;GO:0008332 low voltage-gated calcium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007626 locomotory behavior;GO:0008542 visual learning;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07652-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55156-1", "uniprot_id": [ { "id": "CLIP2_RAT", "url": "https://www.uniprot.org/uniprot/O55156", "type": "external" } ], "mass": 115480.0, "length": 1046, "protein_name": "CAP-Gly domain-containing linker protein 2", "gene_name": "Clip2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Clip2; Cyln2", "gene_names_refseq": "", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 2; CLIP-115; Cytoplasmic linker protein 115; Cytoplasmic linker protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:29264)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18683930;22673903;29393594;9427243", "class_list": "", "function": "Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0030425 dendrite;GO:0015630 microtubule cytoskeleton;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O55156-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54283-1", "uniprot_id": [ { "id": "CACB1_RAT", "url": "https://www.uniprot.org/uniprot/P54283", "type": "external" } ], "mass": 65680.0, "length": 597, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-1", "gene_name": "Cacnb1", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-1", "refseq_ac": [ { "id": "NP_059042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059042", "type": "external" } ], "gene_names_uniprotkb": "Cacnb1; Cacnlb1", "gene_names_refseq": "CAB1; Cacnb1", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-1; CAB1; Calcium channel voltage-dependent subunit beta 1", "protein_names_refseq": "brain calcium channel beta 1 subunit; calcium channel voltage-dependent subunit beta 1; calcium channel, voltage-dependent, beta 1 subunit; voltage-dependent L-type calcium channel subunit beta-1", "tax_id": 10116, "disease": "", "pathway": " (rno:50688); (R-RNO-112308); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1657644;21127204;22673903;24751537;38843836", "class_list": "", "function": "Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (Probable). Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005246 calcium channel regulator activity;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098794 postsynapse;GO:0016529 sarcoplasmic reticulum;GO:0030315 T-tubule;GO:0098793 presynapse", "go_biological_process": "GO:1904646 cellular response to amyloid-beta;GO:0006612 protein targeting to membrane;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P54283-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75UQ2-1", "uniprot_id": [ { "id": "CFDP1_RAT", "url": "https://www.uniprot.org/uniprot/Q75UQ2", "type": "external" } ], "mass": 32969.0, "length": 295, "protein_name": "Heterochromatin-stabilizing protein CFDP1", "gene_name": "Cfdp1", "organism": "Rat", "refseq_name": "heterochromatin-stabilizing protein CFDP1", "refseq_ac": [ { "id": "NP_955410", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955410", "type": "external" } ], "gene_names_uniprotkb": "Cfdp1; Bcnt", "gene_names_refseq": "Cfdp1", "protein_names_uniprotkb": "Heterochromatin-stabilizing protein CFDP1; Bucentaur; Craniofacial development protein 1", "protein_names_refseq": "bucentaur; chromatin stabilizing protein CFDP1; craniofacial development protein 1; heterochromatin-stabilizing protein CFDP1", "tax_id": 10116, "disease": "", "pathway": " (rno:292027)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;32432658", "class_list": "", "function": "Overcoming off-targets: assessing Western blot signals for Bcnt/Cfdp1, a tentative component of the chromatin remodeling complex., [RefSeq, PubMed]; Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000776 kinetochore;GO:0000812 Swr1 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007155 cell adhesion;GO:0042127 regulation of cell population proliferation;GO:0008360 regulation of cell shape;GO:2000270 negative regulation of fibroblast apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q75UQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54290-1", "uniprot_id": [ { "id": "CA2D1_RAT", "url": "https://www.uniprot.org/uniprot/P54290", "type": "external" } ], "mass": 123823.0, "length": 1091, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-1", "gene_name": "Cacna2d1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna2d1; Cacnl2a; Cchl2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 110 (Disease Ontology:DOID:0070395); brain infarction (Disease Ontology:DOID:3454)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1314383;22673903;24090084;38843836", "class_list": "", "function": "The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (By similarity). Plays an important role in excitation-contraction coupling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098992 neuronal dense core vesicle;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0086048 membrane depolarization during bundle of His cell action potential;GO:1904646 cellular response to amyloid-beta;GO:0006816 calcium ion transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051924 regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P54290-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08875-1", "uniprot_id": [ { "id": "DCLK1_RAT", "url": "https://www.uniprot.org/uniprot/O08875", "type": "external" } ], "mass": 47681.0, "length": 433, "protein_name": "Serine/threonine-protein kinase DCLK1", "gene_name": "Dclk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase DCLK1 isoform 1", "refseq_ac": [ { "id": "NP_445795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445795", "type": "external" } ], "gene_names_uniprotkb": "Dclk1; Cpg16; Dcamkl1", "gene_names_refseq": "Ania4; Cpg16; Dcamkl1; Dclk1", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK1; 2.7.11.1; Calcium/calmodulin-dependent protein kinase type I-like CPG16; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1", "protein_names_refseq": "double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin-like and CAM kinase-like 1; serine/threonine-protein kinase DCLK1 isoform 1; serine/threonine-protein kinase DCLK1", "tax_id": 10116, "disease": "dyslexia (Disease Ontology:DOID:4428)", "pathway": " (rno:83825)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18683930;22673903;26758546;27900578;30879761;33676985;35082322;38843836;9699150", "class_list": "", "function": "Candidate plasticity gene 16 and jun dimerization protein 2 are involved in the suppression of insulin gene expression in rat pancreatic INS-1 beta-cells., [RefSeq, PubMed]; Electrical stimulated-neurite outgrowth is regulated by MicroRNA-363-5p through targeting of DCLK1., [RefSeq, PubMed]; Intestinal microbiota profiles in a genetic model of colon tumorigenesis correlates with colon cancer biomarkers. Publication Status: Online-Only, [RefSeq, PubMed]; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The authors found that microtubule-binding protein doublecortin-like kinase 1 (DCLK1) labels a subset of dendritic microtubules and is required for KIF1-dependent dense-core vesicles (DCVs) trafficking into dendrites and dendrite development., [RefSeq, PubMed]; These results suggest that CPG16 plays a role in the suppression of insulin gene expression in pancreatic beta-cells under glucotoxic conditions., [RefSeq, PubMed]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The typical protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the protein is independent of its protein kinase activity. This gene is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the full-length nature of the variant produced from the 5' promoter has not been determined. Current reference sequence data represents two alternatively spliced transcript variants produced from the 3' promoter and their protein products lack the doublecortin domain.[provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:1900181 negative regulation of protein localization to nucleus;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08875-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30337-1", "uniprot_id": [ { "id": "CHIN_RAT", "url": "https://www.uniprot.org/uniprot/P30337", "type": "external" } ], "mass": 38224.0, "length": 334, "protein_name": "N-chimaerin", "gene_name": "Chn1", "organism": "Rat", "refseq_name": "N-chimaerin isoform 2", "refseq_ac": [ { "id": "NP_114472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114472", "type": "external" } ], "gene_names_uniprotkb": "Chn1; Arhgap2; Chn3; Chn", "gene_names_refseq": "Chn1", "protein_names_uniprotkb": "N-chimaerin; A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2", "protein_names_refseq": "A-chimaerin; N-chimaerin isoform 2; N-chimaerin; N-chimerin; NC; alpha-chimerin; chimerin (chimaerin) 1; rho GTPase-activating protein 2", "tax_id": 10116, "disease": "Duane retraction syndrome 2 (Disease Ontology:DOID:0061028); Duane retraction syndrome (Disease Ontology:DOID:12557)", "pathway": " (rno:84030)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1445199;15240697;15483118;16641100;17911252;21056981;22369992", "class_list": "", "function": "GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance., [UniProtKB]; GTPase-activating protein for p21-rac., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology, [RefSeq, PubMed]; Serum levels decreased significantly as gestation progressed, [RefSeq, PubMed]; Signaling via diacylglycerol may regulate the abundance of alpha1-chimaerin under physiological conditions, [RefSeq, PubMed]; These results indicate that active alpha2-chimaerin Rac GAP, Cdk5/p35, and its substrate CRMP-2, are implicated in the dynamics of growth cone guidance initiated through Sema 3A signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q505J4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0046875 ephrin receptor binding;GO:0001565 phorbol ester receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0048013 ephrin receptor signaling pathway;GO:0008045 motor neuron axon guidance;GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30337-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZR10-1", "uniprot_id": [ { "id": "DCDC2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZR10", "type": "external" } ], "mass": 52033.0, "length": 475, "protein_name": "Doublecortin domain-containing protein 2", "gene_name": "Dcdc2", "organism": "Rat", "refseq_name": "doublecortin domain-containing protein 2", "refseq_ac": [ { "id": "NP_001099580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099580", "type": "external" } ], "gene_names_uniprotkb": "Dcdc2", "gene_names_refseq": "Dcdc2a; Dcdc2", "protein_names_uniprotkb": "Doublecortin domain-containing protein 2", "protein_names_refseq": "doublecortin domain containing 2; doublecortin domain-containing protein 2", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 66 (Disease Ontology:DOID:0110517); nephronophthisis 19 (Disease Ontology:DOID:0111126); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); sclerosing cholangitis (Disease Ontology:DOID:14268); dyslexia (Disease Ontology:DOID:4428)", "pathway": " (rno:291130)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16278297;18313856;22673903;25601850", "class_list": "", "function": "Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (PubMed:16278297). Involved in the control of ciliogenesis and ciliary length (By similarity)., [UniProtKB, PubMed, UniProtKB]; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length., [UniProtKB, UniProtKB]; These results support the claim that knockdown of Dcdc2 expression results in neuronal migration disorders similar to those seen in the brains of dyslexics., [RefSeq, PubMed]; This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Knockdown of this gene expression results in neuronal migration disorders similar to those seen in the brains of dyslexics. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0005930 axoneme", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0060271 cilium assembly;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZR10-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11442-1", "uniprot_id": [ { "id": "CLH1_RAT", "url": "https://www.uniprot.org/uniprot/P11442", "type": "external" } ], "mass": 191599.0, "length": 1675, "protein_name": "Clathrin heavy chain 1", "gene_name": "Cltc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cltc", "gene_names_refseq": "", "protein_names_uniprotkb": "Clathrin heavy chain 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 56 (Disease Ontology:DOID:0080226); cold-induced sweating syndrome 1 (Disease Ontology:DOID:0080329)", "pathway": " (rno:54241); (R-RNO-177504); (R-RNO-190873); (R-RNO-196025); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038); (R-RNO-9013420); (R-RNO-9013424)", "pathway_count": 16, "publication_count": 8, "publication_id_list": "10655490;15858577;16968737;22673903;34502162;3480512;38843836;9827808", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). Plays a role in early autophagosome formation (By similarity). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0031072 heat shock protein binding;GO:0005198 structural molecule activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030118 clathrin coat;GO:0098835 presynaptic endocytic zone membrane;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005768 endosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006886 intracellular protein transport;GO:0031623 receptor internalization;GO:0090307 mitotic spindle assembly;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11442-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHW5-1", "uniprot_id": [ { "id": "CCG8_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHW5", "type": "external" } ], "mass": 43269.0, "length": 421, "protein_name": "Voltage-dependent calcium channel gamma-8 subunit", "gene_name": "Cacng8", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-8 subunit", "refseq_ac": [ { "id": "NP_542427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542427", "type": "external" } ], "gene_names_uniprotkb": "Cacng8", "gene_names_refseq": "Cacng8", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-8 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; TARP gamma-8; Transmembrane AMPAR regulatory protein gamma-8", "protein_names_refseq": "TARP gamma-8; calcium channel, voltage-dependent, gamma subunit 8; neuronal voltage-gated calcium channel gamma-8 subunit; transmembrane AMPAR regulatory protein gamma-8; voltage-dependent calcium channel gamma-8 subunit", "tax_id": 10116, "disease": "antisocial personality disorder (Disease Ontology:DOID:10939); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:140729); (R-RNO-399719); (R-RNO-5576892); (R-RNO-5576893); (R-RNO-5682910)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11738816;17880894;19234459;19265014;22673903;23687301;26725511;30872532;35136046;38843836", "class_list": "", "function": "AMPA-induced currents were recorded in the neurons using a whole-cell recording method. RESULTS: Four-hour exposure to AMPA significantly decreased the protein levels of TARP gamma-8 and GluA1 in the neurons at 17-18 DIV, but did not change the protein level of TARP gamma-8 in the neurons cultured at 7-8 DIV., [RefSeq, PubMed]; Mechanisms underlying TARP modulation of the GluA1/2-gamma8 AMPA receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state., [UniProtKB, PubMed, UniProtKB, PubMed]; Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits., [UniProtKB, UniProtKB]; This study presents a cryo-electron microscopy structure of the heteromeric GluA1/2 receptor associated with two transmembrane AMPAR regulatory protein (TARP) gamma8 auxiliary subunits, the principal AMPAR complex at hippocampal synapses., [RefSeq, PubMed]; Voltage-dependent calcium channels couple membrane depolarization in a number of cellular processes. These activities are regulated by distinct channels composed of the pore-forming alpha-1 subunit and the modulatory beta, alpha-2/delta and gamma subunits. The protein encoded by this gene represents one of the gamma subunits. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is located in a cluster with two similar gamma subunit-encoding genes on chromosome 1. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0030346 protein phosphatase 2B binding;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0032281 AMPA glutamate receptor complex;GO:0032590 dendrite membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse;GO:2000311 regulation of AMPA receptor activity;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VHW5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02485-1", "uniprot_id": [ { "id": "CAC1S_RAT", "url": "https://www.uniprot.org/uniprot/Q02485", "type": "external" } ], "mass": 210396.0, "length": 1850, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1S", "gene_name": "Cacna1s", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1S", "refseq_ac": [ { "id": "NP_446325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446325", "type": "external" } ], "gene_names_uniprotkb": "Cacna1s; Cach1; Cacn1; Cacnl1a3; Cchl1a3", "gene_names_refseq": "Cacna1s; Cchl1a3; RGD1565743", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1S; Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; ROB1; Voltage-gated calcium channel subunit alpha Cav1.1", "protein_names_refseq": "ROB1; calcium channel, voltage-dependent, L type, alpha 1S subunit; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1", "tax_id": 10116, "disease": "Timothy syndrome (Disease Ontology:DOID:0060173); congenital myopathy 18 (Disease Ontology:DOID:0081350); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); malignant hyperthermia (Disease Ontology:DOID:8545)", "pathway": " (rno:682930)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1279681;1335956;20101487;2174428;22673903;23943510;28044347;7479909", "class_list": "", "function": "Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Septic diaphragm contractility and expression of Cacna1s and RyR1 are significantly decreased in a sepsis model compared with controls., [RefSeq, PubMed]; The expression levels of dihydropyridine alpha1s and RyR1 receptors (the isoforms of skeletal muscles) are significantly lower in septic rats than in control rats., [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B3XZL8;P70484;Q01553;Q62817", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0036094 small molecule binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031674 I band;GO:0042383 sarcolemma;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006936 muscle contraction;GO:0007528 neuromuscular junction development;GO:0006816 calcium ion transport;GO:0001501 skeletal system development;GO:0048741 skeletal muscle fiber development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02485-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13233-1", "uniprot_id": [ { "id": "CN37_RAT", "url": "https://www.uniprot.org/uniprot/P13233", "type": "external" } ], "mass": 47268.0, "length": 420, "protein_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "gene_name": "Cnp", "organism": "Rat", "refseq_name": "2',3'-cyclic-nucleotide 3'-phosphodiesterase", "refseq_ac": [ { "id": "NP_036941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036941", "type": "external" } ], "gene_names_uniprotkb": "Cnp; Cnp1", "gene_names_refseq": "CNPF; CNPII; CNPI; Cnp1; Cnp", "protein_names_uniprotkb": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; 3.1.4.37; CNPase; CNP", "protein_names_refseq": "2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypomyelinating leukodystrophy 20 (Disease Ontology:DOID:0112153); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:25275)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11842207;12947117;22673903;22928743;30405014;3040924;31885393;34330062;7884818;7932861", "class_list": "", "function": "All pups with exposure to methadone demonstrated decreased expression of CNP in the cerebral cortex and hippocampus.In the cerebellum, PLP expression was downregulated without apparent alteration of CNP and MBP expression. PLP and MBP expression, but not CNP expression, were significantly inhibited in the brainstem., [RefSeq, PubMed]; CNP is a membrane-bound microtubule-associated protein that can link tubulin to membranes and may regulate cytoplasmic microtubule distribution, [RefSeq, PubMed]; Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility., [RefSeq, PubMed]; The role of CNPase, serine/threonine kinases, and MEL in the mPTP opening was examined. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V796;Q64575", "ec_number_list": [ { "id": "3.1.4.37", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.37", "type": "external" } ], "go_molecular_function": "GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0030551 cyclic nucleotide binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009214 cyclic nucleotide catabolic process;GO:0007409 axonogenesis;GO:0008344 adult locomotory behavior;GO:0030900 forebrain development;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13233-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21272-1", "uniprot_id": [ { "id": "CEBPB_RAT", "url": "https://www.uniprot.org/uniprot/P21272", "type": "external" } ], "mass": 31503.0, "length": 297, "protein_name": "CCAAT/enhancer-binding protein beta", "gene_name": "Cebpb", "organism": "Rat", "refseq_name": "CCAAT/enhancer-binding protein beta isoform LAP2", "refseq_ac": [ { "id": "NP_001288644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288644", "type": "external" } ], "gene_names_uniprotkb": "Cebpb; Crp2; Nf-il6; Sfb", "gene_names_refseq": "Cebpb; Il6dbp; NF-IL6; TCF5", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein beta; C/EBP beta; C/EBP-related protein 2; IL-6DBP; Interleukin-6-dependent-binding protein; LAP; LIP; Liver-enriched inhibitory protein; Liver-enriched transcriptional activator; SF-B; Silencer factor B", "protein_names_refseq": "C/EBP beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta isoform LAP2; IL-6DBP; SF-B; interleukin-6-dependent-binding protein; nuclear factor-IL6; silencer factor B", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); osteochondrodysplasia (Disease Ontology:DOID:2256); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (rno:24253); (R-RNO-2559582)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10635333;1377818;15308669;15785238;16246908;1884998;1934061;2171780;2253878;22673903;23312093;24438488;29393594;37541559;38114435;8336793", "class_list": "", "function": "Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:1934061). Promotes osteoblast differentiation and osteoclastogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Data demonstrate, that in neurons, C/EBP beta isoforms are differently modulated in apoptosis, [RefSeq, PubMed]; Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing., [UniProtKB, UniProtKB]; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8336793). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:10635333). The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA (By similarity). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:10635333). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (By similarity). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (PubMed:15308669)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease., [RefSeq, PubMed]; P53 regulates CCAAT/Enhancer binding protein beta gene expression., [RefSeq, PubMed]; This factor plays important roles in the regulation of thyroid specific genes., [RefSeq, PubMed]; This intronless gene encodes a member of the transcription factor family whose members contain a basic leucine-zipper domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. The encoded protein plays important roles in several cellular processes and in various diseases, including regulating cell proliferation, differentiation, apoptosis and neuroinflammation, and being involved in brain injury and inflammatory progression. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with different cellular localizations and distinct biological functions. [provided by RefSeq, Sep 2014]., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A2VD03", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0002432 granuloma formation;GO:0035711 T-helper 1 cell activation;GO:0072574 hepatocyte proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P21272-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41350-1", "uniprot_id": [ { "id": "CAV1_RAT", "url": "https://www.uniprot.org/uniprot/P41350", "type": "external" } ], "mass": 20553.0, "length": 178, "protein_name": "Caveolin-1", "gene_name": "Cav1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cav1; Cav", "gene_names_refseq": "", "protein_names_uniprotkb": "Caveolin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); mitochondrial complex IV deficiency nuclear type 7 (Disease Ontology:DOID:0070494); alcohol-associated liver disease (Disease Ontology:DOID:0070658); congenital generalized lipodystrophy type 3 (Disease Ontology:DOID:0111137); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); acoustic neuroma (Disease Ontology:DOID:12689); leiomyoma (Disease Ontology:DOID:127); primary pulmonary hypertension (Disease Ontology:DOID:14557); hypothyroidism (Disease Ontology:DOID:1459); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); transitional cell carcinoma (Disease Ontology:DOID:2671); high grade glioma (Disease Ontology:DOID:3070); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); psoriasis (Disease Ontology:DOID:8893); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25404); (R-RNO-203615); (R-RNO-203641); (R-RNO-209968); (R-RNO-210991); (R-RNO-4641262); (R-RNO-5218920); (R-RNO-8980692); (R-RNO-9009391); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 22, "publication_count": 4, "publication_id_list": "11883949;16358225;22673903;34502162", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)-hydroxycholesterol (20(S)-OHC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VIK8;Q8VIK9", "ec_number_list": [], "go_molecular_function": "GO:0070320 inward rectifier potassium channel inhibitor activity;GO:0060090 molecular adaptor activity;GO:0008142 oxysterol binding;GO:0005102 signaling receptor binding;GO:0016504 peptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0003057 regulation of the force of heart contraction by chemical signal;GO:0032507 maintenance of protein location in cell;GO:0044860 protein localization to plasma membrane raft;GO:0048550 negative regulation of pinocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P41350-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62628-1", "uniprot_id": [ { "id": "DLRB1_RAT", "url": "https://www.uniprot.org/uniprot/P62628", "type": "external" } ], "mass": 10990.0, "length": 96, "protein_name": "Dynein light chain roadblock-type 1", "gene_name": "Dynlrb1", "organism": "Rat", "refseq_name": "dynein light chain roadblock-type 1", "refseq_ac": [ { "id": "NP_571985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571985", "type": "external" } ], "gene_names_uniprotkb": "Dynlrb1; Dncl2a; Dnlc2a", "gene_names_refseq": "Dncl2a; Dynlrb1; km23", "protein_names_uniprotkb": "Dynein light chain roadblock-type 1; BLP; Bithoraxoid-like protein; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; robl/LC7-like protein", "protein_names_refseq": "BLP; bithoraxoid-like protein; dynein light chain 2A, cytoplasmic; dynein light chain roadblock-type 1; dynein, cytoplasmic, light chain 2A; dynein-associated protein Km23; dynein-associated protein RKM23; robl/LC7-like protein", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:170714); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10816553;26272270", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (By similarity). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88567;Q9D812", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:1904115 axon cytoplasm;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0007018 microtubule-based movement;GO:0009416 response to light stimulus;GO:0007632 visual behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62628-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63329-1", "uniprot_id": [ { "id": "PP2BA_RAT", "url": "https://www.uniprot.org/uniprot/P63329", "type": "external" } ], "mass": 58644.0, "length": 521, "protein_name": "Protein phosphatase 3 catalytic subunit alpha", "gene_name": "Ppp3ca", "organism": "Rat", "refseq_name": "protein phosphatase 3 catalytic subunit alpha", "refseq_ac": [ { "id": "NP_058737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058737", "type": "external" } ], "gene_names_uniprotkb": "Ppp3ca; Calna", "gene_names_refseq": "Calna1; Ppp3ca", "protein_names_uniprotkb": "Protein phosphatase 3 catalytic subunit alpha; 3.1.3.16; CAM-PRP catalytic subunit; CNA alpha; Calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform", "protein_names_refseq": "CAM-PRP catalytic subunit; CNA alpha; Calcineurin subunit A alpha; calcineurin A alpha; protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:24674); (R-RNO-2025928); (R-RNO-2871809); (R-RNO-4086398); (R-RNO-5607763)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10593895;11114196;1322410;1335233;18683930;18815128;2174876;22673903;23699505;24018048;2551293;31486013;31584202;34064311;37926341", "class_list": "", "function": "Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy under chronic intermittent hypoxia by downregulating the AMPK pathway., [RefSeq, PubMed]; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:1322410, PubMed:24018048). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (By similarity). Positively regulates the CACNA1B/CAV2.2-mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (PubMed:23699505). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (By similarity). Dephosphorylates and inactivates transcription factor ELK1 (By similarity). Dephosphorylates DARPP32 (By similarity). May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins (By similarity). Required for postnatal development of the nephrogenic zone and superficial glomeruli in the kidneys, cell cycle homeostasis in the nephrogenic zone, and ultimately normal kidney function (By similarity). Plays a role in intracellular AQP2 processing and localization to the apical membrane in the kidney, may thereby be required for efficient kidney filtration (By similarity). Required for secretion of salivary enzymes amylase, peroxidase, lysozyme and sialic acid via formation of secretory vesicles in the submandibular glands (By similarity). Required for calcineurin activity and homosynaptic depotentiation in the hippocampus (By similarity). Required for normal differentiation and survival of keratinocytes and therefore required for epidermis superstructure formation (By similarity). Positively regulates osteoblastic bone formation, via promotion of osteoblast differentiation (By similarity). Positively regulates osteoclast differentiation, potentially via NFATC1 signaling (By similarity). May play a role in skeletal muscle fiber type specification, potentially via NFATC1 signaling (By similarity). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). Required for antigen-specific T-cell proliferation response (By similarity). Dephosphorylates KLHL3, promoting the interaction between KLHL3 and WNK4 and subsequent degradation of WNK4 (By similarity). Negatively regulates SLC9A1 activity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Our results show that CaN/NFATc4 pathway were involved in the development of PTSD model, which suggested that the changes of CaN/NFATc4 pathway may be one of the pathological molecular mechanism in the dysfunction of hippocampus in PTSD., [RefSeq, PubMed]; Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase. Publication Status: Online-Only, [RefSeq, PubMed]; The combined inhibition of the CaMKIIdelta and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12816;P20652;Q6LDJ8;Q9WUV7;Q9Z1I5", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0016311 dephosphorylation;GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress;GO:1905205 positive regulation of connective tissue replacement;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63329-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R1-1", "uniprot_id": [ { "id": "CENPT_RAT", "url": "https://www.uniprot.org/uniprot/Q561R1", "type": "external" } ], "mass": 56861.0, "length": 518, "protein_name": "Centromere protein T", "gene_name": "Cenpt", "organism": "Rat", "refseq_name": "centromere protein T", "refseq_ac": [ { "id": "NP_001019428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019428", "type": "external" } ], "gene_names_uniprotkb": "Cenpt", "gene_names_refseq": "Cenpt; RGD1309383", "protein_names_uniprotkb": "Centromere protein T; CENP-T", "protein_names_refseq": "CENP-T; centromere protein T", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569)", "pathway": " (rno:307805); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q561R1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVI4-1", "uniprot_id": [ { "id": "CEND_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVI4", "type": "external" } ], "mass": 15043.0, "length": 149, "protein_name": "Cell cycle exit and neuronal differentiation protein 1", "gene_name": "Cend1", "organism": "Rat", "refseq_name": "cell cycle exit and neuronal differentiation protein 1", "refseq_ac": [ { "id": "NP_001014185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014185", "type": "external" } ], "gene_names_uniprotkb": "Cend1", "gene_names_refseq": "C38; Cend1; RGD1309401", "protein_names_uniprotkb": "Cell cycle exit and neuronal differentiation protein 1", "protein_names_refseq": "cell cycle exit and neuronal differentiation protein 1-like; cell cycle exit and neuronal differentiation protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361675)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10.1039/D0MO00044B;20002527;22673903;34106099", "class_list": "", "function": "C38 is a rat BM88 that is expressed in RGCs and horizontal cells in the adult rat retina. During development, C38 expression was up-regulated in parallel with neuronal maturation., [RefSeq, PubMed]; Involved in neuronal differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0021686 cerebellar granular layer maturation;GO:0021933 radial glia guided migration of cerebellar granule cell;GO:0021941 negative regulation of cerebellar granule cell precursor proliferation;GO:0007628 adult walking behavior;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5FVI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63400-1", "uniprot_id": [ { "id": "CLD3_RAT", "url": "https://www.uniprot.org/uniprot/Q63400", "type": "external" } ], "mass": 23315.0, "length": 219, "protein_name": "Claudin-3", "gene_name": "Cldn3", "organism": "Rat", "refseq_name": "claudin-3", "refseq_ac": [ { "id": "NP_113888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113888", "type": "external" } ], "gene_names_uniprotkb": "Cldn3", "gene_names_refseq": "Cldn3", "protein_names_uniprotkb": "Claudin-3; RVP1; Rat ventral prostate.1 protein", "protein_names_refseq": "RVP1; claudin-3; ventral prostate.1 protein", "tax_id": 10116, "disease": "peptic esophagitis (Disease Ontology:DOID:13976)", "pathway": " (rno:65130)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1723140;22673903;25649016;27038183", "class_list": "", "function": "Colonic glands without a fecal stream showed a reduction in claudin-3 content independent of the time and reduction in occludin content after 12 weeks of intestinal exclusion., [RefSeq, PubMed]; Identified four claudin isoforms (1, 3, 5, and 12) and showed that their expression levels were regulated as a group by copper, [RefSeq, PubMed]; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005198 structural molecule activity;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0090559 regulation of membrane permeability;GO:0007155 cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63400-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H34-1", "uniprot_id": [ { "id": "CFA97_RAT", "url": "https://www.uniprot.org/uniprot/Q66H34", "type": "external" } ], "mass": 61743.0, "length": 548, "protein_name": "Cilia- and flagella-associated protein 97", "gene_name": "Cfap97", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 97 isoform 2", "refseq_ac": [ { "id": "NP_001014023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014023", "type": "external" } ], "gene_names_uniprotkb": "Cfap97", "gene_names_refseq": "Cfap97; RGD1307325", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 97", "protein_names_refseq": "cilia- and flagella-associated protein 97 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:306469)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG3-1", "uniprot_id": [ { "id": "CNDP1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG3", "type": "external" } ], "mass": 54928.0, "length": 492, "protein_name": "Beta-Ala-His dipeptidase", "gene_name": "Cndp1", "organism": "Rat", "refseq_name": "beta-Ala-His dipeptidase", "refseq_ac": [ { "id": "NP_001007688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007688", "type": "external" } ], "gene_names_uniprotkb": "Cndp1; Cn1", "gene_names_refseq": "Cndp1", "protein_names_uniprotkb": "Beta-Ala-His dipeptidase; 3.4.13.20; CNDP dipeptidase 1; Carnosine dipeptidase 1", "protein_names_refseq": "CNDP dipeptidase 1; beta-Ala-His dipeptidase; carnosine dipeptidase 1 (metallopeptidase M20 family)", "tax_id": 10116, "disease": "glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (rno:307212)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12473676;16641100", "class_list": "", "function": "Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.20", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity;GO:0004180 carboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0051246 regulation of protein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HG3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FU5-1", "uniprot_id": [ { "id": "CI085_RAT", "url": "https://www.uniprot.org/uniprot/Q68FU5", "type": "external" } ], "mass": 17878.0, "length": 155, "protein_name": "Uncharacterized protein C9orf85 homolog", "gene_name": "C1h9orf85", "organism": "Rat", "refseq_name": "uncharacterized protein C9orf85 homolog", "refseq_ac": [ { "id": "NP_001007738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007738", "type": "external" } ], "gene_names_uniprotkb": "C1h9orf85", "gene_names_refseq": "C1h9orf85; RGD1359158", "protein_names_uniprotkb": "Uncharacterized protein C9orf85 homolog", "protein_names_refseq": "uncharacterized protein C9orf85 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361740)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG51-1", "uniprot_id": [ { "id": "CF047_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG51", "type": "external" } ], "mass": 31825.0, "length": 293, "protein_name": "Uncharacterized protein C6orf47 homolog", "gene_name": "G4", "organism": "Rat", "refseq_name": "uncharacterized protein C6orf47 homolog", "refseq_ac": [ { "id": "NP_001003975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003975", "type": "external" } ], "gene_names_uniprotkb": "G4", "gene_names_refseq": "G4", "protein_names_uniprotkb": "Uncharacterized protein C6orf47 homolog", "protein_names_refseq": "uncharacterized protein C6orf47 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:406868)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1L1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q0N1-1", "uniprot_id": [ { "id": "CNDP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q0N1", "type": "external" } ], "mass": 52693.0, "length": 475, "protein_name": "Cytosolic non-specific dipeptidase", "gene_name": "Cndp2", "organism": "Rat", "refseq_name": "cytosolic non-specific dipeptidase", "refseq_ac": [ { "id": "NP_001010920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010920", "type": "external" } ], "gene_names_uniprotkb": "Cndp2", "gene_names_refseq": "Cndp2", "protein_names_uniprotkb": "Cytosolic non-specific dipeptidase; 3.4.-.-; 3.4.13.18; CNDP dipeptidase 2; N-lactoyl-amino acid synthase/hydrolase; Threonyl dipeptidase", "protein_names_refseq": "CNDP dipeptidase 2 (metallopeptidase M20 family); cytosolic non-specific dipeptidase; cytosolic nonspecific dipeptidase 2; threonyl dipeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:291394); (R-RNO-174403); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15326124;18790006;22673903;29393594;34502162", "class_list": "", "function": "Cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and pseudopeptides. Substrates include L-cysteinylglycine, an intermediate metabolite of the gamma-glutamyl cycle of glutathione metabolism (By similarity). Can also hydrolyze threonyl-containing dipeptides (By similarity). Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N-[(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which it can also hydrolyze in vitro. N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance. Carnosine is probably not a physiological substrate and L-homocarnosine is not a substrate for this enzyme. Plays a role in the regulation of cell cycle arrest and apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0070573 metallodipeptidase activity;GO:0008233 peptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0019184 nonribosomal peptide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6Q0N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810D1-1", "uniprot_id": [ { "id": "CHP2_RAT", "url": "https://www.uniprot.org/uniprot/Q810D1", "type": "external" } ], "mass": 22486.0, "length": 196, "protein_name": "Calcineurin B homologous protein 2", "gene_name": "Chp2", "organism": "Rat", "refseq_name": "calcineurin B homologous protein 2", "refseq_ac": [ { "id": "NP_877402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877402", "type": "external" } ], "gene_names_uniprotkb": "Chp2", "gene_names_refseq": "Chp2; chp-2", "protein_names_uniprotkb": "Calcineurin B homologous protein 2; Chp-2", "protein_names_refseq": "calcineurin B homologous protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:308965)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12576672;20713027;22673903", "class_list": "", "function": "CHP2 is predominantly expressed in epithelial cells of the small and large intestine where it may regulate epithelial Na+/H+ exchanger(NHE)isoforms NHE2-4., [RefSeq, PubMed]; Calcineurin B isoforms showed increased expression throughout the CA1 and CA2 while there was a decrease in expression within the ipsilateral dentate gyrus., [RefSeq, PubMed]; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0008284 positive regulation of cell population proliferation;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q810D1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Y8-1", "uniprot_id": [ { "id": "CAC1I_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0Y8", "type": "external" } ], "mass": 243693.0, "length": 2201, "protein_name": "Voltage-dependent T-type calcium channel subunit alpha-1I", "gene_name": "Cacna1i", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1i", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent T-type calcium channel subunit alpha-1I; CaVT.3; Voltage-gated calcium channel subunit alpha Cav3.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:56827)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10066244;11073957;22673903", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the `low-voltage activated (LVA)` group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9EQ59", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0008332 low voltage-gated calcium channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0043005 neuron projection;GO:0005891 voltage-gated calcium channel complex;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0006816 calcium ion transport;GO:0086010 membrane depolarization during action potential;GO:0030431 sleep", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z0Y8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00961-1", "uniprot_id": [ { "id": "NMDE3_RAT", "url": "https://www.uniprot.org/uniprot/Q00961", "type": "external" } ], "mass": 135271.0, "length": 1237, "protein_name": "Glutamate receptor ionotropic, NMDA 2C", "gene_name": "Grin2c", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 2C precursor", "refseq_ac": [ { "id": "NP_001426378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426378", "type": "external" } ], "gene_names_uniprotkb": "Grin2c", "gene_names_refseq": "GluN2C; Grin2c; NMDAR2C; NR2C", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2C; NMDA glutamate receptor; glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor ionotropic, NMDA 2C precursor; glutamate receptor ionotropic, NMDA 2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; glutamate receptor, ionotropic, NMDA2C", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:24411); (R-RNO-438066); (R-RNO-8849932); (R-RNO-9609736)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "1350383;22673903;27845401;28095420;28126851;31969570;36959261;7569905;8428958;9463421;9647694", "class_list": "", "function": "A neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1350383, PubMed:8428958). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1350383, PubMed:28095420, PubMed:28126851, PubMed:8428958). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:1350383, PubMed:8428958, PubMed:9463421)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]; UBP791 ((2S*, 3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2, 3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity over GluN2A-containing receptors, and that a methionine and a lysine residue in the ligand binding pocket are the critical molecular elements for the subtype-specific binding. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005261 monoatomic cation channel activity;GO:0004970 glutamate-gated receptor activity;GO:0016595 glutamate binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903539 protein localization to postsynaptic membrane;GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0042391 regulation of membrane potential;GO:0050885 neuromuscular process controlling balance;GO:0060079 excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q00961-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00564-1", "uniprot_id": [ { "id": "KCRM_RAT", "url": "https://www.uniprot.org/uniprot/P00564", "type": "external" } ], "mass": 43045.0, "length": 381, "protein_name": "Creatine kinase M-type", "gene_name": "Ckm", "organism": "Rat", "refseq_name": "creatine kinase M-type", "refseq_ac": [ { "id": "NP_036662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036662", "type": "external" } ], "gene_names_uniprotkb": "Ckm; Ckmm", "gene_names_refseq": "CPK-M; Ckmm; Ckm", "protein_names_uniprotkb": "Creatine kinase M-type; 2.7.3.2; CPK-M; Creatine kinase M chain; Creatine phosphokinase M-type; M-CK", "protein_names_refseq": "M-CK; creatine kinase M chain; creatine kinase M-type; creatine kinase, muscle; creatine phosphokinase M-type", "tax_id": 10116, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); colitis (Disease Ontology:DOID:0060180); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); ischemia (Disease Ontology:DOID:326); functional colonic disease (Disease Ontology:DOID:3877); rhinitis (Disease Ontology:DOID:4483); muscular atrophy (Disease Ontology:DOID:767); irritable bowel syndrome (Disease Ontology:DOID:9778)", "pathway": " (rno:24265); (R-RNO-71288)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "14985449;16916915;17153612;21768101;22673903;26116865;34502162;6209281", "class_list": "", "function": "Creatine kinase inhibition also mimics a definitive characteristic of heart failure, the inability to respond to increased demand. Novel therapies for pulmonary artery hypertension are needed., [RefSeq, PubMed]; Data show that taurine minimizes lactic acidosis and preserves creatine kinase activity and myocardial contractility after ischemia/reperfusion., [RefSeq, PubMed]; Endotoxin-induced sepsis markedly reduced diaphragm and cardiac mitochondrial creatine kinase activity, [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6R9", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P00564-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10728-1", "uniprot_id": [ { "id": "MYPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q10728", "type": "external" } ], "mass": 115283.0, "length": 1032, "protein_name": "Protein phosphatase 1 regulatory subunit 12A", "gene_name": "Ppp1r12a", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 12A", "refseq_ac": [ { "id": "NP_446342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446342", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r12a; Mbs; Mypt1", "gene_names_refseq": "M110; MBSP; Mypt1; Ppp1r12a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 12A; MBSP; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; PP-1M; Protein phosphatase myosin-binding subunit; Protein phosphatase subunit 1M; Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110", "protein_names_refseq": "PP-1M; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase myosin-binding subunit; protein phosphatase subunit 1M; serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110; smooth muscle myosin phosphatase myosin-binding subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:116670); (R-RNO-2565942); (R-RNO-5625740); (R-RNO-5627123)", "pathway_count": 4, "publication_count": 46, "publication_id_list": "10579722;10712248;11384979;15823093;16641100;17880363;18032393;18682436;18683930;19103285;19131646;19296091;19359365;20351047;20805095;21058010;21699756;21787615;21827498;22004427;22673903;22948155;23219599;23230233;23439928;24753814;25557225;25995821;26004531;26163515;26494230;26610064;26721393;26759702;26807025;26864694;28208012;29383848;29390250;29458039;29795210;30962047;38843836;7988720;8543033;8662509", "class_list": "", "function": "Both atorvastatin (10(-4) m) and Y-27632 (10(-6) m) pretreatment inhibited the phosphorylation of myosin phosphatase target subunit-1 (MYPT-1)., [RefSeq, PubMed]; EGF induces Ca(2+) sensitization in vascular smooth muscle by Rho-kinase-dependent inactivation of MLCP mediated by the EGF receptor/MEK/Erk1/2 pathway, [RefSeq, PubMed]; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nuclear translocation of CaMKIIdelta3 following dephosphorylation at Ser(332) by PP1 likely accounts for BDNF expression and subsequent neurite extension and survival of dopaminergic neurons., [RefSeq, PubMed]; Phos-tag SDS-PAGE thus provides a suitable and convenient method for analysis of the complex, multisite MYPT1 phosphorylation events involved in the regulation of myosin light chain phosphatase activity and smooth muscle contraction., [RefSeq, PubMed]; Reduction of blood pressure elevation by losartan in spontaneously hypertensive rats occurs through the suppression of LARG expression and MYPT-1 phosphorylation in vascular smooth muscle cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62937;Q9WU33", "ec_number_list": [], "go_molecular_function": "GO:0017020 myosin phosphatase regulator activity;GO:0004857 enzyme inhibitor activity;GO:0019901 protein kinase binding;GO:0071889 14-3-3 protein binding;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007165 signal transduction;GO:0030155 regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046822 regulation of nucleocytoplasmic transport", "synthesized_glycan_count": 0, "hit_score": 4.9, "record_id": "Q10728-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22829-1", "uniprot_id": [ { "id": "NR4A1_RAT", "url": "https://www.uniprot.org/uniprot/P22829", "type": "external" } ], "mass": 64282.0, "length": 597, "protein_name": "Nuclear receptor subfamily 4 group A member 1", "gene_name": "Nr4a1", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 4 group A member 1", "refseq_ac": [ { "id": "NP_077364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077364", "type": "external" } ], "gene_names_uniprotkb": "Nr4a1; Hmr; Ngfib", "gene_names_refseq": "HMR; Ngfi-b; Nr4a1; Nur77", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 1; NGFI-B; NUR77; Nerve growth factor-induced protein I-B; Orphan nuclear receptor HMR", "protein_names_refseq": "Orphan nuclear receptor HMR; immediate early gene transcription factor NGFI-B; nerve growth factor induced protein I-B; nuclear receptor subfamily 4 group A member 1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:79240); (R-RNO-198693); (R-RNO-383280)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10331876;11883936;1314418;15716272;3272167;36307672;37108481;38310251;38836656;8227042;8395013;8473329;9395454", "class_list": "", "function": "Chronic N-Acetyl-Cysteine Treatment Enhances the Expression of the Immediate Early Gene Nr4a1 in Response to an Acute Challenge in Male Rats: Comparison with the Antidepressant Venlafaxine. Publication Status: Online-Only, [RefSeq, PubMed]; HUMSCs Transplantation Regulates AMPK/NR4A1 Signaling Axis to Inhibit Ovarian Fibrosis in POI Rats., [RefSeq, PubMed]; Hyperinsulinemia impairs decidualization via AKT-NR4A1 signaling: new insight into polycystic ovary syndrome (PCOS)-related infertility. Publication Status: Online-Only, [RefSeq, PubMed]; In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nur77 induced by HIF-1alpha mediates vascular remodeling in hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:10331876). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (By similarity). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (PubMed:8473329). Plays a role in the vascular response to injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration. Plays a role in the vascular response to injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8M4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22829-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64605-1", "uniprot_id": [ { "id": "PTPRS_RAT", "url": "https://www.uniprot.org/uniprot/Q64605", "type": "external" } ], "mass": 211931.0, "length": 1907, "protein_name": "Receptor-type tyrosine-protein phosphatase S", "gene_name": "Ptprs", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase S isoform 1 precursor", "refseq_ac": [ { "id": "NP_001418666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418666", "type": "external" } ], "gene_names_uniprotkb": "Ptprs", "gene_names_refseq": "Larptp2; Ptprd; Ptprs; Ptpsigma.; Ptpsigma; R-PTP-S; R-PTP-sigma; Rptpd", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase S; 3.1.3.48; LAR-PTP2; Leukocyte common antigen-related protein-tyrosine phosphatase 2; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase sigma", "protein_names_refseq": "leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase, receptor type, D; receptor-type tyrosine-protein phosphatase S isoform 1 precursor; receptor-type tyrosine-protein phosphatase S; receptor-type tyrosine-protein phosphatase sigma", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:25529); (R-RNO-388844); (R-RNO-8849932)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17967490;18058037;22519304;26464223;28752900;33662380;38843836;8068021", "class_list": "", "function": "Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (By similarity). Functions as tyrosine phosphatase (PubMed:8068021). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRsigma., [RefSeq, PubMed]; Our study shows that modulation of PTPsigma is a potential therapeutic strategy for root avulsion. Publication Status: Online-Only, [RefSeq, PubMed]; The present study found that astrocytes aberrantly and progressively expressed PTPsigma and LAR at the site of motor neuron degeneration in Tg ALS model rats with mutant SOD1., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q07808;Q3KRE9;Q64621;Q64675", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0035374 chondroitin sulfate binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone;GO:0043204 perikaryon", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0099054 presynapse assembly;GO:0007165 signal transduction;GO:0021510 spinal cord development;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64605-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11167-1", "uniprot_id": [ { "id": "GTR1_RAT", "url": "https://www.uniprot.org/uniprot/P11167", "type": "external" } ], "mass": 53963.0, "length": 492, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 1", "gene_name": "Slc2a1", "organism": "Rat", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 1", "refseq_ac": [ { "id": "NP_620182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620182", "type": "external" } ], "gene_names_uniprotkb": "Slc2a1; Glut1", "gene_names_refseq": "GLUTB; GTG1; Glut1; Gtg3; RATGTG1; Slc2a1", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 1; GLUT-1; Glucose transporter type 1, erythrocyte/brain", "protein_names_refseq": "GLUT-1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; glucose transporter type 1, erythrocyte/brain; solute carrier family 2 (facilitated glucose transporter), member 1; solute carrier family 2, facilitated glucose transporter member 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); myelomeningocele (Disease Ontology:DOID:0060326); glucose transporter type 1 deficiency syndrome (Disease Ontology:DOID:0070560); glucose transporter type 1 deficiency syndrome 1 (Disease Ontology:DOID:0070561); dystonia 9 (Disease Ontology:DOID:0090044); glucose transporter type 1 deficiency syndrome 2 (Disease Ontology:DOID:0090045); Hirschsprung's disease (Disease Ontology:DOID:10487); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); childhood absence epilepsy (Disease Ontology:DOID:1825); nephroblastoma (Disease Ontology:DOID:2154); hemangioma (Disease Ontology:DOID:255); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24778); (R-RNO-189200); (R-RNO-196836); (R-RNO-422356); (R-RNO-5653890)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10198040;15708368;21076856;2211693;22673903;3016720;3198639;35713797;36291063;36521282;36963496;37879153", "class_list": "", "function": "A glucose-sensing mechanism with glucose transporter 1 and pyruvate kinase in the area postrema regulates hepatic glucose production in rats., [RefSeq, PubMed]; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:2211693). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation., [UniProtKB, UniProtKB]; Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats., [RefSeq, PubMed]; Increased GLUT1 expression and localization to Golgi apparatus of acinar cells in the parotid gland of Goto-Kakizaki diabetic rats., [RefSeq, PubMed]; Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0001666 response to hypoxia;GO:0021987 cerebral cortex development;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P11167-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54852-1", "uniprot_id": [ { "id": "KCNH7_RAT", "url": "https://www.uniprot.org/uniprot/O54852", "type": "external" } ], "mass": 134901.0, "length": 1195, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH7", "gene_name": "Kcnh7", "organism": "Rat", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH7", "refseq_ac": [ { "id": "NP_571987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571987", "type": "external" } ], "gene_names_uniprotkb": "Kcnh7; Erg3", "gene_names_refseq": "Kcnh7; erg3", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH7; ERG-3; Eag-related protein 3; Ether-a-go-go-related gene potassium channel 3; Ether-a-go-go-related protein 3; Potassium voltage-gated channel subfamily H member 7; Voltage-gated potassium channel subunit Kv11.3", "protein_names_refseq": "ERG-3; eag-related protein 3; ether-a-go-go-related gene potassium channel 3; ether-a-go-go-related protein 3; potassium channel erg3; potassium channel, voltage gated eag related subfamily H, member 7; potassium voltage-gated channel, subfamily H (eag-related), member 7; voltage-gated inwardly rectifying potassium channel KCNH7; voltage-gated potassium channel subunit Kv11.3", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:170739); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10718922;11212207;18162604;22673903;9390998", "class_list": "", "function": "Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9390998). Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification (PubMed:11212207, PubMed:9390998)., [UniProtKB, PubMed, PubMed]; The differential sensitivity of hERG1 and rERG3 channels to the agonist effect of RPR could be accounted for by a single S5 residue (Thr556 in hERG1, Ile558 in rERG3)., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity;GO:0020037 heme binding;GO:0005249 voltage-gated potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007623 circadian rhythm;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54852-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62483-1", "uniprot_id": [ { "id": "KCAB2_RAT", "url": "https://www.uniprot.org/uniprot/P62483", "type": "external" } ], "mass": 41021.0, "length": 367, "protein_name": "Voltage-gated potassium channel subunit beta-2", "gene_name": "Kcnab2", "organism": "Rat", "refseq_name": "voltage-gated potassium channel subunit beta-2 isoform 5", "refseq_ac": [ { "id": "NP_059000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059000", "type": "external" } ], "gene_names_uniprotkb": "Kcnab2; Ckbeta2; Kcnb3", "gene_names_refseq": "Kcnab2", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-2; 1.1.1.-; K(+) channel subunit beta-2; Kv-beta-2", "protein_names_refseq": "K(+) channel subunit beta-2; kv-beta-2; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2 isoform 5; voltage-gated potassium channel subunit beta-2", "tax_id": 10116, "disease": "chromosome 1p36 deletion syndrome (Disease Ontology:DOID:0060410)", "pathway": " (rno:29738); (R-RNO-1296072); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 26, "publication_id_list": "10399921;10477520;10884227;10896669;11086297;12860406;15618540;16002581;16079148;16770729;18003609;18004376;18672894;18806782;20360102;20534430;21209188;21357749;22673903;23318870;23705070;24211303;25066316;8183366;9334400;9763623", "class_list": "", "function": "Article reports a newly identified protein-protein interaction between the PSD-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2, [RefSeq, PubMed]; Data suggest that potassium channel Kvbeta2 inhibitors could serve as tools to decipher the role of Kvbeta2 in vivo and, eventually, inform the development of novel therapeutics., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10896669, PubMed:18003609, PubMed:21357749, PubMed:9763623). The beta-2/KCNAB2 subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:21357749). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (PubMed:18672894, PubMed:21209188). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (PubMed:18672894). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (PubMed:18672894). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97381;Q60942;Q64284", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0044877 protein-containing complex binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0050905 neuromuscular process;GO:0002244 hematopoietic progenitor cell differentiation;GO:0045445 myoblast differentiation;GO:2000008 regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P62483-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62667-1", "uniprot_id": [ { "id": "MVP_RAT", "url": "https://www.uniprot.org/uniprot/Q62667", "type": "external" } ], "mass": 95798.0, "length": 861, "protein_name": "Major vault protein", "gene_name": "Mvp", "organism": "Rat", "refseq_name": "major vault protein", "refseq_ac": [ { "id": "NP_073206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073206", "type": "external" } ], "gene_names_uniprotkb": "Mvp", "gene_names_refseq": "Mvp", "protein_names_uniprotkb": "Major vault protein; MVP", "protein_names_refseq": "major vault protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64681); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10551828;11727830;16441665;18044992;19150846;22673903;29093465;7828886", "class_list": "", "function": "Casein kinase II enhances the phosphorylation of MVP in PC12 cells.Our results suggest that cell-specific phosphorylation of MVP may play a critical role in vault function., [RefSeq, PubMed]; Data show that the interaction between Src and major vault protein (MVP) is critically dependent on Src activity and protein (MVP) tyrosyl phosphorylation, which are induced by epidermal growth factor stimulation. Erratum:[FEBS J. 2006 Jun;273(11):2577], [RefSeq, PubMed]; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases., [UniProtKB, UniProtKB]; Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (By similarity). Vaults may play a role in nucleo-cytoplasmic transport (By similarity). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (By similarity). Down-regulates SRC activity and signaling through MAP kinases (By similarity)., [UniProtKB, UniProtKB]; The predicted docking shows that the vault-interacting domain of vault poly(ADP-ribose)-polymerase (INT) interaction sites are located between MVP domains 3 and 5. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0072376 protein activation cascade;GO:0038127 ERBB signaling pathway;GO:0008283 cell population proliferation;GO:0035556 intracellular signal transduction;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62667-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACE5-1", "uniprot_id": [ { "id": "INTU_RAT", "url": "https://www.uniprot.org/uniprot/D4ACE5", "type": "external" } ], "mass": 105142.0, "length": 942, "protein_name": "Protein inturned", "gene_name": "Intu", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Intu; Pdzd6", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein inturned; Inturned planar cell polarity effector homolog; PDZ domain-containing protein 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); orofaciodigital syndrome XVII (Disease Ontology:DOID:0080289)", "pathway": " (R-RNO-5610787)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. Required for recruitment of CPLANE2 to the mother centriole. Binds phosphatidylinositol 3-phosphate with highest affinity, followed by phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0009986 cell surface;GO:0031514 motile cilium;GO:0005814 centriole", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0021513 spinal cord dorsal/ventral patterning;GO:0007399 nervous system development;GO:0030216 keratinocyte differentiation;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ACE5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08962-1", "uniprot_id": [ { "id": "KCNH2_RAT", "url": "https://www.uniprot.org/uniprot/O08962", "type": "external" } ], "mass": 126952.0, "length": 1163, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH2", "gene_name": "Kcnh2", "organism": "Rat", "refseq_name": "voltage-gated inwardly rectifying potassium channel KCNH2", "refseq_ac": [ { "id": "NP_446401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446401", "type": "external" } ], "gene_names_uniprotkb": "Kcnh2; Erg", "gene_names_refseq": "ERG1; Kcnh2", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH2; ERG-1; Eag-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go-related protein 1; Potassium voltage-gated channel subfamily H member 2; RERG; Voltage-gated potassium channel subunit Kv11.1; r-ERG", "protein_names_refseq": "ERG-1; RERG; eag-related protein 1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; voltage-gated inwardly rectifying potassium channel KCNH2; voltage-gated potassium channel subunit Kv11.1", "tax_id": 10116, "disease": "short QT syndrome (Disease Ontology:DOID:0050793); long QT syndrome 2 (Disease Ontology:DOID:0110645); heart conduction disease (Disease Ontology:DOID:10273); epilepsy (Disease Ontology:DOID:1826); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:117018); (R-RNO-1296072); (R-RNO-5576890)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10718922;11212207;14525949;22673903;32559772;33263944;33426760;35841324;38063256;9012748;9664620", "class_list": "", "function": "Comparative Study of the Effect of Macrolide Antibiotics Erythromycin, Clarithromycin, and Azithromycin on the ERG1 Gene Expression in H9c2 Cardiomyoblast Cells., [RefSeq, PubMed]; ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling., [RefSeq, PubMed]; ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis., [RefSeq, PubMed]; Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2-integrin beta1 complex., [RefSeq, PubMed]; Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction., [RefSeq, PubMed]; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:11212207, PubMed:9664620). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:11212207, PubMed:9664620). Channel properties are modulated by cAMP and subunit assembly. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O08720", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0005216 monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:1901380 negative regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903765 negative regulation of potassium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08962-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97756-1", "uniprot_id": [ { "id": "KKCC1_RAT", "url": "https://www.uniprot.org/uniprot/P97756", "type": "external" } ], "mass": 55908.0, "length": 505, "protein_name": "Calcium/calmodulin-dependent protein kinase kinase 1", "gene_name": "Camkk1", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase kinase 1", "refseq_ac": [ { "id": "NP_113850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113850", "type": "external" } ], "gene_names_uniprotkb": "Camkk1", "gene_names_refseq": "Camkk1", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase kinase 1; 2.7.11.17; CaM-KK 1; CaM-KK alpha; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaMKK 1; CaMKK alpha; Calcium/calmodulin-dependent protein kinase kinase alpha", "protein_names_refseq": "alpha CaMKK; caM-KK 1; caM-KK alpha; caM-kinase IV kinase; caM-kinase kinase 1; caM-kinase kinase alpha; caMKK 1; caMKK alpha; calcium/calmodulin-dependent protein kinase kinase 1, alpha; calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:60341); (R-RNO-111932); (R-RNO-442729); (R-RNO-9619229)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10187789;10336483;10467092;10651863;18710651;22673903;26050738;27151216;33197510;34875535;7642608;8631893;8827455;8929978;9195898;9335539;9859994", "class_list": "", "function": "CaMKII(alpha) expression levels in hippocampus of chronic epileptic rats may be related with their impaired spatial learning and memory., [RefSeq, PubMed]; CaMKKalpha and CaMKKbeta are capable of phosphorylating and activating CaMKIV in living cells., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death., [UniProtKB, PubMed, PubMed, PubMed]; Ghrelin inhibited pressure overload-induced cardiac hypertrophy by promoting autophagy via CaMKK/AMPK signaling pathway., [RefSeq, PubMed]; Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase., [RefSeq, PubMed]; Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64572;Q794E3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0045860 positive regulation of protein kinase activity;GO:0032147 activation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P97756-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83748-1", "uniprot_id": [ { "id": "PRS30_RAT", "url": "https://www.uniprot.org/uniprot/P83748", "type": "external" } ], "mass": 33086.0, "length": 304, "protein_name": "Serine protease 30", "gene_name": "Prss30", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prss30; Disp; Tmprss8; Tmsp-1; Tmsp1", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease 30; 3.4.21.-; Distal intestinal serine protease; TMSP-1; Transmembrane serine protease 1; Transmembrane serine protease 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287106)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14669991", "class_list": "", "function": "Selectively cleaves synthetic peptide substrates of trypsin. Activates the epithelial sodium channel ENaC., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83748-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6WRH9-1", "uniprot_id": [ { "id": "IGS10_RAT", "url": "https://www.uniprot.org/uniprot/Q6WRH9", "type": "external" } ], "mass": 284743.0, "length": 2597, "protein_name": "Immunoglobulin superfamily member 10", "gene_name": "Igsf10", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 10 precursor", "refseq_ac": [ { "id": "NP_942063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942063", "type": "external" } ], "gene_names_uniprotkb": "Igsf10; Cmf608", "gene_names_refseq": "Igsf10", "protein_names_uniprotkb": "Immunoglobulin superfamily member 10; CMF608; Calvaria mechanical force protein 608; IgSF10", "protein_names_refseq": "CMF608; bone specific CMF608; calvaria mechanical force protein 608; immunoglobulin superfamily member 10 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:310448)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14962803;16641100", "class_list": "", "function": "Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (PubMed:14962803)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 11, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0042246 tissue regeneration;GO:0001503 ossification;GO:2001222 regulation of neuron migration;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6WRH9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12839-1", "uniprot_id": [ { "id": "NFM_RAT", "url": "https://www.uniprot.org/uniprot/P12839", "type": "external" } ], "mass": 95791.0, "length": 846, "protein_name": "Neurofilament medium polypeptide", "gene_name": "Nefm", "organism": "Rat", "refseq_name": "neurofilament medium polypeptide", "refseq_ac": [ { "id": "NP_058725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058725", "type": "external" } ], "gene_names_uniprotkb": "Nefm; Nef3; Nfm", "gene_names_refseq": "Nef3; Nefm; Nfm", "protein_names_uniprotkb": "Neurofilament medium polypeptide; 160 kDa neurofilament protein; NF-M; Neurofilament 3; Neurofilament triplet M protein", "protein_names_refseq": "160 kDa neurofilament protein; NF-M; Neurofilament protein, middle polypeptide; neurofilament 3, medium; neurofilament medium polypeptide; neurofilament triplet M protein; neurofilament, medium polypeptide", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526)", "pathway": " (rno:24588)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1321159;1537832;16006557;22673903;2441012;8344946;8702840;9388258", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q63370", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005200 structural constituent of cytoskeleton;GO:0015643 toxic substance binding;GO:0044877 protein-containing complex binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0031594 neuromuscular junction;GO:0043204 perikaryon", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0008088 axo-dendritic transport;GO:0021510 spinal cord development;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12839-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQM5-1", "uniprot_id": [ { "id": "KPRP_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQM5", "type": "external" } ], "mass": 76358.0, "length": 699, "protein_name": "Keratinocyte proline-rich protein", "gene_name": "Kprp", "organism": "Rat", "refseq_name": "keratinocyte proline-rich protein", "refseq_ac": [ { "id": "NP_001002290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002290", "type": "external" } ], "gene_names_uniprotkb": "Kprp", "gene_names_refseq": "Kprp", "protein_names_uniprotkb": "Keratinocyte proline-rich protein", "protein_names_refseq": "keratinocyte proline-rich protein; keratinocytes proline-rich protein", "tax_id": 10116, "disease": "", "pathway": " (rno:432393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12668678", "class_list": "", "function": "Kprp (keratinocyte proline-rich protein) is expressed by fetal dermal keratinocytes during late gestation and is a new marker of maturing epidermis during fetal skin development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0061436 establishment of skin barrier;GO:0008544 epidermis development;GO:0043588 skin development;GO:0002934 desmosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TQM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00959-1", "uniprot_id": [ { "id": "NMDE1_RAT", "url": "https://www.uniprot.org/uniprot/Q00959", "type": "external" } ], "mass": 165469.0, "length": 1464, "protein_name": "Glutamate receptor ionotropic, NMDA 2A", "gene_name": "Grin2a", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 2A precursor", "refseq_ac": [ { "id": "NP_036705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036705", "type": "external" } ], "gene_names_uniprotkb": "Grin2a", "gene_names_refseq": "GluN2A; Grin2a; NMDAR2A; NR2A", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2A; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A precursor; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); Warsaw breakage syndrome (Disease Ontology:DOID:0060535); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); placental insufficiency (Disease Ontology:DOID:3891); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24409); (R-RNO-438066); (R-RNO-8849932); (R-RNO-9609736)", "pathway_count": 4, "publication_count": 40, "publication_id_list": "10.1039/D0MO00044B;11104776;11160393;11588171;11675505;11929923;12391275;1350383;14602821;16281028;16495444;22673903;22870316;22960932;23625947;24090084;24462099;24607230;24769228;26441533;26679993;27618671;27771532;27916457;28384476;28468946;28760974;30500536;34106099;36521778;36959261;38179739;38569938;38853550;7569905;8428958;9463421;9509416;9647694;9694864", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (Probable) (PubMed:11160393, PubMed:11929923, PubMed:1350383, PubMed:14602821, PubMed:30500536). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:16281028, PubMed:23625947, PubMed:24462099, PubMed:27618671, PubMed:27916457, PubMed:28468946, PubMed:30500536, Ref.2). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:11160393, PubMed:11929923, PubMed:14602821, PubMed:23625947, PubMed:24607230, PubMed:28384476, PubMed:28760974, PubMed:9463421, Ref.2). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization., [RefSeq, PubMed]; GluN2A- and GluN2B-containing pre-synaptic N-methyl-d-aspartate receptors differentially regulate action potential-evoked Ca[2+] influx via modulation of SK channels., [RefSeq, PubMed]; Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity., [RefSeq, PubMed]; RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 21, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O08948;Q63728", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0031223 auditory behavior;GO:0001964 startle response;GO:0051707 response to other organism;GO:0071359 cellular response to dsRNA;GO:1904880 response to hydrogen sulfide", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q00959-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05708-1", "uniprot_id": [ { "id": "HXK1_RAT", "url": "https://www.uniprot.org/uniprot/P05708", "type": "external" } ], "mass": 102408.0, "length": 918, "protein_name": "Hexokinase-1", "gene_name": "Hk1", "organism": "Rat", "refseq_name": "hexokinase-1 isoform 2", "refseq_ac": [ { "id": "NP_036866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036866", "type": "external" } ], "gene_names_uniprotkb": "Hk1", "gene_names_refseq": "HEXOKIN; HKI; Hk1", "protein_names_uniprotkb": "Hexokinase-1; 2.7.1.1; Brain form hexokinase; HK I; Hexokinase type I; Hexokinase-A", "protein_names_refseq": "brain form hexokinase; hexokinase type I; hexokinase-1 isoform 2; hexokinase-A", "tax_id": 10116, "disease": "congenital nonspherocytic hemolytic anemia 5 (Disease Ontology:DOID:0051006); retinitis pigmentosa 79 (Disease Ontology:DOID:0061108); Charcot-Marie-Tooth disease type 4G (Disease Ontology:DOID:0110196); retinitis pigmentosa (Disease Ontology:DOID:10584); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); anemia (Disease Ontology:DOID:2355); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); glucose metabolism disease (Disease Ontology:DOID:4194); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25058)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "13211595;18683930;19423663;22673903;2704734;28100784;32113849;32283307;3277968;34948127;3579310;3631958;39261628;5871820;7044667;9665168", "class_list": "", "function": "Alpha-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease., [RefSeq, PubMed]; Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:13211595, PubMed:3579310, PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:13211595, PubMed:5871820). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (By similarity). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina., [RefSeq, PubMed]; The HDAC Inhibitor Butyrate Impairs beta Cell Function and Activates the Disallowed Gene Hexokinase I. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0042834 peptidoglycan binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005929 cilium;GO:0045121 membrane raft", "go_biological_process": "GO:1901986 response to ketamine;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation;GO:0006954 inflammatory response;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P05708-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35077-1", "uniprot_id": [ { "id": "GPDA_RAT", "url": "https://www.uniprot.org/uniprot/O35077", "type": "external" } ], "mass": 37453.0, "length": 349, "protein_name": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "gene_name": "Gpd1", "organism": "Rat", "refseq_name": "glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic", "refseq_ac": [ { "id": "NP_071551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071551", "type": "external" } ], "gene_names_uniprotkb": "Gpd1", "gene_names_refseq": "GPDH; Gpd1; Gpd3", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; 1.1.1.8; GPD-C; GPDH-C", "protein_names_refseq": "GPD-C; GPDH-C; glycerol 3-phosphate dehydrogenase; glycerol-3-phosphate dehydrogenase 1 (soluble); glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic", "tax_id": 10116, "disease": "", "pathway": " (rno:60666); (R-RNO-1483166)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18952046;20886417;22673903;23124204;9237667", "class_list": "", "function": "GPDH expression was significantly increased in the hyperthyroid and decreased in the hyporthyroid status in both sexes., [RefSeq, PubMed]; Has glycerol-3-phosphate dehydrogenase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; High efficiency of mGPDH-dependent ROS production in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT., [RefSeq, PubMed]; These results clarify the maximum rate and mechanism of superoxide production by mGPDH., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0F4", "ec_number_list": [ { "id": "1.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding;GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity;GO:0141152 glycerol-3-phosphate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006127 glycerol-3-phosphate shuttle;GO:0071320 cellular response to cAMP;GO:0006094 gluconeogenesis;GO:0045821 positive regulation of glycolytic process;GO:0071356 cellular response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35077-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35095-1", "uniprot_id": [ { "id": "NCDN_RAT", "url": "https://www.uniprot.org/uniprot/O35095", "type": "external" } ], "mass": 78923.0, "length": 729, "protein_name": "Neurochondrin", "gene_name": "Ncdn", "organism": "Rat", "refseq_name": "neurochondrin", "refseq_ac": [ { "id": "NP_445995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445995", "type": "external" } ], "gene_names_uniprotkb": "Ncdn", "gene_names_refseq": "Ncdn; Norbin", "protein_names_uniprotkb": "Neurochondrin; Neurite outgrowth-related protein from the rat brain; Norbin", "protein_names_refseq": "neurite outgrowth-related protein from the rat brain; neurochondrin", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:89791)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10521593;18572016;18683930;20007903;22673903;23687301;24670218;29070854;29393594;37880240;9398642", "class_list": "", "function": "Low norbin expression is associated with Epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Neurochondrin is a novel Dia1 interacting protein., [RefSeq, PubMed]; Norbin associates with actin rather than with PSD-95 in dendritic spines. Publication Status: Online-Only, [RefSeq, PubMed]; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth., [UniProtKB, PubMed]; The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQW2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031175 neuron projection development;GO:0045453 bone resorption;GO:0048168 regulation of neuronal synaptic plasticity;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35095-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88759-1", "uniprot_id": [ { "id": "KCNS3_RAT", "url": "https://www.uniprot.org/uniprot/O88759", "type": "external" } ], "mass": 55866.0, "length": 491, "protein_name": "Delayed-rectifier potassium channel regulatory subunit KCNS3", "gene_name": "Kcns3", "organism": "Rat", "refseq_name": "delayed-rectifier potassium channel regulatory subunit KCNS3", "refseq_ac": [ { "id": "NP_113966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113966", "type": "external" } ], "gene_names_uniprotkb": "Kcns3", "gene_names_refseq": "Kcns3; Kv9.3", "protein_names_uniprotkb": "Delayed-rectifier potassium channel regulatory subunit KCNS3; Delayed-rectifier K(+) channel alpha subunit 3; Delayed-rectifier potassium channel subunit Kv9.3; Kv9.3; Potassium voltage-gated channel subfamily S member 3", "protein_names_refseq": "Shab-related delayed-rectifier K+ channel (Kv9.3); delayed-rectifier K(+) channel alpha subunit 3; delayed-rectifier potassium channel regulatory subunit KCNS3; delayed-rectifier potassium channel subunit Kv9.3; potassium voltage-gated channel subfamily S member 3; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3; voltage-gated potassium channel subunit Kv9.3", "tax_id": 10116, "disease": "", "pathway": " (rno:83588); (R-RNO-1296072); (R-RNO-381676)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12744302;9362476;9704029", "class_list": "", "function": "Different Kv9.3/Kv2.1 ratios could have physiological implications in lung and brain during post-natal development, and that diet composition and selective tissue-specific insulin regulation modulate the expression of Kv2.1 and Kv9.3., [RefSeq, PubMed]; Potassium channel regulatory subunit that modulates the delayed rectifier potassium channel activity of KCNB1 by namely slowing down the deactivation and inactivation time constants (PubMed:9362476). While it does not form functional channel on its own, it can form functional heterotetrameric channels with KCNB1 (PubMed:9362476)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54900", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88759-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03994-1", "uniprot_id": [ { "id": "HPLN1_RAT", "url": "https://www.uniprot.org/uniprot/P03994", "type": "external" } ], "mass": 40262.0, "length": 354, "protein_name": "Hyaluronan and proteoglycan link protein 1", "gene_name": "Hapln1", "organism": "Rat", "refseq_name": "hyaluronan and proteoglycan link protein 1 precursor", "refseq_ac": [ { "id": "NP_001426336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426336", "type": "external" } ], "gene_names_uniprotkb": "Hapln1; Crtl1", "gene_names_refseq": "Crtl1; Hapln1", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; Cartilage-linking protein 1; Proteoglycan link protein", "protein_names_refseq": "LP; cartilage link protein 1; cartilage-link protein; cartilage-linking protein 1; hyaluronan and proteoglycan link protein 1 precursor; proteoglycan link protein", "tax_id": 10116, "disease": "spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (R-RNO-3000178)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12586755;2419334;2452158;3459153;36737556;38580957", "class_list": "", "function": "HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing., [RefSeq, PubMed]; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix., [UniProtKB]; Study represents the first report that follicle stimulating hormone amplifies insulin-like growth factor-I-mediated cartilage link protein Crtl1 production, possibly via phosphatidylinositol 3-kinase-Akt signaling cascades in rat granulosa cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0045202 synapse;GO:0072534 perineuronal net;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P03994-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07727-1", "uniprot_id": [ { "id": "GLRA1_RAT", "url": "https://www.uniprot.org/uniprot/P07727", "type": "external" } ], "mass": 52617.0, "length": 457, "protein_name": "Glycine receptor subunit alpha-1", "gene_name": "Glra1", "organism": "Rat", "refseq_name": "glycine receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_037265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037265", "type": "external" } ], "gene_names_uniprotkb": "Glra1; Glyr", "gene_names_refseq": "GLYRA1; Glra1", "protein_names_uniprotkb": "Glycine receptor subunit alpha-1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit", "protein_names_refseq": "glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1 precursor; glycine receptor subunit alpha-1; glycine receptor, alpha 1 subunit", "tax_id": 10116, "disease": "hyperekplexia (Disease Ontology:DOID:0060695); hyperekplexia 1 (Disease Ontology:DOID:0060696)", "pathway": " (rno:25674); (R-RNO-112314)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11981023;14551753;1703015;1703526;1716350;2171639;2483325;27226610;28026001;3037383;34802146;38017313;6286620", "class_list": "", "function": "Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish alpha1 and rat alpha1beta recombinant glycine receptors., [RefSeq, PubMed]; Gain-of-function GLRA1 mutations also cause hyperekplexia, although the mechanism is unknown. Here we identify two new gain-of-function mutations (I43F and W170S) and characterize these along with known gain-of-function mutations (Q226E, V280M, and R414H) to identify how they cause hyperekplexia., [RefSeq, PubMed]; Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy., [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:11981023, PubMed:1716350, PubMed:2483325, PubMed:3037383). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The role of gephyrin and glycine receptor (GlyR) in vestibular compensation, was investigated., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q546L6", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0030977 taurine binding;GO:0004888 transmembrane signaling receptor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0044305 calyx of Held;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0001964 startle response;GO:0051970 negative regulation of transmission of nerve impulse;GO:0060012 synaptic transmission, glycinergic;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07727-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13234-1", "uniprot_id": [ { "id": "KCC4_RAT", "url": "https://www.uniprot.org/uniprot/P13234", "type": "external" } ], "mass": 53151.0, "length": 474, "protein_name": "Calcium/calmodulin-dependent protein kinase type IV", "gene_name": "Camk4", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type IV", "refseq_ac": [ { "id": "NP_036859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036859", "type": "external" } ], "gene_names_uniprotkb": "Camk4", "gene_names_refseq": "Camk4; Ccdpk; RATCCDPK", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type IV; 2.7.11.17; CaM kinase-GR; CaMK IV; Calspermin", "protein_names_refseq": "CAM kinase-GR; Calmodulin-dependent protein kinase IV; caMK IV; calcium/calmodulin-dependent protein kinase type IV; calspermin", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:25050); (R-RNO-111932); (R-RNO-442729)", "pathway_count": 3, "publication_count": 28, "publication_id_list": "10336483;14701808;1646483;1648230;1649385;19486109;19874424;22673903;23817991;2538431;26649942;27216039;28592691;2914893;34586897;7493991;7592527;7615569;7961813;8065343;8340352;8412563;8621702;8631893;8636117;8855261;9596578;9822657", "class_list": "", "function": "CaMK4 is a downstream effector of the alpha1G T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity)., [UniProtKB]; Heat-stable, acidic, calmodulin-binding protein., [UniProtKB, PubMed, PubMed, PubMed]; Study demonstrates that CaMKIV can relieve STZ-induced diabetic neuropathic pain.pCaMKIV can regulate the expression of High-mobility group box 1 based on both cellular and animal models. Publication Status: Online-Only, [RefSeq, PubMed]; We find that synaptic excitation and intrinsic excitability are coregulated in individual neurons through CaMKIV signaling, which is tightly controlled by neuronal activity. In contrast, synaptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons., [RefSeq, PubMed]; We have determined that high levels of CaMKIV protein are expressed by IB4-binding sensory neurons of the dorsal root ganglion, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A1A5L5;Q63892", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P13234-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15383-1", "uniprot_id": [ { "id": "KCNE1_RAT", "url": "https://www.uniprot.org/uniprot/P15383", "type": "external" } ], "mass": 14699.0, "length": 130, "protein_name": "Potassium voltage-gated channel subfamily E member 1", "gene_name": "Kcne1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily E member 1", "refseq_ac": [ { "id": "NP_037105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037105", "type": "external" } ], "gene_names_uniprotkb": "Kcne1", "gene_names_refseq": "Isk; Kcne1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; MinK; Minimal potassium channel", "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit beta Mink; delayed rectifier potassium channel subunit IsK; minimal potassium channel; mink; potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); long QT syndrome 5 (Disease Ontology:DOID:0110647); primary biliary cholangitis (Disease Ontology:DOID:12236); autoimmune hepatitis (Disease Ontology:DOID:2048); Jervell-Lange Nielsen syndrome (Disease Ontology:DOID:2842); long QT syndrome (Disease Ontology:DOID:2843); seminoma (Disease Ontology:DOID:4440); congestive heart failure (Disease Ontology:DOID:6000); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25471)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "14679187;1553557;19219384;2183220;2229022;2344412;28064310;28611207;3194754;34907346;7605639", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (By similarity)., [UniProtKB, PubMed, UniProtKB]; In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress., [RefSeq, PubMed]; Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression. Publication Status: Online-Only, [RefSeq, PubMed]; Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0044877 protein-containing complex binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P15383-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17325-1", "uniprot_id": [ { "id": "JUN_RAT", "url": "https://www.uniprot.org/uniprot/P17325", "type": "external" } ], "mass": 36001.0, "length": 334, "protein_name": "Transcription factor Jun", "gene_name": "Jun", "organism": "Rat", "refseq_name": "transcription factor Jun", "refseq_ac": [ { "id": "NP_068607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068607", "type": "external" } ], "gene_names_uniprotkb": "Jun; Rjg-9", "gene_names_refseq": "Jun", "protein_names_uniprotkb": "Transcription factor Jun; AP1; Activator protein 1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog", "protein_names_refseq": "AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; V-jun avian sarcoma virus 17 oncogene homolog; activator protein 1; proto-oncogene c-jun; transcription factor AP-1 subunit Jun; transcription factor AP-1; transcription factor Jun; v-jun sarcoma virus 17 oncogene homolog", "tax_id": 10116, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate carcinoma (Disease Ontology:DOID:10286); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); pulmonary tuberculosis (Disease Ontology:DOID:2957); renal cell carcinoma (Disease Ontology:DOID:4450); renal carcinoma (Disease Ontology:DOID:4451); Hodgkin's lymphoma (Disease Ontology:DOID:8567); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24516); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450341); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "1310930;1749429;20852630;2113275;22673903;2507134;27458189;30012597;35906072;36713029;9154808", "class_list": "", "function": "JUN Regulation of Injury-Induced Enhancers in Schwann Cells., [RefSeq, PubMed]; RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005096 GTPase activator activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0051365 cellular response to potassium ion starvation;GO:0019046 release from viral latency;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P17325-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18420-1", "uniprot_id": [ { "id": "PSA1_RAT", "url": "https://www.uniprot.org/uniprot/P18420", "type": "external" } ], "mass": 29518.0, "length": 263, "protein_name": "Proteasome subunit alpha type-1", "gene_name": "Psma1", "organism": "Rat", "refseq_name": "proteasome subunit alpha type-1", "refseq_ac": [ { "id": "NP_058974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058974", "type": "external" } ], "gene_names_uniprotkb": "Psma1", "gene_names_refseq": "Psma1", "protein_names_uniprotkb": "Proteasome subunit alpha type-1; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chain", "protein_names_refseq": "macropain subunit C2; multicatalytic endopeptidase complex subunit C2; proteasome (prosome, macropain) subunit, alpha type 1; proteasome alpha 1 subunit; proteasome component C2; proteasome nu chain; proteasome subunit alpha 1; proteasome subunit alpha type-1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29668); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 2, "publication_id_list": "2335242;2819072", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18420-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19836-1", "uniprot_id": [ { "id": "PCY1A_RAT", "url": "https://www.uniprot.org/uniprot/P19836", "type": "external" } ], "mass": 41681.0, "length": 367, "protein_name": "Choline-phosphate cytidylyltransferase A", "gene_name": "Pcyt1a", "organism": "Rat", "refseq_name": "choline-phosphate cytidylyltransferase A", "refseq_ac": [ { "id": "NP_511177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511177", "type": "external" } ], "gene_names_uniprotkb": "Pcyt1a; Ctpct; Pcyt1", "gene_names_refseq": "CCT-alpha; CTP; Pcyt1a", "protein_names_uniprotkb": "Choline-phosphate cytidylyltransferase A; 2.7.7.15; CCT A; CCT-alpha; CT A; CTP:phosphocholine cytidylyltransferase A; Phosphorylcholine transferase A", "protein_names_refseq": "CCT A; CT A; CTP:phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha; choline phosphate cytidylyltransferase 1 alpha; choline-phosphate cytidylyltransferase A-like; choline-phosphate cytidylyltransferase A; phosphate cytidylyltransferase 1, choline, alpha; phosphorylcholine transferase A", "tax_id": 10116, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); spondylometaphyseal dysplasia with cone-rod dystrophy (Disease Ontology:DOID:0112300)", "pathway": " (rno:140544); (R-RNO-1483191)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12718547;19783652;21504799;2166941;22673903;22988242;23155050;24275660;27032756;639816;8144639;8185307;8381041;8810902", "class_list": "", "function": "127 fibroblasts was heterogeneous, with evidence of nucleoplasmic, cytoplasmic and NE staining., [RefSeq, PubMed]; Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Data show that exogenous prostaglandin D2 (PGD2) induces CTP:phosphocholine cytidylyltransferase alpha (CCTalpha) distribution to nuclear envelope from intranuclear Lamin A/C foci., [RefSeq, PubMed]; Ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase alpha contributes to malignant transformation of intestinal epithelial cells, [RefSeq, PubMed]; The 22-mer segment in the structurally pliable regulatory domain of rat CTP: phosphocholine cytidylyltransferase facilitates both silencing and activating functions, [RefSeq, PubMed]; This work deciphers how the CCT regulatory amphipathic helix functions as a silencing device., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.15", "type": "external" } ], "go_molecular_function": "GO:0004105 choline-phosphate cytidylyltransferase activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0006656 phosphatidylcholine biosynthetic process;GO:0045190 isotype switching;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P19836-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20781-1", "uniprot_id": [ { "id": "GLRB_RAT", "url": "https://www.uniprot.org/uniprot/P20781", "type": "external" } ], "mass": 55927.0, "length": 496, "protein_name": "Glycine receptor subunit beta", "gene_name": "Glrb", "organism": "Rat", "refseq_name": "glycine receptor subunit beta precursor", "refseq_ac": [ { "id": "NP_445748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445748", "type": "external" } ], "gene_names_uniprotkb": "Glrb", "gene_names_refseq": "Glrb", "protein_names_uniprotkb": "Glycine receptor subunit beta; Glycine receptor 58 kDa subunit", "protein_names_refseq": "glycine receptor 58 kDa subunit; glycine receptor subunit beta precursor; glycine receptor subunit beta; glycine receptor, beta subunit", "tax_id": 10116, "disease": "hyperekplexia 2 (Disease Ontology:DOID:0060697)", "pathway": " (rno:25456); (R-RNO-112314)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "14551753;15201864;15574743;16511563;2163264;22592841;22673903;24509844;28026001;29464196;34802146;38017313;8581315", "class_list": "", "function": "Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish alpha1 and rat alpha1beta recombinant glycine receptors., [RefSeq, PubMed]; Streptozotocin-Induced Diabetic Rats Showed a Differential Glycine Receptor Expression in the Spinal Cord: A GlyR Role in Diabetic Neuropathy., [RefSeq, PubMed]; Study shows that the glycine receptors beta-loop sequences flanking the core-binding site differentially regulate the affinity of the receptor for gephyrin and its trapping at synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of heteromeric glycine-gated chloride channels (PubMed:15574743). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; The SdpI-binding site was mapped to a proline-rich sequence of 22 amino acids within the intracellular loop of GlyRbeta., [RefSeq, PubMed]; The role of gephyrin and glycine receptor (GlyR) in vestibular compensation, was investigated., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016933 extracellularly glycine-gated ion channel activity;GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0044877 protein-containing complex binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0001964 startle response;GO:0060012 synaptic transmission, glycinergic;GO:0006811 monoatomic ion transport;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P20781-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21213-1", "uniprot_id": [ { "id": "HUTH_RAT", "url": "https://www.uniprot.org/uniprot/P21213", "type": "external" } ], "mass": 72284.0, "length": 657, "protein_name": "Histidine ammonia-lyase", "gene_name": "Hal", "organism": "Rat", "refseq_name": "histidine ammonia-lyase", "refseq_ac": [ { "id": "NP_058855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058855", "type": "external" } ], "gene_names_uniprotkb": "Hal; Huth", "gene_names_refseq": "Hal; histidase", "protein_names_uniprotkb": "Histidine ammonia-lyase; 4.3.1.3; Histidase", "protein_names_refseq": "histidine ammonia-lyase", "tax_id": 10116, "disease": "histidinemia (Disease Ontology:DOID:0060168)", "pathway": " (rno:29301); (R-RNO-70921)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15741241;2120224;22673903;7961661", "class_list": "", "function": "This evidence supports that the Hal gene is turned on by glucocorticoids and by glucagon either via PKC or PKA, but prefers the PKA pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB8", "ec_number_list": [ { "id": "4.3.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.3", "type": "external" } ], "go_molecular_function": "GO:0004397 histidine ammonia-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process;GO:0006547 L-histidine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21213-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22462-1", "uniprot_id": [ { "id": "KCNC2_RAT", "url": "https://www.uniprot.org/uniprot/P22462", "type": "external" } ], "mass": 70191.0, "length": 638, "protein_name": "Voltage-gated potassium channel KCNC2", "gene_name": "Kcnc2", "organism": "Rat", "refseq_name": "voltage-gated potassium channel KCNC2 isoform a", "refseq_ac": [ { "id": "NP_631962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631962", "type": "external" } ], "gene_names_uniprotkb": "Kcnc2", "gene_names_refseq": "KShIIIA; Kcnc2; Kv3.2", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC2; Potassium channel voltage-gated Shaw-related subfamily C member 2; Potassium voltage-gated channel subfamily C member 2; Shaw-like potassium channel; Voltage-gated potassium channel subunit Kv3.2", "protein_names_refseq": "potassium channel voltage-gated Shaw-related subfamily C member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; shaw-like potassium channel; voltage-gated potassium channel KCNC2 isoform a; voltage-gated potassium channel KCNC2; voltage-gated potassium channel subunit Kv3.2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 103 (Disease Ontology:DOID:0070389); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (rno:246153); (R-RNO-1296072); (R-RNO-381676)", "pathway_count": 3, "publication_count": 19, "publication_id_list": "10414303;10414968;10482766;11281123;11506885;1374908;1378392;14679187;16413129;18708127;18775767;1879548;19332619;2023956;22831914;2367536;7643197;8120636;9307441", "class_list": "", "function": "In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10414968, PubMed:10482766, PubMed:11506885, PubMed:22831914). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:10414303, PubMed:10482766, PubMed:11281123, PubMed:14679187, PubMed:1879548, PubMed:2367536, PubMed:7643197, PubMed:8120636). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1879548, PubMed:2367536, PubMed:7643197, PubMed:8120636). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10482766, PubMed:14679187). Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (PubMed:11281123, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:10414968, PubMed:10482766, PubMed:11506885, PubMed:22831914). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P22461;P22463;Q63735", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:1990089 response to nerve growth factor;GO:0045471 response to ethanol;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P22462-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22791-1", "uniprot_id": [ { "id": "HMCS2_RAT", "url": "https://www.uniprot.org/uniprot/P22791", "type": "external" } ], "mass": 56886.0, "length": 508, "protein_name": "Hydroxymethylglutaryl-CoA synthase, mitochondrial", "gene_name": "Hmgcs2", "organism": "Rat", "refseq_name": "hydroxymethylglutaryl-CoA synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_775117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775117", "type": "external" } ], "gene_names_uniprotkb": "Hmgcs2", "gene_names_refseq": "Hmgcs1; Hmgcs2; Mt3h3mg", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, mitochondrial; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutary-Coenzyme A synthase 2; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 2; hydroxymethylglutaryl-CoA synthase, mitochondrial precursor; hydroxymethylglutaryl-CoA synthase, mitochondrial", "tax_id": 10116, "disease": "HMG-CoA synthase 2 deficiency (Disease Ontology:DOID:0081168); extrahepatic cholestasis (Disease Ontology:DOID:13619); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:24450); (R-RNO-77111); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "1971108;22673903;27671501;36281857;38477658;8097464", "class_list": "", "function": "Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA., [UniProtKB, UniProtKB]; Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hmgcs2 is the hub gene in diabetic cardiomyopathy and is negatively regulated by Hmgcs2, promoting high glucose-induced cardiomyocyte injury., [RefSeq, PubMed]; Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries., [RefSeq, PubMed]; Results identify 3-hydroxy-3-methylglutaryl coenzyme A synthase isoenzymes 1 and 2 as the alternative markers for satellite glial cells (SGCs) in dorsal root ganglia (DRGs). Downregulated HMGCS1 expression in DRGs after spinal nerve injury may reflect a potential role of abnormal sterol metabolism of SGCs in the nerve injured-induced neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M9Q5;Q68G44", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0001889 liver development;GO:0007584 response to nutrient;GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P22791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24524-1", "uniprot_id": [ { "id": "GLRA3_RAT", "url": "https://www.uniprot.org/uniprot/P24524", "type": "external" } ], "mass": 53672.0, "length": 464, "protein_name": "Glycine receptor subunit alpha-3", "gene_name": "Glra3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Glra3", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycine receptor subunit alpha-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:114516); (R-RNO-112314)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15131310;19723286;2176214;23613537;23834509;23895467;25445488", "class_list": "", "function": "Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:23613537, PubMed:23834509, PubMed:23895467). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (PubMed:25445488). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (PubMed:23895467)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0022852 glycine-gated chloride ion channel activity;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016935 glycine-gated chloride channel complex;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0097688 glutamate receptor clustering;GO:0051260 protein homooligomerization;GO:0071361 cellular response to ethanol;GO:1902476 chloride transmembrane transport;GO:0071230 cellular response to amino acid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24524-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25122-1", "uniprot_id": [ { "id": "KCNC1_RAT", "url": "https://www.uniprot.org/uniprot/P25122", "type": "external" } ], "mass": 65857.0, "length": 585, "protein_name": "Voltage-gated potassium channel KCNC1", "gene_name": "Kcnc1", "organism": "Rat", "refseq_name": "voltage-gated potassium channel KCNC1", "refseq_ac": [ { "id": "NP_036988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036988", "type": "external" } ], "gene_names_uniprotkb": "Kcnc1", "gene_names_refseq": "KShIIIB; Kcnc1; Kv3.1; Kv4; NGK2-KV4", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC1; NGK2; Potassium voltage-gated channel subfamily C member 1; RAW2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4", "protein_names_refseq": "NGK2; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); RAW2; potassium channel, voltage gated Shaw-related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; voltage-gated potassium channel KCNC1; voltage-gated potassium channel subunit Kv3.1; voltage-gated potassium channel subunit Kv4", "tax_id": 10116, "disease": "mirror movements 3 (Disease Ontology:DOID:0070639); progressive myoclonus epilepsy 7 (Disease Ontology:DOID:0111447)", "pathway": " (rno:25327); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10482766;1378392;14679187;16595659;2023941;20857303;22673903;24161696;24291260;26348848;28213922;28322444", "class_list": "", "function": "Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels., [RefSeq, PubMed]; This study demonstrated that Kv3.1b potassium channel expression in motor cortex pyramidal cells., [RefSeq, PubMed]; Trafficking-dependent roles of the Kv3.1b potassium channel are dependent on N229 site-specific glycosylation and N-glycan structure, and operate through a mechanism whereby specific N-glycan structures regulate cell surface expression., [RefSeq, PubMed]; Voltage-gated potassium channel that opens in response to the voltage difference across the membrane and through which potassium ions pass in accordance with their electrochemical gradient (Probable) (PubMed:10482766, PubMed:1378392, PubMed:14679187). The mechanism is time-dependent and inactivation is slow (PubMed:10482766, PubMed:1378392). Plays an important role in the rapid repolarization of fast-firing brain neurons (PubMed:10482766). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0019894 kinesin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0032589 neuron projection membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:1990089 response to nerve growth factor;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25122-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27008-1", "uniprot_id": [ { "id": "PARP1_RAT", "url": "https://www.uniprot.org/uniprot/P27008", "type": "external" } ], "mass": 112660.0, "length": 1014, "protein_name": "Poly [ADP-ribose] polymerase 1", "gene_name": "Parp1", "organism": "Rat", "refseq_name": "poly [ADP-ribose] polymerase 1", "refseq_ac": [ { "id": "NP_037195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037195", "type": "external" } ], "gene_names_uniprotkb": "Parp1; Adprt", "gene_names_refseq": "ARTD1; Adprt; Parp-1; Parp1", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; Poly [ADP-ribose] polymerase 1, 24-kDa form; Poly [ADP-ribose] polymerase 1, 89-kDa form; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1", "protein_names_refseq": "ADP-ribosyltransferase (NAD+; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase); poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase PARP-1; poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; protein poly-ADP-ribosyltransferase PARP1", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); middle cerebral artery infarction (Disease Ontology:DOID:3525); autoimmune disease (Disease Ontology:DOID:417); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); stomach carcinoma (Disease Ontology:DOID:5517); congestive heart failure (Disease Ontology:DOID:6000); arthritis (Disease Ontology:DOID:848); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470)", "pathway": " (rno:25591); (R-RNO-110362); (R-RNO-2173795); (R-RNO-3108214); (R-RNO-5685939); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696400)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "1601134;21967661;2508731;25625556;29393594;34020532;34738744;35002525;35190759;36728307;9385436", "class_list": "", "function": "PARP-1 Inhibition Repressed Imbalance of Th17 and Treg Cells in Preterm Rats with Intrauterine Infection-Induced Acute Respiratory Distress Syndrome by Reducing the Expression Level of IL-6. Publication Status: Online-Only, [RefSeq, PubMed]; PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function., [RefSeq, PubMed]; Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (By similarity). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (By similarity). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (By similarity). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR and NFAT5. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair. In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (By similarity). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II. Acts both as a positive and negative regulator of transcription elongation, depending on the context. Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing. Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9. Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (By similarity). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos. Also acts as a negative regulator of the cGAS-STING pathway. Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS. Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Plays a role in sister chromatid cohesion by mediating ADP-ribosylation of RSMC during S phase which promotes the interaction between RSMC and CDCA5/sororin, leading to enhanced interaction of CDCA5/sororin with the cohesin complex and promotion of sister chromatid cohesion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Precise Diabetic Wound Therapy: PLS Nanospheres Eliminate Senescent Cells via DPP4 Targeting and PARP1 Activation., [RefSeq, PubMed]; Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis., [UniProtKB, UniProtKB]; The cross-talk between PARylation and SUMOylation in C/EBPbeta at K134 site participates in pathological cardiac hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; The parp-1 and bax genes as potential targets for treatment of the heart functioning impairments induced by type 1 diabetes mellitus. Publication Status: Online-Only, [RefSeq, PubMed]; This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35937", "ec_number_list": [ { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:1904762 positive regulation of myofibroblast differentiation;GO:0016051 carbohydrate biosynthetic process;GO:0032700 negative regulation of interleukin-17 production;GO:0070213 protein auto-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P27008-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36970-1", "uniprot_id": [ { "id": "GPX4_RAT", "url": "https://www.uniprot.org/uniprot/P36970", "type": "external" } ], "mass": 22225.0, "length": 197, "protein_name": "Phospholipid hydroperoxide glutathione peroxidase", "gene_name": "Gpx4", "organism": "Rat", "refseq_name": "phospholipid hydroperoxide glutathione peroxidase isoform B", "refseq_ac": [ { "id": "NP_001034938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034938", "type": "external" } ], "gene_names_uniprotkb": "Gpx4", "gene_names_refseq": "Gpx4; Gshpx-4; Phgpx; gpx-4; snGpx", "protein_names_uniprotkb": "Phospholipid hydroperoxide glutathione peroxidase; 1.11.1.12; 1.11.1.9; GPx-4; GSHPx-4; Glutathione peroxidase 4; PHGPx", "protein_names_refseq": "phospholipid hydroperoxide glutathione peroxidase isoform B; phospholipid hydroperoxide glutathione peroxidase, mitochondrial; phospholipid hydroperoxide glutathione peroxidase, nuclear", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); spondylometaphyseal dysplasia Sedaghatian type (Disease Ontology:DOID:0112298); pre-eclampsia (Disease Ontology:DOID:10591); nephrotic syndrome (Disease Ontology:DOID:1184); colon cancer (Disease Ontology:DOID:219); acute kidney failure (Disease Ontology:DOID:3021); gastric adenocarcinoma (Disease Ontology:DOID:3717); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29328); (R-RNO-2142712); (R-RNO-2142770); (R-RNO-9018676); (R-RNO-9018896); (R-RNO-9020265); (R-RNO-9023661)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "10464096;10506188;10998361;11010961;11344099;12819198;14575705;1556123;19423663;22673903;38943181;39175261;39354361;7592947;8749327;9442035;9988735", "class_list": "", "function": "Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:1556123, PubMed:9988735). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB]; METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4., [RefSeq, PubMed]; Platelet-derived exosomes alleviate tendon stem/progenitor cell senescence and ferroptosis by regulating AMPK/Nrf2/GPX4 signaling and improve tendon-bone junction regeneration in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Rat Gpx4 is a moonlighting protein that functions both as a peroxidase, as well as a structural protein., [RefSeq, PubMed]; Required for male fertility by stabilizing the condensed chromatin in sperm nuclei., [UniProtKB, UniProtKB]; Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide (PubMed:11010961, PubMed:9442035)., [UniProtKB, PubMed, PubMed]; Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (PubMed:10506188, PubMed:10998361, PubMed:9988735). Also required for normal sperm development and male fertility (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. Pseudogenes of this locus have been identified on chromosomes 1, 10 and 14. [provided by RefSeq, Jan 2019]., [RefSeq]; The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PZ55;Q76LU9;Q91XR8", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004602 glutathione peroxidase activity;GO:0008430 selenium binding;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0016358 dendrite development;GO:0032496 response to lipopolysaccharide;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P36970-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51179-1", "uniprot_id": [ { "id": "NR4A3_RAT", "url": "https://www.uniprot.org/uniprot/P51179", "type": "external" } ], "mass": 68564.0, "length": 628, "protein_name": "Nuclear receptor subfamily 4 group A member 3", "gene_name": "Nr4a3", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 4 group A member 3", "refseq_ac": [ { "id": "NP_113816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113816", "type": "external" } ], "gene_names_uniprotkb": "Nr4a3; Nor1", "gene_names_refseq": "NOR-2; Nr4a3", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 3; Neuron-derived orphan receptor 1/2; Nuclear hormone receptor NOR-1/NOR-2", "protein_names_refseq": "neuron-derived orphan receptor 1/2; neuron-derived orphan receptor 1; nuclear hormone receptor NOR-1/NOR-2; nuclear receptor subfamily 4 group A member 3", "tax_id": 10116, "disease": "extraskeletal myxoid chondrosarcoma (Disease Ontology:DOID:4549)", "pathway": " (rno:58853); (R-RNO-383280)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10523643;15591535;16945922;19321449;24706823;25625556;27221116;33840679;38943627;7556683;7811288;7914660", "class_list": "", "function": "Loss of Nr4a1 and Nr4a3 impedes production of ATP and ultimately inhibits glucose-stimulated insulin secretion. These data demonstrate for the first time that the orphan nuclear receptors Nr4a1 and Nr4a3 are critical for beta-cell mitochondrial function and insulin secretion., [RefSeq, PubMed]; Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration., [RefSeq, PubMed]; Sequential preovulatory expression of a gonadotropin-releasing hormone-inducible gene, Nr4a3, and its suppressor Anxa5 in the pituitary gland of female rats., [RefSeq, PubMed]; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:7811288). Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (PubMed:10523643). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (By similarity). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression (PubMed:16945922). In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (PubMed:24706823). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). Also mediates survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (By similarity). Also plays a role in inflammation; Upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (By similarity). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation. Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP-glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (By similarity). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (By similarity). Also participates in cardiac hypertrophy by activating PARP1 (PubMed:25625556)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2XPY2;Q63516;Q9QWQ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0060005 vestibular reflex;GO:2000108 positive regulation of leukocyte apoptotic process;GO:0048752 semicircular canal morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P51179-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56536-1", "uniprot_id": [ { "id": "KIF5C_RAT", "url": "https://www.uniprot.org/uniprot/P56536", "type": "external" } ], "mass": 109182.0, "length": 955, "protein_name": "Kinesin heavy chain isoform 5C", "gene_name": "Kif5c", "organism": "Rat", "refseq_name": "kinesin heavy chain isoform 5C", "refseq_ac": [ { "id": "NP_001101200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101200", "type": "external" } ], "gene_names_uniprotkb": "Kif5c; Nkhc2", "gene_names_refseq": "Kif5c", "protein_names_uniprotkb": "Kinesin heavy chain isoform 5C; 3.6.4.-; Kinesin heavy chain neuron-specific 2; Kinesin-1", "protein_names_refseq": "kinesin heavy chain isoform 5C; kinesin heavy chain neuron-specific 2; kinesin-1", "tax_id": 10116, "disease": "complex cortical dysplasia with other brain malformations 2 (Disease Ontology:DOID:0090133); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); leiomyoma (Disease Ontology:DOID:127); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:311024)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11319135;22673903;23576431;27452403;27699600;28302907;31084716;34348158;36675068;9405049;9428521", "class_list": "", "function": "A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression., [RefSeq, PubMed]; Cargo recognition and concurrent activation of kinesin-1 proceed in hierarchical stepwise fashion driven by a dynamic network of inter- and intra-molecular interactions., [RefSeq, PubMed]; Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-associated force-producing protein that may play a role in organelle transport (By similarity). Has ATPase activity (PubMed:27452403). Involved in synaptic transmission (By similarity). Mediates dendritic trafficking of mRNAs (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; These results demonstrate that the neck linker serves as a mechanical element for kinesin-1 transport under physiological conditions. Publication Status: Online-Only, [RefSeq, PubMed]; We conclude that the enrichment of stable microtubules in the future axon enhances KIF5C-mediated vesicular transport of syntaxin 6 and VAMP4, which in turn mediates the polarized insertion of IGF-1r in the plasmalemma, a key step for neuronal polarization, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V6L4", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0034190 apolipoprotein receptor binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030425 dendrite;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0008045 motor neuron axon guidance;GO:0008298 intracellular mRNA localization;GO:0051028 mRNA transport;GO:0098964 anterograde dendritic transport of messenger ribonucleoprotein complex", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P56536-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59215-1", "uniprot_id": [ { "id": "GNAO_RAT", "url": "https://www.uniprot.org/uniprot/P59215", "type": "external" } ], "mass": 40069.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(o) subunit alpha", "gene_name": "Gnao1", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(o) subunit alpha isoform B", "refseq_ac": [ { "id": "NP_059023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059023", "type": "external" } ], "gene_names_uniprotkb": "Gnao1; Gna0; Gnao", "gene_names_refseq": "Gnao1; Gnao; Hg1g; RATBPGTPC", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(o) subunit alpha; 3.6.5.-", "protein_names_refseq": "GTP-binding protein alpha o; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha O polypeptide 1; guanine nucleotide-binding protein G(o) subunit alpha isoform B; guanine nucleotide-binding protein G(o) subunit alpha; heterotrimeric guanine nucleotide-binding protein 1g", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 17 (Disease Ontology:DOID:0080450); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); neurodevelopmental disorder with involuntary movements (Disease Ontology:DOID:0112276); McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:50664); (R-RNO-4086398)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "1901650;2158629;26620557;2820999;3086867;31155309;35839930;38843836;8484716;9990023", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway., [RefSeq, PubMed]; Structure, function, and dynamics of the Galpha binding domain of Ric-8A have been reported., [RefSeq, PubMed]; The regulatory role of Gnao1 protein in diabetic encephalopathy in KK-Ay mice and streptozotocin-induced diabetic rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04900;P30033", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0030900 forebrain development;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P59215-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63144-1", "uniprot_id": [ { "id": "KCAB1_RAT", "url": "https://www.uniprot.org/uniprot/P63144", "type": "external" } ], "mass": 44710.0, "length": 401, "protein_name": "Voltage-gated potassium channel subunit beta-1", "gene_name": "Kcnab1", "organism": "Rat", "refseq_name": "voltage-gated potassium channel subunit beta-1", "refseq_ac": [ { "id": "NP_058999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058999", "type": "external" } ], "gene_names_uniprotkb": "Kcnab1; Kvb1", "gene_names_refseq": "Kcnab1; KvBeta3", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-1; 1.1.1.-; K(+) channel subunit beta-1; Kv-beta-1", "protein_names_refseq": "K(+) channel subunit beta-1; Kvbeta1.1; Kvbeta1.2; Kvbeta1.3; kv-beta-1; potassium channel, voltage gated subfamily A regulatory beta subunit 1; potassium channel, voltage-gated shaker related subfamily A regulatory beta subunit 1; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel beta subunit; voltage-gated potassium channel subunit beta-1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:29737); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10064591;10477520;10650996;15618540;16504945;18222921;18650555;19713757;19780818;21436029;33168717;8183366;9334400", "class_list": "", "function": "A structural model of fatty acid (lithocholate) insertion and docking onto specific Kcnab1 transmembrane domain 2 interface regions is postulated that explains the differential efficacy of bile acids on large channel activity., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (By similarity). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:10650996, PubMed:15618540, PubMed:16504945, PubMed:18222921, PubMed:8183366). Promotes the inactivation of KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6 alpha subunit-containing channels (PubMed:10064591, PubMed:10650996, PubMed:15618540, PubMed:16504945, PubMed:8183366). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (PubMed:18222921). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:18222921). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (PubMed:18222921, PubMed:21436029)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; The potassium channel subunit Kvbeta1 serves as a major control point for synaptic facilitation., [RefSeq, PubMed]; The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97380;Q5FWS9;Q61763;Q63277", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" } ], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0070402 NADPH binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007507 heart development;GO:0007611 learning or memory;GO:1902260 negative regulation of delayed rectifier potassium channel activity;GO:0045445 myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P63144-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70604-1", "uniprot_id": [ { "id": "KCNN2_RAT", "url": "https://www.uniprot.org/uniprot/P70604", "type": "external" } ], "mass": 63848.0, "length": 580, "protein_name": "Small conductance calcium-activated potassium channel protein 2", "gene_name": "Kcnn2", "organism": "Rat", "refseq_name": "small conductance calcium-activated potassium channel protein 2 isoform 2", "refseq_ac": [ { "id": "NP_062187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062187", "type": "external" } ], "gene_names_uniprotkb": "Kcnn2", "gene_names_refseq": "KCa2.2; Kcnn2; SK2; SKCa 2; SKCa2", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein 2; KCa2.2; SK2; SKCa 2; SKCa2", "protein_names_refseq": "potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel protein 2 isoform 2; small conductance calcium-activated potassium channel protein 2-like; small conductance calcium-activated potassium channel protein 2", "tax_id": 10116, "disease": "myoclonic dystonia 34 (Disease Ontology:DOID:0060957); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); essential tremor (Disease Ontology:DOID:4990)", "pathway": " (rno:54262); (R-RNO-1296052)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11323678;11325723;16641100;20562108;21422289;30771223;31001092;34774547;36717104;37466411;8781233;9774106", "class_list": "", "function": "KCa 2.2 (KCNN2): A physiologically and therapeutically important potassium channel. Review article, [RefSeq, PubMed]; Loss-of-function KCa2.2 mutations abolish channel activity., [RefSeq, PubMed]; RSK1 appears to act as chaperone for rSK2 channels and expression of rSK1 may control the level of functional SK current in rat neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11325723, PubMed:20562108, PubMed:21422289, PubMed:8781233, PubMed:9774106). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (PubMed:8781233, PubMed:9774106). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:8781233, PubMed:9774106). The inward rectification could be due to a blockade of the outward current by intracellular divalent cations such as calcium and magnesium and could also be due to an intrinsic property of the channel pore, independent of intracellular divalent ions (PubMed:11325723, PubMed:21422289). There are three positively charged amino acids in the S6 transmembrane domain, close to the pore, that collectively control the conductance and rectification through an electrostatic mechanism (PubMed:21422289). Additionally, electrostatic contributions from these residues also play an important role in determining the intrinsic open probability of the channel in the absence of calcium, affecting the apparent calcium affinity for activation (PubMed:21422289). Forms an heteromeric complex with calmodulin, which is constitutively associated in a calcium-independent manner (PubMed:9774106). Channel opening is triggered when calcium binds the calmodulin resulting in a rotary movement leading to the formation of the dimeric complex to open the gate (PubMed:11323678, PubMed:9774106). Plays a role in the repolarization phase of cardiac action potential (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0006811 monoatomic ion transport;GO:0043268 positive regulation of potassium ion transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P70604-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82995-1", "uniprot_id": [ { "id": "HS90A_RAT", "url": "https://www.uniprot.org/uniprot/P82995", "type": "external" } ], "mass": 84815.0, "length": 733, "protein_name": "Heat shock protein HSP 90-alpha", "gene_name": "Hsp90aa1", "organism": "Rat", "refseq_name": "heat shock protein HSP 90-alpha", "refseq_ac": [ { "id": "NP_786937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786937", "type": "external" } ], "gene_names_uniprotkb": "Hsp90aa1; Hsp86; Hspca", "gene_names_refseq": "Hsp86; Hsp90aa1; Hsp90; Hspca", "protein_names_uniprotkb": "Heat shock protein HSP 90-alpha; 3.6.4.10; HSP 86; HSP86; Heat shock 86 kDa", "protein_names_refseq": "HSP 86; heat shock 86 kDa; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein HSP 90-alpha", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:299331); (R-RNO-1227986); (R-RNO-1474151); (R-RNO-168928); (R-RNO-2029482); (R-RNO-203615); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-3371511); (R-RNO-3371568); (R-RNO-3371571); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-399954); (R-RNO-4420097); (R-RNO-5218920); (R-RNO-5620912); (R-RNO-5675482); (R-RNO-6798695); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-8863795); (R-RNO-8939211); (R-RNO-9009391); (R-RNO-9013418); (R-RNO-9018519); (R-RNO-9652282)", "pathway_count": 29, "publication_count": 7, "publication_id_list": "11732320;15708368;22673903;27496612;34502162;37902841;38909785", "class_list": "", "function": "HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling., [RefSeq, PubMed]; Mesenchymal stem cell-derived exosomes ameliorate hypoxic pulmonary hypertension by inhibiting the Hsp90aa1/ERK/pERK pathway., [RefSeq, PubMed]; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91XW0", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0032564 dATP binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0061684 chaperone-mediated autophagy;GO:0003009 skeletal muscle contraction;GO:0009409 response to cold;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P82995-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84076-1", "uniprot_id": [ { "id": "HPCA_RAT", "url": "https://www.uniprot.org/uniprot/P84076", "type": "external" } ], "mass": 22427.0, "length": 193, "protein_name": "Neuron-specific calcium-binding protein hippocalcin", "gene_name": "Hpca", "organism": "Rat", "refseq_name": "neuron-specific calcium-binding protein hippocalcin", "refseq_ac": [ { "id": "NP_058818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058818", "type": "external" } ], "gene_names_uniprotkb": "Hpca", "gene_names_refseq": "Hpca", "protein_names_uniprotkb": "Neuron-specific calcium-binding protein hippocalcin; P23K", "protein_names_refseq": "P23K; calcium-binding protein; neuron-specific calcium-binding protein hippocalcin", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); torsion dystonia 2 (Disease Ontology:DOID:0090038); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:29177)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1280427;15336960;1543495;23142228;29061397;31301343;8240319;8360179;8938744", "class_list": "", "function": "Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (By similarity). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (PubMed:15336960)., [UniProtKB, PubMed, UniProtKB]; Slow after hyperpolarization was identified as a downstream cellular target perturbed by a hippocalin mutation in DYT2 dystonia., [RefSeq, PubMed]; Study results suggest that significantly decreased levels of hippocalcin and parvalbumin exacerbate neuronal cell death in diabetic animals with ischemic brain injury., [RefSeq, PubMed]; These results indicate that Hpca associates with BB-CK and that together they translocate to membrane compartments in a Ca(2+)-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P32076;P41211;P70510", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0031283 negative regulation of guanylate cyclase activity;GO:1901986 response to ketamine;GO:1904010 response to Aroclor 1254;GO:0019722 calcium-mediated signaling;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P84076-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85411-1", "uniprot_id": [ { "id": "KTDAP_RAT", "url": "https://www.uniprot.org/uniprot/P85411", "type": "external" } ], "mass": 10827.0, "length": 98, "protein_name": "Keratinocyte differentiation-associated protein", "gene_name": "Krtdap", "organism": "Rat", "refseq_name": "keratinocyte differentiation-associated protein isoform X1", "refseq_ac": [ { "id": "XP_038949907", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038949907", "type": "external" } ], "gene_names_uniprotkb": "Krtdap; Kdap", "gene_names_refseq": "Kdap; Krtdap", "protein_names_uniprotkb": "Keratinocyte differentiation-associated protein", "protein_names_refseq": "keratinocyte differentiation-associated protein isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11054531", "class_list": "", "function": "May act as a soluble regulator of keratinocyte differentiation (By similarity). May play an important role in embryonic skin morphogenesis., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0042599 lamellar body;GO:0005576 extracellular region", "go_biological_process": "GO:0030154 cell differentiation;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85411-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03555-1", "uniprot_id": [ { "id": "GEPH_RAT", "url": "https://www.uniprot.org/uniprot/Q03555", "type": "external" } ], "mass": 83266.0, "length": 768, "protein_name": "Gephyrin", "gene_name": "Gphn", "organism": "Rat", "refseq_name": "gephyrin isoform 1", "refseq_ac": [ { "id": "NP_074056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074056", "type": "external" } ], "gene_names_uniprotkb": "Gphn; Gph", "gene_names_refseq": "Geph; Gphn", "protein_names_uniprotkb": "Gephyrin; Domain E; Domain G; Mo insertase; Putative glycine receptor-tubulin linker protein", "protein_names_refseq": "gephyrin isoform 1; putative glycine receptor-tubulin linker protein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); molybdenum cofactor deficiency type C (Disease Ontology:DOID:0111166); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (rno:64845); (R-RNO-947581)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10900017;11083919;11325967;12684523;1319186;15201864;16511563;22270318;22673903;23163752;25137389;25413248;25531214;27112598;29379879;29464196;30454851;34810232;8264797;9990024", "class_list": "", "function": "Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons., [RefSeq, PubMed]; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results support the view that the strength of inhibitory synapse was controlled by gephyrin palmitoylation., [RefSeq, PubMed]; Study shows that activity-dependent inhibitory synapse scaling is determined by gephyrin phosphorylation and subsequent regulation of GABAA receptor diffusion. Publication Status: Online-Only, [RefSeq, PubMed]; Study shows that the glycine receptors beta-loop sequences flanking the core-binding site differentially regulate the affinity of the receptor for gephyrin and its trapping at synapses. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.10.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.10.1.1", "type": "external" }, { "id": "2.7.7.75", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.75", "type": "external" } ], "go_molecular_function": "GO:0008940 nitrate reductase activity;GO:0061598 molybdopterin adenylyltransferase activity;GO:0061599 molybdopterin molybdotransferase activity;GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density", "go_biological_process": "GO:0072579 glycine receptor clustering;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0006605 protein targeting;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q03555-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10758-1", "uniprot_id": [ { "id": "K2C8_RAT", "url": "https://www.uniprot.org/uniprot/Q10758", "type": "external" } ], "mass": 54019.0, "length": 483, "protein_name": "Keratin, type II cytoskeletal 8", "gene_name": "Krt8", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 8", "refseq_ac": [ { "id": "NP_955402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955402", "type": "external" } ], "gene_names_uniprotkb": "Krt8; Krt2-8", "gene_names_refseq": "CYKER; Krt2-8; Krt8", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 8; CK-8; Cytokeratin endo A; Cytokeratin-8; K8; Keratin-8; Type-II keratin Kb8", "protein_names_refseq": "CK-8; K8; cytokeratin endo A; cytokeratin-8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type II cytoskeletal 8; type-II keratin Kb8", "tax_id": 10116, "disease": "liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:25626); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "1370816;15247274;16128803;16396499;1691189;18047804;22673903;22685604;34502162;36897022;38843836;41018975;7525090;8660345", "class_list": "", "function": "Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration., [RefSeq, PubMed]; Results indicate a keratins K8/K18 intermediate filament (IF) contribution to the cell stiffness-extracellular matrix (ECM) interplay through a modulation of Rho-dependent actin organization., [RefSeq, PubMed]; Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:1691189). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:15247274)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5WPB3", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0005882 intermediate filament", "go_biological_process": "GO:0060706 cell differentiation involved in embryonic placenta development;GO:0051707 response to other organism;GO:0097191 extrinsic apoptotic signaling pathway;GO:0045214 sarcomere organization;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q10758-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3BCU4-1", "uniprot_id": [ { "id": "POPD1_RAT", "url": "https://www.uniprot.org/uniprot/Q3BCU4", "type": "external" } ], "mass": 40860.0, "length": 356, "protein_name": "Popeye domain-containing protein 1", "gene_name": "Popdc1", "organism": "Rat", "refseq_name": "popeye domain-containing protein 1", "refseq_ac": [ { "id": "NP_001071058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071058", "type": "external" } ], "gene_names_uniprotkb": "Popdc1; Bves; Pop1", "gene_names_refseq": "Bves; Popdc1", "protein_names_uniprotkb": "Popeye domain-containing protein 1; Blood vessel epicardial substance; Popeye protein 1", "protein_names_refseq": "blood vessel epicardial substance; popeye domain-containing 1; popeye domain-containing protein 1; popeye protein 1", "tax_id": 10116, "disease": "autosomal recessive limb-girdle muscular dystrophy type 2X (Disease Ontology:DOID:0110290); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:365603)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12815060;17662479;22673903;24066022;27886395;33261556", "class_list": "", "function": "An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs. Publication Status: Online-Only, [RefSeq, PubMed]; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Important for skeletal muscle and heart development. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cell surface Bves/Pop1A is composed of an extracellular amino terminus, three transmembrane domains, and a cytoplasmic carboxyl terminus, which regulates cellular distribution of Bves/Pop1A during coronary vessel development., [RefSeq, PubMed]; Study demonstrated that Popdc1/Bves plays a role in the preservation of cardiomyocyte viability by affecting Rac1 activity and Bnip3 expression., [RefSeq, PubMed]; The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0030054 cell junction;GO:0005901 caveola", "go_biological_process": "GO:0060931 sinoatrial node cell development;GO:0002931 response to ischemia;GO:0007507 heart development;GO:0042391 regulation of membrane potential;GO:0043087 regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3BCU4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GFD9-1", "uniprot_id": [ { "id": "IMPCT_RAT", "url": "https://www.uniprot.org/uniprot/Q5GFD9", "type": "external" } ], "mass": 35995.0, "length": 317, "protein_name": "Protein IMPACT", "gene_name": "Impact", "organism": "Rat", "refseq_name": "protein IMPACT", "refseq_ac": [ { "id": "NP_001012235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012235", "type": "external" } ], "gene_names_uniprotkb": "Impact", "gene_names_refseq": "Impact", "protein_names_uniprotkb": "Protein IMPACT; Imprinted and ancient gene protein homolog", "protein_names_refseq": "imprinted and ancient gene protein homolog; protein IMPACT", "tax_id": 10116, "disease": "", "pathway": " (rno:497198)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15752730;22673903", "class_list": "", "function": "Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0043022 ribosome binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0045666 positive regulation of neuron differentiation;GO:0001933 negative regulation of protein phosphorylation;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5GFD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5VJ70-1", "uniprot_id": [ { "id": "IGSF5_RAT", "url": "https://www.uniprot.org/uniprot/Q5VJ70", "type": "external" } ], "mass": 40281.0, "length": 369, "protein_name": "Immunoglobulin superfamily member 5", "gene_name": "Igsf5", "organism": "Rat", "refseq_name": "immunoglobulin superfamily member 5 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001006991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006991", "type": "external" } ], "gene_names_uniprotkb": "Igsf5; Jam4", "gene_names_refseq": "Igsf5; Jam4", "protein_names_uniprotkb": "Immunoglobulin superfamily member 5; IgSF5; JAM-4; Junctional adhesion molecule 4", "protein_names_refseq": "JAM-4; cell adhesion molecule JCAM; immunoglobulin superfamily member 5 isoform 1 precursor; junctional adhesion molecule 4", "tax_id": 10116, "disease": "", "pathway": " (rno:304000)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12940823;16118391;16155592", "class_list": "", "function": "Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The subcellular localization of JAM4 was altered in puromycin aminonucleoside (PAN) nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5VJ70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIK7-1", "uniprot_id": [ { "id": "KATL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIK7", "type": "external" } ], "mass": 55201.0, "length": 488, "protein_name": "Katanin p60 ATPase-containing subunit A-like 1", "gene_name": "Katnal1", "organism": "Rat", "refseq_name": "katanin p60 ATPase-containing subunit A-like 1", "refseq_ac": [ { "id": "NP_001006957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006957", "type": "external" } ], "gene_names_uniprotkb": "Katnal1", "gene_names_refseq": "Katnal1", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A-like 1; 5.6.1.1; Katanin p60 subunit A-like 1; p60 katanin-like 1", "protein_names_refseq": "katanin p60 ATPase-containing subunit A-like 1-like; katanin p60 ATPase-containing subunit A-like 1; katanin p60 subunit A-like 1; p60 katanin-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288449)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0008352 katanin complex;GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051013 microtubule severing;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63099-1", "uniprot_id": [ { "id": "KCNB2_RAT", "url": "https://www.uniprot.org/uniprot/Q63099", "type": "external" } ], "mass": 102096.0, "length": 907, "protein_name": "Potassium voltage-gated channel subfamily B member 2", "gene_name": "Kcnb2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnb2; AC125757.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 2; CDRK; Voltage-gated potassium channel subunit Kv2.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (rno:117105); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10414301;10719893;1550672;20202934;22673903;9305895", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells (PubMed:1550672). Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:1550672, PubMed:20202934, PubMed:9305895). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20202934). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes (PubMed:9305895). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells (PubMed:1550672, PubMed:20202934)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046982 protein heterodimerization activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0072659 protein localization to plasma membrane;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63099-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642G4-1", "uniprot_id": [ { "id": "PEX14_RAT", "url": "https://www.uniprot.org/uniprot/Q642G4", "type": "external" } ], "mass": 40936.0, "length": 376, "protein_name": "Peroxisomal membrane protein PEX14", "gene_name": "Pex14", "organism": "Rat", "refseq_name": "peroxisomal membrane protein PEX14", "refseq_ac": [ { "id": "NP_742060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742060", "type": "external" } ], "gene_names_uniprotkb": "Pex14", "gene_names_refseq": "Pex14", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX14; PTS1 receptor-docking protein; Peroxin-14; Peroxisomal membrane anchor protein PEX14", "protein_names_refseq": "PTS1 receptor-docking protein; peroxin-14; peroxisomal membrane anchor protein PEX14; peroxisomal membrane protein PEX14", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 13A (Disease Ontology:DOID:0080487)", "pathway": " (rno:64460); (R-RNO-8866654); (R-RNO-9033241); (R-RNO-9603798)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10212238;12488033;19122147;22673903;30414318;32831175", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:19122147). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that PEX14 is a bona fide intrinsic membrane protein with a Nin -Cout topology, and that PEX13 adopts a Nout -Cin topology, thus exposing its carboxy-terminal Src homology 3 [SH3] domain into the organelle matrix, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2Z4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008017 microtubule binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0036250 peroxisome transport along microtubule;GO:0044721 protein import into peroxisome matrix, substrate release;GO:0007031 peroxisome organization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q642G4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR9-1", "uniprot_id": [ { "id": "EF1D_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR9", "type": "external" } ], "mass": 31330.0, "length": 281, "protein_name": "Elongation factor 1-delta", "gene_name": "Eef1d", "organism": "Rat", "refseq_name": "elongation factor 1-delta isoform 5", "refseq_ac": [ { "id": "NP_001013122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013122", "type": "external" } ], "gene_names_uniprotkb": "Eef1d", "gene_names_refseq": "Eef1d", "protein_names_uniprotkb": "Elongation factor 1-delta; EF-1-delta", "protein_names_refseq": "EF-1-delta; elongation factor 1-delta isoform 5; elongation factor 1-delta; guanine nucleotide exchange protein; translation elongation factor 1-delta subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:300033); (R-RNO-156842)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome., [UniProtKB]; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0071479 cellular response to ionizing radiation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68FR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFV3-1", "uniprot_id": [ { "id": "K1C15_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFV3", "type": "external" } ], "mass": 48870.0, "length": 447, "protein_name": "Keratin, type I cytoskeletal 15", "gene_name": "Krt15", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 15", "refseq_ac": [ { "id": "NP_001004022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004022", "type": "external" } ], "gene_names_uniprotkb": "Krt15; Ka15", "gene_names_refseq": "Ka15; Krt15", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 15; CK-15; Cytokeratin-15; K15; Keratin-15; Type I keratin Ka15", "protein_names_refseq": "CK-15; K15; cytokeratin-15; keratin 15, type I; keratin, type I cytoskeletal 15; type I keratin KA15", "tax_id": 10116, "disease": "", "pathway": " (rno:287700); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15085952;16641100;34502162;38843836;41018975", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0097110 scaffold protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005882 intermediate filament;GO:0045111 intermediate filament cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0045103 intermediate filament-based process;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IFV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7D3-1", "uniprot_id": [ { "id": "IER2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7D3", "type": "external" } ], "mass": 24596.0, "length": 221, "protein_name": "Immediate early response gene 2 protein", "gene_name": "Ier2", "organism": "Rat", "refseq_name": "immediate early response gene 2 protein", "refseq_ac": [ { "id": "NP_001009541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009541", "type": "external" } ], "gene_names_uniprotkb": "Ier2", "gene_names_refseq": "Ier2", "protein_names_uniprotkb": "Immediate early response gene 2 protein", "protein_names_refseq": "immediate early response gene 2 protein", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); childhood acute myeloid leukemia (Disease Ontology:DOID:0070323); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:494344)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17156131", "class_list": "", "function": "DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (PubMed:17156131). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048870 cell motility;GO:0071774 response to fibroblast growth factor", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M6Z5-1", "uniprot_id": [ { "id": "KIF27_RAT", "url": "https://www.uniprot.org/uniprot/Q7M6Z5", "type": "external" } ], "mass": 158880.0, "length": 1394, "protein_name": "Kinesin-like protein KIF27", "gene_name": "Kif27", "organism": "Rat", "refseq_name": "kinesin-like protein KIF27", "refseq_ac": [ { "id": "NP_932167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932167", "type": "external" } ], "gene_names_uniprotkb": "Kif27", "gene_names_refseq": "Kif27; Krp5", "protein_names_uniprotkb": "Kinesin-like protein KIF27", "protein_names_refseq": "kinesin-like protein KIF27; kinesin-related protein KIF27A; kinesin-related protein KRP5", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:246209); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12783626;22673903", "class_list": "", "function": "Plays an essential role in motile ciliogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0005871 kinesin complex", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0060271 cilium assembly;GO:0007018 microtubule-based movement;GO:0021591 ventricular system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7M6Z5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K1P8-1", "uniprot_id": [ { "id": "MOT8_RAT", "url": "https://www.uniprot.org/uniprot/Q8K1P8", "type": "external" } ], "mass": 60050.0, "length": 545, "protein_name": "Monocarboxylate transporter 8", "gene_name": "SLC16A2", "organism": "Rat", "refseq_name": "monocarboxylate transporter 8", "refseq_ac": [ { "id": "NP_671749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671749", "type": "external" } ], "gene_names_uniprotkb": "SLC16A2; Mct8", "gene_names_refseq": "Slc16a2", "protein_names_uniprotkb": "Monocarboxylate transporter 8; MCT 8; Solute carrier family 16 member 2", "protein_names_refseq": "MCT 8; monocarboxylate transporter 8; solute carrier family 16 (monocarboxylic acid transporters), member 2; solute carrier family 16, member 2 (monocarboxylic acid transporter 8); solute carrier family 16, member 2 (thyroid hormone transporter)", "tax_id": 10116, "disease": "Allan-Herndon-Dudley syndrome (Disease Ontology:DOID:0050631); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:259248); (R-RNO-879518)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12871948;18687783;21454685;22699085;24763672;25594699;26626087;31561916", "class_list": "", "function": "Cloned and identified as a very active and specific thyroid hormone transporter, [RefSeq, PubMed]; Data report here that in addition to neuronal expression, MCT8 mRNA and protein are expressed in cerebral microvessels in rats., [RefSeq, PubMed]; Differential expression and immunoreactivity of thyroid hormone transporters MCT8 and OATP1C1 in rat ovary., [RefSeq, PubMed]; Prolonged cerebral ischemia causes compensatory increase of MCT8 mRNA expression on the capillary endothelial cell membranes in the lateral ventricle of rats., [RefSeq, PubMed]; Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormone across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:12871948). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (By similarity). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (By similarity)., [UniProtKB, PubMed, UniProtKB]; The coordinated effects of Oatp1c1, Mct8, D2 and D3 in the placental barrier may regulate both transplacental TH passage and the development of trophoblast cells during thyroid dysfunction throughout the pregnancy. Publication Status: Online-Only, [RefSeq, PubMed]; The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents., [RefSeq, PubMed]; We found that dehydration induced anorexia rats showed increased number of thyrotropin-releasing hormone (TRH) cells in caudal paraventricular hypothalamic nucleus, as well as a decreased percentage of TRH-expressing neurons that co-expressed monocarboxylate transporter-8 mRNA signal., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3V9C2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015349 thyroid hormone transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006520 amino acid metabolic process;GO:0006590 thyroid hormone generation;GO:0042403 thyroid hormone metabolic process;GO:0070460 thyroid-stimulating hormone secretion;GO:2000178 negative regulation of neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8K1P8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91V33-1", "uniprot_id": [ { "id": "KHDR1_RAT", "url": "https://www.uniprot.org/uniprot/Q91V33", "type": "external" } ], "mass": 48315.0, "length": 443, "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "gene_name": "Khdrbs1", "organism": "Rat", "refseq_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "refseq_ac": [ { "id": "NP_569089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569089", "type": "external" } ], "gene_names_uniprotkb": "Khdrbs1; Sam68", "gene_names_refseq": "Khdrbs1; P62; Sam68", "protein_names_uniprotkb": "KH domain-containing, RNA-binding, signal transduction-associated protein 1; GAP-associated tyrosine phosphoprotein p62; Sam68; Src-associated in mitosis 68 kDa protein; p21 Ras GTPase-activating protein-associated p62; p68", "protein_names_refseq": "GAP-associated tyrosine phosphoprotein p62; KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1-like; KH domain-containing, RNA-binding, signal transduction-associated protein 1; p21 Ras GTPase-activating protein-associated p62; p68; src associated in mitosis, 68 kDa; src-associated in mitosis 68 kDa protein", "tax_id": 10116, "disease": "", "pathway": " (rno:117268); (R-RNO-8849468)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10437794;10748127;15345239;27105917;27236696;29393594;38843836", "class_list": "", "function": "In conclusion, miRNA-221 exerts cytoprotective effects in hypoxia-reoxygenation injury in association with alterations in autophagic cell injury. Mir-221 may constitute is a novel therapeutic target in the treatment of cardiac I/R injury., [RefSeq, PubMed]; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Sam68 might be illustrated in the apoptosis of neurons and proliferation of astrocytes after spinal cord injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0070618 Grb2-Sos complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0046831 regulation of RNA export from nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q91V33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920F3-1", "uniprot_id": [ { "id": "KHDR2_RAT", "url": "https://www.uniprot.org/uniprot/Q920F3", "type": "external" } ], "mass": 38854.0, "length": 349, "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 2", "gene_name": "Khdrbs2", "organism": "Rat", "refseq_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 2", "refseq_ac": [ { "id": "NP_579852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579852", "type": "external" } ], "gene_names_uniprotkb": "Khdrbs2; Slm1", "gene_names_refseq": "Khdrbs2; Slm1", "protein_names_uniprotkb": "KH domain-containing, RNA-binding, signal transduction-associated protein 2; SLM-1; Sam68-like mammalian protein 1; rSLM-1", "protein_names_refseq": "KH domain containing, RNA binding, signal transduction associated 2; KH domain-containing, RNA-binding, signal transduction-associated protein 2; SLM-1; Sam68-like mammalian protein 1; rSLM-1", "tax_id": 10116, "disease": "", "pathway": " (rno:170843); (R-RNO-8849468)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15345239;19282290", "class_list": "", "function": "RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis (By similarity). Binds both poly(A) and poly(U) homopolymers (By similarity). Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity)., [UniProtKB, PubMed]; SLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn)., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0042169 SH2 domain binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJV7-1", "uniprot_id": [ { "id": "KCNE3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJV7", "type": "external" } ], "mass": 12001.0, "length": 107, "protein_name": "Potassium voltage-gated channel subfamily E member 3", "gene_name": "Kcne3", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily E member 3", "refseq_ac": [ { "id": "NP_071571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071571", "type": "external" } ], "gene_names_uniprotkb": "Kcne3", "gene_names_refseq": "Kcne3; MiRP2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 3; MiRP2; MinK-related peptide 2; Minimum potassium ion channel-related peptide 2; Potassium channel subunit beta MiRP2", "protein_names_refseq": "minimum potassium ion channel-related peptide 2; mink-related peptide 2; potassium channel subunit beta MiRP2; potassium channel, voltage gated subfamily E regulatory beta subunit 3; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3; potassium voltage-gated channel subfamily E member 3; potassium voltage-gated channel, Isk-related family, member 3; potassium voltage-gated channel, Isk-related subfamily, gene 3; potassium voltage-gated channel, Isk-related subfamily, member 3", "tax_id": 10116, "disease": "Brugada syndrome 6 (Disease Ontology:DOID:0110223); hypokalemic periodic paralysis (Disease Ontology:DOID:14452)", "pathway": " (rno:63883); (R-RNO-5576890); (R-RNO-5576893)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11220365;12954870;14679187;21911611", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:12954870, PubMed:21911611). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:12954870). Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (By similarity). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (PubMed:21911611)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon;GO:0045121 membrane raft", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:1905025 negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential;GO:0030644 intracellular chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JJV7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLI4-1", "uniprot_id": [ { "id": "NCOA6_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLI4", "type": "external" } ], "mass": 45574.0, "length": 418, "protein_name": "Nuclear receptor coactivator 6", "gene_name": "Ncoa6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncoa6; Aib3; Rap250; Trbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor coactivator 6; ASC-2; Activating signal cointegrator 2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; NRC; Nuclear receptor coactivator RAP250; Nuclear receptor-activating protein, 250 kDa; PPAR-interacting protein; PRIP; Peroxisome proliferator-activated receptor-interacting protein; Thyroid hormone receptor-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116464)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10823961;10866662", "class_list": "", "function": "Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivate expression in an agonist- and AF2-dependent manner. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIH6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002793 positive regulation of peptide secretion;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JLI4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYU1-1", "uniprot_id": [ { "id": "PEX19_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYU1", "type": "external" } ], "mass": 32497.0, "length": 299, "protein_name": "Peroxisomal biogenesis factor 19", "gene_name": "LOC102548286; Pex19", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC102548286; Pex19; LOC102548286; Pex19; Pxf", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 19; Peroxin-19; Peroxisomal farnesylated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 12A (Disease Ontology:DOID:0080486); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (rno:289233); (R-RNO-1369062); (R-RNO-9603798)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036105 peroxisome membrane class-1 targeting sequence binding;GO:0033328 peroxisome membrane targeting sequence binding;GO:0051117 ATPase binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0072663 establishment of protein localization to peroxisome;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYU1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTT6-1", "uniprot_id": [ { "id": "GUAD_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTT6", "type": "external" } ], "mass": 51016.0, "length": 454, "protein_name": "Guanine deaminase", "gene_name": "Gda", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gda", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanine deaminase; 3.5.4.3; GAH; Guanase; Guanine aminase; Guanine aminohydrolase", "protein_names_refseq": "", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (R-RNO-74259)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18683930;22673903", "class_list": "", "function": "Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008892 guanine deaminase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0098794 postsynapse;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0046098 guanine metabolic process;GO:0031116 positive regulation of microtubule polymerization;GO:0006147 guanine catabolic process;GO:0006161 deoxyguanosine catabolic process;GO:0046038 GMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2T2-1", "uniprot_id": [ { "id": "KCNK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2T2", "type": "external" } ], "mass": 38228.0, "length": 336, "protein_name": "Potassium channel subfamily K member 1", "gene_name": "Kcnk1", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 1", "refseq_ac": [ { "id": "NP_067720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067720", "type": "external" } ], "gene_names_uniprotkb": "Kcnk1", "gene_names_refseq": "Kcnk1; Twik", "protein_names_uniprotkb": "Potassium channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1; Potassium channel K2P1; rTWIK", "protein_names_refseq": "inward rectifying potassium channel protein TWIK-1; potassium channel K2P1; potassium channel subfamily K member 1; potassium channel, subfamily K, member 1; potassium channel, two pore domain subfamily K, member 1; putative potassium channel TWIK; rTWIK", "tax_id": 10116, "disease": "", "pathway": " (rno:59324); (R-RNO-1299308); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "11567039;12855359;14519375;17452494;18838117;19571146;22673903;22948150;23169818;25305496;25339226;25530075;35304127;9843722", "class_list": "", "function": "Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:17452494, PubMed:19571146). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:22948150). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel. Channel activity is modulated by activation of serotonin receptors (PubMed:17452494). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G protein-coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; TASK-1 mRNA is present in ventrolateral medulla neurons that regulate respiration or circulation (C1 adrenergic neurons). TASK channels are expressed by respiratory cells with putative rhythmogenic function and by premotor and motor neurons., [RefSeq, PubMed]; TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K2p1.1 expression in primary sensory neurons of male rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005267 potassium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0034705 potassium channel complex;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035094 response to nicotine;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0014047 glutamate secretion;GO:0060075 regulation of resting membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z2T2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24090-1", "uniprot_id": [ { "id": "FETUA_RAT", "url": "https://www.uniprot.org/uniprot/P24090", "type": "external" } ], "mass": 37982.0, "length": 352, "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "Ahsg", "organism": "Rat", "refseq_name": "alpha-2-HS-glycoprotein precursor", "refseq_ac": [ { "id": "NP_037030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037030", "type": "external" } ], "gene_names_uniprotkb": "Ahsg; AABR07034632.1; Fetua", "gene_names_refseq": "Aa2-066; Ahsg; BSP; pp63", "protein_names_uniprotkb": "Alpha-2-HS-glycoprotein; 59 kDa bone sialic acid-containing protein; BSP; Fetuin-A; Glycoprotein PP63", "protein_names_refseq": "59 kDa bone sialic acid-containing protein; alpha 2 HS-glycoprotein alpha 2 (fetuin); alpha-2-HS-glycoprotein precursor; fetuin-A; glycoprotein PP63; phosphorylated N-glycoprotein pp63", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); alopecia-mental retardation syndrome 1 (Disease Ontology:DOID:0080628); gestational diabetes (Disease Ontology:DOID:11714); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25373); (R-RNO-114608); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10.1039/D0MO00044B;1370655;1371750;16641100;1707273;1849862;1860865;22673903;25986658;26828753;2766355;34106099;34680053;7681247", "class_list": "", "function": "Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells., [UniProtKB]; Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course. Publication Status: Online-Only, [RefSeq, PubMed]; Fetuin-A exerts the stimulatory effects on inflammatory responses in HUVECs, macrophage foam cell formation, and proliferation and collagen production in HASMCs, leading to the development of atherosclerosis. Erratum:[Atherosclerosis. 2016 Oct;253:346. doi: 10.1016/j.atherosclerosis.2016.05.009. PMID: 27184817], [RefSeq, PubMed]; The protective effects of pioglitazone on lipotoxicity in beta cells may involve the inhibition of the activation of the Fetuin A and TLR4 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 9641, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKD2", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0019210 kinase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0032869 cellular response to insulin stimulus;GO:0006953 acute-phase response;GO:0021987 cerebral cortex development;GO:0045780 positive regulation of bone resorption", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P24090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2J9-1", "uniprot_id": [ { "id": "RUNX2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2J9", "type": "external" } ], "mass": 24247.0, "length": 218, "protein_name": "Runt-related transcription factor 2", "gene_name": "Runx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Runx2; Cbfa1; Osf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Runt-related transcription factor 2; CBF-alpha-1; Core-binding factor subunit alpha-1; OSF-2; Osteoblast-specific transcription factor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); metabolic acidosis (Disease Ontology:DOID:0050758); glucocorticoid-induced osteoporosis (Disease Ontology:DOID:0060343); metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome (Disease Ontology:DOID:0111513); osteonecrosis (Disease Ontology:DOID:10159); osteoporosis (Disease Ontology:DOID:11476); cleidocranial dysplasia (Disease Ontology:DOID:13994); breast cancer (Disease Ontology:DOID:1612); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "28062493;40058403;9651525", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB]; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99NC7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0002051 osteoblast fate commitment;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0097187 dentinogenesis;GO:1904383 response to sodium phosphate;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2J9-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00176-1", "uniprot_id": [ { "id": "CP2B1_RAT", "url": "https://www.uniprot.org/uniprot/P00176", "type": "external" } ], "mass": 55934.0, "length": 491, "protein_name": "Cytochrome P450 2B1", "gene_name": "Cyp2b1; Cyp2b21", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp2b1; Cyp2b21; Cyp2b-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2B1; 1.14.14.1; CYPIIB1; Cytochrome P450-B; Cytochrome P450-LM2; Cytochrome P450-PB1; Cytochrome P450-PB2; Cytochrome P450b", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); stroke (Disease Ontology:DOID:0051061); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-RNO-211935); (R-RNO-211945); (R-RNO-211981); (R-RNO-211999)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "109438;19401463;2539047;2583091;2989270;6306654;6953431;8142377", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64584", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010477 response to sulfur dioxide;GO:0051592 response to calcium ion;GO:0006805 xenobiotic metabolic process;GO:0032868 response to insulin;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P00176-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88382-1", "uniprot_id": [ { "id": "MAGI2_RAT", "url": "https://www.uniprot.org/uniprot/O88382", "type": "external" } ], "mass": 141072.0, "length": 1277, "protein_name": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "gene_name": "Magi2", "organism": "Rat", "refseq_name": "membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2", "refseq_ac": [ { "id": "NP_446073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446073", "type": "external" } ], "gene_names_uniprotkb": "Magi2; Acvrinp1; Aip1; Sscam", "gene_names_refseq": "AIP-1; Acvrinp1; Acvrip1; Magi2; S-SCAM", "protein_names_uniprotkb": "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; AIP-1; Atrophin-1-interacting protein 1; MAGI-2; Membrane-associated guanylate kinase inverted 2; S-SCAM; Synaptic-scaffolding molecule", "protein_names_refseq": "activin receptor interacting protein 1; atrophin-1-interacting protein 1; membrane-associated guanylate kinase inverted 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; synaptic-scaffolding molecule", "tax_id": 10116, "disease": "nephrotic syndrome type 15 (Disease Ontology:DOID:0080271); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:113970)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10080919;10207009;10548487;10644767;12589829;15951562;15994232;16464232;16751601;17724123;22128856;22593065;22673903;23751499;9694864", "class_list": "", "function": "Chronic restraint stress influences hippocampal neuroplasticity by modulation of dendrite branching pattern and spine density paralleled by increased expression levels of synaptic scaffolding proteins., [RefSeq, PubMed]; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (PubMed:9694864). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (PubMed:17724123). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; These results suggest that S-SCAM is an essential AMPAR scaffolding molecule for the GluA2-containing pool of AMPARs, which are involved in the constitutive pathway of maintaining synaptic strength., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R271", "ec_number_list": [], "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding;GO:0046332 SMAD binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098890 extrinsic component of postsynaptic membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0010976 positive regulation of neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88382-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1Z3-1", "uniprot_id": [ { "id": "EPN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1Z3", "type": "external" } ], "mass": 62349.0, "length": 583, "protein_name": "Epsin-2", "gene_name": "Epn2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Epn2", "gene_names_refseq": "", "protein_names_uniprotkb": "Epsin-2; EPS-15-interacting protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10567358;11919637;22673903", "class_list": "", "function": "Plays a role in the formation of clathrin-coated invaginations and endocytosis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030128 clathrin coat of endocytic vesicle;GO:0098843 postsynaptic endocytic zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0030100 regulation of endocytosis;GO:0045747 positive regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54921-1", "uniprot_id": [ { "id": "EXOC2_RAT", "url": "https://www.uniprot.org/uniprot/O54921", "type": "external" } ], "mass": 104031.0, "length": 924, "protein_name": "Exocyst complex component 2", "gene_name": "Exoc2", "organism": "Rat", "refseq_name": "exocyst complex component 2", "refseq_ac": [ { "id": "NP_599241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599241", "type": "external" } ], "gene_names_uniprotkb": "Exoc2; Sec5l1; Sec5", "gene_names_refseq": "Exoc2; Rsec5; Sec5l1", "protein_names_uniprotkb": "Exocyst complex component 2; Exocyst complex component Sec5; rSec5", "protein_names_refseq": "exocyst complex component 2; exocyst complex component Sec5", "tax_id": 10116, "disease": "", "pathway": " (rno:171455); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11744922;12839989;18756269;22673903;26582389;29393594;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0090543 Flemming body;GO:0000145 exocyst", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0006904 vesicle docking involved in exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O54921-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JZQ0-1", "uniprot_id": [ { "id": "CSF1_RAT", "url": "https://www.uniprot.org/uniprot/Q8JZQ0", "type": "external" } ], "mass": 62187.0, "length": 566, "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "Csf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Csf1; Csfm", "gene_names_refseq": "", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1; CSF-1; MCSF; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); COVID-19 (Disease Ontology:DOID:0080600); osteopetrosis (Disease Ontology:DOID:13533); interstitial cystitis (Disease Ontology:DOID:13949); breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); high grade glioma (Disease Ontology:DOID:3070); systemic scleroderma (Disease Ontology:DOID:418); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); end stage renal disease (Disease Ontology:DOID:783); amyloidosis (Disease Ontology:DOID:9120); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (R-RNO-381426); (R-RNO-449836); (R-RNO-8957275); (R-RNO-9856649)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12074592;12379742;26479776", "class_list": "", "function": "Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:1990682 CSF1-CSF1R complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0030316 osteoclast differentiation;GO:0032946 positive regulation of mononuclear cell proliferation;GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0042488 positive regulation of odontogenesis of dentin-containing tooth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JZQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88339-1", "uniprot_id": [ { "id": "EPN1_RAT", "url": "https://www.uniprot.org/uniprot/O88339", "type": "external" } ], "mass": 60158.0, "length": 575, "protein_name": "Epsin-1", "gene_name": "Epn1", "organism": "Rat", "refseq_name": "epsin-1", "refseq_ac": [ { "id": "NP_476477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476477", "type": "external" } ], "gene_names_uniprotkb": "Epn1", "gene_names_refseq": "Epn1", "protein_names_uniprotkb": "Epsin-1; EPS-15-interacting protein 1", "protein_names_refseq": "EPS-15-interacting protein 1; epsin-1", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:117277); (R-RNO-182971); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10380931;10393179;10430869;10692452;10791968;10944104;11161217;11919637;12057195;12353027;22673903;25837255;32337703;9723620;9920862", "class_list": "", "function": "Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:11161217). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (PubMed:12353027, PubMed:9723620). Regulates receptor-mediated endocytosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Epsin but not AP-2 supports reconstitution of endocytic clathrin-coated vesicles., [RefSeq, PubMed]; This study finds that epsin preferentially partitions to and assembles clathrin on highly curved membrane surfaces., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0044325 transmembrane transporter binding;GO:0030276 clathrin binding;GO:0035615 clathrin adaptor activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0001701 in utero embryonic development;GO:0006897 endocytosis;GO:0007219 Notch signaling pathway;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O88339-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC0-1", "uniprot_id": [ { "id": "EFCB3_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC0", "type": "external" } ], "mass": 49804.0, "length": 432, "protein_name": "EF-hand calcium-binding domain-containing protein 3", "gene_name": "Efcab3", "organism": "Rat", "refseq_name": "EF-hand calcium-binding domain-containing protein 3", "refseq_ac": [ { "id": "NP_001013994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013994", "type": "external" } ], "gene_names_uniprotkb": "Efcab3", "gene_names_refseq": "Efcab3; RGD1305423", "protein_names_uniprotkb": "EF-hand calcium-binding domain-containing protein 3", "protein_names_refseq": "EF-hand calcium-binding domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:303589)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPN9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38650-1", "uniprot_id": [ { "id": "DYHC1_RAT", "url": "https://www.uniprot.org/uniprot/P38650", "type": "external" } ], "mass": 532252.0, "length": 4644, "protein_name": "Cytoplasmic dynein 1 heavy chain 1", "gene_name": "Dync1h1", "organism": "Rat", "refseq_name": "cytoplasmic dynein 1 heavy chain 1", "refseq_ac": [ { "id": "NP_062099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062099", "type": "external" } ], "gene_names_uniprotkb": "Dync1h1; Dhc1; Dnch1; Dnchc1; Dnec1; Dyhc; Map1c", "gene_names_refseq": "DHC1a; Dnch1; Dnchc1; Dync1h1", "protein_names_uniprotkb": "Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic; MAP 1C", "protein_names_refseq": "MAP 1C; cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; dynein heavy chain, cytosolic; dynein, cytoplasmic, heavy chain 1; microtubule-associated protein 1 C", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); childhood-onset asthma (Disease Ontology:DOID:0080815); occupational asthma (Disease Ontology:DOID:0080820); arrhythmogenic right ventricular dysplasia 13 (Disease Ontology:DOID:0110084); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:29489); (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 21, "publication_count": 9, "publication_id_list": "10893223;18683930;2140361;22673903;25670086;30978476;38843836;7684232;7690137", "class_list": "", "function": "Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functional differences between yeast and mammalian dynein are real and attributable to a C-terminal motor element absent in yeast, which resembles a 'cap' over the central pore of the mammalian dynein motor domain. Publication Status: Online-Only, [RefSeq, PubMed]; High intensity interval training (HIIT) is associated with the down-regulation of gene and protein levels of KIF5B and Dynein in the rat hippocampal tissue, although the underlying mechanisms have remained unknown. These changes suggest that HIIT may have negative effects on both the anterograde and retrograde cytoplasmic transports because the cytoplasmic transport is mediated by KIF5B and Dynein., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63178", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005938 cell cortex", "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0090235 regulation of metaphase plate congression;GO:1905832 positive regulation of spindle assembly;GO:0008090 retrograde axonal transport;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P38650-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M3L7-1", "uniprot_id": [ { "id": "EPS8_RAT", "url": "https://www.uniprot.org/uniprot/F1M3L7", "type": "external" } ], "mass": 91929.0, "length": 822, "protein_name": "Epidermal growth factor receptor kinase substrate 8", "gene_name": "Eps8", "organism": "Rat", "refseq_name": "epidermal growth factor receptor kinase substrate 8", "refseq_ac": [ { "id": "NP_001363864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363864", "type": "external" } ], "gene_names_uniprotkb": "Eps8", "gene_names_refseq": "Eps8", "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8", "protein_names_refseq": "epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 102 (Disease Ontology:DOID:0110463); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:312812)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16641100;17304222;19564905;22673903;25159326;26252776", "class_list": "", "function": "Data suggest that fascin 1 is involved in localization of actin-bundling proteins Eps8 and paladin during spermatogenesis; thus, fascin 1 regulates cytoskeletal filaments in Sertoli cells and in spermatid polarity., [RefSeq, PubMed]; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes (By similarity)., [UniProtKB]; These findings demonstrate a novel role for Wnt-Dvl1 signalling through Eps8 in the regulation of axonal remodeling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005938 cell cortex", "go_biological_process": "GO:0030832 regulation of actin filament length;GO:0070358 actin polymerization-dependent cell motility;GO:0008344 adult locomotory behavior;GO:0048149 behavioral response to ethanol;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1M3L7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08719-1", "uniprot_id": [ { "id": "EVL_RAT", "url": "https://www.uniprot.org/uniprot/O08719", "type": "external" } ], "mass": 45152.0, "length": 420, "protein_name": "Ena/VASP-like protein", "gene_name": "Evl", "organism": "Rat", "refseq_name": "ena/VASP-like protein isoform 2", "refseq_ac": [ { "id": "NP_077061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077061", "type": "external" } ], "gene_names_uniprotkb": "Evl; Rnb6", "gene_names_refseq": "Evl", "protein_names_uniprotkb": "Ena/VASP-like protein; Ena/vasodilator-stimulated phosphoprotein-like", "protein_names_refseq": "Ena-vasodilator stimulated phosphoprotein; RNB6; ena/VASP-like protein isoform 2; ena/VASP-like protein; ena/vasodilator-stimulated phosphoprotein-like", "tax_id": 10116, "disease": "tauopathy (Disease Ontology:DOID:680)", "pathway": " (rno:79115); (R-RNO-5663220)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15174098;16336193;22673903;28242260;9268706", "class_list": "", "function": "Data suggest that expression of spermiation-related genes is directly up-regulated by estrogen 17-beta-estradiol in testes of adult rats; a functional estrogen response element lies upstream of Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex, subunit 1B; Evl = enabled-VASP-like protein), [RefSeq, PubMed]; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Evl is coordinately regulated during actin remodeling in epithelial cells., [RefSeq, PubMed]; The possible link between the spectrin-based skeleton and actin via the EVL protein suggests a new way of integrating the spectrin-based skeleton in areas of dynamic actin reorganization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K217", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0030027 lamellipodium;GO:0001725 stress fiber", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:1900028 negative regulation of ruffle assembly;GO:0051289 protein homotetramerization;GO:0007417 central nervous system development;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O08719-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97677-1", "uniprot_id": [ { "id": "DLL1_RAT", "url": "https://www.uniprot.org/uniprot/P97677", "type": "external" } ], "mass": 77379.0, "length": 714, "protein_name": "Delta-like protein 1", "gene_name": "Dll1", "organism": "Rat", "refseq_name": "delta-like protein 1 precursor", "refseq_ac": [ { "id": "NP_114452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114452", "type": "external" } ], "gene_names_uniprotkb": "Dll1", "gene_names_refseq": "Dll1", "protein_names_uniprotkb": "Delta-like protein 1; Delta1; Drosophila Delta homolog 1", "protein_names_refseq": "delta-like protein 1 precursor; delta-like protein 1; delta1; drosophila Delta homolog 1", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:84010); (R-RNO-9013507)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12036964;22658936;28089369;29181775;32703409", "class_list": "", "function": "Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats., [RefSeq, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results showed that Dll1 enhanced RBL-2H3 cell degranulation and cytokine production via a novel Notch/downstream of tyrosine kinases 1 (Dok-1)/MAPKs pathway, suggesting Notch signaling was a key mediator in the effect phase of food allergy, [RefSeq, PubMed]; Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (By similarity). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerization; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:22658936). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (By similarity). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway. At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway. Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis. Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell. Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (By similarity). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation. Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression. During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression. Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium. Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels. During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression. Controls sprouting angiogenesis and subsequent vertical branch formation through regulation on tip cell differentiation. Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine. Plays a role during inner ear development; negatively regulates auditory hair cell differentiation. Plays a role during nephron development through Notch signaling pathway. Regulates growth, blood pressure and energy homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0030957 Tat protein binding;GO:0097110 scaffold protein binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0021688 cerebellar molecular layer formation;GO:0021693 cerebellar Purkinje cell layer structural organization;GO:0032693 negative regulation of interleukin-10 production;GO:0045605 negative regulation of epidermal cell differentiation;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P97677-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62824-1", "uniprot_id": [ { "id": "EXOC4_RAT", "url": "https://www.uniprot.org/uniprot/Q62824", "type": "external" } ], "mass": 110553.0, "length": 975, "protein_name": "Exocyst complex component 4", "gene_name": "Exoc4", "organism": "Rat", "refseq_name": "exocyst complex component 4", "refseq_ac": [ { "id": "NP_446327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446327", "type": "external" } ], "gene_names_uniprotkb": "Exoc4; Sec8l1; Sec8", "gene_names_refseq": "ALR; Exoc4; Sec8l1; Sec8", "protein_names_uniprotkb": "Exocyst complex component 4; Exocyst complex component Sec8; rSec8", "protein_names_refseq": "SEC8-like 1; augmenter of liver regeneration (ALR) pseudogene; exocyst complex component 4; exocyst complex component Sec8; rSec8; secretory protein SEC8", "tax_id": 10116, "disease": "", "pathway": " (rno:116654); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12675619;16181645;17827149;21658605;22673903;26582389;7568183", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Cytosolic PSD-95 interactor may function to regulate the ability of sec8 to bind to PSD-95, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0035748 myelin sheath abaxonal region;GO:0032584 growth cone membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0051223 regulation of protein transport;GO:0006612 protein targeting to membrane;GO:0007268 chemical synaptic transmission;GO:0050850 positive regulation of calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62824-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54922-1", "uniprot_id": [ { "id": "EXOC7_RAT", "url": "https://www.uniprot.org/uniprot/O54922", "type": "external" } ], "mass": 75046.0, "length": 653, "protein_name": "Exocyst complex component 7", "gene_name": "Exoc7", "organism": "Rat", "refseq_name": "exocyst complex component 7", "refseq_ac": [ { "id": "NP_073182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073182", "type": "external" } ], "gene_names_uniprotkb": "Exoc7; Exo70", "gene_names_refseq": "Exo70; Exoc7", "protein_names_uniprotkb": "Exocyst complex component 7; Exocyst complex component Exo70; rExo70", "protein_names_refseq": "exocyst complex component 7; exocyst complex component Exo70; rexo70", "tax_id": 10116, "disease": "microcephaly (Disease Ontology:DOID:10907)", "pathway": " (rno:64632); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "17086175;17761530;19155211;22673903;22748316;24223996;28536622;30374940;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity). It is required for neuron survival and plays an essential role in cortical development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exo70 in vascular smooth muscle cell migration. Exo70 and alpha-actin were co-localized at the leading edge of migrating cells. Publication Status: Online-Only, [RefSeq, PubMed]; Exo70 is essentially involved in the formation of synapses and neuronal dendritic morphology., [RefSeq, PubMed]; Exo70, in addition to functioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and membrane traffic during cell migration., [RefSeq, PubMed]; Exo70-phosphatidylinositol 4,5-bisphosphate interaction is critical for the docking and fusion of post-Golgi secretory vesicles, but not for their transport to the plasma membrane, [RefSeq, PubMed]; Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a kinetic activator of the Arp2/3 complex that promotes actin filament nucleation and branching, [RefSeq, PubMed]; Fusion of GLUT4 vesicles is the rate-limiting step regulated by insulin downstream of Exo70-mediated tethering, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005829 cytosol;GO:0098794 postsynapse;GO:0005815 microtubule organizing center;GO:0030496 midbody", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0051963 regulation of synapse assembly;GO:0006887 exocytosis;GO:0071806 protein transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O54922-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05197-1", "uniprot_id": [ { "id": "EF2_RAT", "url": "https://www.uniprot.org/uniprot/P05197", "type": "external" } ], "mass": 95284.0, "length": 858, "protein_name": "Elongation factor 2", "gene_name": "Eef2", "organism": "Rat", "refseq_name": "elongation factor 2", "refseq_ac": [ { "id": "NP_058941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058941", "type": "external" } ], "gene_names_uniprotkb": "Eef2", "gene_names_refseq": "Eef2; Ef-2", "protein_names_uniprotkb": "Elongation factor 2; 3.6.5.-; EF-2", "protein_names_refseq": "elongation factor 2", "tax_id": 10116, "disease": "spinocerebellar ataxia 26 (Disease Ontology:DOID:0050975); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); glaucoma (Disease Ontology:DOID:1686); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon adenocarcinoma (Disease Ontology:DOID:234); brain glioblastoma multiforme (Disease Ontology:DOID:3073); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29565); (R-RNO-156902); (R-RNO-5358493); (R-RNO-6798695); (R-RNO-8876725)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "18047804;22673903;2721670;28726101;3014523;30826070;30987676;32926469;34502162;3693353;41549750;4368673", "class_list": "", "function": "A reduction in eEF2, an increase in miR-143-5p, and activation of AMPK signaling was observed in degenerative disc degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Eukaryotic elongation factor 2 kinase activation in M. soleus under 14-day hindlimb unloading of rats, [RefSeq, PubMed]; Results show that oxytocin (OXT) recruits several intracellular signaling cascades to induce protein synthesis, which mediates the anxiolytic effects of OXT within the paraventricular nucleus of the hypothalamus and suggests that eukaryotic elongation factor 2 represents a novel target for anxiety-related disorders., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97619", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.1.1.314", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314", "type": "external" }, { "id": "6.3.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.14", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0002931 response to ischemia;GO:0003009 skeletal muscle contraction;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05197-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07756-1", "uniprot_id": [ { "id": "CPSM_RAT", "url": "https://www.uniprot.org/uniprot/P07756", "type": "external" } ], "mass": 164580.0, "length": 1500, "protein_name": "Carbamoyl-phosphate synthase [ammonia], mitochondrial", "gene_name": "Cps1", "organism": "Rat", "refseq_name": "carbamoyl-phosphate synthase [ammonia], mitochondrial precursor", "refseq_ac": [ { "id": "NP_058768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058768", "type": "external" } ], "gene_names_uniprotkb": "Cps1", "gene_names_refseq": "Cps1; cps-1; cps", "protein_names_uniprotkb": "Carbamoyl-phosphate synthase [ammonia], mitochondrial; 6.3.4.16; CPSase I; Carbamoyl-phosphate synthetase I", "protein_names_refseq": "CPSase I; carbamoyl-phosphate synthase [ammonia], mitochondrial precursor; carbamoyl-phosphate synthase [ammonia], mitochondrial; carbamoyl-phosphate synthetase 1, mitochondrial; carbamoyl-phosphate synthetase I; carbamyl phosphate synthetase I; carbamyl-phosphate synthetase; carboamyl-phosphate synthetase 1", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); cataract 42 (Disease Ontology:DOID:0110237); hypertension (Disease Ontology:DOID:10763); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); vascular disease (Disease Ontology:DOID:178); hepatocellular carcinoma (Disease Ontology:DOID:684); carbamoyl phosphate synthetase I deficiency disease (Disease Ontology:DOID:9280); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:497840); (R-RNO-70635)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "19754428;22673903;23649895;24098488;25684186;2991241;3038878;38843836", "class_list": "", "function": "Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell., [UniProtKB]; The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.16", "type": "external" }, { "id": "2.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.2", "type": "external" }, { "id": "3.5.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.3", "type": "external" }, { "id": "6.3.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.5", "type": "external" }, { "id": "3.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004087 carbamoyl-phosphate synthase (ammonia) activity;GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004175 endopeptidase activity;GO:0005524 ATP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0055081 monoatomic anion homeostasis;GO:0070409 carbamoyl phosphate biosynthetic process;GO:0071400 cellular response to oleic acid;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P07756-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21674-1", "uniprot_id": [ { "id": "FST_RAT", "url": "https://www.uniprot.org/uniprot/P21674", "type": "external" } ], "mass": 37838.0, "length": 344, "protein_name": "Follistatin", "gene_name": "Fst", "organism": "Rat", "refseq_name": "follistatin precursor", "refseq_ac": [ { "id": "NP_036693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036693", "type": "external" } ], "gene_names_uniprotkb": "Fst", "gene_names_refseq": "FOL1; FS; Fst-288; Fst; RATFOL1", "protein_names_uniprotkb": "Follistatin; Activin-binding protein; FS", "protein_names_refseq": "activin-binding protein; follistatin precursor; follistatin-A", "tax_id": 10116, "disease": "restrictive dermopathy (Disease Ontology:DOID:0060762); polycystic ovary syndrome (Disease Ontology:DOID:11612)", "pathway": " (rno:24373); (R-RNO-2473224)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12867435;16482217;2725528;28277126;29113826;32014555;36899937;8472873", "class_list": "", "function": "Follistatin expression in the central nervous system of the adult rat., [RefSeq, PubMed]; Manifestation of polycystic ovarian syndrome-like phenotype following prenatal exposure to excess androgen is associated with irregularity in expression of the FST gene during the estrus cycle, [RefSeq, PubMed]; Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These data suggest that ghrelin inhibits myocardial fibrosis, attenuates left ventricular remodeling, and eventually improves cardiac function by adjusting Act A/FS imbalance., [RefSeq, PubMed]; Tubule-Derived Follistatin Is Increased in the Urine of Rats with Renal Ischemia and Reflects the Severity of Acute Tubular Damage. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80XW7", "ec_number_list": [], "go_molecular_function": "GO:0038102 activin receptor antagonist activity;GO:0043395 heparan sulfate proteoglycan binding;GO:0048185 activin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046882 negative regulation of follicle-stimulating hormone secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21674-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32738-1", "uniprot_id": [ { "id": "CLAT_RAT", "url": "https://www.uniprot.org/uniprot/P32738", "type": "external" } ], "mass": 71864.0, "length": 640, "protein_name": "Choline O-acetyltransferase", "gene_name": "Chat", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chat", "gene_names_refseq": "", "protein_names_uniprotkb": "Choline O-acetyltransferase; 2.3.1.6; CHOACTase; ChAT; Choline acetylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital myasthenic syndrome 6 (Disease Ontology:DOID:0110671); Alzheimer's disease (Disease Ontology:DOID:10652); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (rno:290567); (R-RNO-1483191); (R-RNO-264642)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15131697;15477102;2160042;22673903;7493935;8479291", "class_list": "", "function": "Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63849;Q64342", "ec_number_list": [ { "id": "2.3.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.6", "type": "external" } ], "go_molecular_function": "GO:0004102 choline O-acetyltransferase activity;GO:0033265 choline binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0001547 antral ovarian follicle growth;GO:0007529 establishment of synaptic specificity at neuromuscular junction;GO:0007274 neuromuscular synaptic transmission;GO:0007584 response to nutrient;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32738-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61203-1", "uniprot_id": [ { "id": "CSN2_RAT", "url": "https://www.uniprot.org/uniprot/P61203", "type": "external" } ], "mass": 51597.0, "length": 443, "protein_name": "COP9 signalosome complex subunit 2", "gene_name": "Cops2", "organism": "Rat", "refseq_name": "COP9 signalosome complex subunit 2 isoform 1", "refseq_ac": [ { "id": "NP_695209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695209", "type": "external" } ], "gene_names_uniprotkb": "Cops2; Csn2; Trip15", "gene_names_refseq": "CSN2; Cops2; Trip15", "protein_names_uniprotkb": "COP9 signalosome complex subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; SGN2; Signalosome subunit 2; TR-interacting protein 15; TRIP-15; Thyroid receptor-interacting protein 15", "protein_names_refseq": "COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 signalosome complex subunit 2 isoform 1; COP9 signalosome complex subunit 2; JAB1-containing signalosome subunit 2; SGN2; TR-interacting protein 15; TRIP-15; alien homolog; signalosome subunit 2; thyroid receptor-interacting protein 15; tyroid receptor interacting protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:261736); (R-RNO-5696394); (R-RNO-6781823); (R-RNO-8856825); (R-RNO-8951664); (R-RNO-9013422)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "12522100;12524175;12606288;32408015", "class_list": "", "function": "Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1., [UniProtKB, PubMed, UniProtKB]; Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN., [RefSeq, PubMed]; Expressed at an early stage of neuronal differentiaation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P731", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0008283 cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P61203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70531-1", "uniprot_id": [ { "id": "EF2K_RAT", "url": "https://www.uniprot.org/uniprot/P70531", "type": "external" } ], "mass": 81489.0, "length": 724, "protein_name": "Eukaryotic elongation factor 2 kinase", "gene_name": "Eef2k", "organism": "Rat", "refseq_name": "eukaryotic elongation factor 2 kinase", "refseq_ac": [ { "id": "NP_037079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037079", "type": "external" } ], "gene_names_uniprotkb": "Eef2k", "gene_names_refseq": "Eef2k; SMEF2K", "protein_names_uniprotkb": "Eukaryotic elongation factor 2 kinase; 2.7.11.20; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K", "protein_names_refseq": "calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; eEF-2 kinase; eEF-2K; elongation factor 2 kinase; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor 2 kinase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); otitis media (Disease Ontology:DOID:10754); nephrotic syndrome (Disease Ontology:DOID:1184); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (rno:25435); (R-RNO-166208)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "11171059;17957382;18683930;22673903;30737648;32569665;33191388;35598844;8514778;8663182;9144159", "class_list": "", "function": "Age-dependent increase in activity of eukaryotic elongation factor 2 kinase in mesenteric arteries from spontaneously hypertensive rats., [RefSeq, PubMed]; EEF2K/eEF2 axis under GD condition mediates the inhibition of apoptotic H9c2 cell death., [RefSeq, PubMed]; Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits perivascular sympathetic nerve stimulation-induced vasoconstriction in isolated renal artery., [RefSeq, PubMed]; NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase., [RefSeq, PubMed]; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09089", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.20", "type": "external" } ], "go_molecular_function": "GO:0004686 elongation factor-2 kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043197 dendritic spine", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:1990637 response to prolactin;GO:0002931 response to ischemia;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P70531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08877-1", "uniprot_id": [ { "id": "DYN3_RAT", "url": "https://www.uniprot.org/uniprot/Q08877", "type": "external" } ], "mass": 97914.0, "length": 869, "protein_name": "Dynamin-3", "gene_name": "Dnm3", "organism": "Rat", "refseq_name": "dynamin-3 isoform 1", "refseq_ac": [ { "id": "NP_612547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612547", "type": "external" } ], "gene_names_uniprotkb": "Dnm3; Dyn3", "gene_names_refseq": "Dnm3; dynamin-2", "protein_names_uniprotkb": "Dynamin-3; 3.6.5.5; Dynamin, testicular; T-dynamin", "protein_names_refseq": "T-dynamin; dynamin, testicular; dynamin-3 isoform 1; testicular dynamin", "tax_id": 10116, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:171574); (R-RNO-166016); (R-RNO-2132295); (R-RNO-437239); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "17376771;22673903;23410488;23687302;8360266;8752097;9725914", "class_list": "", "function": "DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic death of cardiomyocyte., [RefSeq, PubMed]; Dynamin isoforms select appropriate vesicle reuse pathways associated with specific neuronal firing patterns, [RefSeq, PubMed]; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QXL9", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0031798 type 1 metabotropic glutamate receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098844 postsynaptic endocytic zone membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0046847 filopodium assembly;GO:0007416 synapse assembly;GO:0051491 positive regulation of filopodium assembly;GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08877-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJL0-1", "uniprot_id": [ { "id": "ERMIN_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJL0", "type": "external" } ], "mass": 32228.0, "length": 282, "protein_name": "Ermin", "gene_name": "Ermn", "organism": "Rat", "refseq_name": "ermin", "refseq_ac": [ { "id": "NP_001008312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008312", "type": "external" } ], "gene_names_uniprotkb": "Ermn", "gene_names_refseq": "Ermn; RGD1308367; juxtanodin", "protein_names_uniprotkb": "Ermin; JN; Juxtanodin", "protein_names_refseq": "JN; ermin, ERM-like protein; ermin", "tax_id": 10116, "disease": "", "pathway": " (rno:295619)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16051705;19332107;20610382;21221725;22673903;23198089", "class_list": "", "function": "Data indicate that juxtanodin is non-globular and monomeric in solution., [RefSeq, PubMed]; Juxtanodin is an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking., [RefSeq, PubMed]; Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes., [RefSeq, PubMed]; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)., [UniProtKB, PubMed]; Specific phosphorylation of JN might serve as an important mechanism regulating JN functions., [RefSeq, PubMed]; These results identify JN as a marker protein for OE sustentacular cells, and support the glia-like nature of OE sustentacular cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031344 regulation of cell projection organization;GO:0007015 actin filament organization;GO:0008360 regulation of cell shape;GO:0001763 morphogenesis of a branching structure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5RJL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIK6-1", "uniprot_id": [ { "id": "DAAF8_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIK6", "type": "external" } ], "mass": 52998.0, "length": 481, "protein_name": "Dynein axonemal assembly factor 8", "gene_name": "Dnaaf8", "organism": "Rat", "refseq_name": "dynein axonemal assembly factor 8", "refseq_ac": [ { "id": "NP_001014137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014137", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf8; Daap1", "gene_names_refseq": "Daap1; Dnaaf8", "protein_names_uniprotkb": "Dynein axonemal assembly factor 8; Dynein axonemal-associated protein 1; Uncharacterized protein C16orf71 homolog", "protein_names_refseq": "dynein axonemal assembly factor 8; dynein axonemal-associated protein 1; uncharacterized protein C16orf71 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360479)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN5-1", "uniprot_id": [ { "id": "F228A_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN5", "type": "external" } ], "mass": 35195.0, "length": 306, "protein_name": "Protein FAM228A", "gene_name": "Fam228a", "organism": "Rat", "refseq_name": "protein FAM228A", "refseq_ac": [ { "id": "NP_001014096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014096", "type": "external" } ], "gene_names_uniprotkb": "Fam228a", "gene_names_refseq": "Fam228a", "protein_names_uniprotkb": "Protein FAM228A", "protein_names_refseq": "UPF0638 protein C2orf84 homolog; protein FAM228A", "tax_id": 10116, "disease": "", "pathway": " (rno:313936)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63618-1", "uniprot_id": [ { "id": "ESPN_RAT", "url": "https://www.uniprot.org/uniprot/Q63618", "type": "external" } ], "mass": 90569.0, "length": 837, "protein_name": "Espin", "gene_name": "Espn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Espn", "gene_names_refseq": "", "protein_names_uniprotkb": "Espin; Ectoplasmic specialization protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 36 (Disease Ontology:DOID:0110494)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "12598619;15190118;22673903;8799813;9763424", "class_list": "", "function": "Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells (PubMed:9763424). Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6GYS2;Q6GYS3;Q80ZB6;Q80ZB7;Q80ZB8;Q80ZB9;Q9Z2B4", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0043197 dendritic spine;GO:0031941 filamentous actin", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0051494 negative regulation of cytoskeleton organization;GO:0007015 actin filament organization;GO:0007626 locomotory behavior;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63618-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63768-1", "uniprot_id": [ { "id": "CRK_RAT", "url": "https://www.uniprot.org/uniprot/Q63768", "type": "external" } ], "mass": 33845.0, "length": 304, "protein_name": "Adapter molecule crk", "gene_name": "Crk", "organism": "Rat", "refseq_name": "adapter molecule crk", "refseq_ac": [ { "id": "NP_062175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062175", "type": "external" } ], "gene_names_uniprotkb": "Crk; Crko", "gene_names_refseq": "CrkII; Crko; Crk", "protein_names_uniprotkb": "Adapter molecule crk; Proto-oncogene c-Crk; p38", "protein_names_refseq": "adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; p38; proto-oncogene C-crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog", "tax_id": 10116, "disease": "degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:54245); (R-RNO-170984); (R-RNO-186763); (R-RNO-2029482); (R-RNO-372708); (R-RNO-4420097); (R-RNO-8849471); (R-RNO-8875555); (R-RNO-8875656); (R-RNO-912631)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "12198159;22673903;24480980;8901553", "class_list": "", "function": "Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1., [UniProtKB, UniProtKB]; Overexpression of miR-126 significantly inhibited the activation and migration of hepatic stellate cell through targeting CRK. Erratum:[Cell Physiol Biochem. 2014;33(3):882], [RefSeq, PubMed]; Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016020 membrane", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0035728 response to hepatocyte growth factor;GO:0061847 response to cholecystokinin;GO:1990859 cellular response to endothelin;GO:0098749 cerebellar neuron development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63768-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYN3-1", "uniprot_id": [ { "id": "CJ062_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYN3", "type": "external" } ], "mass": 34024.0, "length": 305, "protein_name": "Uncharacterized protein C10orf62 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C10orf62 homolog", "refseq_ac": [ { "id": "NP_001037746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037746", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C1h10orf62", "protein_names_uniprotkb": "Uncharacterized protein C10orf62 homolog", "protein_names_refseq": "uncharacterized protein C10orf62 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:682010)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYQ8-1", "uniprot_id": [ { "id": "FAHD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYQ8", "type": "external" } ], "mass": 24480.0, "length": 221, "protein_name": "Oxaloacetate tautomerase FAHD1, mitochondrial", "gene_name": "Fahd1", "organism": "Rat", "refseq_name": "oxaloacetate tautomerase FAHD1, mitochondrial", "refseq_ac": [ { "id": "NP_001020162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020162", "type": "external" } ], "gene_names_uniprotkb": "Fahd1", "gene_names_refseq": "Fahd1; RGD1304560", "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD1, mitochondrial; 3.7.1.5; 4.1.1.112; 5.3.2.2; Acylpyruvase FAHD1; Fumarylacetoacetate hydrolase domain-containing protein 1; OAA decarboxylase; Oxaloacetate decarboxylase", "protein_names_refseq": "OAA decarboxylase; acylpyruvase FAHD1, mitochondrial; fumarylacetoacetate hydrolase domain-containing protein 1; oxaloacetate decarboxylase, mitochondrial; oxaloacetate decarboxylase; oxaloacetate tautomerase FAHD1, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:302980); (R-RNO-70268)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "3.7.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" } ], "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0018773 acetylpyruvate hydrolase activity;GO:0034545 fumarylpyruvate hydrolase activity;GO:0047621 acylpyruvate hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0C9-1", "uniprot_id": [ { "id": "SGMR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0C9", "type": "external" } ], "mass": 25270.0, "length": 223, "protein_name": "Sigma non-opioid intracellular receptor 1", "gene_name": "Sigmar1", "organism": "Rat", "refseq_name": "sigma non-opioid intracellular receptor 1", "refseq_ac": [ { "id": "NP_112258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112258", "type": "external" } ], "gene_names_uniprotkb": "Sigmar1; Oprs1", "gene_names_refseq": "Oprs1; Sigmar1", "protein_names_uniprotkb": "Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R", "protein_names_refseq": "opioid receptor, sigma 1; sigma 1-type opioid receptor; sigma non-opioid intracellular receptor 1; sigma1-receptor; sigma1R", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); amyotrophic lateral sclerosis type 16 (Disease Ontology:DOID:0060207); autosomal recessive distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111065); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:29336)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10771347;11149946;11687279;11861817;11988171;12535781;15064136;15170821;15466698;16522641;36707178;37922065;38141412;39138590;9489711", "class_list": "", "function": "Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress., [RefSeq, PubMed]; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain., [RefSeq, PubMed]; Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells., [RefSeq, PubMed]; Sigma-1 receptor is involved in modification of ER-mitochondria proximity and Ca[2+] homeostasis in cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1J7;Q9Z2W2", "ec_number_list": [], "go_molecular_function": "GO:0004985 G protein-coupled opioid receptor activity;GO:0042802 identical protein binding;GO:0031852 mu-type opioid receptor binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0097305 response to alcohol;GO:0006869 lipid transport;GO:0007399 nervous system development;GO:0043524 negative regulation of neuron apoptotic process;GO:0070207 protein homotrimerization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9R0C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV48-1", "uniprot_id": [ { "id": "SHAN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV48", "type": "external" } ], "mass": 226335.0, "length": 2167, "protein_name": "SH3 and multiple ankyrin repeat domains protein 1", "gene_name": "Shank1", "organism": "Rat", "refseq_name": "SH3 and multiple ankyrin repeat domains protein 1", "refseq_ac": [ { "id": "NP_113939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113939", "type": "external" } ], "gene_names_uniprotkb": "Shank1", "gene_names_refseq": "Shank1a; Shank1; Spank1; Sstrip", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 1; GKAP/SAPAP-interacting protein; SPANK-1; SSTR-interacting protein; SSTRIP; Shank1; Somatostatin receptor-interacting protein; Synamon", "protein_names_refseq": "GKAP/SAPAP-interacting protein; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SPANK-1; SSTR-interacting protein; somatostatin receptor-interacting protein; synamon", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:78957); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10433268;10433269;10488079;10506216;10551867;10806096;10958799;11178875;11498055;11509555;12954649;15340156;18287537;19345194;22645316;22673903;25775468;28263956;29250591;32564287;33577886;38843836", "class_list": "", "function": "Correlation of distinct behaviors to the modified expression of cerebral Shank1,3 and BDNF in two autistic animal models., [RefSeq, PubMed]; Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients., [RefSeq, PubMed]; Loss of scaffold proteins via knockdown of Shank1 or Shank2, but not Shank3, led to a reduction of the number but not the unitary response of AMPAR-containing synapses. Only when both Shank1 and Shank2 were knocked down, were both the number and the unitary response of active synapses reduced. This reduction was accompanied by a decrease in NMDAR-mediated synaptic response. Erratum:[eNeuro. 2018 Mar 19;5(1):ENEURO.0073-18.2018. doi: 10.1523/ENEURO.0073-18.2018. PMID: 29569864] Publication Status: Online-Only, [RefSeq, PubMed]; SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane., [RefSeq, PubMed]; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function., [UniProtKB, PubMed, PubMed]; Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZZ8;Q9WU13;Q9WUE8", "ec_number_list": [], "go_molecular_function": "GO:0031877 somatostatin receptor binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0001664 G protein-coupled receptor binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0046959 habituation;GO:0050894 determination of affect;GO:0008306 associative learning;GO:0030534 adult behavior", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9WV48-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVB9-1", "uniprot_id": [ { "id": "DVL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVB9", "type": "external" } ], "mass": 75447.0, "length": 695, "protein_name": "Segment polarity protein dishevelled homolog DVL-1", "gene_name": "Dvl1", "organism": "Rat", "refseq_name": "segment polarity protein dishevelled homolog DVL-1", "refseq_ac": [ { "id": "NP_114008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114008", "type": "external" } ], "gene_names_uniprotkb": "Dvl1", "gene_names_refseq": "Dvl1; dvl-1", "protein_names_uniprotkb": "Segment polarity protein dishevelled homolog DVL-1; DSH homolog 1; Dishevelled-1", "protein_names_refseq": "DSH homolog 1; dishevelled, dsh homolog 1; dishevelled-1; segment polarity protein dishevelled homolog DVL-1", "tax_id": 10116, "disease": "autosomal dominant Robinow syndrome 2 (Disease Ontology:DOID:0060765); DiGeorge syndrome (Disease Ontology:DOID:11198); neurodegenerative disease (Disease Ontology:DOID:1289); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:83721); (R-RNO-201688); (R-RNO-4086400); (R-RNO-4641258); (R-RNO-4641262); (R-RNO-5663220)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11113207;11354832;22673903;26400647;29510185;32105766;36726071", "class_list": "", "function": "Dishevelled-1 regulated apoptosis through NF-kappaB in cerebral ischemia/reperfusion injury in rats., [RefSeq, PubMed]; Hyperoxia exposure upregulates Dvl-1 and activates Wnt/beta-catenin signaling pathway in newborn rat lung. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity)., [UniProtKB]; Results indicate that Wnt5a-mediated JNK3 activation participates in Ischemia/Reperfusion brain injury by targeting the Dvl-1-beta-arrestin2/JNK3 interaction, [RefSeq, PubMed]; The interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUG5;Q9WVB8", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0099054 presynapse assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WVB9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYD3-1", "uniprot_id": [ { "id": "PA2G4_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYD3", "type": "external" } ], "mass": 43657.0, "length": 394, "protein_name": "Proliferation-associated protein 2G4", "gene_name": "Pa2g4", "organism": "Rat", "refseq_name": "proliferation-associated protein 2G4", "refseq_ac": [ { "id": "NP_001004206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004206", "type": "external" } ], "gene_names_uniprotkb": "Pa2g4", "gene_names_refseq": "Ebp1; Pa2g4", "protein_names_uniprotkb": "Proliferation-associated protein 2G4", "protein_names_refseq": "ErbB3-binding protein 1; proliferation-associated 2G4, 38kDa; proliferation-associated protein 2G4", "tax_id": 10116, "disease": "", "pathway": " (rno:288778); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "16642037;16832058;17316401;22673903;24878627", "class_list": "", "function": "Ebp1 might regulate cell survival and differentiation through two distinctive p48 and p42 isoforms., [RefSeq, PubMed]; Ebp1 was upregulated in Schwann cells following sciatic nerve crush., [RefSeq, PubMed]; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; PKC-delta antagonizes apoptosis through phosphorylating Ebp1 and protects it from apoptotic degradation., [RefSeq, PubMed]; Results suggest that Ebp1 contributes to inhibition of DNA fragmentation by caspase-activated DNase, and that nuclear Akt might contribute to suppressing apoptosis through interaction with Ebp1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006417 regulation of translation;GO:0043066 negative regulation of apoptotic process;GO:0045892 negative regulation of DNA-templated transcription;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AYD3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A208-1", "uniprot_id": [ { "id": "SRGP2_RAT", "url": "https://www.uniprot.org/uniprot/D4A208", "type": "external" } ], "mass": 120878.0, "length": 1071, "protein_name": "SLIT-ROBO Rho GTPase-activating protein 2", "gene_name": "Srgap2", "organism": "Rat", "refseq_name": "SLIT-ROBO Rho GTPase-activating protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001388305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388305", "type": "external" } ], "gene_names_uniprotkb": "Srgap2", "gene_names_refseq": "RGD1566016; Srgap2", "protein_names_uniprotkb": "SLIT-ROBO Rho GTPase-activating protein 2; srGAP2", "protein_names_refseq": "SLIT-ROBO Rho GTPase-activating protein 2 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360840); (R-RNO-5663220); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013406); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "17710530;22673903;27748913;29393594;30685845", "class_list": "", "function": "Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia., [UniProtKB, UniProtKB]; Results suggest that srGAPs are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions., [RefSeq, PubMed]; The translocation of srGAP2 in the cytoplasm and cell nucleus in different cell types may function as a director in decisions regarding cell fate., [RefSeq, PubMed]; These data provide new insights into the specific regulation of the |-Srgap2-Fam72a-| master gene., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0003363 lamellipodium assembly involved in ameboidal cell migration;GO:1904861 excitatory synapse assembly;GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D4A208-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ0-1", "uniprot_id": [ { "id": "RUFY3_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ0", "type": "external" } ], "mass": 52907.0, "length": 469, "protein_name": "Protein RUFY3", "gene_name": "Rufy3", "organism": "Rat", "refseq_name": "protein RUFY3 isoform 4", "refseq_ac": [ { "id": "NP_001020298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020298", "type": "external" } ], "gene_names_uniprotkb": "Rufy3; Ripx", "gene_names_refseq": "Ripx; Rufy3; Singar1", "protein_names_uniprotkb": "Protein RUFY3; RIPx; RUN and FYVE domain-containing protein 3; Rap2-interacting protein x; Singar; Single axon-regulated protein", "protein_names_refseq": "RUN and FYVE domain-containing protein 3; protein RUFY3 isoform 4; protein RUFY3; rap2-interacting protein x; singar2; single axon-regulated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:360921)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17439943;18683930;22673903", "class_list": "", "function": "ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Plays a role in the generation of neuronal polarity formation and axon growth (PubMed:17439943). Implicated in the formation of a single axon by developing neurons (PubMed:17439943). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (PubMed:17439943). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5HLX7;A5JUR6", "ec_number_list": [], "go_molecular_function": "GO:0034452 dynactin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5FVJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MZ67-1", "uniprot_id": [ { "id": "SHOT1_RAT", "url": "https://www.uniprot.org/uniprot/A0MZ67", "type": "external" } ], "mass": 71446.0, "length": 633, "protein_name": "Shootin-1", "gene_name": "Shtn1", "organism": "Rat", "refseq_name": "shootin-1 isoform 1", "refseq_ac": [ { "id": "NP_001073173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073173", "type": "external" } ], "gene_names_uniprotkb": "Shtn1; RGD1311558", "gene_names_refseq": "RGD1311558; Shootin1; Shtn1", "protein_names_uniprotkb": "Shootin-1; Shootin1", "protein_names_refseq": "shootin-1 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292139)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17030985;17439943;18519736;20664640;22673903;23408951;23453953;26261183;27177867", "class_list": "", "function": "Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:17030985, PubMed:17439943, PubMed:18519736, PubMed:20664640). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth (PubMed:18519736, PubMed:23453953). Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone (PubMed:17030985). Also plays a role in regenerative neurite outgrowth (PubMed:20664640). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth, [RefSeq, PubMed]; Shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization., [RefSeq, PubMed]; Shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. A chemoattractant, netrin-1, positively regulates traction forces at axonal growth cones via Pak1-mediated shootin1 phosphorylation., [RefSeq, PubMed]; The shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth., [RefSeq, PubMed]; These results suggest that shootin1b may function in various peripheral tissues including epithelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0MZ64", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0050839 cell adhesion molecule binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0060327 cytoplasmic actin-based contraction involved in cell motility;GO:0061163 endoplasmic reticulum polarization;GO:0061573 actin filament bundle retrograde transport;GO:0007409 axonogenesis;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A0MZ67-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13589-1", "uniprot_id": [ { "id": "PACA_RAT", "url": "https://www.uniprot.org/uniprot/P13589", "type": "external" } ], "mass": 19557.0, "length": 175, "protein_name": "Pituitary adenylate cyclase-activating polypeptide", "gene_name": "Adcyap1", "organism": "Rat", "refseq_name": "pituitary adenylate cyclase-activating polypeptide precursor", "refseq_ac": [ { "id": "NP_058685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058685", "type": "external" } ], "gene_names_uniprotkb": "Adcyap1", "gene_names_refseq": "Adcyap1; Pacap", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide; PACAP; PRP-48", "protein_names_refseq": "adenylate cyclase activating polypeptide 1 (pituitary); pituitary adenylate cyclase activating polypeptide 1; pituitary adenylate cyclase-activating polypeptide precursor (Pacap); pituitary adenylate cyclase-activating polypeptide precursor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); renal hypomagnesemia 3 (Disease Ontology:DOID:0060880); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hypertension (Disease Ontology:DOID:10763); cystitis (Disease Ontology:DOID:1679); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (rno:24166); (R-RNO-420092)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "18198219;2268329;23800469;2803320;36842389;37511603;37646964;37775045;37880634;7835287", "class_list": "", "function": "Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury., [RefSeq, PubMed]; PACAP inhibition alleviates neuropathic pain by modulating Nav1.7 through the MAPK/ERK signaling pathway in a rat model of chronic constriction injury., [RefSeq, PubMed]; PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (PubMed:23800469). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (PubMed:18198219). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy., [RefSeq, PubMed]; Unveiling adcyap1 as a protective factor linking pain and nerve regeneration through single-cell RNA sequencing of rat dorsal root ganglion neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016521 pituitary adenylate cyclase activating polypeptide activity;GO:0031858 pituitary adenylate cyclase-activating polypeptide receptor binding;GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0043005 neuron projection", "go_biological_process": "GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus;GO:0090274 positive regulation of somatostatin secretion;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFN2-1", "uniprot_id": [ { "id": "SAHH2_RAT", "url": "https://www.uniprot.org/uniprot/B5DFN2", "type": "external" } ], "mass": 53753.0, "length": 483, "protein_name": "S-adenosylhomocysteine hydrolase-like protein 1", "gene_name": "Ahcyl1", "organism": "Rat", "refseq_name": "S-adenosylhomocysteine hydrolase-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001102031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102031", "type": "external" } ], "gene_names_uniprotkb": "Ahcyl1; Irbit", "gene_names_refseq": "Ahcyl1; IRBIT", "protein_names_uniprotkb": "S-adenosylhomocysteine hydrolase-like protein 1; AdoHcyase 2; IP3R-binding protein released with inositol 1,4,5-trisphosphate; Putative adenosylhomocysteinase 2; S-adenosyl-L-homocysteine hydrolase 2", "protein_names_refseq": "IP3R-binding protein released with inositol 1,4,5-trisphosphate; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1 isoform 1; S-adenosylhomocysteine hydrolase-like protein 1; adoHcyase 2; putative adenosylhomocysteinase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362013); (R-RNO-5578775)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20584908;26439876;26509711;35562179", "class_list": "", "function": "IRBIT forms signaling complexes with PIPKIalpha and NBCe1-B, whose activity is regulated by PI(4,5)P2. Publication Status: Online-Only, [RefSeq, PubMed]; IRBIT is critically involved in mediating activation of NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases II-dependent pathway., [RefSeq, PubMed]; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (By similarity). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (By similarity). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (By similarity). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition. May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state. Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (By similarity). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). Functions as a SAH (S-adenosyl-L-homocysteine) sensor that inhibits autophagy through an MTORC1-independent mechanism. Upon SAH binding, interacts with the catalytic domain of PIK3C3, inhibiting its lipid kinase activity and reducing production of phosphatidylinositol-3-phosphate (PtdIns3P), thereby blocking autophagosome formation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1. Publication Status: Online-Only, [RefSeq, PubMed]; The present study documents that IRBIT is expressed in Leydig and Sertoli cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A5X8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0051592 response to calcium ion;GO:0006915 apoptotic process;GO:0038166 angiotensin-activated signaling pathway;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B5DFN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63755-1", "uniprot_id": [ { "id": "PRDM2_RAT", "url": "https://www.uniprot.org/uniprot/Q63755", "type": "external" } ], "mass": 187555.0, "length": 1706, "protein_name": "PR domain zinc finger protein 2", "gene_name": "Prdm2", "organism": "Rat", "refseq_name": "PR domain zinc finger protein 2", "refseq_ac": [ { "id": "NP_001071116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071116", "type": "external" } ], "gene_names_uniprotkb": "Prdm2; Riz", "gene_names_refseq": "Prdm2; Riz", "protein_names_uniprotkb": "PR domain zinc finger protein 2; 2.1.1.355; PR domain-containing protein 2; Retinoblastoma protein-interacting zinc finger protein; Zinc finger protein RIZ", "protein_names_refseq": "PR domain 2; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; retinoblastoma interacting zinc finger protein; retinoblastoma protein-binding zinc finger protein; retinoblastoma protein-interacting zinc finger protein; zinc finger protein RIZ", "tax_id": 10116, "disease": "", "pathway": " (rno:313678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;27573876;7538672", "class_list": "", "function": "Findings indicate that PRDM2-mediated reprogramming of the genome in neurons of the dorsomedial prefrontal cortex is involved in increasing alcohol self-administration, compulsive-like drinking and stress-induced relapse. This broad spectrum of actions provides a strong rationale to explore PRMD2 itself or some of its downstream targets as candidate targets for novel alcoholism medications., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032355 response to estradiol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63755-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920Q3-1", "uniprot_id": [ { "id": "SPT19_RAT", "url": "https://www.uniprot.org/uniprot/Q920Q3", "type": "external" } ], "mass": 18041.0, "length": 154, "protein_name": "Spermatogenesis-associated protein 19, mitochondrial", "gene_name": "Spata19", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 19, mitochondrial precursor", "refseq_ac": [ { "id": "NP_599211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599211", "type": "external" } ], "gene_names_uniprotkb": "Spata19; Spas1; Spergen1", "gene_names_refseq": "Spas1; Spata19; spergen-1", "protein_names_uniprotkb": "Spermatogenesis-associated protein 19, mitochondrial; Spergen-1; Spermatogenic cell-specific gene 1 protein", "protein_names_refseq": "spermatogenesis-associated protein 19, mitochondrial precursor; spermatogenesis-associated protein 19, mitochondrial; spermatogenic cell-specific gene 1 protein; spermatogenic specific-gene1", "tax_id": 10116, "disease": "", "pathway": " (rno:171403)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11967211;22673903;29393594", "class_list": "", "function": "Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23441-1", "uniprot_id": [ { "id": "NKX21_RAT", "url": "https://www.uniprot.org/uniprot/P23441", "type": "external" } ], "mass": 38554.0, "length": 372, "protein_name": "Homeobox protein Nkx-2.1", "gene_name": "Nkx2-1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nkx2-1; Nkx-2.1; Titf1; Ttf-1; Ttf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Nkx-2.1; TTF-1; Thyroid nuclear factor 1; Thyroid transcription factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "choreatic disease (Disease Ontology:DOID:12859); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (rno:25628)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1976511;22356123;22673903;7980615;8282100;8898894;9430685", "class_list": "", "function": "Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08630;O70121", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0030878 thyroid gland development;GO:0021879 forebrain neuron differentiation;GO:0021877 forebrain neuron fate commitment;GO:0031128 developmental induction;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P23441-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX74-1", "uniprot_id": [ { "id": "SHAN2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX74", "type": "external" } ], "mass": 158684.0, "length": 1474, "protein_name": "SH3 and multiple ankyrin repeat domains protein 2", "gene_name": "Shank2", "organism": "Rat", "refseq_name": "SH3 and multiple ankyrin repeat domains protein 2 isoform b", "refseq_ac": [ { "id": "NP_001004133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004133", "type": "external" } ], "gene_names_uniprotkb": "Shank2; Cortbp1", "gene_names_refseq": "CortBP1; ProSAP1; Shank2E; Shank2; Spank-3", "protein_names_uniprotkb": "SH3 and multiple ankyrin repeat domains protein 2; CortBP1; Cortactin-binding protein 1; GKAP/SAPAP-interacting protein; ProSAP1; Proline-rich synapse-associated protein 1; SPANK-3; Shank2", "protein_names_refseq": "GKAP/SAPAP-interacting protein; SH3 and multiple ankyrin repeat domains protein 2 isoform b; SH3 and multiple ankyrin repeat domains protein 2-like; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; cortactin-binding protein 1; proline-rich synapse-associated protein 1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:171093)", "pathway_count": 1, "publication_count": 20, "publication_id_list": "10414979;10506216;10527873;10806096;10958799;10964907;14679199;14977424;15014124;15632121;16293618;16758162;17244609;17304222;18683930;22673903;29250591;32564287;37574039;9742101", "class_list": "", "function": "Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients., [RefSeq, PubMed]; Loss of scaffold proteins via knockdown of Shank1 or Shank2, but not Shank3, led to a reduction of the number but not the unitary response of AMPAR-containing synapses. Only when both Shank1 and Shank2 were knocked down, were both the number and the unitary response of active synapses reduced. This reduction was accompanied by a decrease in NMDAR-mediated synaptic response. Erratum:[eNeuro. 2018 Mar 19;5(1):ENEURO.0073-18.2018. doi: 10.1523/ENEURO.0073-18.2018. PMID: 29569864] Publication Status: Online-Only, [RefSeq, PubMed]; Remote ischemic conditioning alleviates chronic cerebral hypoperfusion-induced cognitive decline and synaptic dysfunction via the miR-218a-5p/SHANK2 pathway., [RefSeq, PubMed]; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O70470;Q6WB19;Q9QX93;Q9QZZ9;Q9WUV9;Q9WUW0;Q9WV46", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0035255 ionotropic glutamate receptor binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007584 response to nutrient;GO:0007612 learning;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q9QX74-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04961-1", "uniprot_id": [ { "id": "PCNA_RAT", "url": "https://www.uniprot.org/uniprot/P04961", "type": "external" } ], "mass": 28749.0, "length": 261, "protein_name": "DNA sliding clamp PCNA", "gene_name": "Pcna", "organism": "Rat", "refseq_name": "DNA sliding clamp PCNA", "refseq_ac": [ { "id": "NP_071776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071776", "type": "external" } ], "gene_names_uniprotkb": "Pcna", "gene_names_refseq": "PCNAR; Pcna/cyclin; Pcna", "protein_names_uniprotkb": "DNA sliding clamp PCNA; Cyclin; PCNA; Proliferating cell nuclear antigen", "protein_names_refseq": "DNA sliding clamp PCNA; cyclin", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); mucositis (Disease Ontology:DOID:0080178); ataxia-telangiectasia-like disorder 2 (Disease Ontology:DOID:0081385); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); osteoporosis (Disease Ontology:DOID:11476); Lewy body dementia (Disease Ontology:DOID:12217); leiomyoma (Disease Ontology:DOID:127); obstructive jaundice (Disease Ontology:DOID:13603); hypothyroidism (Disease Ontology:DOID:1459); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); invasive ductal carcinoma (Disease Ontology:DOID:3008); liver cancer (Disease Ontology:DOID:3571); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:25737); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-174411); (R-RNO-174414); (R-RNO-174417); (R-RNO-174437); (R-RNO-4615885); (R-RNO-5358565); (R-RNO-5651801); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6804114); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183); (R-RNO-8866654)", "pathway_count": 25, "publication_count": 7, "publication_id_list": "15982757;2884104;29333769;29393594;29569173;29748930;33510839", "class_list": "", "function": "Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion., [UniProtKB, UniProtKB]; D-Limonene Alleviates Acute Kidney Injury Following Gentamicin Administration in Rats: Role of NF-kappaB Pathway, Mitochondrial Apoptosis, Oxidative Stress, and PCNA. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that the positive expression of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen (Ki-67) is related to the fluoride-induced spermatogenesis dysfunction in the testis., [RefSeq, PubMed]; Explored the expression and significance of proliferating cell nuclear antigen (PCNA) and P53 in regenerating rat atrophy parotid gland from the gene and protein levels., [RefSeq, PubMed]; The damaged retinal pigment epithelium showed earlier expression of PCNA and RPE65 than photoreceptor out segments, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0032139 dinucleotide insertion or deletion binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0070557 PCNA-p21 complex;GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006287 base-excision repair, gap-filling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P04961-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05714-1", "uniprot_id": [ { "id": "RAB4A_RAT", "url": "https://www.uniprot.org/uniprot/P05714", "type": "external" } ], "mass": 24409.0, "length": 218, "protein_name": "Ras-related protein Rab-4A", "gene_name": "Rab4a", "organism": "Rat", "refseq_name": "ras-related protein Rab-4A", "refseq_ac": [ { "id": "NP_037151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037151", "type": "external" } ], "gene_names_uniprotkb": "Rab4a; Rab4", "gene_names_refseq": "Rab4a; Rab4", "protein_names_uniprotkb": "Ras-related protein Rab-4A; 3.6.5.2", "protein_names_refseq": "Ras-related small GTP binding protein 4; ras-related protein Rab-4A", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); factor XI deficiency (Disease Ontology:DOID:2229); Noonan syndrome (Disease Ontology:DOID:3490)", "pathway": " (rno:25532); (R-RNO-1660499); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8875656)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "20098723;22980744;26254426;28818525;3344209", "class_list": "", "function": "Our results suggest that spinal SGK1 phosphorylation, which subsequently triggers the GRASP-1/Rab4 cascade, plays a pivotal role in CFA-induced inflammatory pain by regulating GluR1-containing AMPAR recycling in the dorsal horn., [RefSeq, PubMed]; Rab4a is involved in the regulation of endocytosis and protein trafficking in cells, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4A is involved in protein transport. Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study shows for the first time that neovascularization within the pulmonary vasculature is dependent on the prorecycling endocytic proteins Rab4 and p18., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6U4", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05714-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07379-1", "uniprot_id": [ { "id": "PCKGC_RAT", "url": "https://www.uniprot.org/uniprot/P07379", "type": "external" } ], "mass": 69416.0, "length": 622, "protein_name": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "gene_name": "Pck1", "organism": "Rat", "refseq_name": "phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "refseq_ac": [ { "id": "NP_942075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942075", "type": "external" } ], "gene_names_uniprotkb": "Pck1", "gene_names_refseq": "GTP; PCK; PEPCK-C; Pck1; Pepck; RATPEPCK", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; 2.7.11.-; 4.1.1.32; PEPCK-C; Serine-protein kinase PCK1", "protein_names_refseq": "phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; serine-protein kinase PCK1", "tax_id": 10116, "disease": "MEHMO syndrome (Disease Ontology:DOID:0060801); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); leukodystrophy (Disease Ontology:DOID:10579); Alzheimer's disease (Disease Ontology:DOID:10652); glucose metabolism disease (Disease Ontology:DOID:4194); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypopituitarism (Disease Ontology:DOID:9406)", "pathway": " (rno:362282); (R-RNO-70263)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "17685635;18197707;18335579;18772387;20476774;22673903;23127136;24863970;26322521;26709450;28345895;2909519;2993287;30193097;31180589;31461616;32036699;35462799;4186849;6096365", "class_list": "", "function": "Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Cytosolic phosphoenolpyruvate carboxykinase is expressed in alpha-cells from human and murine pancreas., [RefSeq, PubMed]; Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:26322521, PubMed:26709450, PubMed:28345895, PubMed:30193097, PubMed:31461616, PubMed:4186849). Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097). At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097). At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097). Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity). The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity). In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (By similarity). The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The relationship between PEPCK metabolism in the urinary tract and insulin resistance and diabetes is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0030145 manganese ion binding;GO:0031406 carboxylic acid binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0046327 glycerol biosynthetic process from pyruvate;GO:0051365 cellular response to potassium ion starvation;GO:0097403 cellular response to raffinose;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P07379-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07632-1", "uniprot_id": [ { "id": "SODC_RAT", "url": "https://www.uniprot.org/uniprot/P07632", "type": "external" } ], "mass": 15912.0, "length": 154, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "Sod1", "organism": "Rat", "refseq_name": "superoxide dismutase [Cu-Zn]", "refseq_ac": [ { "id": "NP_058746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058746", "type": "external" } ], "gene_names_uniprotkb": "Sod1", "gene_names_refseq": "CuZnSOD; Sod1", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1; 1.8.-.-; Hydrogen sulfide oxidase", "protein_names_refseq": "hydrogen sulfide oxidase; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); dry eye syndrome (Disease Ontology:DOID:10140); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); Behcet's disease (Disease Ontology:DOID:13241); low tension glaucoma (Disease Ontology:DOID:13544); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); renal artery obstruction (Disease Ontology:DOID:2972); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); nutritional deficiency disease (Disease Ontology:DOID:5113); myocardial infarction (Disease Ontology:DOID:5844); prion disease (Disease Ontology:DOID:649); progressive supranuclear palsy (Disease Ontology:DOID:678); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); cutaneous leishmaniasis (Disease Ontology:DOID:9111); ocular hypertension (Disease Ontology:DOID:9282); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24786); (R-RNO-114608); (R-RNO-3299685)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "1379810;22673903;23064900;2703531;35022040;35307768;3595611;35998476;3628012;3790250;38834681;8224914;8837775", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mechanism underlying the targeted regulation of the SOD1 3'UTR by the AUF1/Dicer1/miR-155/SOD1 pathway in sodium arsenite-induced liver injury., [RefSeq, PubMed]; Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine. Publication Status: Online-Only, [RefSeq, PubMed]; Regulatory mechanism of downregulation of SOD1 expression on cardiomyocyte function., [RefSeq, PubMed]; Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2/HO-1 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0034465 response to carbon monoxide;GO:0008090 retrograde axonal transport;GO:0000303 response to superoxide;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P07632-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08753-1", "uniprot_id": [ { "id": "GNAI3_RAT", "url": "https://www.uniprot.org/uniprot/P08753", "type": "external" } ], "mass": 40522.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-3", "gene_name": "Gnai3; Gpr61", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-3", "refseq_ac": [ { "id": "NP_037238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037238", "type": "external" } ], "gene_names_uniprotkb": "Gnai3; Gpr61; Gnai-3", "gene_names_refseq": "GIP3A; Gnai3", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-3; G(i) alpha-3", "protein_names_refseq": "Guanine nucleotide binding, protein, alpha inhibiting polypeptide 3; g(i) alpha-3; guanine nucleotide binding protein (G protein), alpha inhibiting 3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; guanine nucleotide binding protein, alpha inhibiting 3; guanine nucleotide-binding protein G(i) subunit alpha-3; guanine nucleotide-binding protein G(i) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); subcortical band heterotopia (Disease Ontology:DOID:0111169); X-linked lissencephaly 1 (Disease Ontology:DOID:0112239); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); McCune Albright syndrome (Disease Ontology:DOID:1858); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); dyslexia (Disease Ontology:DOID:4428); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25643); (rno:310780); (R-RNO-170670); (R-RNO-392170); (R-RNO-418594); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "11121039;11387333;16870394;19211784;20462955;2159473;21653697;25187647;27072656;2820999;2834384;28692698;31363053", "class_list": "", "function": "Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:2159473). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). Stimulates the activity of receptor-regulated K(+) channels (By similarity). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (By similarity). The active GTP-bound form activates the calcium permeant TRPC5 ion channels (By similarity)., [UniProtKB, PubMed, UniProtKB]; Nitric oxide decreased the enhanced expression of Gialpha-2/3 proteins and hyperproliferation of Vascular smooth muscle cells from spontaneously hypertensive rats by cGMP-independent mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization. May be involved in the regulation of food intake and body weight., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0042588 zymogen granule;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0032930 positive regulation of superoxide anion generation;GO:0051301 cell division;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0033864 positive regulation of NAD(P)H oxidase activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P08753-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17955-1", "uniprot_id": [ { "id": "NUP62_RAT", "url": "https://www.uniprot.org/uniprot/P17955", "type": "external" } ], "mass": 53397.0, "length": 525, "protein_name": "Nuclear pore glycoprotein p62", "gene_name": "Nup62", "organism": "Rat", "refseq_name": "nuclear pore glycoprotein p62", "refseq_ac": [ { "id": "NP_075586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075586", "type": "external" } ], "gene_names_uniprotkb": "Nup62", "gene_names_refseq": "Np62; Nup62", "protein_names_uniprotkb": "Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62", "protein_names_refseq": "62 kDa nucleoporin; nuclear pore glycoprotein 62; nuclear pore glycoprotein p62; nucleoporin Nup62", "tax_id": 10116, "disease": "primary biliary cholangitis (Disease Ontology:DOID:12236); striatonigral degeneration (Disease Ontology:DOID:4751)", "pathway": " (rno:65274); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 17, "publication_id_list": "10375398;16188232;2050692;20657584;2190987;22311971;22673903;25349423;26025361;28406021;28951553;3200844;3313397;37802024;7849028;8707840;9721187", "class_list": "", "function": "Complexes of Nup62 suggest the crucial role of the coiled-coil motifs in providing plasticity to various modular assemblies, [RefSeq, PubMed]; Essential component of the nuclear pore complex (PubMed:2190987, PubMed:8707840). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuclear breakdown (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress, [RefSeq, PubMed]; S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy., [RefSeq, PubMed]; We carried out solution analysis utilizing the entire ordered regions of Nup62, Nup54, and Nup58, and demonstrate that they form a dynamic 'triple complex', [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2VCW0", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0051425 PTB domain binding;GO:0044877 protein-containing complex binding;GO:0042169 SH2 domain binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0046601 positive regulation of centriole replication;GO:0046580 negative regulation of Ras protein signal transduction;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0007166 cell surface receptor signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P17955-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22057-1", "uniprot_id": [ { "id": "PTGDS_RAT", "url": "https://www.uniprot.org/uniprot/P22057", "type": "external" } ], "mass": 21301.0, "length": 189, "protein_name": "Prostaglandin-H2 D-isomerase", "gene_name": "Ptgds", "organism": "Rat", "refseq_name": "prostaglandin-H2 D-isomerase precursor", "refseq_ac": [ { "id": "NP_037147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037147", "type": "external" } ], "gene_names_uniprotkb": "Ptgds", "gene_names_refseq": "PH2DISO; Ptgds", "protein_names_uniprotkb": "Prostaglandin-H2 D-isomerase; 5.3.99.2; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS2; PGDS; Prostaglandin-D2 synthase", "protein_names_refseq": "PGD2 synthase; PGDS2; PGDS; Prostaglandin D synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; prostaglandin D2 synthase (brain); prostaglandin-H2 D-isomerase precursor; prostaglandin-H2 D-isomerase", "tax_id": 10116, "disease": "XFE progeroid syndrome (Disease Ontology:DOID:0060590); cerebrooculofacioskeletal syndrome 4 (Disease Ontology:DOID:0080914); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); kidney failure (Disease Ontology:DOID:1074); hypertension (Disease Ontology:DOID:10763); nephrosclerosis (Disease Ontology:DOID:11664); azoospermia (Disease Ontology:DOID:14227); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); carotid artery disease (Disease Ontology:DOID:3407); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myelofibrosis (Disease Ontology:DOID:4971); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25526); (R-RNO-2162123)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10387044;10650953;11058225;11565799;12488457;1608945;1723819;2642896;28025147;29287795;31708494;7836410;8216319;8415655;8599604;8815894;9188476;9430563;9582446;9746734", "class_list": "", "function": "Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10387044, PubMed:10650953, PubMed:11058225, PubMed:9188476). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; ER-depletion lowering the 'hypothalamus-uterus-kidney' axis functions by perturbing the renal ERbeta/Ptgds signalling pathway., [RefSeq, PubMed]; HIF-1alpha-l-PGDS-PPARgamma regulates hypoxia-induced ANP secretion in beating rat atria, [RefSeq, PubMed]; Lipocalin-type prostaglandin synthase (L-PGDS) may have a role in sleep and chronic intermittent hypoxia, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0004667 prostaglandin-D synthase activity;GO:0005504 fatty acid binding;GO:0005501 retinoid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0051384 response to glucocorticoid;GO:0019371 cyclooxygenase pathway;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P22057-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63014-1", "uniprot_id": [ { "id": "PRRX1_RAT", "url": "https://www.uniprot.org/uniprot/P63014", "type": "external" } ], "mass": 27269.0, "length": 245, "protein_name": "Paired mesoderm homeobox protein 1", "gene_name": "Prrx1", "organism": "Rat", "refseq_name": "paired mesoderm homeobox protein 1", "refseq_ac": [ { "id": "NP_722543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722543", "type": "external" } ], "gene_names_uniprotkb": "Prrx1", "gene_names_refseq": "Pmx1; Prrx1; Prx-1", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 1; PRX-1; Paired-related homeobox protein 1; rHox", "protein_names_refseq": "paired mesoderm homeobox 1; paired mesoderm homeobox protein 1; paired-related homeobox protein 1; rHox", "tax_id": 10116, "disease": "agnathia-otocephaly complex (Disease Ontology:DOID:0060341)", "pathway": " (rno:266813)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22673903;25795141;27660222;27665494;28737764;31545082;8749718", "class_list": "", "function": "Expression of Prx1 and Tcf4 is decreased in the developing diaphragm in the nitrofen-induced congenital diaphragmatic hernia in Sprague- Dawley rats animal model., [RefSeq, PubMed]; Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm., [UniProtKB, UniProtKB]; Overexpression of prrx1 can successfully induce sinus node-like cells., [RefSeq, PubMed]; PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are present at the periphery of the embryonic pituitary and participate in pituitary vasculogenesis by differentiation into vascular endothelial cells and pericytes., [RefSeq, PubMed]; Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis induced by silica., [RefSeq, PubMed]; Studied and identified Prrx1 as a novel valuable target in liver fibrosis. Prxx1 was found to have a major role in PDGF-induced migration and chemotaxis., [RefSeq, PubMed]; Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain., [UniProtKB, UniProtKB]; Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P43271;Q02810;Q643W9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0070570 regulation of neuron projection regeneration;GO:0045880 positive regulation of smoothened signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63014-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70582-1", "uniprot_id": [ { "id": "NUP54_RAT", "url": "https://www.uniprot.org/uniprot/P70582", "type": "external" } ], "mass": 55745.0, "length": 510, "protein_name": "Nuclear pore complex protein Nup54", "gene_name": "Nup54", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup54 isoform 2", "refseq_ac": [ { "id": "NP_059057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059057", "type": "external" } ], "gene_names_uniprotkb": "Nup54", "gene_names_refseq": "Nup54", "protein_names_uniprotkb": "Nuclear pore complex protein Nup54; 54 kDa nucleoporin; Nucleoporin Nup54", "protein_names_refseq": "54 kDa nucleoporin; nuclear pore complex protein Nup54 isoform 2; nuclear pore complex protein Nup54; nucleoporin Nup54; nucleoporin p54", "tax_id": 10116, "disease": "dystonia 37, early-onset with striatal lesions (Disease Ontology:DOID:0060956)", "pathway": " (rno:53372); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 6, "publication_id_list": "22036567;24574455;26025361;34502162;38843836;8707840", "class_list": "", "function": "A 1:1:1 stoichiometry of the Nup62 complex, where Nup54 is central with direct binding to Nup62 and Nup58., [RefSeq, PubMed]; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study reports the crystal structures of the Nup54-Nup58 and Nup62-Nup54 interacting domains and reconstruct the molecular architecture of the NPC transport channel., [RefSeq, PubMed]; We carried out solution analysis utilizing the entire ordered regions of Nup62, Nup54, and Nup58, and demonstrate that they form a dynamic 'triple complex', [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0032991 protein-containing complex;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0006605 protein targeting;GO:0051028 mRNA transport;GO:0042306 regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70582-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7B4-1", "uniprot_id": [ { "id": "PRCA1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7B4", "type": "external" } ], "mass": 35333.0, "length": 311, "protein_name": "Protein PROCA1", "gene_name": "Proca1", "organism": "Rat", "refseq_name": "protein PROCA1", "refseq_ac": [ { "id": "NP_001020929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020929", "type": "external" } ], "gene_names_uniprotkb": "Proca1", "gene_names_refseq": "Proca1", "protein_names_uniprotkb": "Protein PROCA1", "protein_names_refseq": "protein PROCA1", "tax_id": 10116, "disease": "", "pathway": " (rno:497959)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0050482 arachidonate secretion;GO:0007005 mitochondrion organization;GO:0035694 mitochondrial protein catabolic process;GO:0006644 phospholipid metabolic process;GO:0141164 mitochondrial protein quality control", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7B4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0L4-1", "uniprot_id": [ { "id": "NUBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0L4", "type": "external" } ], "mass": 34045.0, "length": 320, "protein_name": "Cytosolic Fe-S cluster assembly factor NUBP1", "gene_name": "Nubp1", "organism": "Rat", "refseq_name": "cytosolic Fe-S cluster assembly factor NUBP1", "refseq_ac": [ { "id": "NP_001009619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009619", "type": "external" } ], "gene_names_uniprotkb": "Nubp1; NUBP1", "gene_names_refseq": "Nubp1", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor NUBP1; NBP 1; Nucleotide-binding protein 1", "protein_names_refseq": "NBP 1; cytosolic Fe-S cluster assembly factor NUBP1; nucleotide binding protein 1 (MinD homolog, E. coli); nucleotide-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287042)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005814 centriole;GO:0005930 axoneme;GO:1990229 iron-sulfur cluster assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0072697 protein localization to cell cortex;GO:0006879 intracellular iron ion homeostasis;GO:0001558 regulation of cell growth;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0L4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63488-1", "uniprot_id": [ { "id": "S20A2_RAT", "url": "https://www.uniprot.org/uniprot/Q63488", "type": "external" } ], "mass": 70748.0, "length": 656, "protein_name": "Sodium-dependent phosphate transporter 2", "gene_name": "Slc20a2", "organism": "Rat", "refseq_name": "sodium-dependent phosphate transporter 2", "refseq_ac": [ { "id": "NP_058919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058919", "type": "external" } ], "gene_names_uniprotkb": "Slc20a2; Pit2; Ram1", "gene_names_refseq": "Ab1-188; Glvr2; Pit-2; RAM-1; Ram1; Slc20a2", "protein_names_uniprotkb": "Sodium-dependent phosphate transporter 2; Phosphate transporter 2; PiT-2; RAM-1; Receptor for amphotropic viruses 1; Solute carrier family 20 member 2", "protein_names_refseq": "gibbon ape leukemia virus receptor 2; phosphate transporter 2; receptor for amphitropic viruses 1; receptor for amphotropic viruses 1; sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2", "tax_id": 10116, "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230)", "pathway": " (rno:29502); (R-RNO-427652)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14584042;15564340;17322102;19073637;19493963;19841935;20526720;21454685;22673903;8041748;8278411", "class_list": "", "function": "Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency., [RefSeq, PubMed]; Expression in renal brush border reduced by parathyroid hormone, [RefSeq, PubMed]; MRNA expression level of Glvr-2 was increased by the addition of inorganic phosphate (Pi) in bone marrow stromal cells, [RefSeq, PubMed]; PiT-1 (Slc20a1) and PiT-2 (Slc20a2) were detected at the basolateral membrane of hepatocytes., [RefSeq, PubMed]; Results describe the regulation of the sodium/phosphate cotransporters SCL34A3 and SLC20A2 during phosphate deprivation and acidosis in rat kidney., [RefSeq, PubMed]; Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:19073637, PubMed:8041748). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; We have used RNA interference to demonstrate that Pit1 and Pit2 are the transporters responsible for Na-dependent Pi transport in VSMCs., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0030501 positive regulation of bone mineralization;GO:0035435 phosphate ion transmembrane transport;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63488-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63638-1", "uniprot_id": [ { "id": "SPEG_RAT", "url": "https://www.uniprot.org/uniprot/Q63638", "type": "external" } ], "mass": 354166.0, "length": 3259, "protein_name": "Striated muscle-specific serine/threonine-protein kinase", "gene_name": "Speg", "organism": "Rat", "refseq_name": "striated muscle-specific serine/threonine-protein kinase isoform 1", "refseq_ac": [ { "id": "NP_001102272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102272", "type": "external" } ], "gene_names_uniprotkb": "Speg; Apeg1", "gene_names_refseq": "APEG-1; Apeg1; Speg", "protein_names_uniprotkb": "Striated muscle-specific serine/threonine-protein kinase; 2.7.11.1; APEG-1; Aortic preferentially expressed protein 1", "protein_names_refseq": "SPEG complex locus; aortic preferentially expressed gene 1; aortic preferentially expressed protein 1; striated muscle-specific serine/threonine-protein kinase isoform 1; striated muscle-specific serine/threonine-protein kinase", "tax_id": 10116, "disease": "centronuclear myopathy 5 (Disease Ontology:DOID:0111222)", "pathway": " (rno:363256)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;31790338;8663449", "class_list": "", "function": "Isoform 2 may have a role in regulating the growth and differentiation of arterial smooth muscle cells., [UniProtKB]; Striated muscle-specific serine/threonine-protein kinase beta segregates with high versus low responsiveness to endurance exercise training., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 39, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072359 circulatory system development;GO:0001701 in utero embryonic development;GO:0055013 cardiac muscle cell development;GO:0042692 muscle cell differentiation;GO:0060541 respiratory system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63638-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812D1-1", "uniprot_id": [ { "id": "PSIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q812D1", "type": "external" } ], "mass": 59639.0, "length": 528, "protein_name": "PC4 and SFRS1-interacting protein", "gene_name": "Psip1", "organism": "Rat", "refseq_name": "PC4 and SFRS1-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_786941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786941", "type": "external" } ], "gene_names_uniprotkb": "Psip1; Ledgf", "gene_names_refseq": "Ledgf; Psip1; Psip2; SBP75", "protein_names_uniprotkb": "PC4 and SFRS1-interacting protein; Lens epithelium-derived growth factor", "protein_names_refseq": "PC4 and SFRS1 interacting protein 1; PC4 and SFRS1 interacting protein 2; PC4 and SFRS1-interacting protein isoform 1; PC4 and SFRS1-interacting protein; lens epithelium-derived growth factor; supercoiled DNA binding protein 75", "tax_id": 10116, "disease": "", "pathway": " (rno:313323); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNY0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0097100 supercoiled DNA binding;GO:0140297 DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0034399 nuclear periphery;GO:0000792 heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q812D1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H7-1", "uniprot_id": [ { "id": "TRAK2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H7", "type": "external" } ], "mass": 101639.0, "length": 913, "protein_name": "Trafficking kinesin-binding protein 2", "gene_name": "Trak2", "organism": "Rat", "refseq_name": "trafficking kinesin-binding protein 2", "refseq_ac": [ { "id": "NP_598244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598244", "type": "external" } ], "gene_names_uniprotkb": "Trak2; Als2cr3; Grif1; Oip98", "gene_names_refseq": "Als2cr3; GRIF-1; Trak2", "protein_names_uniprotkb": "Trafficking kinesin-binding protein 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog; GABA-A receptor-interacting factor 1; GRIF-1; O-GlcNAc transferase-interacting protein of 98 kDa", "protein_names_refseq": "GABA-A receptor interacting factor-1; O-GlcNAc transferase-interacting protein of 98 kDa; amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog; trafficking kinesin-binding protein 2; trafficking protein, kinesin binding 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 68 (Disease Ontology:DOID:0112204); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:171086); (R-RNO-9013419)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12034717;12435728;17062640;19528298", "class_list": "", "function": "GRIF1 may participate in microtubule-based transport of early endosomes by acting as an adaptor linking Hrs-containing endosomes to kinesin., [RefSeq, PubMed]; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8R2H6;Q8R4G3", "ec_number_list": [], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0017022 myosin binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006493 protein O-linked glycosylation;GO:0006605 protein targeting;GO:0008333 endosome to lysosome transport;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R2H7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES21-1", "uniprot_id": [ { "id": "SAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES21", "type": "external" } ], "mass": 67039.0, "length": 587, "protein_name": "Phosphatidylinositol-3-phosphatase SAC1", "gene_name": "Sacm1l", "organism": "Rat", "refseq_name": "phosphatidylinositol-3-phosphatase SAC1 isoform 1", "refseq_ac": [ { "id": "NP_446250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446250", "type": "external" } ], "gene_names_uniprotkb": "Sacm1l; Sac1", "gene_names_refseq": "Sac1; Sacm1l", "protein_names_uniprotkb": "Phosphatidylinositol-3-phosphatase SAC1; 3.1.3.64; Phosphatidylinositol-4-phosphate phosphatase; Suppressor of actin mutations 1-like protein", "protein_names_refseq": "SAC1 suppressor of actin mutations 1-like; phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1 isoform 1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; suppressor of actin mutations 1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116482); (R-RNO-1483248); (R-RNO-1660514)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10887188;27044890", "class_list": "", "function": "Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10887188, PubMed:27044890). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0046856 phosphatidylinositol dephosphorylation;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ES21-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKM5-1", "uniprot_id": [ { "id": "S1PR5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKM5", "type": "external" } ], "mass": 42369.0, "length": 400, "protein_name": "Sphingosine 1-phosphate receptor 5", "gene_name": "S1pr5", "organism": "Rat", "refseq_name": "sphingosine 1-phosphate receptor 5", "refseq_ac": [ { "id": "NP_068543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068543", "type": "external" } ], "gene_names_uniprotkb": "S1pr5; Edg8; Nrg1", "gene_names_refseq": "Edg-8; Edg8; S1pr5", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 5; Endothelial differentiation G protein-coupled receptor 8; NRG-1; Nerve growth factor-regulated G protein-coupled receptor 1; S1P receptor 5; S1P receptor Edg-8; S1P5; Sphingosine 1-phosphate receptor Edg-8", "protein_names_refseq": "NRG-1; S1P receptor 5; S1P receptor Edg-8; S1P5; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; nerve growth factor-regulated G-protein-coupled receptor 1; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8", "tax_id": 10116, "disease": "", "pathway": " (rno:60399); (R-RNO-418594); (R-RNO-419408)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10532805;10799507;11069896;11967257;12234605;15703400;15741218;18294150;22673903;22972346", "class_list": "", "function": "Differences between hS1P(5) and rS1P(5) will be an important point to be considered in the development of selective receptor antagonists., [RefSeq, PubMed]; Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell., [RefSeq, PubMed]; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G proteins. Displays antiproliferative effects in transfected CHO-K1 and HEK293 cells., [UniProtKB]; SphK1 has a role in regulating degranulation and motility of rat mast cells by desensitizing S1P receptors, [RefSeq, PubMed]; The LOC290876-encoded gene product (EDG-8) has distinct roles in the nucleus during the processes of spermatocyte maturation and spermatid production in meiosis., [RefSeq, PubMed]; The immune modulator FTY720 targets sphingosine 1-phosphate receptors., [RefSeq, PubMed]; These data demonstrate novel roles of S1P(1R,) which include regulating emigration and modulating lymphocyte activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY79", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0045664 regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JKM5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMJ4-1", "uniprot_id": [ { "id": "PRP19_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMJ4", "type": "external" } ], "mass": 55239.0, "length": 504, "protein_name": "Pre-mRNA-processing factor 19", "gene_name": "Prpf19", "organism": "Rat", "refseq_name": "pre-mRNA-processing factor 19", "refseq_ac": [ { "id": "NP_647549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647549", "type": "external" } ], "gene_names_uniprotkb": "Prpf19; Prp19", "gene_names_refseq": "Prp19; Prpf19", "protein_names_uniprotkb": "Pre-mRNA-processing factor 19; 2.3.2.27; Neuronal differentiation-related gene protein; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19", "protein_names_refseq": "PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog; RING-type E3 ubiquitin transferase PRP19; neuronal differentiation-related gene protein; pre-mRNA-processing factor 19", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:246216); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-72163)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "16352598;20629186;23769735", "class_list": "", "function": "These results indicate that PRP19beta activates the gp130/Janus kinase (JAK)/STAT signaling pathway during astrocyte differentiation via PTP1B ubiquitination, [RefSeq, PubMed]; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (By similarity). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (PubMed:16352598)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B7C6", "ec_number_list": [ { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005819 spindle;GO:0016607 nuclear speck", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0008610 lipid biosynthetic process;GO:0045665 negative regulation of neuron differentiation;GO:0045666 positive regulation of neuron differentiation;GO:0000244 spliceosomal tri-snRNP complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JMJ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTW8-1", "uniprot_id": [ { "id": "S23A2_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTW8", "type": "external" } ], "mass": 70070.0, "length": 647, "protein_name": "Solute carrier family 23 member 2", "gene_name": "Slc23a2", "organism": "Rat", "refseq_name": "solute carrier family 23 member 2", "refseq_ac": [ { "id": "NP_059012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059012", "type": "external" } ], "gene_names_uniprotkb": "Slc23a2; Svct2", "gene_names_refseq": "SVCT2; Slc23a2", "protein_names_uniprotkb": "Solute carrier family 23 member 2; Na(+)/L-ascorbic acid transporter 2; Sodium-dependent vitamin C transporter 2", "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 2; sodium-coupled ascorbic acid transporter 2; sodium-dependent vitamin C transporter 2; solute carrier family 23 (ascorbic acid transporter), member 2; solute carrier family 23 (nucleobase transporters), member 2; solute carrier family 23 member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:50622); (R-RNO-196836)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10331392;22673903;22763122;23708151;24739976;27085842;28942474", "class_list": "", "function": "Expression and localization of sodium-dependent vitamin C transporter-2 in the sarcolemma is reduced by doxorubicin, a change blunted by vitamin C supplementation., [RefSeq, PubMed]; Expression of SVCT2 was upregulated in neurons after middle cerebral artery occlusion and reperfusion in the nondiabetic cortex, accompanied by an increase in total ascorbic acid in the tissue, and these responses were suppressed in the diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]; Metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin, [RefSeq, PubMed]; SVCT2 is heterogeneously induced in reactive astrogliosis generated in different pathologies affecting the central nervous system., [RefSeq, PubMed]; Sodium/ascorbate cotransporter (PubMed:10331392). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity)., [UniProtKB, PubMed, UniProtKB]; We speculate that SVCT2, possibly regulated by JNK/p38 MAPKs, NF-kappaB signaling and miR-125a-5p, has a neuroprotective effect against EtOH-induced oxidative stress. Promotion of SVCT2 expression or stimulation of SVCT2 activity may be a promising therapeutic strategy for the prevention of EtOH-associated neurodegeneration., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008520 L-ascorbate:sodium symporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0015882 L-ascorbic acid transmembrane transport;GO:0006979 response to oxidative stress;GO:0007155 cell adhesion;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9WTW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54282-1", "uniprot_id": [ { "id": "CAC1A_RAT", "url": "https://www.uniprot.org/uniprot/P54282", "type": "external" } ], "mass": 251527.0, "length": 2212, "protein_name": "Voltage-dependent P/Q-type calcium channel subunit alpha-1A", "gene_name": "Cacna1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cacna1a; Cach4; Cacn3; Cacnl1a4", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent P/Q-type calcium channel subunit alpha-1A; BI; Brain calcium channel I; Calcium channel, L type, alpha-1 polypeptide, isoform 4; RBA-I; Rat brain class A; Voltage-gated calcium channel subunit alpha Cav2.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Lambert-Eaton myasthenic syndrome (Disease Ontology:DOID:0050214); childhood electroclinical syndrome (Disease Ontology:DOID:0050704); cerebellar ataxia (Disease Ontology:DOID:0050753); generalized dystonia (Disease Ontology:DOID:0050835); hereditary ataxia (Disease Ontology:DOID:0050951); spinocerebellar ataxia 6 (Disease Ontology:DOID:0050956); episodic ataxia type 2 (Disease Ontology:DOID:0050990); familial hemiplegic migraine (Disease Ontology:DOID:0060178); primary coenzyme Q10 deficiency 8 (Disease Ontology:DOID:0070245); absence epilepsy (Disease Ontology:DOID:0070309); developmental and epileptic encephalopathy 42 (Disease Ontology:DOID:0080454); autosomal recessive distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0081428); familial hemiplegic migraine 1 (Disease Ontology:DOID:0111181); migraine with aura (Disease Ontology:DOID:10024); childhood absence epilepsy (Disease Ontology:DOID:1825); epilepsy (Disease Ontology:DOID:1826); generalized epilepsy (Disease Ontology:DOID:1827); temporal lobe epilepsy (Disease Ontology:DOID:3328); migraine (Disease Ontology:DOID:6364)", "pathway": " (rno:25398); (R-RNO-112308); (R-RNO-422356)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11865310;1279681;1311418;1648226;1692134;22673903", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q01541", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0019905 syntaxin binding;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0050770 regulation of axonogenesis;GO:0030644 intracellular chloride ion homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54282-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RJR6-1", "uniprot_id": [ { "id": "RTN3_RAT", "url": "https://www.uniprot.org/uniprot/Q6RJR6", "type": "external" } ], "mass": 101517.0, "length": 940, "protein_name": "Reticulon-3", "gene_name": "Rtn3", "organism": "Rat", "refseq_name": "reticulon-3 isoform A1", "refseq_ac": [ { "id": "NP_001009953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009953", "type": "external" } ], "gene_names_uniprotkb": "Rtn3", "gene_names_refseq": "Rtn3", "protein_names_uniprotkb": "Reticulon-3", "protein_names_refseq": "reticulon-3 isoform A1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:140945); (R-RNO-8849932)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12832288;14746891;15946766;19665976;19681166;22673903;29756473;34440784;34645803", "class_list": "", "function": "May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition., [UniProtKB, UniProtKB]; Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and Functional Recovery after Traumatic Injury. Publication Status: Online-Only, [RefSeq, PubMed]; PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Publication Status: Online-Only, [RefSeq, PubMed]; RTN3 may play an important role in developing axons and also in some glial cells such as Muller cells., [RefSeq, PubMed]; RTN3 regulates very low density lipoprotein (VLDL) secretion by controlling VLDL transport vesicle-mediated endoplasmic reticulum-to-Golgi transport of nascent VLDL., [RefSeq, PubMed]; Results show that reticulon 3 may play a role in the trafficking of the synaptic adhesion-like molecules family of adhesion molecules, [RefSeq, PubMed]; This gene encodes a member of the reticulon family, a large group of membrane-bound proteins that primarily localize to the endoplasmic reticulum with a small subpopulation at the cell surface. These proteins play roles in endocytosis, exocytosis, trafficking and neuronal outgrowth. Proteins belonging to this family are characterized by a carboxy-terminal reticulon homology domain that consists of a small hydrophilic loop flanked by hydrophobic regions. In rat, this protein has been shown to interact with two members of the synaptic adhesion-like molecule family, suggesting that it may function in trafficking of these proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6R3;Q8VBU0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0006915 apoptotic process;GO:1902430 negative regulation of amyloid-beta formation;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6RJR6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812E9-1", "uniprot_id": [ { "id": "GPM6A_RAT", "url": "https://www.uniprot.org/uniprot/Q812E9", "type": "external" } ], "mass": 31196.0, "length": 278, "protein_name": "Neuronal membrane glycoprotein M6-a", "gene_name": "Gpm6a", "organism": "Rat", "refseq_name": "neuronal membrane glycoprotein M6-a isoform 1", "refseq_ac": [ { "id": "NP_835206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835206", "type": "external" } ], "gene_names_uniprotkb": "Gpm6a; m6a", "gene_names_refseq": "Gpm6a; M6a", "protein_names_uniprotkb": "Neuronal membrane glycoprotein M6-a; M6a", "protein_names_refseq": "neuronal membrane glycoprotein M6-a isoform 1; neuronal membrane glycoprotein M6-a", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:306439)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12359212;15326124;16286650;17548356;18241840;19180239;19737934;20074218;21426347;22673903;25940868;26809475;27793698;36943192;37189342", "class_list": "", "function": "Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Formation of filopodia by membrane glycoprotein M6a (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1., [RefSeq, PubMed]; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation., [RefSeq, PubMed]; M6a is an axonal component of glutamatergic neurons and that it is localized to distinct sites of the axonal plasma membrane of pyramidal and granule cells, [RefSeq, PubMed]; M6a plays an important role in neurite outgrowth and filopodium/spine formation and may be, at least in part, responsible for plastic alterations found in the hippocampus of chronically stressed animals, [RefSeq, PubMed]; Overexpression of M6a is accompanied by an increase in spine density, particularly in mature spines., [RefSeq, PubMed]; Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats., [RefSeq, PubMed]; We analyzed the functional contribution of transmembrane domains (TMDs) of the neuronal membrane glycoprotein M6a, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0003407 neural retina development;GO:0031175 neuron projection development;GO:0048863 stem cell differentiation;GO:0001764 neuron migration;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q812E9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QW30-1", "uniprot_id": [ { "id": "NOTC2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QW30", "type": "external" } ], "mass": 265370.0, "length": 2471, "protein_name": "Neurogenic locus notch homolog protein 2", "gene_name": "Notch2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Notch2", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurogenic locus notch homolog protein 2; Notch 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); brain cancer (Disease Ontology:DOID:1319); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); Hajdu-Cheney syndrome (Disease Ontology:DOID:2736); adenocarcinoma (Disease Ontology:DOID:299); central nervous system cancer (Disease Ontology:DOID:3620); Alagille syndrome (Disease Ontology:DOID:9245); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29492)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11438922;11577080;1295745;22673903", "class_list": "", "function": "Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0005509 calcium ion binding;GO:0051059 NF-kappaB binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0072574 hepatocyte proliferation;GO:0071228 cellular response to tumor cell;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QW30-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02631-1", "uniprot_id": [ { "id": "ONCO_RAT", "url": "https://www.uniprot.org/uniprot/P02631", "type": "external" } ], "mass": 12188.0, "length": 109, "protein_name": "Oncomodulin", "gene_name": "Ocm", "organism": "Rat", "refseq_name": "oncomodulin", "refseq_ac": [ { "id": "NP_037127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037127", "type": "external" } ], "gene_names_uniprotkb": "Ocm", "gene_names_refseq": "OM; Ocm2; Ocm", "protein_names_uniprotkb": "Oncomodulin; OM; Parvalbumin beta", "protein_names_refseq": "oncmodulin; oncomodulin 2; oncomodulin; parvalbumin beta", "tax_id": 10116, "disease": "", "pathway": " (rno:25503)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "17766386;19075559;2231727;2474657;33419032;3558395;3571255;6617664;8487302", "class_list": "", "function": "Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions., [UniProtKB]; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions., [UniProtKB, UniProtKB, UniProtKB]; Leucine 85 is an important determinant of divalent ion affinity in rat beta-parvalbumin, [RefSeq, PubMed]; Solution structure of Ca2+-free oncomodulin is reported., [RefSeq, PubMed]; The Highly Conservative Cysteine of Oncomodulin as a Feasible Redox Sensor. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009611 response to wounding;GO:0090102 cochlea development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02631-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51638-1", "uniprot_id": [ { "id": "CAV3_RAT", "url": "https://www.uniprot.org/uniprot/P51638", "type": "external" } ], "mass": 17402.0, "length": 151, "protein_name": "Caveolin-3", "gene_name": "Cav3", "organism": "Rat", "refseq_name": "caveolin-3", "refseq_ac": [ { "id": "NP_062028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062028", "type": "external" } ], "gene_names_uniprotkb": "Cav3", "gene_names_refseq": "Cav3", "protein_names_uniprotkb": "Caveolin-3", "protein_names_refseq": "caveolin-3", "tax_id": 10116, "disease": "rippling muscle disease 2 (Disease Ontology:DOID:0060255); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307); long QT syndrome 9 (Disease Ontology:DOID:0110650); distal myopathy Tateyama type (Disease Ontology:DOID:0111191); isolated elevated serum creatine phosphokinase levels (Disease Ontology:DOID:0111338); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); myocardial infarction (Disease Ontology:DOID:5844); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:29161)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15277200;24567387;26497963;28825318;29101175;29486470;31050077;8567687", "class_list": "", "function": "Cav3 depletion in cardiac fibroblasts induced an increase in collagen content, cell proliferation, and phenotypic conversion of fibroblasts to myofibroblasts. Conversely, Cav3 overexpression in cardiac fibroblasts was shown to inhibit angiotensin II-mediated excessive collagen deposition through protein kinase C-epsilon inactivation., [RefSeq, PubMed]; ERalphaDelta4, an ERalpha splice variant missing exon4, interacts with caveolin-3 and mGluR2/3., [RefSeq, PubMed]; In ventricular myocytes from normal hearts, regulation of the L-type Ca(2+) current by beta2-adrenoceptors and the constitutive regulation by caveolin-3 is localized to the t-tubules. In heart failure, the regulation of L-type Ca(2+) current by beta2-adrenoceptors is redistributed to the surface membrane, and the constitutive regulation by caveolin-3 is lost., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae., [UniProtKB, UniProtKB, UniProtKB]; Suggest a novel role for striatin in regulating cardiomyocyte spontaneous contraction rate and the dynamics of the STRN/caveolin-3/calmodulin complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0071253 connexin binding;GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010831 positive regulation of myotube differentiation;GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0031579 membrane raft organization;GO:0035995 detection of muscle stretch", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51638-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61107-1", "uniprot_id": [ { "id": "RAB14_RAT", "url": "https://www.uniprot.org/uniprot/P61107", "type": "external" } ], "mass": 23927.0, "length": 215, "protein_name": "Ras-related protein Rab-14", "gene_name": "Rab14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab14", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-14; 3.6.5.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:94197); (R-RNO-1660499); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "1313420;15004230;22673903", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (PubMed:15004230). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P35287;Q969L0;Q9UI11", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032880 regulation of protein localization;GO:0016192 vesicle-mediated transport;GO:0007589 body fluid secretion;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P61107-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA68-1", "uniprot_id": [ { "id": "OPA1_RAT", "url": "https://www.uniprot.org/uniprot/Q2TA68", "type": "external" } ], "mass": 111307.0, "length": 960, "protein_name": "Dynamin-like GTPase OPA1, mitochondrial", "gene_name": "Opa1", "organism": "Rat", "refseq_name": "dynamin-like GTPase OPA1, mitochondrial isoform 4 precursor", "refseq_ac": [ { "id": "NP_598269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598269", "type": "external" } ], "gene_names_uniprotkb": "Opa1", "gene_names_refseq": "Opa1", "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5; Optic atrophy protein 1 homolog", "protein_names_refseq": "RN protein; dynamin-like 120 kDa protein, mitochondrial; dynamin-like GTPase OPA1, mitochondrial isoform 4 precursor; dynamin-like GTPase OPA1, mitochondrial; mitochondrial OPA1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; optic atrophy protein 1 homolog", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:171116); (R-RNO-169911)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15505078;16249510;16778770;32901846;33119220;33383158;37814860;38986925", "class_list": "", "function": "Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats., [RefSeq, PubMed]; Constitutes the soluble short form (S-OPA1) generated by cleavage by OMA1, which plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). The transmembrane long form (L-OPA1) and the S-OPA1 form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Excess levels of S-OPA1 produced by cleavage by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, thereby inhibiting mitochondrial fusion (By similarity). Involved in mitochondrial safeguard in response to transient mitochondrial membrane depolarization by mediating flickering: cleavage by OMA1 leads to excess production of S-OPA1, preventing mitochondrial hyperfusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Constitutes the transmembrane long form (L-OPA1) that plays a central role in mitochondrial inner membrane fusion and cristae morphology (By similarity). L-OPA1 and the soluble short form (S-OPA1) form higher-order helical assemblies that coordinate the fusion of mitochondrial inner membranes (By similarity). Inner membrane-anchored L-OPA1 molecules initiate membrane remodeling by recruiting soluble S-OPA1 to rapidly polymerize into a flexible cylindrical scaffold encaging the mitochondrial inner membrane (By similarity). Once at the membrane surface, the formation of S-OPA1 helices induce bilayer curvature (By similarity). OPA1 dimerization through the paddle region, which inserts into cardiolipin-containing membrane, promotes GTP hydrolysis and the helical assembly of a flexible OPA1 lattice on the membrane, which drives membrane curvature and mitochondrial fusion (By similarity). Plays a role in the maintenance and remodeling of mitochondrial cristae, some invaginations of the mitochondrial inner membrane that provide an increase in the surface area (By similarity). Probably acts by forming helical filaments at the inside of inner membrane tubes with the shape and dimensions of crista junctions (By similarity). The equilibrium between L-OPA1 and S-OPA1 influences cristae shape and morphology: increased L-OPA1 levels promote cristae stacking and elongated mitochondria, while increased S-OPA1 levels correlated with irregular cristae packing and round mitochondria shape (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Differentiation activates mitochondrial OPA1 processing in myoblast cell lines., [RefSeq, PubMed]; Dynamin-related GTPase that is essential for normal mitochondrial morphology by mediating fusion of the mitochondrial inner membranes, regulating cristae morphology and maintaining respiratory chain function (PubMed:16778770). Exists in two forms: the transmembrane, long form (Dynamin-like GTPase OPA1, long form; L-OPA1), which is tethered to the inner mitochondrial membrane, and the short soluble form (Dynamin-like GTPase OPA1, short form; S-OPA1), which results from proteolytic cleavage and localizes in the intermembrane space (By similarity). Both forms (L-OPA1 and S-OPA1) cooperate to catalyze the fusion of the mitochondrial inner membrane (By similarity). The equilibrium between L-OPA1 and S-OPA1 is essential: excess levels of S-OPA1, produced by cleavage by OMA1 following loss of mitochondrial membrane potential, lead to an impaired equilibrium between L-OPA1 and S-OPA1, inhibiting mitochondrial fusion (By similarity). The balance between L-OPA1 and S-OPA1 also influences cristae shape and morphology (By similarity). Involved in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing by PARL in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Acts as a regulator of T-helper Th17 cells, which are characterized by cells with fused mitochondria with tight cristae, by mediating mitochondrial membrane remodeling: OPA1 is required for interleukin-17 (IL-17) production (By similarity). Its role in mitochondrial morphology is required for mitochondrial genome maintenance (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Isoforms that contain the alternative exon 4b are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial OPA1 cleavage is reversibly activated by differentiation of H9c2 cardiomyoblasts., [RefSeq, PubMed]; Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression., [RefSeq, PubMed]; [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08681;Q5MPP1;Q5MPP2;Q5QJE9;Q6B435;Q6R611", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0097749 membrane tubulation;GO:1900078 positive regulation of cellular response to insulin stimulus;GO:1904643 response to curcumin;GO:0032740 positive regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2TA68-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2S0-1", "uniprot_id": [ { "id": "RSRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2S0", "type": "external" } ], "mass": 34516.0, "length": 300, "protein_name": "Arginine/serine-rich protein 1", "gene_name": "Rsrp1", "organism": "Rat", "refseq_name": "arginine/serine-rich protein 1", "refseq_ac": [ { "id": "NP_001014215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014215", "type": "external" } ], "gene_names_uniprotkb": "Rsrp1", "gene_names_refseq": "RGD1359529; Rsrp1", "protein_names_uniprotkb": "Arginine/serine-rich protein 1", "protein_names_refseq": "UPF0471 protein C1orf63 homolog; arginine/serine-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362626)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000245 spliceosomal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2S0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63472-1", "uniprot_id": [ { "id": "KCNH1_RAT", "url": "https://www.uniprot.org/uniprot/Q63472", "type": "external" } ], "mass": 108291.0, "length": 962, "protein_name": "Voltage-gated delayed rectifier potassium channel KCNH1", "gene_name": "Kcnh1", "organism": "Rat", "refseq_name": "voltage-gated delayed rectifier potassium channel KCNH1", "refseq_ac": [ { "id": "NP_113930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113930", "type": "external" } ], "gene_names_uniprotkb": "Kcnh1; EAG1; Eag", "gene_names_refseq": "Kcnh1", "protein_names_uniprotkb": "Voltage-gated delayed rectifier potassium channel KCNH1; EAG channel 1; Ether-a-go-go potassium channel 1; Potassium voltage-gated channel subfamily H member 1; Voltage-gated potassium channel subunit Kv10.1; r-eag", "protein_names_refseq": "EAG channel 1; EAG1; ether-a-go-go potassium channel 1; potassium channel, voltage gated eag related subfamily H, member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; voltage-gated delayed rectifier potassium channel KCNH1; voltage-gated potassium channel subunit Kv10.1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); epilepsy (Disease Ontology:DOID:1826); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:65198); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10718922;22841712;23144454;24495567;25556795;27516594;31490124;33647316;36331999;7925287;9400421;9722534", "class_list": "", "function": "Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation., [RefSeq, PubMed]; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:24495567, PubMed:27516594, PubMed:31490124, PubMed:7925287, PubMed:9400421). The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve (By similarity). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The authors demonstrate that the Eag1 intracellular domains are not required for voltage-dependent gating but likely interact with the transmembrane voltage sensors to modulate gating. Publication Status: Online-Only, [RefSeq, PubMed]; This study determined the single-particle cryo-electron microscopy structure of mammalian K(v)10.1, or Eag1, bound to the channel inhibitor calmodulin, at 3.78 angstrom resolution., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0001964 startle response;GO:0042127 regulation of cell population proliferation;GO:0042391 regulation of membrane potential;GO:0034220 monoatomic ion transmembrane transport;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q63472-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q703I1-1", "uniprot_id": [ { "id": "OSER1_RAT", "url": "https://www.uniprot.org/uniprot/Q703I1", "type": "external" } ], "mass": 32008.0, "length": 291, "protein_name": "Oxidative stress-responsive serine-rich protein 1", "gene_name": "Oser1", "organism": "Rat", "refseq_name": "oxidative stress-responsive serine-rich protein 1", "refseq_ac": [ { "id": "NP_963854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963854", "type": "external" } ], "gene_names_uniprotkb": "Oser1; Osr1; Perit1", "gene_names_refseq": "Oser1; Perit1; RGD1303142; osr1", "protein_names_uniprotkb": "Oxidative stress-responsive serine-rich protein 1; Oxidative stress-responsive protein 1; Peroxide-inducible transcript 1 protein", "protein_names_refseq": "oxidative stress responsive 1; oxidative stress-responsive protein 1; oxidative stress-responsive serine-rich protein 1; peroxide-inducible transcript 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:296346)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;17148688", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q703I1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZQ5-1", "uniprot_id": [ { "id": "CCN3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZQ5", "type": "external" } ], "mass": 38510.0, "length": 351, "protein_name": "CCN family member 3", "gene_name": "Ccn3", "organism": "Rat", "refseq_name": "CCN family member 3 precursor", "refseq_ac": [ { "id": "NP_110495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110495", "type": "external" } ], "gene_names_uniprotkb": "Ccn3; Nov", "gene_names_refseq": "Ccn3; Nov", "protein_names_uniprotkb": "CCN family member 3; Cellular communication network factor 3; Nephroblastoma-overexpressed gene protein homolog; NovH; Protein NOV homolog", "protein_names_refseq": "CCN family member 3 precursor; CCN family member 3; nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein homolog; novH; protein NOV homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:81526)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10570975;12064632;15181016;15213231;21871891;22353423;27853940;30149912;31494663", "class_list": "", "function": "CCN3 is expressed by articular chondrocytes in normal rat knees, whereas it is rapidly down-regulated in osteoarthritic knees., [RefSeq, PubMed]; Data show that RNA levels of cyr61 and Nov are upregulated in C6 cells transfected with connexin 43., [RefSeq, PubMed]; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (By similarity). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (By similarity). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:22353423). Brain osteoanabolic hormone. During lactation, maintains the maternal skeleton and viability of offspring (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; These results suggest that CCN3 is a secreted protein of the ductus arteriosus (DA) smooth muscle cells induced by PGE2 to suppress intimal cushion formation of the DA., [RefSeq, PubMed]; This study aimed to investigate the role of TNC and CCN3 as prognostic factors for post hepatectomy liver failure (PHLF) in a rat model of partial hepatectomy and 50 patients following partial hepatectomy. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0005112 Notch binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0071603 endothelial cell-cell adhesion;GO:1904057 negative regulation of sensory perception of pain;GO:0090027 negative regulation of monocyte chemotaxis;GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63088-1", "uniprot_id": [ { "id": "PP1G_RAT", "url": "https://www.uniprot.org/uniprot/P63088", "type": "external" } ], "mass": 36984.0, "length": 323, "protein_name": "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "gene_name": "Ppp1cc", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1", "refseq_ac": [ { "id": "NP_071943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071943", "type": "external" } ], "gene_names_uniprotkb": "Ppp1cc", "gene_names_refseq": "PP-1G; Ppp1cc1; Ppp1cc", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; 3.1.3.16; PP-1G; Protein phosphatase 1C catalytic subunit", "protein_names_refseq": "protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; protein serine-threonine phosphatase catalytic subunit PP-1b; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1; serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); cancer (Disease Ontology:DOID:162); hereditary elliptocytosis (Disease Ontology:DOID:2373); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24669); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 9, "publication_id_list": "10504266;10585469;17636256;2177460;26668322;29033188;7720853;8393674;9841883", "class_list": "", "function": "Data suggest that Ncx1 (sodium-calcium exchanger 1) is substrate-specifying Pp1c regulator protein, regulating Ncx1 activity via Ser-68-phospholemman (Plm) dephosphorylation in cardiomyocytes; Plm/Ncx1/Pp1c complex is up-regulated in heart failure., [RefSeq, PubMed]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Regulates the recruitment of the SKA complex to kinetochores (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). Dephosphorylates MKI67 at the onset of anaphase (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Required for normal male fertility., [UniProtKB, UniProtKB]; That PPP1CC promoted astrocyte and microglia proliferation after inflammation, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09186;O09189;P37139;Q64679", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0007283 spermatogenesis;GO:0046822 regulation of nucleocytoplasmic transport;GO:0051301 cell division;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P63088-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34158-1", "uniprot_id": [ { "id": "CFTR_RAT", "url": "https://www.uniprot.org/uniprot/P34158", "type": "external" } ], "mass": 167830.0, "length": 1476, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "Cftr", "organism": "Rat", "refseq_name": "cystic fibrosis transmembrane conductance regulator", "refseq_ac": [ { "id": "NP_113694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113694", "type": "external" } ], "gene_names_uniprotkb": "Cftr; Abcc7", "gene_names_refseq": "Cftr; RGD1561193", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; cAMP-dependent chloride channel", "protein_names_refseq": "ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator homolog; cystic fibrosis transmembrane conductance regulator", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); bronchiectasis 1 (Disease Ontology:DOID:0080526); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111862); autosomal recessive congenital bilateral absence of vas deferens (Disease Ontology:DOID:0111864); cholelithiasis (Disease Ontology:DOID:10211); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); prostatic hypertrophy (Disease Ontology:DOID:11132); osteoporosis (Disease Ontology:DOID:11476); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); lung cancer (Disease Ontology:DOID:1324); typhoid fever (Disease Ontology:DOID:13258); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); pulmonary sarcoidosis (Disease Ontology:DOID:13406); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); duodenal ulcer (Disease Ontology:DOID:1724); pancreatic cancer (Disease Ontology:DOID:1793); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); alcoholic pancreatitis (Disease Ontology:DOID:4988); salpingitis (Disease Ontology:DOID:5733); dental enamel hypoplasia (Disease Ontology:DOID:693); gastrointestinal system disease (Disease Ontology:DOID:77); lung disease (Disease Ontology:DOID:850); diabetes mellitus (Disease Ontology:DOID:9351); bronchiectasis (Disease Ontology:DOID:9563)", "pathway": " (rno:24255); (R-RNO-382556); (R-RNO-5627083); (R-RNO-5689880); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9013406); (R-RNO-9646399)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "11053017;11707463;12519745;1282491;12917688;14679199;22673903;29453757;30659401;33264332;33571554;33926975;35266910;35676569;7526924", "class_list": "", "function": "CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model., [RefSeq, PubMed]; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Heterogeneous expression of CFTR in insulin-secreting beta-cells of the normal human islet. Erratum:[PLoS One. 2023 Jul 7;18(7):e0288417. doi: 10.1371/journal.pone.0288417. PMID: 37418383] Publication Status: Online-Only, [RefSeq, PubMed]; Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; The inhibition of CFTR in the descended testis of SD rats with unilateral cryptorchidism induced by di-(2-ethylhexyl) phthalate (DEHP)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2IBD3", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0019869 chloride channel inhibitor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0071320 cellular response to cAMP;GO:0030324 lung development;GO:0034605 cellular response to heat;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P34158-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15083-1", "uniprot_id": [ { "id": "PIGR_RAT", "url": "https://www.uniprot.org/uniprot/P15083", "type": "external" } ], "mass": 84798.0, "length": 769, "protein_name": "Polymeric immunoglobulin receptor", "gene_name": "Pigr", "organism": "Rat", "refseq_name": "polymeric immunoglobulin receptor precursor", "refseq_ac": [ { "id": "NP_036855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036855", "type": "external" } ], "gene_names_uniprotkb": "Pigr", "gene_names_refseq": "Pigr; RNPIGR2; pIgA-R", "protein_names_uniprotkb": "Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor", "protein_names_refseq": "poly-Ig receptor; polymeric IgA receptor; polymeric immunoglobulin receptor precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:25046); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "21454685;22673903;2776882;32012687", "class_list": "", "function": "Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001792 polymeric immunoglobulin receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0005154 epidermal growth factor receptor binding;GO:0001790 polymeric immunoglobulin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0055038 recycling endosome membrane;GO:0071751 secretory IgA immunoglobulin complex", "go_biological_process": "GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0038093 Fc receptor signaling pathway;GO:0007165 signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0043113 receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M5N7-1", "uniprot_id": [ { "id": "KI21B_RAT", "url": "https://www.uniprot.org/uniprot/F1M5N7", "type": "external" } ], "mass": 182563.0, "length": 1634, "protein_name": "Kinesin-like protein KIF21B", "gene_name": "Kif21b", "organism": "Rat", "refseq_name": "kinesin-like protein KIF21B isoform X2", "refseq_ac": [ { "id": "XP_063128267", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063128267", "type": "external" } ], "gene_names_uniprotkb": "Kif21b", "gene_names_refseq": "Kif21b", "protein_names_uniprotkb": "Kinesin-like protein KIF21B", "protein_names_refseq": "kinesin-like protein KIF21B isoform X2", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22673903;25172774;29393594", "class_list": "", "function": "Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030426 growth cone;GO:0005871 kinesin complex", "go_biological_process": "GO:0007420 brain development;GO:0007018 microtubule-based movement;GO:0022038 corpus callosum development;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0098934 retrograde dendritic transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1M5N7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35828-1", "uniprot_id": [ { "id": "CORO7_RAT", "url": "https://www.uniprot.org/uniprot/O35828", "type": "external" } ], "mass": 100782.0, "length": 922, "protein_name": "Coronin-7", "gene_name": "Coro7", "organism": "Rat", "refseq_name": "coronin-7", "refseq_ac": [ { "id": "NP_001178568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178568", "type": "external" } ], "gene_names_uniprotkb": "Coro7", "gene_names_refseq": "Coro7; Crn7", "protein_names_uniprotkb": "Coronin-7; 70 kDa WD repeat tumor rejection antigen; Crn7", "protein_names_refseq": "70 kDa WD repeat tumor rejection antigen; coronin-7-like; coronin-7; tumor specific antigen 70 kDa", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:192276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9703019", "class_list": "", "function": "F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZUE2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0016477 cell migration;GO:0030041 actin filament polymerization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35828-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R044-1", "uniprot_id": [ { "id": "NPHN_RAT", "url": "https://www.uniprot.org/uniprot/Q9R044", "type": "external" } ], "mass": 136281.0, "length": 1252, "protein_name": "Adhesion molecule nephrin", "gene_name": "Nphs1", "organism": "Rat", "refseq_name": "adhesion molecule nephrin precursor", "refseq_ac": [ { "id": "NP_072150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072150", "type": "external" } ], "gene_names_uniprotkb": "Nphs1; Nphn", "gene_names_refseq": "Nphs1", "protein_names_uniprotkb": "Adhesion molecule nephrin; Protein nephrosis 1; Renal glomerulus-specific cell adhesion receptor", "protein_names_refseq": "NPHS1 nephrin; adhesion molecule nephrin precursor; adhesion molecule nephrin; nephrosis 1 homolog, nephrin; nephrosis 1, congenital, Finnish type (nephrin); protein nephrosis 1; renal glomerulus-specific cell adhesion receptor", "tax_id": 10116, "disease": "nephrotic syndrome type 1 (Disease Ontology:DOID:0080390); kidney failure (Disease Ontology:DOID:1074); membranous glomerulonephritis (Disease Ontology:DOID:10976); nephrotic syndrome (Disease Ontology:DOID:1184); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:64563); (R-RNO-373753)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10487848;10792613;10820162;11012881;11880318;15994232;16155592;17537921;18256598;19179337;22673903;29959197", "class_list": "", "function": "Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9JIX2;Q9QXX7", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0051393 alpha-actinin binding;GO:0030507 spectrin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0071944 cell periphery;GO:0005604 basement membrane", "go_biological_process": "GO:0036060 slit diaphragm assembly;GO:0007155 cell adhesion;GO:0000165 MAPK cascade;GO:0007254 JNK cascade;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9R044-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08662-1", "uniprot_id": [ { "id": "PI4KA_RAT", "url": "https://www.uniprot.org/uniprot/O08662", "type": "external" } ], "mass": 236920.0, "length": 2096, "protein_name": "Phosphatidylinositol 4-kinase alpha", "gene_name": "Pi4ka", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pi4ka; Pik4ca", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase alpha; 2.7.1.67; PI4-kinase alpha; PI4K-alpha; PtdIns-4-kinase alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); hereditary spastic paraplegia 84 (Disease Ontology:DOID:0112347)", "pathway": " (rno:64161); (R-RNO-1483248); (R-RNO-1660514)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;23229899;8662589", "class_list": "", "function": "Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K2J3", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030660 Golgi-associated vesicle membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0048015 phosphatidylinositol-mediated signaling;GO:0022011 myelination in peripheral nervous system;GO:0036135 Schwann cell migration;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08662-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZGS3-1", "uniprot_id": [ { "id": "OCRL_RAT", "url": "https://www.uniprot.org/uniprot/D3ZGS3", "type": "external" } ], "mass": 104407.0, "length": 902, "protein_name": "Inositol polyphosphate 5-phosphatase OCRL", "gene_name": "Ocrl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ocrl", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol polyphosphate 5-phosphatase OCRL; 3.1.3.36; 3.1.3.56; 3.1.3.86; Inositol polyphosphate 5-phosphatase OCRL-1; OCRL-1; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase", "protein_names_refseq": "", "tax_id": 10116, "disease": "Dent disease 2 (Disease Ontology:DOID:0081454); oculocerebrorenal syndrome (Disease Ontology:DOID:1056)", "pathway": " (R-RNO-1660499); (R-RNO-1660514); (R-RNO-1855183); (R-RNO-1855204); (R-RNO-432722); (R-RNO-8856828); (R-RNO-9013409); (R-RNO-9013423)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "19795375", "class_list": "", "function": "Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" } ], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0052745 inositol phosphate phosphatase activity;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0060271 cilium assembly;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZGS3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70475-1", "uniprot_id": [ { "id": "MYT1L_RAT", "url": "https://www.uniprot.org/uniprot/P70475", "type": "external" } ], "mass": 132926.0, "length": 1187, "protein_name": "Myelin transcription factor 1-like protein", "gene_name": "Myt1l", "organism": "Rat", "refseq_name": "myelin transcription factor 1-like protein", "refseq_ac": [ { "id": "NP_446340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446340", "type": "external" } ], "gene_names_uniprotkb": "Myt1l; Nzf1", "gene_names_refseq": "Myt1l; Nzf-1; Nzf1; Nztf1", "protein_names_uniprotkb": "Myelin transcription factor 1-like protein; MyT1-L; MyT1L; NZF-1; Neural zinc finger factor 1", "protein_names_refseq": "myT1-L; myelin transcription factor 1-like protein; neural zinc finger factor 1; neural zinc finger transcription factor 1", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 39 (Disease Ontology:DOID:0070069)", "pathway": " (rno:116668)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "14744132;8631881;8980226;9373037", "class_list": "", "function": "Structure determination of NZF-1 amino acid residues 487-548 reveals a novel fold for its zinc-binding domain that provides at least a partial explanation for the conservation of two histidine resiues within this sequence family., [RefSeq, PubMed]; Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037). Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "D4A9W2;P70589", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70475-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYK3-1", "uniprot_id": [ { "id": "NRBF2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYK3", "type": "external" } ], "mass": 32558.0, "length": 287, "protein_name": "Nuclear receptor-binding factor 2", "gene_name": "Nrbf2", "organism": "Rat", "refseq_name": "nuclear receptor-binding factor 2", "refseq_ac": [ { "id": "NP_071522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071522", "type": "external" } ], "gene_names_uniprotkb": "Nrbf2", "gene_names_refseq": "Nrbf2", "protein_names_uniprotkb": "Nuclear receptor-binding factor 2; NRBF-2", "protein_names_refseq": "NRBF-2; nuclear receptor-binding factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:58839); (R-RNO-383280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10786636;18619852", "class_list": "", "function": "Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0035032 phosphatidylinositol 3-kinase complex, class III", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0006914 autophagy;GO:0034976 response to endoplasmic reticulum stress;GO:0043550 regulation of lipid kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QYK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49791-1", "uniprot_id": [ { "id": "NU153_RAT", "url": "https://www.uniprot.org/uniprot/P49791", "type": "external" } ], "mass": 152824.0, "length": 1468, "protein_name": "Nuclear pore complex protein Nup153", "gene_name": "Nup153", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nup153", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:25281); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 7, "publication_id_list": "11839768;15703211;18611384;18683930;19505478;22673903;8422679", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0016020 membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0046832 negative regulation of RNA export from nucleus;GO:1990000 amyloid fibril formation;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport;GO:0006405 RNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P49791-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00960-1", "uniprot_id": [ { "id": "NMDE2_RAT", "url": "https://www.uniprot.org/uniprot/Q00960", "type": "external" } ], "mass": 166071.0, "length": 1482, "protein_name": "Glutamate receptor ionotropic, NMDA 2B", "gene_name": "Grin2b", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, NMDA 2B precursor", "refseq_ac": [ { "id": "NP_036706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036706", "type": "external" } ], "gene_names_uniprotkb": "Grin2b", "gene_names_refseq": "GluN2B; Grin2b", "protein_names_uniprotkb": "Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B", "protein_names_refseq": "N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor ionotropic, NMDA 2B precursor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; glutamate receptor, ionotropic, NMDA2B", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 6 (Disease Ontology:DOID:0070036); developmental and epileptic encephalopathy 27 (Disease Ontology:DOID:0080444); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Huntington's disease (Disease Ontology:DOID:12858); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); placental insufficiency (Disease Ontology:DOID:3891); egg allergy (Disease Ontology:DOID:4377); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); hyperhomocysteinemia (Disease Ontology:DOID:9279); cannabis abuse (Disease Ontology:DOID:9505); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24410); (R-RNO-3928662); (R-RNO-438066); (R-RNO-5673001); (R-RNO-8849932); (R-RNO-9609736)", "pathway_count": 6, "publication_count": 85, "publication_id_list": "10.1039/D0MO00044B;10436042;11306676;11588171;11841566;11929923;12391275;12950452;1350383;18694808;18700282;19041929;19383086;19424850;19625512;19850826;19910922;20042082;20497625;20569495;21147838;21215796;21575722;21677647;22301064;22474321;22655064;22673903;22759925;22819974;22960932;22982438;23376245;23585298;23624776;23957788;24090084;24607230;24667898;24769228;24876489;25576965;26256252;26260438;26303340;26441533;26515544;27121999;27127657;27135925;27458189;27487820;27771532;27916457;28094500;28106041;28182698;28283559;28326942;28439098;28948570;29205377;29422059;30400767;30846840;31484535;32386416;32415270;33276724;33281565;33348808;33669305;34106099;38416255;38471625;38764325;38843836;38853550;39085540;7513428;7524561;7569905;9463421;9509416;9647694", "class_list": "", "function": "ALKBH5 modulates bone cancer pain in a rat model by suppressing NR2B expression., [RefSeq, PubMed]; Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:11929923, PubMed:19910922, PubMed:21677647, PubMed:24607230, PubMed:24876489, PubMed:27135925, PubMed:7524561). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:11929923, PubMed:19910922, PubMed:21677647, PubMed:24607230, PubMed:24876489, PubMed:27135925, PubMed:7524561). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:11929923, PubMed:24607230, PubMed:9463421). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage (By similarity). Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats., [RefSeq, PubMed]; GluN2A- and GluN2B-containing pre-synaptic N-methyl-d-aspartate receptors differentially regulate action potential-evoked Ca[2+] influx via modulation of SK channels., [RefSeq, PubMed]; Insular cortex stimulation alleviates neuropathic pain through changes in the expression of collapsin response mediator protein 2 involved in synaptic plasticity., [RefSeq, PubMed]; Molecular mechanism of ligand gating and opening of NMDA receptor., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 23, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 28, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q62684", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0005102 signaling receptor binding;GO:0005262 calcium channel activity;GO:0008270 zinc ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0031223 auditory behavior;GO:1900452 regulation of long-term synaptic depression;GO:0001964 startle response;GO:0051707 response to other organism;GO:0071359 cellular response to dsRNA", "synthesized_glycan_count": 0, "hit_score": 10.9, "record_id": "Q00960-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97587-1", "uniprot_id": [ { "id": "CGRF1_RAT", "url": "https://www.uniprot.org/uniprot/P97587", "type": "external" } ], "mass": 37443.0, "length": 332, "protein_name": "Cell growth regulator with RING finger domain protein 1", "gene_name": "Cgrrf1", "organism": "Rat", "refseq_name": "cell growth regulator with RING finger domain protein 1", "refseq_ac": [ { "id": "NP_446351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446351", "type": "external" } ], "gene_names_uniprotkb": "Cgrrf1; Cgr19", "gene_names_refseq": "Cgr19; Cgrrf1", "protein_names_uniprotkb": "Cell growth regulator with RING finger domain protein 1; Cell growth regulatory gene 19 protein", "protein_names_refseq": "cell growth regulator with RING finger domain protein 1; cell growth regulatory gene 19 protein; cell growth regulatory with ring finger domain", "tax_id": 10116, "disease": "", "pathway": " (rno:116679)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8968090", "class_list": "", "function": "Able to inhibit growth in several cell lines., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; CGR19 appears to be a primary response gene expressed to moderate levels in functional p53 cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005634 nucleus", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97587-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H1UBN0-1", "uniprot_id": [ { "id": "CPNE7_RAT", "url": "https://www.uniprot.org/uniprot/H1UBN0", "type": "external" } ], "mass": 61978.0, "length": 556, "protein_name": "Copine-7", "gene_name": "Cpne7", "organism": "Rat", "refseq_name": "copine-7", "refseq_ac": [ { "id": "NP_001386024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386024", "type": "external" } ], "gene_names_uniprotkb": "Cpne7", "gene_names_refseq": "Cpne7", "protein_names_uniprotkb": "Copine-7; Copine VII", "protein_names_refseq": "copine VII; copine-7", "tax_id": 10116, "disease": "", "pathway": " (rno:361433); (R-RNO-1483206)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26175110", "class_list": "", "function": "Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes., [UniProtKB, UniProtKB]; The second C2-domain of copine-7 is responsible for calcium-dependent membrane association., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "H1UBN0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35180-1", "uniprot_id": [ { "id": "SH3G3_RAT", "url": "https://www.uniprot.org/uniprot/O35180", "type": "external" } ], "mass": 39166.0, "length": 347, "protein_name": "Endophilin-A3", "gene_name": "Sh3gl3", "organism": "Rat", "refseq_name": "endophilin-A3 isoform 1", "refseq_ac": [ { "id": "NP_001401305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401305", "type": "external" } ], "gene_names_uniprotkb": "Sh3gl3; Sh3d2c1; Sh3p13", "gene_names_refseq": "SH3P13; Sh3d2c1; Sh3gl3", "protein_names_uniprotkb": "Endophilin-A3; Endophilin-3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3; SH3p13", "protein_names_refseq": "SH3 domain protein 2 C1; SH3 domain protein 2C; SH3 domain-containing GRB2-like 3; SH3 domain-containing GRB2-like protein 3; SH3-domain GRB2-like 3; endophilin-3; endophilin-A3 isoform 1; endophilin-A3", "tax_id": 10116, "disease": "", "pathway": " (rno:81921); (R-RNO-182971); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15066995;17088211;22961472;9238017", "class_list": "", "function": "Endophilin III binding to N-type Ca2+ channel carboxy-terminal fragments is Ca2+-independent in clathrin-mediated endocytosis., [RefSeq, PubMed]; Implicated in endocytosis. May recruit other proteins to membranes with high curvature., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35104", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045666 positive regulation of neuron differentiation;GO:0061024 membrane organization;GO:2000369 regulation of clathrin-dependent endocytosis;GO:1900186 negative regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35180-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55096-1", "uniprot_id": [ { "id": "DPP3_RAT", "url": "https://www.uniprot.org/uniprot/O55096", "type": "external" } ], "mass": 83039.0, "length": 738, "protein_name": "Dipeptidyl peptidase 3", "gene_name": "Dpp3", "organism": "Rat", "refseq_name": "dipeptidyl peptidase 3", "refseq_ac": [ { "id": "NP_446200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446200", "type": "external" } ], "gene_names_uniprotkb": "Dpp3; Dpp3l1", "gene_names_refseq": "Dpp3", "protein_names_uniprotkb": "Dipeptidyl peptidase 3; 3.4.14.4; DPP III; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; Enkephalinase B", "protein_names_refseq": "DPP III; dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidyl peptidase 3; dipeptidyl peptidase III; dipeptidyl-peptidase 3; dipeptidylpeptidase III; enkephalinase B", "tax_id": 10116, "disease": "", "pathway": " (rno:114591)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10387075;11027512;11209758;18547641;22683474;35653825;9425109", "class_list": "", "function": "Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (By similarity). Also cleaves Arg-Arg-beta-naphthylamide., [UniProtKB, UniProtKB]; Dipeptidylamino-tripeptidylcarboxypeptidase NEMP3 and DPP3 (DPP III) are the same protein., [RefSeq, PubMed]; Results suggest that the upregulation of serotonergic activity may be related to a lowered brain dipeptidyl peptidase III, alanyl- and arginyl aminopeptidase activity which may have an influence on the cleavage of their physiological substrates., [RefSeq, PubMed]; Structure and activity of Cu(II)-rat dipeptidyl peptidase III, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32Q87", "ec_number_list": [], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55096-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05554-1", "uniprot_id": [ { "id": "CEBPA_RAT", "url": "https://www.uniprot.org/uniprot/P05554", "type": "external" } ], "mass": 37371.0, "length": 358, "protein_name": "CCAAT/enhancer-binding protein alpha", "gene_name": "Cebpa", "organism": "Rat", "refseq_name": "CCAAT/enhancer-binding protein alpha isoform c", "refseq_ac": [ { "id": "NP_001274506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274506", "type": "external" } ], "gene_names_uniprotkb": "Cebpa", "gene_names_refseq": "Cebpa; DBPCEP", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein alpha; C/EBP alpha", "protein_names_refseq": "C/EBP alpha; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha isoform c", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:24252); (R-RNO-9616222)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11672531;12578822;1377818;16735515;1884998;20075868;20176812;2850264;35883192;36132983;37361037;37392202;7926792;8367486", "class_list": "", "function": "C/EBPalpha involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats. Publication Status: Online-Only, [RefSeq, PubMed]; C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARgamma signalling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection. Publication Status: Online-Only, [RefSeq, PubMed]; Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation., [UniProtKB, UniProtKB]; The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway., [RefSeq, PubMed]; This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Aug 2014]., [RefSeq]; Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:11672531, PubMed:16735515, PubMed:20176812, PubMed:8367486). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (By similarity). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:11672531). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:11672531). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (By similarity). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097677 STAT family protein binding;GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0019900 kinase binding", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0030851 granulocyte differentiation;GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P05554-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08523-1", "uniprot_id": [ { "id": "OMP_RAT", "url": "https://www.uniprot.org/uniprot/P08523", "type": "external" } ], "mass": 18853.0, "length": 163, "protein_name": "Olfactory marker protein", "gene_name": "Omp", "organism": "Rat", "refseq_name": "olfactory marker protein", "refseq_ac": [ { "id": "NP_036748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036748", "type": "external" } ], "gene_names_uniprotkb": "Omp", "gene_names_refseq": "Omp", "protein_names_uniprotkb": "Olfactory marker protein; Olfactory neuronal-specific protein", "protein_names_refseq": "olfactory marker protein; olfactory neuronal-specific protein", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:24612)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12054873;2701951;3470751;3753006", "class_list": "", "function": "May act as a modulator of the olfactory signal-transduction cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042277 peptide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08523-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19020-1", "uniprot_id": [ { "id": "DRD3_RAT", "url": "https://www.uniprot.org/uniprot/P19020", "type": "external" } ], "mass": 49516.0, "length": 446, "protein_name": "D(3) dopamine receptor", "gene_name": "Drd3", "organism": "Rat", "refseq_name": "D(3) dopamine receptor", "refseq_ac": [ { "id": "NP_058836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058836", "type": "external" } ], "gene_names_uniprotkb": "Drd3", "gene_names_refseq": "Drd3", "protein_names_uniprotkb": "D(3) dopamine receptor; Dopamine D3 receptor", "protein_names_refseq": "D(3) dopamine receptor; dopaminergic receptor D3", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); nicotine dependence (Disease Ontology:DOID:0050742); absence epilepsy (Disease Ontology:DOID:0070309); Parkinsonism (Disease Ontology:DOID:0080855); essential tremor 1 (Disease Ontology:DOID:0111428); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatitis (Disease Ontology:DOID:4989); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29238); (R-RNO-390651); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1358063;14499480;1975644;2039532;32646740;33249031;34508168;36638964;38917939;8333859", "class_list": "", "function": "Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Publication Status: Online-Only, [RefSeq, PubMed]; Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions. Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior. Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels. Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders. Promotes cell proliferation through MAP kinase signaling. Also involved in autophagy regulation: receptor activation stimulates AMPK, which phosphorylates RPTOR and enhances its interaction with MTOR, thereby inhibiting MTORC1 signaling and its downstream target RPS6KB1. This leads to activation of ULK1 and initiation of the autophagy cascade. Forms heterotetramers with DRD1 to potentiate beta-arrestin recruitment and mediate locomotor activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats., [RefSeq, PubMed]; Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia., [RefSeq, PubMed]; Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats., [RefSeq, PubMed]; Lentiviral-mediated up-regulation of let-7d microRNA decreases alcohol intake through down-regulating the dopamine D3 receptor., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P70647", "ec_number_list": [], "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0019904 protein domain specific binding;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0034776 response to histamine;GO:0046717 acid secretion;GO:0050709 negative regulation of protein secretion;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0060160 negative regulation of dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P19020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20789-1", "uniprot_id": [ { "id": "NTR1_RAT", "url": "https://www.uniprot.org/uniprot/P20789", "type": "external" } ], "mass": 47055.0, "length": 424, "protein_name": "Neurotensin receptor type 1", "gene_name": "Ntsr1", "organism": "Rat", "refseq_name": "neurotensin receptor type 1", "refseq_ac": [ { "id": "NP_001102437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102437", "type": "external" } ], "gene_names_uniprotkb": "Ntsr1; Ntsr", "gene_names_refseq": "Ntsr1; Ntsr", "protein_names_uniprotkb": "Neurotensin receptor type 1; High-affinity levocabastine-insensitive neurotensin receptor; NT-R-1; NTR1; NTRH", "protein_names_refseq": "NT-R-1; NTR1; NTRH; high-affinity levocabastine-insensitive neurotensin receptor; neurotensin receptor type 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Parkinson's disease (Disease Ontology:DOID:14330); opiate dependence (Disease Ontology:DOID:2559); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:366274); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1694443;23051748;24453215;26205105;28089664;29596791;32561375;34508168;38395391", "class_list": "", "function": "A thermostable variant termed enNTS1 exhibited the best combination of signaling capability and stability upon solubilization with detergents. Several well dispersed (13)CH3-methionine resonances were seen by solution NMR spectroscopy, many of which exhibited chemical shift changes upon the addition of the high affinity agonist peptide, NT8-13., [RefSeq, PubMed]; Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Neurotensin 1 receptor in the prelimbic cortex regulates anxiety-like behavior in rats., [RefSeq, PubMed]; Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling., [RefSeq, PubMed]; Study suggests that NTS1 and NTS2 neurotensin receptor mechanisms appear involved in fear conditioning processes and that agonists for neurotensin receptors may be pursued as novel anxiolytic drugs., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016492 G protein-coupled neurotensin receptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0001659 temperature homeostasis;GO:0006171 cAMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20789-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26801-1", "uniprot_id": [ { "id": "CEBPG_RAT", "url": "https://www.uniprot.org/uniprot/P26801", "type": "external" } ], "mass": 16388.0, "length": 150, "protein_name": "CCAAT/enhancer-binding protein gamma", "gene_name": "Cebpg", "organism": "Rat", "refseq_name": "CCAAT/enhancer-binding protein gamma", "refseq_ac": [ { "id": "NP_036963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036963", "type": "external" } ], "gene_names_uniprotkb": "Cebpg", "gene_names_refseq": "C/EBP; CEBPRNA; Cebpg", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein gamma; C/EBP gamma", "protein_names_refseq": "CCAAT/enhancer binding protein (C/EBP), gamma; CCAAT/enhancer-binding protein gamma; c/EBP gamma; homolog to a human CCAAT/enhancer binding protein - gamma", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000); lipid metabolism disorder (Disease Ontology:DOID:3146); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:25301)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12213809;12223092;1377818;16735515", "class_list": "", "function": "DNA binding activity of C/EBPbeta and C/EBPdelta for the rat alpha2-macroglobulin gene promoter is regulated in an acute-phase dependent manner, [RefSeq, PubMed]; Sumoylation of C/EBPalpha blocked its inhibitory effect on cell proliferation by leading to the disruption of a proliferation-inhibitory complex because of a failure of the sumoylated C/EBPalpha to interact with BRG1., [RefSeq, PubMed]; The C/EBP site and the enhancer binding proteins beta and gamma are involved in rat hepatic Class I ADH gene expression in vivo by ethanol, [RefSeq, PubMed]; Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending;GO:0003677 DNA binding;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0043353 enucleate erythrocyte differentiation;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26801-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47942-1", "uniprot_id": [ { "id": "DPYL2_RAT", "url": "https://www.uniprot.org/uniprot/P47942", "type": "external" } ], "mass": 62278.0, "length": 572, "protein_name": "Dihydropyrimidinase-related protein 2", "gene_name": "Dpysl2", "organism": "Rat", "refseq_name": "dihydropyrimidinase-related protein 2", "refseq_ac": [ { "id": "NP_001099187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099187", "type": "external" } ], "gene_names_uniprotkb": "Dpysl2", "gene_names_refseq": "Crmp2; Dpysl2; TOAD-64", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 2; CRMP-2; Collapsin response mediator protein 2; DRP-2; TOAD-64; Turned on after division 64 kDa protein", "protein_names_refseq": "CRMP-2; DRP-2; collapsin response mediator protein 2; dihydropyrimidinase-related protein 2; turned on after division, 64 kDa protein", "tax_id": 10116, "disease": "hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:25416); (R-RNO-399956); (R-RNO-437239)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10757975;11739622;15652488;16418269;17496889;18220421;19322778;22443207;22673903;27917413;31080913;32571373;34502162;34975828;35334412;36044155;37175950;38791516;38843836;7472434;9375656", "class_list": "", "function": "CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy., [RefSeq, PubMed]; Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; GSK3beta Interacts With CRMP2 and Notch1 and Controls T-Cell Motility. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy., [RefSeq, PubMed]; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006897 endocytosis;GO:0021510 spinal cord development;GO:0030154 cell differentiation;GO:0001975 response to amphetamine;GO:0014049 positive regulation of glutamate secretion", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P47942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50399-1", "uniprot_id": [ { "id": "GDIB_RAT", "url": "https://www.uniprot.org/uniprot/P50399", "type": "external" } ], "mass": 50537.0, "length": 445, "protein_name": "Rab GDP dissociation inhibitor beta", "gene_name": "Gdi2", "organism": "Rat", "refseq_name": "rab GDP dissociation inhibitor beta", "refseq_ac": [ { "id": "NP_058972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058972", "type": "external" } ], "gene_names_uniprotkb": "Gdi2; Gdi3", "gene_names_refseq": "Gdi2; Gdi3", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor beta; GDI-2; GDI-3; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta", "protein_names_refseq": "GDI-2; GDI-3; guanosine diphosphate (GDP) dissociation inhibitor 3; guanosine diphosphate dissociation inhibitor 2; guanosine diphosphate dissociation inhibitor 3; rab GDI beta; rab GDP dissociation inhibitor beta", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29662); (R-RNO-6798695); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;7779099;8188702", "class_list": "", "function": "GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P797", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005093 Rab GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:1903565 negative regulation of protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50399-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61169-1", "uniprot_id": [ { "id": "DRD2_RAT", "url": "https://www.uniprot.org/uniprot/P61169", "type": "external" } ], "mass": 50904.0, "length": 444, "protein_name": "D(2) dopamine receptor", "gene_name": "Drd2", "organism": "Rat", "refseq_name": "D(2) dopamine receptor isoform 1", "refseq_ac": [ { "id": "NP_036679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036679", "type": "external" } ], "gene_names_uniprotkb": "Drd2", "gene_names_refseq": "Drd2", "protein_names_uniprotkb": "D(2) dopamine receptor; Dopamine D2 receptor", "protein_names_refseq": "D(2) dopamine receptor isoform 1; d(2) dopamine receptor; dopamine receptor 2", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); migraine with aura (Disease Ontology:DOID:10024); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); anxiety disorder (Disease Ontology:DOID:2030); brain ischemia (Disease Ontology:DOID:2316); alcohol-induced mental disorder (Disease Ontology:DOID:251); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); toxic encephalopathy (Disease Ontology:DOID:3602); primary hyperaldosteronism (Disease Ontology:DOID:446); movement disease (Disease Ontology:DOID:480); schizophrenia (Disease Ontology:DOID:5419); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); end stage renal disease (Disease Ontology:DOID:783); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24318); (R-RNO-390651)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10391935;1321233;1358063;14499480;16049099;19332542;2137198;2137336;2138567;2139615;2480527;2531656;2531846;2531847;2974511;36638964;37208583;37956402;38554797", "class_list": "", "function": "Brain D2-Like Dopamine Receptor Distribution in Rats with Different Types of Genetic Epilepsy., [RefSeq, PubMed]; Dopamine receptor D2 regulates genes involved in germ cell movement and sperm motility in rat testesdagger., [RefSeq, PubMed]; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:1321233). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Dysregulation of striatal dopamine D2/D3 receptor-mediated by hypocretin induces depressive behaviors in rats., [RefSeq, PubMed]; Unveiling the therapeutic prospects of EGFR inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P13953", "ec_number_list": [], "go_molecular_function": "GO:0004952 dopamine neurotransmitter receptor activity;GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure;GO:0030432 peristalsis;GO:0031223 auditory behavior;GO:0021984 adenohypophysis development;GO:0034776 response to histamine", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P61169-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81062-1", "uniprot_id": [ { "id": "PITX3_RAT", "url": "https://www.uniprot.org/uniprot/P81062", "type": "external" } ], "mass": 31729.0, "length": 302, "protein_name": "Pituitary homeobox 3", "gene_name": "Pitx3", "organism": "Rat", "refseq_name": "pituitary homeobox 3", "refseq_ac": [ { "id": "NP_062120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062120", "type": "external" } ], "gene_names_uniprotkb": "Pitx3; Ptx3", "gene_names_refseq": "Pitx3", "protein_names_uniprotkb": "Pituitary homeobox 3; Homeobox protein PITX3; Paired-like homeodomain transcription factor 3", "protein_names_refseq": "homeobox protein PITX3; homeobox protein PTX3; paired-like homeodomain transcription factor 3; pituitary homeobox 3", "tax_id": 10116, "disease": "anterior segment dysgenesis (Disease Ontology:DOID:0060648); visual impairment and progressive phthisis bulbi (Disease Ontology:DOID:0070356); anterior segment dysgenesis 1 (Disease Ontology:DOID:0080606); cataract 11 multiple types (Disease Ontology:DOID:0110249); cataract 9 multiple types (Disease Ontology:DOID:0110266); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:29609)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;18951485;30634592;9371841", "class_list": "", "function": "A significant reduction in expression of the dopaminergic regulation factors Nurr1 and Pitx3 could not effectively regulate TH in the VTA during chronic morphine dependence, which affects the survival of dopaminergic neurons and ultimately leads to neuronal pathology. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0014014 negative regulation of gliogenesis;GO:1904935 positive regulation of cell proliferation in midbrain;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P81062-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7F5-1", "uniprot_id": [ { "id": "PIHD1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7F5", "type": "external" } ], "mass": 32361.0, "length": 290, "protein_name": "PIH1 domain-containing protein 1", "gene_name": "Pih1d1", "organism": "Rat", "refseq_name": "PIH1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001020039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020039", "type": "external" } ], "gene_names_uniprotkb": "Pih1d1", "gene_names_refseq": "Pih1d1; RGD1309809", "protein_names_uniprotkb": "PIH1 domain-containing protein 1", "protein_names_refseq": "PIH1 domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292898)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0051219 phosphoprotein binding;GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0097255 R2TP complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902661 positive regulation of glucose mediated signaling pathway;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V7F5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64350-1", "uniprot_id": [ { "id": "EI2BE_RAT", "url": "https://www.uniprot.org/uniprot/Q64350", "type": "external" } ], "mass": 80206.0, "length": 716, "protein_name": "Translation initiation factor eIF2B subunit epsilon", "gene_name": "Eif2b5", "organism": "Rat", "refseq_name": "translation initiation factor eIF2B subunit epsilon", "refseq_ac": [ { "id": "NP_620221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620221", "type": "external" } ], "gene_names_uniprotkb": "Eif2b5; Eif2be", "gene_names_refseq": "Eif2b5", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon", "protein_names_refseq": "eIF-2B GDP-GTP exchange factor subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon; eukaryotic translation initiation factor 2B subunit 5 epsilon; initiation factor eIF-2Be; translation initiation factor eIF-2B subunit epsilon; translation initiation factor eIF2B subunit epsilon", "tax_id": 10116, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 5 (Disease Ontology:DOID:0070367)", "pathway": " (rno:192234); (R-RNO-72731)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11311121;18556237;19023445;20484009;22673903;23707720;29393594;8688467", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB]; Data show that activation of mTORC1 is necessary and sufficient to stimulate eIF2Bepsilon mRNA translation., [RefSeq, PubMed]; Modulation of eIF2Bepsilon expression may be sufficient to correct deficits in skeletal muscle protein synthesis associated with sepsis and other muscle-wasting conditions, [RefSeq, PubMed]; Oligodendroglial-derived cells expressing a mutated eIF2B5 constantly use their stress response mechanism as an adaptation mean in order to survive, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKL3", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0002183 cytoplasmic translational initiation;GO:0043065 positive regulation of apoptotic process;GO:0021766 hippocampus development;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64350-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF9-1", "uniprot_id": [ { "id": "IIGP5_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF9", "type": "external" } ], "mass": 50556.0, "length": 463, "protein_name": "Interferon-inducible GTPase 5", "gene_name": "Irgc", "organism": "Rat", "refseq_name": "interferon-inducible GTPase 5", "refseq_ac": [ { "id": "NP_001014038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014038", "type": "external" } ], "gene_names_uniprotkb": "Irgc; Iigp5; Irgc1", "gene_names_refseq": "Ifgge; Irgc1; Irgc; RGD1311107", "protein_names_uniprotkb": "Interferon-inducible GTPase 5; 3.6.5.-; Immunity-related GTPase cinema 1", "protein_names_refseq": "immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon-gamma-inducible GTPase Ifgge protein; interferon-inducible GTPase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:308428)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21454685;22673903", "class_list": "", "function": "GTPase required for sperm motility and therefore male fertility, via positive regulation of spermatozoa fibrous sheath formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005811 lipid droplet;GO:0016020 membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:1902093 positive regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYM0-1", "uniprot_id": [ { "id": "SMIP4_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYM0", "type": "external" } ], "mass": 67983.0, "length": 588, "protein_name": "Sperm-associated microtubule inner protein 4", "gene_name": "Spmip4", "organism": "Rat", "refseq_name": "sperm-associated microtubule inner protein 4", "refseq_ac": [ { "id": "NP_001019500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019500", "type": "external" } ], "gene_names_uniprotkb": "Spmip4", "gene_names_refseq": "Spmip4", "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 4", "protein_names_refseq": "sperm associated microtubule inner protein 4; sperm-associated microtubule inner protein 4; uncharacterized protein C7orf31 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500124)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EV70-1", "uniprot_id": [ { "id": "OFUT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6EV70", "type": "external" } ], "mass": 44983.0, "length": 395, "protein_name": "GDP-fucose protein O-fucosyltransferase 1", "gene_name": "Pofut1", "organism": "Rat", "refseq_name": "GDP-fucose protein O-fucosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_001002278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002278", "type": "external" } ], "gene_names_uniprotkb": "Pofut1; Fut12", "gene_names_refseq": "Fut12; O-FucT-1; Pofut1", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase 1; 2.4.1.221; O-FucT-1; Peptide-O-fucosyltransferase 1", "protein_names_refseq": "GDP-fucose protein O-fucosyltransferase 1 precursor; GDP-fucose protein O-fucosyltransferase 1; peptide-O-fucosyltransferase 1", "tax_id": 10116, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256)", "pathway": " (rno:311551)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12966037;15653671;9023546", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs) (By similarity). Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0007507 heart development;GO:0001756 somitogenesis", "synthesized_glycan_count": 158, "hit_score": 0.4, "record_id": "Q6EV70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6U0-1", "uniprot_id": [ { "id": "FGR_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6U0", "type": "external" } ], "mass": 58821.0, "length": 517, "protein_name": "Tyrosine-protein kinase Fgr", "gene_name": "Fgr", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Fgr", "refseq_ac": [ { "id": "NP_077059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077059", "type": "external" } ], "gene_names_uniprotkb": "Fgr", "gene_names_refseq": "Fgr; p55-Fgr", "protein_names_uniprotkb": "Tyrosine-protein kinase Fgr; 2.7.10.2; Proto-oncogene c-Fgr; p55-Fgr", "protein_names_refseq": "Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; feline Gardner-Rasheed sarcoma viral oncogene; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase Fgr; tyrosine-protein kinase Fgr", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:79113); (R-RNO-2029481); (R-RNO-432142); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10066823;15282299;18247338;21746961;22673903;29393594;30352950;7515063;8611520;9183008", "class_list": "", "function": "Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation Publication Status: Online-Only, [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63206", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P6U0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSN4-1", "uniprot_id": [ { "id": "PIGW_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSN4", "type": "external" } ], "mass": 56443.0, "length": 502, "protein_name": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW", "gene_name": "Pigw", "organism": "Rat", "refseq_name": "glucosaminyl-phosphatidylinositol- acyltransferase PIGW", "refseq_ac": [ { "id": "NP_919443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_919443", "type": "external" } ], "gene_names_uniprotkb": "Pigw; Znhit3", "gene_names_refseq": "Pigw", "protein_names_uniprotkb": "Glucosaminyl-phosphatidylinositol-acyltransferase PIGW; 2.3.-.-; GlcN-PI-acyltransferase; PIG-W; Phosphatidylinositol-glycan biosynthesis class W protein", "protein_names_refseq": "PIG-W; glcN-PI-acyltransferase; glucosaminyl-phosphatidylinositol- acyltransferase PIGW; phosphatidylinositol glycan, class W; phosphatidylinositol-glycan biosynthesis class W protein", "tax_id": 10116, "disease": "hyperphosphatasia with impaired intellectual development syndrome 5 (Disease Ontology:DOID:0070432); PEHO syndrome (Disease Ontology:DOID:0080539)", "pathway": " (rno:378774); (R-RNO-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14517336;22673903", "class_list": "", "function": "A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor., [UniProtKB, UniProtKB]; Acyltransferase that catalyzes the acyl transfer from an acyl-CoA at the 2-OH position of the inositol ring of a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl phosphatidylinositol, GlcN-PI) to generate a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) and participates in the fourth step of GPI-anchor biosynthesis (PubMed:14517336). Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Acylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (PubMed:14517336)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7TSN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQC9-1", "uniprot_id": [ { "id": "CXXC4_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQC9", "type": "external" } ], "mass": 20978.0, "length": 198, "protein_name": "CXXC-type zinc finger protein 4", "gene_name": "Cxxc4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cxxc4; Idax", "gene_names_refseq": "", "protein_names_uniprotkb": "CXXC-type zinc finger protein 4; Inhibition of the Dvl and axin complex protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11113207;15313210", "class_list": "", "function": "Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding;GO:0008327 methyl-CpG binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQC9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07647-1", "uniprot_id": [ { "id": "GTR3_RAT", "url": "https://www.uniprot.org/uniprot/Q07647", "type": "external" } ], "mass": 53581.0, "length": 493, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 3", "gene_name": "Slc2a3", "organism": "Rat", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 3 isoform 1", "refseq_ac": [ { "id": "NP_058798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058798", "type": "external" } ], "gene_names_uniprotkb": "Slc2a3; Glut3", "gene_names_refseq": "GLUT3; Slc2a3", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; Glucose transporter type 3, brain", "protein_names_refseq": "GLUT-3; Solute carrier family 2 A3 (neuron glucose transporter); glucose transporter type 3, brain; solute carrier family 2 (facilitated glucose transporter), member 3; solute carrier family 2, facilitated glucose transporter member 3 isoform 1; solute carrier family 2, facilitated glucose transporter member 3-like; solute carrier family 2, member 2", "tax_id": 10116, "disease": "progressive familial intrahepatic cholestasis 1 (Disease Ontology:DOID:0070226); intrahepatic cholestasis of pregnancy 1 (Disease Ontology:DOID:0070228); benign recurrent intrahepatic cholestasis 1 (Disease Ontology:DOID:0070231); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); intrahepatic cholestasis (Disease Ontology:DOID:1852); acanthosis nigricans (Disease Ontology:DOID:3138); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25551); (R-RNO-189200); (R-RNO-196836); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "21076856;22673903;24995978;29582588;30296507;33856052;7475896;8243635", "class_list": "", "function": "Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport., [UniProtKB, UniProtKB, UniProtKB]; Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings show that age alters glucose uptake and GLUT3/4 expression profiles before and after Spinal Cord Injury., [RefSeq, PubMed]; Fructose-rich diet and walnut supplementation differently regulate rat hypothalamic and hippocampal glucose transporters expression., [RefSeq, PubMed]; Study found no differences in mRNA or protein levels of neuronal monocarboxylate transporters (MCTs). Functional analyses revealed that neuronal MCT2 had high catalytic efficiency in Huntington's disease (HD) cells. Ascorbic acid did not stimulate lactate uptake in HD cells; and was unable to inhibit glucose transport in HD cells because they exhibit decreased expression of the neuronal glucose transporter GLUT3., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62729", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0019900 kinase binding;GO:0016936 galactoside binding;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043204 perikaryon", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0043066 negative regulation of apoptotic process;GO:0021987 cerebral cortex development;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07647-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42346-1", "uniprot_id": [ { "id": "MTOR_RAT", "url": "https://www.uniprot.org/uniprot/P42346", "type": "external" } ], "mass": 288794.0, "length": 2549, "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "Mtor", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase mTOR", "refseq_ac": [ { "id": "NP_063971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063971", "type": "external" } ], "gene_names_uniprotkb": "Mtor; Frap1; Raft1", "gene_names_refseq": "Frap1; Mtor; RAFT1", "protein_names_uniprotkb": "Serine/threonine-protein kinase mTOR; 2.7.10.2; 2.7.11.1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; Mechanistic target of rapamycin; RAPT1; Rapamycin target protein 1; Tyrosine-protein kinase mTOR; mTOR", "protein_names_refseq": "FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; RAPT1; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); rapamycin and FKBP12 target-1 protein; rapamycin target protein 1; serine/threonine-protein kinase mTOR; tyrosine-protein kinase mTOR", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); crescentic glomerulonephritis (Disease Ontology:DOID:13139); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); chondrosarcoma (Disease Ontology:DOID:3371); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); kidney angiomyolipoma (Disease Ontology:DOID:8411); vascular dementia (Disease Ontology:DOID:8725); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:56718); (R-RNO-1257604); (R-RNO-1632852); (R-RNO-165159); (R-RNO-166208); (R-RNO-3371571); (R-RNO-380972); (R-RNO-389357); (R-RNO-5218920); (R-RNO-5628897); (R-RNO-6804757); (R-RNO-8943724); (R-RNO-9639288); (R-RNO-9856530)", "pathway_count": 14, "publication_count": 58, "publication_id_list": "15479767;16627569;17283241;18028531;18262357;19169352;20175208;20368999;21368105;21427787;21576368;21720156;21750711;22238580;22242130;22673903;22927967;23456824;23598645;23681769;24187137;24204984;24333331;24393531;24694942;24833464;25339866;25474550;25539833;26121129;27004051;27057269;27096004;27405707;27660271;27903964;28252052;28296942;28572610;29722337;30678506;31426858;31692643;31885498;32341448;32532964;32549974;33256214;33716957;33732083;38523410;38622478;38871197;39120751;39236462;7518356;7822316;9465032", "class_list": "", "function": "BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage., [RefSeq, PubMed]; Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway., [RefSeq, PubMed]; Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway., [RefSeq, PubMed]; Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals (By similarity). MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins (By similarity). Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2) (By similarity). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (By similarity). This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E) (By similarity). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4 (PubMed:9465032). Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex (By similarity). Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor (By similarity). Activates dormant ribosomes by mediating phosphorylation of SERBP1, leading to SERBP1 inactivation and reactivation of translation (By similarity). In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1 (By similarity). To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A (By similarity). In the same time, mTORC1 inhibits catabolic pathways: negatively regulates autophagy through phosphorylation of ULK1 (By similarity). Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1 (By similarity). Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP (By similarity). Also prevents autophagy by phosphorylating RUBCNL/Pacer under nutrient-rich conditions (By similarity). Prevents autophagy by mediating phosphorylation of AMBRA1, thereby inhibiting AMBRA1 ability to mediate ubiquitination of ULK1 and interaction between AMBRA1 and PPP2CA (By similarity). mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor (By similarity). Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules (By similarity). The mTORC1 complex is inhibited in response to starvation and amino acid depletion (By similarity). The non-canonical mTORC1 complex, which acts independently of RHEB, specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3 in the presence of nutrients, promoting their cytosolic retention and inactivation (By similarity). Upon starvation or lysosomal stress, inhibition of mTORC1 induces dephosphorylation and nuclear translocation of TFEB and TFE3, promoting their transcription factor activity (By similarity). The mTORC1 complex regulates pyroptosis in macrophages by promoting GSDMD oligomerization (By similarity). MTOR phosphorylates RPTOR which in turn inhibits mTORC1 (By similarity). As part of the mTORC2 complex, MTOR transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (By similarity). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (By similarity). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (By similarity). mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422' (By similarity). mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). May also regulate insulin signaling by acting as a tyrosine protein kinase that catalyzes phosphorylation of IGF1R and INSR (By similarity). Regulates osteoclastogenesis by adjusting the expression of CEBPB isoforms (By similarity). Plays an important regulatory role in the circadian clock function; regulates period length and rhythm amplitude of the suprachiasmatic nucleus (SCN) and liver clocks (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0050882 voluntary musculoskeletal movement;GO:1904059 regulation of locomotor rhythm;GO:0055006 cardiac cell development", "synthesized_glycan_count": 0, "hit_score": 5.9, "record_id": "P42346-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MPA9-1", "uniprot_id": [ { "id": "DCLK2_RAT", "url": "https://www.uniprot.org/uniprot/Q5MPA9", "type": "external" } ], "mass": 84016.0, "length": 767, "protein_name": "Serine/threonine-protein kinase DCLK2", "gene_name": "Dclk2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase DCLK2 isoform b", "refseq_ac": [ { "id": "NP_001009691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009691", "type": "external" } ], "gene_names_uniprotkb": "Dclk2; Dcamkl2; Dck2", "gene_names_refseq": "CL2; CLICK-II; CLICK2; Dck2; Dclk2; RGD1308384", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK2; 2.7.11.1; CL2; CLICK-II; CLICK2; CaMK-like CREB regulatory kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2", "protein_names_refseq": "caMK-like CREB regulatory kinase 2; doublecortin kinase 2; doublecortin-like and CAM kinase-like 2; serine/threonine-protein kinase DCLK2 isoform b; serine/threonine-protein kinase DCLK2", "tax_id": 10116, "disease": "dyslexia (Disease Ontology:DOID:4428)", "pathway": " (rno:310698)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15611072;16641100;38843836", "class_list": "", "function": "Doublecortin kinase-2 is associated with terminal segments of axons and dendrites, [RefSeq, PubMed]; Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that this gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5MPA7;Q5MPA8;Q5MPB0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1900181 negative regulation of protein localization to nucleus;GO:0021766 hippocampus development;GO:0034504 protein localization to nucleus;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5MPA9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88450-1", "uniprot_id": [ { "id": "DEAF1_RAT", "url": "https://www.uniprot.org/uniprot/O88450", "type": "external" } ], "mass": 59532.0, "length": 565, "protein_name": "Deformed epidermal autoregulatory factor 1 homolog", "gene_name": "Deaf1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Deaf1; Spn", "gene_names_refseq": "", "protein_names_uniprotkb": "Deformed epidermal autoregulatory factor 1 homolog; NUDR; Nuclear DEAF-1-related transcriptional regulator; Suppressin", "protein_names_refseq": "", "tax_id": 10116, "disease": "Vulto-van Silfout-de Vries syndrome (Disease Ontology:DOID:0070054)", "pathway": " (rno:83632)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;22673903;9417089;9773984", "class_list": "", "function": "Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Transcriptional activator of EIF4G3. May also involved in behavior (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62998", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008542 visual learning;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88450-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6Q2-1", "uniprot_id": [ { "id": "K2C5_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6Q2", "type": "external" } ], "mass": 61826.0, "length": 576, "protein_name": "Keratin, type II cytoskeletal 5", "gene_name": "Krt5", "organism": "Rat", "refseq_name": "keratin, type II cytoskeletal 5", "refseq_ac": [ { "id": "NP_899162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899162", "type": "external" } ], "gene_names_uniprotkb": "Krt5; Krt2-5", "gene_names_refseq": "CK-5; K5; Krt2-5; Krt5; Sak57", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 5; CK-5; Cytokeratin-5; K5; Keratin-5; Type-II keratin Kb5", "protein_names_refseq": "cytokeratin-5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 8; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5; type-II keratin Kb5", "tax_id": 10116, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256); generalized severe epidermolysis bullosa simplex 1A (Disease Ontology:DOID:0060735); epidermolysis bullosa simplex 2F with mottled pigmentation (Disease Ontology:DOID:0111346); urinary bladder cancer (Disease Ontology:DOID:11054); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (rno:369017); (R-RNO-446107); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12882830;14551252;22673903;34502162;38843836", "class_list": "", "function": "Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes., [UniProtKB, UniProtKB]; Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Together with its obligate type I partner KRT14, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN97", "ec_number_list": [], "go_molecular_function": "GO:0097110 scaffold protein binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005882 intermediate filament;GO:0001533 cornified envelope;GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0009612 response to mechanical stimulus;GO:0032880 regulation of protein localization;GO:0030334 regulation of cell migration;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6P6Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Q0-1", "uniprot_id": [ { "id": "DEN5A_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Q0", "type": "external" } ], "mass": 146637.0, "length": 1287, "protein_name": "DENN domain-containing protein 5A", "gene_name": "Dennd5a", "organism": "Rat", "refseq_name": "DENN domain-containing protein 5A", "refseq_ac": [ { "id": "NP_001101016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101016", "type": "external" } ], "gene_names_uniprotkb": "Dennd5a", "gene_names_refseq": "Dennd5a; Rab6ip1", "protein_names_uniprotkb": "DENN domain-containing protein 5A; Rab6-interacting protein 1; Rab6IP1", "protein_names_refseq": "DENN domain-containing protein 5A; DENN/MADD domain containing 5A; Rab6 interacting protein 1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 49 (Disease Ontology:DOID:0080441)", "pathway": " (rno:308942); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27866705", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (PubMed:27866705)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030904 retromer complex", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V7Q0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESW0-1", "uniprot_id": [ { "id": "DDB1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESW0", "type": "external" } ], "mass": 126862.0, "length": 1140, "protein_name": "DNA damage-binding protein 1", "gene_name": "Ddb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddb1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA damage-binding protein 1; Damage-specific DNA-binding protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); communication disorder (Disease Ontology:DOID:2033)", "pathway": " (rno:64470); (R-RNO-110314); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-8951664)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock., [UniProtKB, UniProtKB, UniProtKB]; Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (By similarity). DDB1-mediated CRY1 degradation promotes FOXO1 protein stability and FOXO1-mediated gluconeogenesis in the liver (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (By similarity). Maternal factor required for proper zygotic genome activation and genome reprogramming (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003684 damaged DNA binding;GO:0044877 protein-containing complex binding;GO:0097602 cullin family protein binding;GO:0071987 WD40-repeat domain binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0000109 nucleotide-excision repair complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0051702 biological process involved in interaction with symbiont;GO:0046726 positive regulation by virus of viral protein levels in host cell;GO:0006281 DNA repair;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ESW0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESI7-1", "uniprot_id": [ { "id": "DCX_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESI7", "type": "external" } ], "mass": 40560.0, "length": 365, "protein_name": "Neuronal migration protein doublecortin", "gene_name": "Dcx", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dcx", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal migration protein doublecortin", "protein_names_refseq": "", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); subcortical band heterotopia (Disease Ontology:DOID:0111169); X-linked lissencephaly 1 (Disease Ontology:DOID:0112239); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); brain infarction (Disease Ontology:DOID:3454); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:84394)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14741102;22673903;38843836", "class_list": "", "function": "Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0021510 spinal cord development;GO:0035556 intracellular signal transduction;GO:0001764 neuron migration;GO:0021766 hippocampus development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESI7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04041-1", "uniprot_id": [ { "id": "GPX1_RAT", "url": "https://www.uniprot.org/uniprot/P04041", "type": "external" } ], "mass": 22305.0, "length": 201, "protein_name": "Glutathione peroxidase 1", "gene_name": "Gpx1", "organism": "Rat", "refseq_name": "glutathione peroxidase 1", "refseq_ac": [ { "id": "NP_110453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110453", "type": "external" } ], "gene_names_uniprotkb": "Gpx1", "gene_names_refseq": "GSHPx-1; GSHPx; Gpx1", "protein_names_uniprotkb": "Glutathione peroxidase 1; 1.11.1.12; 1.11.1.9; Cellular glutathione peroxidase; GPx-1; GSHPx-1; Phospholipid-hydroperoxide glutathione peroxidase GPX1", "protein_names_refseq": "GPx-1; cellular glutathione peroxidase; glutathione peroxidase 1; phospholipid-hydroperoxide glutathione peroxidase GPX1", "tax_id": 10116, "disease": "Keshan disease (Disease Ontology:DOID:0050083); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); myeloid neoplasm (Disease Ontology:DOID:0070004); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); alpha thalassemia (Disease Ontology:DOID:1099); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); iron deficiency anemia (Disease Ontology:DOID:11758); nephrotic syndrome (Disease Ontology:DOID:1184); leukemia (Disease Ontology:DOID:1240); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); calcinosis (Disease Ontology:DOID:182); colon cancer (Disease Ontology:DOID:219); anemia (Disease Ontology:DOID:2355); nephrosis (Disease Ontology:DOID:2527); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); hairy cell leukemia (Disease Ontology:DOID:285); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); coronary artery disease (Disease Ontology:DOID:3393); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); ulcerative colitis (Disease Ontology:DOID:8577); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24404); (R-RNO-2142712); (R-RNO-2142770); (R-RNO-3299685)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "1451786;1640255;19944066;22673903;2838821;3387231;3408482;34502162;35968584;36868433;37761814;6217842", "class_list": "", "function": "Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway., [UniProtKB, UniProtKB]; Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns. Publication Status: Online-Only, [RefSeq, PubMed]; Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway., [RefSeq, PubMed]; Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway., [RefSeq, PubMed]; The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 49, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08946;Q4PIY2;Q91WZ5", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:1990782 protein tyrosine kinase binding;GO:0004601 peroxidase activity;GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0097413 Lewy body", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0051702 biological process involved in interaction with symbiont;GO:0009609 response to symbiotic bacterium;GO:0001659 temperature homeostasis;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P04041-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02680-1", "uniprot_id": [ { "id": "FIBG_RAT", "url": "https://www.uniprot.org/uniprot/P02680", "type": "external" } ], "mass": 50633.0, "length": 445, "protein_name": "Fibrinogen gamma chain", "gene_name": "Fgg", "organism": "Rat", "refseq_name": "fibrinogen gamma chain precursor", "refseq_ac": [ { "id": "NP_036691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036691", "type": "external" } ], "gene_names_uniprotkb": "Fgg", "gene_names_refseq": "Fgg", "protein_names_uniprotkb": "Fibrinogen gamma chain", "protein_names_refseq": "fibrinogen gamma chain precursor; fibrinogen, gamma polypeptide", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); brain small vessel disease (Disease Ontology:DOID:0112313); congenital afibrinogenemia (Disease Ontology:DOID:2236); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); multiple myeloma (Disease Ontology:DOID:9538); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24367); (R-RNO-114608); (R-RNO-216083); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-381426); (R-RNO-5674135); (R-RNO-5686938); (R-RNO-8957275); (R-RNO-9769733)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "21454685;22673903;34502162;3562236;6232608;6897622", "class_list": "", "function": "Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68FY3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0045202 synapse", "go_biological_process": "GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion;GO:0050714 positive regulation of protein secretion;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06399-1", "uniprot_id": [ { "id": "FIBA_RAT", "url": "https://www.uniprot.org/uniprot/P06399", "type": "external" } ], "mass": 86686.0, "length": 782, "protein_name": "Fibrinogen alpha chain", "gene_name": "Fga", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fga", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrinogen alpha chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary systemic amyloidosis 2 (Disease Ontology:DOID:0050636); brain small vessel disease (Disease Ontology:DOID:0112313); keratoconus (Disease Ontology:DOID:10126); disseminated intravascular coagulation (Disease Ontology:DOID:11247); thrombocytopenia (Disease Ontology:DOID:1588); congenital afibrinogenemia (Disease Ontology:DOID:2236); brain ischemia (Disease Ontology:DOID:2316); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); holoprosencephaly (Disease Ontology:DOID:4621); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); Barrett's adenocarcinoma (Disease Ontology:DOID:7941); Crohn's disease (Disease Ontology:DOID:8778); actinic keratosis (Disease Ontology:DOID:8866); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:361969); (R-RNO-114608); (R-RNO-216083); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-381426); (R-RNO-5674135); (R-RNO-5686938); (R-RNO-8957275); (R-RNO-9769733)", "pathway_count": 11, "publication_count": 6, "publication_id_list": "21454685;22673903;34502162;3817019;4046033;8595905", "class_list": "", "function": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0045202 synapse", "go_biological_process": "GO:0045087 innate immune response;GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006953 acute-phase response;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06399-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GF25-1", "uniprot_id": [ { "id": "MANEA_RAT", "url": "https://www.uniprot.org/uniprot/Q5GF25", "type": "external" } ], "mass": 53416.0, "length": 462, "protein_name": "Glycoprotein endo-alpha-1,2-mannosidase", "gene_name": "Manea", "organism": "Rat", "refseq_name": "glycoprotein endo-alpha-1,2-mannosidase", "refseq_ac": [ { "id": "NP_542963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542963", "type": "external" } ], "gene_names_uniprotkb": "Manea", "gene_names_refseq": "Enman; Manea", "protein_names_uniprotkb": "Glycoprotein endo-alpha-1,2-mannosidase; 3.2.1.130; Endo-alpha mannosidase; Endo-alpha-D-mannosidase; Endomannosidase; Enman; rEndo", "protein_names_refseq": "endo-alpha mannosidase; endo-alpha-D-mannosidase; endomannosidase; glycoprotein endo-alpha-1,2-mannosidase; rEndo", "tax_id": 10116, "disease": "anxiety disorder (Disease Ontology:DOID:2030); panic disorder (Disease Ontology:DOID:594); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:140808); (R-RNO-964739)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15677381;16871372;18425413;9361017", "class_list": "glycogene;glycosylhydrolase", "function": "Endomannosidase does not discriminate the folding state og substrate and provides a back-up mechanism for completion of N-glycosylation of endoplasmic reticulum-escaped glucosylated glycoproteins., [RefSeq, PubMed]; The presence of positively charged amino acids in the cytoplasmic tail is critical for Golgi localization of rat endomannosidase., [RefSeq, PubMed]; We have cloned two novel endomannosidase sequences from rat and human cDNA libraries [and] confirm that endomannosidase is a type II membrane protein, like the majority of other secretory pathway glycosylation enzymes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35390", "ec_number_list": [ { "id": "3.2.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.130", "type": "external" } ], "go_molecular_function": "GO:0004559 alpha-mannosidase activity;GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5GF25-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHX9-1", "uniprot_id": [ { "id": "MTL5_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHX9", "type": "external" } ], "mass": 50469.0, "length": 475, "protein_name": "Tesmin", "gene_name": "Tesmin", "organism": "Rat", "refseq_name": "tesmin", "refseq_ac": [ { "id": "NP_001012069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012069", "type": "external" } ], "gene_names_uniprotkb": "Tesmin; Mtl5", "gene_names_refseq": "Mtl5; Tesmin", "protein_names_uniprotkb": "Tesmin; Metallothionein-like 5, testis-specific", "protein_names_refseq": "metallothionein-like 5, testis-specific (tesmin); tesmin", "tax_id": 10116, "disease": "", "pathway": " (rno:309142)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May have a role in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5YLM1-1", "uniprot_id": [ { "id": "DGLA_RAT", "url": "https://www.uniprot.org/uniprot/Q5YLM1", "type": "external" } ], "mass": 115301.0, "length": 1044, "protein_name": "Diacylglycerol lipase-alpha", "gene_name": "Dagla", "organism": "Rat", "refseq_name": "diacylglycerol lipase-alpha", "refseq_ac": [ { "id": "NP_001005886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005886", "type": "external" } ], "gene_names_uniprotkb": "Dagla; Nsddr", "gene_names_refseq": "Dagla; Nsddr", "protein_names_uniprotkb": "Diacylglycerol lipase-alpha; 3.1.1.116; DGL-alpha; Neural stem cell-derived dendrite regulator; Sn1-specific diacylglycerol lipase alpha", "protein_names_refseq": "DGL-alpha; diacylglycerol lipase-alpha; neural stem cell-derived dendrite regulator; sn1-specific diacylglycerol lipase alpha", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:309207); (R-RNO-426048)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18247369;20599824;22673903;34544759", "class_list": "", "function": "CaMKII Modulates Diacylglycerol Lipase-alpha Activity in the Rat Nucleus Accumbens after Incubation of Cocaine Craving. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that L- and N-type calcium channel current, but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity., [RefSeq, PubMed]; Maternal deprivation induced a significant increase in DAGLalpha immunoreactivity in the rat both males and females., [RefSeq, PubMed]; Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the CNS. Controls the activity of 2-AG as a retrograde messenger at neuronal synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0031901 early endosome membrane;GO:0032590 dendrite membrane;GO:0043196 varicosity", "go_biological_process": "GO:0071926 endocannabinoid signaling pathway;GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:0045471 response to ethanol;GO:0046340 diacylglycerol catabolic process;GO:0007405 neuroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5YLM1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63269-1", "uniprot_id": [ { "id": "ITPR3_RAT", "url": "https://www.uniprot.org/uniprot/Q63269", "type": "external" } ], "mass": 304286.0, "length": 2670, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3", "gene_name": "Itpr3", "organism": "Rat", "refseq_name": "inositol 1,4,5-trisphosphate-gated calcium channel ITPR3", "refseq_ac": [ { "id": "NP_037270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037270", "type": "external" } ], "gene_names_uniprotkb": "Itpr3", "gene_names_refseq": "IP3R-3; IP3R3X; IP3R3; Itpr3", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; IP3 receptor isoform 3; IP3R-3; Inositol 1,4,5-trisphosphate receptor type 3; InsP3R3; Type 3 InsP3 receptor; Type 3 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "IP3 receptor; IP3R 3; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; type 3 InsP3 receptor; type 3 inositol 1,4,5-trisphosphate receptor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); immunodeficiency 133 (Disease Ontology:DOID:0061096); pre-eclampsia (Disease Ontology:DOID:10591); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25679); (R-RNO-114508); (R-RNO-139853); (R-RNO-381676); (R-RNO-5578775); (R-RNO-9717207); (R-RNO-983695)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11149946;11163362;12032348;21383013;22673903;23884412;24469450;25242084;25482245;8388391", "class_list": "", "function": "An age-related decline in IP3R3 expression and NPY signaling underlie age-related homeostatic changes and olfactory dysfunction., [RefSeq, PubMed]; Inositol 1,4,5-trisphosphate-gated calcium channel that, upon 1D-myo-inositol 1,4,5-trisphosphate binding, transports calcium from the endoplasmic reticulum lumen to cytoplasm, thus releasing the intracellular calcium and therefore participates in cellular calcium ion homeostasis (By similarity). 11D-myo-inositol 1,4,5-trisphosphate binds to the ligand-free channel without altering its global conformation, yielding the low-energy resting state, then progresses through resting-to preactivated transitions to the higher energy preactivated state, which increases affinity for calcium, promoting binding of the low basal cytosolic calcium at the juxtamembrane domain (JD) site, favoring the transition through the ensemble of high-energy intermediate states along the trajectory to the fully-open activated state (By similarity). Upon opening, releases calcium in the cytosol where it can bind to the low-affinity cytoplasmic domain (CD) site and stabilizes the inhibited state to terminate calcium release (By similarity)., [UniProtKB, UniProtKB]; It regulates calcium transients in neonatal rat ventricular myocytes.(37-46), [RefSeq, PubMed]; Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3R3., [RefSeq, PubMed]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007613 memory;GO:0051289 protein homotetramerization;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q63269-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY06-1", "uniprot_id": [ { "id": "IZUM1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY06", "type": "external" } ], "mass": 43579.0, "length": 383, "protein_name": "Izumo sperm-egg fusion protein 1", "gene_name": "Izumo1", "organism": "Rat", "refseq_name": "izumo sperm-egg fusion protein 1 precursor", "refseq_ac": [ { "id": "NP_001017514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017514", "type": "external" } ], "gene_names_uniprotkb": "Izumo1", "gene_names_refseq": "Izumo1", "protein_names_uniprotkb": "Izumo sperm-egg fusion protein 1; OBF; Oocyte binding/fusion factor; Sperm-specific protein izumo", "protein_names_refseq": "OBF; izumo sperm-egg fusion 1; izumo sperm-egg fusion protein 1 precursor; izumo sperm-egg fusion protein 1; oocyte binding/fusion factor; sperm-specific protein izumo", "tax_id": 10116, "disease": "", "pathway": " (rno:499152); (R-RNO-1300645)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15759005;19658160;22673903;35096839;37951137", "class_list": "", "function": "Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen' (By similarity). Plays a critical role in sperm-oolemma binding prior to plasma membrane fusion (PubMed:35096839). Can mediate cell-cell fusion in cultured mammalian cells independently of its binding to IZUMO1R/JUNO (By similarity)., [UniProtKB, UniProtKB, PubMed]; Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048018 receptor ligand activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0035036 sperm-egg recognition;GO:0000768 syncytium formation by plasma membrane fusion;GO:0007339 binding of sperm to zona pellucida;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AY06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10688-1", "uniprot_id": [ { "id": "PLCD1_RAT", "url": "https://www.uniprot.org/uniprot/P10688", "type": "external" } ], "mass": 85962.0, "length": 756, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "gene_name": "Plcd1", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1", "refseq_ac": [ { "id": "NP_058731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058731", "type": "external" } ], "gene_names_uniprotkb": "Plcd1", "gene_names_refseq": "Plc1; Plcd1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 3.1.4.11; PLC-III; PLC-delta-1; Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; Phospholipase C-delta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-III; PLC-delta-1; Phospholipase C-delta1; phosphoinositide phospholipase C-delta-1; phosphoinositide phospholipase C; phospholipase C delta 1 long form; phospholipase C-III", "tax_id": 10116, "disease": "nonsyndromic congenital nail disorder 3 (Disease Ontology:DOID:0080081); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:24655); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "11706040;12054611;1313009;16000311;1684614;22710061;24098488;24235144;24810051;27783455;3390863;8521504;8602259;8784353;9062102;9565585", "class_list": "", "function": "Ca2+-independent binding of anionic phospholipids by phospholipase C delta1 EF-hand domain., [RefSeq, PubMed]; Data suggest that these phospholipase C delta-1 (PLCdelta1) mutations associated with hereditary leukonychia do not uniformly alter the enzymatic ability of this protein leading to loss/gain of function, but result in significantly divergent enzymatic properties., [RefSeq, PubMed]; Phospholipase C delta 1 regulates interleukin-1beta and tumor necrosis factor-alpha mRNA expression., [RefSeq, PubMed]; Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function. Publication Status: Online-Only, [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:16000311). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q80WI4;Q9QVD3;Q9QVD4;Q9QVD5", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005543 phospholipid binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0010701 positive regulation of norepinephrine secretion;GO:0001525 angiogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10688-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15127-1", "uniprot_id": [ { "id": "INSR_RAT", "url": "https://www.uniprot.org/uniprot/P15127", "type": "external" } ], "mass": 156757.0, "length": 1383, "protein_name": "Insulin receptor", "gene_name": "Insr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Insr", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin receptor; 2.7.10.1; IR", "protein_names_refseq": "", "tax_id": 10116, "disease": "Donohue syndrome (Disease Ontology:DOID:0050470); alcohol dependence (Disease Ontology:DOID:0050741); pre-malignant neoplasm (Disease Ontology:DOID:0060071); familial hyperinsulinemic hypoglycemia 5 (Disease Ontology:DOID:0070220); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); orofacial cleft 15 (Disease Ontology:DOID:0080408); short bowel syndrome (Disease Ontology:DOID:10605); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); hepatic encephalopathy (Disease Ontology:DOID:13413); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); choriocarcinoma (Disease Ontology:DOID:3594); glucose metabolism disease (Disease Ontology:DOID:4194); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); sleep disorder (Disease Ontology:DOID:535); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24954); (R-RNO-6811558); (R-RNO-74713); (R-RNO-74749); (R-RNO-74751); (R-RNO-74752); (R-RNO-77387)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "10803466;16803852;19778377;21454685;2330003;24090084;2449432;25187647;25687571;38843836", "class_list": "", "function": "Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). When present in a hybrid receptor with IGF1R, binds IGF1 (By similarity). In adipocytes, inhibits lipolysis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 28, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "P97681", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005635 nuclear envelope;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032410 negative regulation of transporter activity;GO:0051446 positive regulation of meiotic cell cycle;GO:2000194 regulation of female gonad development;GO:2000252 negative regulation of feeding behavior;GO:1990402 embryonic liver development", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P15127-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUH6-1", "uniprot_id": [ { "id": "SYGP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUH6", "type": "external" } ], "mass": 144722.0, "length": 1308, "protein_name": "Ras/Rap GTPase-activating protein SynGAP", "gene_name": "Syngap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Syngap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras/Rap GTPase-activating protein SynGAP; Neuronal RasGAP; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; p135 SynGAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autosomal dominant intellectual developmental disorder 5 (Disease Ontology:DOID:0070035); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (R-RNO-5658442)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "11278737;15312654;15500970;16054660;16507876;16537406;17496889;18323856;19322778;21382555;22645316;22673903;35637289;38843836;9581761;9620694", "class_list": "", "function": "Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 21, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 21, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 21, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 27, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "O88449;Q9ESK6;Q9ET81;Q9QX02;Q9QX06;Q9QX12", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043198 dendritic shaft", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0008542 visual learning;GO:0016358 dendrite development;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "Q9QUH6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q501R9-1", "uniprot_id": [ { "id": "NBR1_RAT", "url": "https://www.uniprot.org/uniprot/Q501R9", "type": "external" } ], "mass": 109829.0, "length": 983, "protein_name": "Next to BRCA1 gene 1 protein", "gene_name": "Nbr1", "organism": "Rat", "refseq_name": "next to BRCA1 gene 1 protein", "refseq_ac": [ { "id": "NP_001019936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019936", "type": "external" } ], "gene_names_uniprotkb": "Nbr1", "gene_names_refseq": "Ca125; Nbr1; RGD1311421", "protein_names_uniprotkb": "Next to BRCA1 gene 1 protein; Neighbor of BRCA1 gene 1 protein", "protein_names_refseq": "neighbor of BRCA1 gene 1 protein; next to BRCA1 gene 1 protein; next to the Brca1; ovarian carcinoma antigen CA125", "tax_id": 10116, "disease": "", "pathway": " (rno:303554); (R-RNO-9664873)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11179671;15802564;22673903", "class_list": "", "function": "Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation (By similarity). In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Also plays non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHG4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051019 mitogen-activated protein kinase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "GO:0016236 macroautophagy;GO:0030500 regulation of bone mineralization;GO:0045668 negative regulation of osteoblast differentiation;GO:0032872 regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q501R9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI07-1", "uniprot_id": [ { "id": "LPP_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI07", "type": "external" } ], "mass": 68260.0, "length": 632, "protein_name": "Lipoma-preferred partner homolog", "gene_name": "Lpp", "organism": "Rat", "refseq_name": "lipoma-preferred partner homolog isoform 1", "refseq_ac": [ { "id": "NP_001013886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013886", "type": "external" } ], "gene_names_uniprotkb": "Lpp", "gene_names_refseq": "Lpp", "protein_names_uniprotkb": "Lipoma-preferred partner homolog", "protein_names_refseq": "Lipoma-preferred-partner; lipoma-preferred partner homolog isoform 1; lipoma-preferred partner homolog", "tax_id": 10116, "disease": "acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:288010)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;23504181;34502162;41549750", "class_list": "", "function": "LPP knockdown by small intefering RNA led to formation of alpha-actinin aggregates and Z bodies showing that myofibrillogenesis was impaired, [RefSeq, PubMed]; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0001725 stress fiber", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5XI07-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1J8-1", "uniprot_id": [ { "id": "P3H1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1J8", "type": "external" } ], "mass": 82390.0, "length": 728, "protein_name": "Prolyl 3-hydroxylase 1", "gene_name": "P3h1", "organism": "Rat", "refseq_name": "prolyl 3-hydroxylase 1 precursor", "refseq_ac": [ { "id": "NP_446119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446119", "type": "external" } ], "gene_names_uniprotkb": "P3h1; Lepre1", "gene_names_refseq": "Gros1; Lepre1; P3h1", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 1; 1.14.11.7; Leprecan-1; Leucine- and proline-enriched proteoglycan 1", "protein_names_refseq": "growth supressor 1; leprecan-1; leucine proline-enriched proteoglycan (leprecan) 1; leucine- and proline-enriched proteoglycan 1; prolyl 3-hydroxylase 1 precursor", "tax_id": 10116, "disease": "osteogenesis imperfecta type 8 (Disease Ontology:DOID:0110336)", "pathway": " (rno:114200); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10455179;17495866", "class_list": "", "function": "Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen trimers (By similarity). May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity)., [UniProtKB, UniProtKB]; Regulated expression of leprecan during glomerular development or hypertrophy coupled with its reported prolyl hydroxylase activity plays a role during basement membrane assembly., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005604 basement membrane", "go_biological_process": "GO:1901874 negative regulation of post-translational protein modification;GO:0010976 positive regulation of neuron projection development;GO:0030199 collagen fibril organization;GO:0050821 protein stabilization;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1J8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Y7-1", "uniprot_id": [ { "id": "NOE2_RAT", "url": "https://www.uniprot.org/uniprot/Q568Y7", "type": "external" } ], "mass": 53870.0, "length": 478, "protein_name": "Noelin-2", "gene_name": "Olfm2", "organism": "Rat", "refseq_name": "noelin-2 precursor", "refseq_ac": [ { "id": "NP_001015017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015017", "type": "external" } ], "gene_names_uniprotkb": "Olfm2", "gene_names_refseq": "Olfm2", "protein_names_uniprotkb": "Noelin-2; Olfactomedin-2", "protein_names_refseq": "noelin-2 precursor; noelin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:313783)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21228389;22632720;28062493;38843836", "class_list": "", "function": "Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (PubMed:28062493)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Olfactomedin 2 regulates vascular smooth muscle phenotype and vascular remodeling by regulating Runx2/serum response factor interaction., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A6JNL2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1905174 regulation of vascular associated smooth muscle cell dedifferentiation;GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0007601 visual perception;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q568Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TMB7-1", "uniprot_id": [ { "id": "PLPR4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TMB7", "type": "external" } ], "mass": 83362.0, "length": 766, "protein_name": "Phospholipid phosphatase-related protein type 4", "gene_name": "Plppr4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plppr4; Lppr4; Php1; Prg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 4; Brain-specific phosphatidic acid phosphatase-like protein 1; Inactive 2-lysophosphatidate phosphatase PLPPR4; Lipid phosphate phosphatase-related protein type 4; PRG-1; Plasticity-related gene 1 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:295401); (R-RNO-419408)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12730698;15280885;22673903;38843836", "class_list": "", "function": "Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse (PubMed:12730698)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007409 axonogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0048839 inner ear development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TMB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04176-1", "uniprot_id": [ { "id": "PH4H_RAT", "url": "https://www.uniprot.org/uniprot/P04176", "type": "external" } ], "mass": 51822.0, "length": 453, "protein_name": "Phenylalanine-4-hydroxylase", "gene_name": "Pah", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pah", "gene_names_refseq": "", "protein_names_uniprotkb": "Phenylalanine-4-hydroxylase; 1.14.16.1; PAH; Phe-4-monooxygenase", "protein_names_refseq": "", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); phenylketonuria (Disease Ontology:DOID:9281)", "pathway": " (rno:24616); (R-RNO-8964208)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10331871;22673903;2869038;6098294;7387651;7407194", "class_list": "", "function": "Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0006571 tyrosine biosynthetic process;GO:0006559 L-phenylalanine catabolic process;GO:0006558 L-phenylalanine metabolic process;GO:0018126 protein hydroxylation;GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04176-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62920-1", "uniprot_id": [ { "id": "PDLI5_RAT", "url": "https://www.uniprot.org/uniprot/Q62920", "type": "external" } ], "mass": 63201.0, "length": 591, "protein_name": "PDZ and LIM domain protein 5", "gene_name": "Pdlim5", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 5", "refseq_ac": [ { "id": "NP_445778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445778", "type": "external" } ], "gene_names_uniprotkb": "Pdlim5; Enh", "gene_names_refseq": "Enh1; Enh; Pdlim5", "protein_names_uniprotkb": "PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein", "protein_names_refseq": "PDZ and LIM domain protein 5; enigma homolog; enigma-like PDZ and LIM domains protein", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:64353)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10833443;12665800;16549780;16641100;19900557;20097676;22673903;25524223;26365342;27289039;34502162;8940095", "class_list": "", "function": "ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors, [RefSeq, PubMed]; ENH protein, by interacting specifically with both protein kinase C (PKC)epsilon and the N-type Ca2+ channel, targets a specific PKC to its substrate to form a functional signaling complex., [RefSeq, PubMed]; ENH1 plays an essential role in CREB's activation and dependent transcription in cardiomyocytes., [RefSeq, PubMed]; May play an important role in the heart development by scaffolding PKC to the Z-disk region (PubMed:20097676, PubMed:8940095). May play a role in the regulation of cardiomyocyte expansion (PubMed:20097676). Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1 (PubMed:20097676). Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons (PubMed:20097676). May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation (PubMed:19900557)., [UniProtKB, PubMed, PubMed, PubMed]; PDLIM5 acts as a scaffold protein by mediated PKCepsilon translocated to the membrane in PMA-induced growth cone collapse., [RefSeq, PubMed]; Results suggest that, in healthy conditions, RBM20 and RBM24 cooperate to promote the expression of short ENH isoforms., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005912 adherens junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061049 cell growth involved in cardiac muscle cell development;GO:0051963 regulation of synapse assembly;GO:0061001 regulation of dendritic spine morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q62920-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK26-1", "uniprot_id": [ { "id": "PLPL7_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK26", "type": "external" } ], "mass": 150024.0, "length": 1349, "protein_name": "Patatin-like phospholipase domain-containing protein 7", "gene_name": "Pnpla7", "organism": "Rat", "refseq_name": "patatin-like phospholipase domain-containing protein 7", "refseq_ac": [ { "id": "NP_653339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653339", "type": "external" } ], "gene_names_uniprotkb": "Pnpla7; Nre; Ntel1", "gene_names_refseq": "Nte-related; Ntel1; Ntel; Pnpla7", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 7; 3.1.1.-; 3.1.1.5; Liver NTE-related protein 1; NTE-related esterase", "protein_names_refseq": "NTE-related esterase; liver NTE-related protein 1; neuropathy target esterase like 1; patatin-like phospholipase domain containing 7; patatin-like phospholipase domain-containing protein 7-like; patatin-like phospholipase domain-containing protein 7", "tax_id": 10116, "disease": "cerebellar ataxia (Disease Ontology:DOID:0050753); neurodegenerative disease (Disease Ontology:DOID:1289); blindness (Disease Ontology:DOID:1432); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:246246)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12893290;22673903;29393594", "class_list": "", "function": "Lysophospholipase which preferentially deacylates unsaturated lysophosphatidylcholine (C18:1), generating glycerophosphocholine. Also can deacylate, to a lesser extent, lysophosphatidylethanolamine (C18:1), lysophosphatidyl-L-serine (C18:1) and lysophosphatidic acid (C16:0)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIX2;Q8K3H9", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BK26-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2N3-1", "uniprot_id": [ { "id": "PITM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2N3", "type": "external" } ], "mass": 134984.0, "length": 1242, "protein_name": "Membrane-associated phosphatidylinositol transfer protein 1", "gene_name": "Pitpnm1", "organism": "Rat", "refseq_name": "membrane-associated phosphatidylinositol transfer protein 1", "refseq_ac": [ { "id": "NP_001008370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008370", "type": "external" } ], "gene_names_uniprotkb": "Pitpnm1; Nir2; Pitpnm", "gene_names_refseq": "Pitpnm1; Pitpnm", "protein_names_uniprotkb": "Membrane-associated phosphatidylinositol transfer protein 1; NIR-2; PITPnm 1; Phosphatidylinositol transfer protein, membrane-associated 1; Pyk2 N-terminal domain-interacting receptor 2", "protein_names_refseq": "NIR-2; PITPnm 1; membrane-associated phosphatidylinositol transfer protein 1; phosphatidylinositol membrane-associated; pyk2 N-terminal domain-interacting receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361694); (R-RNO-1483226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma-membrane phosphoinositide signaling competence. Transfers phosphatidylinositol from the endoplasmic reticulum to the plasma membrane and mediates counter-transport of phosphatidic acid (PA) from the plasma membrane to the endoplasmic reticulum at endoplasmic reticulum-plasma membrane contact sites, this PI/PA exchange is required for sustained PLC-coupled receptor signaling and for replenishment of plasma membrane phosphoinositide following receptor-induced hydrolysis. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0031210 phosphatidylcholine binding;GO:0035091 phosphatidylinositol binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0044297 cell body", "go_biological_process": "GO:0015031 protein transport;GO:0015914 phospholipid transport;GO:1902633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2N3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54968-1", "uniprot_id": [ { "id": "NF2L2_RAT", "url": "https://www.uniprot.org/uniprot/O54968", "type": "external" } ], "mass": 67703.0, "length": 604, "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "Nfe2l2", "organism": "Rat", "refseq_name": "nuclear factor erythroid 2-related factor 2 isoform 2", "refseq_ac": [ { "id": "NP_113977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113977", "type": "external" } ], "gene_names_uniprotkb": "Nfe2l2; Nrf2", "gene_names_refseq": "Nfe2l2", "protein_names_uniprotkb": "Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2", "protein_names_refseq": "NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; nrf2; nuclear factor erythroid 2-related factor 2 isoform 2; nuclear factor erythroid 2-related factor 2; nuclear factor, erythroid 2-like 2; nuclear factor, erythroid derived 2, like 2", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Huntington's disease (Disease Ontology:DOID:12858); extrahepatic cholestasis (Disease Ontology:DOID:13619); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); tuberculosis (Disease Ontology:DOID:399); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); visceral leishmaniasis (Disease Ontology:DOID:9146); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83619); (R-RNO-8951664); (R-RNO-9755511); (R-RNO-9759194); (R-RNO-9762114)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "12198130;16314513;23022408;25504008;25671364;30504707;31182708;35842499;38943181;38944076;39084457;39097921;39264079", "class_list": "", "function": "BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal cells caused by spinal cord injury via the UBE2Z/NRF2 pathway., [RefSeq, PubMed]; Effects of Life-Long Exercise on Age-Related Inflammation, Apoptosis, Oxidative Stress, Ferroptosis Markers, and NRF2/KAEP 1/Klotho Pathway in Rat Kidneys., [RefSeq, PubMed]; Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-kappaB signaling., [RefSeq, PubMed]; PKC-catalyzed phosphorylation of Nrf2 at Ser-40 is a critical signaling event leading to ARE-mediated cellular antioxidant response, [RefSeq, PubMed]; Platelet-derived exosomes alleviate tendon stem/progenitor cell senescence and ferroptosis by regulating AMPK/Nrf2/GPX4 signaling and improve tendon-bone junction regeneration in rats. Publication Status: Online-Only, [RefSeq, PubMed]; The mechanism of NRF2 regulating cell proliferation and mesenchymal transformation in pulmonary hypertension., [RefSeq, PubMed]; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:16314513). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes. The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (By similarity). The NFE2L2/NRF2 pathway is also activated during the unfolded protein response (UPR), contributing to redox homeostasis and cell survival following endoplasmic reticulum stress (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). Also plays an important role in the regulation of the innate immune response. It is a critical regulator of the innate immune response and survival during sepsis by maintaining redox homeostasis and restraint of the dysregulation of pro-inflammatory signaling pathways like MyD88-dependent and -independent and TNF signaling. Suppresses macrophage inflammatory response by blocking pro-inflammatory cytokine transcription and the induction of IL6. Binds to the proximity of pro-inflammatory genes in macrophages and inhibits RNA Pol II recruitment. The inhibition is independent of the Nrf2-binding motif and reactive oxygen species level (By similarity). Represses antiviral cytosolic DNA sensing by suppressing the expression of the adapter protein STING1 and decreasing responsiveness to STING1 agonists while increasing susceptibility to infection with DNA viruses (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 4, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7C8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0046223 aflatoxin catabolic process;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:1903788 positive regulation of glutathione biosynthetic process;GO:0002931 response to ischemia", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O54968-1", "record_type": "protein", "filter_code": "0000000.0110111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36202-1", "uniprot_id": [ { "id": "PDLI4_RAT", "url": "https://www.uniprot.org/uniprot/P36202", "type": "external" } ], "mass": 35521.0, "length": 330, "protein_name": "PDZ and LIM domain protein 4", "gene_name": "Pdlim4", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 4 isoform 2", "refseq_ac": [ { "id": "NP_058758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058758", "type": "external" } ], "gene_names_uniprotkb": "Pdlim4; Ril", "gene_names_refseq": "H-Rev18; Pdlim4; Ril", "protein_names_uniprotkb": "PDZ and LIM domain protein 4; H-REV18; LIM protein RIL; RIT-18; Reversion-induced LIM protein", "protein_names_refseq": "LIM protein RIL; PDZ and LIM domain protein 4 isoform 2; PDZ and LIM domain protein 4; RIT-18; reversion induced LIM; reversion-induced LIM protein", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); discrete subaortic stenosis (Disease Ontology:DOID:5804); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24915)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14729062;15456832;22659164;22673903;38968989;7824279", "class_list": "", "function": "Reversion induced LIM domain protein (RIL) is a Daam1-interacting protein and regulator of the actin cytoskeleton during non-canonical Wnt signaling., [RefSeq, PubMed]; Ril modulates actin stress fiber turnover and enhances the association with actinin and actins., [RefSeq, PubMed]; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (By similarity). Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers (PubMed:14729062, PubMed:22659164). Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (PubMed:15456832)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; The RIL has a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051393 alpha-actinin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034777 recycling endosome lumen;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0051496 positive regulation of stress fiber assembly;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36202-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHH1-1", "uniprot_id": [ { "id": "DLL4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHH1", "type": "external" } ], "mass": 74961.0, "length": 686, "protein_name": "Delta-like protein 4", "gene_name": "Dll4", "organism": "Rat", "refseq_name": "delta-like protein 4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001418638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418638", "type": "external" } ], "gene_names_uniprotkb": "Dll4", "gene_names_refseq": "Dll4", "protein_names_uniprotkb": "Delta-like protein 4; Delta4; Drosophila Delta homolog 4", "protein_names_refseq": "delta-like 4; delta-like protein 4 isoform 1 precursor; delta-like protein 4; delta4; drosophila Delta homolog 4", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); Adams-Oliver syndrome (Disease Ontology:DOID:0060227); polycystic kidney disease (Disease Ontology:DOID:0080322); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); hemangiopericytoma (Disease Ontology:DOID:264); ischemia (Disease Ontology:DOID:326); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); lung large cell carcinoma (Disease Ontology:DOID:4556); hemangioblastoma (Disease Ontology:DOID:5241); lung small cell carcinoma (Disease Ontology:DOID:5409); varicose veins (Disease Ontology:DOID:799); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (R-RNO-9013507)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25700513;37848121", "class_list": "", "function": "Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4 (PubMed:25700513). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate., [UniProtKB, UniProtKB]; Overexpression of miR-124 in astrocyte improves neurological deficits in rat with ischemic stroke via DLL4 modulation., [RefSeq, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:0061074 regulation of neural retina development;GO:0072554 blood vessel lumenization;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZHH1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62711-1", "uniprot_id": [ { "id": "PLCD4_RAT", "url": "https://www.uniprot.org/uniprot/Q62711", "type": "external" } ], "mass": 88967.0, "length": 772, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "gene_name": "Plcd4", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4", "refseq_ac": [ { "id": "NP_542419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542419", "type": "external" } ], "gene_names_uniprotkb": "Plcd4", "gene_names_refseq": "Plcd4", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; 3.1.4.11; PLC-delta-4; Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC-delta-4; phosphoinositide phospholipase C-delta-4", "tax_id": 10116, "disease": "", "pathway": " (rno:140693); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11706040;15037625;17063484;22673903;8550568;8550586;9915823", "class_list": "", "function": "Has no enzyme activity and acts as a negative regulator of phospholipase C, with a preference for thePLC-delta family., [UniProtKB, PubMed]; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63693", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0007340 acrosome reaction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62711-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RI88-1", "uniprot_id": [ { "id": "S4A5_RAT", "url": "https://www.uniprot.org/uniprot/Q6RI88", "type": "external" } ], "mass": 123944.0, "length": 1112, "protein_name": "Electrogenic sodium bicarbonate cotransporter 4", "gene_name": "Slc4a5", "organism": "Rat", "refseq_name": "electrogenic sodium bicarbonate cotransporter 4", "refseq_ac": [ { "id": "NP_997677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997677", "type": "external" } ], "gene_names_uniprotkb": "Slc4a5", "gene_names_refseq": "NBC4; Slc4a5", "protein_names_uniprotkb": "Electrogenic sodium bicarbonate cotransporter 4; Solute carrier family 4 member 5", "protein_names_refseq": "electrogenic sodium bicarbonate cotransporter 4; electrogenic sodium bicarbonate cotransporter NBC4c; sodium bicarbonate transporter 4; solute carrier family 4, sodium bicarbonate cotransporter, member 5", "tax_id": 10116, "disease": "anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:297386); (R-RNO-425381)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12388414;15151908", "class_list": "", "function": "Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3., [UniProtKB, UniProtKB]; The cotransporter plays a role in mediating Na(+)-HCO(3)(-) cotransport in hepatocytes and intrahepatic cholangiocytes. the cotransporter may play an important role in protecting the renal parenchyma from alterations in urine pH., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport;GO:0060041 retina development in camera-type eye;GO:0003073 regulation of systemic arterial blood pressure;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6RI88-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08721-1", "uniprot_id": [ { "id": "UNC5A_RAT", "url": "https://www.uniprot.org/uniprot/O08721", "type": "external" } ], "mass": 98841.0, "length": 898, "protein_name": "Netrin receptor UNC5A", "gene_name": "Unc5a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Unc5a; Unc5h1", "gene_names_refseq": "", "protein_names_uniprotkb": "Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:60629); (R-RNO-373752)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10399920;11387206;11472849;12598531;14672991;18582460;19755150;9126742", "class_list": "", "function": "Receptor for netrin required for axon guidance (PubMed:9126742). Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1 (PubMed:19755150). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206, PubMed:12598531)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 5, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0006915 apoptotic process;GO:0007411 axon guidance;GO:0038007 netrin-activated signaling pathway;GO:0033564 anterior/posterior axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08721-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010100.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63744-1", "uniprot_id": [ { "id": "RHG07_RAT", "url": "https://www.uniprot.org/uniprot/Q63744", "type": "external" } ], "mass": 123414.0, "length": 1091, "protein_name": "Rho GTPase-activating protein 7", "gene_name": "Dlc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dlc1; Arhgap7; Rhogap; Stard12", "gene_names_refseq": "", "protein_names_uniprotkb": "Rho GTPase-activating protein 7; DLC-1; Deleted in liver cancer 1 protein homolog; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StAR-related lipid transfer protein 12; StARD12; p122-RhoGAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "gonadal dysgenesis (Disease Ontology:DOID:14447); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:58834); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013406)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10364218;16338927;22673903;7835339", "class_list": "", "function": "Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity). Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity). The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008289 lipid binding;GO:0042169 SH2 domain binding;GO:0017166 vinculin binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005925 focal adhesion", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0030900 forebrain development;GO:0032869 cellular response to insulin stimulus;GO:0035556 intracellular signal transduction;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63744-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXD8-1", "uniprot_id": [ { "id": "TM245_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXD8", "type": "external" } ], "mass": 97282.0, "length": 876, "protein_name": "Transmembrane protein 245", "gene_name": "Tmem245", "organism": "Rat", "refseq_name": "transmembrane protein 245", "refseq_ac": [ { "id": "NP_001406500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406500", "type": "external" } ], "gene_names_uniprotkb": "Tmem245", "gene_names_refseq": "RGD1308958; Tmem245", "protein_names_uniprotkb": "Transmembrane protein 245", "protein_names_refseq": "transmembrane protein 245", "tax_id": 10116, "disease": "", "pathway": " (rno:298020)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZXD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIR1-1", "uniprot_id": [ { "id": "RIMB2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIR1", "type": "external" } ], "mass": 115614.0, "length": 1049, "protein_name": "RIMS-binding protein 2", "gene_name": "Rimbp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rimbp2; Rbp2", "gene_names_refseq": "", "protein_names_uniprotkb": "RIMS-binding protein 2; RIM-BP2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:266780)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10748113;22673903", "class_list": "", "function": "Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0030674 protein-macromolecule adaptor activity;GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0098681 synaptic ribbon", "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion;GO:0099505 regulation of presynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIR1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKC9-1", "uniprot_id": [ { "id": "NGEF_RAT", "url": "https://www.uniprot.org/uniprot/Q5BKC9", "type": "external" } ], "mass": 81008.0, "length": 701, "protein_name": "Ephexin-1", "gene_name": "Ngef", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ngef", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:246217); (R-RNO-193648); (R-RNO-3928663); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "11336673;15848799", "class_list": "", "function": "Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030426 growth cone;GO:0098794 postsynapse", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0032956 regulation of actin cytoskeleton organization;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BKC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQG6-1", "uniprot_id": [ { "id": "TRIM2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQG6", "type": "external" } ], "mass": 81427.0, "length": 744, "protein_name": "Tripartite motif-containing protein 2", "gene_name": "Trim2", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001102022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102022", "type": "external" } ], "gene_names_uniprotkb": "Trim2", "gene_names_refseq": "Trim2", "protein_names_uniprotkb": "Tripartite motif-containing protein 2; 2.3.2.27; E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2; tripartite motif protein 2; tripartite motif-containing protein 2 isoform 1; tripartite motif-containing protein 2", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 2R (Disease Ontology:DOID:0110161); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:361970)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21478148;22673903;34291866;38843836", "class_list": "", "function": "A role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance., [RefSeq, PubMed]; MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of retinal ganglion cells via the PI3K/AKT signaling pathway in glaucoma., [RefSeq, PubMed]; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZQG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UPR8-1", "uniprot_id": [ { "id": "ERMP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6UPR8", "type": "external" } ], "mass": 99897.0, "length": 898, "protein_name": "Endoplasmic reticulum metallopeptidase 1", "gene_name": "Ermp1", "organism": "Rat", "refseq_name": "endoplasmic reticulum metallopeptidase 1", "refseq_ac": [ { "id": "NP_908939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_908939", "type": "external" } ], "gene_names_uniprotkb": "Ermp1; Fxna", "gene_names_refseq": "Ermp1; Fxna", "protein_names_uniprotkb": "Endoplasmic reticulum metallopeptidase 1; 3.4.-.-; Felix-ina", "protein_names_refseq": "endoplasmic reticulum metallopeptidase 1; felix-ina; putative aminopeptidase Fxna", "tax_id": 10116, "disease": "chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:373544)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17267443;23679341;31500865", "class_list": "", "function": "Fxna is required for the organization of somatic cells and oocytes into discrete follicular structure. Fxna may facilitate follicular organization by processing precursor proteins required for intraovarian cell-to-cell communication., [RefSeq, PubMed]; Results suggest that the attenuation of miR-9 on ischemic injury may be involved in targeting ERMP1-mediated ER stress, which provides an available target for Ischemic stroke treatment, [RefSeq, PubMed]; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0034599 cellular response to oxidative stress;GO:0001541 ovarian follicle development;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6UPR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80T22-1", "uniprot_id": [ { "id": "S60A2_RAT", "url": "https://www.uniprot.org/uniprot/Q80T22", "type": "external" } ], "mass": 51733.0, "length": 484, "protein_name": "Solute carrier family 60 member 1", "gene_name": "Naglt1; Slc60a2", "organism": "Rat", "refseq_name": "solute carrier family 60 member 1", "refseq_ac": [ { "id": "NP_788269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788269", "type": "external" } ], "gene_names_uniprotkb": "Naglt1; Slc60a2; Mfsd4b; Naglt1", "gene_names_refseq": "Mfsd4b; Naglt1; Slc60a2", "protein_names_uniprotkb": "Solute carrier family 60 member 1; Major facilitator superfamily domain-containing protein 4B; Sodium-dependent glucose transporter 1; rNaGLT1", "protein_names_refseq": "major facilitator superfamily domain-containing protein 4B; rNaGLT1; sodium-dependent glucose transporter 1; solute carrier family 60 member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:337920)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12590146;12832054;16627065;22673903;26423860", "class_list": "", "function": "Cloning and characterization of rNaGLT1 suggests it is a novel Na(+)-dependent glucose transporter with low substrate affinity that mediates kidney tubular reabsorption of glucose., [RefSeq, PubMed]; Low-affinity Na(+)-dependent glucose symporter with a Na(+) to glucose coupling ratio of 1:1 (PubMed:12590146). Potential channels for urea in the inner medulla of kidney (PubMed:26423860)., [UniProtKB, PubMed, PubMed]; Role in fructose transport in rat kidney, [RefSeq, PubMed]; Vagal innervation appears to differentially mediate the diurnal changes in hexose transporter mRNA and protein expression in the rat jejunum by posttranscriptional, and/or posttranslational processes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JSX3;A6KIH8;Q4KMB5", "ec_number_list": [], "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0098708 D-glucose import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80T22-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62771-1", "uniprot_id": [ { "id": "STA5A_RAT", "url": "https://www.uniprot.org/uniprot/Q62771", "type": "external" } ], "mass": 90833.0, "length": 793, "protein_name": "Signal transducer and activator of transcription 5A", "gene_name": "Stat5a", "organism": "Rat", "refseq_name": "signal transducer and activator of transcription 5A", "refseq_ac": [ { "id": "NP_058760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058760", "type": "external" } ], "gene_names_uniprotkb": "Stat5a; Mgf", "gene_names_refseq": "Stat5a; Stat5", "protein_names_uniprotkb": "Signal transducer and activator of transcription 5A; Mammary gland factor", "protein_names_refseq": "mammary gland factor; signal transducer and activator of transcription 5A; signal transducer and activator of transcription 5", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); growth hormone insensitivity syndrome with immune dysregulation 1 (Disease Ontology:DOID:0080836); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); prostate cancer (Disease Ontology:DOID:10283); colon adenocarcinoma (Disease Ontology:DOID:234); glioblastoma (Disease Ontology:DOID:3068); invasive lobular carcinoma (Disease Ontology:DOID:3457); gastric adenocarcinoma (Disease Ontology:DOID:3717); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:24918); (R-RNO-1251985); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-186763); (R-RNO-512988); (R-RNO-8854691); (R-RNO-8983432); (R-RNO-8985947); (R-RNO-9020558); (R-RNO-9020958); (R-RNO-982772)", "pathway_count": 12, "publication_count": 8, "publication_id_list": "16227201;19088846;22673903;35143864;35320597;36195691;37232379;8584036", "class_list": "", "function": "Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation., [UniProtKB, PubMed]; MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes., [RefSeq, PubMed]; Prolactin Regulates Testicular Gene Expression and Cell Cycle Processes Predominantly via JAK2/STAT5 Pathway in the Male Rat., [RefSeq, PubMed]; STAT5A modulated EndMT via upregulation of ELTD1 expression in diabetic nephropathy., [RefSeq, PubMed]; Silencing of Long Noncoding RNA GAS5 Blocks Experimental Cerebral Ischemia-Reperfusion Injury by Restraining AQP4 Expression via the miR-1192/STAT5A Axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:0046543 development of secondary female sexual characteristics;GO:0033026 negative regulation of mast cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62771-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10362-1", "uniprot_id": [ { "id": "SCG2_RAT", "url": "https://www.uniprot.org/uniprot/P10362", "type": "external" } ], "mass": 71031.0, "length": 619, "protein_name": "Secretogranin-2", "gene_name": "Scg2", "organism": "Rat", "refseq_name": "secretogranin-2 precursor", "refseq_ac": [ { "id": "NP_073160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073160", "type": "external" } ], "gene_names_uniprotkb": "Scg2; Chgc; Scg-2", "gene_names_refseq": "Chcg; Scg2", "protein_names_uniprotkb": "Secretogranin-2; Chromogranin-C; Secretogranin II; SgII", "protein_names_refseq": "Chromogranin C (Secretogranin II); chromogranin-C; secretogranin II (chromogranin C); secretogranin-2 precursor; secretogranin-2; sgII", "tax_id": 10116, "disease": "", "pathway": " (rno:24765); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15257142;22655045;22673903;22682498;24360019;28902709;3211750;8321414;9654353", "class_list": "", "function": "EM66 (peptide derived from SCG2) gene expression is modulated by a negative energy status and suggest interactions between EM66 and NPY to regulate food intake through the POMC system., [RefSeq, PubMed]; Manserin localizes to rat thyroid follicular epithelial cells and also to some parafollicular cells, [RefSeq, PubMed]; Manserin localizes to secretory cells in the oviduct and may be involved in stress-induced gynecological disorders., [RefSeq, PubMed]; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The secretogranin II fragment secretoneurin reduces ischemia/reperfusion injury in the isolated perfused rat heart., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0031045 dense core granule;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0000165 MAPK cascade;GO:0001938 positive regulation of endothelial cell proliferation;GO:2000352 negative regulation of endothelial cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10362-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4U9-1", "uniprot_id": [ { "id": "SGK2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4U9", "type": "external" } ], "mass": 41361.0, "length": 367, "protein_name": "Serine/threonine-protein kinase Sgk2", "gene_name": "Sgk2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Sgk2", "refseq_ac": [ { "id": "NP_604458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604458", "type": "external" } ], "gene_names_uniprotkb": "Sgk2", "gene_names_refseq": "Sgk2", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk2; 2.7.11.1; Serum/glucocorticoid-regulated kinase 2", "protein_names_refseq": "SGK2, serine/threonine kinase 2; serine/threonine-protein kinase Sgk2", "tax_id": 10116, "disease": "", "pathway": " (rno:171497); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15504348;19447520;20926631;22673903", "class_list": "", "function": "Results suggest that pattern of expression, regulation, and role of sgk2 within mammalian kidney are distinct from sgk1 and that sgk2 may play previously unrecognized role in control of transtubular Na(+) transport through NHE3 in the proximal tubule., [RefSeq, PubMed]; SGK1 expression during liver regeneration is a part of a signaling pathway that is necessary for enhancing ERK signaling activation through modulating the MEK/ERK complex formation., [RefSeq, PubMed]; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8R4U9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Y7-1", "uniprot_id": [ { "id": "CANT1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4Y7", "type": "external" } ], "mass": 45659.0, "length": 403, "protein_name": "Soluble calcium-activated nucleotidase 1", "gene_name": "Cant1", "organism": "Rat", "refseq_name": "soluble calcium-activated nucleotidase 1", "refseq_ac": [ { "id": "NP_653355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653355", "type": "external" } ], "gene_names_uniprotkb": "Cant1; Srapy", "gene_names_refseq": "Cant1; srapy", "protein_names_uniprotkb": "Soluble calcium-activated nucleotidase 1; 3.6.1.6; Apyrase homolog; SCAN-1", "protein_names_refseq": "SCAN-1; apyrase homolog; ectonucleoside triphosphate diphosphohydrolase 8; soluble calcium-activated nucleotidase 1", "tax_id": 10116, "disease": "Desbuquois dysplasia (Disease Ontology:DOID:0060462); multiple epiphyseal dysplasia 7 (Disease Ontology:DOID:0070302)", "pathway": " (rno:246272); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12167635;16758353;19169047", "class_list": "", "function": "Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12167635). Involved in proteoglycan synthesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results show that apyrase and 5'-nucleotidase activities are altered in demyelination events, [RefSeq, PubMed]; Soluble apyrase as well as the glomerular ENTPD1 are sensitive to oxidant stress, which may explain their downregulation in the ischemic condition in vivo. However, soluble 5'-nucleotidase and E5NT seem much less sensitive to ROS, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8N9", "ec_number_list": [ { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": 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"external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": 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"type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": 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"type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0045134 UDP phosphatase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K4Y7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42893-1", "uniprot_id": [ { "id": "ECE1_RAT", "url": "https://www.uniprot.org/uniprot/P42893", "type": "external" } ], "mass": 86126.0, "length": 762, "protein_name": "Endothelin-converting enzyme 1", "gene_name": "Ece1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ece1", "gene_names_refseq": "", "protein_names_uniprotkb": "Endothelin-converting enzyme 1; 3.4.24.71; ECE-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); nephrotic syndrome (Disease Ontology:DOID:1184); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); double outlet right ventricle (Disease Ontology:DOID:6406); pulmonary hypertension (Disease Ontology:DOID:6432); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (R-RNO-375276)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10491078;21454685;22673903;29393594;7672114;8034569;8645169", "class_list": "", "function": "Converts big endothelin-1 to endothelin-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUY8;Q9WUY9", "ec_number_list": [ { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0007507 heart development;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0031175 neuron projection development;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P42893-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63175-1", "uniprot_id": [ { "id": "SERC5_RAT", "url": "https://www.uniprot.org/uniprot/Q63175", "type": "external" } ], "mass": 51856.0, "length": 460, "protein_name": "Serine incorporator 5", "gene_name": "Serinc5", "organism": "Rat", "refseq_name": "serine incorporator 5", "refseq_ac": [ { "id": "NP_596886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596886", "type": "external" } ], "gene_names_uniprotkb": "Serinc5; Tpo1", "gene_names_refseq": "Serinc5; Tpo1", "protein_names_uniprotkb": "Serine incorporator 5; Developmentally regulated protein TPO1", "protein_names_refseq": "developmentally regulated protein TPO1; serine incorporator 5", "tax_id": 10116, "disease": "", "pathway": " (rno:170907); (R-RNO-977347)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16120614;9326262", "class_list": "", "function": "Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (PubMed:16120614, PubMed:9326262)., [UniProtKB, UniProtKB, PubMed, PubMed]; Serinc proteins incorporate serine into membrane lipid synthesis, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3V9U9", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017128 phospholipid scramblase activity;GO:0010698 acetyltransferase activator activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043209 myelin sheath", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0042552 myelination;GO:0017121 plasma membrane phospholipid scrambling;GO:0008654 phospholipid biosynthetic process;GO:0006658 phosphatidylserine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LCV6-1", "uniprot_id": [ { "id": "EQTN_RAT", "url": "https://www.uniprot.org/uniprot/Q2LCV6", "type": "external" } ], "mass": 31388.0, "length": 280, "protein_name": "Equatorin", "gene_name": "Eqtn", "organism": "Rat", "refseq_name": "equatorin precursor", "refseq_ac": [ { "id": "NP_001034434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034434", "type": "external" } ], "gene_names_uniprotkb": "Eqtn; Afaf", "gene_names_refseq": "Afaf; Eqtn", "protein_names_uniprotkb": "Equatorin; Acrosome formation-associated factor", "protein_names_refseq": "Acrosome formation associated factor; acrosome formation-associated factor; equatorin precursor; equatorin, sperm acrosome associated", "tax_id": 10116, "disease": "", "pathway": " (rno:500502)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16831425;22673903", "class_list": "", "function": "Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis., [UniProtKB, PubMed]; Afaf expressed abundantly in the round spermatids, localized in the inner and outer membrane of forming acrosome, and declined in the maturing acrosomes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LP31", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0060478 acrosomal vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LCV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24329-1", "uniprot_id": [ { "id": "THTR_RAT", "url": "https://www.uniprot.org/uniprot/P24329", "type": "external" } ], "mass": 33407.0, "length": 297, "protein_name": "Thiosulfate sulfurtransferase", "gene_name": "Tst", "organism": "Rat", "refseq_name": "thiosulfate sulfurtransferase", "refseq_ac": [ { "id": "NP_036940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036940", "type": "external" } ], "gene_names_uniprotkb": "Tst", "gene_names_refseq": "RHODAN; Tst", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase; 2.8.1.1; Rhodanese", "protein_names_refseq": "Thiosulfate sulphurtransferase (rhodanese); rhodanese; thiosulfate sulfurtransferase, mitochondrial; thiosulfate sulfurtransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:25274); (R-RNO-1614558)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2018478;22673903;24098488;7608189;8702895", "class_list": "", "function": "Catalyzes the transfer of sulfur ion from thiosulfate to cyanide, although other thiol compounds, besides cyanide, can act as sulfur ion acceptors (PubMed:7608189). It also has weak mercaptopyruvate sulfurtransferase (MST) activity (PubMed:7608189). Has a pivotal role in cyanide detoxification (By similarity). Together with MRPL18, it acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0D4", "ec_number_list": [ { "id": "1.8.5.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.8", "type": "external" }, { "id": "2.8.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.1", "type": "external" } ], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0008097 5S rRNA binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051029 rRNA transport;GO:0030855 epithelial cell differentiation;GO:0035928 rRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24329-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1A6-1", "uniprot_id": [ { "id": "VIGLN_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1A6", "type": "external" } ], "mass": 141584.0, "length": 1268, "protein_name": "Vigilin", "gene_name": "Hdlbp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hdlbp; Hbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Vigilin; HDL-binding protein; High density lipoprotein-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (R-RNO-8964011)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0034364 high-density lipoprotein particle;GO:0016604 nuclear body;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006869 lipid transport;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1A6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63801-1", "uniprot_id": [ { "id": "TAF6_RAT", "url": "https://www.uniprot.org/uniprot/Q63801", "type": "external" } ], "mass": 72713.0, "length": 678, "protein_name": "Transcription initiation factor TFIID subunit 6", "gene_name": "Taf6", "organism": "Rat", "refseq_name": "transcription initiation factor TFIID subunit 6 isoform 1", "refseq_ac": [ { "id": "NP_001423393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423393", "type": "external" } ], "gene_names_uniprotkb": "Taf6; Taf2e", "gene_names_refseq": "TAF(II)80; TAFII70; Taf6", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 6; TAF(II)70; TAF(II)80; TAFII-80; TAFII70; TAFII80; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID 80 kDa subunit; p80", "protein_names_refseq": "TAF(II)70; TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kDa; TAFII-70; TAFII-80; TAFII80; TFIID subunit p80; transcription initiation factor TFIID 70 kDa subunit; transcription initiation factor TFIID 80 kDa subunit; transcription initiation factor TFIID subunit 6 isoform 1; transcription initiation factor TFIID subunit 6", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-674695); (R-RNO-6804756); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "16641100;22673903;7665101", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071339 MLL1 complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63801-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22831-1", "uniprot_id": [ { "id": "SYNPR_RAT", "url": "https://www.uniprot.org/uniprot/P22831", "type": "external" } ], "mass": 29107.0, "length": 265, "protein_name": "Synaptoporin", "gene_name": "Synpr", "organism": "Rat", "refseq_name": "synaptoporin precursor", "refseq_ac": [ { "id": "NP_076464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076464", "type": "external" } ], "gene_names_uniprotkb": "Synpr", "gene_names_refseq": "Synpr", "protein_names_uniprotkb": "Synaptoporin", "protein_names_refseq": "synaptoporin precursor; synaptorin", "tax_id": 10116, "disease": "", "pathway": " (rno:66030)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2206533;22673903", "class_list": "", "function": "Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERH1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse;GO:0016020 membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P22831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01830-1", "uniprot_id": [ { "id": "THY1_RAT", "url": "https://www.uniprot.org/uniprot/P01830", "type": "external" } ], "mass": 18172.0, "length": 161, "protein_name": "Thy-1 membrane glycoprotein", "gene_name": "Thy1", "organism": "Rat", "refseq_name": "thy-1 membrane glycoprotein preproprotein", "refseq_ac": [ { "id": "NP_036805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036805", "type": "external" } ], "gene_names_uniprotkb": "Thy1; Thy-1", "gene_names_refseq": "CD7; Thy1", "protein_names_uniprotkb": "Thy-1 membrane glycoprotein; Thy-1 antigen", "protein_names_refseq": "CD90; Thy-1 protein; Thymus cell surface antigen; thy-1 antigen; thy-1 glycoprotein; thy-1 membrane glycoprotein preproprotein; thy-1 membrane glycoprotein; thymus cell antigen 1, theta", "tax_id": 10116, "disease": "retinal ischemia (Disease Ontology:DOID:12510); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:24832); (R-RNO-163125)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10.1039/D0MO00044B;15569310;22673903;24090084;27765629;2857477;2864289;2886334;2897081;29341439;30049932;31841640;34106099;6118137;6130472;6149956", "class_list": "", "function": "Intracellular Ca2+ signals and Cx43 hemichannel opening participate as key steps in the regulation of Thy-1-induced astrocyte migration. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells., [RefSeq, PubMed]; THY1 is expressed in the anterior lobe of the rat pituitary gland.THY1 is a novel specific marker of thyrotropes, which produce TSH., [RefSeq, PubMed]; Therapeutic benefits of CD90-negative cardiac stromal cells in rats with a 30-day chronic infarct has been demonstrated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 31, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0005096 GTPase activator activity;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0007267 cell-cell signaling;GO:0043066 negative regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 5.1, "record_id": "P01830-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLA3-1", "uniprot_id": [ { "id": "UGGG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLA3", "type": "external" } ], "mass": 176431.0, "length": 1551, "protein_name": "UDP-glucose:glycoprotein glucosyltransferase 1", "gene_name": "Uggt1", "organism": "Rat", "refseq_name": "UDP-glucose:glycoprotein glucosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_598280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598280", "type": "external" } ], "gene_names_uniprotkb": "Uggt1; Gt; Ugcgl1; Uggt; Ugt1; Ugtr", "gene_names_refseq": "UGT1; Ugcgl1; Uggt1; Uggt; rUGT1", "protein_names_uniprotkb": "UDP-glucose:glycoprotein glucosyltransferase 1; 2.4.1.-; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UGT1; rUGT1", "protein_names_refseq": "RUGT; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein: glucosyltransferase UGGT; UDP-glucose:glycoprotein glucosyltransferase 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:171129)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10764828;11278576;11535823;12475965;14730348;1533626;15861139;19222173;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; UGGT recognizes the hydrophobic region of client glycoproteins., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0032991 protein-containing complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006457 protein folding;GO:0009306 protein secretion;GO:0051084 'de novo' post-translational protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JLA3-1", "record_type": "protein", "filter_code": "0000000.1100101.010000.000000000000001000.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IRE4-1", "uniprot_id": [ { "id": "TS101_RAT", "url": "https://www.uniprot.org/uniprot/Q6IRE4", "type": "external" } ], "mass": 44078.0, "length": 391, "protein_name": "Tumor susceptibility gene 101 protein", "gene_name": "Tsg101", "organism": "Rat", "refseq_name": "tumor susceptibility gene 101 protein", "refseq_ac": [ { "id": "NP_853659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853659", "type": "external" } ], "gene_names_uniprotkb": "Tsg101", "gene_names_refseq": "Rw; Tsg101", "protein_names_uniprotkb": "Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101", "protein_names_refseq": "ESCRT-I complex subunit TSG101; Tumor supressor; tumor susceptibility gene 101 protein", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); endometrial adenocarcinoma (Disease Ontology:DOID:2870); cervix carcinoma (Disease Ontology:DOID:2893); carcinoma (Disease Ontology:DOID:305); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:292925); (R-RNO-917729)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14761944;30782301;34502162;38843836", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity)., [UniProtKB, UniProtKB]; Mechanical stress upregulates TSG101 in podocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSE5", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0003714 transcription corepressor activity;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005813 centrosome", "go_biological_process": "GO:1990182 exosomal secretion;GO:1903774 positive regulation of viral budding via host ESCRT complex;GO:2000397 positive regulation of ubiquitin-dependent endocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IRE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21818-1", "uniprot_id": [ { "id": "STMN2_RAT", "url": "https://www.uniprot.org/uniprot/P21818", "type": "external" } ], "mass": 20756.0, "length": 179, "protein_name": "Stathmin-2", "gene_name": "Stmn2", "organism": "Rat", "refseq_name": "stathmin-2", "refseq_ac": [ { "id": "NP_445892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445892", "type": "external" } ], "gene_names_uniprotkb": "Stmn2; Scg10; Scgn10", "gene_names_refseq": "Scg10; Scgn10; Stmn2", "protein_names_uniprotkb": "Stathmin-2; Protein SCG10; Superior cervical ganglion-10 protein", "protein_names_refseq": "stathmin-2; stathmin-like 2; superior cervical ganglion-10 protein; superiorcervical ganglia, neural specific 10", "tax_id": 10116, "disease": "motor peripheral neuropathy (Disease Ontology:DOID:2477); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); neuropathy (Disease Ontology:DOID:870)", "pathway": " (rno:84510); (R-RNO-9696273)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11882662;16368189;16618812;20106964;20621975;20802173;21215777;21297631;21471001;22673903;3272176;9012855;9525956", "class_list": "", "function": "Age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction., [RefSeq, PubMed]; CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain., [RefSeq, PubMed]; KBP-depleted PC12 cells were defective in nerve growth factor-induced differentiation and neurite outgrowth, suggesting that KBP is required for cell differentiation and neurite development., [RefSeq, PubMed]; Overexpression of SCG10 is associated with Liver Fibrosis., [RefSeq, PubMed]; Palmitoylation of stathmins 2 and 3 likely occurs at the Golgi and is crucial for their specific subcellular localization and trafficking, [RefSeq, PubMed]; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone., [UniProtKB, PubMed, PubMed, PubMed]; The microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) was found to directly interact with RGSZ1 in the yeast system, and this interaction was further verified using direct binding assays., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERH2", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031117 positive regulation of microtubule depolymerization;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P21818-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U4F4-1", "uniprot_id": [ { "id": "TM135_RAT", "url": "https://www.uniprot.org/uniprot/Q5U4F4", "type": "external" } ], "mass": 52359.0, "length": 458, "protein_name": "Transmembrane protein 135", "gene_name": "Tmem135", "organism": "Rat", "refseq_name": "transmembrane protein 135", "refseq_ac": [ { "id": "NP_001013918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013918", "type": "external" } ], "gene_names_uniprotkb": "Tmem135", "gene_names_refseq": "PMP52; RGD1309948; Tmem135", "protein_names_uniprotkb": "Transmembrane protein 135; PMP52; Peroxisomal membrane protein 52", "protein_names_refseq": "peroxisomal membrane protein 52; transmembrane protein 135", "tax_id": 10116, "disease": "", "pathway": " (rno:293098)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17522052", "class_list": "", "function": "Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (By similarity). May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L (By similarity). May be involved in peroxisome organization (PubMed:17522052)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005811 lipid droplet;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0009409 response to cold;GO:0006633 fatty acid biosynthetic process;GO:0007031 peroxisome organization;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U4F4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70277-1", "uniprot_id": [ { "id": "TRIM3_RAT", "url": "https://www.uniprot.org/uniprot/O70277", "type": "external" } ], "mass": 80796.0, "length": 744, "protein_name": "Tripartite motif-containing protein 3", "gene_name": "Trim3", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 3", "refseq_ac": [ { "id": "NP_113974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113974", "type": "external" } ], "gene_names_uniprotkb": "Trim3; Berp; Rnf22", "gene_names_refseq": "Berp; Rnf22; Trim3", "protein_names_uniprotkb": "Tripartite motif-containing protein 3; 2.3.2.27; Brain-expressed RING finger protein; RING finger protein 22", "protein_names_refseq": "brain-expressed RING finger protein; ring finger protein 22; tripartite motif protein 3; tripartite motif-containing protein 3", "tax_id": 10116, "disease": "autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274); autosomal recessive limb-girdle muscular dystrophy type 2H (Disease Ontology:DOID:0110282); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:83616)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10391919;10673389;20352094;22673903;38843836", "class_list": "", "function": "E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:20352094). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (PubMed:20352094). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3. In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Postsynaptic scaffold GKAP is degraded and dendritic spine morphology is regulated by the TRIM3 ubiquitin ligase in rat hippocampal neurons Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0030425 dendrite", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0015031 protein transport;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O70277-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQK4-1", "uniprot_id": [ { "id": "UIMC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQK4", "type": "external" } ], "mass": 80381.0, "length": 726, "protein_name": "BRCA1-A complex subunit RAP80", "gene_name": "Uimc1", "organism": "Rat", "refseq_name": "BRCA1-A complex subunit RAP80", "refseq_ac": [ { "id": "NP_001013906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013906", "type": "external" } ], "gene_names_uniprotkb": "Uimc1; Rap80", "gene_names_refseq": "RGD1307009; Uimc1", "protein_names_uniprotkb": "BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1", "protein_names_refseq": "BRCA1-A complex subunit RAP80; receptor-associated protein 80; ubiquitin interaction motif-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290997); (R-RNO-5689901); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0046965 nuclear retinoid X receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0070531 BRCA1-A complex;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811X6-1", "uniprot_id": [ { "id": "CRYL1_RAT", "url": "https://www.uniprot.org/uniprot/Q811X6", "type": "external" } ], "mass": 35341.0, "length": 319, "protein_name": "Lambda-crystallin homolog", "gene_name": "Cryl1", "organism": "Rat", "refseq_name": "lambda-crystallin homolog", "refseq_ac": [ { "id": "NP_786933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786933", "type": "external" } ], "gene_names_uniprotkb": "Cryl1; Cry", "gene_names_refseq": "Cryl1", "protein_names_uniprotkb": "Lambda-crystallin homolog; 1.1.1.45; Gul3DH; L-gulonate 3-dehydrogenase", "protein_names_refseq": "L-gulonate 3-dehydrogenase; crystallin, lamda 1; gul3DH; lambda-crystallin homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290277); (R-RNO-5661270)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12527201;22673903", "class_list": "", "function": "Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate (By similarity). It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate (By similarity). Utilizes NAD as the sole cosubstrate and shows no activity with NADP (By similarity)., [UniProtKB, UniProtKB]; Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate. Utilizes NAD as the sole cosubstrate and shows no activity with NADP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0050104 L-gulonate 3-dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q811X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6F6B3-1", "uniprot_id": [ { "id": "TANC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6F6B3", "type": "external" } ], "mass": 200507.0, "length": 1849, "protein_name": "Protein TANC1", "gene_name": "Tanc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tanc1; Tanc", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein TANC1; TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "intellectual developmental disorder with autistic features and language delay, with or without seizures (Disease Ontology:DOID:0081430)", "pathway": " (rno:311055)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15673434;18930710;22673903", "class_list": "", "function": "May be a scaffold component in the postsynaptic density., [UniProtKB]; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0008542 visual learning;GO:0007520 myoblast fusion;GO:0097062 dendritic spine maintenance;GO:0099175 regulation of postsynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6F6B3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJU3-1", "uniprot_id": [ { "id": "SAM14_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJU3", "type": "external" } ], "mass": 45196.0, "length": 417, "protein_name": "Sterile alpha motif domain-containing protein 14", "gene_name": "Samd14", "organism": "Rat", "refseq_name": "sterile alpha motif domain-containing protein 14", "refseq_ac": [ { "id": "NP_001020137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020137", "type": "external" } ], "gene_names_uniprotkb": "Samd14", "gene_names_refseq": "RGD1306138; Samd14", "protein_names_uniprotkb": "Sterile alpha motif domain-containing protein 14; SAM domain-containing protein 14", "protein_names_refseq": "SAM domain-containing protein 14; sterile alpha motif domain-containing protein 14", "tax_id": 10116, "disease": "", "pathway": " (rno:287637)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton;GO:0030425 dendrite", "go_biological_process": "GO:0007015 actin filament organization;GO:0019722 calcium-mediated signaling;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84109-1", "uniprot_id": [ { "id": "SRBS1_RAT", "url": "https://www.uniprot.org/uniprot/P84109", "type": "external" } ], "mass": 4107.0, "length": 35, "protein_name": "Sorbin and SH3 domain-containing protein 1", "gene_name": "Sorbs1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sorbs1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorbin and SH3 domain-containing protein 1; Ponsin; SH3P12", "protein_names_refseq": "", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10085297;22673903;34502162", "class_list": "", "function": "Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0095500 acetylcholine receptor signaling pathway;GO:0046889 positive regulation of lipid biosynthetic process;GO:0033993 response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P84109-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2L0-1", "uniprot_id": [ { "id": "VDAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2L0", "type": "external" } ], "mass": 30756.0, "length": 283, "protein_name": "Non-selective voltage-gated ion channel VDAC1", "gene_name": "Vdac1", "organism": "Rat", "refseq_name": "non-selective voltage-gated ion channel VDAC1", "refseq_ac": [ { "id": "NP_112643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112643", "type": "external" } ], "gene_names_uniprotkb": "Vdac1; VDAC", "gene_names_refseq": "Vdac1", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; VDAC-1; Voltage-dependent anion-selective channel protein 1; rVDAC1", "protein_names_refseq": "VDAC-1; non-selective voltage-gated ion channel VDAC1; outer mitochondrial membrane protein porin 1; rVDAC1; voltage-dependent anion-selective channel protein 1", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:83529); (R-RNO-5205685); (R-RNO-5689880); (R-RNO-70268)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10998068;11485562;17178908;17478130;22673903;23132757;25628567;26446791;27213235;32574643;33328613;33675282;34502162;35449127;35563877;36755387;36816741;450112;9714728", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of VDAC1 Rescues Abeta 1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/beta-Catenin Pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:11485562). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (PubMed:450112). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:25628567). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death., [RefSeq, PubMed]; VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism. Publication Status: Online-Only, [RefSeq, PubMed]; VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway., [RefSeq, PubMed]; VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A1L125;Q3MHT8;Q5M944;Q5M972;Q6IN28;Q6P9W9", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005262 calcium channel activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0006869 lipid transport;GO:0007612 learning;GO:0030855 epithelial cell differentiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9Z2L0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63047-1", "uniprot_id": [ { "id": "ST4A1_RAT", "url": "https://www.uniprot.org/uniprot/P63047", "type": "external" } ], "mass": 33054.0, "length": 284, "protein_name": "Sulfotransferase 4A1", "gene_name": "Sult4a1", "organism": "Rat", "refseq_name": "sulfotransferase 4A1", "refseq_ac": [ { "id": "NP_113829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113829", "type": "external" } ], "gene_names_uniprotkb": "Sult4a1; Sultx3", "gene_names_refseq": "ST4A1; Sult4a1; Sulta41; Sultx3", "protein_names_uniprotkb": "Sulfotransferase 4A1; 2.8.2.-; Brain sulfotransferase-like protein; NST; Nervous system sulfotransferase; ST4A1; rBR-STL", "protein_names_refseq": "NST; brain sulfotransferase-like protein; nervous system sulfotransferase; rBR-STL; sulfotransferase 4A1; sulfotransferase-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:58953); (R-RNO-156584)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10698717;22673903", "class_list": "", "function": "Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88872;Q91XS5;Q9CWY7;Q9DC97", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0140059 dendrite arborization;GO:0008202 steroid metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63047-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1N3-1", "uniprot_id": [ { "id": "S4A7_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1N3", "type": "external" } ], "mass": 135954.0, "length": 1218, "protein_name": "Sodium bicarbonate cotransporter 3", "gene_name": "Slc4a7", "organism": "Rat", "refseq_name": "sodium bicarbonate cotransporter 3 isoform 3", "refseq_ac": [ { "id": "NP_001257790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257790", "type": "external" } ], "gene_names_uniprotkb": "Slc4a7; Nbc2; Nbc3; Nbcn1; Nbc", "gene_names_refseq": "NBC3; NBCn1; Slc4a7", "protein_names_uniprotkb": "Sodium bicarbonate cotransporter 3; Electroneutral sodium bicarbonate cotransporter 1; NBC-like protein; Solute carrier family 4 member 7", "protein_names_refseq": "NBC-like protein; electroneutral sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter 3 isoform 3; sodium bicarbonate cotransporter 3; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-G; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-I; solute carrier family 4 sodium bicarbonate cotransporter member 7 variant NBCn1-J; solute carrier family 4, sodium bicarbonate cotransporter, member 7", "tax_id": 10116, "disease": "Usher syndrome type 2C (Disease Ontology:DOID:0110839); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:117955); (R-RNO-425381); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9035034)", "pathway_count": 5, "publication_count": 14, "publication_id_list": "10662737;10850716;10975418;11053051;12403779;14673192;15075186;15718246;16126812;16301216;22673903;28087731;29743600;37039101", "class_list": "", "function": "Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia., [RefSeq, PubMed]; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10850716, PubMed:14673192, PubMed:15075186). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (By similarity). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; The finding of a genotypic influence on SLC4A7 expression and pHi regulation in vascular smooth muscle cells provides an insight into the molecular mechanism underlying the association of variation at the SLC4A7 locus with blood pressure, [RefSeq, PubMed]; Trafficking, localization and degradation of the Na(+),HCO3(-) co-transporter NBCn1 in kidney and breast epithelial cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD5;Q9R1L1", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0090383 phagosome acidification;GO:0055085 transmembrane transport;GO:0007601 visual perception;GO:0071363 cellular response to growth factor stimulus;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R1N3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LSG8-1", "uniprot_id": [ { "id": "VPS50_RAT", "url": "https://www.uniprot.org/uniprot/F1LSG8", "type": "external" } ], "mass": 111188.0, "length": 964, "protein_name": "Syndetin", "gene_name": "Vps50", "organism": "Rat", "refseq_name": "syndetin", "refseq_ac": [ { "id": "NP_001166982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166982", "type": "external" } ], "gene_names_uniprotkb": "Vps50; Ccdc132", "gene_names_refseq": "Ccdc132; RGD1304751; Vps50", "protein_names_uniprotkb": "Syndetin; Coiled-coil domain-containing protein 132; EARP/GARPII complex subunit VPS50", "protein_names_refseq": "EARP/GARPII complex subunit VPS50; VPS50 EARP/GARPII complex subunit; coiled-coil domain containing 132; coiled-coil domain-containing protein 132-like; coiled-coil domain-containing protein 132; syndetin-like; syndetin", "tax_id": 10116, "disease": "", "pathway": " (rno:312083)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22673903;25799061;27191843;27440922;31721635", "class_list": "", "function": "Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:1990745 EARP complex;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1LSG8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35280-1", "uniprot_id": [ { "id": "RAB8A_RAT", "url": "https://www.uniprot.org/uniprot/P35280", "type": "external" } ], "mass": 23668.0, "length": 207, "protein_name": "Ras-related protein Rab-8A", "gene_name": "Rab8a", "organism": "Rat", "refseq_name": "ras-related protein Rab-8A", "refseq_ac": [ { "id": "NP_446450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446450", "type": "external" } ], "gene_names_uniprotkb": "Rab8a; Rab8", "gene_names_refseq": "Mel; Rab8a; Rab8", "protein_names_uniprotkb": "Ras-related protein Rab-8A; 3.6.5.2", "protein_names_refseq": "mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; ras-related protein Rab-8A", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (rno:117103); (R-RNO-2565942); (R-RNO-5620912); (R-RNO-5620916); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "1313420;21041651;22673903;28005071;36800997;38691557", "class_list": "", "function": "Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle., [UniProtKB, UniProtKB]; Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle., [RefSeq, PubMed]; Rab8a or Rab11a might be involved in the formation of tunneling nanotubes structures in the peripheral nerve system. Publication Status: Online-Only, [RefSeq, PubMed]; Rab8a/SNARE complex activation promotes vesicle anchoring and transport in spinal astrocytes to drive neuropathic pain. Erratum:[Biomol Biomed. 2025 Jun 12;25(11):2585. doi: 10.17305/bb.2025.12773. PMID: 40511799] Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization (By similarity). Also involved in membrane trafficking to the cilium and ciliogenesis (By similarity). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (PubMed:21041651). Involved in autophagy (By similarity). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (By similarity). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B8Q4;Q6DKL2", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0048210 Golgi vesicle fusion to target membrane;GO:0051223 regulation of protein transport;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35280-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXJ0-1", "uniprot_id": [ { "id": "TTL_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXJ0", "type": "external" } ], "mass": 43118.0, "length": 377, "protein_name": "Tubulin--tyrosine ligase", "gene_name": "Ttl", "organism": "Rat", "refseq_name": "tubulin--tyrosine ligase", "refseq_ac": [ { "id": "NP_612545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612545", "type": "external" } ], "gene_names_uniprotkb": "Ttl", "gene_names_refseq": "Ttl", "protein_names_uniprotkb": "Tubulin--tyrosine ligase; 6.3.2.25; TTL", "protein_names_refseq": "tubulin--tyrosine ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:171572)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12512949;9108330", "class_list": "", "function": "Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1E5", "ec_number_list": [ { "id": "6.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0004835 tubulin-tyrosine ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005876 spindle microtubule", "go_biological_process": "GO:0090235 regulation of metaphase plate congression;GO:0043687 post-translational protein modification;GO:0045931 positive regulation of mitotic cell cycle;GO:0030516 regulation of axon extension;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QXJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02767-1", "uniprot_id": [ { "id": "TTHY_RAT", "url": "https://www.uniprot.org/uniprot/P02767", "type": "external" } ], "mass": 15720.0, "length": 147, "protein_name": "Transthyretin", "gene_name": "Ttr", "organism": "Rat", "refseq_name": "transthyretin precursor", "refseq_ac": [ { "id": "NP_036813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036813", "type": "external" } ], "gene_names_uniprotkb": "Ttr; Tt", "gene_names_refseq": "Lr1; TT; Tbpa; Ttr", "protein_names_uniprotkb": "Transthyretin; Prealbumin; TBPA", "protein_names_refseq": "prealbumin, amyloidosis type I; transthyretin precursor", "tax_id": 10116, "disease": "hereditary systemic amyloidosis 1 (Disease Ontology:DOID:0050638); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); carpal tunnel syndrome 1 (Disease Ontology:DOID:0070466); dystransthyretinemic hyperthyroxinemia (Disease Ontology:DOID:0080219); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); lung cancer (Disease Ontology:DOID:1324); brain ischemia (Disease Ontology:DOID:2316); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); amyloidosis (Disease Ontology:DOID:9120); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24856); (R-RNO-2453902); (R-RNO-6798695); (R-RNO-975634)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "11995998;14715898;21454685;22673903;2309926;2734110;2891699;32852783;3839240;39039431;3922975;873934;9511961", "class_list": "", "function": "A low amyloidogenic E61K transthyretin mutation may cause familial amyloid polyneuropathy., [RefSeq, PubMed]; Association between rat decompression sickness resistance, transthyretin single nucleotide polymorphism, and expression: A pilot study., [RefSeq, PubMed]; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q547K9", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042562 hormone binding;GO:0044877 protein-containing complex binding;GO:0070324 thyroid hormone binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006144 purine nucleobase metabolic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P02767-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5H6-1", "uniprot_id": [ { "id": "TUTLA_RAT", "url": "https://www.uniprot.org/uniprot/P0C5H6", "type": "external" } ], "mass": 127933.0, "length": 1179, "protein_name": "Protein turtle homolog A", "gene_name": "Igsf9", "organism": "Rat", "refseq_name": "protein turtle homolog A isoform 1 precursor", "refseq_ac": [ { "id": "NP_001100667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100667", "type": "external" } ], "gene_names_uniprotkb": "Igsf9; Dasm1; Igsf9a", "gene_names_refseq": "Igsf9", "protein_names_uniprotkb": "Protein turtle homolog A; Dendrite arborization and synapse maturation protein 1; IgSF9A; Immunoglobulin superfamily member 9A", "protein_names_refseq": "dendrite arborization and synapse maturation protein 1; igSF9A; immunoglobulin superfamily member 9A; protein turtle homolog A isoform 1 precursor; protein turtle homolog A", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:304982)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15340156;15340157;22673903", "class_list": "", "function": "Functions in dendrite outgrowth and synapse maturation., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030424 axon;GO:0030425 dendrite;GO:0043005 neuron projection;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0016358 dendrite development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0090128 regulation of synapse maturation;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C5H6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q53AQ4-1", "uniprot_id": [ { "id": "TMUB1_RAT", "url": "https://www.uniprot.org/uniprot/Q53AQ4", "type": "external" } ], "mass": 26349.0, "length": 245, "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 1", "gene_name": "Tmub1", "organism": "Rat", "refseq_name": "transmembrane and ubiquitin-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_001073622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073622", "type": "external" } ], "gene_names_uniprotkb": "Tmub1; Hops", "gene_names_refseq": "Hops; Tmub1", "protein_names_uniprotkb": "Transmembrane and ubiquitin-like domain-containing protein 1; Hepatocyte odd protein shuttling protein", "protein_names_refseq": "hepatocyte odd protein shuttling protein; transmembrane and ubiquitin-like domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362301)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16014383;18418082;18665261;22426572;22890319;24240191;29344642;29777440;29967478", "class_list": "", "function": "HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm., [RefSeq, PubMed]; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (PubMed:18665261). Acts as a negative regulator of hepatocyte growth during regeneration (PubMed:22426572)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as a negative regulator of hepatocyte growth during regeneration., [UniProtKB, UniProtKB, UniProtKB]; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-27a/b regulates hepatocyte proliferation by controlling posttranscriptional modification of Tmub1 during liver regeneration., [RefSeq, PubMed]; TMUB1 regulates hepatocyte proliferation by interacting with CAML and further interferes with the binding of CAML to cyclophilin B. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to a group of integral ubiquitin-like domain containing proteins that are involved in a range of cellular processes. In mouse, the protein exists in uncleaved transmembrane forms as well as a cleaved form that shuttles between the nucleus and cytoplasm. During liver regeneration in rat, it has been shown that the protein shuttles from the cytoplasm to the nucleus to inhibit hepatocyte proliferation. Homozygous null mutant mice display normal development and physiology but exhibit a strong increase in locomoter activity during the dark phase of the light:dark cycle, indicating a function in behavioral regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]; The transcriptional profile and potential biological processes affected by Tmub1 expression in hepatocytes have been reported., [RefSeq, PubMed]; Tmub1 plays a negative role in IL-6-induced hepatocyte proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005813 centrosome;GO:0045211 postsynaptic membrane;GO:0098944 postsynaptic recycling endosome membrane;GO:0055037 recycling endosome", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q53AQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63615-1", "uniprot_id": [ { "id": "VP33A_RAT", "url": "https://www.uniprot.org/uniprot/Q63615", "type": "external" } ], "mass": 67514.0, "length": 597, "protein_name": "Vacuolar protein sorting-associated protein 33A", "gene_name": "Vps33a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vps33a", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33A; r-vps33a", "protein_names_refseq": "", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (rno:65081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11382755;8996080", "class_list": "", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z325-1", "uniprot_id": [ { "id": "DPM2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z325", "type": "external" } ], "mass": 9344.0, "length": 84, "protein_name": "Dolichol phosphate-mannose biosynthesis regulatory protein", "gene_name": "Dpm2; Pip5kl1", "organism": "Rat", "refseq_name": "dolichol phosphate-mannose biosynthesis regulatory protein", "refseq_ac": [ { "id": "NP_062125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062125", "type": "external" } ], "gene_names_uniprotkb": "Dpm2; Pip5kl1; Pip5kl1", "gene_names_refseq": "Dpm2", "protein_names_uniprotkb": "Dolichol phosphate-mannose biosynthesis regulatory protein; DPM synthase subunit 2; Dolichol-phosphate mannose synthase subunit 2", "protein_names_refseq": "DPM synthase subunit 2; dolichol phosphate-mannose biosynthesis regulatory protein; dolichol-phosphate (beta-D) mannosyltransferase 2; dolichol-phosphate mannose synthase subunit 2; dolichol-phosphate mannosyltransferase 2; dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit", "tax_id": 10116, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 19 (Disease Ontology:DOID:0070049); exudative vitreoretinopathy 7 (Disease Ontology:DOID:0080264); congenital disorder of glycosylation Iu (Disease Ontology:DOID:0080571); traumatic brain injury (Disease Ontology:DOID:0081292); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); granulosa cell tumor (Disease Ontology:DOID:2999); carcinoma (Disease Ontology:DOID:305); teratoma (Disease Ontology:DOID:3307); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung carcinoma (Disease Ontology:DOID:3905); lung squamous cell carcinoma (Disease Ontology:DOID:3907); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); fibrolamellar carcinoma (Disease Ontology:DOID:5015); pilomatrixoma (Disease Ontology:DOID:5374); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); neuropathy (Disease Ontology:DOID:870); in situ carcinoma (Disease Ontology:DOID:8719); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29640); (R-RNO-162699); (R-RNO-162710)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9724629", "class_list": "", "function": "Regulates the biosynthesis of dolichol phosphate-mannose (PubMed:9724629). Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1 (PubMed:9724629). Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex., [UniProtKB, UniProtKB, UniProtKB]; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0008047 enzyme activator activity;GO:0030234 enzyme regulator activity;GO:0005524 ATP binding;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006506 GPI anchor biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process;GO:0046488 phosphatidylinositol metabolic process;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z325-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6L0-1", "uniprot_id": [ { "id": "MGLYR_RAT", "url": "https://www.uniprot.org/uniprot/D4A6L0", "type": "external" } ], "mass": 134459.0, "length": 1202, "protein_name": "Metabotropic glycine receptor", "gene_name": "Gpr158", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpr158", "gene_names_refseq": "", "protein_names_uniprotkb": "Metabotropic glycine receptor; G protein-coupled receptor 158; mGlyR", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22673903;30290982;38843836", "class_list": "", "function": "Metabotropic receptor for glycine that controls synapse formation and function in the brain. Acts as an atypical G protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins. In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels. Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity. Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission (By similarity). Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability. Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4. In addition to glycine, may also act as a receptor for osteocalcin (BGLAP) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0008047 enzyme activator activity;GO:0160079 G protein-coupled glycine receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0050890 cognition;GO:0072659 protein localization to plasma membrane;GO:0007420 brain development;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D4A6L0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYQ3-1", "uniprot_id": [ { "id": "SYFM_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYQ3", "type": "external" } ], "mass": 55165.0, "length": 472, "protein_name": "Phenylalanine--tRNA ligase, mitochondrial", "gene_name": "Fars2", "organism": "Rat", "refseq_name": "phenylalanine--tRNA ligase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001013157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013157", "type": "external" } ], "gene_names_uniprotkb": "Fars2; Fars1", "gene_names_refseq": "Fars1; Fars2", "protein_names_uniprotkb": "Phenylalanine--tRNA ligase, mitochondrial; 6.1.1.20; PheRS; Phenylalanyl-tRNA synthetase", "protein_names_refseq": "pheRS; phenylalanine--tRNA ligase, mitochondrial isoform 1; phenylalanine--tRNA ligase, mitochondrial; phenylalanine-tRNA synthetase 1 (mitochondrial); phenylalanine-tRNA synthetase 2 (mitochondrial); phenylalanyl-tRNA synthetase, mitochondrial", "tax_id": 10116, "disease": "hereditary spastic paraplegia 77 (Disease Ontology:DOID:0110822); combined oxidative phosphorylation deficiency 14 (Disease Ontology:DOID:0111477); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202)", "pathway": " (rno:306879)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26553276;38362779", "class_list": "", "function": "FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System., [RefSeq, PubMed]; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004826 phenylalanine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0008033 tRNA processing;GO:0006432 phenylalanyl-tRNA aminoacylation;GO:0006412 translation;GO:0043039 tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYQ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C219-1", "uniprot_id": [ { "id": "SLMAP_RAT", "url": "https://www.uniprot.org/uniprot/P0C219", "type": "external" } ], "mass": 98224.0, "length": 858, "protein_name": "Sarcolemmal membrane-associated protein", "gene_name": "Slmap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slmap", "gene_names_refseq": "", "protein_names_uniprotkb": "Sarcolemmal membrane-associated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15591093;22673903", "class_list": "", "function": "Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (By similarity). May play a role during myoblast fusion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0072659 protein localization to plasma membrane;GO:0035331 negative regulation of hippo signaling;GO:1902305 regulation of sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C219-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56603-1", "uniprot_id": [ { "id": "SCAM1_RAT", "url": "https://www.uniprot.org/uniprot/P56603", "type": "external" } ], "mass": 37999.0, "length": 338, "protein_name": "Secretory carrier-associated membrane protein 1", "gene_name": "Scamp1", "organism": "Rat", "refseq_name": "secretory carrier-associated membrane protein 1", "refseq_ac": [ { "id": "NP_001094106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094106", "type": "external" } ], "gene_names_uniprotkb": "Scamp1; Scamp", "gene_names_refseq": "Scamp1", "protein_names_uniprotkb": "Secretory carrier-associated membrane protein 1; SCAMP 37; Secretory carrier membrane protein 1", "protein_names_refseq": "SCAMP 37; secretory carrier-associated membrane protein 1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:29521); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10777571;16105885;18171723;21272170;22673903;8404846", "class_list": "", "function": "Data suggest that SCAMP1's apparent dual role in facilitating dilation and closure of fusion pores implicates its function in exo-endocytic coupling and in the regulation of partial secretion., [RefSeq, PubMed]; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface., [UniProtKB, PubMed]; SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons., [RefSeq, PubMed]; SCAMPs travel between the cell surface and internal recycling systems, and form a mosaic with individual isoforms marking distinct pathways and functioning as trafficking machinery at sites of vesicle formation and fusion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0043195 terminal bouton;GO:0045202 synapse;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56603-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55164-1", "uniprot_id": [ { "id": "MPDZ_RAT", "url": "https://www.uniprot.org/uniprot/O55164", "type": "external" } ], "mass": 218592.0, "length": 2054, "protein_name": "Multiple PDZ domain protein", "gene_name": "Mpdz", "organism": "Rat", "refseq_name": "multiple PDZ domain protein isoform 2", "refseq_ac": [ { "id": "NP_062069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062069", "type": "external" } ], "gene_names_uniprotkb": "Mpdz; Mupp1", "gene_names_refseq": "Mpdz", "protein_names_uniprotkb": "Multiple PDZ domain protein; Multi-PDZ domain protein 1", "protein_names_refseq": "multi-PDZ domain protein 1; multiple PDZ domain protein isoform 2; multiple PDZ domain protein", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:29365)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "11000240;11150294;12403818;15312654;15863617;18417361;19934217;22673903;25977097;9537516", "class_list": "", "function": "CaMKIIalpha interacts with MUPP1 in spermatozoa to prevents spontaneous acrosomal exocytosis., [RefSeq, PubMed]; In the dendrite and synapse, MUPP1 transports GPR37., [RefSeq, PubMed]; MUPP1-SynGAPalpha complex dissociation triggers a mechanism for AMPAR enhancement that is distinct from activity-induced long term potentiation, [RefSeq, PubMed]; Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (PubMed:15312654). Promotes clustering of HT2RC at the cell surface (PubMed:11150294)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0014069 postsynaptic density", "go_biological_process": "GO:0120192 tight junction assembly;GO:0006886 intracellular protein transport;GO:0007155 cell adhesion;GO:0016358 dendrite development;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O55164-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04774-1", "uniprot_id": [ { "id": "SCN1A_RAT", "url": "https://www.uniprot.org/uniprot/P04774", "type": "external" } ], "mass": 228770.0, "length": 2009, "protein_name": "Sodium channel protein type 1 subunit alpha", "gene_name": "Scn1a; Scn3a", "organism": "Rat", "refseq_name": "sodium channel protein type 1 subunit alpha", "refseq_ac": [ { "id": "NP_110502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110502", "type": "external" } ], "gene_names_uniprotkb": "Scn1a; Scn3a", "gene_names_refseq": "Scn1a", "protein_names_uniprotkb": "Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1", "protein_names_refseq": "sodium channel protein type 1 subunit alpha-like; sodium channel protein type 1 subunit alpha; sodium channel protein type I subunit alpha; sodium channel protein, brain I subunit alpha; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy 6B (Disease Ontology:DOID:0070379); Dravet syndrome (Disease Ontology:DOID:0080422); familial hemiplegic migraine 3 (Disease Ontology:DOID:0111183); generalized epilepsy with febrile seizures plus 2 (Disease Ontology:DOID:0111294); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (rno:81574)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1658739;20131913;22673903;2442385;24497506;32318899;32377688;33045260;3754035", "class_list": "", "function": "Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior., [RefSeq, PubMed]; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits. Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy., [RefSeq, PubMed]; Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0014704 intercalated disc", "go_biological_process": "GO:0019228 neuronal action potential;GO:0042391 regulation of membrane potential;GO:0001508 action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P04774-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62839-1", "uniprot_id": [ { "id": "GOGA2_RAT", "url": "https://www.uniprot.org/uniprot/Q62839", "type": "external" } ], "mass": 112872.0, "length": 998, "protein_name": "Golgin subfamily A member 2", "gene_name": "Golga2", "organism": "Rat", "refseq_name": "golgin subfamily A member 2", "refseq_ac": [ { "id": "NP_072118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072118", "type": "external" } ], "gene_names_uniprotkb": "Golga2", "gene_names_refseq": "Gm130; Golga2", "protein_names_uniprotkb": "Golgin subfamily A member 2; 130 kDa cis-Golgi matrix protein; GM130", "protein_names_refseq": "130 kDa cis-Golgi matrix protein; cis-Golgi matrix protein GM130; golgi autoantigen, golgin subfamily a, 2; golgin subfamily A member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64528); (R-RNO-162658); (R-RNO-204005); (R-RNO-6807878)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10679020;10744704;10769027;11035033;11739401;14742712;18167358;20197635;20699666;25787021;26165940;8557739;9150144;9346242;9628863;9753325", "class_list": "", "function": "Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (PubMed:20197635, PubMed:9150144). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:10679020, PubMed:11035033, PubMed:18167358). Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (PubMed:9753325). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (By similarity). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (By similarity). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LSS0", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000922 spindle pole;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0051289 protein homotetramerization;GO:0090307 mitotic spindle assembly;GO:0009101 glycoprotein biosynthetic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q62839-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62740-1", "uniprot_id": [ { "id": "SPP24_RAT", "url": "https://www.uniprot.org/uniprot/Q62740", "type": "external" } ], "mass": 23170.0, "length": 203, "protein_name": "Secreted phosphoprotein 24", "gene_name": "Spp2", "organism": "Rat", "refseq_name": "secreted phosphoprotein 24 precursor", "refseq_ac": [ { "id": "NP_446029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446029", "type": "external" } ], "gene_names_uniprotkb": "Spp2; Spp24", "gene_names_refseq": "Spp2", "protein_names_uniprotkb": "Secreted phosphoprotein 24; Secreted phosphoprotein 2; Spp-24", "protein_names_refseq": "secreted phosphoprotein 2, 24kDa; secreted phosphoprotein 24 precursor; secreted phosphoprotein 24; spp-24", "tax_id": 10116, "disease": "", "pathway": " (rno:94168); (R-RNO-114608); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Could coordinate an aspect of bone turnover., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M874", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046849 bone remodeling;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62740-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62770-1", "uniprot_id": [ { "id": "UN13C_RAT", "url": "https://www.uniprot.org/uniprot/Q62770", "type": "external" } ], "mass": 249136.0, "length": 2204, "protein_name": "Protein unc-13 homolog C", "gene_name": "Unc13c", "organism": "Rat", "refseq_name": "protein unc-13 homolog C", "refseq_ac": [ { "id": "NP_775169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775169", "type": "external" } ], "gene_names_uniprotkb": "Unc13c; Unc13h3", "gene_names_refseq": "Unc13c; Unc13h3", "protein_names_uniprotkb": "Protein unc-13 homolog C; Munc13-3", "protein_names_refseq": "Munc13-3; protein unc-13 homolog C-like; protein unc-13 homolog C", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:286931)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;7559667;9895278", "class_list": "", "function": "May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0046928 regulation of neurotransmitter secretion;GO:0016079 synaptic vesicle exocytosis;GO:0031914 negative regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62770-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50411-1", "uniprot_id": [ { "id": "IPP2_RAT", "url": "https://www.uniprot.org/uniprot/P50411", "type": "external" } ], "mass": 23071.0, "length": 205, "protein_name": "Protein phosphatase inhibitor 2", "gene_name": "Ppp1r2", "organism": "Rat", "refseq_name": "protein phosphatase inhibitor 2", "refseq_ac": [ { "id": "NP_620178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620178", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r2; Ipp2", "gene_names_refseq": "IPP-2; Ppp1r2", "protein_names_uniprotkb": "Protein phosphatase inhibitor 2; IPP-2", "protein_names_refseq": "phosphatase inhibitor 2; protein phosphatase 1, regulatory subunit 2; protein phosphatase inhibitor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:192361)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;23825423;7669271", "class_list": "", "function": "A novel calcium-induced IPP-2 activation pathway is found that is critical for homeostatic synaptic plasticity., [RefSeq, PubMed]; Inhibitor of protein-phosphatase 1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56A32", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0004864 protein phosphatase inhibitor activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0030426 growth cone;GO:0043197 dendritic spine", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0005977 glycogen metabolic process;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN27-1", "uniprot_id": [ { "id": "TF2H2_RAT", "url": "https://www.uniprot.org/uniprot/A0JN27", "type": "external" } ], "mass": 44703.0, "length": 396, "protein_name": "General transcription factor IIH subunit 2", "gene_name": "Gtf2h2", "organism": "Rat", "refseq_name": "general transcription factor IIH subunit 2", "refseq_ac": [ { "id": "NP_001070896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070896", "type": "external" } ], "gene_names_uniprotkb": "Gtf2h2", "gene_names_refseq": "BTF2 p44; Gtf2h2", "protein_names_uniprotkb": "General transcription factor IIH subunit 2; BTF2 p44; Basic transcription factor 2 44 kDa subunit; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit", "protein_names_refseq": "BTF2-p44; TFIIH basal transcription factor complex p44 subunit; basic transcription factor 2 44 kDa subunit; general transcription factor IIH subunit 2; general transcription factor IIH, polypeptide 2", "tax_id": 10116, "disease": "", "pathway": " (rno:294693); (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075)", "pathway_count": 20, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000438 core TFIIH complex portion of holo TFIIH complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0002031 G protein-coupled receptor internalization;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JN27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37090-1", "uniprot_id": [ { "id": "SCNNB_RAT", "url": "https://www.uniprot.org/uniprot/P37090", "type": "external" } ], "mass": 71995.0, "length": 638, "protein_name": "Epithelial sodium channel subunit beta", "gene_name": "Scnn1b", "organism": "Rat", "refseq_name": "epithelial sodium channel subunit beta", "refseq_ac": [ { "id": "NP_036780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036780", "type": "external" } ], "gene_names_uniprotkb": "Scnn1b", "gene_names_refseq": "RNENACB; Scnn1b", "protein_names_uniprotkb": "Epithelial sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta-ENaC; Beta-NaCH; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB", "protein_names_refseq": "SCNEB; amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated, type I, beta", "tax_id": 10116, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 1 (Disease Ontology:DOID:0080526); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:24767); (R-RNO-2672351); (R-RNO-9730628)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "11323714;11352848;11773057;12654927;24553299;26297031;27215035;27941075;30659401;8107805;8665844;9039092;9118951;9351815;9501257", "class_list": "", "function": "Decreased expression of Scnn1b/g and activation of ENaC could be involved in attenuation of the aortic baroreceptor sensitivity in congestive heart failure., [RefSeq, PubMed]; Deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP., [RefSeq, PubMed]; Suggest that beta-ENaC mediates cytotrophoblast migration and increasing beta-ENaC expression by HO-1 induction enhances migration., [RefSeq, PubMed]; The discovered changes in the expression level of catechol-o-methyltransferase , mineralocorticoid receptor , and b-subunit of epithelial sodium channel confirm their involvement in increased sympathetic stimulation of the of hypertensive rats, [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:8107805, PubMed:9118951). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:11352848, PubMed:11773057, PubMed:9118951). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (By similarity). This subunit is not essential for ENaC function in airway surface liquid homeostasis and proper mucus clearance (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O09183", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0042045 epithelial fluid transport;GO:0002283 neutrophil activation involved in immune response;GO:0001666 response to hypoxia;GO:0008217 regulation of blood pressure;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P37090-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQG6-1", "uniprot_id": [ { "id": "KDIS_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQG6", "type": "external" } ], "mass": 195716.0, "length": 1762, "protein_name": "Kinase D-interacting substrate of 220 kDa", "gene_name": "Kidins220", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kidins220; Arms", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:116478); (R-RNO-170984); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "10998417;11150334;15167895;15378608;15939763;17724123;22673903;38843836", "class_list": "", "function": "Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 21, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERD4", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030165 PDZ domain binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0010976 positive regulation of neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0048813 dendrite morphogenesis;GO:0038180 nerve growth factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9EQG6-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63531-1", "uniprot_id": [ { "id": "KS6A1_RAT", "url": "https://www.uniprot.org/uniprot/Q63531", "type": "external" } ], "mass": 82883.0, "length": 735, "protein_name": "Ribosomal protein S6 kinase alpha-1", "gene_name": "Rps6ka1", "organism": "Rat", "refseq_name": "ribosomal protein S6 kinase alpha-1", "refseq_ac": [ { "id": "NP_112369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112369", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka1; Mapkapk1a; Rsk1", "gene_names_refseq": "Rps6ka1; S6K-alpha 1", "protein_names_uniprotkb": "Ribosomal protein S6 kinase alpha-1; 2.7.11.1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1; Ribosomal S6 kinase 1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K", "protein_names_refseq": "90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; MAPKAPK1A; RSK-1; S6 protein kinase (Rsk-1); S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; pp90RSK1; ribosomal S6 kinase 1; ribosomal protein S6 kinase alpha-1; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, polypeptide A1", "tax_id": 10116, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (rno:81771); (R-RNO-198753); (R-RNO-199920); (R-RNO-2559582); (R-RNO-442742); (R-RNO-444257); (R-RNO-881907); (R-RNO-9856649)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "10480933;14504289;15117958;24330599;26022182;31505737;31582215;7688567", "class_list": "", "function": "FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP Expression via Regulation of ChREBP in Pancreatic beta Cells. Publication Status: Online-Only, [RefSeq, PubMed]; In the native GH3 cell system, ERK and RSK are involved in the pathway linking TRH receptor to r-ERG channel inhibition, but additional components must participate to cause such inhibition., [RefSeq, PubMed]; Our findings demonstrate a hitherto unrecognized mechanism of c-Jun N-terminal kinase-P90RSK in mediating synergistic neurite outgrowth Publication Status: Online-Only, [RefSeq, PubMed]; Repeated bouts of resistance training desensitized ERK1/2 and p38 MAPK, subsequently attenuating p90RSK phosphorylation in a rat model, [RefSeq, PubMed]; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (By similarity). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:15117958). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (By similarity). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (By similarity). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (By similarity). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (By similarity). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (By similarity). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (By similarity). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (By similarity). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (By similarity). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:14504289). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (By similarity). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M5M3-1", "uniprot_id": [ { "id": "TEX14_RAT", "url": "https://www.uniprot.org/uniprot/F1M5M3", "type": "external" } ], "mass": 162407.0, "length": 1443, "protein_name": "Inactive serine/threonine-protein kinase TEX14", "gene_name": "Tex14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tex14", "gene_names_refseq": "", "protein_names_uniprotkb": "Inactive serine/threonine-protein kinase TEX14; Testis-expressed sequence 14 protein; Testis-expressed sequence 14", "protein_names_refseq": "", "tax_id": 10116, "disease": "spermatogenic failure 23 (Disease Ontology:DOID:0070181)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;41018975", "class_list": "", "function": "Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0000776 kinetochore;GO:0030496 midbody", "go_biological_process": "GO:0043063 intercellular bridge organization;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:1990830 cellular response to leukemia inhibitory factor;GO:0051306 mitotic sister chromatid separation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1M5M3-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1H5H1-1", "uniprot_id": [ { "id": "SELT_RAT", "url": "https://www.uniprot.org/uniprot/Q1H5H1", "type": "external" } ], "mass": 22292.0, "length": 195, "protein_name": "Thioredoxin reductase-like selenoprotein T", "gene_name": "Selenot", "organism": "Rat", "refseq_name": "thioredoxin reductase-like selenoprotein T precursor", "refseq_ac": [ { "id": "NP_001014275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014275", "type": "external" } ], "gene_names_uniprotkb": "Selenot; Selt", "gene_names_refseq": "Selenot", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T; 1.8.1.9; SelT", "protein_names_refseq": "thioredoxin reductase-like enzyme; thioredoxin reductase-like selenoprotein T precursor; thioredoxin reductase-like selenoprotein T", "tax_id": 10116, "disease": "", "pathway": " (rno:365802)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "18198219;21896670;26280902;26779623;26866473;30267375;32686857;38643121", "class_list": "", "function": "PACAP and cAMP-activated AMPK-PGC-1alpha/NRF-1 cascade is critical for the coupling of oxidative stress tolerance, via SELENOT gene expression, and mitochondrial biogenesis in order to achieve PC12 cell differentiation., [RefSeq, PubMed]; Role in the regulation of Ca(2+) homeostasis and neuroendocrine secretion in response to a cAMP-stimulating trophic factor., [RefSeq, PubMed]; Se plays a major role in regulating the contraction processes of gastric smooth muscle with the SelT., [RefSeq, PubMed]; SelT induction is associated with ontogenesis, tissue maturation, and regenerative mechanisms, indicating that this PACAP-regulated selenoprotein may play a crucial role in cell growth and activity in nervous, endocrine, and metabolic tissues., [RefSeq, PubMed]; SelT may play a major role in the mechanisms underlying the biological activity of Se in smooth muscle tissues., [RefSeq, PubMed]; Selenoprotein T protects against cisplatin-induced acute kidney injury through suppression of oxidative stress and apoptosis., [RefSeq, PubMed]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (PubMed:26866473). Protects dopaminergic neurons against oxidative stress and cell death (By similarity). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (PubMed:18198219). Plays a role in fibroblast anchorage and redox regulation (By similarity). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (PubMed:26779623). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity. Protects dopaminergic neurons against oxidative stress and cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion. Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation. In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion., [UniProtKB, UniProtKB]; The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in rat indicate a role for this gene in the regulation of calcium homeostasis and smooth muscle contraction. High induction of this gene is also associated with ontogenetic and regenerative processes in nervous, endocrine, and metabolic tissues. A pseudogene of this locus has been identified on chromosome 4. [provided by RefSeq, Aug 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0031016 pancreas development;GO:0009749 response to glucose;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q1H5H1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49616-1", "uniprot_id": [ { "id": "UPAR_RAT", "url": "https://www.uniprot.org/uniprot/P49616", "type": "external" } ], "mass": 35753.0, "length": 328, "protein_name": "Urokinase plasminogen activator surface receptor", "gene_name": "Plaur", "organism": "Rat", "refseq_name": "urokinase plasminogen activator surface receptor precursor", "refseq_ac": [ { "id": "NP_599179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599179", "type": "external" } ], "gene_names_uniprotkb": "Plaur", "gene_names_refseq": "Par; Plaur3; Plaur; uPAR-2; uPAR-3; uPAR", "protein_names_uniprotkb": "Urokinase plasminogen activator surface receptor; U-PAR; uPAR", "protein_names_refseq": "U-PAR; plasminogen activator urokinase receptor 3; urinary plasminogen activator receptor 2; urinary plasminogen activator receptor 3; urokinase plasminogen activator receptor; urokinase plasminogen activator surface receptor precursor; urokinase plasminogen activator surface receptor", "tax_id": 10116, "disease": "sinusitis (Disease Ontology:DOID:0050127); alcohol-associated liver disease (Disease Ontology:DOID:0070658); pre-eclampsia (Disease Ontology:DOID:10591); Lyme disease (Disease Ontology:DOID:11729); cardiovascular system disease (Disease Ontology:DOID:1287); disease of cellular proliferation (Disease Ontology:DOID:14566); status epilepticus (Disease Ontology:DOID:1824); hepatitis B (Disease Ontology:DOID:2043); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); melioidosis (Disease Ontology:DOID:5052); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); meningitis (Disease Ontology:DOID:9471); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:50692); (R-RNO-162791); (R-RNO-6798695); (R-RNO-75205); (R-RNO-9855719); (R-RNO-9970672)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11798065;1321734;22773570;24815166;24935436;38161044;8307160", "class_list": "", "function": "Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling., [UniProtKB, UniProtKB]; Increased postmortem PLAUR expression could serve as a biomarker to aid diagnosis of early myocardial infarction., [RefSeq, PubMed]; MicroRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury., [RefSeq, PubMed]; Rapamycin could promote podocyte migration through the up-regulation of uPAR leading to proteinuria., [RefSeq, PubMed]; Study examines the expression and function of uPAR in developing rat ventral prostates, [RefSeq, PubMed]; UPA, uPAR, MMP-2 and MMP-9 play an important role in GBM growth. Blockade of uPA and interruption of the proteolytic cascade could become a useful tool in the therapy of GBM, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O35771;P51573;Q7TN35", "ec_number_list": [], "go_molecular_function": "GO:0030377 urokinase plasminogen activator receptor activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:1905370 serine-type endopeptidase complex;GO:0098637 protein complex involved in cell-matrix adhesion", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0001934 positive regulation of protein phosphorylation;GO:0007283 spermatogenesis;GO:0030155 regulation of cell adhesion;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49616-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62985-1", "uniprot_id": [ { "id": "SH2B1_RAT", "url": "https://www.uniprot.org/uniprot/Q62985", "type": "external" } ], "mass": 79637.0, "length": 756, "protein_name": "SH2B adapter protein 1", "gene_name": "Sh2b1", "organism": "Rat", "refseq_name": "SH2B adapter protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001041645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041645", "type": "external" } ], "gene_names_uniprotkb": "Sh2b1; Sh2-b; Sh2bpsm1", "gene_names_refseq": "Sh2-b; Sh2b1; Sh2bpsm1; Sh2b", "protein_names_uniprotkb": "SH2B adapter protein 1; FceRI gamma-chain-interacting protein SH2-B; SH2 domain-containing protein 1B; SH2-B PH domain-containing signaling mediator 1", "protein_names_refseq": "SH2 domain-containing protein 1B; SH2-B PH domain-containing signaling mediator 1; SH2B adapter protein 1 isoform 2; SH2B adapter protein 1; fceRI gamma-chain-interacting protein SH2-B", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398)", "pathway": " (rno:89817); (R-RNO-1170546); (R-RNO-982772); (R-RNO-983231)", "pathway_count": 4, "publication_count": 20, "publication_id_list": "10377387;10473609;10757801;11238898;11751854;11786545;11827956;12551917;15082760;16569669;22673903;24260264;25586189;30015896;30372837;9343427;9636306;9694882;9742218;9856458", "class_list": "", "function": "Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor 1 (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF1 and PDGF-induced mitogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Findings demonstrate that SH2B1beta promotes BDNF-induced neurite outgrowth through enhancing pathways involved MEK-ERK1/2 and PI3K-AKT. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-14 2-3 p not only mitigate cardiac hypertrophy by directly inhibit the expression of gene SH2B1, but also can protect mitochondrial function in cardiac hypertrophy of vitro and vivo., [RefSeq, PubMed]; SH2B1 overexpression resulted in increased viability, reduced lactate dehydrogenase release and a reduction in the expression levels of proteins associated with the apoptotic cascade in PC12 cells under the oxygenglucose deprivation condition., [RefSeq, PubMed]; These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55072", "ec_number_list": [], "go_molecular_function": "GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:2000278 regulation of DNA biosynthetic process;GO:0035556 intracellular signal transduction;GO:0030032 lamellipodium assembly;GO:0048870 cell motility;GO:0045840 positive regulation of mitotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q62985-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35964-1", "uniprot_id": [ { "id": "SH3G1_RAT", "url": "https://www.uniprot.org/uniprot/O35964", "type": "external" } ], "mass": 41492.0, "length": 368, "protein_name": "Endophilin-A2", "gene_name": "Sh3gl1", "organism": "Rat", "refseq_name": "endophilin-A2", "refseq_ac": [ { "id": "NP_112518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112518", "type": "external" } ], "gene_names_uniprotkb": "Sh3gl1; Sh3p8", "gene_names_refseq": "SH3P8; Sh3gl1", "protein_names_uniprotkb": "Endophilin-A2; Endophilin-2; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3p8", "protein_names_refseq": "SH3 domain protein 2B; SH3 domain-containing GRB2-like 1; SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 1; endophilin-2; endophilin-A2", "tax_id": 10116, "disease": "high grade glioma (Disease Ontology:DOID:3070); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:81922); (R-RNO-182971); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "17088211;17496889;18391417;19322778;22673903;23285027;28758034;29574155;29923351;33504785;9238017", "class_list": "", "function": "EndoA2 inhibited hydrogen peroxide-induced apoptosis in H9C2 cardiomyocytes., [RefSeq, PubMed]; Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes., [RefSeq, PubMed]; Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity)., [UniProtKB, UniProtKB]; Implicated in endocytosis. May recruit other proteins to membranes with high curvature., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study demonstrates that endophilin2 does not contribute to constitutive AMPA receptor endocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006897 endocytosis;GO:0098815 modulation of excitatory postsynaptic potential;GO:0061024 membrane organization;GO:1900242 regulation of synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O35964-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09217-1", "uniprot_id": [ { "id": "KPCZ_RAT", "url": "https://www.uniprot.org/uniprot/P09217", "type": "external" } ], "mass": 67733.0, "length": 592, "protein_name": "Protein kinase C zeta type", "gene_name": "Prkcz", "organism": "Rat", "refseq_name": "protein kinase C zeta type isoform 2", "refseq_ac": [ { "id": "NP_071952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071952", "type": "external" } ], "gene_names_uniprotkb": "Prkcz; Pkcz", "gene_names_refseq": "14-3-3-zetaisoform; Pkcz; Prkcz; r14-3-3", "protein_names_uniprotkb": "Protein kinase C zeta type; 2.7.11.13; nPKC-zeta", "protein_names_refseq": "nPKC-zeta; protein kinase C zeta type isoform 2; protein kinase C zeta type", "tax_id": 10116, "disease": "carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25522); (R-RNO-2173791); (R-RNO-5218921); (R-RNO-5668599); (R-RNO-9634635)", "pathway_count": 5, "publication_count": 25, "publication_id_list": "10022904;10747026;11158308;11525734;11914719;12431995;12813044;12857744;14580237;18295358;19380482;22673903;2470089;27498875;2834397;29288797;30622166;31026567;34968669;3691811;38691529;8378304;8557035;9177193;9374484", "class_list": "", "function": "Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inactivity-induced phrenic motor facilitation requires PKCzeta activity within phrenic motor neurons., [RefSeq, PubMed]; Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance., [UniProtKB, PubMed, PubMed]; PKMzeta Maintains Remote Contextual Fear Memory by Inhibiting GluA2-Dependent AMPA Receptor Endocytosis in the Prelimbic Cortex., [RefSeq, PubMed]; PKMzeta inhibition disrupts reconsolidation and erases object recognition memory. Results also indicate that hippocampal PKMzeta acts downstream of BDNF and controls AMPAR synaptic insertion to elicit reconsolidation and suggest that blocking PKMzeta activity during this process deletes active object recognition memory., [RefSeq, PubMed]; Protein Kinase M zeta is activated in prelimbic cortex during consolidation of memory., [RefSeq, PubMed]; The current studies demonstrate that enhanced action potential firing produced by NGF was blocked by inhibitors of translation, but not transcription. In vitro studies showed that NGF elevated the protein levels of PKMzeta, which was also prevented by inhibitors of translation. Intraplantar injection of NGF produced a rapid and maintained increase in mechanical sensitivity whose onset was delayed by translation inhibit..., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1905609 positive regulation of smooth muscle cell-matrix adhesion;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P09217-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11384-1", "uniprot_id": [ { "id": "SECR_RAT", "url": "https://www.uniprot.org/uniprot/P11384", "type": "external" } ], "mass": 15072.0, "length": 134, "protein_name": "Secretin", "gene_name": "Sct", "organism": "Rat", "refseq_name": "secretin precursor", "refseq_ac": [ { "id": "NP_073161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073161", "type": "external" } ], "gene_names_uniprotkb": "Sct", "gene_names_refseq": "Sct; Secr", "protein_names_uniprotkb": "Secretin", "protein_names_refseq": "secretin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:24769); (R-RNO-420092)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "12403838;15276242;1711228;19805236;2061329;22194894;22673903;22764231;2315322;25403455;2719704;3047699;7958688;8568688;9506976;9655680", "class_list": "", "function": "Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:19805236, PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:12403838, PubMed:9506976). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (By similarity). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (PubMed:19805236). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Propose that eyeblink conditioning (EBC)-induced secretin release from Purkinje cells modulates EBC acquisition by reducing surface expression of Kv1.2 at one or both of these sites Publication Status: Online-Only, [RefSeq, PubMed]; Secretin decreases cell surface Kv1.2 alpha-subunit levels by modulating Kv1.2 alpha- subunit endocytic trafficking., [RefSeq, PubMed]; Ursodeoxycholic acid is conjugated in order to promote secretin-stimulated hydrocholeresis in rats through Ae2, microtubules, intracellular Ca(2+), PKCalpha, PI3K, PKA, and MEK., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0046659 digestive hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:1903640 negative regulation of gastrin-induced gastric acid secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008542 visual learning;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P11384-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17988-1", "uniprot_id": [ { "id": "ST1A1_RAT", "url": "https://www.uniprot.org/uniprot/P17988", "type": "external" } ], "mass": 33906.0, "length": 291, "protein_name": "Sulfotransferase 1A1", "gene_name": "Sult1a1", "organism": "Rat", "refseq_name": "sulfotransferase 1A1", "refseq_ac": [ { "id": "NP_114022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114022", "type": "external" } ], "gene_names_uniprotkb": "Sult1a1; St1a1", "gene_names_refseq": "ASTIV; Mx-ST; PST-1; St1a1; Stm; Stp1; Sult1a1; Sult1a3", "protein_names_uniprotkb": "Sulfotransferase 1A1; 2.8.2.1; ASTIV; Aryl sulfotransferase IV; Aryl sulfotransferase; Minoxidil sulfotransferase; Mx-ST; PST-1; Phenol sulfotransferase; ST1A1; Sulfokinase; Tyrosine-ester sulfotransferase", "protein_names_refseq": "Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member 3; Phenol sulfotransferase 1a1; aryl sulfotransferase IV; minoxidil sulfotransferase; sulfokinase; sulfotransferase 1A1; sulfotransferase family 1A, phenol-preferring, member 1; sulfotransferase family, cytosolic, 1A, phenol preferring; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; sulphotransferase family cytosolic 1A phenol-prefering member 1; tyrosine-ester sulfotransferase", "tax_id": 10116, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); benign neoplasm (Disease Ontology:DOID:0060072); hereditary lymphedema IA (Disease Ontology:DOID:0070210); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); lymphangioma (Disease Ontology:DOID:1475); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (rno:83783); (R-RNO-156584); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "1511441;1513323;22673903;23026138;2374726;25370010;26022216;31100325;7889867;7982943;8033271;8299966;8447833", "class_list": "", "function": "High SULT1A1 expression is associated with high altitude pulmonary edema., [RefSeq, PubMed]; Higher SULT1A1 levels were observed in rats as well as in humans exposed to high altitude, when compared to sea-level controls Erratum:[Sci Rep. 2022 Feb 1;12(1):1981. doi: 10.1038/s41598-022-06169-9. PMID: 35105916] Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that the physiological functions of SULT1A1 in different brain regions can be affected by methamphetamine., [RefSeq, PubMed]; SULT1A1 is responsible for bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds (PubMed:1513323, PubMed:7889867, PubMed:8447833). Plays an important roles in the sulfonation of endogenous molecules such as steroid hormones (By similarity). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (PubMed:1513323). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. Catalyzes the sulfate conjugation of dopamine. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548D2", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0047894 flavonol 3-sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0004062 aryl sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation;GO:0008217 regulation of blood pressure;GO:0006068 ethanol catabolic process;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P17988-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30680-1", "uniprot_id": [ { "id": "SSR2_RAT", "url": "https://www.uniprot.org/uniprot/P30680", "type": "external" } ], "mass": 41200.0, "length": 369, "protein_name": "Somatostatin receptor type 2", "gene_name": "Sstr2", "organism": "Rat", "refseq_name": "somatostatin receptor type 2", "refseq_ac": [ { "id": "NP_062221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062221", "type": "external" } ], "gene_names_uniprotkb": "Sstr2", "gene_names_refseq": "Smstr2; Sstr2", "protein_names_uniprotkb": "Somatostatin receptor type 2; SRIF-1; SS-2-R; SS2-R; SS2R", "protein_names_refseq": "SRIF-1; SS-2-R; SS2-R; SS2R; somatostatin receptor subtype 2; somatostatin receptor type 2; somatotropin release-inhibiting factor receptor", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); corneal neovascularization (Disease Ontology:DOID:11382); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Kawasaki disease (Disease Ontology:DOID:13378); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); Leydig cell tumor (Disease Ontology:DOID:2696); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); thyroid gland carcinoma (Disease Ontology:DOID:3963); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:54305); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11134004;1348934;1374909;17981995;19389921;19434240;30544226;30609928;32315148;33045023;34487822;8386508", "class_list": "", "function": "Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly., [RefSeq, PubMed]; Elevated miR-16-5p induces somatostatin receptor 2 expression in neuroendocrine tumor cells. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Role of Basolateral Amygdalar Somatostatin 2 Receptors in a Rat Model of Chronic Anxiety., [RefSeq, PubMed]; Study suggests that SSTR2 might play a critical role in the aetiopathogenesis of periodontitis Publication Status: Online-Only, [RefSeq, PubMed]; Suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion during lactation, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0030432 peristalsis;GO:0060125 negative regulation of growth hormone secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P30680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63319-1", "uniprot_id": [ { "id": "KPCG_RAT", "url": "https://www.uniprot.org/uniprot/P63319", "type": "external" } ], "mass": 78358.0, "length": 697, "protein_name": "Protein kinase C gamma type", "gene_name": "Prkcg", "organism": "Rat", "refseq_name": "protein kinase C gamma type", "refseq_ac": [ { "id": "NP_036760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036760", "type": "external" } ], "gene_names_uniprotkb": "Prkcg; Pkcc; Pkcg; Prkcc", "gene_names_refseq": "PKCI; PKC; Prkcc; Prkcg; Prkc; RATPKCI", "protein_names_uniprotkb": "Protein kinase C gamma type; 2.7.11.13; PKC-gamma", "protein_names_refseq": "PKC-gamma; protein kinase C gamma type; protein kinase C type I (gamma type)", "tax_id": 10116, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); alcohol use disorder (Disease Ontology:DOID:1574); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:24681); (R-RNO-111933); (R-RNO-114516); (R-RNO-416993); (R-RNO-5099900); (R-RNO-76005)", "pathway_count": 6, "publication_count": 18, "publication_id_list": "10336135;12471040;14688616;15705736;15936117;17612968;18295358;2246272;22673903;30355630;31283971;32865105;3387228;34416391;37544581;3755379;9271501;9287082", "class_list": "", "function": "A 5-HT2A receptor to protein kinase C gamma pathway leads to the behavioral allodynia and morphological changes in protein kinase C gamma interneurons., [RefSeq, PubMed]; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn., [RefSeq, PubMed]; Pain modulation effect on motor cortex after optogenetic stimulation in shPKCgamma knockdown dorsal root ganglion-compressed Sprague-Dawley rat model., [RefSeq, PubMed]; Prenatal stress possibly decreases hippocampal PKCgamma activity, resulting in a reduction of p-GAP-43 and p-Ng, which underlies insufficient CaMKII activation, thereby impairing spatial learning and memory., [RefSeq, PubMed]; Sex-specific effects of 17beta-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERalpha and ERbeta and require palmitoylation to translocate the receptors to the plasma membrane., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 10, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 10, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 10, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "P05697;Q5FWS3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0032425 positive regulation of mismatch repair;GO:0060384 innervation;GO:0032095 regulation of response to food;GO:0007611 learning or memory;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P63319-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PS20-1", "uniprot_id": [ { "id": "JPH2_RAT", "url": "https://www.uniprot.org/uniprot/Q2PS20", "type": "external" } ], "mass": 74259.0, "length": 692, "protein_name": "Junctophilin-2", "gene_name": "Jph2", "organism": "Rat", "refseq_name": "junctophilin-2", "refseq_ac": [ { "id": "NP_001033063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033063", "type": "external" } ], "gene_names_uniprotkb": "Jph2; Jp2", "gene_names_refseq": "Jph2", "protein_names_uniprotkb": "Junctophilin-2; JP-2; Junctophilin type 2", "protein_names_refseq": "JP-2; junctophilin type 2; junctophilin-2", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); dilated cardiomyopathy 2E (Disease Ontology:DOID:0081161); hypertrophic cardiomyopathy 17 (Disease Ontology:DOID:0110323); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:296345)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22404946;22673903;31506724;31904168;32053184", "class_list": "", "function": "Degradation of junctophilin-2 by MMP-2 is an early consequence of myocardial IR injury which may initiate a cascade of sequelae leading to impaired contractile function. Publication Status: Online-Only, [RefSeq, PubMed]; JPH2 is dispersed throughout RyR clusters and that the packing of JPH2 into junctions and the assembly of RyR clusters are tightly linked, [RefSeq, PubMed]; Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes., [RefSeq, PubMed]; Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions., [UniProtKB, UniProtKB]; The MORN domain of Junctophilin2 regulates functional interactions with small-conductance Ca(2+) -activated potassium channel subtype2 (SK2)., [RefSeq, PubMed]; Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0003677 DNA binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030018 Z disc", "go_biological_process": "GO:0055024 regulation of cardiac muscle tissue development;GO:0006351 DNA-templated transcription;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0055074 calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2PS20-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MHT4-1", "uniprot_id": [ { "id": "STPAP_RAT", "url": "https://www.uniprot.org/uniprot/Q3MHT4", "type": "external" } ], "mass": 94378.0, "length": 866, "protein_name": "Speckle targeted PIP5K1A-regulated poly(A) polymerase", "gene_name": "Eef1g; Tut1", "organism": "Rat", "refseq_name": "speckle targeted PIP5K1A-regulated poly(A) polymerase", "refseq_ac": [ { "id": "NP_001029073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029073", "type": "external" } ], "gene_names_uniprotkb": "Eef1g; Tut1; Eef1g; Rbm21", "gene_names_refseq": "Tut1", "protein_names_uniprotkb": "Speckle targeted PIP5K1A-regulated poly(A) polymerase; 2.7.7.19; 2.7.7.52; RNA-binding motif protein 21; RNA-binding protein 21; Star-PAP; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase", "protein_names_refseq": "RNA-binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; speckle targeted PIP5K1A-regulated poly(A) polymerase; star-PAP", "tax_id": 10116, "disease": "", "pathway": " (rno:499314); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;31598705", "class_list": "", "function": "Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation., [UniProtKB, UniProtKB]; Probably plays a role in anchoring the complex to other cellular components., [UniProtKB, UniProtKB, UniProtKB]; The loss of NQO1 during hypertrophy was rescued by ectopic expression of the distal- but not the proximal- or middle-specific NQO1 mRNA isoforms in the presence of Star-PAP expression, and reverses molecular events of hypertrophy in cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0034477 U6 snRNA 3'-end processing;GO:0016180 snRNA processing;GO:0031124 mRNA 3'-end processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3MHT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MIE4-1", "uniprot_id": [ { "id": "VAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q3MIE4", "type": "external" } ], "mass": 43119.0, "length": 404, "protein_name": "NADPH-dependent quinone oxidoreductase VAT1", "gene_name": "Vat1", "organism": "Rat", "refseq_name": "NADPH-dependent quinone oxidoreductase VAT1", "refseq_ac": [ { "id": "NP_001028855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028855", "type": "external" } ], "gene_names_uniprotkb": "Vat1", "gene_names_refseq": "MIB; VAT-1; Vat1", "protein_names_uniprotkb": "NADPH-dependent quinone oxidoreductase VAT1; 1.6.5.5; MIB; Mitofusin-binding protein; Synaptic vesicle membrane protein VAT-1 homolog; VAT-1; Vesicle amine transport 1", "protein_names_refseq": "NADPH-dependent quinone oxidoreductase VAT1; mitofusin-binding protein; synaptic vesicle membrane protein VAT-1 homolog; vesicle amine transport protein 1 homolog (T californica)", "tax_id": 10116, "disease": "", "pathway": " (rno:287721); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17105775;21394740;22673903;34008672", "class_list": "", "function": "Cloning of Mitofusin-binding protein., [RefSeq, PubMed]; Multifunctional protein with enzymatic and transport activities. Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear. Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes (By similarity). Could regulate mitochondrial fusion through its interaction with mitofusins (PubMed:17105775)., [UniProtKB, UniProtKB, PubMed]; Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues., [RefSeq, PubMed]; We demonstrate that VAT-1 is a novel pathogenic factor in benign prostatic hyperplasia associated with cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003960 quinone reductase (NADPH) activity;GO:0008753 NADPH dehydrogenase (quinone) activity;GO:0120014 phospholipid transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0010637 negative regulation of mitochondrial fusion;GO:0120010 intermembrane phospholipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q3MIE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2M8-1", "uniprot_id": [ { "id": "MDC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2M8", "type": "external" } ], "mass": 136948.0, "length": 1279, "protein_name": "Mediator of DNA damage checkpoint protein 1", "gene_name": "Mdc1", "organism": "Rat", "refseq_name": "mediator of DNA damage checkpoint protein 1", "refseq_ac": [ { "id": "NP_001159747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159747", "type": "external" } ], "gene_names_uniprotkb": "Mdc1", "gene_names_refseq": "Mdc1", "protein_names_uniprotkb": "Mediator of DNA damage checkpoint protein 1", "protein_names_refseq": "mediator of DNA damage checkpoint protein 1", "tax_id": 10116, "disease": "breast carcinoma (Disease Ontology:DOID:3459); lung carcinoma (Disease Ontology:DOID:3905); cervical cancer (Disease Ontology:DOID:4362); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:309595)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;22673903", "class_list": "", "function": "Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis. Required for the repair of DSBs via homologous recombination by promoting recruitment of NBN component of the MRN complex to DSBs., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 42, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6MG15", "ec_number_list": [], "go_molecular_function": "GO:0140463 chromatin-protein adaptor activity;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0035861 site of double-strand break;GO:0005694 chromosome", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2M8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63210-1", "uniprot_id": [ { "id": "GNA12_RAT", "url": "https://www.uniprot.org/uniprot/Q63210", "type": "external" } ], "mass": 44065.0, "length": 379, "protein_name": "Guanine nucleotide-binding protein subunit alpha-12", "gene_name": "Gna12", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit alpha-12", "refseq_ac": [ { "id": "NP_112296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112296", "type": "external" } ], "gene_names_uniprotkb": "Gna12", "gene_names_refseq": "Gna12; Hg1m1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha-12; G alpha-12; G protein subunit alpha-12", "protein_names_refseq": "g alpha-12; guanine nucleotide binding protein (G protein) alpha 12; guanine nucleotide binding protein, alpha 12; guanine nucleotide-binding protein subunit alpha-12; heterotrimeric guanine nucleotide-binding protein 1m1", "tax_id": 10116, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:81663); (R-RNO-416482)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12176367;12623966;21212405;21633357;25989500", "class_list": "", "function": "Dopamine receptor D5 is linked to Galpha12 in the nephron., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367, PubMed:21212405). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:12176367)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; It was concluded that a D3 receptor interaction with Galpha12/Galpha13 that increases sodium excretion may have a role in the regulation of blood pressure., [RefSeq, PubMed]; Suggest that activation of D3R, by decreasing Galpha12-induced renal damage, may exert a protective effect from renal I/R injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63210-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63572-1", "uniprot_id": [ { "id": "TESK1_RAT", "url": "https://www.uniprot.org/uniprot/Q63572", "type": "external" } ], "mass": 67988.0, "length": 628, "protein_name": "Dual specificity testis-specific protein kinase 1", "gene_name": "Tesk1", "organism": "Rat", "refseq_name": "dual specificity testis-specific protein kinase 1", "refseq_ac": [ { "id": "NP_113766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113766", "type": "external" } ], "gene_names_uniprotkb": "Tesk1", "gene_names_refseq": "Tesk1", "protein_names_uniprotkb": "Dual specificity testis-specific protein kinase 1; 2.7.12.1; Testicular protein kinase 1", "protein_names_refseq": "dual specificity testis-specific protein kinase 1; testicular protein kinase 1; testis specific protein kinase 1; testis-specific kinase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29460); (R-RNO-446388)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10207045;11555644;15817463;17974561;18216281;22302232;8537404", "class_list": "", "function": "By selectively modulating the downstream effects of Spry2, Tesk1 may thus serve as a molecular determinant of the signaling outcome., [RefSeq, PubMed]; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (PubMed:10207045). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (PubMed:11555644, PubMed:18216281). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (By similarity). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (PubMed:8537404)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; TESK1 plays important roles in promyelinating Schwann cells, potentially through subcellular localization change and participation in integrin-mediated actin reorganization., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007283 spermatogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0030036 actin cytoskeleton organization;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63572-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642F4-1", "uniprot_id": [ { "id": "SC22A_RAT", "url": "https://www.uniprot.org/uniprot/Q642F4", "type": "external" } ], "mass": 34902.0, "length": 307, "protein_name": "Vesicle-trafficking protein SEC22a", "gene_name": "Sec22a", "organism": "Rat", "refseq_name": "vesicle-trafficking protein SEC22a", "refseq_ac": [ { "id": "NP_476488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476488", "type": "external" } ], "gene_names_uniprotkb": "Sec22a; Sec22l2", "gene_names_refseq": "Sec22a; Sec22l2", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22a; SEC22 vesicle-trafficking protein homolog A; SEC22 vesicle-trafficking protein-like 2; rSec22a", "protein_names_refseq": "SEC22 vesicle trafficking protein homolog A; SEC22 vesicle-trafficking protein-like 2; rSec22a; vesicle-trafficking protein SEC22a", "tax_id": 10116, "disease": "", "pathway": " (rno:117513); (R-RNO-204005)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8621431", "class_list": "", "function": "May be involved in vesicle transport between the ER and the Golgi complex., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62891", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q642F4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64319-1", "uniprot_id": [ { "id": "SLC31_RAT", "url": "https://www.uniprot.org/uniprot/Q64319", "type": "external" } ], "mass": 78507.0, "length": 683, "protein_name": "Amino acid transporter heavy chain SLC3A1", "gene_name": "Slc3a1", "organism": "Rat", "refseq_name": "amino acid transporter heavy chain SLC3A1", "refseq_ac": [ { "id": "NP_058912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058912", "type": "external" } ], "gene_names_uniprotkb": "Slc3a1; Nbat", "gene_names_refseq": "NBAT; Slc3a1; rBAT", "protein_names_uniprotkb": "Amino acid transporter heavy chain SLC3A1; D2; NAA-TR; NBAT; Neutral and basic amino acid transport protein; Solute carrier family 3 member 1; b(0,+)-type amino acid transporter-related heavy chain; rBAT", "protein_names_refseq": "D2; NAA-TR; amino acid transporter heavy chain SLC3A1; b(0,+)-type amino acid transport protein; b(0,+)-type amino acid transporter-related heavy chain; neutral and basic amino acid transport protein rBAT; neutral and basic amino acid transporter protein; solute carrier family 3 (amino acid transporter heavy chain), member 1", "tax_id": 10116, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (rno:29484); (R-RNO-352230)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10506124;1376924;1729674;22673903;8052618", "class_list": "glycogene;glycosylhydrolase", "function": "Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane (By similarity) (PubMed:1376924, PubMed:1729674). Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules (By similarity) (PubMed:1376924, PubMed:1729674). Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q62672", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005774 vacuolar membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006865 amino acid transport;GO:0015811 L-cystine transport;GO:0010467 gene expression;GO:0015810 aspartate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64319-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64595-1", "uniprot_id": [ { "id": "KGP2_RAT", "url": "https://www.uniprot.org/uniprot/Q64595", "type": "external" } ], "mass": 87182.0, "length": 762, "protein_name": "cGMP-dependent protein kinase 2", "gene_name": "Prkg2", "organism": "Rat", "refseq_name": "cGMP-dependent protein kinase 2", "refseq_ac": [ { "id": "NP_037144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037144", "type": "external" } ], "gene_names_uniprotkb": "Prkg2", "gene_names_refseq": "GDPKII; Prkg2; cGKII", "protein_names_uniprotkb": "cGMP-dependent protein kinase 2; 2.7.11.12; cGK 2; cGK2; cGKII; cGMP-dependent protein kinase II", "protein_names_refseq": "CGK 2; cGK2; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP-dependent, type II; type II cGMP-dependent protein kinase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); withdrawal disorder (Disease Ontology:DOID:0060001); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); bone disease (Disease Ontology:DOID:0080001); acromesomelic dysplasia 4 (Disease Ontology:DOID:0081238); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); asbestosis (Disease Ontology:DOID:10320); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); aplastic anemia (Disease Ontology:DOID:12449); malignant renovascular hypertension (Disease Ontology:DOID:13730); Parkinson's disease (Disease Ontology:DOID:14330); respiratory system disease (Disease Ontology:DOID:1579); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25523); (R-RNO-1474151); (R-RNO-418457); (R-RNO-9648002)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "15872007;18031684;22673903;23545413;24966379;25070890;28057484;7937783;9465038", "class_list": "", "function": "Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane (PubMed:9465038). Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (Probable). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (PubMed:18031684). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; We conclude that cGKII controls the homeostatic balance of vesicle exocytosis and endocytosis in synaptic boutons of rat cerebellar granule cells., [RefSeq, PubMed]; Which in turn activates cGKII and induces the phosphorylation of GluA1., [RefSeq, PubMed]; Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a low affinity for cGMP, did not., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "1.1.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.153", "type": "external" }, { "id": "4.2.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.3.12", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004692 cGMP-dependent protein kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0051019 mitogen-activated protein kinase binding;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64595-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64617-1", "uniprot_id": [ { "id": "KPCL_RAT", "url": "https://www.uniprot.org/uniprot/Q64617", "type": "external" } ], "mass": 77947.0, "length": 683, "protein_name": "Protein kinase C eta type", "gene_name": "Prkch", "organism": "Rat", "refseq_name": "protein kinase C eta type", "refseq_ac": [ { "id": "NP_112347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112347", "type": "external" } ], "gene_names_uniprotkb": "Prkch; Pkch", "gene_names_refseq": "Prkch", "protein_names_uniprotkb": "Protein kinase C eta type; 2.7.11.13; PKC-L; nPKC-eta", "protein_names_refseq": "PKC-L; nPKC-eta; protein kinase C eta type", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:81749); (R-RNO-114508)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1426252;22673903;29482336;38115999", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization (By similarity)., [UniProtKB]; LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCeta Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Study provides mechanistic evidence that inhibition of PKCeta isoform alleviated mitochondrial injuries and function, attenuated apoptosis, and renal fibrosis in high glucose (HG)-cultured advanced oxidation protein products (AOPPs)-induced HK-2 cells. Thus, AOPPs-induced mitochondrial dysfunction and oxidative stress cause tubulointerstitial fibrosis in diabetic nephropathy via activation of the PKCeta isoform., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0006468 protein phosphorylation;GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0010744 positive regulation of macrophage derived foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64617-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY30-1", "uniprot_id": [ { "id": "SCPDL_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY30", "type": "external" } ], "mass": 47088.0, "length": 429, "protein_name": "Saccharopine dehydrogenase-like oxidoreductase", "gene_name": "Sccpdh", "organism": "Rat", "refseq_name": "saccharopine dehydrogenase-like oxidoreductase", "refseq_ac": [ { "id": "NP_001014007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014007", "type": "external" } ], "gene_names_uniprotkb": "Sccpdh", "gene_names_refseq": "RGD1311440; Sccpdh", "protein_names_uniprotkb": "Saccharopine dehydrogenase-like oxidoreductase; 1.-.-.-", "protein_names_refseq": "probable saccharopine dehydrogenase; saccharopine dehydrogenase-like oxidoreductase", "tax_id": 10116, "disease": "", "pathway": " (rno:305021); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane;GO:0030496 midbody", "go_biological_process": "GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AY30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6I7R3-1", "uniprot_id": [ { "id": "ISOC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6I7R3", "type": "external" } ], "mass": 32002.0, "length": 297, "protein_name": "Isochorismatase domain-containing protein 1", "gene_name": "Isoc1", "organism": "Rat", "refseq_name": "isochorismatase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001014264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014264", "type": "external" } ], "gene_names_uniprotkb": "Isoc1", "gene_names_refseq": "DR-NR#1; Isoc1; RGD1307632", "protein_names_uniprotkb": "Isochorismatase domain-containing protein 1; DR-NR1; Down-regulated in nephrectomized rat kidney protein 1", "protein_names_refseq": "DR-NR1; Down-regulated in nephrectomized rat kidney #1; down-regulated in nephrectomized rat kidney protein 1; isochorismatase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:364879)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15200410;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6I7R3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811S9-1", "uniprot_id": [ { "id": "GNL3_RAT", "url": "https://www.uniprot.org/uniprot/Q811S9", "type": "external" } ], "mass": 60661.0, "length": 538, "protein_name": "Guanine nucleotide-binding protein-like 3", "gene_name": "Gnl3", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein-like 3", "refseq_ac": [ { "id": "NP_783170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783170", "type": "external" } ], "gene_names_uniprotkb": "Gnl3; Ns", "gene_names_refseq": "Gnl3; Ns", "protein_names_uniprotkb": "Guanine nucleotide-binding protein-like 3; Nucleolar GTP-binding protein 3; Nucleostemin", "protein_names_refseq": "guanine nucleotide binding protein-like 3 (nucleolar); guanine nucleotide-binding protein-like 3; nucleolar GTP-binding protein 3; nucleostemin", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:290556); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12464630;15657390;15857956;16139428;22673903;26138242;34785448", "class_list": "", "function": "Analysis of nucleolar localization of stem cell protein nucleostemin, [RefSeq, PubMed]; In summary, this report suggested that Nucleostemin may exert the anti-apoptotic effect through Nucleostemin-p53 signaling pathway after myocardial reperfusion injury., [RefSeq, PubMed]; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)., [UniProtKB, PubMed]; Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma., [RefSeq, PubMed]; Results suggest that nucleostemin, but not Oct-4 or Nanog, is expressed in bone marrow stromal cells where it possibly regulates self-renewal cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q566E0", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0005694 chromosome", "go_biological_process": "GO:1904816 positive regulation of protein localization to chromosome, telomeric region;GO:0042127 regulation of cell population proliferation;GO:0019827 stem cell population maintenance;GO:0033235 positive regulation of protein sumoylation;GO:0017145 stem cell division", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q811S9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R455-1", "uniprot_id": [ { "id": "TRPM8_RAT", "url": "https://www.uniprot.org/uniprot/Q8R455", "type": "external" } ], "mass": 127629.0, "length": 1104, "protein_name": "Transient receptor potential cation channel subfamily M member 8", "gene_name": "Trpm8", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily M member 8", "refseq_ac": [ { "id": "NP_599198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599198", "type": "external" } ], "gene_names_uniprotkb": "Trpm8; Cmr1", "gene_names_refseq": "CMR1; Trpm8", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily M member 8; Cold menthol receptor 1", "protein_names_refseq": "cold menthol receptor 1; transient receptor potential cation channel subfamily M member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:171384); (R-RNO-3295583)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11882888;12634279;19176480;20214891;32929340;33037615;35489198;37542841;38574849", "class_list": "", "function": "Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels regulate microglial activity., [RefSeq, PubMed]; CMR1 is a member of the TRP family of excitatory ion channels and is proposed to function as a transducer of cold stimuli in the somatosensory system, [RefSeq, PubMed]; Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes., [RefSeq, PubMed]; Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes., [RefSeq, PubMed]; Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+) (PubMed:11882888). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures (By similarity). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (By similarity). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TRIM4 interacts with TRPM8 and regulates its channel function through K423-mediated ubiquitination., [RefSeq, PubMed]; TRPM8 is preferentially expressed within a subset of rapidly responsive, low-threshold (approximately 30 degrees C), cold-sensitive neurons in trigeminal ganglia., [RefSeq, PubMed]; TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0099604 ligand-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0009409 response to cold;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0009266 response to temperature stimulus;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q8R455-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13255-1", "uniprot_id": [ { "id": "GNMT_RAT", "url": "https://www.uniprot.org/uniprot/P13255", "type": "external" } ], "mass": 32549.0, "length": 293, "protein_name": "Glycine N-methyltransferase", "gene_name": "Gnmt", "organism": "Rat", "refseq_name": "glycine N-methyltransferase", "refseq_ac": [ { "id": "NP_058780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058780", "type": "external" } ], "gene_names_uniprotkb": "Gnmt; Fbp-cII", "gene_names_refseq": "Gnmt", "protein_names_uniprotkb": "Glycine N-methyltransferase; 2.1.1.20; Folate-binding protein", "protein_names_refseq": "folate-binding protein; glycine N-methyltransferase; glycine methyltransferase", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); aromatic L-amino acid decarboxylase deficiency (Disease Ontology:DOID:0090123); glycine N-methyltransferase deficiency (Disease Ontology:DOID:0111037); portal hypertension (Disease Ontology:DOID:10762); nephrotic syndrome (Disease Ontology:DOID:1184); Parkinson's disease (Disease Ontology:DOID:14330); hyperinsulinism (Disease Ontology:DOID:2018); bipolar disorder (Disease Ontology:DOID:3312); inherited metabolic disorder (Disease Ontology:DOID:655); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:25134); (R-RNO-389661)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10756111;12859184;17158459;22037183;25336395;2822402;3838667;6587377;8810903;9655336", "class_list": "", "function": "Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine., [UniProtKB, UniProtKB]; Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20", "type": "external" }, { "id": "2.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.8", "type": "external" } ], "go_molecular_function": "GO:0017174 glycine N-methyltransferase activity;GO:0042802 identical protein binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0005542 folic acid binding;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0034708 methyltransferase complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0005977 glycogen metabolic process;GO:0006730 one-carbon metabolic process;GO:0032259 methylation;GO:0046498 S-adenosylhomocysteine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13255-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJS0-1", "uniprot_id": [ { "id": "DHX30_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJS0", "type": "external" } ], "mass": 133997.0, "length": 1194, "protein_name": "ATP-dependent RNA helicase DHX30", "gene_name": "Dhx30", "organism": "Rat", "refseq_name": "ATP-dependent RNA helicase DHX30", "refseq_ac": [ { "id": "NP_001013267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013267", "type": "external" } ], "gene_names_uniprotkb": "Dhx30", "gene_names_refseq": "Dhx30", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX30; 3.6.4.13; DEAH box protein 30", "protein_names_refseq": "ATP-dependent RNA helicase DHX30; DEAH (Asp-Glu-Ala-His) box helicase 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; DEAH-box helicase 30; putative ATP-dependent RNA helicase DHX30", "tax_id": 10116, "disease": "", "pathway": " (rno:367172)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21204022;22673903", "class_list": "", "function": "RNA-dependent helicase (By similarity). Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Associates with mitochondrial DNA (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (PubMed:21204022). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0007417 central nervous system development;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BJS0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19490-1", "uniprot_id": [ { "id": "GRIA1_RAT", "url": "https://www.uniprot.org/uniprot/P19490", "type": "external" } ], "mass": 101579.0, "length": 907, "protein_name": "Glutamate receptor 1", "gene_name": "Gria1", "organism": "Rat", "refseq_name": "glutamate receptor 1 precursor", "refseq_ac": [ { "id": "NP_113796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113796", "type": "external" } ], "gene_names_uniprotkb": "Gria1; GluA1; Glur1", "gene_names_refseq": "GluA1; Gria1; gluR-A", "protein_names_uniprotkb": "Glutamate receptor 1; AMPA-selective glutamate receptor 1; GluR-1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1", "protein_names_refseq": "AMPA-selective glutamate receptor 1; gluR-1; gluR-K1; glutamate receptor 1 precursor; glutamate receptor 1; glutamate receptor A; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1)", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); autosomal dominant intellectual developmental disorder 67 (Disease Ontology:DOID:0061040); autosomal recessive intellectual developmental disorder 76 (Disease Ontology:DOID:0081235); traumatic brain injury (Disease Ontology:DOID:0081292); neurodegenerative disease (Disease Ontology:DOID:1289); hepatic encephalopathy (Disease Ontology:DOID:13413); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); morphine dependence (Disease Ontology:DOID:2560); central nervous system disease (Disease Ontology:DOID:331); schizoaffective disorder (Disease Ontology:DOID:5418); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); hyperhomocysteinemia (Disease Ontology:DOID:9279); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:50592); (R-RNO-204005); (R-RNO-399710); (R-RNO-399719); (R-RNO-416993); (R-RNO-438066); (R-RNO-5694530); (R-RNO-8849932)", "pathway_count": 8, "publication_count": 28, "publication_id_list": "10537080;11773314;12070168;15456832;16630835;16793768;1699275;17069616;1709304;18031684;18817736;19234459;19265014;20805473;21639859;2166337;2168579;2480522;25656447;35820448;37544581;37955815;37993087;38843836;7877986;8848293;9405465;9677374", "class_list": "", "function": "Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:2166337, PubMed:2168579). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:11773314, PubMed:18817736). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (PubMed:16793768, PubMed:19265014). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:16793768, PubMed:19265014). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (By similarity). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable (PubMed:1709304). Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (PubMed:11773314)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; NETO2-GluK2 interaction contributes to postoperative pain hypersensitivity through inducing PKCgamma activation and synaptic incorporation of AMPA receptor GluR1 subunits in rat dorsal horn., [RefSeq, PubMed]; Phosphorylation of 4.1N by CaMKII Regulates the Trafficking of GluA1-containing AMPA Receptors During Long-term Potentiation in Acute Rat Hippocampal Brain Slices., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Upregulation of Hevin contributes to postoperative pain hypersensitivity by inducing neurexin1beta/neuroligin1-mediated synaptic targeting of GluA1-containing AMPA receptors in rat dorsal horn., [RefSeq, PubMed]; Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 11, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 18, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0031698 beta-2 adrenergic receptor binding;GO:0031681 G-protein beta-subunit binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0071242 cellular response to ammonium ion;GO:0071359 cellular response to dsRNA;GO:0090326 positive regulation of locomotion involved in locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "P19490-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31016-1", "uniprot_id": [ { "id": "DLG4_RAT", "url": "https://www.uniprot.org/uniprot/P31016", "type": "external" } ], "mass": 80465.0, "length": 724, "protein_name": "Disks large homolog 4", "gene_name": "Dlg4", "organism": "Rat", "refseq_name": "disks large homolog 4", "refseq_ac": [ { "id": "NP_062567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062567", "type": "external" } ], "gene_names_uniprotkb": "Dlg4; Dlgh4; Psd95", "gene_names_refseq": "Dlg4; Dlgh4; PSD95; Sap90", "protein_names_uniprotkb": "Disks large homolog 4; PSD-95; Postsynaptic density protein 95; SAP-90; SAP90; Synapse-associated protein 90", "protein_names_refseq": "PSD-95; SAP-90; discs, large homolog 4; disks large homolog 4; postsynaptic density protein 95; synapse-associated protein 90; synapse-associated protein SAP90", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); autosomal dominant intellectual developmental disorder 62 (Disease Ontology:DOID:0061035); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); Williams-Beuren syndrome (Disease Ontology:DOID:1928); carcinoma (Disease Ontology:DOID:305); temporal lobe epilepsy (Disease Ontology:DOID:3328); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:29495); (R-RNO-399719); (R-RNO-438066); (R-RNO-451308); (R-RNO-5625900); (R-RNO-5673001); (R-RNO-5682910); (R-RNO-6794361); (R-RNO-8849932)", "pathway_count": 9, "publication_count": 59, "publication_id_list": "10623522;10629226;11134026;11483650;11502259;11779504;11779506;11923279;11997254;12151521;1419001;14642282;15123241;15304526;15317815;15358863;15603741;15629447;16054660;16495444;16630835;16990550;17334360;18721130;19072119;19118189;19596852;20089912;20220006;20628354;20962234;21119615;22673903;23300088;23864697;25393018;26679993;27307232;27330081;27458189;27756895;30021165;30937346;31189538;33990590;35243702;35257794;35609859;35725243;37525090;7569905;7680343;8674113;8922396;9115257;9581761;9581762;9756850;9786987", "class_list": "", "function": "Glycoproteins of Capsosiphon fulvescens modulate synaptic clustering of PSD95 and prevent social isolation-induced cognitive decline in aged male rats., [RefSeq, PubMed]; Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats. Erratum:[Eur J Neurosci. 2022 Apr;55(8):2047. doi: 10.1111/ejn.15667. PMID: 35466467], [RefSeq, PubMed]; Inhibition of the NR2B-PSD95 Interaction Exerts Neuroprotective Effects on Retinal Ischemia-Reperfusion Injury., [RefSeq, PubMed]; Inhibition of the postsynaptic density protein 95 on the protective effect of Ang-(1-7)-Mas on cerebral ischaemia injury., [RefSeq, PubMed]; Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15317815, PubMed:15358863, PubMed:19596852, PubMed:20628354, PubMed:23300088, PubMed:26679993). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:19596852). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Transcriptome analysis reveals the neuroprotective effect of Dlg4 against fastigial nucleus stimulation-induced ischemia/reperfusion injury in rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97631", "ec_number_list": [], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019901 protein kinase binding;GO:0033130 acetylcholine receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007399 nervous system development;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 6.0, "record_id": "P31016-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61765-1", "uniprot_id": [ { "id": "STXB1_RAT", "url": "https://www.uniprot.org/uniprot/P61765", "type": "external" } ], "mass": 67569.0, "length": 594, "protein_name": "Syntaxin-binding protein 1", "gene_name": "Stxbp1", "organism": "Rat", "refseq_name": "syntaxin-binding protein 1", "refseq_ac": [ { "id": "NP_037170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037170", "type": "external" } ], "gene_names_uniprotkb": "Stxbp1; Unc18a", "gene_names_refseq": "ANC18HA; Munc18-1; NSEC1A; Sec1; Stxbp1; Unc18-1; n-sec1; nSec1; rbSec1A; rbSec1B; rbSec1", "protein_names_uniprotkb": "Syntaxin-binding protein 1; N-Sec1; Protein unc-18 homolog 1; Protein unc-18 homolog A; Unc-18A; Unc18-1; p67; rbSec1", "protein_names_refseq": "p67; protein unc-18 homolog 1; protein unc-18 homolog A; syntaxin-binding protein 1; unc-18 homolog; unc-18-1; unc-18A", "tax_id": 10116, "disease": "West syndrome (Disease Ontology:DOID:0050562); early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 4 (Disease Ontology:DOID:0080436); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (rno:25558); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-888590)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10746715;12058058;21689256;22673903;29946239;33159991;33468652;33590815;36335177;38755165;38843836;7536802;7698978;8108429;8134339;8247129", "class_list": "", "function": "CASK, APBA1, and STXBP1 collaborate during insulin secretion., [RefSeq, PubMed]; Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site. Publication Status: Online-Only, [RefSeq, PubMed]; Munc18-1 Contributes to Hippocampal Injury in Septic Rats Through Regulation of Syntanxin1A and Synaptophysin and Glutamate Levels., [RefSeq, PubMed]; Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions., [UniProtKB, UniProtKB, PubMed]; STXBP1 forms amyloid-like aggregates in rat brain and demonstrates amyloid properties in bacterial expression system., [RefSeq, PubMed]; Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28208;Q62759;Q64320;Q96TG8", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0019905 syntaxin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0098888 extrinsic component of presynaptic membrane;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0061670 evoked neurotransmitter secretion;GO:0106022 positive regulation of vesicle docking;GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0002576 platelet degranulation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P61765-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63086-1", "uniprot_id": [ { "id": "MK01_RAT", "url": "https://www.uniprot.org/uniprot/P63086", "type": "external" } ], "mass": 41276.0, "length": 358, "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "Mapk1", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 1", "refseq_ac": [ { "id": "NP_446294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446294", "type": "external" } ], "gene_names_uniprotkb": "Mapk1; Erk2; Mapk; Prkm1", "gene_names_refseq": "ERK-2; ERT1; Erk2; Mapk1; p42-MAPK", "protein_names_uniprotkb": "Mitogen-activated protein kinase 1; 2.7.11.24; ERK-2; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; Mitogen-activated protein kinase 2; p42-MAPK", "protein_names_refseq": "MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; extracellular-signal-regulated kinase 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); renal fibrosis (Disease Ontology:DOID:0050855); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); Noonan syndrome 13 (Disease Ontology:DOID:0112161); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); gastric ulcer (Disease Ontology:DOID:10808); urethral obstruction (Disease Ontology:DOID:12577); velocardiofacial syndrome (Disease Ontology:DOID:12583); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); thyroid cancer (Disease Ontology:DOID:1781); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); prostate adenocarcinoma (Disease Ontology:DOID:2526); morphine dependence (Disease Ontology:DOID:2560); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); coronary restenosis (Disease Ontology:DOID:4247); Weissenbacher-Zweymuller syndrome (Disease Ontology:DOID:4258); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); childhood pilocytic astrocytoma (Disease Ontology:DOID:6812); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:116590); (R-RNO-111995); (R-RNO-112409); (R-RNO-112411); (R-RNO-1181150); (R-RNO-1295596); (R-RNO-1502540); (R-RNO-162658); (R-RNO-170968); (R-RNO-198753); (R-RNO-202670); (R-RNO-2029482); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2871796); (R-RNO-3371453); (R-RNO-375165); (R-RNO-437239); (R-RNO-445144); (R-RNO-450341); (R-RNO-456926); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5663213); (R-RNO-5668599); (R-RNO-5673001); (R-RNO-5674135); (R-RNO-5674499); (R-RNO-5675221); (R-RNO-6798695); (R-RNO-6811558); (R-RNO-74749); (R-RNO-877300); (R-RNO-881907); (R-RNO-8939211); (R-RNO-9627069); (R-RNO-9634635); (R-RNO-9634638); (R-RNO-9732724); (R-RNO-982772); (R-RNO-9856649)", "pathway_count": 46, "publication_count": 32, "publication_id_list": "11226259;12944431;15923189;16393692;16567630;16641100;16765894;1712480;18571434;18767165;19427337;19565474;19778377;2032290;21070949;21779493;22673903;24567387;27783954;29959233;36642184;37000151;37338759;38791516;39285628;7780739;7939721;8107865;8639522;9298898;9604935;9753691", "class_list": "", "function": "Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic., [RefSeq, PubMed]; Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1., [RefSeq, PubMed]; Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2, GLI1 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (By similarity). Phosphorylates GJA1 at 'Ser-279' and 'Ser-282' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (PubMed:29959233). Acts as a positive regulator of smoothened signaling by mediating phosphorylation of GLI1 in response to smoothened activation, promoting its dissociation from SUFU inhibitor and translocation to the nucleus (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 41, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27703", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": 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activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0030878 thyroid gland development;GO:0019858 cytosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P63086-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05701-1", "uniprot_id": [ { "id": "BPIB3_RAT", "url": "https://www.uniprot.org/uniprot/Q05701", "type": "external" } ], "mass": 49949.0, "length": 473, "protein_name": "BPI fold-containing family B member 3", "gene_name": "Bpifb3", "organism": "Rat", "refseq_name": "BPI fold-containing family B member 3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001424720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424720", "type": "external" } ], "gene_names_uniprotkb": "Bpifb3; Lplunc3; Rya3", "gene_names_refseq": "Bpifb3; Lplunc3; Rya3", "protein_names_uniprotkb": "BPI fold-containing family B member 3; Ligand-binding protein RYA3; Long palate, lung and nasal epithelium carcinoma-associated protein 3", "protein_names_refseq": "BPI fold-containing family B member 3 isoform 2 precursor; Long palate, lung and nasal epithelium carcinoma associated protein 3; Potential ligand-binding protein RYA3; antimicrobial peptide RYA3; long palate, lung and nasal epithelium carcinoma-associated protein 3", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1915264", "class_list": "", "function": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05701-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64649-1", "uniprot_id": [ { "id": "KPB1_RAT", "url": "https://www.uniprot.org/uniprot/Q64649", "type": "external" } ], "mass": 139155.0, "length": 1242, "protein_name": "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform", "gene_name": "Phka1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phka1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase kinase alpha M subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "glycogen storage disease IXd (Disease Ontology:DOID:0111040); hypothyroidism (Disease Ontology:DOID:1459); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:64561); (R-RNO-70221)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1512265;22673903", "class_list": "", "function": "Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64650;Q64651;Q9QZ77", "ec_number_list": [], "go_molecular_function": "GO:0004105 choline-phosphate cytidylyltransferase activity;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0006656 phosphatidylcholine biosynthetic process;GO:0046777 protein autophosphorylation;GO:0005980 glycogen catabolic process;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64649-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A096MK47-4", "uniprot_id": [ { "id": "MLIP_RAT", "url": "https://www.uniprot.org/uniprot/A0A096MK47", "type": "external" } ], "mass": 103653.0, "length": 966, "protein_name": "Muscular LMNA-interacting protein", "gene_name": "Mlip", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mlip; Cip", "gene_names_refseq": "", "protein_names_uniprotkb": "Muscular LMNA-interacting protein; CIP; Cardiac Isl1-interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 1 (Disease Ontology:DOID:0061183)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22343712;22673903;26436652", "class_list": "", "function": "Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (PubMed:22343712, PubMed:26436652). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6ARD4;D4A3C4;Q569A0", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0005521 lamin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0042383 sarcolemma", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress;GO:0010614 negative regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A096MK47-4", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62889-1", "uniprot_id": [ { "id": "NLGN3_RAT", "url": "https://www.uniprot.org/uniprot/Q62889", "type": "external" } ], "mass": 93888.0, "length": 848, "protein_name": "Neuroligin-3", "gene_name": "Nlgn3", "organism": "Rat", "refseq_name": "neuroligin-3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_599163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599163", "type": "external" } ], "gene_names_uniprotkb": "Nlgn3", "gene_names_refseq": "Nlgn3", "protein_names_uniprotkb": "Neuroligin-3; Gliotactin homolog", "protein_names_refseq": "gliotactin homolog; neuroligin-3 isoform 2 precursor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:171297); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "11329178;15152050;16982420;17897391;18755801;19914352;20624592;22673903;25565602;26621873;27805570;29393594;30790215;38843836;8576240", "class_list": "", "function": "Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system., [UniProtKB, PubMed]; E found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation., [RefSeq, PubMed]; Show that up-regulation of BiP (immunoglobulin heavy-chain-binding protein) and CHOP [C/EBP (CCAAT/enhancer-binding protein)-homologous protein] was induced by both mutant proteins but not by wild-type neuroligin3, [RefSeq, PubMed]; Studied the effect of clonal overexpression of NL3 and NL2 in neurons of the rat cerebral cortex in vivo after in utero electroporation, found that overexpression of NL3 has strong effects on GABAergic synapses and neuronal radial migration, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0097110 scaffold protein binding;GO:0042043 neurexin family protein binding;GO:0038023 signaling receptor activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030054 cell junction", "go_biological_process": "GO:0060024 rhythmic synaptic transmission;GO:0097104 postsynaptic membrane assembly;GO:2000331 regulation of terminal button organization;GO:0007612 learning;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62889-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HS7-1", "uniprot_id": [ { "id": "PDLI3_RAT", "url": "https://www.uniprot.org/uniprot/Q66HS7", "type": "external" } ], "mass": 39106.0, "length": 362, "protein_name": "PDZ and LIM domain protein 3", "gene_name": "Pdlim3", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 3", "refseq_ac": [ { "id": "NP_446102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446102", "type": "external" } ], "gene_names_uniprotkb": "Pdlim3; Alp", "gene_names_refseq": "Actn2lp; Alp; Pdlim3", "protein_names_uniprotkb": "PDZ and LIM domain protein 3; Actinin-associated LIM protein; Alpha-actinin-2-associated LIM protein; SK-2", "protein_names_refseq": "PDZ and LIM domain protein 3; SK-2; actinin alpha 2 associated LIM protein; actinin-associated LIM protein; alpha-actinin-2-associated LIM protein", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431)", "pathway": " (rno:114108)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9334352", "class_list": "", "function": "May play a role in the organization of actin filament arrays within muscle cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70208", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0008092 cytoskeletal protein binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber;GO:0030018 Z disc", "go_biological_process": "GO:0007015 actin filament organization;GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66HS7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19493-1", "uniprot_id": [ { "id": "GRIA4_RAT", "url": "https://www.uniprot.org/uniprot/P19493", "type": "external" } ], "mass": 100758.0, "length": 902, "protein_name": "Glutamate receptor 4", "gene_name": "Gria4", "organism": "Rat", "refseq_name": "glutamate receptor 4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001106655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106655", "type": "external" } ], "gene_names_uniprotkb": "Gria4; Glur4", "gene_names_refseq": "GluA4; GluR-D; GluR4; Gria4", "protein_names_uniprotkb": "Glutamate receptor 4; AMPA-selective glutamate receptor 4; GluA4; GluR-4; GluR-D; GluR4; Glutamate receptor ionotropic, AMPA 4", "protein_names_refseq": "AMPA-selective glutamate receptor 4; glutamate receptor 4 isoform 2 precursor; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4; glutamate receptor, ionotropic, AMPA4 (alpha 4)", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); depressive disorder (Disease Ontology:DOID:1596); central nervous system disease (Disease Ontology:DOID:331); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29629); (R-RNO-399710); (R-RNO-399719); (R-RNO-416993); (R-RNO-438066); (R-RNO-8849932)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "10027300;12471040;12574408;12603841;1370372;1372042;1699275;18188153;18817736;19022251;19102704;19234459;19265014;1977421;20107073;2166337;24090084;25656447;26966189;27157711;27714514;38843836;40954371", "class_list": "", "function": "Data show that PKA activation leads to insertion of GluA4 to synaptic sites with initially weak or silent AMPAR-mediated transmission. This suggests that the GluA4-mediated activation of silent synapses is a critical mechanism facilitating the functional maturation of glutamatergic circuitry during the critical period of experience-dependent fine-tuning., [RefSeq, PubMed]; Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]., [RefSeq]; Hippocampal GluA2 and GluA4 protein but not corresponding mRNA and promoter methylation levels are modulated at retrieval in spatial learning of the rat., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q64241", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004970 glutamate-gated receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0050803 regulation of synapse structure or activity;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 4.0, "record_id": "P19493-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100100010001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11980-1", "uniprot_id": [ { "id": "KPYM_RAT", "url": "https://www.uniprot.org/uniprot/P11980", "type": "external" } ], "mass": 57818.0, "length": 531, "protein_name": "Pyruvate kinase PKM", "gene_name": "Pkml1; Pkm", "organism": "Rat", "refseq_name": "pyruvate kinase PKM", "refseq_ac": [ { "id": "NP_445749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445749", "type": "external" } ], "gene_names_uniprotkb": "Pkml1; Pkm; LOC100362738; Pkm2; Pkml1; Pykm", "gene_names_refseq": "PKM12; PK; Pk3; Pkm2; Pkm", "protein_names_uniprotkb": "Pyruvate kinase PKM; 2.7.1.40; 2.7.10.2; 2.7.11.1; Pyruvate kinase muscle isozyme; Threonine-protein kinase PKM2; Tyrosine-protein kinase PKM2", "protein_names_refseq": "M2 pyruvate kinase; pyruvate kinase PKM; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; pyruvate kinase, muscle; threonine-protein kinase PKM2; tyrosine-protein kinase PKM2", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); vibratory urticaria (Disease Ontology:DOID:1554)", "pathway": " (rno:25630); (R-RNO-6798695); (R-RNO-70171); (R-RNO-70268); (R-RNO-9861718)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "18683930;22673903;2780321;2914912;3020052;34502162;37382601;37702892;38062516;38471282;39444090", "class_list": "", "function": "Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of Pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis., [RefSeq, PubMed]; Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity. In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase. Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase. Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription. Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages. May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment., [RefSeq, PubMed]; Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Silencing PKM2 Attenuates Brain Injury Induced by Status Epilepticus by Inhibiting the AKT/mTOR Pathway and the NLRP3 Inflammasome., [RefSeq, PubMed]; The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase-1/GSDMD Pathway in Neonatal Rats With Hypoxic-Ischemic Brain Injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11981", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0000287 magnesium ion binding;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:1902912 pyruvate kinase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0042866 pyruvate biosynthetic process;GO:2000767 positive regulation of cytoplasmic translation;GO:1903672 positive regulation of sprouting angiogenesis;GO:0014870 response to muscle inactivity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P11980-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62735-1", "uniprot_id": [ { "id": "NR1H4_RAT", "url": "https://www.uniprot.org/uniprot/Q62735", "type": "external" } ], "mass": 53935.0, "length": 469, "protein_name": "Bile acid receptor", "gene_name": "Nr1h4", "organism": "Rat", "refseq_name": "bile acid receptor isoform 2", "refseq_ac": [ { "id": "NP_068513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068513", "type": "external" } ], "gene_names_uniprotkb": "Nr1h4; Bar; Fxr; Rip14", "gene_names_refseq": "Fxr; Nr1h4", "protein_names_uniprotkb": "Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; RXR-interacting protein 14; Retinoid X receptor-interacting protein 14", "protein_names_refseq": "RXR-interacting protein 14; bile acid receptor isoform 2; bile acid receptor; farnesoid X-activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14", "tax_id": 10116, "disease": "progressive familial intrahepatic cholestasis 5 (Disease Ontology:DOID:0070225); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:60351); (R-RNO-159418); (R-RNO-192105); (R-RNO-193368); (R-RNO-193807); (R-RNO-211976); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 8, "publication_count": 10, "publication_id_list": "10744760;12718893;12917342;20305288;33611845;38036169;38135007;38299213;39159828;7774010", "class_list": "", "function": "Activation of farnesoid X receptor retards expansion of renal collecting duct cell-derived cysts via inhibition of CFTR-mediated Cl[-] secretion., [RefSeq, PubMed]; FXR contributes to obstructive jaundice-induced vascular hyporeactivity in mesenteric arteries by reconstituting BKCa channels., [RefSeq, PubMed]; FXR controls insulin content by regulating Foxa2-mediated insulin transcription., [RefSeq, PubMed]; FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB., [RefSeq, PubMed]; Farnesoid X receptor activation protects against renal fibrosis via modulation of beta-catenin signaling., [RefSeq, PubMed]; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity. In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). Activates transcription of the repressor MAFG (involved in regulation of BA synthesis). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression. The function also involves the coordinated induction of hepatic KLB/beta-klotho expression. Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA. Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly). Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance). Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element. Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase). Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes. Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance. Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier. Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells. Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2. Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902122 chenodeoxycholic acid binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0043235 receptor complex;GO:0000791 euchromatin", "go_biological_process": "GO:1904179 positive regulation of adipose tissue development;GO:0032703 negative regulation of interleukin-2 production;GO:0032740 positive regulation of interleukin-17 production;GO:0038185 nuclear receptor-mediated bile acid signaling pathway;GO:1905695 positive regulation of phosphatidic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62735-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88944-1", "uniprot_id": [ { "id": "KCNQ3_RAT", "url": "https://www.uniprot.org/uniprot/O88944", "type": "external" } ], "mass": 96898.0, "length": 873, "protein_name": "Potassium voltage-gated channel subfamily KQT member 3", "gene_name": "Kcnq3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnq3", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 3; KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); autistic disorder (Disease Ontology:DOID:12849); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:29682)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10684873;22673903;24349250;27979964;9836639", "class_list": "", "function": "Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24349250, PubMed:9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers, each subunit containing a voltage sensing domain (VSD) and a pore-forming domain (PD) (By similarity). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed:9836639). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z240", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:1903701 substantia propria of cornea development;GO:0098976 excitatory chemical synaptic transmission;GO:0006468 protein phosphorylation;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O88944-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15387-1", "uniprot_id": [ { "id": "KCNB1_RAT", "url": "https://www.uniprot.org/uniprot/P15387", "type": "external" } ], "mass": 95637.0, "length": 857, "protein_name": "Potassium voltage-gated channel subfamily B member 1", "gene_name": "Kcnb1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily B member 1", "refseq_ac": [ { "id": "NP_037318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037318", "type": "external" } ], "gene_names_uniprotkb": "Kcnb1", "gene_names_refseq": "DRK1PC; Kcnb1; Kcr1-1; Kv2.1; Shab", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 1; DRK1; Delayed rectifier potassium channel 1; Voltage-gated potassium channel subunit Kv2.1", "protein_names_refseq": "DRK1; delayed rectifier potassium channel 1; potassium channel Kv2.1; potassium channel, voltage gated Shab-related subfamily B, member 1; potassium voltage gated channel, Shab-related subfamily, member 1; potassium voltage-gated channel subfamily B member 1; voltage-gated potassium channel subunit Kv2.1", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); developmental and epileptic encephalopathy 26 (Disease Ontology:DOID:0080461); primary ciliary dyskinesia 1 (Disease Ontology:DOID:0110594); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:25736); (R-RNO-1296072); (R-RNO-381676)", "pathway_count": 3, "publication_count": 82, "publication_id_list": "10024359;10414301;10414968;10618149;10719893;11463864;12065754;12127166;12403834;12451110;12560340;12615930;12621036;12807875;12832499;12954870;15195093;15322114;15855232;15858231;16273079;16319318;16407566;16917065;16988031;17192433;17301173;17360683;17379638;1740690;17606996;17965280;18004376;18167541;18463252;18542995;18690023;1875913;19014551;19074135;19077057;19219384;19276663;1961744;19622611;19690160;20202934;20360102;20484665;21518833;21712386;21818121;2206531;22411134;22648171;22673903;23705070;23878373;24477962;24569993;24928958;2770868;33060203;33333928;33854181;37566068;7576642;7623158;8083226;8463836;8508921;8670833;8978827;8980147;9079713;9305895;9351973;9362476;9522360;9565597;9616203;9696692", "class_list": "", "function": "Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1. Publication Status: Online-Only, [RefSeq, PubMed]; Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity in Rat Small Superior Cerebellar Arteries. Publication Status: Online-Only, [RefSeq, PubMed]; Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvbeta1 subunit., [RefSeq, PubMed]; Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:10024359, PubMed:10618149, PubMed:12451110, PubMed:17379638, PubMed:19276663, PubMed:23878373). Also plays a role in the regulation of exocytosis independently of its electrical function (PubMed:20484665). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:12560340, PubMed:1875913, PubMed:2206531, PubMed:2770868, PubMed:8083226, PubMed:8978827, PubMed:9351973, PubMed:9565597). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20202934). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes (PubMed:8670833, PubMed:8980147, PubMed:9079713, PubMed:9305895, PubMed:9362476, PubMed:9696692). Heterotetrameric channel activity formed with KCNS3 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (PubMed:9362476). Channel properties are also modulated by cytoplasmic ancillary beta subunits such as AMIGO1, KCNE1, KCNE2 and KCNE3, slowing activation and inactivation rate of the delayed rectifier potassium channels (PubMed:12954870, PubMed:19219384). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells (PubMed:10024359, PubMed:10414968, PubMed:10618149, PubMed:11463864, PubMed:12127166, PubMed:12403834, PubMed:12451110, PubMed:12621036, PubMed:12807875, PubMed:12832499, PubMed:12954870, PubMed:15195093, PubMed:15322114, PubMed:16407566, PubMed:17301173, PubMed:17379638, PubMed:18167541, PubMed:18463252, PubMed:19276663, PubMed:20484665, PubMed:21518833, PubMed:22411134, PubMed:23878373, PubMed:9362476, PubMed:9616203). Mediates the major part of the somatodendritic delayed-rectifier potassium current in hippocampal and cortical pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation (PubMed:10618149, PubMed:12451110, PubMed:16319318, PubMed:16917065, PubMed:17379638, PubMed:19276663, PubMed:23878373). Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:11463864). Plays a role in the regulation of resting membrane potential and contraction in hypoxia-treated pulmonary artery smooth muscle cells (PubMed:9616203). May contribute to the regulation of the duration of both the action potential of cardiomyocytes and the heart ventricular repolarization QT interval (By similarity). Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury (PubMed:12832499, PubMed:16273079, PubMed:17360683, PubMed:19077057, PubMed:19622611, PubMed:24928958). May confer neuroprotection in response to hypoxia/ischemic insults by suppressing pyramidal neurons hyperexcitability in hippocampal and cortical regions (PubMed:16319318). Promotes trafficking of KCNG3, KCNH1 and KCNH2 to the cell surface membrane, presumably by forming heterotetrameric channels with these subunits (By similarity). Plays a role in the calcium-dependent recruitment and release of fusion-competent vesicles from the soma of neurons, neuroendocrine and glucose-induced pancreatic beta cells by binding key components of the fusion machinery in a pore-independent manner (PubMed:11463864, PubMed:17301173, PubMed:18167541, PubMed:20484665, PubMed:22411134)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0046982 protein heterodimerization activity;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010701 positive regulation of norepinephrine secretion;GO:0098900 regulation of action potential;GO:2000671 regulation of motor neuron apoptotic process;GO:0051260 protein homooligomerization;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 8.3, "record_id": "P15387-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62888-1", "uniprot_id": [ { "id": "NLGN2_RAT", "url": "https://www.uniprot.org/uniprot/Q62888", "type": "external" } ], "mass": 90961.0, "length": 836, "protein_name": "Neuroligin-2", "gene_name": "Nlgn2", "organism": "Rat", "refseq_name": "neuroligin-2 precursor", "refseq_ac": [ { "id": "NP_446444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446444", "type": "external" } ], "gene_names_uniprotkb": "Nlgn2", "gene_names_refseq": "Nlgn2", "protein_names_uniprotkb": "Neuroligin-2", "protein_names_refseq": "neuroligin-2 precursor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:117096); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "11329178;12141453;15620359;18334216;18434543;18755801;19755106;19859968;19914352;20624592;22528485;22673903;23248271;23751499;27805570;28279354;29742426;30602588;30790215;37865312;37955815;38843836;8576240;9647694", "class_list": "", "function": "Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation., [RefSeq, PubMed]; Study on the expression of NLGN2 in the developing and adult olfactory bulb, [RefSeq, PubMed]; These data indicate that NLGs are SNX27-retromer cargoes and suggest that SNX27-retromer controls inhibitory synapse number, at least in part through trafficking of NLG2. Publication Status: Online-Only, [RefSeq, PubMed]; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion., [UniProtKB, UniProtKB, PubMed, PubMed]; Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding;GO:0042043 neurexin family protein binding;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0072553 terminal button organization;GO:0099054 presynapse assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:1901142 insulin metabolic process;GO:0097104 postsynaptic membrane assembly", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q62888-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ50-1", "uniprot_id": [ { "id": "HGS_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ50", "type": "external" } ], "mass": 86246.0, "length": 776, "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "Hgs", "organism": "Rat", "refseq_name": "hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1", "refseq_ac": [ { "id": "NP_062260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062260", "type": "external" } ], "gene_names_uniprotkb": "Hgs; Hrs2; Hrs", "gene_names_refseq": "Hgs; Hrs", "protein_names_uniprotkb": "Hepatocyte growth factor-regulated tyrosine kinase substrate; SNAP-25-interacting protein Hrs-2", "protein_names_refseq": "HGF-regulated tyrosine kinase substrate; SNAP-25-interacting protein Hrs-2; hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:56084); (R-RNO-182971); (R-RNO-432720); (R-RNO-5689880); (R-RNO-6807004); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9013420); (R-RNO-917729); (R-RNO-9706019)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "10809762;10825299;11110793;17062640;19808888;20675381;9039916;9798906", "class_list": "", "function": "Hrs and Tsg101 as crucial regulators of trafficking of Cx43 to lysosomes., [RefSeq, PubMed]; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Nedd4-2 induces binding of ENaC to Hrs, which mediates the sorting decision between ENaC degradation and recycling., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "P97847;Q5XIV8;Q76N76", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0033565 ESCRT-0 complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0030141 secretory granule", "go_biological_process": "GO:0010324 membrane invagination;GO:0010628 positive regulation of gene expression;GO:0031623 receptor internalization;GO:0008333 endosome to lysosome transport;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JJ50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09215-1", "uniprot_id": [ { "id": "KPCD_RAT", "url": "https://www.uniprot.org/uniprot/P09215", "type": "external" } ], "mass": 77520.0, "length": 673, "protein_name": "Protein kinase C delta type", "gene_name": "Prkcd", "organism": "Rat", "refseq_name": "protein kinase C delta type", "refseq_ac": [ { "id": "NP_579841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579841", "type": "external" } ], "gene_names_uniprotkb": "Prkcd; Pkcd", "gene_names_refseq": "Pkcd; Prkcd", "protein_names_uniprotkb": "Protein kinase C delta type; 2.7.11.13; SDK1; Sphingosine-dependent protein kinase-1; nPKC-delta", "protein_names_refseq": "nPKC-delta; protein kinase C delta type", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); muscular disease (Disease Ontology:DOID:0080000); autoimmune lymphoproliferative syndrome type 3 (Disease Ontology:DOID:0110119); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); hyperinsulinism (Disease Ontology:DOID:2018); brain ischemia (Disease Ontology:DOID:2316); restrictive cardiomyopathy (Disease Ontology:DOID:397); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:170538); (R-RNO-111465); (R-RNO-111933); (R-RNO-114508); (R-RNO-1250196); (R-RNO-1489509); (R-RNO-2029485); (R-RNO-450520); (R-RNO-5218921); (R-RNO-5607764); (R-RNO-5668599); (R-RNO-6798695); (R-RNO-877300)", "pathway_count": 13, "publication_count": 23, "publication_id_list": "10708593;10721703;12855683;16396499;17562707;17569658;18295358;18550549;1915352;22371141;22673903;24107416;25359536;2834397;30641088;31257458;31908004;32291286;3691811;37611829;9045715;9677322;9687370", "class_list": "", "function": "Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as a positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. Involved in antifungal immunity by mediating phosphorylation and activation of CARD9 downstream of C-type lectin receptors activation, promoting interaction between CARD9 and BCL10, followed by activation of NF-kappa-B and MAP kinase p38 pathways (By similarity). May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin (By similarity). The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion. Phosphorylates ELAVL1 in response to angiotensin-2 treatment (By similarity). Phosphorylates mitochondrial phospholipid scramblase 3 (PLSCR3), resulting in increased cardiolipin expression on the mitochondrial outer membrane which facilitates apoptosis (By similarity). Phosphorylates SMPD1 which induces SMPD1 secretion (By similarity). Acts as a negative regulator of smoothened signaling by mediating phosphorylation of GLI1, preventing its localization to the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Chromatin immunoprecipitation revealed that AR could bind to Pkcd promoter. Our results indicate that prenatal exposure to testosterone may induce cardiac hypertrophy in adult female rats through enhanced Pkcd expression in cardiac myocytes., [RefSeq, PubMed]; Metabolic reprogramming contributes to radioprotection by protein kinase Cdelta., [RefSeq, PubMed]; Protein Kinase C-delta Mediates Kidney Tubular Injury in Cold Storage-Associated Kidney Transplantation., [RefSeq, PubMed]; Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis., [RefSeq, PubMed]; These results confirmed that CaSR activated PKCdelta to induce cardiomyocyte apoptosis through ER stressassociated apoptotic pathways during I/R in vivo., [RefSeq, PubMed]; Truncated isoform 2 is inactive., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6DG48;Q9JK29;Q9JL03", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin;GO:1900163 positive regulation of phospholipid scramblase activity;GO:2000753 positive regulation of glucosylceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P09215-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z258-1", "uniprot_id": [ { "id": "KCNT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z258", "type": "external" } ], "mass": 139788.0, "length": 1239, "protein_name": "Potassium channel subfamily T member 1", "gene_name": "Kcnt1", "organism": "Rat", "refseq_name": "potassium channel subfamily T member 1 isoform X3", "refseq_ac": [ { "id": "XP_006233761", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233761", "type": "external" } ], "gene_names_uniprotkb": "Kcnt1; Slack", "gene_names_refseq": "Kcnt1; Slack; rSlo2", "protein_names_uniprotkb": "Potassium channel subfamily T member 1; Sequence like a calcium-activated potassium channel subunit", "protein_names_refseq": "potassium channel subfamily T member 1 isoform X3", "tax_id": 10116, "disease": "autosomal dominant nocturnal frontal lobe epilepsy 5 (Disease Ontology:DOID:0060686); developmental and epileptic encephalopathy 14 (Disease Ontology:DOID:0080439); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:60444)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10196543;12442315;12628167;14684870;16045448;16687497;18787033;19403831;19412167;20512134;23086397;24463883;36898835", "class_list": "", "function": "Sodium-activated K(+) channel (PubMed:12628167, PubMed:14684870, PubMed:16687497, PubMed:24463883, PubMed:36898835). Acts as an important mediator of neuronal membrane excitability (By similarity). Contributes to the delayed outward currents (PubMed:10196543, PubMed:19412167). Regulates neuronal bursting in sensory neurons (PubMed:16687497, PubMed:18787033). Contributes to synaptic development and plasticity (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1LSG1;Q5D6C6", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity;GO:0005228 intracellular sodium-activated potassium channel activity;GO:0070089 chloride-activated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport;GO:0060078 regulation of postsynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z258-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63018-1", "uniprot_id": [ { "id": "HSP7C_RAT", "url": "https://www.uniprot.org/uniprot/P63018", "type": "external" } ], "mass": 70871.0, "length": 646, "protein_name": "Heat shock cognate 71 kDa protein", "gene_name": "Hspa8", "organism": "Rat", "refseq_name": "heat shock cognate 71 kDa protein", "refseq_ac": [ { "id": "NP_077327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077327", "type": "external" } ], "gene_names_uniprotkb": "Hspa8; Haus8l2; Hsc70; Hsc73", "gene_names_refseq": "Hsc70; Hspa8", "protein_names_uniprotkb": "Heat shock cognate 71 kDa protein; 3.6.4.10; Heat shock 70 kDa protein 8", "protein_names_refseq": "Heat shock cognate protein 70; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; heat shock protein 8; heat shock protein A8", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); graft-versus-host disease (Disease Ontology:DOID:0081267); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24468); (R-RNO-3371453); (R-RNO-3371497); (R-RNO-3371568); (R-RNO-3371571); (R-RNO-432720); (R-RNO-432722); (R-RNO-450408); (R-RNO-6798695); (R-RNO-72163); (R-RNO-8856828); (R-RNO-8876725); (R-RNO-888590); (R-RNO-9833482)", "pathway_count": 14, "publication_count": 13, "publication_id_list": "10373374;10567422;11696006;15708368;32336545;32873086;34362408;34502162;3595567;37947174;38843836;3939319;41549750", "class_list": "", "function": "Carboxyl terminus of Hsc70-interacting protein (CHIP) promotes pulmonary artery smooth muscle cell (PASMC) proliferation via enhancement of intracellular Ca(2+) concentration ([Ca(2+)]i)., [RefSeq, PubMed]; Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells., [RefSeq, PubMed]; Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-kappaB/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-3120/Hsc70 participates in forced swim stress-induced mechanical hyperalgesia in rats in an inflammatory state., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins, formation and dissociation of protein complexes, and antigen presentation. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded. In conjunction with LAMP2, facilitates MHC class II presentation of cytoplasmic antigens by guiding antigens to the lysosomal membrane for interaction with LAMP2 which then elicits MHC class II presentation of peptides to the cell membrane. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. It is recruited to clathrin-coated vesicles through its interaction with DNAJC6 leading to activation of HSPA8/HSC70 ATPase activity and therefore uncoating of clathrin-coated vesicles (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08109;P12225;Q4FZY7;Q62373;Q62374;Q62375", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": 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}, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": 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"external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "4.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.18", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0031686 A1 adenosine receptor binding;GO:0055131 C3HC4-type RING finger domain binding;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0044829 host-mediated activation of viral genome replication;GO:0061684 chaperone-mediated autophagy;GO:0061738 late endosomal microautophagy;GO:1902904 negative regulation of supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P63018-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLP1-1", "uniprot_id": [ { "id": "KHDR3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLP1", "type": "external" } ], "mass": 38779.0, "length": 346, "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "gene_name": "Khdrbs3", "organism": "Rat", "refseq_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 3", "refseq_ac": [ { "id": "NP_071585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071585", "type": "external" } ], "gene_names_uniprotkb": "Khdrbs3; Slm2", "gene_names_refseq": "Etle; Khdrbs3; Slm2", "protein_names_uniprotkb": "KH domain-containing, RNA-binding, signal transduction-associated protein 3; SLM-2; Sam68-like mammalian protein 2; rSLM-2", "protein_names_refseq": "KH domain containing, RNA binding, signal transduction associated 3; KH domain-containing, RNA-binding, signal transduction-associated protein 3; SLM-2; etoile, Sam68-like protein SLM-2; rSLM-2; sam68-like mammalian protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64015); (R-RNO-8849468)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10332027;11118435;15345239", "class_list": "", "function": "RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (PubMed:11118435). Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (By similarity). Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (PubMed:11118435). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JLP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A24-1", "uniprot_id": [ { "id": "KLH24_RAT", "url": "https://www.uniprot.org/uniprot/Q56A24", "type": "external" } ], "mass": 68364.0, "length": 600, "protein_name": "Kelch-like protein 24", "gene_name": "Klhl24", "organism": "Rat", "refseq_name": "kelch-like protein 24", "refseq_ac": [ { "id": "NP_852138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852138", "type": "external" } ], "gene_names_uniprotkb": "Klhl24; Dre1", "gene_names_refseq": "Dre1; Klhl24", "protein_names_uniprotkb": "Kelch-like protein 24; KRIP6; Kainate receptor-interacting protein for GluR6; Protein DRE1", "protein_names_refseq": "KRIP6; kainate receptor-interacting protein for GluR6; kelch-like 24; kelch-like protein 24", "tax_id": 10116, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (rno:303803)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17254796", "class_list": "", "function": "A novel neuronal protein of the BTB/kelch family, KRIP6., [RefSeq, PubMed]; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (PubMed:17254796). Has a crucial role in cardiac development and function (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q812D9", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0030424 axon;GO:0043204 perikaryon;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045109 intermediate filament organization;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q56A24-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01956-1", "uniprot_id": [ { "id": "KCNC3_RAT", "url": "https://www.uniprot.org/uniprot/Q01956", "type": "external" } ], "mass": 94393.0, "length": 889, "protein_name": "Voltage-gated potassium channel KCNC3", "gene_name": "Kcnc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcnc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-gated potassium channel KCNC3; KSHIIID; Potassium voltage-gated channel subfamily C member 3; Voltage-gated potassium channel subunit Kv3.3", "protein_names_refseq": "", "tax_id": 10116, "disease": "spinocerebellar ataxia 13 (Disease Ontology:DOID:0050963)", "pathway": " (R-RNO-1296072)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1381835;20857303;22673903", "class_list": "", "function": "Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:1381835). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis. Required for normal motor function (By similarity). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0046872 metal ion binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential;GO:0046928 regulation of neurotransmitter secretion;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01956-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZR8-1", "uniprot_id": [ { "id": "PDZD2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZR8", "type": "external" } ], "mass": 293890.0, "length": 2766, "protein_name": "PDZ domain-containing protein 2", "gene_name": "Pdzd2", "organism": "Rat", "refseq_name": "PDZ domain-containing protein 2", "refseq_ac": [ { "id": "NP_075229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075229", "type": "external" } ], "gene_names_uniprotkb": "Pdzd2; Papin; Pdzk3; Pin1", "gene_names_refseq": "Papin; Pdzd2; Pdzk3", "protein_names_uniprotkb": "PDZ domain-containing protein 2; PDZ domain-containing protein 3; Plakophilin-related armadillo repeat protein-interacting PDZ protein", "protein_names_refseq": "PDZ domain containing 3; PDZ domain-containing protein 2; PDZ domain-containing protein 3; plakophilin-related armadillo repeat protein-interacting PDZ protein", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (rno:65034)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10896674;12591166;12671685;19607921;22673903;32919022;38843836", "class_list": "", "function": "Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism., [RefSeq, PubMed]; These findings reveal that Pdzd2 and p11 play collaborative roles in regulation of Na(V)1.8 expression in sensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0007155 cell adhesion;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QZR8-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88644-1", "uniprot_id": [ { "id": "GRIFN_RAT", "url": "https://www.uniprot.org/uniprot/O88644", "type": "external" } ], "mass": 15839.0, "length": 144, "protein_name": "Grifin", "gene_name": "Grifin", "organism": "Rat", "refseq_name": "grifin", "refseq_ac": [ { "id": "NP_476535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476535", "type": "external" } ], "gene_names_uniprotkb": "Grifin", "gene_names_refseq": "Grifin", "protein_names_uniprotkb": "Grifin; Galectin-related inter-fiber protein", "protein_names_refseq": "grifin", "tax_id": 10116, "disease": "", "pathway": " (rno:117130)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9786891", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88644-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70627-1", "uniprot_id": [ { "id": "FOLH1_RAT", "url": "https://www.uniprot.org/uniprot/P70627", "type": "external" } ], "mass": 84540.0, "length": 752, "protein_name": "Glutamate carboxypeptidase 2", "gene_name": "Folh1", "organism": "Rat", "refseq_name": "glutamate carboxypeptidase 2", "refseq_ac": [ { "id": "NP_476533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476533", "type": "external" } ], "gene_names_uniprotkb": "Folh1; Naalad1", "gene_names_refseq": "Folh1; Naalad", "protein_names_uniprotkb": "Glutamate carboxypeptidase 2; 3.4.17.21; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen homolog; Pteroylpoly-gamma-glutamate carboxypeptidase; mGCP", "protein_names_refseq": "FGCP; GCPII; N-acetylated alpha-linked acidic dipeptidase; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; folylpoly-gamma-glutamate carboxypeptidase; glutamate carboxypeptidase 2; glutamate carboxypeptidase II; mGCP; membrane glutamate carboxypeptidase; prostate-specific membrane antigen homolog; pteroylpoly-gamma-glutamate carboxypeptidase", "tax_id": 10116, "disease": "cerebral infarction (Disease Ontology:DOID:3526); abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (rno:85309); (R-RNO-8963693)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15019832;22570482;22673903;24090084;30113208;38843836;8570628;9375657;9501243", "class_list": "", "function": "Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC., [UniProtKB]; Folh1 gene plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat., [RefSeq, PubMed]; Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate., [UniProtKB]; NAAG peptidase inhibition has a role in release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia, [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 3, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 2, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q547B6", "ec_number_list": [ { "id": "3.4.17.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.21", "type": "external" } ], "go_molecular_function": "GO:1904492 Ac-Asp-Glu binding;GO:1904493 tetrahydrofolyl-poly(glutamate) polymer binding;GO:0046872 metal ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0098829 intestinal folate absorption;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0030163 protein catabolic process;GO:0006760 folic acid-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P70627-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY78-1", "uniprot_id": [ { "id": "IKKB_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY78", "type": "external" } ], "mass": 86866.0, "length": 757, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit beta", "gene_name": "Ikbkb", "organism": "Rat", "refseq_name": "inhibitor of nuclear factor kappa-B kinase subunit beta", "refseq_ac": [ { "id": "NP_445807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445807", "type": "external" } ], "gene_names_uniprotkb": "Ikbkb; Ikkb", "gene_names_refseq": "AIM-1; IKK2; Ikbkb", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit beta; 2.7.11.10; 2.7.11.1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IkBKB; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; Serine/threonine protein kinase IKBKB", "protein_names_refseq": "I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; NFKBIKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa-B kinase subunit beta; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); immunodeficiency 15B (Disease Ontology:DOID:0111959); immunodeficiency 15A (Disease Ontology:DOID:0111960); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); prostate adenocarcinoma (Disease Ontology:DOID:2526); dermatitis (Disease Ontology:DOID:2723); liver cancer (Disease Ontology:DOID:3571); pneumonia (Disease Ontology:DOID:552); muscular atrophy (Disease Ontology:DOID:767); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:84351); (R-RNO-1169091); (R-RNO-1810476); (R-RNO-202424); (R-RNO-209543); (R-RNO-209560); (R-RNO-2871837); (R-RNO-445989); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5607764); (R-RNO-5684264); (R-RNO-9020702); (R-RNO-933542); (R-RNO-937039); (R-RNO-937041); (R-RNO-975144); (R-RNO-9758274); (R-RNO-9833482); (R-RNO-9860276); (R-RNO-9860927); (R-RNO-9909505)", "pathway_count": 22, "publication_count": 10, "publication_id_list": "10712233;16079148;22673903;23090968;26867315;31297885;31549412;34073390;35132967;9819420", "class_list": "", "function": "IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-kappaB signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-218 regulates diabetic nephropathy via targeting IKK-beta and modulating NK-kappaB-mediated inflammation., [RefSeq, PubMed]; Protective effect of RNA interference targeting Ikkbeta on hepatic fibrosis in rats., [RefSeq, PubMed]; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0008384 IkappaB kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0061847 response to cholecystokinin;GO:1903140 regulation of establishment of endothelial barrier;GO:1903347 negative regulation of bicellular tight junction assembly;GO:0003009 skeletal muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QY78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17659-1", "uniprot_id": [ { "id": "KCNA6_RAT", "url": "https://www.uniprot.org/uniprot/P17659", "type": "external" } ], "mass": 58884.0, "length": 530, "protein_name": "Potassium voltage-gated channel subfamily A member 6", "gene_name": "Kcna6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kcna6", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 6; RCK2; Voltage-gated potassium channel subunit Kv1.6; Voltage-gated potassium channel subunit Kv2", "protein_names_refseq": "", "tax_id": 10116, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:64358); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15618540;1993474;2347305;2361015;9334400", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:15618540, PubMed:1993474). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (Probable). Homotetrameric channels display rapid activation and slow inactivation (PubMed:1993474)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P19025", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043679 axon terminus", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P17659-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8V5-1", "uniprot_id": [ { "id": "KCNK4_RAT", "url": "https://www.uniprot.org/uniprot/G3V8V5", "type": "external" } ], "mass": 42920.0, "length": 397, "protein_name": "Potassium channel subfamily K member 4", "gene_name": "Kcnk4", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 4 isoform X2", "refseq_ac": [ { "id": "XP_008758277", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008758277", "type": "external" } ], "gene_names_uniprotkb": "Kcnk4", "gene_names_refseq": "KT4.1; Kcnk4; TRAAK", "protein_names_uniprotkb": "Potassium channel subfamily K member 4; TRAAK; TWIK-related arachidonic acid-stimulated potassium channel protein", "protein_names_refseq": "potassium channel subfamily K member 4 isoform X2", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (rno:116489); (R-RNO-1299503); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11374070;15677687;31630908", "class_list": "", "function": "K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids (PubMed:11374070, PubMed:31630908). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (PubMed:31630908). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q924I4", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0097604 temperature-gated cation channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0033268 node of Ranvier", "go_biological_process": "GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0071469 cellular response to alkaline pH;GO:0007613 memory;GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "G3V8V5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42930-1", "uniprot_id": [ { "id": "HSPB1_RAT", "url": "https://www.uniprot.org/uniprot/P42930", "type": "external" } ], "mass": 22893.0, "length": 206, "protein_name": "Heat shock protein beta-1", "gene_name": "Hspb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hspb1; Hsp27", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein beta-1; HSP 27; Heat shock 27 kDa protein; HspB1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease axonal type 2F (Disease Ontology:DOID:0110163); autosomal dominant distal hereditary motor neuronopathy 3 (Disease Ontology:DOID:0111207); Alzheimer's disease (Disease Ontology:DOID:10652); sarcoma (Disease Ontology:DOID:1115); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:24471); (R-RNO-4420097); (R-RNO-450408); (R-RNO-5687128); (R-RNO-9009391)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10751411;11546764;16641100;22673903;28657654;29393594;34502162;36642184;7916612;8282729;8793069", "class_list": "", "function": "Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63922;Q9QWA8", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0071348 cellular response to interleukin-11;GO:0002931 response to ischemia;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P42930-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35793-1", "uniprot_id": [ { "id": "GREM1_RAT", "url": "https://www.uniprot.org/uniprot/O35793", "type": "external" } ], "mass": 20680.0, "length": 184, "protein_name": "Gremlin-1", "gene_name": "Grem1", "organism": "Rat", "refseq_name": "gremlin-1 precursor", "refseq_ac": [ { "id": "NP_062155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062155", "type": "external" } ], "gene_names_uniprotkb": "Grem1; Cktsf1b1; Drm", "gene_names_refseq": "Cktsf1b1; Grem1; drm", "protein_names_uniprotkb": "Gremlin-1; Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein", "protein_names_refseq": "cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; gremlin 1 homolog, cysteine knot superfamily; gremlin-1 precursor; gremlin-1", "tax_id": 10116, "disease": "microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:50566)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15528323;31657855;32750294;34993960;35440754;37977053;9234736", "class_list": "", "function": "Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (PubMed:15528323). Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-beta-mediated Smad2/3 phosphorylation., [RefSeq, PubMed]; Gremlin aggravates periodontitis via activation of the nuclear factor-kappa B signaling pathway., [RefSeq, PubMed]; The possible role of Gremlin1 in inflammatory apical periodontitis., [RefSeq, PubMed]; Tumor-associated macrophage-derived exosomal miR-155-5p promotes intracranial aneurysm formation via GREM1., [RefSeq, PubMed]; Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity;GO:0043184 vascular endothelial growth factor receptor 2 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0051893 regulation of focal adhesion assembly;GO:0038098 sequestering of BMP from receptor via BMP binding;GO:0002689 negative regulation of leukocyte chemotaxis;GO:0046851 negative regulation of bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35793-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07335-1", "uniprot_id": [ { "id": "KCRB_RAT", "url": "https://www.uniprot.org/uniprot/P07335", "type": "external" } ], "mass": 42725.0, "length": 381, "protein_name": "Creatine kinase B-type", "gene_name": "Ckb", "organism": "Rat", "refseq_name": "creatine kinase B-type", "refseq_ac": [ { "id": "NP_036661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036661", "type": "external" } ], "gene_names_uniprotkb": "Ckb; Ckbb", "gene_names_refseq": "CPK-B; Ckbb; Ckbr; Ckb", "protein_names_uniprotkb": "Creatine kinase B-type; 2.7.3.2; B-CK; CPK-B; Creatine kinase B chain; Creatine phosphokinase M-type", "protein_names_refseq": "B-CK; brain creatine kinase; creatine kinase B chain; creatine kinase B-type; creatine kinase, brain; creatine phosphokinase M-type", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); left ventricular failure (Disease Ontology:DOID:0051064); hypertension (Disease Ontology:DOID:10763); thromboangiitis obliterans (Disease Ontology:DOID:12918); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); functional colonic disease (Disease Ontology:DOID:3877); rhinitis (Disease Ontology:DOID:4483); type 2 diabetes mellitus (Disease Ontology:DOID:9352); irritable bowel syndrome (Disease Ontology:DOID:9778); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24264); (R-RNO-71288); (R-RNO-9696264)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "18047804;1939264;22307408;22673903;2284002;23142228;23620342;2838389;3005113;6477506", "class_list": "", "function": "Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum., [RefSeq, PubMed]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The expression of CK in cochlear tissues during development may reflect differential requirements for creatine-phosphocreatine buffering to replenish ATP consumed during energy-dependent metabolic processes., [RefSeq, PubMed]; These results indicate that Hpca associates with BB-CK and that together they translocate to membrane compartments in a Ca(2+)-dependent manner., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPK7;Q499P7;Q5PPJ5;Q6IRE0;Q6P139", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0030644 intracellular chloride ion homeostasis;GO:0071391 cellular response to estrogen stimulus;GO:0021549 cerebellum development;GO:1904568 cellular response to wortmannin", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07335-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09605-1", "uniprot_id": [ { "id": "KCRS_RAT", "url": "https://www.uniprot.org/uniprot/P09605", "type": "external" } ], "mass": 47385.0, "length": 419, "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "Ckmt2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ckmt2", "gene_names_refseq": "", "protein_names_uniprotkb": "Creatine kinase S-type, mitochondrial; 2.7.3.2; Basic-type mitochondrial creatine kinase; Mib-CK; S-MtCK; Sarcomeric mitochondrial creatine kinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:688698); (R-RNO-71288)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1859839;22673903;27213235;3338460;34502162", "class_list": "", "function": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:1901612 cardiolipin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0007507 heart development;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P09605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C643-1", "uniprot_id": [ { "id": "GRP2_RAT", "url": "https://www.uniprot.org/uniprot/P0C643", "type": "external" } ], "mass": 69291.0, "length": 608, "protein_name": "RAS guanyl-releasing protein 2", "gene_name": "Rasgrp2", "organism": "Rat", "refseq_name": "RAS guanyl-releasing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001076446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076446", "type": "external" } ], "gene_names_uniprotkb": "Rasgrp2", "gene_names_refseq": "Rasgrp2", "protein_names_uniprotkb": "RAS guanyl-releasing protein 2; CalDAG-GEFI; Calcium and DAG-regulated guanine nucleotide exchange factor I", "protein_names_refseq": "RAS guanyl releasing protein 2 (calcium and DAG-regulated); RAS guanyl-releasing protein 2 isoform 1; calDAG-GEFI; calcium and DAG-regulated guanine nucleotide exchange factor I", "tax_id": 10116, "disease": "leukocyte adhesion deficiency 3 (Disease Ontology:DOID:0110912); platelet-type bleeding disorder 18 (Disease Ontology:DOID:0111051)", "pathway": " (rno:361714); (R-RNO-354192); (R-RNO-392517)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11292831;11503142;22673903;29393594;9789079", "class_list": "", "function": "Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006955 immune response;GO:0043547 positive regulation of GTPase activity;GO:0071277 cellular response to calcium ion;GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C643-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25809-1", "uniprot_id": [ { "id": "KCRU_RAT", "url": "https://www.uniprot.org/uniprot/P25809", "type": "external" } ], "mass": 47029.0, "length": 418, "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "Ckmt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ckmt1; Ckmt", "gene_names_refseq": "", "protein_names_uniprotkb": "Creatine kinase U-type, mitochondrial; 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; U-MtCK; Ubiquitous mitochondrial creatine kinase", "protein_names_refseq": "", "tax_id": 10116, "disease": "status epilepticus (Disease Ontology:DOID:1824)", "pathway": " (R-RNO-71288)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1859839;1939264;22673903", "class_list": "", "function": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0043204 perikaryon;GO:0044289 mitochondrial inner-outer membrane contact site", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0043066 negative regulation of apoptotic process;GO:0001822 kidney development;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0048565 digestive tract development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P25809-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52944-1", "uniprot_id": [ { "id": "PDLI1_RAT", "url": "https://www.uniprot.org/uniprot/P52944", "type": "external" } ], "mass": 35584.0, "length": 327, "protein_name": "PDZ and LIM domain protein 1", "gene_name": "Pdlim1", "organism": "Rat", "refseq_name": "PDZ and LIM domain protein 1", "refseq_ac": [ { "id": "NP_059061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059061", "type": "external" } ], "gene_names_uniprotkb": "Pdlim1; Clim1; Clp36", "gene_names_refseq": "CLP36; Pdlim1", "protein_names_uniprotkb": "PDZ and LIM domain protein 1; C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36", "protein_names_refseq": "C-terminal LIM domain protein 1; LIM domain protein CLP-36; LIM protein; PDZ and LIM domain protein 1; elfin", "tax_id": 10116, "disease": "", "pathway": " (rno:54133)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17964547;20599268;22659164;22673903;38334094;8522188", "class_list": "", "function": "Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (PubMed:22659164)., [UniProtKB, UniProtKB, PubMed]; Decreased PDLIM1 expression in endothelial cells contributes to the development of intracranial aneurysm., [RefSeq, PubMed]; Expression linked to the differentiation of Rcho-1 cells, [RefSeq, PubMed]; The CLP36 has a redundant role in the formation of stress fibers, but have different effects on stress fiber dynamics in F2408 cells., [RefSeq, PubMed]; These findings indicate that CLP36 plays a critical role in stress fiber formation and the assembly of focal adhesions in BeWo cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6IN45", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0001666 response to hypoxia;GO:0030036 actin cytoskeleton organization;GO:0030950 establishment or maintenance of actin cytoskeleton polarity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P52944-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61374-1", "uniprot_id": [ { "id": "ISL1_RAT", "url": "https://www.uniprot.org/uniprot/P61374", "type": "external" } ], "mass": 39036.0, "length": 349, "protein_name": "Insulin gene enhancer protein ISL-1", "gene_name": "Isl1", "organism": "Rat", "refseq_name": "insulin gene enhancer protein ISL-1", "refseq_ac": [ { "id": "NP_059035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059035", "type": "external" } ], "gene_names_uniprotkb": "Isl1", "gene_names_refseq": "Isl-1; Isl1; isl-1=homeobox", "protein_names_uniprotkb": "Insulin gene enhancer protein ISL-1; Islet-1", "protein_names_refseq": "ISL1 transcription factor LIM/homeodomain (islet-1); ISL1 transcription factor, LIM/homeodomain 1; insulin gene enhancer protein ISL-1; isl-1 homeobox; islet-1", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); myocardial infarction (Disease Ontology:DOID:5844); double outlet right ventricle (Disease Ontology:DOID:6406); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:64444)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1691825;38819467;7907017", "class_list": "", "function": "DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (PubMed:1691825). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity)., [UniProtKB, UniProtKB]; Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20663;P47894", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0045880 positive regulation of smoothened signaling pathway;GO:0060384 innervation;GO:0021520 spinal cord motor neuron cell fate specification;GO:0021524 visceral motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P61374-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62198-1", "uniprot_id": [ { "id": "PRS8_RAT", "url": "https://www.uniprot.org/uniprot/P62198", "type": "external" } ], "mass": 45626.0, "length": 406, "protein_name": "26S proteasome regulatory subunit 8", "gene_name": "Psmc5", "organism": "Rat", "refseq_name": "26S proteasome regulatory subunit 8", "refseq_ac": [ { "id": "NP_112411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112411", "type": "external" } ], "gene_names_uniprotkb": "Psmc5; Sug1", "gene_names_refseq": "Psmc5; Sug1", "protein_names_uniprotkb": "26S proteasome regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; TRIP1; Thyroid hormone receptor-interacting protein 1; p45/SUG", "protein_names_refseq": "26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; TRIP1; for proteasomal ATPase (SUG1); peptidase (prosome, macropain) 26S subunit, ATPase 5; protease (prosome, macropain) 26S subunit, ATPase 5; proteasomal ATPase (SUG1); proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome p45/SUG; proteasome subunit p45; thyroid hormone receptor-interacting protein 1", "tax_id": 10116, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:81827); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 56, "publication_count": 6, "publication_id_list": "32731408;32770803;38124005;7776974;8607789;9370298", "class_list": "", "function": "Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypoxia-induced increase in Sug1 leads to poor post-transplantation survival of allogeneic mesenchymal stem cells., [RefSeq, PubMed]; Phosphorylation of RPT6 Controls Its Ability to Bind DNA and Regulate Gene Expression in the Hippocampus of Male Rats during Memory Formation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35051;P47210;P52915;P52916", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0140296 general transcription initiation factor binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0031595 nuclear proteasome complex;GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0090261 positive regulation of inclusion body assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62198-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQL7-1", "uniprot_id": [ { "id": "ITM2C_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQL7", "type": "external" } ], "mass": 30480.0, "length": 269, "protein_name": "Integral membrane protein 2C", "gene_name": "Itm2c", "organism": "Rat", "refseq_name": "integral membrane protein 2C", "refseq_ac": [ { "id": "NP_001009674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009674", "type": "external" } ], "gene_names_uniprotkb": "Itm2c", "gene_names_refseq": "Itm2c", "protein_names_uniprotkb": "Integral membrane protein 2C", "protein_names_refseq": "integral membrane protein 2C; integral membrane protein 3", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 7 (Disease Ontology:DOID:0080462); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); heart conduction disease (Disease Ontology:DOID:10273); benign neonatal seizures (Disease Ontology:DOID:14264); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:301575)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0030182 neuron differentiation;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5PQL7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920B6-1", "uniprot_id": [ { "id": "KCNK2_RAT", "url": "https://www.uniprot.org/uniprot/Q920B6", "type": "external" } ], "mass": 46912.0, "length": 426, "protein_name": "Potassium channel subfamily K member 2", "gene_name": "Kcnk2", "organism": "Rat", "refseq_name": "potassium channel subfamily K member 2 isoform 1", "refseq_ac": [ { "id": "NP_742038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742038", "type": "external" } ], "gene_names_uniprotkb": "Kcnk2; Trek", "gene_names_refseq": "Kcnk2; Trek-1; rTREK1d", "protein_names_uniprotkb": "Potassium channel subfamily K member 2; Outward rectifying potassium channel protein TREK-1; Stretch-activated potassium channel TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1", "protein_names_refseq": "TREK-1 K(+) channel subunit; arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; outward rectifying potassium channel protein TREK-1; potassium channel subfamily K member 2 isoform 1; potassium channel subfamily K member 2; potassium channel, two pore domain subfamily K, member 2; stretch-activated potassium channel TREK-1; tandem-pore-domain potassium channel TREK-1; two pore domain potassium channel TREK-1; two pore potassium channel TPKC1", "tax_id": 10116, "disease": "heart conduction disease (Disease Ontology:DOID:10273); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:170899); (R-RNO-1299503); (R-RNO-5576886)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11319556;11897838;16248991;19571146;23021213;24196565;26919430;31630908;31959866;32439217;33006141;36650581;37184053", "class_list": "", "function": "Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier. Publication Status: Online-Only, [RefSeq, PubMed]; Does not display channel activity but reduces the channel activity of isoform 1, isoform 2 and isoform 4 and reduces cell surface expression of isoform 2., [UniProtKB, PubMed]; K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Reversibly converts between a voltage-insensitive K(+) 'leak' channel and a voltage-dependent outward rectifying K(+) channel in a phosphorylation-dependent manner (PubMed:11319556, PubMed:16248991, PubMed:19571146, PubMed:24196565, PubMed:26919430). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:24196565). In trigeminal ganglia sensory neurons, the heterodimer of KCNK2/TREK-1 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (PubMed:31630908). In hippocampal astrocytes, the heterodimer of KCNK2/TREK-1 and KCNK1/TWIK-1 allows passive K(+) conductance under basal conditions, but changes ion selectivity and becomes permeable to L-glutamate and Cl(-) ions upon binding to G protein subunit GNG4 in stimulated astrocytes. Mediates rapid L-glutamate release in response to activation of G protein-coupled receptors such as F2R and CNR1 (PubMed:23021213). In hippocampal pyramidal neurons, the homodimer of KCNK2/TREK-1 contributes to gamma-aminobutyric acid (GABA) B-induced slow inhibitory postsynaptic potential. Associates with AKAP5 and Gs-protein-coupled receptor B2AR at postsynaptic dense bodies and converts to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Permeable to other monovalent cations such as Rb(+) and Cs(+) (PubMed:26919430)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naive and neuropathic rats., [RefSeq, PubMed]; Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice Disorders., [RefSeq, PubMed]; The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A3QR52;Q3MMY3;Q5DNW4;Q5DNW5", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0098782 mechanosensitive potassium channel activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0003231 cardiac ventricle development;GO:1900039 positive regulation of cellular response to hypoxia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q920B6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M64-1", "uniprot_id": [ { "id": "P4K2A_RAT", "url": "https://www.uniprot.org/uniprot/Q99M64", "type": "external" } ], "mass": 54305.0, "length": 478, "protein_name": "Phosphatidylinositol 4-kinase type 2-alpha", "gene_name": "Pi4k2a", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-kinase type 2-alpha", "refseq_ac": [ { "id": "NP_446187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446187", "type": "external" } ], "gene_names_uniprotkb": "Pi4k2a; Pi4kii", "gene_names_refseq": "Pi4KII; Pi4k2a", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-alpha; 2.7.1.67; 55 kDa type II phosphatidylinositol 4-kinase; Phosphatidylinositol 4-kinase type II-alpha", "protein_names_refseq": "55 kDa type II phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:114554); (R-RNO-1660499); (R-RNO-1660514); (R-RNO-1660516)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11244087;12215430;12471042;16641100;19581584;21998198;22673903;32463939", "class_list": "", "function": "Defined the minimal catalytic domain and identified conserved amino acid residues required for catalysis, [RefSeq, PubMed]; GSK-3beta regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIalpha., [RefSeq, PubMed]; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)., [UniProtKB, PubMed]; This enzyme is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0035651 AP-3 adaptor complex binding;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035838 growing cell tip;GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005768 endosome", "go_biological_process": "GO:0002561 basophil degranulation;GO:0007032 endosome organization;GO:0006661 phosphatidylinositol biosynthetic process;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99M64-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHZ4-1", "uniprot_id": [ { "id": "GRAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHZ4", "type": "external" } ], "mass": 96074.0, "length": 837, "protein_name": "GRIP1-associated protein 1", "gene_name": "Gripap1", "organism": "Rat", "refseq_name": "GRIP1-associated protein 1", "refseq_ac": [ { "id": "NP_446259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446259", "type": "external" } ], "gene_names_uniprotkb": "Gripap1; Grasp1", "gene_names_refseq": "Grasp1; Gripap1", "protein_names_uniprotkb": "GRIP1-associated protein 1; 30kDa C-terminus form; GRASP-1", "protein_names_refseq": "GRASP-1; GRIP-associated protein 1; GRIP1-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:116493)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10896157;17761173;20098723;22673903;34245609", "class_list": "", "function": "Functions as a scaffold protein in neurons to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity., [UniProtKB, PubMed]; GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons., [RefSeq, PubMed]; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHZ3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:1903828 negative regulation of protein localization;GO:0099152 regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0099158 regulation of recycling endosome localization within postsynapse;GO:1903910 negative regulation of receptor clustering", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHZ4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ40-1", "uniprot_id": [ { "id": "NHRF3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ40", "type": "external" } ], "mass": 56800.0, "length": 523, "protein_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3", "gene_name": "Pdzk1", "organism": "Rat", "refseq_name": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3", "refseq_ac": [ { "id": "NP_113900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113900", "type": "external" } ], "gene_names_uniprotkb": "Pdzk1; Clamp; Diphor1; Nherf3", "gene_names_refseq": "Clamp; Pdzk1", "protein_names_uniprotkb": "Na(+)/H(+) exchange regulatory cofactor NHE-RF3; C-terminal-linking and modulating protein; Dietary Pi-regulated RNA-1; Diphor-1; NHERF-3; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3", "protein_names_refseq": "C-terminal linking and modulating protein; NHERF-3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchanger regulatory factor 3; PDZ domain-containing protein 1; dietary Pi-regulated RNA-1; diphor-1; na/Pi cotransporter C-terminal-associated protein 1; naPi-Cap1; sodium-hydrogen exchanger regulatory factor 3", "tax_id": 10116, "disease": "hypophosphatemic nephrolithiasis/osteoporosis 2 (Disease Ontology:DOID:0080078)", "pathway": " (rno:65144)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10829064;15994332;16054660;16174736;22673903;37696999;9374845", "class_list": "", "function": "A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons., [UniProtKB, PubMed]; Oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function, [RefSeq, PubMed]; PDZK1 improves ventricular remodeling in hypertensive rats by regulating the stability of the Mas receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35234;Q6AZ21", "ec_number_list": [], "go_molecular_function": "GO:0005124 scavenger receptor binding;GO:0005102 signaling receptor binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0072659 protein localization to plasma membrane;GO:0090314 positive regulation of protein targeting to membrane;GO:0030301 cholesterol transport;GO:1902603 carnitine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJ40-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU74-1", "uniprot_id": [ { "id": "LSR_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU74", "type": "external" } ], "mass": 65777.0, "length": 593, "protein_name": "Lipolysis-stimulated lipoprotein receptor", "gene_name": "Lsr", "organism": "Rat", "refseq_name": "lipolysis-stimulated lipoprotein receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_116005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116005", "type": "external" } ], "gene_names_uniprotkb": "Lsr; Lisch7", "gene_names_refseq": "Lisch7; Lsr", "protein_names_uniprotkb": "Lipolysis-stimulated lipoprotein receptor; Lipolysis-stimulated remnant receptor", "protein_names_refseq": "lipolysis-stimulated lipoprotein receptor isoform 2 precursor; lipolysis-stimulated receptor; lipolysis-stimulated remnant receptor; liver-specific bHLH-Zip transcription factor 7", "tax_id": 10116, "disease": "", "pathway": " (rno:64355)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10224102;22673903;35463981", "class_list": "", "function": "Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (PubMed:10224102). Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q497B9;Q9WU75;Q9WU76", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0017129 triglyceride binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0061833 protein localization to tricellular tight junction;GO:1904274 tricellular tight junction assembly;GO:0001889 liver development;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WU74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H17-1", "uniprot_id": [ { "id": "SPT32_RAT", "url": "https://www.uniprot.org/uniprot/Q66H17", "type": "external" } ], "mass": 38580.0, "length": 348, "protein_name": "Spermatogenesis-associated protein 32", "gene_name": "Efcab15; Spata32", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 32", "refseq_ac": [ { "id": "NP_001005531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005531", "type": "external" } ], "gene_names_uniprotkb": "Efcab15; Spata32; Aep2; Efcab15; LOC100361655; Spata32; Vad1.2", "gene_names_refseq": "RGD1359156; Spata32; Tex34; Vad1.2", "protein_names_uniprotkb": "Spermatogenesis-associated protein 32; Acrosome expressed protein 2", "protein_names_refseq": "acrosome expressed protein 2; spermatogenesis-associated protein 32; testis expressed 34", "tax_id": 10116, "disease": "", "pathway": " (rno:100361655); (rno:287747)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18621766;22673903", "class_list": "", "function": "Data suggest that VAD1.2 maybe involved in acrosome formation during spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H17-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4C0-1", "uniprot_id": [ { "id": "FMO5_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4C0", "type": "external" } ], "mass": 60056.0, "length": 533, "protein_name": "Flavin-containing monooxygenase 5", "gene_name": "Fmo5", "organism": "Rat", "refseq_name": "flavin-containing monooxygenase 5", "refseq_ac": [ { "id": "NP_653340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653340", "type": "external" } ], "gene_names_uniprotkb": "Fmo5", "gene_names_refseq": "Fmo5", "protein_names_uniprotkb": "Flavin-containing monooxygenase 5; 1.14.13.8; 1.6.3.1; Dimethylaniline monooxygenase [N-oxide-forming] 5; Dimethylaniline oxidase 5; FMO 5; Hepatic flavin-containing monooxygenase 5; NADPH oxidase", "protein_names_refseq": "FMO 5; NADPH oxidase; NAPDH oxidase; dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline oxidase 5; flavin containing monooxygenase 5; flavin-containing monooxygenase 5; hepatic flavin-containing monooxygenase 5", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (rno:246248)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15047867", "class_list": "", "function": "Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters., [UniProtKB, UniProtKB, UniProtKB]; Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRL0", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0090181 regulation of cholesterol metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4C0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1X1-1", "uniprot_id": [ { "id": "ESYT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1X1", "type": "external" } ], "mass": 121159.0, "length": 1088, "protein_name": "Extended synaptotagmin-1", "gene_name": "Esyt1", "organism": "Rat", "refseq_name": "extended synaptotagmin-1", "refseq_ac": [ { "id": "NP_058945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058945", "type": "external" } ], "gene_names_uniprotkb": "Esyt1; Fam62a; Mbc2", "gene_names_refseq": "Esyt1; Fam62a; Mbc2", "protein_names_uniprotkb": "Extended synaptotagmin-1; E-Syt1; Membrane-bound C2 domain-containing protein; vp115", "protein_names_refseq": "E-Syt1; extended synaptotagmin protein 1; extended synaptotagmin-1; extended synaptotagmin-like protein 1; family with sequence similarity 62 (C2 domain containing), member A; membrane bound C2 domain containing protein; vp115", "tax_id": 10116, "disease": "", "pathway": " (rno:29579); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034); (R-RNO-9845576)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10350628;22673903;29393594", "class_list": "", "function": "Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G-protein-coupled receptor activity in absence of cytosolic calcium. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1L3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0120009 intermembrane lipid transfer;GO:0061817 endoplasmic reticulum-plasma membrane tethering", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z1X1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07953-1", "uniprot_id": [ { "id": "F261_RAT", "url": "https://www.uniprot.org/uniprot/P07953", "type": "external" } ], "mass": 54763.0, "length": 471, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1", "gene_name": "Pfkfb1", "organism": "Rat", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform 1", "refseq_ac": [ { "id": "NP_036753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036753", "type": "external" } ], "gene_names_uniprotkb": "Pfkfb1", "gene_names_refseq": "PFRX; Pfkfb01; Pfkfb1", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; PFK/FBPase 1", "protein_names_refseq": "6-PF2-K/Fru-2,6-P2ase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1 isoform 1; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; PFK2/FBPase2", "tax_id": 10116, "disease": "hyperinsulinism (Disease Ontology:DOID:2018)", "pathway": " (rno:24638); (R-RNO-9634600)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "22668829;22673903;23291237;2539378;2547611;2549541;2557623;2557826;2826464;2848802;2856848;28706006;3032183;3040762;7549867;8634242;9253407", "class_list": "", "function": "A new mRNA variant which are transcribed from a new Pfkfb1 gene promoter in fetal rat liver was characterized., [RefSeq, PubMed]; Data suggest that a major portion of intracellular glucose in cardiac myocytes is apportioned for ancillary biosynthetic reactions; PFKFB1 coordinates activities of pentose phosphate, hexosamine biosynthetic, and fatty acid/glycerolipid synthesis pathways by directly modulating glycolytic intermediate entry into auxiliary glucose metabolism pathways and by indirectly regulating mitochondrial cataplerosis. Erratum:[Biochem J. 2017 Dec 14;474(24):4271-4272. doi: 10.1042/BCJ20170474_COR. PMID: 29242383] Publication Status: Online-Only, [RefSeq, PubMed]; Flexible kinase interaction mode exists, suggesting dimer conformation mediated coupling of hormonal and posttranslational enzyme regulation to the metabolic response in liver, [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P16119", "ec_number_list": [ { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" }, { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0032024 positive regulation of insulin secretion;GO:0042594 response to starvation;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P07953-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63604-1", "uniprot_id": [ { "id": "NTRK2_RAT", "url": "https://www.uniprot.org/uniprot/Q63604", "type": "external" } ], "mass": 92186.0, "length": 821, "protein_name": "BDNF/NT-3 growth factors receptor", "gene_name": "Ntrk2", "organism": "Rat", "refseq_name": "BDNF/NT-3 growth factors receptor isoform 2 precursor", "refseq_ac": [ { "id": "NP_001156640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156640", "type": "external" } ], "gene_names_uniprotkb": "Ntrk2; Trkb", "gene_names_refseq": "Ntrk2; RATTRKB1; TRKB1; Tkrb; trk-B; trkB", "protein_names_uniprotkb": "BDNF/NT-3 growth factors receptor; 2.7.10.1; Neurotrophic tyrosine kinase receptor type 2; Trk-B; TrkB tyrosine kinase", "protein_names_refseq": "BDNF/NT-3 growth factors receptor isoform 2 precursor; BDNF/NT-3 growth factors receptor; GP145-TrkB/GP95-TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; trkB tyrosine kinase", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); developmental and epileptic encephalopathy 58 (Disease Ontology:DOID:0080285); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); trigeminal neuralgia (Disease Ontology:DOID:12098); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); glaucoma (Disease Ontology:DOID:1686); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); post-traumatic stress disorder (Disease Ontology:DOID:2055); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); borna disease (Disease Ontology:DOID:5154); intestinal disease (Disease Ontology:DOID:5295); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); vascular dementia (Disease Ontology:DOID:8725); cannabis abuse (Disease Ontology:DOID:9505); diabetic neuropathy (Disease Ontology:DOID:9743); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25054); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9026527); (R-RNO-9028731); (R-RNO-9032759)", "pathway_count": 6, "publication_count": 32, "publication_id_list": "10.1039/D0MO00044B;10092678;10196222;10985347;12471037;15167895;16223723;1645620;1846020;21775604;22345308;22563458;22710915;24090084;24103847;24260264;24662915;25344640;28005701;28572757;33352241;34106099;35365447;37252844;37298449;38347284;38843836;8106527;8627351;9582017;9856458;9927421", "class_list": "", "function": "DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons., [RefSeq, PubMed]; Effects of Tail Pinch on BDNF and trkB Expression in the Hippocampus of Roman Low- (RLA) and High-Avoidance (RHA) Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Inflammation/NF-kappaB and BDNF/TrkB/CREB Pathways in the Cerebellum Are Implicated in the Changes in Spatial Working Memory After Both Morphine Dependence and Withdrawal in Rat., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 37, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q63605;Q63606", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0043121 neurotrophin binding;GO:0060175 brain-derived neurotrophic factor receptor activity;GO:0002020 protease binding;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0042490 mechanoreceptor differentiation;GO:0001570 vasculogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 5.0, "record_id": "Q63604-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31977-1", "uniprot_id": [ { "id": "EZRI_RAT", "url": "https://www.uniprot.org/uniprot/P31977", "type": "external" } ], "mass": 69391.0, "length": 586, "protein_name": "Ezrin", "gene_name": "Ezr", "organism": "Rat", "refseq_name": "ezrin", "refseq_ac": [ { "id": "NP_062230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062230", "type": "external" } ], "gene_names_uniprotkb": "Ezr; Vil2", "gene_names_refseq": "Ezr; Vil2", "protein_names_uniprotkb": "Ezrin; Cytovillin; Villin-2; p81", "protein_names_refseq": "cytovillin; ezrin; p81; villin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:54319); (R-RNO-373752); (R-RNO-437239)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11163215;11457882;15797715;22673903;28077322;29393594;30654004;31931020;34502162;38843836;7640303", "class_list": "", "function": "Ezrin associates with Cx43 (in complex with ZO-1) which places PKA in proximity to Cx43, enabling its phosphorylation and gap junction opening., [RefSeq, PubMed]; Ezrin interacts with L-periaxin by the ''head to head and tail to tail'' mode and influences the location of L-periaxin in Schwann cell RSC96., [RefSeq, PubMed]; In a model of a polycystic ovarian syndrome (PCOS)-like condition in rats through treatment with xenoestrogens (Bisphenol S and DHEA), Ezrin expression was found de be increased in the endometrium and highly located in the cytoplasm of intraepithelial lumina., [RefSeq, PubMed]; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5WQV4;Q66H97;Q8VHK3", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0044393 microspike;GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0001951 intestinal D-glucose absorption;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0022614 membrane to membrane docking;GO:0030033 microvillus assembly", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P31977-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R3-1", "uniprot_id": [ { "id": "FRMD8_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R3", "type": "external" } ], "mass": 51782.0, "length": 466, "protein_name": "FERM domain-containing protein 8", "gene_name": "Frmd8", "organism": "Rat", "refseq_name": "FERM domain-containing protein 8", "refseq_ac": [ { "id": "NP_001008349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008349", "type": "external" } ], "gene_names_uniprotkb": "Frmd8", "gene_names_refseq": "Frmd8; RGD1310323", "protein_names_uniprotkb": "FERM domain-containing protein 8", "protein_names_refseq": "FERM domain-containing protein 8; FKSG44 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:309172)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0032760 positive regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2R3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BND0-1", "uniprot_id": [ { "id": "ENPP6_RAT", "url": "https://www.uniprot.org/uniprot/B0BND0", "type": "external" } ], "mass": 50701.0, "length": 440, "protein_name": "Glycerophosphocholine cholinephosphodiesterase ENPP6", "gene_name": "Enpp6", "organism": "Rat", "refseq_name": "glycerophosphocholine cholinephosphodiesterase ENPP6 precursor", "refseq_ac": [ { "id": "NP_001402007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402007", "type": "external" } ], "gene_names_uniprotkb": "Enpp6", "gene_names_refseq": "E-NPP 6; Enpp6", "protein_names_uniprotkb": "Glycerophosphocholine cholinephosphodiesterase ENPP6; 3.1.4.-; 3.1.4.38; Choline-specific glycerophosphodiester phosphodiesterase; E-NPP 6; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; GPC-Cpde; NPP-6", "protein_names_refseq": "E-NPP6; GPC-Cpde; NPP-6; choline-specific glycerophosphodiester phosphodiesterase; ectonucleotide pyrophosphatase/phosphodiesterase family member 6-like; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; glycerophosphocholine cholinephosphodiesterase ENPP6 precursor; glycerophosphocholine cholinephosphodiesterase ENPP6", "tax_id": 10116, "disease": "", "pathway": " (rno:306460); (R-RNO-6814848)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;24090084", "class_list": "", "function": "Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0047390 glycerophosphocholine cholinephosphodiesterase activity;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B0BND0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10959-1", "uniprot_id": [ { "id": "EST1C_RAT", "url": "https://www.uniprot.org/uniprot/P10959", "type": "external" } ], "mass": 60175.0, "length": 549, "protein_name": "Carboxylesterase 1C", "gene_name": "Ces1c", "organism": "Rat", "refseq_name": "carboxylesterase 1C precursor", "refseq_ac": [ { "id": "NP_058700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058700", "type": "external" } ], "gene_names_uniprotkb": "Ces1c; Es2", "gene_names_refseq": "Ces1c; Es1; Es2", "protein_names_uniprotkb": "Carboxylesterase 1C; 3.1.1.1; Carboxyesterase ES-1; E1; ES-THET; Esterase-2; Liver carboxylesterase 1; NREH; Neutral retinyl ester hydrolase; REH; Retinyl ester hydrolase", "protein_names_refseq": "E1; ES-THET; Esterase 2 member of carboxylesterase-cluster 1; NREH; REH; carboxyesterase ES-1; carboxylesterase 1C precursor; esterase 1; esterase 2, member of carboxylesterase-cluster 1; esterase-2; liver carboxylesterase 1; microsomal carboxyesterase E1-like; neutral retinyl ester hydrolase; retinyl ester hydrolase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); stomach cancer (Disease Ontology:DOID:10534); gastrointestinal system cancer (Disease Ontology:DOID:3119); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24346)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15794950;22673903;2973315;3235453;8006016;9305911", "class_list": "", "function": "Es2 was induced by dexamethasone in liver microsomes and identified in plasma., [RefSeq, PubMed]; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant (By similarity)., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0K0;Q63106;Q64626", "ec_number_list": [ { "id": "3.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.67", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0050253 retinyl-palmitate esterase activity;GO:0106435 carboxylesterase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005811 lipid droplet", "go_biological_process": "GO:0019626 short-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10959-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62986-1", "uniprot_id": [ { "id": "ESR2_RAT", "url": "https://www.uniprot.org/uniprot/Q62986", "type": "external" } ], "mass": 59152.0, "length": 530, "protein_name": "Estrogen receptor beta", "gene_name": "Esr2", "organism": "Rat", "refseq_name": "estrogen receptor beta", "refseq_ac": [ { "id": "NP_036886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036886", "type": "external" } ], "gene_names_uniprotkb": "Esr2; Erbeta; Nr3a2", "gene_names_refseq": "ER-beta; ERbeta; Erb2; Esr2", "protein_names_uniprotkb": "Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2", "protein_names_refseq": "estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); X-linked spermatogenic failure 8 (Disease Ontology:DOID:0070599); ovarian dysgenesis 8 (Disease Ontology:DOID:0080500); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); male infertility (Disease Ontology:DOID:12336); Graves' disease (Disease Ontology:DOID:12361); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); cystitis (Disease Ontology:DOID:1679); aortic valve stenosis (Disease Ontology:DOID:1712); melanoma (Disease Ontology:DOID:1909); anxiety disorder (Disease Ontology:DOID:2030); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myasthenia gravis (Disease Ontology:DOID:437); pulmonary hypertension (Disease Ontology:DOID:6432); adenoma (Disease Ontology:DOID:657); rheumatoid arthritis (Disease Ontology:DOID:7148); peritonitis (Disease Ontology:DOID:8283); osteoarthritis (Disease Ontology:DOID:8398); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); alopecia (Disease Ontology:DOID:987); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25149); (R-RNO-1257604); (R-RNO-383280); (R-RNO-6811558); (R-RNO-8939211); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "11818503;19423554;21808025;34416391;34463394;34638689;38111056;38607081;8650195;9492041;9600083", "class_list": "", "function": "ERbeta Regulation of Gonadotropin Responses during Folliculogenesis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; ERbeta Regulation of Indian Hedgehog Expression in the First Wave of Ovarian Follicles. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of pubertal onset on region-specific Esr2 expression., [RefSeq, PubMed]; Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action., [UniProtKB, PubMed]; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner., [UniProtKB, PubMed, PubMed, UniProtKB]; Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains. Publication Status: Online-Only, [RefSeq, PubMed]; Sex-specific effects of 17beta-estradiol and dihydrotestosterone (DHT) on growth plate chondrocytes are dependent on both ERalpha and ERbeta and require palmitoylation to translocate the receptors to the plasma membrane., [RefSeq, PubMed]; Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 41, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35784;O35785;O55015;O55016;O70195;Q9R185", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0043025 neuronal cell body", "go_biological_process": "GO:0060743 epithelial cell maturation involved in prostate gland development;GO:2000252 negative regulation of feeding behavior;GO:0048521 negative regulation of behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62986-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62786-1", "uniprot_id": [ { "id": "FPRP_RAT", "url": "https://www.uniprot.org/uniprot/Q62786", "type": "external" } ], "mass": 98731.0, "length": 879, "protein_name": "Prostaglandin F2 receptor negative regulator", "gene_name": "Ptgfrn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptgfrn; Fprp", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin F2 receptor negative regulator; CD9 partner 1; CD9P-1; EWI-F; Glu-Trp-Ile EWI motif-containing protein F; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); cerebrooculofacioskeletal syndrome 3 (Disease Ontology:DOID:0080913); xeroderma pigmentosum group G (Disease Ontology:DOID:0110849); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); melanoma (Disease Ontology:DOID:1909); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:29602)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;38843836;8804121;8951995", "class_list": "", "function": "Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0034389 lipid droplet organization;GO:0014905 myoblast fusion involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62786-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02692-1", "uniprot_id": [ { "id": "FABPL_RAT", "url": "https://www.uniprot.org/uniprot/P02692", "type": "external" } ], "mass": 14273.0, "length": 127, "protein_name": "Fatty acid-binding protein, liver", "gene_name": "Fabp1", "organism": "Rat", "refseq_name": "fatty acid-binding protein, liver", "refseq_ac": [ { "id": "NP_036688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036688", "type": "external" } ], "gene_names_uniprotkb": "Fabp1", "gene_names_refseq": "Fabp1; Fabplg; L-FABP; SCP.; SCP; p14", "protein_names_uniprotkb": "Fatty acid-binding protein, liver; Fatty acid-binding protein 1; L-FABP; Liver-type fatty acid-binding protein; SCP; Squalene- and sterol-carrier protein; Z-protein; p14", "protein_names_refseq": "Z-protein; fatty acid binding protein 1, liver; fatty acid-binding protein, liver; liver-type fatty acid-binding protein; squalene- and sterol-carrier protein", "tax_id": 10116, "disease": "congenital adrenal insufficiency (Disease Ontology:DOID:0050546); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); hypogonadism (Disease Ontology:DOID:1924); nephrosis (Disease Ontology:DOID:2527); IgA glomerulonephritis (Disease Ontology:DOID:2986); hyperglycemia (Disease Ontology:DOID:4195); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24360); (R-RNO-163560); (R-RNO-189483); (R-RNO-400206); (R-RNO-9707564)", "pathway_count": 5, "publication_count": 19, "publication_id_list": "17927211;1898328;1939124;22673903;23658011;24140341;25732850;27117865;3007511;32405506;3478711;37076661;3838749;3840724;6298233;6641731;7084456;8117116;9054409", "class_list": "", "function": "L-FABP structurally and functionally interacts with HNF4alpha., [RefSeq, PubMed]; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity)., [UniProtKB, UniProtKB, PubMed]; Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced. Review article, [RefSeq, PubMed]; These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG, [RefSeq, PubMed]; Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051978 lysophospholipid:sodium symporter activity;GO:0070538 oleic acid binding;GO:0003682 chromatin binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0071926 endocannabinoid signaling pathway;GO:0097017 renal protein absorption;GO:1904659 D-glucose transmembrane transport;GO:0035733 hepatic stellate cell activation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P02692-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06494-1", "uniprot_id": [ { "id": "ERBB2_RAT", "url": "https://www.uniprot.org/uniprot/P06494", "type": "external" } ], "mass": 138832.0, "length": 1257, "protein_name": "Receptor tyrosine-protein kinase erbB-2", "gene_name": "Erbb2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Erbb2; Neu", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor tyrosine-protein kinase erbB-2; 2.7.10.1; Epidermal growth factor receptor-related protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2; p185neu", "protein_names_refseq": "", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); ductal carcinoma in situ (Disease Ontology:DOID:0060074); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); WHIM syndrome 1 (Disease Ontology:DOID:0060591); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); urinary bladder cancer (Disease Ontology:DOID:11054); osteoporosis (Disease Ontology:DOID:11476); dilated cardiomyopathy (Disease Ontology:DOID:12930); HELLP syndrome (Disease Ontology:DOID:13133); lung cancer (Disease Ontology:DOID:1324); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); rectum cancer (Disease Ontology:DOID:1993); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); larynx cancer (Disease Ontology:DOID:2596); laryngeal carcinoma (Disease Ontology:DOID:2600); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); osteosarcoma (Disease Ontology:DOID:3347); mammary Paget's disease (Disease Ontology:DOID:3443); invasive lobular carcinoma (Disease Ontology:DOID:3457); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); hemangioblastoma (Disease Ontology:DOID:5241); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); leukopenia (Disease Ontology:DOID:615); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (R-RNO-1227986); (R-RNO-1250196); (R-RNO-1257604); (R-RNO-1306955); (R-RNO-1358803); (R-RNO-1963640); (R-RNO-1963642); (R-RNO-416572); (R-RNO-5673001); (R-RNO-6785631); (R-RNO-6811558); (R-RNO-8847993); (R-RNO-8863795); (R-RNO-9652282)", "pathway_count": 14, "publication_count": 10, "publication_id_list": "12610629;1346763;1682063;2025425;21454685;21779410;22673903;25025983;3945311;7945309", "class_list": "", "function": "In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 60, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q6P732", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004713 protein tyrosine kinase activity;GO:0004888 transmembrane signaling receptor activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0038127 ERBB signaling pathway;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06494-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07483-1", "uniprot_id": [ { "id": "FABPH_RAT", "url": "https://www.uniprot.org/uniprot/P07483", "type": "external" } ], "mass": 14775.0, "length": 133, "protein_name": "Fatty acid-binding protein, heart", "gene_name": "Fabp3", "organism": "Rat", "refseq_name": "fatty acid-binding protein, heart", "refseq_ac": [ { "id": "NP_077076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077076", "type": "external" } ], "gene_names_uniprotkb": "Fabp3", "gene_names_refseq": "Fabp3", "protein_names_uniprotkb": "Fatty acid-binding protein, heart; Fatty acid-binding protein 3; H-FABP; Heart-type fatty acid-binding protein", "protein_names_refseq": "Fatty acid binding protein 3 heart; H-FABP; fatty acid binding protein 3, muscle and heart; fatty acid-binding protein, heart; heart fatty acid binding protein; heart-type fatty acid-binding protein", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Down syndrome (Disease Ontology:DOID:14250); congenital heart disease (Disease Ontology:DOID:1682); myocardial infarction (Disease Ontology:DOID:5844); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:79131); (R-RNO-163560)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10561574;2005132;22673903;2424895;26590355;2775193;2806260;3036869;3162235;34142475;3415652;3427112;34866110;35509154;8117746", "class_list": "", "function": "Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP., [RefSeq, PubMed]; FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters., [UniProtKB]; Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming, [RefSeq, PubMed]; Skin Ultrastructure and the Changes of HIF-2alpha, H-FABP Expression in the Myocardium of Electric Shock Death Rats., [RefSeq, PubMed]; Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY04", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0050543 icosatetraenoic acid binding;GO:0070538 oleic acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016528 sarcoplasm", "go_biological_process": "GO:2001245 regulation of phosphatidylcholine biosynthetic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0050873 brown fat cell differentiation;GO:0046320 regulation of fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P07483-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20395-1", "uniprot_id": [ { "id": "FSHR_RAT", "url": "https://www.uniprot.org/uniprot/P20395", "type": "external" } ], "mass": 77681.0, "length": 692, "protein_name": "Follicle-stimulating hormone receptor", "gene_name": "Fshr", "organism": "Rat", "refseq_name": "follicle-stimulating hormone receptor precursor", "refseq_ac": [ { "id": "NP_954707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954707", "type": "external" } ], "gene_names_uniprotkb": "Fshr", "gene_names_refseq": "Fshr", "protein_names_uniprotkb": "Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor", "protein_names_refseq": "FSH-R; follicle-stimulating hormone receptor precursor; follitropin receptor", "tax_id": 10116, "disease": "ovarian dysgenesis 1 (Disease Ontology:DOID:0080493); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450); granulosa cell tumor (Disease Ontology:DOID:2999); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425)", "pathway": " (rno:25449); (R-RNO-375281)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12850288;16870304;1738373;2126341;28605466;31352176;7776966", "class_list": "", "function": "G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways., [UniProtKB, UniProtKB]; Hypothyroidism changes CYP51 and FSHR expression in ovary, which are regulated by gonadotropin. Moreover, genes changes in ovary are at least partially attributed to steroids biosynthesis., [RefSeq, PubMed]; The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q64183", "ec_number_list": [], "go_molecular_function": "GO:0004963 follicle-stimulating hormone receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0001545 primary ovarian follicle growth;GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20395-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47875-1", "uniprot_id": [ { "id": "CSRP1_RAT", "url": "https://www.uniprot.org/uniprot/P47875", "type": "external" } ], "mass": 20613.0, "length": 193, "protein_name": "Cysteine and glycine-rich protein 1", "gene_name": "Csrp1", "organism": "Rat", "refseq_name": "cysteine and glycine-rich protein 1", "refseq_ac": [ { "id": "NP_058844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058844", "type": "external" } ], "gene_names_uniprotkb": "Csrp1; Csrp", "gene_names_refseq": "Csrp1; Csrp", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 1; CRP1; CRP; Cysteine-rich protein 1", "protein_names_refseq": "CRP1; CRP; Csrp 1; cysteine and glycine-rich protein 1; cysteine rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29276)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;7816640", "class_list": "", "function": "Could play a role in neuronal development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0007399 nervous system development;GO:0045214 sarcomere organization;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P47875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52555-1", "uniprot_id": [ { "id": "ERP29_RAT", "url": "https://www.uniprot.org/uniprot/P52555", "type": "external" } ], "mass": 28575.0, "length": 260, "protein_name": "Endoplasmic reticulum resident protein 29", "gene_name": "Erp29", "organism": "Rat", "refseq_name": "endoplasmic reticulum resident protein 29 precursor", "refseq_ac": [ { "id": "NP_446413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446413", "type": "external" } ], "gene_names_uniprotkb": "Erp29", "gene_names_refseq": "Erp29", "protein_names_uniprotkb": "Endoplasmic reticulum resident protein 29; ERp29; ERp31; Endoplasmic reticulum resident protein 31", "protein_names_refseq": "ERp31; endoplasmic reticulum protein ERp29; endoplasmic reticulum resident protein 29 precursor; endoplasmic reticulum resident protein 29; endoplasmic reticulum resident protein 31; endoplasmic retuclum protein 29", "tax_id": 10116, "disease": "", "pathway": " (rno:117030)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10727933;11435111;12475965;15572350;24512454;24794144;25204493;9037184;9492298", "class_list": "", "function": "Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER., [UniProtKB]; ERp29 can improve locomotor function by promoting neuronal survival and axonal regeneration in spinal cord transection rats via caspase and Erk signal pathway., [RefSeq, PubMed]; ERp29 was first identified as a BPA-binding protein but is not involved in the T3 response of GH3 cells, [RefSeq, PubMed]; Overexpression of ERp29 in cortical neurons after axotomy increased expression of Erk-1 and PI3K while decreasing the expression of caspase-3 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P80749;Q5BKC2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum;GO:0009986 cell surface;GO:0042470 melanosome", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52555-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55053-1", "uniprot_id": [ { "id": "FABP5_RAT", "url": "https://www.uniprot.org/uniprot/P55053", "type": "external" } ], "mass": 15059.0, "length": 135, "protein_name": "Fatty acid-binding protein 5", "gene_name": "Fabp5", "organism": "Rat", "refseq_name": "fatty acid-binding protein 5", "refseq_ac": [ { "id": "NP_665885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665885", "type": "external" } ], "gene_names_uniprotkb": "Fabp5", "gene_names_refseq": "C-FABP; DA11; E-FABP; Fabp5", "protein_names_uniprotkb": "Fatty acid-binding protein 5; C-FABP; Cutaneous fatty acid-binding protein; DA11; E-FABP; Epidermal-type fatty acid-binding protein; Fatty acid-binding protein, epidermal", "protein_names_refseq": "cutaneous fatty acid-binding protein; epidermal-type fatty acid-binding protein; fatty acid binding protein 5, epidermal; fatty acid-binding protein 5; fatty acid-binding protein, epidermal", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:140868); (R-RNO-163560); (R-RNO-5362517); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "10965032;22673903;29393594;30485159;35650684;37747506;38035977;7607553;8166694;8723767", "class_list": "", "function": "FABP5 promotes the budding of particles approximately 150 nm in diameter and modulates the kinetics of the SAR1 GTPase cycle., [RefSeq, PubMed]; Fatty acid binding protein 5 inhibition attenuates pronociceptive cytokine/chemokine expression and suppresses osteoarthritis pain: A comparative human and rat study., [RefSeq, PubMed]; Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex., [RefSeq, PubMed]; Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction., [RefSeq, PubMed]; Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97757", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0042802 identical protein binding;GO:0001972 retinoic acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0098921 retrograde trans-synaptic signaling by endocannabinoid;GO:1990379 lipid transport across blood-brain barrier;GO:0031392 regulation of prostaglandin biosynthetic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P55053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84039-1", "uniprot_id": [ { "id": "ENPP5_RAT", "url": "https://www.uniprot.org/uniprot/P84039", "type": "external" } ], "mass": 54290.0, "length": 477, "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "gene_name": "Enpp5", "organism": "Rat", "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor", "refseq_ac": [ { "id": "NP_001012762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012762", "type": "external" } ], "gene_names_uniprotkb": "Enpp5", "gene_names_refseq": "E-NPP 5; Enpp5; Npp5", "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; 3.1.-.-; E-NPP 5; NPP-5", "protein_names_refseq": "E-NPP5; NPP-5; ectonucleotide pyrophosphatase/phosphodiesterase 5; ectonucleotide pyrophosphatase/phosphodiesterase family member 5 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:316249)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12927778;38843836", "class_list": "", "function": "Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (By similarity). May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro (PubMed:12927778)., [UniProtKB, UniProtKB, PubMed]; NPP-5 is a neural oligomannosidic glycoprotein that may participate in neural cell communications., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5EAN9", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P84039-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85845-1", "uniprot_id": [ { "id": "FSCN1_RAT", "url": "https://www.uniprot.org/uniprot/P85845", "type": "external" } ], "mass": 54491.0, "length": 493, "protein_name": "Fascin", "gene_name": "Fscn1", "organism": "Rat", "refseq_name": "fascin", "refseq_ac": [ { "id": "NP_001094276", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094276", "type": "external" } ], "gene_names_uniprotkb": "Fscn1", "gene_names_refseq": "Fascin; Fscn1", "protein_names_uniprotkb": "Fascin", "protein_names_refseq": "fascin homolog 1, actin bundling protein; fascin", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); common bile duct neoplasm (Disease Ontology:DOID:4608); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:683788)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "18683930;19343716;22155786;22673903;25159326;27169557;29052088;38449390;8769857", "class_list": "", "function": "Actin-binding protein that contains 2 major actin binding sites (PubMed:8769857). Organizes filamentous actin into parallel bundles (PubMed:8769857). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity)., [UniProtKB, UniProtKB, PubMed]; Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that fascin 1 is involved in localization of actin-bundling proteins paladin and Eps8 (EGF receptor pathway substrate 8) during spermatogenesis; thus, fascin 1 regulates cytoskeletal filaments in Sertoli cells and in spermatid polarity., [RefSeq, PubMed]; Filopodia formation by crosslinking of F-actin with fascin in two different binding manners, [RefSeq, PubMed]; SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy., [RefSeq, PubMed]; That Fascin-1 increased rapidly in dorsal root ganglions and spinal cord after chronic constriction injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DEI1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0044393 microspike;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction", "go_biological_process": "GO:0030046 parallel actin filament bundle assembly;GO:0035089 establishment of apical/basal cell polarity;GO:0001889 liver development;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P85845-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03114-1", "uniprot_id": [ { "id": "CDK5_RAT", "url": "https://www.uniprot.org/uniprot/Q03114", "type": "external" } ], "mass": 33254.0, "length": 292, "protein_name": "Cyclin-dependent kinase 5", "gene_name": "Cdk5", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 5", "refseq_ac": [ { "id": "NP_543161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543161", "type": "external" } ], "gene_names_uniprotkb": "Cdk5; Cdkn5; PSSALRE", "gene_names_refseq": "Cdk5", "protein_names_uniprotkb": "Cyclin-dependent kinase 5; 2.7.11.1; Cell division protein kinase 5; Cyclin-dependent-like kinase 5; Serine/threonine-protein kinase PSSALRE; TPKII catalytic subunit; Tau protein kinase II catalytic subunit", "protein_names_refseq": "TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent kinase 5; cyclin-dependent-like kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231); Alzheimer's disease (Disease Ontology:DOID:10652); trigeminal neuralgia (Disease Ontology:DOID:12098); depressive disorder (Disease Ontology:DOID:1596); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:140908); (R-RNO-180024); (R-RNO-399956); (R-RNO-6804756); (R-RNO-9841922)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "1279696;1358458;14521924;14586172;17143272;18498738;21457712;22870316;23699505;23954626;27316643;28919853;30158515;30688049;32666227;32883957;33423166;35069828;35795154;36854738", "class_list": "", "function": "CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP()., [RefSeq, PubMed]; CDK5 Mediates Proinflammatory Effects of Microglia through Activated DRP1 Phosphorylation in Rat Model of Intracerebral Hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]; Cdk5 mediates rotational force-induced brain injury. Publication Status: Online-Only, [RefSeq, PubMed]; Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway. Erratum:[Mol Cell Biochem. 2021 Aug;476(8):3217. doi: 10.1007/s11010-021-04212-3. PMID: 34156588], [RefSeq, PubMed]; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (PubMed:23699505). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0006886 intracellular protein transport;GO:0006913 nucleocytoplasmic transport;GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q03114-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q157S1-1", "uniprot_id": [ { "id": "CRTC1_RAT", "url": "https://www.uniprot.org/uniprot/Q157S1", "type": "external" } ], "mass": 66924.0, "length": 630, "protein_name": "CREB-regulated transcription coactivator 1", "gene_name": "Crtc1", "organism": "Rat", "refseq_name": "CREB-regulated transcription coactivator 1", "refseq_ac": [ { "id": "NP_001040580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040580", "type": "external" } ], "gene_names_uniprotkb": "Crtc1; Mect1; Torc1", "gene_names_refseq": "Crtc1; Mect1; TORC-1; TORC1", "protein_names_uniprotkb": "CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; Transducer of CREB protein 1; Transducer of regulated cAMP response element-binding protein 1", "protein_names_refseq": "CREB-regulated transcription coactivator 1; mucoepidermoid carcinoma translocated 1; mucoepidermoid carcinoma translocated protein 1 homolog; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein 1", "tax_id": 10116, "disease": "major depressive disorder (Disease Ontology:DOID:1470); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:684527)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17183642;17360587;19244510;26844388;27383213;27766766;31157869;34274327", "class_list": "", "function": "A specific deletion of mTOR in Sertoli cells was found to cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of rpS6), but not total rpS6, and was associated with blood-testis barrier disruption, epithelial damage, loss of cell polarity, and infertility., [RefSeq, PubMed]; Depolarization (which produced a robust increase in Ca(2+) signals) together with cAMP signaling resulted in a synergistic induction of Pacap mRNA through calcineurin and its substrate, cAMP-response element-binding protein (CREB)-regulated transcription coactivator 1., [RefSeq, PubMed]; Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Abeta oligomer-induced long-term synaptic plasticity and memory impairment., [RefSeq, PubMed]; Our results provide evidence that CREB cofactor CRTC1 translocates into the nucleus of a distinct subset of hippocampal neurons during and following status epilepticus, [RefSeq, PubMed]; Overexpressing a dominant-negative form of TORC1 or down-regulating TORC1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons. Publication Status: Online-Only, [RefSeq, PubMed]; TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus, [RefSeq, PubMed]; TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons., [RefSeq, PubMed]; The PI3K/AKT pathway in the nucleus accumbens (NAc) of rodents plays a role in the molecular and behavioral adaptations that are induced by alcohol, and that in turn drives alcohol-drinking behaviors., [RefSeq, PubMed]; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008140 cAMP response element binding protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1902631 negative regulation of membrane hyperpolarization;GO:0006351 DNA-templated transcription;GO:0007613 memory;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q157S1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63430-1", "uniprot_id": [ { "id": "CSDC2_RAT", "url": "https://www.uniprot.org/uniprot/Q63430", "type": "external" } ], "mass": 16877.0, "length": 154, "protein_name": "Cold shock domain-containing protein C2", "gene_name": "Csdc2", "organism": "Rat", "refseq_name": "cold shock domain-containing protein C2", "refseq_ac": [ { "id": "NP_001164013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164013", "type": "external" } ], "gene_names_uniprotkb": "Csdc2; Pippin", "gene_names_refseq": "Csdc2; Pippin", "protein_names_uniprotkb": "Cold shock domain-containing protein C2; RNA-binding protein PIPPin", "protein_names_refseq": "RNA-binding protein pippin; cold shock domain containing C2, RNA binding; cold shock domain-containing protein C2", "tax_id": 10116, "disease": "", "pathway": " (rno:266600)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10446180;10923677;12767259;17053029;22673903;30078185;8573167", "class_list": "", "function": "Data show that only recombinant proteins that contain all the putative PIPPin domains show RNA-binding ability., [RefSeq, PubMed]; RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain., [UniProtKB, PubMed]; Significant difference among euthyroid and hypothyroid newborn rats concerns sumoylation of nuclear PIPPin, which is abolished by hypothyroidism, [RefSeq, PubMed]; Uterine suppression of CSDC2 through intrauterine-injected-specific small interfering RNA (siRNA) led to abnormal decidualization in early pregnancy, with more extended antimesometrial area and with poor M development if compared with control siRNA-injected animals. These results suggest that CSDC2 could be a regulator during decidua development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63430-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H16-1", "uniprot_id": [ { "id": "FSIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H16", "type": "external" } ], "mass": 49568.0, "length": 438, "protein_name": "Fibrous sheath-interacting protein 1", "gene_name": "Fsip1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fsip1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrous sheath-interacting protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296074)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0007338 single fertilization;GO:0048873 homeostasis of number of cells within a tissue;GO:0060271 cilium assembly;GO:0006900 vesicle budding from membrane;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H16-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q792Q4-1", "uniprot_id": [ { "id": "CRIPT_RAT", "url": "https://www.uniprot.org/uniprot/Q792Q4", "type": "external" } ], "mass": 11271.0, "length": 101, "protein_name": "Cysteine-rich PDZ-binding protein", "gene_name": "Cript", "organism": "Rat", "refseq_name": "cysteine-rich PDZ-binding protein", "refseq_ac": [ { "id": "NP_063972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063972", "type": "external" } ], "gene_names_uniprotkb": "Cript", "gene_names_refseq": "Cript", "protein_names_uniprotkb": "Cysteine-rich PDZ-binding protein; Cysteine-rich interactor of PDZ three; Cysteine-rich interactor of PDZ3", "protein_names_refseq": "cysteine-rich PDZ-binding protein; cysteine-rich interactor of PDZ three; cysteine-rich interactor of PDZ3; postsynaptic protein Cript", "tax_id": 10116, "disease": "Rothmund-Thomson syndrome (Disease Ontology:DOID:2732)", "pathway": " (rno:56725)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10570482;32157575;9581762", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (PubMed:10570482, PubMed:9581762)., [UniProtKB, PubMed, PubMed, UniProtKB]; Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0031122 cytoplasmic microtubule organization;GO:1902897 regulation of postsynaptic density protein 95 clustering;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q792Q4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4T5-1", "uniprot_id": [ { "id": "GRASP_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4T5", "type": "external" } ], "mass": 42321.0, "length": 394, "protein_name": "General receptor for phosphoinositides 1-associated scaffold protein", "gene_name": "Tamalin", "organism": "Rat", "refseq_name": "general receptor for phosphoinositides 1-associated scaffold protein", "refseq_ac": [ { "id": "NP_620249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620249", "type": "external" } ], "gene_names_uniprotkb": "Tamalin; Grasp", "gene_names_refseq": "Grasp; Tamalin", "protein_names_uniprotkb": "General receptor for phosphoinositides 1-associated scaffold protein; 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein; GRP1-associated scaffold protein; PSD-95 PDZ domain-containing protein; Tamalin", "protein_names_refseq": "95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein; GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; GRP1-associated scaffold protein; Grp1 (general receptor for phosphoinositides)-associated scaffold protein; PSD-95 PDZ domain-containing protein; general receptor for phosphoinositides 1 associated scaffold protein; general receptor for phosphoinositides 1-associated scaffold protein", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:192254)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11850456;12586822;15173175;22569042;22673903;22980744", "class_list": "", "function": "Our results suggest that spinal SGK1 phosphorylation, which subsequently triggers the GRASP-1/Rab4 cascade, plays a pivotal role in CFA-induced inflammatory pain by regulating GluR1-containing AMPAR recycling in the dorsal horn., [RefSeq, PubMed]; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses., [UniProtKB, PubMed]; Tamalin interacts with multiple neuronal proteins and several scaffold proteins in the brain through its distinct evolutionarily-conserved protein-binding domains; and tamalin mRNA is developmentally up-regulated at the postnatal period., [RefSeq, PubMed]; Tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion, [RefSeq, PubMed]; These results suggest that Tamalin is responsible for neuronal dendritic development via regulation of EFA6A/Arf6-mediated cytoskeleton dynamics., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0045211 postsynaptic membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8R4T5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPV5-1", "uniprot_id": [ { "id": "APAF_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPV5", "type": "external" } ], "mass": 141152.0, "length": 1249, "protein_name": "Apoptotic protease-activating factor 1", "gene_name": "Apaf1", "organism": "Rat", "refseq_name": "apoptotic protease-activating factor 1", "refseq_ac": [ { "id": "NP_076469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076469", "type": "external" } ], "gene_names_uniprotkb": "Apaf1", "gene_names_refseq": "Apaf1", "protein_names_uniprotkb": "Apoptotic protease-activating factor 1; APAF-1", "protein_names_refseq": "apaf-1; apoptotic protease-activating factor 1", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:78963); (R-RNO-111458); (R-RNO-111459); (R-RNO-6798695); (R-RNO-9627069)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "11567033;31212066;34304702", "class_list": "", "function": "CARD9 protects cardiomyocytes from apoptosis by interacting with Apaf-1 and interfering with apoptosome formation following myocardial ischemia/reperfusion injury in vivo and in vitro, [RefSeq, PubMed]; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP., [UniProtKB, UniProtKB, UniProtKB]; PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway., [RefSeq, PubMed]; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0043531 ADP binding;GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043293 apoptosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0030154 cell differentiation;GO:0030900 forebrain development;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EPV5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QVC8-1", "uniprot_id": [ { "id": "FKBP4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QVC8", "type": "external" } ], "mass": 51450.0, "length": 458, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP4", "gene_name": "Fkbp4", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP4", "refseq_ac": [ { "id": "NP_001178792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178792", "type": "external" } ], "gene_names_uniprotkb": "Fkbp4; Fkbp52", "gene_names_refseq": "FKBP-4; FKBP-52; Fkbp4; p59", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP4; 5.2.1.8; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506-binding protein 4; FKBP-4; FKBP-52; FKBP59; HBI; HSP-binding immunophilin; Immunophilin FKBP52; PPIase FKBP4; Rotamase; p59", "protein_names_refseq": "52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 52; FK506-binding protein 4; FKBP52 protein; FKBP59; HBI; HSP-binding immunophilin; PPIase FKBP4; immunophilin FKBP52; peptidyl-prolyl cis-trans isomerase FKBP4; rotamase", "tax_id": 10116, "disease": "androgen insensitivity syndrome (Disease Ontology:DOID:4674)", "pathway": " (rno:260321); (R-RNO-3371497); (R-RNO-3371568); (R-RNO-8939211); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "1376003;17435176;18683930;20133804;29393594;30483787;31540954", "class_list": "", "function": "Data demonstrate that FKBP52 associates with TRPC3 via an as-yet-undescribed binding site in the C-terminus of TRPC3 and modulates TRPC3-dependent Ca(2+) signals in a PPIase-dependent manner. This functional interaction might be crucial for limiting TRPC3-dependent signaling during chronic hypertrophic stimulation. Publication Status: Online-Only, [RefSeq, PubMed]; Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. May have a protective role against oxidative stress in mitochondria (By similarity). Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening., [UniProtKB, PubMed, PubMed]; The upregulation of cochaperone FKBP52 may mediate the activation of AR through the MAPK/ERK pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IM14;Q8K3U8", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0031072 heat shock protein binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031111 negative regulation of microtubule polymerization or depolymerization;GO:0046661 male sex differentiation;GO:0006463 steroid hormone receptor complex assembly;GO:0010977 negative regulation of neuron projection development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QVC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LP64-1", "uniprot_id": [ { "id": "TRIPC_RAT", "url": "https://www.uniprot.org/uniprot/F1LP64", "type": "external" } ], "mass": 223928.0, "length": 2025, "protein_name": "E3 ubiquitin-protein ligase TRIP12", "gene_name": "Trip12", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIP12", "refseq_ac": [ { "id": "NP_001026829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026829", "type": "external" } ], "gene_names_uniprotkb": "Trip12", "gene_names_refseq": "Gtl6; TRIP-12; Trip12", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIP12; 2.3.2.26; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; TRIP-12; Thyroid receptor-interacting protein 12", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIP12; HECT-type E3 ubiquitin transferase TRIP12; TR-interacting protein 12; gene trap locus 6; probable E3 ubiquitin-protein ligase TRIP12; thyroid receptor-interacting protein 12", "tax_id": 10116, "disease": "Clark-Baraitser syndrome (Disease Ontology:DOID:0080234); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:316575); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LP79;Q497C1;Q5I0I0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LP64-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R063-1", "uniprot_id": [ { "id": "PRDX5_RAT", "url": "https://www.uniprot.org/uniprot/Q9R063", "type": "external" } ], "mass": 22179.0, "length": 213, "protein_name": "Peroxiredoxin-5, mitochondrial", "gene_name": "Prdx5", "organism": "Rat", "refseq_name": "peroxiredoxin-5, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_446062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446062", "type": "external" } ], "gene_names_uniprotkb": "Prdx5", "gene_names_refseq": "Aoeb166; Prdx5", "protein_names_uniprotkb": "Peroxiredoxin-5, mitochondrial; 1.11.1.24; AOEB166; Antioxidant enzyme B166; PLP; Peroxiredoxin V; Peroxisomal antioxidant enzyme; Prx-V; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5", "protein_names_refseq": "PLP; antioxidant enzyme B166; peroxiredoxin V; peroxiredoxin-5, mitochondrial isoform 1 precursor; peroxiredoxin-5, mitochondrial; peroxisomal and mitochondrial; peroxisomal antioxidant enzyme; prx-V; thioredoxin peroxidase PMP20; thioredoxin reductase; thioredoxin-dependent peroxiredoxin 5", "tax_id": 10116, "disease": "common cold (Disease Ontology:DOID:10459)", "pathway": " (rno:113898); (R-RNO-3299685); (R-RNO-5628897)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10521424;22673903;24044889;26872211;29393594;31375973;31861721", "class_list": "", "function": "IMS-PRDX5 expression also attenuates the increase in cytosolic [Ca(2+)] in PASMCs during hypoxia., [RefSeq, PubMed]; Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Prdx5 protects TGF-beta induced fibrosis. Prdx5 negatively modulates TGF-beta induced Stat3 activation. Publication Status: Online-Only, [RefSeq, PubMed]; The role of a key metabolic integrator coenzyme A (CoA) in modulating the activity of Prdx5 was investigated., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q68G22", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding;GO:0072541 peroxynitrite reductase activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:2001057 reactive nitrogen species metabolic process;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0032967 positive regulation of collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9R063-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H76-1", "uniprot_id": [ { "id": "PAXI_RAT", "url": "https://www.uniprot.org/uniprot/Q66H76", "type": "external" } ], "mass": 64019.0, "length": 586, "protein_name": "Paxillin", "gene_name": "Pxn", "organism": "Rat", "refseq_name": "paxillin isoform X9", "refseq_ac": [ { "id": "XP_063127613", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063127613", "type": "external" } ], "gene_names_uniprotkb": "Pxn", "gene_names_refseq": "Pxn", "protein_names_uniprotkb": "Paxillin", "protein_names_refseq": "paxillin isoform X9", "tax_id": 10116, "disease": "", "pathway": " (rno:360820); (R-RNO-180292); (R-RNO-4420097); (R-RNO-445355); (R-RNO-446343); (R-RNO-446388); (R-RNO-8849471)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "11134073;11774284;12853963;14970194;15911746;16546139;16641100;20829364;21357465;22673903;28743335", "class_list": "", "function": "Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0038191 neuropilin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0018108 peptidyl-tyrosine phosphorylation;GO:0045766 positive regulation of angiogenesis;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q66H76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63544-1", "uniprot_id": [ { "id": "SYUG_RAT", "url": "https://www.uniprot.org/uniprot/Q63544", "type": "external" } ], "mass": 12976.0, "length": 123, "protein_name": "Gamma-synuclein", "gene_name": "Sncg", "organism": "Rat", "refseq_name": "gamma-synuclein", "refseq_ac": [ { "id": "NP_113876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113876", "type": "external" } ], "gene_names_uniprotkb": "Sncg", "gene_names_refseq": "Sncg", "protein_names_uniprotkb": "Gamma-synuclein; Persyn; Sensory neuron synuclein", "protein_names_refseq": "gamma-synuclein; persyn; sensory neuron synuclein; synuclein, gamma (breast cancer-specific protein 1)", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); retinoblastoma (Disease Ontology:DOID:768); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:64347)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19692427;20579003;22673903;37487948;7673161;9801372", "class_list": "", "function": "Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects., [RefSeq, PubMed]; Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6R2I0", "ec_number_list": [], "go_molecular_function": "GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:1903136 cuprous ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0014059 regulation of dopamine secretion;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63544-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62739-1", "uniprot_id": [ { "id": "RAB3I_RAT", "url": "https://www.uniprot.org/uniprot/Q62739", "type": "external" } ], "mass": 51032.0, "length": 460, "protein_name": "Rab-3A-interacting protein", "gene_name": "Rab3ip", "organism": "Rat", "refseq_name": "rab-3A-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_059009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059009", "type": "external" } ], "gene_names_uniprotkb": "Rab3ip; Rabin3; Rabin8", "gene_names_refseq": "RABIN3; Rab3ip", "protein_names_uniprotkb": "Rab-3A-interacting protein; Rab3A-interacting protein; Rabin-3; SSX2-interacting protein", "protein_names_refseq": "SSX2-interacting protein; rab-3A-interacting protein isoform 1; rab-3A-interacting protein; rab3A-interacting protein; rabin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:29885); (R-RNO-5620912); (R-RNO-5620916); (R-RNO-5620922); (R-RNO-8876198)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12221131;22673903;7532276", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (By similarity). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with RAB11A and FIP3/RAB11FIP3, parts of the ciliary targeting complex that promotes preciliary vesicle trafficking to mother centriole and ciliogenesis initiation. Part of the ciliary targeting complex containing Rab11, ASAP1, RAB3IP and RAB11FIP3 and ARF4 that promotes RAB3IP preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L127", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0030027 lamellipodium", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0060271 cilium assembly;GO:0051490 negative regulation of filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62739-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV50-1", "uniprot_id": [ { "id": "RFX2_RAT", "url": "https://www.uniprot.org/uniprot/B2GV50", "type": "external" } ], "mass": 76537.0, "length": 692, "protein_name": "DNA-binding protein RFX2", "gene_name": "Rfx2", "organism": "Rat", "refseq_name": "DNA-binding protein RFX2 isoform 2", "refseq_ac": [ { "id": "NP_001100347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100347", "type": "external" } ], "gene_names_uniprotkb": "Rfx2", "gene_names_refseq": "Rfx2", "protein_names_uniprotkb": "DNA-binding protein RFX2; Regulatory factor X 2", "protein_names_refseq": "DNA-binding protein RFX2 isoform 2; DNA-binding protein RFX2; regulatory factor X 2; regulatory factor X, 2 (influences HLA class II expression)", "tax_id": 10116, "disease": "", "pathway": " (rno:301121)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14743396;15229132;15526285;16676351;18247329;22673903", "class_list": "", "function": "RFX2 and NF-Y binding to the testis-specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes, [RefSeq, PubMed]; These data support the hypothesis that RFX2 expression is upregulated in spermatocytes where it participates in activating transcription of the H1t gene and other testis genes., [RefSeq, PubMed]; Transcription factor that acts as a key regulator of spermatogenesis (By similarity). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329). Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:14743396, PubMed:15526285, PubMed:16676351, PubMed:18247329)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007286 spermatid development;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "B2GV50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08623-1", "uniprot_id": [ { "id": "SQSTM_RAT", "url": "https://www.uniprot.org/uniprot/O08623", "type": "external" } ], "mass": 47681.0, "length": 439, "protein_name": "Sequestosome-1", "gene_name": "Sqstm1", "organism": "Rat", "refseq_name": "sequestosome-1 isoform 1", "refseq_ac": [ { "id": "NP_787037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787037", "type": "external" } ], "gene_names_uniprotkb": "Sqstm1; Zip", "gene_names_refseq": "Osi; Sqstm1; ZIP3; ZIP", "protein_names_uniprotkb": "Sequestosome-1; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Ubiquitin-binding protein p62", "protein_names_refseq": "PKC-zeta-interacting protein; oxidative stress induced; protein kinase C-zeta-interacting protein; sequestosome-1 isoform 1; ubiquitin-binding protein p62", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); distal myopathy with rimmed vacuoles (Disease Ontology:DOID:0081363); neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (Disease Ontology:DOID:0081364); Paget's disease of bone 3 (Disease Ontology:DOID:0081366); frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (Disease Ontology:DOID:0110068); hypertension (Disease Ontology:DOID:10763); glaucoma (Disease Ontology:DOID:1686); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:113894); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-5205685); (R-RNO-9020702); (R-RNO-9664873); (R-RNO-9755511)", "pathway_count": 8, "publication_count": 17, "publication_id_list": "10366737;10477520;11162503;11244088;11500922;11981755;12431995;15143057;15158159;15802564;16079148;19728111;22673903;34581931;37466855;38308640;9177193", "class_list": "", "function": "Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy., [RefSeq, PubMed]; MiR-361-5p promotes oxygen-glucose deprivation/re-oxygenation induced neuronal injury by negatively regulating SQSTM1 in vitro., [RefSeq, PubMed]; Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (By similarity). Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps (By similarity). SQSTM1 first mediates the assembly and removal of ubiquitinated proteins by undergoing liquid-liquid phase separation upon binding to ubiquitinated proteins via its UBA domain, leading to the formation of insoluble cytoplasmic inclusions, known as p62 bodies (By similarity). SQSTM1 then interacts with ATG8 family proteins on autophagosomes via its LIR motif, leading to p62 body recruitment to autophagosomes, followed by autophagic clearance of ubiquitinated proteins (By similarity). SQSTM1 is itself degraded along with its ubiquitinated cargos (By similarity). Also required to recruit ubiquitinated proteins to PML bodies in the nucleus (By similarity). Also involved in autophagy of peroxisomes (pexophagy) in response to reactive oxygen species (ROS) by acting as a bridge between ubiquitinated PEX5 receptor and autophagosomes (By similarity). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex by sequestering the complex in inclusion bodies, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (By similarity). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (By similarity). Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). Sequesters tensin TNS2 into cytoplasmic puncta, promoting TNS2 ubiquitination and proteasomal degradation (By similarity). May regulate the activation of NFKB1 by TNF, nerve growth factor (NGF) and interleukin-1 (PubMed:11244088, PubMed:11500922). May play a role in titin/TTN downstream signaling in muscle cells (By similarity). Adapter that mediates the interaction between TRAF6 and CYLD (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; More potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2., [UniProtKB, PubMed]; The Relationship of p62 Gene Expression with Integrity of Mitochondrial DNA and the Level of Lipid Peroxidation Products in Skeletal Muscles of Rats of Different Ages Exposed to Different Feeding Protocols., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH59", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001659 temperature homeostasis;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08623-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES40-1", "uniprot_id": [ { "id": "PRAF3_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES40", "type": "external" } ], "mass": 21549.0, "length": 188, "protein_name": "PRA1 family protein 3", "gene_name": "Arl6ip5", "organism": "Rat", "refseq_name": "PRA1 family protein 3", "refseq_ac": [ { "id": "NP_076462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076462", "type": "external" } ], "gene_names_uniprotkb": "Arl6ip5; Gtrap3-18; Jwa; Pra2; Praf3", "gene_names_refseq": "Arl6ip5; Gtrap3-18", "protein_names_uniprotkb": "PRA1 family protein 3; ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; Prenylated Rab acceptor protein 2; Protein JWa", "protein_names_refseq": "ADP-ribosylation factor like GTPase 6 interacting protein 5; ADP-ribosylation factor-like 6 interacting protein 5; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; PRA1 family protein 3; aip-5; glutamate transporter EAAC1-interacting protein; prenylated Rab acceptor protein 2; protein JWa", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:66028); (R-RNO-210500)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11096102;11242046;14751295;19720795;21600884", "class_list": "", "function": "Regulates intracellular concentrations of taurine and glutamate (Ref.5). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner (PubMed:11242046). Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum (PubMed:19720795)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; The expression and distribution of the neuronal glutamate transporter, excitatory amino acid carrier-1 (EAAC1), are demonstrated in the dorsal root ganglion neurons and their central terminals., [RefSeq, PubMed]; These observations suggest that JWA is directly involved in the regulation of chronic morphine dependence., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKD1", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0002037 negative regulation of L-glutamate import across plasma membrane;GO:0007611 learning or memory;GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ES40-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYF1-1", "uniprot_id": [ { "id": "PPR37_RAT", "url": "https://www.uniprot.org/uniprot/B2RYF1", "type": "external" } ], "mass": 76934.0, "length": 710, "protein_name": "Protein phosphatase 1 regulatory subunit 37", "gene_name": "Ppp1r37", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 37", "refseq_ac": [ { "id": "NP_001100952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100952", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r37; Lrrc68", "gene_names_refseq": "Lrrc68; Ppp1r37", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 37; Leucine-rich repeat-containing protein 68", "protein_names_refseq": "leucine rich repeat containing 68; leucine-rich repeat-containing protein 68; protein phosphatase 1 regulatory subunit 37", "tax_id": 10116, "disease": "", "pathway": " (rno:308398)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RYF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58405-1", "uniprot_id": [ { "id": "STRN3_RAT", "url": "https://www.uniprot.org/uniprot/P58405", "type": "external" } ], "mass": 87111.0, "length": 794, "protein_name": "Striatin-3", "gene_name": "Strn3", "organism": "Rat", "refseq_name": "striatin-3", "refseq_ac": [ { "id": "NP_001025068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025068", "type": "external" } ], "gene_names_uniprotkb": "Strn3; Gs2na; Sg2na", "gene_names_refseq": "Gs2na; Sg2na; Strn3", "protein_names_uniprotkb": "Striatin-3; Cell cycle autoantigen SG2NA; S/G2 antigen", "protein_names_refseq": "cell cycle autoantigen SG2NA; nuclear autoantigen; s/G2 antigen; striatin, calmodulin binding protein 3; striatin-3-gamma; striatin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:114520)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18434427;22673903;37165139", "class_list": "", "function": "A rat STRN3 gamma-protein phosphatase 2A complex is recruited to agonist-activated estrogen receptor alpha, thereby leading to its dephosphorylation and inhibiting transcription., [RefSeq, PubMed]; Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress. Review article Erratum:[Cell Mol Neurobiol. 2023 Oct;43(7):3081. doi: 10.1007/s10571-023-01369-x. PMID: 37278863], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044877 protein-containing complex binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0032355 response to estradiol;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58405-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62773-1", "uniprot_id": [ { "id": "S28A2_RAT", "url": "https://www.uniprot.org/uniprot/Q62773", "type": "external" } ], "mass": 72615.0, "length": 659, "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "Slc28a2", "organism": "Rat", "refseq_name": "sodium/nucleoside cotransporter 2", "refseq_ac": [ { "id": "NP_113852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113852", "type": "external" } ], "gene_names_uniprotkb": "Slc28a2; Cnt2; Spnt", "gene_names_refseq": "Slc28a2", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter 2; CNT 2; Concentrative nucleoside transporter 2; Na(+)/nucleoside cotransporter 2; SPNT; Sodium-coupled nucleoside transporter 2; Sodium/purine nucleoside cotransporter; Solute carrier family 28 member 2; rCNT2", "protein_names_refseq": "CNT 2; Na(+)/nucleoside cotransporter 2; SPNT; concentrative nucleoside transporter 2; rCNT2; sodium-coupled nucleoside transporter 2; sodium/nucleoside cotransporter 2-like; sodium/nucleoside cotransporter 2; sodium/purine nucleoside cotransporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60423); (R-RNO-83936); (R-RNO-9748787); (R-RNO-9755088)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "12636174;1315767;22136384;22354287;22673903;23819782;25315414;28322028;29393594;7775409;8967974", "class_list": "", "function": "CNT2 is likely to modulate extracellular adenosine and cell energy balance in neuronal tissue., [RefSeq, PubMed]; RCNT2 extracellular cysteines, Cys(615) and Cys(649), are important for maturation and sorting to the plasma membrane, [RefSeq, PubMed]; Report induction of CNT2 in experimental diabetes mellitus., [RefSeq, PubMed]; Sodium-dependent and purine-selective (PubMed:1315767, PubMed:7775409, PubMed:8967974). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:1315767, PubMed:7775409, PubMed:8967974). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine (PubMed:7775409). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; The N-terminal tail of rCNT2 contains dual sorting signals. An acidic region is responsible for its proper stabilization at the plasma membrane, whereas the putative CK2 domain (Ser(46)) is implicated in the apical sorting of the transporter., [RefSeq, PubMed]; The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWI3", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity;GO:0005345 purine nucleobase transmembrane transporter activity;GO:0005337 nucleoside transmembrane transporter activity", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005886 plasma membrane;GO:0031526 brush border membrane;GO:0012506 vesicle membrane;GO:0016327 apicolateral plasma membrane", "go_biological_process": "GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport;GO:0001895 retina homeostasis;GO:0034394 protein localization to cell surface;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62773-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63425-1", "uniprot_id": [ { "id": "PRAX_RAT", "url": "https://www.uniprot.org/uniprot/Q63425", "type": "external" } ], "mass": 146400.0, "length": 1383, "protein_name": "Periaxin", "gene_name": "Prx", "organism": "Rat", "refseq_name": "periaxin", "refseq_ac": [ { "id": "NP_076466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076466", "type": "external" } ], "gene_names_uniprotkb": "Prx", "gene_names_refseq": "Prx", "protein_names_uniprotkb": "Periaxin", "protein_names_refseq": "periaxin", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 4F (Disease Ontology:DOID:0110193)", "pathway": " (rno:78960)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10671475;11430802;12591166;22673903;26467811;27629714;31931020;8155317;9488714", "class_list": "", "function": "Ezrin interacts with L-periaxin by the ''head to head and tail to tail'' mode and influences the location of L-periaxin in Schwann cell RSC96., [RefSeq, PubMed]; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology., [UniProtKB, UniProtKB]; The two periaxin isoforms interacted in the cytoplasm through the PDZ domain, and their interaction prevented the homodimerization of L-periaxin. S-periaxin may regulate the function of L-periaxin in Schwann cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0019233 sensory perception of pain;GO:0019226 transmission of nerve impulse;GO:0032287 peripheral nervous system myelin maintenance;GO:0043484 regulation of RNA splicing;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q63425-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47973-1", "uniprot_id": [ { "id": "TTP_RAT", "url": "https://www.uniprot.org/uniprot/P47973", "type": "external" } ], "mass": 33654.0, "length": 320, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "Zfp36", "organism": "Rat", "refseq_name": "mRNA decay activator protein ZFP36", "refseq_ac": [ { "id": "NP_579824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579824", "type": "external" } ], "gene_names_uniprotkb": "Zfp36; Tis11; Ttp", "gene_names_refseq": "Tis11; Zfp36", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; Zfp-36; Zinc finger protein 36", "protein_names_refseq": "TPA-induced sequence 11; TTP; mRNA decay activator protein ZFP36; tristetraproline; tristetraprolin; zfp-36", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:79426); (R-RNO-450513)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11129950;12054509;1511903;27193233", "class_list": "", "function": "Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:27193233). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Also functions by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:27193233). Also binds to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF) production by stimulating ARE-mediated TNF mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Also associates with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q54AH1", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0050779 RNA destabilization;GO:0032703 negative regulation of interleukin-2 production;GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:1902172 regulation of keratinocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P47973-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63384-1", "uniprot_id": [ { "id": "NTR2_RAT", "url": "https://www.uniprot.org/uniprot/Q63384", "type": "external" } ], "mass": 46266.0, "length": 416, "protein_name": "Neurotensin receptor type 2", "gene_name": "Ntsr2", "organism": "Rat", "refseq_name": "neurotensin receptor type 2", "refseq_ac": [ { "id": "NP_073186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073186", "type": "external" } ], "gene_names_uniprotkb": "Ntsr2; Ntr2", "gene_names_refseq": "Ntsr2", "protein_names_uniprotkb": "Neurotensin receptor type 2; High-affinity levocabastine-sensitive neurotensin receptor; NT-R-2; NTR2", "protein_names_refseq": "NT-R-2; NTR2 receptor; high-affinity levocabastine-sensitive neurotensin receptor; neurotensin receptor type 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64636); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12084713;12746866;15361549;17188644;17664042;22673903;28089664;32623746;8647296", "class_list": "", "function": "Expression and function of NTR2 receptors in rat cerebellar granule cells, [RefSeq, PubMed]; Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus., [RefSeq, PubMed]; NTS1/NTS2 heterodimerization affects the intracellular distribution and trafficking of NTS1 by making it more similar to that of NTS2 as witnessed in cells expressing NTS2 alone., [RefSeq, PubMed]; NTS2 is a bona fide NT receptor and that activation of this receptor by NT or NT analogs results in an internalization-dependent activation of the ERK1/2 signaling cascade., [RefSeq, PubMed]; Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; Study suggests that NTS1 and NTS2 neurotensin receptor mechanisms appear involved in fear conditioning processes and that agonists for neurotensin receptors may be pursued as novel anxiolytic drugs., [RefSeq, PubMed]; The distribution of NTS2-like immunoreactivity largely exceeded that of neurotensin terminal fields, and some of the highest concentrations of the receptor were found in areas devoid of neurotensinergic inputs., [RefSeq, PubMed]; These results also provide evidence that activation of NTR1 in the RVM produces antinociception through spinal release of norepinephrine (NE) and serotonin, and that activation of NTR2 in the RVM produces antinociception mediated by spinal release of NE., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016492 G protein-coupled neurotensin receptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043198 dendritic shaft;GO:0043204 perikaryon", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0042391 regulation of membrane potential;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63384-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35394-1", "uniprot_id": [ { "id": "PRAF1_RAT", "url": "https://www.uniprot.org/uniprot/O35394", "type": "external" } ], "mass": 20643.0, "length": 185, "protein_name": "Prenylated Rab acceptor protein 1", "gene_name": "Rabac1", "organism": "Rat", "refseq_name": "prenylated Rab acceptor protein 1", "refseq_ac": [ { "id": "NP_113962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113962", "type": "external" } ], "gene_names_uniprotkb": "Rabac1; Pra1; Praf1", "gene_names_refseq": "Pra1; Rabac1", "protein_names_uniprotkb": "Prenylated Rab acceptor protein 1; PRA1 family protein 1", "protein_names_refseq": "PRA1 family protein 1; Rab acceptor 1 (prenylated); prenylated Rab acceptor protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83583)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10707984;10751420;11096102;12107180;9341137", "class_list": "", "function": "General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0070064 proline-rich region binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35394-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08635-1", "uniprot_id": [ { "id": "SAST_RAT", "url": "https://www.uniprot.org/uniprot/P08635", "type": "external" } ], "mass": 29471.0, "length": 263, "protein_name": "S-acyl fatty acid synthase thioesterase, medium chain", "gene_name": "Olah", "organism": "Rat", "refseq_name": "S-acyl fatty acid synthase thioesterase, medium chain", "refseq_ac": [ { "id": "NP_073196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073196", "type": "external" } ], "gene_names_uniprotkb": "Olah; Mch; Thedc1", "gene_names_refseq": "Mch; Olah; Thedc1", "protein_names_uniprotkb": "S-acyl fatty acid synthase thioesterase, medium chain; 3.1.2.14; Medium-chain S-acyl fatty acid synthetase thioester hydrolase; Oleoyl-ACP hydrolase; Thioesterase II; Thioesterase domain-containing protein 1", "protein_names_refseq": "S-acyl fatty acid synthase thioesterase, medium chain; medium-chain S-acyl fatty acid synthetase thio ester hydrolase (MCH); medium-chain S-acyl fatty acid synthetase thioester hydrolase; thioesterase II; thioesterase domain containing 1; thioesterase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64669)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15905320;3104035;3105579;3567174;3632637;8446599", "class_list": "", "function": "Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Sex differences in the response of MCH neurons to glucose correlated well with the gonadal steroid milieu., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0016297 fatty acyl-[ACP] hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008610 lipid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08635-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09811-1", "uniprot_id": [ { "id": "PYGL_RAT", "url": "https://www.uniprot.org/uniprot/P09811", "type": "external" } ], "mass": 97483.0, "length": 850, "protein_name": "Glycogen phosphorylase, liver form", "gene_name": "Pygl", "organism": "Rat", "refseq_name": "glycogen phosphorylase, liver form", "refseq_ac": [ { "id": "NP_071604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071604", "type": "external" } ], "gene_names_uniprotkb": "Pygl; Lgp", "gene_names_refseq": "Pygl", "protein_names_uniprotkb": "Glycogen phosphorylase, liver form; 2.4.1.1", "protein_names_refseq": "glycogen phosphorylase, liver form; liver glycogen phosphorylase; phosphorylase, glycogen, liver", "tax_id": 10116, "disease": "glycogen storage disease (Disease Ontology:DOID:2747); glycogen storage disease VI (Disease Ontology:DOID:2754); lactic acidosis (Disease Ontology:DOID:3650)", "pathway": " (rno:64035); (R-RNO-6798695); (R-RNO-70221)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1339293;1765272;22673903;2424788;25336395;2575583;7498521;7720853;8482535;9841883", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that two biomarkers, glycine N-methyltransferase (GNMT) and glycogen phosphorylase (PYGL), were found to indicate early hepatic injuries., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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{ "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { 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"id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0009617 response to bacterium;GO:0042593 glucose homeostasis;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0070266 necroptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09811-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0A2-1", "uniprot_id": [ { "id": "VPS36_RAT", "url": "https://www.uniprot.org/uniprot/P0C0A2", "type": "external" } ], "mass": 43718.0, "length": 386, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "Vps36", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vps36; Eap45", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36", "protein_names_refseq": "", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (R-RNO-917729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11278625", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C0A2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6T3-1", "uniprot_id": [ { "id": "PRR7_RAT", "url": "https://www.uniprot.org/uniprot/P0C6T3", "type": "external" } ], "mass": 30377.0, "length": 269, "protein_name": "Proline-rich protein 7", "gene_name": "Prr7", "organism": "Rat", "refseq_name": "proline-rich protein 7", "refseq_ac": [ { "id": "NP_001102586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102586", "type": "external" } ], "gene_names_uniprotkb": "Prr7", "gene_names_refseq": "Prr7", "protein_names_uniprotkb": "Proline-rich protein 7; Synaptic proline-rich membrane protein", "protein_names_refseq": "proline-rich protein 7; synaptic proline-rich membrane protein", "tax_id": 10116, "disease": "", "pathway": " (rno:498704)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15629447;27458189;36150742", "class_list": "", "function": "Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (By similarity). Might promote apoptosis in T cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; MiR-329- and miR-495-mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons. Publication Status: Online-Only, [RefSeq, PubMed]; PRR7 is involved in modulating neural activities via interactions with the NMDA receptor and postsynaptic density (PSD)-95, and PSD core formation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0044877 protein-containing complex binding;GO:0044389 ubiquitin-like protein ligase binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0002250 adaptive immune response;GO:0030217 T cell differentiation;GO:0006356 regulation of transcription by RNA polymerase I;GO:0099527 postsynapse to nucleus signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C6T3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12346-1", "uniprot_id": [ { "id": "TRFE_RAT", "url": "https://www.uniprot.org/uniprot/P12346", "type": "external" } ], "mass": 76395.0, "length": 698, "protein_name": "Serotransferrin", "gene_name": "Tf", "organism": "Rat", "refseq_name": "serotransferrin precursor", "refseq_ac": [ { "id": "NP_001013128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013128", "type": "external" } ], "gene_names_uniprotkb": "Tf", "gene_names_refseq": "Tfn; Tf; Trf", "protein_names_uniprotkb": "Serotransferrin; Beta-1 metal-binding globulin; Liver regeneration-related protein LRRG03; Siderophilin; Transferrin", "protein_names_refseq": "beta-1 metal-binding globulin; liver regeneration-related protein LRRG03; serotransferrin precursor; serotransferrin; siderophilin", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); atransferrinemia (Disease Ontology:DOID:0050649); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); iron deficiency anemia (Disease Ontology:DOID:11758); hepatitis (Disease Ontology:DOID:2237); anemia (Disease Ontology:DOID:2355); glomerulonephritis (Disease Ontology:DOID:2921); hyperglycemia (Disease Ontology:DOID:4195); gastrointestinal system disease (Disease Ontology:DOID:77); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24825); (R-RNO-114608); (R-RNO-381426); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8957275); (R-RNO-917937); (R-RNO-917977)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "10.1039/D0MO00044B;15047867;1791188;1997323;21454685;24090084;29248829;3023031;3046665;30758712;34106099;36361544;500689;6236811;7717992;8829802", "class_list": "", "function": "Neuroprotective Effects of Transferrin in Experimental Glaucoma Models. Publication Status: Online-Only, [RefSeq, PubMed]; Our data establish that blood TSAT exerts a critical role in experimental stroke-induced brain damage. In addition, our findings suggest that the protective effect of iron-free transferrin (apotransferrin, ATf) at the neuronal level resides in preventing NMDA-induced HTf uptake and ROS production, which in turn reduces neuronal damage, [RefSeq, PubMed]; Tf can be incorporated by all glial cells-i.e., microglia, astrocytes, and oligodendroglial precursor cell-and that, acting on microglial cells in vitro, Tf increases microglial proliferation rates and phagocytic capacity., [RefSeq, PubMed]; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 8, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 15, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63602;Q64628;Q64630;Q7TNX0", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0044325 transmembrane transporter binding;GO:0008198 ferrous iron binding;GO:0034986 iron chaperone activity;GO:1990459 transferrin receptor binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007166 cell surface receptor signaling pathway;GO:0010288 response to lead ion;GO:0019731 antibacterial humoral response;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P12346-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14646-3", "uniprot_id": [ { "id": "PDE4B_RAT", "url": "https://www.uniprot.org/uniprot/P14646", "type": "external" } ], "mass": 83375.0, "length": 736, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4B", "gene_name": "Pde4b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pde4b", "gene_names_refseq": "", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4B; 3.1.4.53; DPDE4; cAMP-specific phosphodiesterase 4B", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:24626); (R-RNO-180024)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12441002;1655746;19103603;22673903;2542941;2546153;7958996;8276818;9371714", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKL0;Q8VD81;Q8VD82", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0043015 gamma-tubulin binding;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043197 dendritic spine", "go_biological_process": "GO:1901898 negative regulation of relaxation of cardiac muscle;GO:0050852 T cell receptor signaling pathway;GO:0071466 cellular response to xenobiotic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0071878 negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14646-3", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17431-1", "uniprot_id": [ { "id": "TISB_RAT", "url": "https://www.uniprot.org/uniprot/P17431", "type": "external" } ], "mass": 36399.0, "length": 338, "protein_name": "mRNA decay activator protein ZFP36L1", "gene_name": "Zfp36l1", "organism": "Rat", "refseq_name": "mRNA decay activator protein ZFP36L1", "refseq_ac": [ { "id": "NP_058868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058868", "type": "external" } ], "gene_names_uniprotkb": "Zfp36l1; Brf1; Cmg1; Tis11b", "gene_names_refseq": "Berg36; Brf1; ERF1; TIS11b; Zfp36l1; cMG1", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36L1; Butyrate response factor 1; EGF-inducible protein CMG1; TPA-induced sequence 11b; ZFP36-like 1; Zinc finger protein 36, C3H1 type-like 1", "protein_names_refseq": "EGF-inducible protein CMG1; TPA-induced sequence 11b; ZFP36-like 1; butyrate response factor 1; mRNA decay activator protein ZFP36L1; zinc finger protein 36, C3H1 type-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29344); (R-RNO-450385)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10751406;11279239;12748283;15538381;1695727;38653384;7575462", "class_list": "", "function": "ZFP36L1 controls KLF16 mRNA stability in vascular smooth muscle cells during restenosis after vascular injury., [RefSeq, PubMed]; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406, PubMed:12748283). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:12748283). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:12748283). Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:11279239). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:10751406). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress. Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA. Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation. May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA. In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation. Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. Participates in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in vasculogenesis and endocardial development. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role in myoblast cell differentiation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LAU8", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0071889 14-3-3 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0003342 proepicardium development;GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:0097403 cellular response to raffinose;GO:1902172 regulation of keratinocyte apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P17431-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31647-1", "uniprot_id": [ { "id": "S6A11_RAT", "url": "https://www.uniprot.org/uniprot/P31647", "type": "external" } ], "mass": 69947.0, "length": 627, "protein_name": "Sodium- and chloride-dependent GABA transporter 3", "gene_name": "Slc6a11", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent GABA transporter 3", "refseq_ac": [ { "id": "NP_077348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077348", "type": "external" } ], "gene_names_uniprotkb": "Slc6a11; Gabt3; Gat-3; Gat-b", "gene_names_refseq": "Gabt4; Gat3; Slc6a11", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 11", "protein_names_refseq": "GABA transporter GAT-3; GAT-3; sodium- and chloride-dependent GABA transporter 3; solute carrier family 6 (neurotransmitter transporter), member 11; solute carrier family 6 (neurotransmitter transporter, GABA), member 11", "tax_id": 10116, "disease": "", "pathway": " (rno:79213); (R-RNO-442660); (R-RNO-71288); (R-RNO-888593)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12107427;1400419;1497897;22673903;27886179;29742425;29930131;38843836;8731228", "class_list": "", "function": "A small proportion of inhibitory motor neurons and at least some putative intrinsic primary afferent neurons within the rat gastrointestinal tract express GAT3., [RefSeq, PubMed]; Expression of the gamma-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol., [RefSeq, PubMed]; Glial GAT-3 transporters are downregulated while neuronal GAT-1 function remains normal in dopamine-depleted rodents., [RefSeq, PubMed]; Increases in GAT-3 activity result in astrocytic Na+ accumulation and a consequent increase in astrocytic Ca2+ through Na+/Ca2+ exchange, leading to the astrocytic release of ATP/adenosine. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:1400419, PubMed:1497897). Can also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0016597 amino acid binding;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus;GO:0001504 neurotransmitter uptake;GO:0015718 monocarboxylic acid transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P31647-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38652-1", "uniprot_id": [ { "id": "PGM1_RAT", "url": "https://www.uniprot.org/uniprot/P38652", "type": "external" } ], "mass": 61403.0, "length": 562, "protein_name": "Phosphoglucomutase-1", "gene_name": "Pgm1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pgm1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoglucomutase-1; 5.4.2.2; Glucose phosphomutase 1; PGM 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570); endometrial cancer (Disease Ontology:DOID:1380); teratoma (Disease Ontology:DOID:3307)", "pathway": " (rno:24645); (R-RNO-3322077); (R-RNO-6798695); (R-RNO-70221); (R-RNO-70370)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;8224913", "class_list": "", "function": "Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:8224913). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable). This enzyme participates in both the breakdown and synthesis of glucose (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030018 Z disc;GO:0005737 cytoplasm", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006874 intracellular calcium ion homeostasis;GO:0006006 glucose metabolic process;GO:0071259 cellular response to magnetism;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P38652-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58775-1", "uniprot_id": [ { "id": "TPM2_RAT", "url": "https://www.uniprot.org/uniprot/P58775", "type": "external" } ], "mass": 32837.0, "length": 284, "protein_name": "Tropomyosin beta chain", "gene_name": "Tpm2", "organism": "Rat", "refseq_name": "tropomyosin beta chain isoform Tpm2.1sm/cy", "refseq_ac": [ { "id": "NP_001019516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019516", "type": "external" } ], "gene_names_uniprotkb": "Tpm2", "gene_names_refseq": "Tpm2", "protein_names_uniprotkb": "Tropomyosin beta chain; Beta-tropomyosin; Tropomyosin-2", "protein_names_refseq": "beta-tropomyosin; tropomyosin 2, beta; tropomyosin beta chain isoform Tpm2.1sm/cy; tropomyosin beta chain", "tax_id": 10116, "disease": "congenital myopathy 23 (Disease Ontology:DOID:0110932); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:500450); (R-RNO-390522); (R-RNO-445355)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22673903;22812662;23110217;2432392;29183317;3840484;7568216", "class_list": "", "function": "Binds to actin filaments in muscle and non-muscle cells (PubMed:22812662, PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; This study identified a novel role of Smad4 SUMOylation and TPM2 in learning and memory formation. These results suggest that patients with skeletal myopathies who carry the TPM2E122K mutation may also have deficits in learning and memory functions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02560;P06395", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0043462 regulation of ATP-dependent activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P58775-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70617-1", "uniprot_id": [ { "id": "NINJ1_RAT", "url": "https://www.uniprot.org/uniprot/P70617", "type": "external" } ], "mass": 16539.0, "length": 152, "protein_name": "Ninjurin-1", "gene_name": "Ninj1", "organism": "Rat", "refseq_name": "ninjurin-1", "refseq_ac": [ { "id": "NP_036999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036999", "type": "external" } ], "gene_names_uniprotkb": "Ninj1", "gene_names_refseq": "Ninj1", "protein_names_uniprotkb": "Ninjurin-1; Nerve injury-induced protein 1", "protein_names_refseq": "nerve injury-induced protein 1; ninjurin-1", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); mandibulofacial dysostosis with alopecia (Disease Ontology:DOID:0060365); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184); velocardiofacial syndrome (Disease Ontology:DOID:12583); impotence (Disease Ontology:DOID:1875); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); lung disease (Disease Ontology:DOID:850); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:25338)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19595672;22673903;33028854;8780658", "class_list": "", "function": "Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis) (By similarity). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell (By similarity). Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane (By similarity). Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively (By similarity). Acts as an effector of PANoptosis downstream of CASP1, CASP4, CASP8 and RIPK3 (By similarity). Also induces plasma membrane rupture in response to cell swelling caused by osmotic stress and ferroptosis downstream of lipid peroxidation (By similarity). Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS (By similarity). Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding (By similarity). Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in various processes such as axonal growth, cell chemotaxis and angiogenesis (By similarity). Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM) (PubMed:19595672). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells (By similarity). Plays a role in nerve regeneration by promoting maturation of Schwann cells (By similarity). Acts as a regulator of angiogenesis (PubMed:33028854). Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells (By similarity). Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts (By similarity). Also involved in striated muscle growth and differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Ninj1 may mediate the entry of myeloid cells into the CNS in normal and EAE brains, and it is a potential therapeutic target for regulating myeloid cell trafficking across the blood-brain barrier in CNS immune processes., [RefSeq, PubMed]; Secreted form generated by cleavage, which has chemotactic activity. Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0098632 cell-cell adhesion mediator activity;GO:0098631 cell adhesion mediator activity;GO:0140912 membrane destabilizing activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0031527 filopodium membrane;GO:0097060 synaptic membrane", "go_biological_process": "GO:2001206 positive regulation of osteoclast development;GO:1990384 hyaloid vascular plexus regression;GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70617-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05982-1", "uniprot_id": [ { "id": "NDKA_RAT", "url": "https://www.uniprot.org/uniprot/Q05982", "type": "external" } ], "mass": 17193.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "Nme1", "organism": "Rat", "refseq_name": "nucleoside diphosphate kinase A", "refseq_ac": [ { "id": "NP_612557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612557", "type": "external" } ], "gene_names_uniprotkb": "Nme1", "gene_names_refseq": "GAAD; NDK1; NDPK A; NM23-H1; Nme1", "protein_names_uniprotkb": "Nucleoside diphosphate kinase A; 2.7.11.1; 2.7.13.3; 2.7.4.18; 2.7.4.6; 3.1.11.-; 3.1.24.-; Farnesyl diphosphate kinase NME1; GAAD; Histidine protein kinase NME1; Metastasis inhibition factor NM23; NDK1; NDP kinase A; NDPK A; NM23-H1; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease; Tumor metastatic process-associated protein", "protein_names_refseq": "NDK A; NDP kinase A; NDP kinase beta; expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase); farnesyl diphosphate kinase NME1; histidine protein kinase NME1; metastasis inhibition factor NM23; non-metastatic cells 1, protein (NM23A) expressed in; non-specific serine/threonine protein kinase NME1; nucleoside diphoshate kinase 1; nucleoside diphosphate kinase A; nucloside diphosphate kinase; putative 3'-5'-DNA exonuclease NDK1; putative granzyme A-activated DNA endonuclease; tumor metastatic process-associated protein", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); teratoma (Disease Ontology:DOID:3307); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); renal cell carcinoma (Disease Ontology:DOID:4450); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (rno:191575); (R-RNO-499943); (R-RNO-9748787); (R-RNO-9755088)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10952986;24395206;33903070;7665595;8381409", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:7665595). Also phosphorylates geranyl pyrophosphate (GPP) and farnesyl pyrophosphate (FPP), linking it to isoprenoid metabolism (PubMed:10952986). Additionally, functions as a non-specific serine/threonine kinase and histidine protein kinase, transferring phosphoryl groups from its active site to target proteins (PubMed:7665595). May function as a Mg(2+)-dependent single-stranded DNA endonuclease as part of the SET complex, cooperating with the 3'-5' exonuclease TREX1 to mediate apoptotic DNA fragmentation in cytotoxic T lymphocytes. Reported to nick one DNA strand, enabling TREX1 to remove nucleotides from the free 3' end, enhancing DNA damage and suppressing DNA end reannealing and repair. Has been shown to cleave double strands DNA within the 3'-portions of both 5'-SHS silencer and NHE basal promoter element of the PDGFA gene, potentially repressing its transcription. May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (By similarity). Involved in the regulation of tumor metastasis and cellular differentiation (By similarity). Also required for cell motility (By similarity). May control, with NME2, AcCoA usage between histone acetylation and fatty acid synthesis, possibly by binding and releasing AcCoA at transcriptionally active chromatin regions in proximity to histone acetyltransferase (HAT) (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; NDPKA up-regulation increased neuronal survival in cortical neurons from cerebral ischemia models., [RefSeq, PubMed]; Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome;GO:0005813 centrosome", "go_biological_process": "GO:0006897 endocytosis;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05982-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRD0-1", "uniprot_id": [ { "id": "SYDM_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRD0", "type": "external" } ], "mass": 73953.0, "length": 652, "protein_name": "Aspartate--tRNA ligase, mitochondrial", "gene_name": "Dars2", "organism": "Rat", "refseq_name": "aspartate--tRNA ligase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001029315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029315", "type": "external" } ], "gene_names_uniprotkb": "Dars2", "gene_names_refseq": "Dars2; RGD1308286", "protein_names_uniprotkb": "Aspartate--tRNA ligase, mitochondrial; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspRS; aspartate--tRNA ligase, mitochondrial isoform 1; aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase, mitochondrial", "tax_id": 10116, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (rno:304919)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0050560 aspartate-tRNA(Asn) ligase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation;GO:0006422 aspartyl-tRNA aminoacylation;GO:0043039 tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KRD0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q496Z2-1", "uniprot_id": [ { "id": "TRIL_RAT", "url": "https://www.uniprot.org/uniprot/Q496Z2", "type": "external" } ], "mass": 89053.0, "length": 811, "protein_name": "TLR4 interactor with leucine rich repeats", "gene_name": "Tril", "organism": "Rat", "refseq_name": "TLR4 interactor with leucine rich repeats precursor", "refseq_ac": [ { "id": "NP_001029182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029182", "type": "external" } ], "gene_names_uniprotkb": "Tril", "gene_names_refseq": "RGD1310827; Tril", "protein_names_uniprotkb": "TLR4 interactor with leucine rich repeats; Leucine-rich repeat-containing protein KIAA0644 homolog", "protein_names_refseq": "TLR4 interactor with leucine rich repeats precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:362364)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19710467;22673903", "class_list": "", "function": "Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion and the inflammatory response (By similarity)., [UniProtKB]; Reports data for human and mouse TRIL, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0046696 lipopolysaccharide receptor complex", "go_biological_process": "GO:0002718 regulation of cytokine production involved in immune response;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0034142 toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q496Z2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM74-1", "uniprot_id": [ { "id": "SC22B_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM74", "type": "external" } ], "mass": 24741.0, "length": 215, "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "Sec22b", "organism": "Rat", "refseq_name": "vesicle-trafficking protein SEC22b", "refseq_ac": [ { "id": "NP_001020857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020857", "type": "external" } ], "gene_names_uniprotkb": "Sec22b; Sec22l1", "gene_names_refseq": "Sec22b; Sec22l1", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22b; ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1", "protein_names_refseq": "ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1; vesicle-trafficking protein SEC22b", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:310710)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10930465;11035026;14742712;22673903;33186631", "class_list": "", "function": "SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, PubMed, PubMed, UniProtKB]; Upregulation of Sec22b plays a neuroprotective role in a rat model of traumatic brain injury via inducing protective autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0016192 vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q4KM74-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK82-1", "uniprot_id": [ { "id": "TRI69_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK82", "type": "external" } ], "mass": 57215.0, "length": 499, "protein_name": "E3 ubiquitin-protein ligase TRIM69", "gene_name": "Trim69", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM69", "refseq_ac": [ { "id": "NP_001013178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013178", "type": "external" } ], "gene_names_uniprotkb": "Trim69; Rnf36", "gene_names_refseq": "Rnf36; Trim69", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM69; 2.3.2.27; RING finger protein 36; RING-type E3 ubiquitin transferase TRIM69; Tripartite motif-containing protein 69", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM69; RING-type E3 ubiquitin transferase TRIM69; ring finger protein 36; tripartite motif-containing protein 69", "tax_id": 10116, "disease": "", "pathway": " (rno:311373); (R-RNO-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination;GO:0071539 protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BK82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H28-1", "uniprot_id": [ { "id": "PACC1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H28", "type": "external" } ], "mass": 40073.0, "length": 350, "protein_name": "Proton-activated chloride channel", "gene_name": "Pacc1", "organism": "Rat", "refseq_name": "proton-activated chloride channel", "refseq_ac": [ { "id": "NP_001007680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007680", "type": "external" } ], "gene_names_uniprotkb": "Pacc1; Tmem206", "gene_names_refseq": "PAC; Pacc1; RGD1359339; Tmem206", "protein_names_uniprotkb": "Proton-activated chloride channel; PAC; Transmembrane protein 206", "protein_names_refseq": "proton-activated chloride channel; transmembrane protein 206", "tax_id": 10116, "disease": "", "pathway": " (rno:305070)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0061797 pH-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66H28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY7-1", "uniprot_id": [ { "id": "PR38B_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY7", "type": "external" } ], "mass": 63932.0, "length": 542, "protein_name": "Pre-mRNA-splicing factor 38B", "gene_name": "Prpf38b", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor 38B", "refseq_ac": [ { "id": "NP_001019476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019476", "type": "external" } ], "gene_names_uniprotkb": "Prpf38b", "gene_names_refseq": "Prpf38b", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 38B", "protein_names_refseq": "PRP38 pre-mRNA processing factor 38 domain containing B; pre-mRNA-splicing factor 38B", "tax_id": 10116, "disease": "", "pathway": " (rno:499691)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May be required for pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0071011 precatalytic spliceosome;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75N33-1", "uniprot_id": [ { "id": "SC16B_RAT", "url": "https://www.uniprot.org/uniprot/Q75N33", "type": "external" } ], "mass": 116897.0, "length": 1057, "protein_name": "Protein transport protein Sec16B", "gene_name": "Sec16b", "organism": "Rat", "refseq_name": "protein transport protein Sec16B", "refseq_ac": [ { "id": "NP_446023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446023", "type": "external" } ], "gene_names_uniprotkb": "Sec16b; Lztr2; Rgpr", "gene_names_refseq": "Lztr2; Rgpr; Sec16b", "protein_names_uniprotkb": "Protein transport protein Sec16B; Leucine zipper transcription regulator 2; RGPR-p117; Regucalcin gene promoter region-related protein p117; SEC16 homolog B", "protein_names_refseq": "RGPR-p117; leucine zipper transcription regulator 2; protein SEC16 homolog B; protein transport protein Sec16B; regucalcin gene promoter region related protein; regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:89868); (R-RNO-204005)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11605020;12244571;12647292;16211248;16273285;16676356;17786289;22673903;35835253", "class_list": "", "function": "Determined expression of mRNA in liver with change in sex, age and fasting; did not directly bind to the regucalcin TTGGC motif, [RefSeq, PubMed]; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes., [UniProtKB, UniProtKB]; RGPR-p117 can enhance the regucalcin promoter activity which is related to the NF-1 consensus sequences including TTGGC motif, and its enhancing effect is partly mediated through phosphorylation and dephosphorylation, [RefSeq, PubMed]; RGPR-p117 is localized in the nucleus of kidney cells, and may be involved in gene expression., [RefSeq, PubMed]; The overexpressed transcription factor RGPR-p117 suppresses the proliferation of normal rat kidney proximal tubular epithelial NRK-52E cells: Involvement of diverse signaling pathways., [RefSeq, PubMed]; This study demonstrates that overexpression of RGPR-p117 enhances the expression of regucalcin mRNA and its protein level in NRK52E cells. RGPR-p117 may play a role as a transcriptional factor., [RefSeq, PubMed]; This study demonstrates that overexpression of RGPR-p117 has a suppressive effect on cell death and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q925T1", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0015031 protein transport;GO:0016559 peroxisome fission;GO:0007031 peroxisome organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q75N33-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZY8-1", "uniprot_id": [ { "id": "TRIM9_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZY8", "type": "external" } ], "mass": 79206.0, "length": 710, "protein_name": "E3 ubiquitin-protein ligase TRIM9", "gene_name": "Trim9", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM9 isoform 1", "refseq_ac": [ { "id": "NP_569104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569104", "type": "external" } ], "gene_names_uniprotkb": "Trim9; Spring", "gene_names_refseq": "Trim9", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM9; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM9; SNAP-25-interacting RING finger protein; Tripartite motif-containing protein 9", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM9 isoform 1; E3 ubiquitin-protein ligase TRIM9; RING-type E3 ubiquitin transferase TRIM9; SNAP-25-interacting RING finger protein; Spring; tripartite motif protein 9; tripartite motif-containing protein 9", "tax_id": 10116, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697)", "pathway": " (rno:155812); (R-RNO-983168)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11524423;20085810;22673903;37792226;38432885", "class_list": "", "function": "E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRIM9 promotes Muller cell-derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7., [RefSeq, PubMed]; Trim9 regulates the directional differentiation of retinal Muller cells to retinal ganglion cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0045202 synapse;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045955 negative regulation of calcium ion-dependent exocytosis;GO:0016567 protein ubiquitination;GO:0035544 negative regulation of SNARE complex assembly;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JID1-1", "uniprot_id": [ { "id": "PDCD4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JID1", "type": "external" } ], "mass": 51736.0, "length": 469, "protein_name": "Programmed cell death protein 4", "gene_name": "Pdcd4", "organism": "Rat", "refseq_name": "programmed cell death protein 4", "refseq_ac": [ { "id": "NP_071601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071601", "type": "external" } ], "gene_names_uniprotkb": "Pdcd4; Dug", "gene_names_refseq": "Dug; Pdcd4", "protein_names_uniprotkb": "Programmed cell death protein 4; Death up-regulated gene protein", "protein_names_refseq": "death up-regulated gene protein; death-upregulated; eIF4G-like protein; programmed cell death protein 4", "tax_id": 10116, "disease": "skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:64031)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12220511;15062553;16641100;22673903;33610591;33831322;34506261;35051553;37549728", "class_list": "", "function": "Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury., [RefSeq, PubMed]; Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling., [RefSeq, PubMed]; Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5., [RefSeq, PubMed]; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Pdcd4 promotes lipid deposition by attenuating PPARalpha-mediated fatty acid oxidation in hepatocytes., [RefSeq, PubMed]; Shear stress inhibits cardiac microvascular endothelial cells apoptosis to protect against myocardial ischemia reperfusion injury via YAP/miR-206/PDCD4 signaling pathway., [RefSeq, PubMed]; Transfected Pdcd4 suppresses carbonic anhydrase type II protein expression in HEK293 and Bon-1 carcinoid cells; the translation inhibitor pdcd4 represses endocrine tumor cell growth by suppression of carbonic anhydase II, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043279 response to alkaloid;GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:1904761 negative regulation of myofibroblast differentiation;GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JID1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64294-1", "uniprot_id": [ { "id": "PDPN_RAT", "url": "https://www.uniprot.org/uniprot/Q64294", "type": "external" } ], "mass": 17579.0, "length": 166, "protein_name": "Podoplanin", "gene_name": "Pdpn", "organism": "Rat", "refseq_name": "podoplanin isoform 1 precursor", "refseq_ac": [ { "id": "NP_062231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062231", "type": "external" } ], "gene_names_uniprotkb": "Pdpn", "gene_names_refseq": "E11; Gp38; OTS-8; Pdpn; RTI140; RTI40; T1-alpha; T1A", "protein_names_uniprotkb": "Podoplanin; E11 antigen epitope; RTI140; T1-alpha; T1A; Type I cell 40 kDa protein", "protein_names_refseq": "E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 38; podoplanin isoform 1 precursor; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; type I cell 40 kDa protein", "tax_id": 10116, "disease": "adult respiratory distress syndrome (Disease Ontology:DOID:11394); oligohydramnios (Disease Ontology:DOID:12215); nephrosis (Disease Ontology:DOID:2527); glioblastoma (Disease Ontology:DOID:3068); germinoma (Disease Ontology:DOID:3304); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); in situ carcinoma (Disease Ontology:DOID:8719); bacterial pneumonia (Disease Ontology:DOID:874)", "pathway": " (rno:54320); (R-RNO-114604)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "26064894;27039006;30088964;7851650;8833206;9327748;9761764;9920397", "class_list": "", "function": "Four genes are expressed significantly higher in basal bone than in alveolar bone: SOST, E-11, DMP-1, and MEPE. Three of the proteins (SOST, MEPE, and DMP-1) are associated with mature osteocytes, indicating that basal bone has more mature osteocyte phenotypes because the immature osteocyte converts to a mature osteocyte as a result of bone mineralization., [RefSeq, PubMed]; In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and alpha-smooth muscle actin at the surface of the peritoneum was observed, [RefSeq, PubMed]; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells (By similarity). In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 (By similarity). Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels (By similarity). Does not have any effect on folic acid or amino acid transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The binding epitope of PMab-2 remains to be determined. Herein, we investigated the epitope of PMab-2 using enzyme-linked immunosorbent assay, immunohistochemical analysis, and flow cytometry. The results revealed that the critical epitope of PMab-2 is Leu46 and Glu47 of rPDPN., [RefSeq, PubMed]", "predicted_glycosites": 18, "predicted_n_glycosites": 0, "predicted_o_glycosites": 18, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "O08731;O55210", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051087 protein-folding chaperone binding;GO:0019956 chemokine binding", "go_cellular_component": "GO:0061851 leading edge of lamellipodium;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0060838 lymphatic endothelial cell fate commitment;GO:1904328 regulation of myofibroblast contraction;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64294-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63495-1", "uniprot_id": [ { "id": "RAGE_RAT", "url": "https://www.uniprot.org/uniprot/Q63495", "type": "external" } ], "mass": 42664.0, "length": 402, "protein_name": "Advanced glycation end product-specific receptor", "gene_name": "Ager", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ager; Rage", "gene_names_refseq": "", "protein_names_uniprotkb": "Advanced glycation end product-specific receptor; Receptor for advanced glycation end products", "protein_names_refseq": "", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); chorioamnionitis (Disease Ontology:DOID:0050697); diabetic encephalopathy (Disease Ontology:DOID:0050850); renal fibrosis (Disease Ontology:DOID:0050855); stroke (Disease Ontology:DOID:0051061); chronic pancreatitis (Disease Ontology:DOID:0051065); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); colorectal carcinoma (Disease Ontology:DOID:0080199); mild cognitive impairment (Disease Ontology:DOID:0080832); prostate cancer (Disease Ontology:DOID:10283); schizotypal personality disorder (Disease Ontology:DOID:10646); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); adult respiratory distress syndrome (Disease Ontology:DOID:11394); osteoporosis (Disease Ontology:DOID:11476); morbid obesity (Disease Ontology:DOID:11981); diabetic polyneuropathy (Disease Ontology:DOID:12785); cardiovascular system disease (Disease Ontology:DOID:1287); thromboangiitis obliterans (Disease Ontology:DOID:12918); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Kawasaki disease (Disease Ontology:DOID:13378); aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); optic nerve disease (Disease Ontology:DOID:1891); melanoma (Disease Ontology:DOID:1909); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); Takayasu's arteritis (Disease Ontology:DOID:2508); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); uremia (Disease Ontology:DOID:4676); liver cirrhosis (Disease Ontology:DOID:5082); aortic disease (Disease Ontology:DOID:520); schizophrenia (Disease Ontology:DOID:5419); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); osteoarthritis (Disease Ontology:DOID:8398); Cor pulmonale (Disease Ontology:DOID:8515); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); vascular skin disease (Disease Ontology:DOID:9540); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-RNO-445989); (R-RNO-879415); (R-RNO-933542)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19910580;22673903;28627626;9224812", "class_list": "", "function": "Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, histones, phospholipids and glycosaminoglycans (PubMed:19910580, PubMed:28627626). Advanced glycation end products (AGEs) are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. These ligands accumulate at inflammatory sites during the pathogenesis of various diseases including diabetes, vascular complications, neurodegenerative disorders and cancers, and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction of inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability. Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome. Binds to DNA and promotes extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (By similarity). Mediates phagocytosis by non-professional phagocytes (NPP) and this is enhanced by binding to ligands including RNA, DNA, HMGB1 and histones (By similarity). Promotes NPP-mediated phagocytosis of Saccharomyces cerevisiae spores by binding to RNA attached to the spore wall (By similarity). Also promotes NPP-mediated phagocytosis of apoptotic cells (By similarity). Following DNA damage, recruited to DNA double-strand break sites where it colocalizes with the MRN repair complex via interaction with double-strand break repair protein MRE11 (By similarity). Enhances the endonuclease activity of MRE11, promoting the end resection of damaged DNA (By similarity). Promotes DNA damage repair in trophoblasts which enhances trophoblast invasion and contributes to placental development and maintenance (By similarity). Protects cells from DNA replication stress by localizing to damaged replication forks where it stabilizes the MCM2-7 complex and promotes faithful progression of the replication fork (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 72, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:1904599 advanced glycation end-product binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005769 early endosome", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:2001200 positive regulation of dendritic cell differentiation;GO:0032693 negative regulation of interleukin-10 production;GO:0001914 regulation of T cell mediated cytotoxicity;GO:1904597 negative regulation of connective tissue replacement involved in inflammatory response wound healing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63495-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMG6-1", "uniprot_id": [ { "id": "TFPT_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMG6", "type": "external" } ], "mass": 28908.0, "length": 259, "protein_name": "TCF3 fusion partner homolog", "gene_name": "Tfpt", "organism": "Rat", "refseq_name": "TCF3 fusion partner homolog isoform 1", "refseq_ac": [ { "id": "NP_620225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620225", "type": "external" } ], "gene_names_uniprotkb": "Tfpt; Amida", "gene_names_refseq": "Amida; Tfpt", "protein_names_uniprotkb": "TCF3 fusion partner homolog; Protein amida", "protein_names_refseq": "TCF3 (E2A) fusion partner (in childhood leukemia); TCF3 fusion partner homolog isoform 1; TCF3 fusion partner homolog; protein amida", "tax_id": 10116, "disease": "", "pathway": " (rno:85423); (R-RNO-5689603); (R-RNO-5696394)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10644725;11606057;12841360;16229834;17617061;22673903", "class_list": "", "function": "Amida is involved in spermatogenesis and may play an important role in development of testicular germ cells., [RefSeq, PubMed]; Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis., [RefSeq, PubMed]; Appears to promote apoptosis in a p53/TP53-independent manner., [UniProtKB]; Overexpression of Amida inhibited cell growth, [RefSeq, PubMed]; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair., [UniProtKB]; Results implicate p21Cip1 as an anti-apoptotic protein and suggest a role for polyamines in the regulation of p21Cip1 via the transcription repressor E47, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031011 Ino80 complex", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JMG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI59-1", "uniprot_id": [ { "id": "RNF10_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI59", "type": "external" } ], "mass": 88410.0, "length": 802, "protein_name": "E3 ubiquitin-protein ligase RNF10", "gene_name": "Rnf10", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF10 isoform 1", "refseq_ac": [ { "id": "NP_001011904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011904", "type": "external" } ], "gene_names_uniprotkb": "Rnf10", "gene_names_refseq": "Rnf10", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF10; 2.3.2.27; RING finger protein 10", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF10 isoform 1; E3 ubiquitin-protein ligase RNF10", "tax_id": 10116, "disease": "", "pathway": " (rno:288710)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18941509;29723537;31069631;31173254;36713029", "class_list": "", "function": "E3 ubiquitin-protein ligase that catalyzes monoubiquitination of 40S ribosomal proteins RPS2/us5 and RPS3/us3 in response to ribosome stalling (By similarity). Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC) or elongation (By similarity). The ribosome quality control is activated in response to ribosome subunit imbalance, amino acid starvation or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR) (By similarity). RNF10 acts by mediating monoubiquitination of RPS2/us5 and RPS3/us3: monoubiquitinated RPS2/us5 and RPS3/us3 are then recognized by RIOK3 kinase, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit (By similarity). The action of RNF10 in iRQC is counteracted by USP10 (By similarity). May also act as a transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression (PubMed:18941509). Acts as a regulator of Schwann cell differentiation and myelination (PubMed:18941509)., [UniProtKB, PubMed, UniProtKB]; Low RNF10 expression is associated with neointimal hyperplasia., [RefSeq, PubMed]; Protein kinase C [PKC]-dependent phosphorylation of RNF10 Ser31 was identified as a key step for RNF10 detachment from NMDA receptor and its subsequent trafficking to the nucleus., [RefSeq, PubMed]; RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; The differential expression of RNF10 had a completely opposite effect on vascular damage under hyperglycaemia, further displaying the core function of RNF10 in regulating vascular remodeling induced by diabetes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070651 nonfunctional rRNA decay;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5XI59-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIK5-1", "uniprot_id": [ { "id": "RN146_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIK5", "type": "external" } ], "mass": 38224.0, "length": 352, "protein_name": "E3 ubiquitin-protein ligase RNF146", "gene_name": "Rnf146", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF146", "refseq_ac": [ { "id": "NP_001012060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012060", "type": "external" } ], "gene_names_uniprotkb": "Rnf146", "gene_names_refseq": "Rnf146", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF146; 2.3.2.27; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF146; RING-type E3 ubiquitin transferase RNF146; iduna", "tax_id": 10116, "disease": "osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": " (rno:308051); (R-RNO-201681); (R-RNO-4641257); (R-RNO-5689880); (R-RNO-8948751)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "22673903;24842055;28108258;32326811", "class_list": "", "function": "E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB]; Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes Publication Status: Online-Only, [RefSeq, PubMed]; NPD1 inhibits excessive autophagy by targeting RNF146 and wnt/beta-catenin pathway in cerebral ischemia-reperfusion injury., [RefSeq, PubMed]; Results suggest that apoptosis-inducing factor nuclear translocation and neuronal cell death are associated with Iduna loss after severe hypoxic-ischemic in the immature brain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0071456 cellular response to hypoxia;GO:0070301 cellular response to hydrogen peroxide;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XIK5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VD12-1", "uniprot_id": [ { "id": "PBIP1_RAT", "url": "https://www.uniprot.org/uniprot/A2VD12", "type": "external" } ], "mass": 80276.0, "length": 722, "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "gene_name": "Pbxip1", "organism": "Rat", "refseq_name": "pre-B-cell leukemia transcription factor-interacting protein 1", "refseq_ac": [ { "id": "NP_001094446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094446", "type": "external" } ], "gene_names_uniprotkb": "Pbxip1; Hpip", "gene_names_refseq": "Pbxip1", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor-interacting protein 1; Hematopoietic PBX-interacting protein", "protein_names_refseq": "hematopoietic PBX-interacting protein; pre-B-cell leukemia homeobox interacting protein 1; pre-B-cell leukemia transcription factor-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:310644)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;24090084;38843836", "class_list": "", "function": "Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0022617 extracellular matrix disassembly;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "A2VD12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8N2-1", "uniprot_id": [ { "id": "RN187_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8N2", "type": "external" } ], "mass": 26313.0, "length": 236, "protein_name": "E3 ubiquitin-protein ligase RNF187", "gene_name": "Rnf187", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF187", "refseq_ac": [ { "id": "NP_001157736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157736", "type": "external" } ], "gene_names_uniprotkb": "Rnf187", "gene_names_refseq": "RACO-1; RGD1308636; Rnf187", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF187; 2.3.2.27; RACO-1; RING domain AP1 coactivator 1; RING finger protein 187; RING-type E3 ubiquitin transferase RNF187", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF187; RING domain AP1 coactivator 1; RING-type E3 ubiquitin transferase RNF187", "tax_id": 10116, "disease": "", "pathway": " (rno:360533)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20852630;22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3Z8N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HL2-1", "uniprot_id": [ { "id": "SRC8_RAT", "url": "https://www.uniprot.org/uniprot/Q66HL2", "type": "external" } ], "mass": 56942.0, "length": 509, "protein_name": "Src substrate cortactin", "gene_name": "Cttn", "organism": "Rat", "refseq_name": "src substrate cortactin isoform 2", "refseq_ac": [ { "id": "NP_068640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068640", "type": "external" } ], "gene_names_uniprotkb": "Cttn", "gene_names_refseq": "Cttnb; Cttn", "protein_names_uniprotkb": "Src substrate cortactin", "protein_names_refseq": "src substrate cortactin isoform 2; src substrate cortactin", "tax_id": 10116, "disease": "", "pathway": " (rno:60465)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "12151401;12612086;16854367;17959782;18768925;19995918;21210813;22673903;22952866;23144454;26261183;29515177;32711564;33446758;34426822", "class_list": "", "function": "Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:18768925). Plays a role in the formation of lamellipodia and in cell migration (PubMed:18768925). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (PubMed:21210813). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in focal adhesion assembly and turnover (PubMed:18768925, PubMed:22952866). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (By similarity). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (PubMed:12612086, PubMed:19995918). Required for stabilization of KCNH1 channels at the cell membrane (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane. Plays a role in receptor-mediated endocytosis via clathrin-coated pits. Required for stabilization of KCNH1 channels at the cell membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development. Publication Status: Online-Only, [RefSeq, PubMed]; Cortactin knockdown results in disruption of basal TBCs and alters turnover of Sertoli cell ESs in Rattus norvegicusdagger., [RefSeq, PubMed]; Distribution of cortactin in cerebellar Purkinje cell spines. Publication Status: Online-Only, [RefSeq, PubMed]; The shootin1-cortactin interaction participates in netrin-1-induced F-actin adhesion coupling and in the promotion of traction forces for axon outgrowth., [RefSeq, PubMed]; These results demonstrate that cortactin maintains GluA2/A3 levels by directing receptors away from lysosomes, and that disrupting GluA2-cortactin interactions to target GluA2/A3 to lysosomes is an essential component of LTD expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZRB0", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0070064 proline-rich region binding;GO:0005522 profilin binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005884 actin filament", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0006886 intracellular protein transport;GO:0016477 cell migration;GO:0045987 positive regulation of smooth muscle contraction;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q66HL2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TRW4-1", "uniprot_id": [ { "id": "PDS5B_RAT", "url": "https://www.uniprot.org/uniprot/Q6TRW4", "type": "external" } ], "mass": 164459.0, "length": 1447, "protein_name": "Sister chromatid cohesion protein PDS5 homolog B", "gene_name": "Pds5b", "organism": "Rat", "refseq_name": "sister chromatid cohesion protein PDS5 homolog B isoform X1", "refseq_ac": [ { "id": "XP_038945247", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038945247", "type": "external" } ], "gene_names_uniprotkb": "Pds5b; Aprin; As3", "gene_names_refseq": "AS3; Aprin; CG008; Pds5b", "protein_names_uniprotkb": "Sister chromatid cohesion protein PDS5 homolog B; Androgen-induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff-associated protein AS3", "protein_names_refseq": "sister chromatid cohesion protein PDS5 homolog B isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:304218); (R-RNO-2467813); (R-RNO-2468052); (R-RNO-2470946); (R-RNO-2500257)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12072405;22673903;9459187", "class_list": "", "function": "Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5G5U1;Q5G6V7;Q5G6V8;Q5PY35;Q5PY36", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0140670 cohesin unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0051301 cell division;GO:0007064 mitotic sister chromatid cohesion;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6TRW4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACP5-1", "uniprot_id": [ { "id": "RECQ5_RAT", "url": "https://www.uniprot.org/uniprot/D4ACP5", "type": "external" } ], "mass": 107222.0, "length": 973, "protein_name": "ATP-dependent DNA helicase Q5", "gene_name": "Recql5", "organism": "Rat", "refseq_name": "ATP-dependent DNA helicase Q5", "refseq_ac": [ { "id": "NP_001099323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099323", "type": "external" } ], "gene_names_uniprotkb": "Recql5", "gene_names_refseq": "RecQ5; Recql5", "protein_names_uniprotkb": "ATP-dependent DNA helicase Q5; 5.6.2.4; DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RecQ protein-like 5; RecQ5", "protein_names_refseq": "ATP-dependent DNA helicase Q5; DNA 3'-5' helicase RecQ5; DNA helicase, RecQ-like type 5; RecQ helicase-like 5; RecQ protein-like 5", "tax_id": 10116, "disease": "", "pathway": " (rno:287834)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "DNA helicase that plays an important role in DNA replication, transcription and repair. Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability. Also associates with POLR1A and enforces the stability of ribosomal DNA arrays. Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress. Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0051301 cell division;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ACP5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08700-1", "uniprot_id": [ { "id": "VPS45_RAT", "url": "https://www.uniprot.org/uniprot/O08700", "type": "external" } ], "mass": 64894.0, "length": 570, "protein_name": "Vacuolar protein sorting-associated protein 45", "gene_name": "Vps45", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 45", "refseq_ac": [ { "id": "NP_742069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742069", "type": "external" } ], "gene_names_uniprotkb": "Vps45; Vps45a", "gene_names_refseq": "Vps45; Vsp45a", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 45; rVps45", "protein_names_refseq": "rvps45; vacuolar protein sorting-associated protein 45; vesicular transport protein rvps45", "tax_id": 10116, "disease": "severe congenital neutropenia 5 (Disease Ontology:DOID:0112132)", "pathway": " (rno:64516); (R-RNO-6811438); (R-RNO-983231)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;9106478", "class_list": "", "function": "May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0010008 endosome membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08700-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2B9-1", "uniprot_id": [ { "id": "RM42_RAT", "url": "https://www.uniprot.org/uniprot/P0C2B9", "type": "external" } ], "mass": 16469.0, "length": 141, "protein_name": "Large ribosomal subunit protein mL42", "gene_name": "Mrpl42l1; Mrpl42", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrpl42l1; Mrpl42; LOC685447; Mrpl42l1; Mrpl42; Mrps32", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein mL42; 28S ribosomal protein L42, mitochondrial; 28S ribosomal protein S32, mitochondrial; L42mt; MRP-L42; MRP-S32; S32mt", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:299743); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2B9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11345-1", "uniprot_id": [ { "id": "RAF1_RAT", "url": "https://www.uniprot.org/uniprot/P11345", "type": "external" } ], "mass": 72928.0, "length": 648, "protein_name": "RAF proto-oncogene serine/threonine-protein kinase", "gene_name": "Raf1", "organism": "Rat", "refseq_name": "RAF proto-oncogene serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_036771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036771", "type": "external" } ], "gene_names_uniprotkb": "Raf1; Raf", "gene_names_refseq": "Raf1", "protein_names_uniprotkb": "RAF proto-oncogene serine/threonine-protein kinase; 2.7.11.1; Proto-oncogene c-RAF; Raf-1; cRaf", "protein_names_refseq": "C-RAF; RAF proto-oncogene serine/threonine-protein kinase; cRaf; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); proto-oncogene c-RAF; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-leukemia viral oncogene 1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); prostate cancer (Disease Ontology:DOID:10283); gastric ulcer (Disease Ontology:DOID:10808); disseminated intravascular coagulation (Disease Ontology:DOID:11247); cancer (Disease Ontology:DOID:162); factor XIII deficiency (Disease Ontology:DOID:2211); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); pancreatic carcinoma (Disease Ontology:DOID:4905); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); priapism (Disease Ontology:DOID:9286); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:24703); (R-RNO-2672351); (R-RNO-392517); (R-RNO-430116); (R-RNO-5621575); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-5674499); (R-RNO-5675221); (R-RNO-9732724)", "pathway_count": 10, "publication_count": 22, "publication_id_list": "12419709;15567062;17000055;18243549;18667481;19319189;19381846;19878719;20953701;21917714;22673903;22957439;25367879;28057484;29258870;31521821;33424842;34229010;3550433;7565670;9234708;9931261", "class_list": "", "function": "Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; O-GlcNAcylation suppressed the ubiquitination of RAF1., [RefSeq, PubMed]; Raf-1 kinase contributes to cerebral vasospasm and early brain injury after subarachnoid hemorrhage by enhancing the activation of the Raf-1/ERK1/2 and Raf-1/NF-kappaB signaling pathways. Erratum:[Mol Neurobiol. 2024 Oct;61(10):8490. doi: 10.1007/s12035-024-04153-0. PMID: 38625621], [RefSeq, PubMed]; Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation (By similarity). Phosphorylates TNNT2/cardiac muscle troponin T., [UniProtKB, PubMed, PubMed]; Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a low affinity for cGMP, did not., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0030878 thyroid gland development;GO:0038127 ERBB signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P11345-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21769-1", "uniprot_id": [ { "id": "ODFP1_RAT", "url": "https://www.uniprot.org/uniprot/P21769", "type": "external" } ], "mass": 27351.0, "length": 245, "protein_name": "Outer dense fiber protein 1", "gene_name": "Odf1", "organism": "Rat", "refseq_name": "outer dense fiber protein 1", "refseq_ac": [ { "id": "NP_077040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077040", "type": "external" } ], "gene_names_uniprotkb": "Odf1; Odf27; Odfp; Rt7", "gene_names_refseq": "Odf1", "protein_names_uniprotkb": "Outer dense fiber protein 1; Protein RT7; RTS 5/1", "protein_names_refseq": "RTS 5/1; Sperm outer dense fiber major protein 1; outer dense fiber protein 1", "tax_id": 10116, "disease": "movement disease (Disease Ontology:DOID:480)", "pathway": " (rno:24610)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10373309;12533418;12594206;1699827;1936558;22673903;8179907;8375388", "class_list": "", "function": "Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail., [UniProtKB, UniProtKB, UniProtKB]; OIP1 binds to evolutionarily conserved Cys-Gly-Pro repeats in C-terminus of ODF1. Erratum:[Biol Reprod. 2003 Oct;69(4):1447], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62652;Q63390;Q63534;Q63535", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005813 centrosome;GO:0036126 sperm flagellum;GO:0002177 manchette;GO:0031514 motile cilium", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P21769-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35281-1", "uniprot_id": [ { "id": "RAB10_RAT", "url": "https://www.uniprot.org/uniprot/P35281", "type": "external" } ], "mass": 22858.0, "length": 200, "protein_name": "Ras-related protein Rab-10", "gene_name": "Rab10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab10", "gene_names_refseq": "", "protein_names_uniprotkb": "Ras-related protein Rab-10; 3.6.5.2", "protein_names_refseq": "", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167)", "pathway": " (rno:50993); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1313420;20576682;21856246;24662485", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:24662485). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB10 is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, RAB10 regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane (By similarity). In neurons, involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (PubMed:21856246). In epithelial cells, regulates transport from the Golgi to the basolateral membrane (By similarity). May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route. Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation where it promotes the extracellular release of lysosomal content through EHBP1 and EHNP1L1 effector proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0051021 GDP-dissociation inhibitor binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0007409 axonogenesis;GO:0032869 cellular response to insulin stimulus;GO:0045055 regulated exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35281-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35467-1", "uniprot_id": [ { "id": "S10A1_RAT", "url": "https://www.uniprot.org/uniprot/P35467", "type": "external" } ], "mass": 10560.0, "length": 94, "protein_name": "Protein S100-A1", "gene_name": "S100a1", "organism": "Rat", "refseq_name": "protein S100-A1", "refseq_ac": [ { "id": "NP_001007637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007637", "type": "external" } ], "gene_names_uniprotkb": "S100a1", "gene_names_refseq": "S100a1", "protein_names_uniprotkb": "Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1", "protein_names_refseq": "S-100 protein alpha chain; S-100 protein subunit alpha; protein S100-A1", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:295214); (R-RNO-5686938)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11790100;16169012;1742602;18650434;19452629;19910580;23683996", "class_list": "", "function": "Depletion of S100A1 was observed in ischemic cardiomyocytes, and S100A1 plasma concentration was also significantly higher than that of the sham-operated group Publication Status: Online-Only, [RefSeq, PubMed]; Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:18650434). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity) (PubMed:18650434)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031674 I band", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042311 vasodilation;GO:0008016 regulation of heart contraction;GO:0050790 regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35467-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55090-1", "uniprot_id": [ { "id": "UCN1_RAT", "url": "https://www.uniprot.org/uniprot/P55090", "type": "external" } ], "mass": 13711.0, "length": 122, "protein_name": "Urocortin", "gene_name": "Ucn", "organism": "Rat", "refseq_name": "urocortin precursor", "refseq_ac": [ { "id": "NP_062023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062023", "type": "external" } ], "gene_names_uniprotkb": "Ucn", "gene_names_refseq": "Ucn", "protein_names_uniprotkb": "Urocortin; Corticotensin", "protein_names_refseq": "corticotensin; urocortin precursor", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); Parkinsonism (Disease Ontology:DOID:0080855); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); thromboangiitis obliterans (Disease Ontology:DOID:12918); dilated cardiomyopathy (Disease Ontology:DOID:12930); asthma (Disease Ontology:DOID:2841); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29151); (R-RNO-373080)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10722688;21540451;27659706;27826101;30422021;31073117;32196844;7477349;8703220", "class_list": "", "function": "Effects of early life stress and 5-HTT genotype at the molecular level could constitute early life stress x 5-HTT genotype interaction modulating the impact of stress on Edinger-Westphal-Ucn1 and dorsal raphe-5-HT neurons., [RefSeq, PubMed]; Hormone that plays a central role in whole body adaptation to stress (PubMed:10722688, PubMed:7477349, PubMed:8703220). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptors CRHR1 and CRHR2 (PubMed:8703220). UCN-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:7477349, PubMed:8703220). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451, PubMed:8703220)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Polydatin significantly reduced the inflammatory mediators and restored the normal values of oxidative and nitrosative stress biomarkers. It also significantly reduced the expression of surfactant-D and UCN as compared to asthma control, [RefSeq, PubMed]; Ucn induces activation of STAT3 through diverging signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Urocortin 1: A putative excitatory neurotransmitter in the enteric nervous system., [RefSeq, PubMed]; Urocortin may play a cytoprotective role in the germ cells in response to ischemia-reperfusion injury through the activation of major anti-apoptotic proteins, as well as by the mitogen-activated protein kinase signaling pathway activation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046811 histone deacetylase inhibitor activity;GO:0001664 G protein-coupled receptor binding;GO:0005179 hormone activity;GO:0051430 corticotropin-releasing hormone receptor 1 binding;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0001964 startle response;GO:2000252 negative regulation of feeding behavior;GO:0001934 positive regulation of protein phosphorylation;GO:0006979 response to oxidative stress;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P55090-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56720-2", "uniprot_id": [ { "id": "SRBP1_RAT", "url": "https://www.uniprot.org/uniprot/P56720", "type": "external" } ], "mass": 120521.0, "length": 1134, "protein_name": "Sterol regulatory element-binding protein 1", "gene_name": "Srebf1", "organism": "Rat", "refseq_name": "sterol regulatory element-binding protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001263636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263636", "type": "external" } ], "gene_names_uniprotkb": "Srebf1; Srebp1", "gene_names_refseq": "ADD-1; ADD1; SREBP-1c; SREBP-1; Srebf1; Srebp1", "protein_names_uniprotkb": "Sterol regulatory element-binding protein 1; ADD1; Adipocyte determination- and differentiation-dependent factor 1; SREBP-1; Sterol regulatory element-binding transcription factor 1; Transcription factor SREBF1", "protein_names_refseq": "adipocyte determination- and differentiation-dependent factor 1; sterol regulatory element-binding protein 1 isoform 1 precursor; sterol regulatory element-binding protein 1", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); heart conduction disease (Disease Ontology:DOID:10273); alcoholic hepatitis (Disease Ontology:DOID:12351); alcohol use disorder (Disease Ontology:DOID:1574); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352); lipid storage disease (Disease Ontology:DOID:9455); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:78968); (R-RNO-1655829); (R-RNO-6807062)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11309661;22673903;26589965;34655015;34923569;38079167;38369486;7739539;8336713", "class_list": "", "function": "Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of the hepatic mTOR/S6K1/SREBP1 signalling pathway in rats at different ages: from neonates to adults., [RefSeq, PubMed]; Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (By similarity). Able to stimulate both lipogenic and cholesterogenic gene expression (By similarity). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver. Required for innate immune response in macrophages by regulating lipid metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (PubMed:7739539). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Lanosterol Synthase Prevents EMT During Lens Epithelial Fibrosis Via Regulating SREBP1., [RefSeq, PubMed]; Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (By similarity). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (By similarity). Primarily controls expression of lipogenic gene (By similarity). Strongly activates global lipid synthesis in rapidly growing cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SIRT6 regulates SREBP1c-induced glucolipid metabolism in liver and pancreas via the AMPKalpha-mTORC1 pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q99PI6;Q99PI7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P56720-2", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61589-1", "uniprot_id": [ { "id": "RHOA_RAT", "url": "https://www.uniprot.org/uniprot/P61589", "type": "external" } ], "mass": 21782.0, "length": 193, "protein_name": "Transforming protein RhoA", "gene_name": "Rhoa", "organism": "Rat", "refseq_name": "transforming protein RhoA", "refseq_ac": [ { "id": "NP_476473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476473", "type": "external" } ], "gene_names_uniprotkb": "Rhoa; Arha2; Arha", "gene_names_refseq": "Arha2; Arha; Rhoa", "protein_names_uniprotkb": "Transforming protein RhoA; 3.6.5.2", "protein_names_refseq": "plysia ras-related homolog A2; ras homolog gene family, member A; transforming protein RhoA", "tax_id": 10116, "disease": "fetal alcohol syndrome (Disease Ontology:DOID:0050665); peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); urinary bladder cancer (Disease Ontology:DOID:11054); primary biliary cholangitis (Disease Ontology:DOID:12236); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); breast carcinoma (Disease Ontology:DOID:3459); ovarian carcinoma (Disease Ontology:DOID:4001); pulmonary hypertension (Disease Ontology:DOID:6432); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); acute myocardial infarction (Disease Ontology:DOID:9408); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:117273); (R-RNO-114604); (R-RNO-193634); (R-RNO-198203); (R-RNO-209563); (R-RNO-2173791); (R-RNO-392451); (R-RNO-3928662); (R-RNO-3928663); (R-RNO-4086400); (R-RNO-416482); (R-RNO-416550); (R-RNO-416572); (R-RNO-4420097); (R-RNO-5625740); (R-RNO-5625900); (R-RNO-5625970); (R-RNO-5627117); (R-RNO-5663220); (R-RNO-5666185); (R-RNO-5689896); (R-RNO-6785631); (R-RNO-6798695); (R-RNO-8849471); (R-RNO-8980692); (R-RNO-8985586); (R-RNO-9013106)", "pathway_count": 27, "publication_count": 15, "publication_id_list": "15890975;16109481;18420945;19473460;20696841;21423166;28300846;34088899;35889443;36780962;37003483;37171014;37458218;37864185;9635436", "class_list": "", "function": "Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats., [RefSeq, PubMed]; Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual roles. Publication Status: Online-Only, [RefSeq, PubMed]; Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway., [RefSeq, PubMed]; SiRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells., [RefSeq, PubMed]; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Involved in the reorientation of endothelial cells and their actin stress fibers in response to cellular mechantransduction-mediated activation by ARHGEF40 (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (By similarity). May be an activator of PLCE1 (By similarity). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (PubMed:21423166). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0043297 apical junction assembly;GO:1990869 cellular response to chemokine;GO:0043931 ossification involved in bone maturation;GO:0021861 forebrain radial glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P61589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63012-1", "uniprot_id": [ { "id": "RAB3A_RAT", "url": "https://www.uniprot.org/uniprot/P63012", "type": "external" } ], "mass": 24970.0, "length": 220, "protein_name": "Ras-related protein Rab-3A", "gene_name": "Rab3a", "organism": "Rat", "refseq_name": "ras-related protein Rab-3A", "refseq_ac": [ { "id": "NP_037150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037150", "type": "external" } ], "gene_names_uniprotkb": "Rab3a", "gene_names_refseq": "RAB3; Rab3a", "protein_names_uniprotkb": "Ras-related protein Rab-3A; 3.6.5.2", "protein_names_refseq": "Ras-related small GTP binding protein 3A; ras-related protein Rab-3A", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); factor X deficiency (Disease Ontology:DOID:2222); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:25531); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8876198); (R-RNO-888590)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "10025402;10196122;10748113;17149709;17311845;18407218;21689256;22673903;28057568;28370453;28634303;3317403;3344209;36587525;38253132;7532276;9020086", "class_list": "", "function": "Analysis of crystal structures and biochemical analyses of Rabphilin-3A C2B-SNAP25 and C2B-phosphatidylinositol 4,5-bisphosphate (PIP2) complexes, revealing how Rabphilin-3A C2 domains operate in cooperation with PIP2/Ca(2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the complete SNARE complex, [RefSeq, PubMed]; Rab3A interacts with spastin to regulate neurite outgrowth in hippocampal neurons., [RefSeq, PubMed]; Rab3A-binding site on C2A domain of synaptotagmin I, [RefSeq, PubMed]; Rab3a attenuates spinal cord injury by mediating vesicle release., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:21689256). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (PubMed:18407218). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (PubMed:17149709). Stimulates insulin secretion through interaction with RIMS2 and RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (PubMed:28057568)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This work has shed new light on the molecular mechanism for Rab3 and synaptotamin regulation of neurotransmitter release., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05713", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0051021 GDP-dissociation inhibitor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0030424 axon", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0097091 synaptic vesicle clustering;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0048790 maintenance of presynaptic active zone structure;GO:0050975 sensory perception of touch", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P63012-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63312-1", "uniprot_id": [ { "id": "TYB10_RAT", "url": "https://www.uniprot.org/uniprot/P63312", "type": "external" } ], "mass": 5026.0, "length": 44, "protein_name": "Thymosin beta-10", "gene_name": "Tmsb10", "organism": "Rat", "refseq_name": "thymosin beta-10", "refseq_ac": [ { "id": "NP_067084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067084", "type": "external" } ], "gene_names_uniprotkb": "Tmsb10; Ptmb10; Thyb10", "gene_names_refseq": "Ptmb10; THYb10; Tmsb10", "protein_names_uniprotkb": "Thymosin beta-10", "protein_names_refseq": "prothymosin beta 10; thymosin beta-10", "tax_id": 10116, "disease": "", "pathway": " (rno:50665)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16528249;1744129;1988550;22673903;23807296;3606131", "class_list": "", "function": "A species-specific expression of Tbeta4 and Tbeta10, characterized by the actual unpredictability of the expression of these peptides in different cells and tissues Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)., [UniProtKB]; Thymosin beta10 may play an important role in the progression of kidney disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13472", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007286 spermatid development;GO:0030036 actin cytoskeleton organization;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P63312-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63322-1", "uniprot_id": [ { "id": "RALA_RAT", "url": "https://www.uniprot.org/uniprot/P63322", "type": "external" } ], "mass": 23553.0, "length": 206, "protein_name": "Ras-related protein Ral-A", "gene_name": "Rala", "organism": "Rat", "refseq_name": "ras-related protein Ral-A", "refseq_ac": [ { "id": "NP_112355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112355", "type": "external" } ], "gene_names_uniprotkb": "Rala; Ral-a; Ral", "gene_names_refseq": "Rala", "protein_names_uniprotkb": "Ras-related protein Ral-A; 3.6.5.2", "protein_names_refseq": "RALA Ras like proto-oncogene A; ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)", "tax_id": 10116, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498)", "pathway": " (rno:81757)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15034142;23346930;24165023;7623849;7687439", "class_list": "", "function": "Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (By similarity). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (By similarity). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RalA activation is required for the induction of lamellipodia, and conversely, lamellipodial protrusion seems to be required for the RalA activation, suggesting the presence of a positive feedback loop between RalA activation and lamellipodial protrusion, [RefSeq, PubMed]; RalA modulates insulin release by binding to auxiliary calcium channel subunits on the insulin granules., [RefSeq, PubMed]; Specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05810", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0032154 cleavage furrow", "go_biological_process": "GO:0051665 membrane raft localization;GO:0031623 receptor internalization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051301 cell division;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P63322-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81128-1", "uniprot_id": [ { "id": "RHG35_RAT", "url": "https://www.uniprot.org/uniprot/P81128", "type": "external" } ], "mass": 170480.0, "length": 1499, "protein_name": "Rho GTPase-activating protein 35", "gene_name": "Arhgap35", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 35", "refseq_ac": [ { "id": "NP_001258061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258061", "type": "external" } ], "gene_names_uniprotkb": "Arhgap35; Grlf1; P190A; p190ARHOGAP", "gene_names_refseq": "Arhgap35; Grlf1; p190RhoGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 35; GAP-associated protein p190; Glucocorticoid receptor DNA-binding factor 1", "protein_names_refseq": "GAP-associated protein p190; glucocorticoid receptor DNA-binding factor 1; rho GTPase-activating protein 35", "tax_id": 10116, "disease": "", "pathway": " (rno:306400); (R-RNO-416550); (R-RNO-8849471); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013409); (R-RNO-9013423); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 16, "publication_count": 7, "publication_id_list": "1581965;20439493;22673903;27212270;27646271;30174148;9852136", "class_list": "", "function": "RACK1 promotes adhesion-mediated activation of ERK2 that in turn inhibits p190A-RhoGAP signaling by reducing the peripheral localization of p190A-RhoGAP., [RefSeq, PubMed]; Results find that N-GTPase adopts an extended GTPase-like fold with six unique inserts. It bounds constitutively to GTP/Mg2+ and lacks intrinsic catalytic activity. Mutational analysis shows that GTP and Mg2+ binding stabilizes the domain. This data supports both that p190RhoGAP N-GTPase is a nucleotide binding, non-hydrolyzing, pseudoGTPase domain that cannot bind canonical ligands, acting as a protein-protein module., [RefSeq, PubMed]; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:20439493, PubMed:9852136). This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (PubMed:20439493, PubMed:9852136). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; The molecular processes responsible for p190A targeting to actin protrusions, were studied., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2KB46", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0097485 neuron projection guidance;GO:0008064 regulation of actin polymerization or depolymerization;GO:0006351 DNA-templated transcription;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81128-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83565-1", "uniprot_id": [ { "id": "RM40_RAT", "url": "https://www.uniprot.org/uniprot/P83565", "type": "external" } ], "mass": 24397.0, "length": 206, "protein_name": "Large ribosomal subunit protein mL40", "gene_name": "Mrpl40", "organism": "Rat", "refseq_name": "large ribosomal subunit protein mL40 precursor", "refseq_ac": [ { "id": "NP_001020036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020036", "type": "external" } ], "gene_names_uniprotkb": "Mrpl40", "gene_names_refseq": "Mrpl40", "protein_names_uniprotkb": "Large ribosomal subunit protein mL40; 39S ribosomal protein L40, mitochondrial; L40mt; MRP-L40", "protein_names_refseq": "39S ribosomal protein L40, mitochondrial; L40mt; MRP-L40; large ribosomal subunit protein mL40 precursor; large ribosomal subunit protein mL40", "tax_id": 10116, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); DiGeorge syndrome (Disease Ontology:DOID:11198)", "pathway": " (rno:287962); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8A4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005761 mitochondrial ribosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08851-1", "uniprot_id": [ { "id": "STX5_RAT", "url": "https://www.uniprot.org/uniprot/Q08851", "type": "external" } ], "mass": 39751.0, "length": 355, "protein_name": "Syntaxin-5", "gene_name": "Stx5", "organism": "Rat", "refseq_name": "syntaxin-5", "refseq_ac": [ { "id": "NP_113892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113892", "type": "external" } ], "gene_names_uniprotkb": "Stx5; Stx5a", "gene_names_refseq": "Stx5a; Stx5", "protein_names_uniprotkb": "Syntaxin-5", "protein_names_refseq": "syntaxin 5a; syntaxin-5", "tax_id": 10116, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571)", "pathway": " (rno:65134); (R-RNO-204005); (R-RNO-5694530); (R-RNO-6807878); (R-RNO-6811438); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9013408); (R-RNO-9609523)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10930451;11323436;12388752;14742712;18167358;25596448;27366738;29393594;7690687;9307973;9506515", "class_list": "", "function": "Mediates endoplasmic reticulum to Golgi transport (PubMed:10930451, PubMed:14742712, PubMed:9506515). Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:18167358)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus., [UniProtKB, UniProtKB]; O3 exposure (0.25 ppm) induced a significant increase of Syntaxin 5 and accumulation of betaA42 peptide in the reticulum in cells of the dentate gyrus, [RefSeq, PubMed]; Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Syx5 plays important roles in beta-amyloid precursor protein processing and in the endoplasmic reticulum stress response., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JPL4;O55200", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0031982 vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08851-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497B2-1", "uniprot_id": [ { "id": "TM45B_RAT", "url": "https://www.uniprot.org/uniprot/Q497B2", "type": "external" } ], "mass": 32338.0, "length": 278, "protein_name": "Transmembrane protein 45B", "gene_name": "Tmem45b", "organism": "Rat", "refseq_name": "transmembrane protein 45B", "refseq_ac": [ { "id": "NP_001028239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028239", "type": "external" } ], "gene_names_uniprotkb": "Tmem45b", "gene_names_refseq": "RGD1305586; Tmem45b", "protein_names_uniprotkb": "Transmembrane protein 45B", "protein_names_refseq": "transmembrane protein 45B", "tax_id": 10116, "disease": "", "pathway": " (rno:315524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in innate immunity. Essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0048265 response to pain", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q497B2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KMA2-1", "uniprot_id": [ { "id": "RD23B_RAT", "url": "https://www.uniprot.org/uniprot/Q4KMA2", "type": "external" } ], "mass": 43497.0, "length": 415, "protein_name": "Lysine-specific demethylase RAD23B", "gene_name": "Rad23b", "organism": "Rat", "refseq_name": "lysine-specific demethylase RAD23B", "refseq_ac": [ { "id": "NP_001020446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020446", "type": "external" } ], "gene_names_uniprotkb": "Rad23b", "gene_names_refseq": "Rad23b", "protein_names_uniprotkb": "Lysine-specific demethylase RAD23B; 1.14.11.-; UV excision repair protein RAD23 homolog B", "protein_names_refseq": "RAD23 homolog B, nucleotide excision repair protein; RAD23b homolog; UV excision repair protein RAD23 homolog B; lysine-specific demethylase RAD23B", "tax_id": 10116, "disease": "", "pathway": " (rno:298012); (R-RNO-532668); (R-RNO-5689877); (R-RNO-5696394); (R-RNO-5696395)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "16641100;17496889;18683930;19322778;22673903", "class_list": "", "function": "Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA. Recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix including single-stranded loops, mismatched bubbles or single-stranded overhangs. Cooperatively with CETN2 appears to stabilize XPC., [UniProtKB, UniProtKB]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0D2G8;Q5CZZ8;Q6IRD5", "ec_number_list": [ { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q4KMA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FWT8-1", "uniprot_id": [ { "id": "RCOR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FWT8", "type": "external" } ], "mass": 57981.0, "length": 523, "protein_name": "REST corepressor 2", "gene_name": "Rcor2-ps1; Rcor2", "organism": "Rat", "refseq_name": "REST corepressor 2", "refseq_ac": [ { "id": "NP_001014016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014016", "type": "external" } ], "gene_names_uniprotkb": "Rcor2-ps1; Rcor2; Rcor2-ps1", "gene_names_refseq": "Rcor2", "protein_names_uniprotkb": "REST corepressor 2", "protein_names_refseq": "RE1-silencing transcription factor (REST) co-repressor 2; REST corepressor 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:305811)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22371606;22673903;24111946", "class_list": "", "function": "Data show that neuronal insults trigger activation of REST and CoREST in a clinically relevant model of ischemic stroke and that REST binds a subset of transcriptionally responsive genes., [RefSeq, PubMed]; May act as a component of a corepressor complex that represses transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphorylation, without affecting demethylase activity, causes in neurons CoREST and HDAC1/2 corepressors detachment from LSD1-8a, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5FWT8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0E6-1", "uniprot_id": [ { "id": "RPAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0E6", "type": "external" } ], "mass": 67892.0, "length": 609, "protein_name": "RNA polymerase II subunit B1 CTD phosphatase Rpap2", "gene_name": "Rpap2", "organism": "Rat", "refseq_name": "RNA polymerase II subunit B1 CTD phosphatase Rpap2", "refseq_ac": [ { "id": "NP_001014009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014009", "type": "external" } ], "gene_names_uniprotkb": "Rpap2", "gene_names_refseq": "RGD1309034; Rpap2", "protein_names_uniprotkb": "RNA polymerase II subunit B1 CTD phosphatase Rpap2; 3.1.3.16; Putative RNA polymerase II-associated protein 2", "protein_names_refseq": "RNA polymerase II subunit B1 CTD phosphatase Rpap2; putative RNA polymerase II-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:305120); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;41018975", "class_list": "", "function": "Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A5J9;D4A672", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0043175 RNA polymerase core enzyme binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009301 snRNA transcription;GO:0036499 PERK-mediated unfolded protein response;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5I0E6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U312-1", "uniprot_id": [ { "id": "RAI14_RAT", "url": "https://www.uniprot.org/uniprot/Q5U312", "type": "external" } ], "mass": 109134.0, "length": 978, "protein_name": "Ankycorbin", "gene_name": "Rai14", "organism": "Rat", "refseq_name": "ankycorbin isoform 2", "refseq_ac": [ { "id": "NP_001011947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011947", "type": "external" } ], "gene_names_uniprotkb": "Rai14", "gene_names_refseq": "Rai14", "protein_names_uniprotkb": "Ankycorbin; Ankyrin repeat and coiled-coil structure-containing protein; Retinoic acid-induced protein 14", "protein_names_refseq": "ankycorbin isoform 2; ankycorbin; ankyrin repeat and coiled-coil structure-containing protein; retinoic acid-induced protein 14", "tax_id": 10116, "disease": "", "pathway": " (rno:294804)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;23565266;29393594", "class_list": "", "function": "Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier., [UniProtKB, PubMed]; Rai14 is involved in the re-organization of actin filaments in Sertoli cells during the epithelial cycle, participating in conferring spermatid polarity and cell adhesion in the testis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005938 cell cortex;GO:0001725 stress fiber;GO:0070161 anchoring junction", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U312-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63941-1", "uniprot_id": [ { "id": "RAB3B_RAT", "url": "https://www.uniprot.org/uniprot/Q63941", "type": "external" } ], "mass": 24785.0, "length": 219, "protein_name": "Ras-related protein Rab-3B", "gene_name": "Rab3b", "organism": "Rat", "refseq_name": "ras-related protein Rab-3B", "refseq_ac": [ { "id": "NP_112353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112353", "type": "external" } ], "gene_names_uniprotkb": "Rab3b", "gene_names_refseq": "Rab3b", "protein_names_uniprotkb": "Ras-related protein Rab-3B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-3B", "tax_id": 10116, "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:81755); (R-RNO-8873719)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10748113;22673903;7508866;9245721;9252191", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission;GO:0015031 protein transport;GO:0097494 regulation of vesicle size;GO:0006887 exocytosis;GO:0018125 peptidyl-cysteine methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63941-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH3-1", "uniprot_id": [ { "id": "RNF34_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH3", "type": "external" } ], "mass": 42681.0, "length": 381, "protein_name": "E3 ubiquitin-protein ligase RNF34", "gene_name": "Rnf34", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF34", "refseq_ac": [ { "id": "NP_001004075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004075", "type": "external" } ], "gene_names_uniprotkb": "Rnf34", "gene_names_refseq": "Momo; Rnf34", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF34; 2.3.2.27; RING finger protein 34; RING finger protein MOMO; RING-type E3 ubiquitin transferase RNF34", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF34; RING finger protein MOMO; RING-type E3 ubiquitin transferase RNF34; ring finger protein 34, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:282845); (R-RNO-6804757); (R-RNO-983168)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12859687;25193658;28902127", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation., [UniProtKB, PubMed, UniProtKB]; Identified two novel Ub ligases, Momo and Sakura, carrying double zinc finger motif and RING finger domain; momo expression is enriched in the brain gray matter and testis, [RefSeq, PubMed]; RNF34 regulates postsynaptic gamma2-GABAAR clustering and GABAergic synaptic innervation by interacting with and ubiquitinating the gamma2-GABAAR subunit promoting GABAAR degradation, [RefSeq, PubMed]; Results suggest that exercise therapy possibly involves pain relief in SNL rats by suppressing Rnf34 and Pacap expression in the spinal cord. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIP0", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:1901981 phosphatidylinositol phosphate binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070417 cellular response to cold;GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;GO:2000374 regulation of oxygen metabolic process;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYJ4-1", "uniprot_id": [ { "id": "REC8_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYJ4", "type": "external" } ], "mass": 67874.0, "length": 593, "protein_name": "Meiotic recombination protein REC8 homolog", "gene_name": "Rec8", "organism": "Rat", "refseq_name": "meiotic recombination protein REC8 homolog", "refseq_ac": [ { "id": "NP_001011916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011916", "type": "external" } ], "gene_names_uniprotkb": "Rec8; Rec8L1", "gene_names_refseq": "Rec8L1; Rec8", "protein_names_uniprotkb": "Meiotic recombination protein REC8 homolog; Cohesin Rec8p", "protein_names_refseq": "REC8 homolog; REC8-like 1; cohesin Rec8p; meiosis specific sister chromatid cohesion protein; meiotic recombination protein REC8 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290227)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12615909;22673903", "class_list": "", "function": "Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6QQR2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0030893 meiotic cohesin complex;GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0000793 condensed chromosome;GO:0001673 male germ cell nucleus", "go_biological_process": "GO:0009566 fertilization;GO:0007286 spermatid development;GO:0006302 double-strand break repair;GO:0001556 oocyte maturation;GO:0072520 seminiferous tubule development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUD9-1", "uniprot_id": [ { "id": "SRC_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUD9", "type": "external" } ], "mass": 59973.0, "length": 536, "protein_name": "Proto-oncogene tyrosine-protein kinase Src", "gene_name": "Src", "organism": "Rat", "refseq_name": "proto-oncogene tyrosine-protein kinase Src isoform b", "refseq_ac": [ { "id": "NP_114183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114183", "type": "external" } ], "gene_names_uniprotkb": "Src", "gene_names_refseq": "Src", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase Src; 2.7.10.2; Proto-oncogene c-Src; p60-Src; pp60c-src", "protein_names_refseq": "Rous sarcoma oncogene; c-Src; p60-Src; pp60c-src; proto-oncogene c-Src; proto-oncogene tyrosine-protein kinase Src isoform b; proto-oncogene tyrosine-protein kinase Src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); Parkinsonism (Disease Ontology:DOID:0080855); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); lesion of sciatic nerve (Disease Ontology:DOID:12528); colon carcinoma (Disease Ontology:DOID:1520); thrombocytopenia (Disease Ontology:DOID:1588); status epilepticus (Disease Ontology:DOID:1824); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); Goldenhar syndrome (Disease Ontology:DOID:2907); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic acinar cell adenocarcinoma (Disease Ontology:DOID:5742); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:83805); (R-RNO-1227986); (R-RNO-1251985); (R-RNO-1253288); (R-RNO-1257604); (R-RNO-1295596); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-177929); (R-RNO-180292); (R-RNO-186763); (R-RNO-191650); (R-RNO-2029481); (R-RNO-210990); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-389356); (R-RNO-389513); (R-RNO-3928662); (R-RNO-3928663); (R-RNO-3928664); (R-RNO-3928665); (R-RNO-418592); (R-RNO-418594); (R-RNO-418885); (R-RNO-430116); (R-RNO-437239); (R-RNO-4420097); (R-RNO-456926); (R-RNO-5218921); (R-RNO-5607764); (R-RNO-5673000); (R-RNO-5674135); (R-RNO-6811558); (R-RNO-69231); (R-RNO-8853659); (R-RNO-8874081); (R-RNO-8934903); (R-RNO-8941858); (R-RNO-9009391); (R-RNO-9603381); (R-RNO-9766229); (R-RNO-9958810)", "pathway_count": 44, "publication_count": 18, "publication_id_list": "10995467;11249956;11884411;12473651;15546918;15735685;16186108;17192280;19948503;22673903;26026271;27379421;28220894;29093677;32753687;34662809;35043508;8849729", "class_list": "", "function": "Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (By similarity). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm (By similarity). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated calcium-activated chloride channel activation (By similarity). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, active SRC is recruited, together with the phosphatase DUSP18, to the KISS1R C-terminus. This leads to DUSP18-mediated SRC dephosphorylation and inactivation, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (By similarity). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-738'. Enhances RIGI-elicited antiviral signaling. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376'. Phosphorylates BCAR1 at 'Tyr-226'. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity. Phosphorylates synaptic vesicle protein synaptophysin (SYP) (PubMed:26026271). Involved in anchorage-independent cell growth (By similarity). Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration (By similarity). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (By similarity). Mediates laminin-induced activation of RAC1 signaling through phosphorylation of syntrophin (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Non-receptor protein tyrosine kinase which phosphorylates synaptophysin with high affinity., [UniProtKB, PubMed]; Non-receptor protein tyrosine kinase which shows higher basal kinase activity than isoform 1, possibly due to weakened intramolecular interactions which enhance autophosphorylation of Tyr-419 and subsequent activation (PubMed:26026271). The SH3 domain shows reduced affinity with the linker sequence between the SH2 and kinase domains which may account for the increased basal activity (PubMed:26026271). Displays altered substrate specificity compared to isoform 1, showing weak affinity for synaptophysin and for peptide substrates containing class I or class II SH3 domain-binding motifs (PubMed:26026271). Plays a role in L1CAM-mediated neurite elongation, possibly by acting downstream of L1CAM to drive cytoskeletal rearrangements involved in neurite outgrowth (PubMed:28220894)., [UniProtKB, PubMed, PubMed]; Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system., [RefSeq, PubMed]; Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V776;Q45QJ2;Q9JJ10", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0071253 connexin binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0099073 mitochondrion-derived vesicle;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:2000641 regulation of early endosome to late endosome transport;GO:0046579 positive regulation of Ras protein signal transduction;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0071897 DNA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9WUD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1BPI0-1", "uniprot_id": [ { "id": "OAZ3_RAT", "url": "https://www.uniprot.org/uniprot/A1BPI0", "type": "external" } ], "mass": 28185.0, "length": 243, "protein_name": "Ornithine decarboxylase antizyme 3", "gene_name": "Oaz3", "organism": "Rat", "refseq_name": "ornithine decarboxylase antizyme 3", "refseq_ac": [ { "id": "NP_001094488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094488", "type": "external" } ], "gene_names_uniprotkb": "Oaz3", "gene_names_refseq": "Az3; ODC-Az 3; Oaz-t; Oaz3", "protein_names_uniprotkb": "Ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3", "protein_names_refseq": "antizyme 3; ornithine decarboxylase antizyme 3", "tax_id": 10116, "disease": "", "pathway": " (rno:689588); (R-RNO-350562); (R-RNO-351202)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "17040916;21712390;22673903", "class_list": "", "function": "Does not possess antizyme activity. Modulates PPP1CB activity through its interaction with PPP1R16A., [UniProtKB, PubMed]; N-terminal protein sequencing suggests translation initiation from a non-AUG (CUG) start site., [RefSeq, PubMed]; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity., [RefSeq, PubMed]; The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) codon that is highly conserved among the antizyme 3 orthologs. [provided by RefSeq, Dec 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LSS2", "ec_number_list": [], "go_molecular_function": "GO:0008073 ornithine decarboxylase inhibitor activity;GO:0071532 ankyrin repeat binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:1902268 negative regulation of polyamine transmembrane transport;GO:0090316 positive regulation of intracellular protein transport;GO:0045732 positive regulation of protein catabolic process;GO:0051497 negative regulation of stress fiber assembly;GO:0075523 viral translational frameshifting", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1BPI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62025-1", "uniprot_id": [ { "id": "PHAR2_RAT", "url": "https://www.uniprot.org/uniprot/P62025", "type": "external" } ], "mass": 62201.0, "length": 569, "protein_name": "Phosphatase and actin regulator 2", "gene_name": "Phactr2", "organism": "Rat", "refseq_name": "phosphatase and actin regulator 2 isoform 2", "refseq_ac": [ { "id": "NP_999623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999623", "type": "external" } ], "gene_names_uniprotkb": "Phactr2", "gene_names_refseq": "Phactr2", "protein_names_uniprotkb": "Phosphatase and actin regulator 2", "protein_names_refseq": "phosphatase and actin regulator 2 isoform 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (rno:308291); (R-RNO-114608)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15107502;16641100;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62025-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35987-1", "uniprot_id": [ { "id": "NSF1C_RAT", "url": "https://www.uniprot.org/uniprot/O35987", "type": "external" } ], "mass": 40680.0, "length": 370, "protein_name": "NSFL1 cofactor p47", "gene_name": "Nsfl1c", "organism": "Rat", "refseq_name": "NSFL1 cofactor p47", "refseq_ac": [ { "id": "NP_114187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114187", "type": "external" } ], "gene_names_uniprotkb": "Nsfl1c", "gene_names_refseq": "Nsfl1c; XY40; p47", "protein_names_uniprotkb": "NSFL1 cofactor p47; XY body-associated protein XY40; p97 cofactor p47", "protein_names_refseq": "NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; XY body-associated protein XY40; p97 cofactor p47", "tax_id": 10116, "disease": "", "pathway": " (rno:83809); (R-RNO-9013407)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10811609;10930451;11478859;12146947;12411482;12473691;12810701;1495983;14988733;15029246;16641100;20691684;22673903;23295407;23429921;23649807;9214505;9297509;9506515;9824302", "class_list": "", "function": "Data suggest that NADPH oxidase-derived cytosolic superoxide is increased in islets upon oleate infusion and leads to beta cell dysfunction; whole-body NADPH oxidase inhibition (via apocynin) decreases superoxide and restores islet function., [RefSeq, PubMed]; In the kidneys of bile duct ligated rats melatonin inhibits protein kinase C beta to reduce p47phox superoxide production., [RefSeq, PubMed]; P47(F253S) could not form a complex with p97 and did not cause any cisternal regrowth in an in vitro Golgi reassembly assay., [RefSeq, PubMed]; Reduces the ATPase activity of VCP (PubMed:9214505, PubMed:9824302). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (PubMed:12411482). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (PubMed:10930451). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 12, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O35987-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY60-1", "uniprot_id": [ { "id": "PKHA8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY60", "type": "external" } ], "mass": 58096.0, "length": 520, "protein_name": "Pleckstrin homology domain-containing family A member 8", "gene_name": "Plekha8", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family A member 8", "refseq_ac": [ { "id": "NP_001102705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102705", "type": "external" } ], "gene_names_uniprotkb": "Plekha8; Fapp2", "gene_names_refseq": "FAPP-2; Plekha8; RGD1563940", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family A member 8; FAPP-2; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositol 4-phosphate adapter protein 2", "protein_names_refseq": "PH domain-containing family A member 8; phosphatidylinositol-four-phosphate adapter protein 2; phosphoinositol 4-phosphate adapter protein 2; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; pleckstrin homology domain-containing family A member 8", "tax_id": 10116, "disease": "", "pathway": " (rno:500132); (R-RNO-1660499); (R-RNO-9845576)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation., [UniProtKB, UniProtKB]; Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability (By similarity). Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0097001 ceramide binding;GO:1902387 ceramide 1-phosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0006869 lipid transport;GO:0015031 protein transport;GO:0035621 ER to Golgi ceramide transport;GO:0120009 intermembrane lipid transfer", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZY60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70496-1", "uniprot_id": [ { "id": "PLD1_RAT", "url": "https://www.uniprot.org/uniprot/P70496", "type": "external" } ], "mass": 123814.0, "length": 1074, "protein_name": "Phospholipase D1", "gene_name": "Pld1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pld1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase D1; 3.1.4.4; Choline phosphatase 1; PLD 1; Phosphatidylcholine-hydrolyzing phospholipase D1; rPLD1", "protein_names_refseq": "", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); developmental cardiac valvular defect (Disease Ontology:DOID:0080633); prostate cancer (Disease Ontology:DOID:10283); lymphoid leukemia (Disease Ontology:DOID:1037); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); intracranial aneurysm (Disease Ontology:DOID:10941); arteriovenous malformation (Disease Ontology:DOID:11294); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); cholestasis (Disease Ontology:DOID:13580); breast cancer (Disease Ontology:DOID:1612); coronary artery disease (Disease Ontology:DOID:3393); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25096); (R-RNO-1483166); (R-RNO-2029485); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013149); (R-RNO-9013408)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10441128;11121416;22673903;8753790;9361006;9445394;9533024", "class_list": "", "function": "Function as phospholipase selective for phosphatidylcholine (By similarity). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08959;O35856;O54765;P70497;Q9QWJ6", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0006654 phosphatidic acid biosynthetic process;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70496-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32182-1", "uniprot_id": [ { "id": "FOXA2_RAT", "url": "https://www.uniprot.org/uniprot/P32182", "type": "external" } ], "mass": 48484.0, "length": 458, "protein_name": "Hepatocyte nuclear factor 3-beta", "gene_name": "Foxa2", "organism": "Rat", "refseq_name": "hepatocyte nuclear factor 3-beta isoform 2", "refseq_ac": [ { "id": "NP_036875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036875", "type": "external" } ], "gene_names_uniprotkb": "Foxa2; Hnf3b; Tcf-3b; Tcf3b", "gene_names_refseq": "Foxa2; Hnf3b", "protein_names_uniprotkb": "Hepatocyte nuclear factor 3-beta; Forkhead box protein A2; HNF-3-beta; HNF-3B", "protein_names_refseq": "HNF-3-beta; HNF-3B; forkhead box protein A2; hepatocyte nuclear factor 3-beta isoform 2; hepatocyte nuclear factor 3-beta", "tax_id": 10116, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25099)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10748198;10931833;1324404;14500912;1672118;19478084;19589781;30082727;30341519;31843527;32495363;38135007;7739897;8139574", "class_list": "", "function": "FOXA2 knockdown significantly increased osteoblast-specific gene expression, the number of mineral deposits and alkaline phosphatase activity, whereas FOXA2 overexpression inhibited osteogenesis-specific activities. Moreover, extracellular signal-regulated protein kinase (ERK) signalling was upregulated following knockdown of FOXA2. Publication Status: Online-Only, [RefSeq, PubMed]; FXR controls insulin content by regulating Foxa2-mediated insulin transcription., [RefSeq, PubMed]; FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis., [RefSeq, PubMed]; Low FOXA2 expression is associated with congenital diaphragmatic hernia., [RefSeq, PubMed]; The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)...It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases, [RefSeq, PubMed]; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis (By similarity). Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P32182-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08587-1", "uniprot_id": [ { "id": "NUP50_RAT", "url": "https://www.uniprot.org/uniprot/O08587", "type": "external" } ], "mass": 49818.0, "length": 467, "protein_name": "Nuclear pore complex protein Nup50", "gene_name": "Nup50", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup50", "refseq_ac": [ { "id": "NP_037123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037123", "type": "external" } ], "gene_names_uniprotkb": "Nup50; Npap60", "gene_names_refseq": "Npap60; Nup50; Rtp60", "protein_names_uniprotkb": "Nuclear pore complex protein Nup50; 50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50", "protein_names_refseq": "50 kDa nucleoporin; Nucleoprotein 50kD; nuclear pore associated protein; nuclear pore complex protein Nup50; nucleoporin 50 kDa; nucleoporin Nup50; nucleoprotein 50", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:25497); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "10891499;9073512", "class_list": "", "function": "Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR93", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0051028 mRNA transport;GO:0006606 protein import into nucleus;GO:0001841 neural tube formation;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08587-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01039-1", "uniprot_id": [ { "id": "CYTA_RAT", "url": "https://www.uniprot.org/uniprot/P01039", "type": "external" } ], "mass": 11563.0, "length": 103, "protein_name": "Cystatin-A", "gene_name": "Csta; Stfa3", "organism": "Rat", "refseq_name": "cystatin-A", "refseq_ac": [ { "id": "NP_001099347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099347", "type": "external" } ], "gene_names_uniprotkb": "Csta; Stfa3", "gene_names_refseq": "Csta; Stfa3", "protein_names_uniprotkb": "Cystatin-A; Cystatin-alpha; Epidermal stefin; Epidermal thiol proteinase inhibitor", "protein_names_refseq": "cystatin-A; cystatin-alpha; epidermal stefin; epidermal thiol proteinase inhibitor", "tax_id": 10116, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523)", "pathway": " (rno:288067); (rno:288075)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2205237;6732797", "class_list": "", "function": "This is an intracellular thiol proteinase inhibitor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0002020 protease binding", "go_cellular_component": "GO:0005829 cytosol;GO:0001533 cornified envelope;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:1904090 peptidase inhibitor complex", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0018149 peptide cross-linking;GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01039-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08937-1", "uniprot_id": [ { "id": "OBP_RAT", "url": "https://www.uniprot.org/uniprot/P08937", "type": "external" } ], "mass": 19699.0, "length": 172, "protein_name": "Odorant-binding protein", "gene_name": "Obp1f", "organism": "Rat", "refseq_name": "odorant-binding protein precursor", "refseq_ac": [ { "id": "NP_620258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620258", "type": "external" } ], "gene_names_uniprotkb": "Obp1f; LOC108348181", "gene_names_refseq": "Obp-1f; Obp1f", "protein_names_uniprotkb": "Odorant-binding protein; OBP", "protein_names_refseq": "OBP; odorant-binding protein 1F; odorant-binding protein precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:192267)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15047593;16849331;17584948;19390145;19688223;20932975;3388043", "class_list": "", "function": "A three-dimensional structure of OBP-1F, modelled using the known structure of aphrodisin as template, allowed us to suggest the location of the observed structural changes outside of the binding pocket., [RefSeq, PubMed]; Comparisons are made between this 1.6A resolution structure and a modelled OBP1 structure based on aphrodisin, and with OPB2 and OBP3. It is monomeric., [RefSeq, PubMed]; Lipocalin strand pair opening in the presence of ligand is observed, consistent with potential role in olfactive receptor recognition., [RefSeq, PubMed]; Measured the effect of odorant-binding protein 1 on the rates of ligand uptake and liquid-to-air transfer rates with a set of defined odorous compounds, [RefSeq, PubMed]; Results identify a novel population of odorant-binding protein-1f-secreting cells displaying morphological and functional characteristics similar to those of epithelial mucous cells., [RefSeq, PubMed]; The fine transcriptional control of OBP-1F in the olfactory mucosa following food deprivation could be efficient only at the local level, close to its site of secretion to participate in the perireceptor events of the olfactory signal reception., [RefSeq, PubMed]; This protein is found in nasal epithelium and it binds a wide variety of chemical odorants., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P08937-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TPL3-1", "uniprot_id": [ { "id": "BACD3_RAT", "url": "https://www.uniprot.org/uniprot/Q7TPL3", "type": "external" } ], "mass": 35745.0, "length": 315, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3", "gene_name": "Kctd10", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3", "refseq_ac": [ { "id": "NP_001009973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009973", "type": "external" } ], "gene_names_uniprotkb": "Kctd10", "gene_names_refseq": "Kctd10", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; BTB/POZ domain-containing protein KCTD10", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:494521)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15982757", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination. Controls endothelial barrier function by mediating 'Lys-63'-linked polyubiquitination of RHOB, promoting its lysosomal degradation. Mediates polyubiquitination of CEP97, targeting it for proteasomal degradation. CEP97 degradation upon serum starvation is essential for primary cilium formation by enabling removal of the CEP97-CP110 complex from mother centrioles. Acts as a positive regulator of ferroptosis by destabilizing SLC7A11. Decreased SLC7A11 levels reduce cystine uptake and glutathione (GSH) biosynthesis, thereby promoting iron-dependent lipid peroxidation and ferroptotic cell death. In the innate immune response, mediates 'Lys-27'-linked polyubiquitination of TICAM1/TRIF at Lys-523 upon stimulation with LPS. This ubiquitination is essential for recruitment of TICAM1 to TLR3/4, thereby promoting TLR3/4-mediated immune signaling (By similarity). Negatively regulates KCTD13 stability through the ubiquitin/proteasome degradation pathway within the developing brain to control neuronal progenitor cell proliferation and differentiation (By similarity). Acts as a sensor for co-directional transcription-replication conflicts, where it helps coordinate the interaction between the replication machinery and RNA polymerase to allow DNA replication to continue through actively transcribed regions. Promotes recruitment of ubiquitin ligase complexes that remove stalled transcription factors, thereby maintaining genome stability by resolving these conflicts. Ubiquitinates TCEA2 to remodel the RNAP complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0036038 MKS complex;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0005634 nucleus", "go_biological_process": "GO:0001525 angiogenesis;GO:0007507 heart development;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TPL3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2MJT0-1", "uniprot_id": [ { "id": "MEF2A_RAT", "url": "https://www.uniprot.org/uniprot/Q2MJT0", "type": "external" } ], "mass": 53254.0, "length": 495, "protein_name": "Myocyte-specific enhancer factor 2A", "gene_name": "Mef2a", "organism": "Rat", "refseq_name": "myocyte-specific enhancer factor 2A isoform 3", "refseq_ac": [ { "id": "NP_001014057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014057", "type": "external" } ], "gene_names_uniprotkb": "Mef2a", "gene_names_refseq": "Mef2a", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2A", "protein_names_refseq": "myocyte-specific enhancer factor 2A isoform 3; myocyte-specific enhancer factor 2A", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:309957); (R-RNO-525793)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "16484498;17367767;17855618;22673903;29678571;29783071;29928931;32485181;37660209", "class_list": "", "function": "Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5., [RefSeq, PubMed]; Exercise increases MEF2A abundance in rat cardiac muscle by downregulating microRNA-223-5p. Publication Status: Online-Only, [RefSeq, PubMed]; MEF2A is a transcriptional regulator for Capn3 gene expression., [RefSeq, PubMed]; MEF2A participates in neuronal differentiation/maturation from neural stem cells., [RefSeq, PubMed]; The present study reveals a previously unknown OTR-coupled MAPK-MEF-2A pathway, which is responsible for oxytocin-induced neurite retraction of hypothalamic neurons., [RefSeq, PubMed]; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HD7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q2MJT0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49186-1", "uniprot_id": [ { "id": "MK09_RAT", "url": "https://www.uniprot.org/uniprot/P49186", "type": "external" } ], "mass": 48017.0, "length": 423, "protein_name": "Mitogen-activated protein kinase 9", "gene_name": "Mapk9", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 9 isoform 2", "refseq_ac": [ { "id": "NP_001257473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257473", "type": "external" } ], "gene_names_uniprotkb": "Mapk9; Jnk2; Prkm9", "gene_names_refseq": "Mapk9; SAPK", "protein_names_uniprotkb": "Mitogen-activated protein kinase 9; 2.7.11.24; MAP kinase 9; MAPK 9; SAPK-alpha; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; p54-alpha", "protein_names_refseq": "MAP kinase 9; MAPK 9; SAPK-alpha; c-Jun N-terminal kinase 2; mitogen-activated protein kinase 9 isoform 2; p54-alpha; stress activated protein kinase alpha II; stress-activated protein kinase JNK2", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:50658); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450321); (R-RNO-450341)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10856240;32414595;33044948;39169203;8177321", "class_list": "", "function": "Chrysophanol Protects Against Acute Heart Failure by Inhibiting JNK1/2 Pathway in Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform-specific functions of c-Jun N-terminal kinase 1 and 2 in lung ischemia-reperfusion injury through the c-Jun/activator protein-1 pathway., [RefSeq, PubMed]; JNK2-MMP-9 axis facilitates the progression of intracranial aneurysms. Erratum:[Sci Rep. 2025 Sep 18;15(1):32593. doi: 10.1038/s41598-025-17846-w. PMID: 40968147] Publication Status: Online-Only, [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (By similarity). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung cancer and prostate cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:1990089 response to nerve growth factor;GO:0007258 JUN phosphorylation;GO:0061833 protein localization to tricellular tight junction;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49186-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2RUW0-1", "uniprot_id": [ { "id": "MROH7_RAT", "url": "https://www.uniprot.org/uniprot/A2RUW0", "type": "external" } ], "mass": 123859.0, "length": 1122, "protein_name": "Maestro heat-like repeat-containing protein family member 7", "gene_name": "Mroh7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mroh7; Heatr8", "gene_names_refseq": "", "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 7; HEAT repeat-containing protein 8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 10, "predicted_n_glycosites": 7, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2RUW0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29995-1", "uniprot_id": [ { "id": "ITPR2_RAT", "url": "https://www.uniprot.org/uniprot/P29995", "type": "external" } ], "mass": 307058.0, "length": 2701, "protein_name": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2", "gene_name": "Itpr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Itpr2", "gene_names_refseq": "", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2; IP3 receptor isoform 2; IP3R 2; Inositol 1,4,5-trisphosphate receptor type 2; InsP3R2; Type 2 InsP3 receptor; Type 2 inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "isolated anhidrosis with normal sweat glands (Disease Ontology:DOID:0060603); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81678); (R-RNO-114508); (R-RNO-139853); (R-RNO-381676); (R-RNO-5578775); (R-RNO-983695)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10620513;11163362;12032348;1655411;22673903;23019322;23884412", "class_list": "", "function": "Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99P56", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005524 ATP binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0030424 axon", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia;GO:0006816 calcium ion transport;GO:0071456 cellular response to hypoxia;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29995-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63722-1", "uniprot_id": [ { "id": "JAG1_RAT", "url": "https://www.uniprot.org/uniprot/Q63722", "type": "external" } ], "mass": 134326.0, "length": 1219, "protein_name": "Protein jagged-1", "gene_name": "Jag1", "organism": "Rat", "refseq_name": "protein jagged-1 precursor", "refseq_ac": [ { "id": "NP_062020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062020", "type": "external" } ], "gene_names_uniprotkb": "Jag1", "gene_names_refseq": "Jag1", "protein_names_uniprotkb": "Protein jagged-1; Jagged1", "protein_names_refseq": "jagged 1; protein jagged-1 precursor; protein jagged-1", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); dilated cardiomyopathy (Disease Ontology:DOID:12930); temporal arteritis (Disease Ontology:DOID:13375); congenital heart disease (Disease Ontology:DOID:1682); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); Alagille syndrome (Disease Ontology:DOID:9245)", "pathway": " (rno:29146); (R-RNO-9013149); (R-RNO-9013423); (R-RNO-9013507)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "28089369;31585906;33049352;34269482;34755661;7697721", "class_list": "", "function": "Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis., [UniProtKB]; Propofol alleviates neuropathic pain in chronic constriction injury rat models via the microRNA-140-3p/Jagged-1 peptide/Notch signaling pathway., [RefSeq, PubMed]; Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1., [RefSeq, PubMed]; TMEM45A is involved in renal fibrosis in rats by regulating Jagged1/Notch pathway. Publication Status: Online-Only, [RefSeq, PubMed]; [Inhibition of the Notch1/Jagged1 pathway promotes homing of bone mesenchymal stem cells to improve asthma in rats]., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "P70640", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0072006 nephron development;GO:0072070 loop of Henle development;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63722-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Q4-1", "uniprot_id": [ { "id": "METH_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Q4", "type": "external" } ], "mass": 139164.0, "length": 1253, "protein_name": "Methionine synthase", "gene_name": "Mtr", "organism": "Rat", "refseq_name": "methionine synthase", "refseq_ac": [ { "id": "NP_110491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110491", "type": "external" } ], "gene_names_uniprotkb": "Mtr", "gene_names_refseq": "Mtr; methioninesynthase", "protein_names_uniprotkb": "Methionine synthase; 2.1.1.13; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; MS; Vitamin-B12 dependent methionine synthase", "protein_names_refseq": "MS; cobalamin-dependent methionine synthase; methionine synthase; vitamin-B12 dependent methionine synthase", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); vitamin B12 deficiency (Disease Ontology:DOID:0050731); methylmalonic aciduria and homocystinuria type cblG (Disease Ontology:DOID:0050733); spina bifida (Disease Ontology:DOID:0080016); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); autistic disorder (Disease Ontology:DOID:12849); pancreatic cancer (Disease Ontology:DOID:1793); IgA glomerulonephritis (Disease Ontology:DOID:2986); cerebral infarction (Disease Ontology:DOID:3526); retinoblastoma (Disease Ontology:DOID:768); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:81522); (R-RNO-156581); (R-RNO-1614635); (R-RNO-9013407); (R-RNO-9759218)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "22673903;25467853;9219091;9972236", "class_list": "", "function": "Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:9219091, PubMed:9972236). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis (PubMed:9219091, PubMed:9972236). Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (By similarity). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The objective of this study was to investigate the effects of dietary Zn supply on homocysteine levels and expression of Methionine synthase and betaine-homocysteine methyltransferase in growing rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.16.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6", "type": "external" }, { "id": "2.5.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.8", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0008705 methionine synthase activity;GO:0008270 zinc ion binding;GO:0016597 amino acid binding;GO:0008168 methyltransferase activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0006479 protein methylation;GO:0046653 tetrahydrofolate metabolic process;GO:0006555 methionine metabolic process;GO:0009086 methionine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2Q4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88989-1", "uniprot_id": [ { "id": "MDHC_RAT", "url": "https://www.uniprot.org/uniprot/O88989", "type": "external" } ], "mass": 36483.0, "length": 334, "protein_name": "Malate dehydrogenase, cytoplasmic", "gene_name": "Mdh1", "organism": "Rat", "refseq_name": "malate dehydrogenase, cytoplasmic isoform Mdh1", "refseq_ac": [ { "id": "NP_150238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150238", "type": "external" } ], "gene_names_uniprotkb": "Mdh1; Mdh", "gene_names_refseq": "KAR; MDL1; Mdh1; Mdhl; Mor2", "protein_names_uniprotkb": "Malate dehydrogenase, cytoplasmic; 1.1.1.37; Aromatic alpha-keto acid reductase; Cytosolic malate dehydrogenase; KAR", "protein_names_refseq": "Malate dehydrogenase-like enzyme; aromatic alpha-keto acid reductase; cytosolic malate dehydrogenase; malate dehydrogenase 1, NAD (soluble); malate dehydrogenase, cytoplasmic isoform Mdh1; malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal; malate dehydrogenase, soluble", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 19 with or without anosmia (Disease Ontology:DOID:0090090); developmental and epileptic encephalopathy 88 (Disease Ontology:DOID:0112222); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:24551); (R-RNO-9856872)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;34502162", "class_list": "", "function": "Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. [provided by RefSeq, Feb 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88585;Q6PCV2", "ec_number_list": [ { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0030060 L-malate dehydrogenase (NAD+) activity;GO:0016615 malate dehydrogenase activity;GO:0047995 (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006107 oxaloacetate metabolic process;GO:0019674 NAD+ metabolic process;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O88989-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10824-1", "uniprot_id": [ { "id": "GNAI1_RAT", "url": "https://www.uniprot.org/uniprot/P10824", "type": "external" } ], "mass": 40345.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "gene_name": "Gnai1", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-1", "refseq_ac": [ { "id": "NP_037277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037277", "type": "external" } ], "gene_names_uniprotkb": "Gnai1; Gnai-1", "gene_names_refseq": "BPGTPB; Gnai1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-1; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "adenylate cyclase-inhibiting G alpha protein; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit", "tax_id": 10116, "disease": "McCune Albright syndrome (Disease Ontology:DOID:1858)", "pathway": " (rno:25686); (R-RNO-170670); (R-RNO-392170); (R-RNO-400042); (R-RNO-418594); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 22, "publication_id_list": "11121039;11387333;16870394;17635935;19211784;19703466;21158412;21653697;24596087;25037222;26253820;26620557;27558716;27936598;2820999;28627018;32103024;8073283;8521505;9108480;9705312;9772163", "class_list": "", "function": "Data suggest that Gnai1 subunit of GTP-binding protein catalyzes nucleotide exchange by selective perturbance of GDP-bound conformation of Gnai1 to metastable intermediate structural state and accelerates rate-limiting step of GDP release by surpassing kinetic barrier., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:19703466, PubMed:24596087, PubMed:25037222). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:19703466, PubMed:24596087, PubMed:25037222). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:19703466, PubMed:24596087, PubMed:25037222). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21158412). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:21158412). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:19703466). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:16870394). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Induction of Galphai1 structural heterogeneity by Ric-8A provides a mechanism for nucleotide release, [RefSeq, PubMed]; Molecular dynamics simulation of a myristoylated G protein subunit alpha i1 (Galphai1)-GTP complex suggests that the myristoyl-induced conformational changes of the switch II and alpha helical domains create new possibilities for protein-protein interactions., [RefSeq, PubMed]; Stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q45QN2", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0051301 cell division;GO:0070098 chemokine-mediated signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P10824-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14942-1", "uniprot_id": [ { "id": "GSTA4_RAT", "url": "https://www.uniprot.org/uniprot/P14942", "type": "external" } ], "mass": 25510.0, "length": 222, "protein_name": "Glutathione S-transferase alpha-4", "gene_name": "Gsta4", "organism": "Rat", "refseq_name": "glutathione S-transferase alpha-4", "refseq_ac": [ { "id": "NP_001100310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100310", "type": "external" } ], "gene_names_uniprotkb": "Gsta4", "gene_names_refseq": "Gsta4", "protein_names_uniprotkb": "Glutathione S-transferase alpha-4; 2.5.1.18; GST 8-8; GST A4-4; GST K; GST Yk; Glutathione S-transferase Yk", "protein_names_refseq": "GST 8-8; GST A4-4; GST K; GST Yk; glutathione S-transferase A4; glutathione S-transferase Yk; glutathione S-transferase alpha-4; glutathione transferase", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:300850)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1599415;22160604;24771067;2775231;32792491", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB]; Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis. Publication Status: Online-Only, [RefSeq, PubMed]; The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs. Erratum:[Mol Cell Biochem. 2019 Sep;459(1-2):215-217. doi: 10.1007/s11010-019-03587-8. PMID: 31325012], [RefSeq, PubMed]; These results showed and mapped naturally occurring genetic differences in the expression of Gsta4 associated both with a highly significant increase in the survival of axotomized motoneurons and with a trans-regulation of several molecular pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0015643 toxic substance binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0010043 response to zinc ion;GO:0035094 response to nicotine;GO:0006805 xenobiotic metabolic process;GO:0061771 response to caloric restriction;GO:0009635 response to herbicide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P14942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46152-1", "uniprot_id": [ { "id": "GATA4_RAT", "url": "https://www.uniprot.org/uniprot/P46152", "type": "external" } ], "mass": 44597.0, "length": 440, "protein_name": "Transcription factor GATA-4", "gene_name": "Gata4", "organism": "Rat", "refseq_name": "transcription factor GATA-4", "refseq_ac": [ { "id": "NP_653331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653331", "type": "external" } ], "gene_names_uniprotkb": "Gata4", "gene_names_refseq": "Gata4", "protein_names_uniprotkb": "Transcription factor GATA-4; DNA-binding protein GATA-GT2; GATA-binding factor 4", "protein_names_refseq": "DNA-binding protein GATA-GT2; GATA-binding factor 4; transcription factor GATA-4", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); atrial heart septal defect 2 (Disease Ontology:DOID:0110107); prostate cancer (Disease Ontology:DOID:10283); protein-losing enteropathy (Disease Ontology:DOID:10611); breast cancer (Disease Ontology:DOID:1612); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); atrial heart septal defect (Disease Ontology:DOID:1882); endometrial adenocarcinoma (Disease Ontology:DOID:2870); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); cervical cancer (Disease Ontology:DOID:4362); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (rno:54254); (R-RNO-983231)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "15329343;16166646;20874724;21702924;22674427;29545582;32060996;35217336;35286985;36279967;36694058;36814152;37712274;8248184", "class_list": "", "function": "Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Abeta1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis., [RefSeq, PubMed]; GATA4 promotes the senescence of nucleus pulposus cells via NF-kappaB pathway., [RefSeq, PubMed]; LncRNA KCNQ1OT1 attenuates myocardial injury induced by hip fracture via regulating of miR-224-3p/GATA4 axis., [RefSeq, PubMed]; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0061026 cardiac muscle tissue regeneration;GO:0003290 atrial septum secundum morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84245-1", "uniprot_id": [ { "id": "H33_RAT", "url": "https://www.uniprot.org/uniprot/P84245", "type": "external" } ], "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3", "gene_name": "H3-3b", "organism": "Rat", "refseq_name": "histone H3.3", "refseq_ac": [ { "id": "NP_446437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446437", "type": "external" } ], "gene_names_uniprotkb": "H3-3b; H3.3b; H3f3b", "gene_names_refseq": "H3-3b; H3.3B; H3f3b", "protein_names_uniprotkb": "Histone H3.3", "protein_names_refseq": "H3 histone family member 3B; H3 histone, family 3B; histone H3.3", "tax_id": 10116, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012); diffuse midline glioma, H3 K27-altered (Disease Ontology:DOID:0080684)", "pathway": " (rno:117056); (R-RNO-212300); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-983231); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 24, "publication_count": 7, "publication_id_list": "12560483;19343714;24747049;32273471;38843836;7877725;9582357", "class_list": "", "function": "Data indicate that histone demethylases KDM4A/C regulate H3K9 and H3K36 methylation on brain-derived neurotrophic factor (BDNF) versus astroglial glial fibrillary acidic protein (GFAP) genes in neural stem cells., [RefSeq, PubMed]; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P06351;P33155;Q5RJM5;Q9V3W4", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0032991 protein-containing complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0030307 positive regulation of cell growth;GO:0006334 nucleosome assembly;GO:0009725 response to hormone;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P84245-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3LUD3-1", "uniprot_id": [ { "id": "N4BP3_RAT", "url": "https://www.uniprot.org/uniprot/Q3LUD3", "type": "external" } ], "mass": 60048.0, "length": 537, "protein_name": "Nedd4 binding protein 3", "gene_name": "N4bp3", "organism": "Rat", "refseq_name": "nedd4 binding protein 3", "refseq_ac": [ { "id": "NP_001029065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029065", "type": "external" } ], "gene_names_uniprotkb": "N4bp3", "gene_names_refseq": "C330016o10rik; N4bp3; RGD1308356", "protein_names_uniprotkb": "Nedd4 binding protein 3; N4BP3", "protein_names_refseq": "NEDD4-binding protein 3; nedd4 binding protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:303112)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16522626;24044555", "class_list": "", "function": "N4BP3 is a molecular element for the correct branching of neurites in developing neurons with a central role for an N4BP3-Nedd4 complex in neurite branching and circuit formation. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2 (By similarity). Also plays a role in axon and dendrite arborization during cranial nerve development (PubMed:24044555). May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (PubMed:24044555)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3LUD3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G008-1", "uniprot_id": [ { "id": "K0930_RAT", "url": "https://www.uniprot.org/uniprot/Q4G008", "type": "external" } ], "mass": 45958.0, "length": 404, "protein_name": "Uncharacterized protein KIAA0930 homolog", "gene_name": "Kiaa0930", "organism": "Rat", "refseq_name": "uncharacterized protein KIAA0930 homolog", "refseq_ac": [ { "id": "NP_001257976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257976", "type": "external" } ], "gene_names_uniprotkb": "Kiaa0930; RGD1304694", "gene_names_refseq": "Kiaa0930; RGD1304694", "protein_names_uniprotkb": "Uncharacterized protein KIAA0930 homolog", "protein_names_refseq": "uncharacterized protein KIAA0930 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362974)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G008-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB94-1", "uniprot_id": [ { "id": "MYZAP_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB94", "type": "external" } ], "mass": 53955.0, "length": 466, "protein_name": "Myocardial zonula adherens protein", "gene_name": "Myzap", "organism": "Rat", "refseq_name": "myocardial zonula adherens protein precursor", "refseq_ac": [ { "id": "NP_001014233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014233", "type": "external" } ], "gene_names_uniprotkb": "Myzap; Myozap", "gene_names_refseq": "Gcom1; Myzap", "protein_names_uniprotkb": "Myocardial zonula adherens protein", "protein_names_refseq": "GRINL1A combined protein; GRINL1A complex locus 1; GRINL1A complex locus protein 1; myocardial zonula adherens protein precursor; myozap", "tax_id": 10116, "disease": "", "pathway": " (rno:363091)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18849881;20093627;29445566;31384490", "class_list": "", "function": "Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0031674 I band;GO:0009898 cytoplasmic side of plasma membrane;GO:0030018 Z disc;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5EB94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63279-1", "uniprot_id": [ { "id": "K1C19_RAT", "url": "https://www.uniprot.org/uniprot/Q63279", "type": "external" } ], "mass": 44636.0, "length": 403, "protein_name": "Keratin, type I cytoskeletal 19", "gene_name": "Krt19", "organism": "Rat", "refseq_name": "keratin, type I cytoskeletal 19", "refseq_ac": [ { "id": "NP_955792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955792", "type": "external" } ], "gene_names_uniprotkb": "Krt19; Ka19; Krt1-19", "gene_names_refseq": "Ka19; Krt1-19; Krt19", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 19; CK-19; Cytokeratin-19; K19; Keratin-19; Type I keratin Ka19", "protein_names_refseq": "CK-19; K19; cytokeratin 19; keratin 19, type I; keratin complex 1, acidic, gene 19; keratin, type I cytoskeletal 19; type I keratin KA19", "tax_id": 10116, "disease": "", "pathway": " (rno:360626); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15085952;15247274;22673903;8541209", "class_list": "", "function": "Cytokeratins 8 and 19 are expressed in adult striated muscle, where they may contribute to the organization of both the myoplasm and sarcolemma, [RefSeq, PubMed]; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN08;Q5M7V2;Q6S6J4;Q9Z253", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008307 structural constituent of muscle;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0042383 sarcolemma", "go_biological_process": "GO:0060706 cell differentiation involved in embryonic placenta development;GO:0007219 Notch signaling pathway;GO:0030855 epithelial cell differentiation;GO:0043627 response to estrogen;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63279-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63772-1", "uniprot_id": [ { "id": "GAS6_RAT", "url": "https://www.uniprot.org/uniprot/Q63772", "type": "external" } ], "mass": 74638.0, "length": 674, "protein_name": "Growth arrest-specific protein 6", "gene_name": "Gas6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gas6", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth arrest-specific protein 6; AXL receptor tyrosine kinase ligand; GAS-6; GPF; Growth-potentiating factor", "protein_names_refseq": "", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); glomerulonephritis (Disease Ontology:DOID:2921)", "pathway": " (R-RNO-114608); (R-RNO-159763); (R-RNO-159782); (R-RNO-202733); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16641100;7559388;7890695;8939948;9163328", "class_list": "", "function": "Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0005509 calcium ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0071307 cellular response to vitamin K;GO:0085029 extracellular matrix assembly;GO:0097241 hematopoietic stem cell migration to bone marrow", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63772-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES71-1", "uniprot_id": [ { "id": "GNPAT_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES71", "type": "external" } ], "mass": 77076.0, "length": 678, "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "Gnpat", "organism": "Rat", "refseq_name": "dihydroxyacetone phosphate acyltransferase", "refseq_ac": [ { "id": "NP_445862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445862", "type": "external" } ], "gene_names_uniprotkb": "Gnpat", "gene_names_refseq": "Gnpat", "protein_names_uniprotkb": "Dihydroxyacetone phosphate acyltransferase; 2.3.1.42; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; DAP-AT; DHAP-AT; Glycerone-phosphate O-acyltransferase", "protein_names_refseq": "DAP-AT; DHAP-AT; acyl-CoA:dihydroxyacetonephosphate acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase; dihydroxyacetone phosphate acyltransferase; glycerone-phosphate O-acyltransferase", "tax_id": 10116, "disease": "rhizomelic chondrodysplasia punctata type 2 (Disease Ontology:DOID:0110852); disease of mental health (Disease Ontology:DOID:150)", "pathway": " (rno:84470); (R-RNO-1483166); (R-RNO-75896); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;29393594;9459311", "class_list": "", "function": "Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0007584 response to nutrient;GO:0008611 ether lipid biosynthetic process;GO:0042594 response to starvation;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ES71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70511-1", "uniprot_id": [ { "id": "ANK3_RAT", "url": "https://www.uniprot.org/uniprot/O70511", "type": "external" } ], "mass": 284443.0, "length": 2622, "protein_name": "Ankyrin-3", "gene_name": "Ank3", "organism": "Rat", "refseq_name": "ankyrin-3 isoform 2", "refseq_ac": [ { "id": "NP_001029156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029156", "type": "external" } ], "gene_names_uniprotkb": "Ank3", "gene_names_refseq": "ANK-3; Ank3", "protein_names_uniprotkb": "Ankyrin-3; ANK-3; Ankyrin-G", "protein_names_refseq": "ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, node of Ranvier (ankyrin G); ankyrin-3 isoform 2; ankyrin-G", "tax_id": 10116, "disease": "alcohol-related birth defects (Disease Ontology:DOID:0050668); autosomal recessive intellectual developmental disorder 37 (Disease Ontology:DOID:0081202); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); post-traumatic stress disorder (Disease Ontology:DOID:2055); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:361833)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11796721;15579534;15953600;18683930;21223964;21617128;22673903;28657654;31934859;36083912;38843836;9744885", "class_list": "", "function": "Ankyrin-G mediates targeting of both Na(+) and KATP channels to the rat cardiac intercalated disc. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (PubMed:21617128)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q574D7;Q574D8;Q574D9;Q574E0;Q574E2;Q8VDA0", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0030674 protein-macromolecule adaptor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0032507 maintenance of protein location in cell;GO:0045806 negative regulation of endocytosis;GO:0099612 protein localization to axon;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007009 plasma membrane organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O70511-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46933-1", "uniprot_id": [ { "id": "APBB1_RAT", "url": "https://www.uniprot.org/uniprot/P46933", "type": "external" } ], "mass": 77656.0, "length": 711, "protein_name": "Amyloid beta precursor protein binding family B member 1", "gene_name": "Apbb1", "organism": "Rat", "refseq_name": "amyloid beta precursor protein binding family B member 1 isoform 1", "refseq_ac": [ { "id": "NP_536726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536726", "type": "external" } ], "gene_names_uniprotkb": "Apbb1; Fe65; Rir", "gene_names_refseq": "Apbb1; FE65", "protein_names_uniprotkb": "Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Protein Fe65", "protein_names_refseq": "amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding family B member 1; amyloid beta precursor protein binding family B member 1 isoform 1", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:29722); (R-RNO-5693565)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "18304449;1923810;19282473;19343227;22429478;23531501;7800475", "class_list": "", "function": "Fe65 is the bridging protein to amyloid-beta protein precursor in the complex formed and thus we simultaneously describe another PP1 binding protein, [RefSeq, PubMed]; Our data suggest that FE65 serves as a link between VLDLR and APP Publication Status: Online-Only, [RefSeq, PubMed]; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:19282473). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Plays a role in the maintenance of lens transparency. May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99MK3", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006939 smooth muscle contraction;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P46933-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47863-1", "uniprot_id": [ { "id": "AQP4_RAT", "url": "https://www.uniprot.org/uniprot/P47863", "type": "external" } ], "mass": 34480.0, "length": 323, "protein_name": "Aquaporin-4", "gene_name": "Aqp4", "organism": "Rat", "refseq_name": "aquaporin-4 isoform M23", "refseq_ac": [ { "id": "NP_001135838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135838", "type": "external" } ], "gene_names_uniprotkb": "Aqp4", "gene_names_refseq": "AQP-4; Aqp4; Miwc; WCH4", "protein_names_uniprotkb": "Aquaporin-4; AQP-4; MIWC; Mercurial-insensitive water channel; WCH4", "protein_names_refseq": "aquaporin-4 isoform M23; mercurial-insensitive water channel", "tax_id": 10116, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); uveitis (Disease Ontology:DOID:13141); blindness (Disease Ontology:DOID:1432); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); thymoma (Disease Ontology:DOID:3275); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); central pontine myelinolysis (Disease Ontology:DOID:636); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); diabetes mellitus (Disease Ontology:DOID:9351); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (rno:25293); (R-RNO-432040); (R-RNO-432047)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "12359252;12692561;16325200;16641100;18179769;18255256;19406128;19800950;21621589;21850708;22673903;23616425;29055082;38735619;38785370;7509789;7528931", "class_list": "", "function": "AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4., [RefSeq, PubMed]; Forms a water-specific channel (PubMed:19800950, PubMed:7509789, PubMed:7528931). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identified all functional AQP4 isoforms -M1, M23, and Mz- and the formation of higher-order complexes in the organ of Corti of the rat., [RefSeq, PubMed]; Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression and astrocyte swelling following cerebral ischemia/reperfusion injury., [RefSeq, PubMed]; Rat AQP4 has six cDNA isoforms, formed by alternative splicing. These are named AQP4a-f, where AQP4a and AQP4c correspond to the two classical M1 and M23 isoforms, respectively, [RefSeq, PubMed]; This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]., [RefSeq]; When transfected in Hela cells, the longer rat AQP4 isoform, not present in humans, impairs formation of the orthogonal array of particles in astrocyte primary cultures., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K4I1;Q8CIY8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015267 channel activity;GO:0005372 water transmembrane transporter activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0051289 protein homotetramerization;GO:0071333 cellular response to glucose stimulus;GO:0032691 negative regulation of interleukin-1 beta production;GO:0032715 negative regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P47863-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58197-1", "uniprot_id": [ { "id": "AP2A_RAT", "url": "https://www.uniprot.org/uniprot/P58197", "type": "external" } ], "mass": 47947.0, "length": 437, "protein_name": "Transcription factor AP-2-alpha", "gene_name": "Tfap2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tfap2a; Tcfap2a", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor AP-2-alpha; AP-2 transcription factor; AP-2; AP2-alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); branchiooculofacial syndrome (Disease Ontology:DOID:0050691); dilated cardiomyopathy (Disease Ontology:DOID:12930); sleep disorder (Disease Ontology:DOID:535)", "pathway": " (rno:306862); (R-RNO-8864260); (R-RNO-8866904); (R-RNO-8866907); (R-RNO-8869496); (R-RNO-9834899)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "10847586;11205881", "class_list": "", "function": "Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18 and C/EBP alpha. Is involved in the negative regulation of Wnt canonical signaling, and is a transcriptional repressor of MYC (By similarity). AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0010172 embryonic body morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58197-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12392-1", "uniprot_id": [ { "id": "ACHB4_RAT", "url": "https://www.uniprot.org/uniprot/P12392", "type": "external" } ], "mass": 55861.0, "length": 495, "protein_name": "Neuronal acetylcholine receptor subunit beta-4", "gene_name": "Chrnb4", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit beta-4 precursor", "refseq_ac": [ { "id": "NP_434693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434693", "type": "external" } ], "gene_names_uniprotkb": "Chrnb4; Acrb4", "gene_names_refseq": "Chrnb4", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-4; N-alpha 2; Neuronal acetylcholine receptor non-alpha-2 chain", "protein_names_refseq": "Acetylcholine receptor beta 4; N-alpha 2; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; neuronal acetylcholine receptor non-alpha-2 chain; neuronal acetylcholine receptor subunit beta-4 precursor; neuronal acetylcholine receptor subunit beta-4; nicotinic acetylcholine receptor-related protein", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324); depressive disorder (Disease Ontology:DOID:1596); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); cocaine abuse (Disease Ontology:DOID:809); oral cavity cancer (Disease Ontology:DOID:8618)", "pathway": " (rno:25103); (R-RNO-629587); (R-RNO-629594); (R-RNO-629597); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10465681;1689727;16964981;25453771;2642007;2918319", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 or CHRNA3:CHRNA5:CHRNB4 play also an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (PubMed:10465681). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Results suggest the fast nAChR current in cutaneous dorsal root ganglia neurons was carried by homomeric alpha7 nAChRs while the slow current was carried by heteromeric (most likely alpha3beta4) nAChRs, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q63361", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030054 cell junction;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12392-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07150-1", "uniprot_id": [ { "id": "ANXA1_RAT", "url": "https://www.uniprot.org/uniprot/P07150", "type": "external" } ], "mass": 38829.0, "length": 346, "protein_name": "Annexin A1", "gene_name": "Anxa1", "organism": "Rat", "refseq_name": "annexin A1", "refseq_ac": [ { "id": "NP_037036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037036", "type": "external" } ], "gene_names_uniprotkb": "Anxa1; Anx1", "gene_names_refseq": "Anx1; Anxa1; p35", "protein_names_uniprotkb": "Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35", "protein_names_refseq": "Annexin 1 (p35) (Lipocortin 1); annexin A1; annexin I; annexin-1; calpactin II; calpactin-2; chromobindin-9; lipocortin 1; lipocortin I; phospholipase A2 inhibitory protein", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); dry eye syndrome (Disease Ontology:DOID:10140); pleurisy (Disease Ontology:DOID:10247); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); uveitis (Disease Ontology:DOID:13141); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); hypothyroidism (Disease Ontology:DOID:1459); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); keratosis follicularis (Disease Ontology:DOID:2734); invasive ductal carcinoma (Disease Ontology:DOID:3008); acute kidney failure (Disease Ontology:DOID:3021); malignant astrocytoma (Disease Ontology:DOID:3069); ischemia (Disease Ontology:DOID:326); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); renal cell carcinoma (Disease Ontology:DOID:4450); seborrheic keratosis (Disease Ontology:DOID:6498); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:25380); (R-RNO-416476); (R-RNO-418594); (R-RNO-444473)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "12467520;1832554;18641677;21454685;22673903;2457028;27634935;29393594;2958780;2969352;3020049;34951334;35896374;36269280;36279933;38526918", "class_list": "", "function": "Annexin A1 conveys neuroprotective function via inhibiting oxidative stress in diffuse axonal injury of rats., [RefSeq, PubMed]; Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage., [RefSeq, PubMed]; Changes in the expression of annexin A1 in the anterior pituitary gland after ovariectomy in rats., [RefSeq, PubMed]; Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation., [RefSeq, PubMed]; Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells. Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:3020049). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). In the context of antitumor immunity, interacts with FPR1 on dendritic cells allowing for tumor-associated antigens uptake and cross-presentation to T cells to mount an antitumor specific T cell response., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; The role of annexin A1 peptide in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64664", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0006954 inflammatory response;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P07150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZM5-1", "uniprot_id": [ { "id": "ABI1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZM5", "type": "external" } ], "mass": 51705.0, "length": 476, "protein_name": "Abl interactor 1", "gene_name": "Abi1", "organism": "Rat", "refseq_name": "abl interactor 1 isoform X2", "refseq_ac": [ { "id": "XP_006254416", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254416", "type": "external" } ], "gene_names_uniprotkb": "Abi1", "gene_names_refseq": "Abi1; E3b1", "protein_names_uniprotkb": "Abl interactor 1; Abelson interactor 1; Abi-1; Eps8 SH3 domain-binding protein; Eps8-binding protein; e3B1", "protein_names_refseq": "abl interactor 1 isoform X2", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-2029482); (R-RNO-4420097); (R-RNO-5663213); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10995551;17304222;22673903;22993434", "class_list": "", "function": "May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030296 protein tyrosine kinase activator activity;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030027 lamellipodium", "go_biological_process": "GO:0061098 positive regulation of protein tyrosine kinase activity;GO:0001764 neuron migration;GO:0001756 somitogenesis;GO:0035855 megakaryocyte development;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZM5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUI5-1", "uniprot_id": [ { "id": "COBL_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUI5", "type": "external" } ], "mass": 122267.0, "length": 1133, "protein_name": "Protein cordon-bleu", "gene_name": "Cobl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cobl", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein cordon-bleu", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:305497)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "21725280;22673903;23223303;29393594", "class_list": "", "function": "Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates dendrite branching in Purkinje cells (By similarity). Regulates neuron morphogenesis and increases branching of axons and dendrites., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0000578 embryonic axis specification;GO:0001889 liver development;GO:0048669 collateral sprouting in absence of injury;GO:0030036 actin cytoskeleton organization;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZUI5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10759-1", "uniprot_id": [ { "id": "AMPD1_RAT", "url": "https://www.uniprot.org/uniprot/P10759", "type": "external" } ], "mass": 86432.0, "length": 747, "protein_name": "AMP deaminase 1", "gene_name": "Ampd1", "organism": "Rat", "refseq_name": "AMP deaminase 1", "refseq_ac": [ { "id": "NP_620231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620231", "type": "external" } ], "gene_names_uniprotkb": "Ampd1", "gene_names_refseq": "Ampd01; Ampd1; RATAMPD01", "protein_names_uniprotkb": "AMP deaminase 1; 3.5.4.6; AMP deaminase isoform M; Myoadenylate deaminase", "protein_names_refseq": "AMP deaminase 1; Ampd; adenosine monophosphate deaminase 1 (isoform M); myoadenylate deaminase", "tax_id": 10116, "disease": "left ventricular failure (Disease Ontology:DOID:0051064); pontocerebellar hypoplasia (Disease Ontology:DOID:0060264); coronary artery disease (Disease Ontology:DOID:3393); lung adenocarcinoma (Disease Ontology:DOID:3910); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25028); (R-RNO-74217)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11102975;22673903;2398891;31880188;3624265;36815317;9133604", "class_list": "", "function": "AMP deaminase plays a critical role in energy metabolism., [UniProtKB, PubMed, PubMed]; Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca[2+] overload in type 2 diabetes rat hearts., [RefSeq, PubMed]; Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P78501;Q6LDJ4", "ec_number_list": [ { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003876 AMP deaminase activity;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046033 AMP metabolic process;GO:0006188 IMP biosynthetic process;GO:0032264 IMP salvage;GO:0033198 response to ATP;GO:0032263 GMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P10759-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1P2-1", "uniprot_id": [ { "id": "ACTN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1P2", "type": "external" } ], "mass": 102960.0, "length": 892, "protein_name": "Alpha-actinin-1", "gene_name": "Actn1", "organism": "Rat", "refseq_name": "alpha-actinin-1", "refseq_ac": [ { "id": "NP_112267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112267", "type": "external" } ], "gene_names_uniprotkb": "Actn1", "gene_names_refseq": "Actn1", "protein_names_uniprotkb": "Alpha-actinin-1; Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin-1; cytoskeletal protein; non-muscle alpha-actinin-1", "tax_id": 10116, "disease": "platelet-type bleeding disorder 15 (Disease Ontology:DOID:0111053); focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128)", "pathway": " (rno:81634); (R-RNO-114608); (R-RNO-446388); (R-RNO-9013418); (R-RNO-9035034)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "14729062;15505042;16464232;21210813;22659164;22673903;24780915;30039887", "class_list": "", "function": "After 6 hours of antiorthostatic suspension alpha-actinin 1 and alpha-actinin 4 levels decreased in the membranous fraction of proteins of cardiomyocytes and soleus muscle fibers. Publication Status: Online-Only, [RefSeq, PubMed]; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation., [UniProtKB, UniProtKB]; That a mechanism by which Hippo pathway and F-actin synergize to modulate YAP activation and localization in the context of intervertebral disc degeneration and help to control nucleus pulposus cells proliferation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0048041 focal adhesion assembly;GO:0030220 platelet formation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9Z1P2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LRS8-1", "uniprot_id": [ { "id": "CD2AP_RAT", "url": "https://www.uniprot.org/uniprot/F1LRS8", "type": "external" } ], "mass": 70491.0, "length": 637, "protein_name": "CD2-associated protein", "gene_name": "Cd2ap", "organism": "Rat", "refseq_name": "CD2-associated protein", "refseq_ac": [ { "id": "NP_852140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852140", "type": "external" } ], "gene_names_uniprotkb": "Cd2ap", "gene_names_refseq": "CMS; Cd2ap", "protein_names_uniprotkb": "CD2-associated protein", "protein_names_refseq": "CD2-associated protein", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis 3 (Disease Ontology:DOID:0112245); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); tauopathy (Disease Ontology:DOID:680); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:316258)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15001553;15910750;18753381;22673903;27076424;29393594;35172672", "class_list": "", "function": "CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting, [RefSeq, PubMed]; Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis., [RefSeq, PubMed]; It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium., [RefSeq, PubMed]; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (PubMed:18753381). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The c-Cbl/CD2AP complex binds to activated Flt-1 and plays a crucial role in its endocytosis and subsequent degradation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TSS5", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0001889 liver development;GO:0006468 protein phosphorylation;GO:0006629 lipid metabolic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F1LRS8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09483-1", "uniprot_id": [ { "id": "ACHA4_RAT", "url": "https://www.uniprot.org/uniprot/P09483", "type": "external" } ], "mass": 70193.0, "length": 630, "protein_name": "Neuronal acetylcholine receptor subunit alpha-4", "gene_name": "Chrna4", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-4 precursor", "refseq_ac": [ { "id": "NP_077330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077330", "type": "external" } ], "gene_names_uniprotkb": "Chrna4; Acra4", "gene_names_refseq": "Chrna4; NARAC", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-4", "protein_names_refseq": "Neuronal nicotinic acetylcholine receptor alpha 4 subunit; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal acetylcholine receptor subunit alpha-4 precursor; neuronal acetylcholine receptor subunit alpha-4", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autosomal dominant nocturnal frontal lobe epilepsy 1 (Disease Ontology:DOID:0060682); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); alcohol use disorder (Disease Ontology:DOID:1574); congenital myasthenic syndrome (Disease Ontology:DOID:3635); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25590); (R-RNO-629587); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "15929983;22593584;22673903;22751014;31901135;33092257;34052301;3609304;37495067;3829125;9882698", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system (By similarity). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (By similarity). Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Decreased expression of Chrna4 by METTL3-mediated m6A modification participates in BPA-induced spatial memory deficit., [RefSeq, PubMed]; Hippocampal asymmetry and regional dispersal of nAChRs alpha4 and alpha7 subtypes in the adult rat., [RefSeq, PubMed]; Lovastatin Differentially Regulates alpha7 and alpha4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant alpha4 subunit of nicotinic ACh receptor., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O35769", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P09483-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVT0-1", "uniprot_id": [ { "id": "AGRF5_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVT0", "type": "external" } ], "mass": 149446.0, "length": 1349, "protein_name": "Adhesion G protein-coupled receptor F5", "gene_name": "Adgrf5", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor F5 precursor", "refseq_ac": [ { "id": "NP_620810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620810", "type": "external" } ], "gene_names_uniprotkb": "Adgrf5; Gpr116; Gprhep", "gene_names_refseq": "Adgrf5; Gpr116; Gprhep; Ig-Hepta", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor F5; G protein-coupled hepta-helical receptor Ig-hepta; G protein-coupled receptor 116; Ig-Hepta", "protein_names_refseq": "G protein-coupled hepta-helical receptor Ig-Hepta; G-protein coupled hepta-helical receptor Ig-hepta; adhesion G protein-coupled receptor F5 precursor; probable G-protein coupled receptor 116", "tax_id": 10116, "disease": "", "pathway": " (rno:245977); (R-RNO-5683826)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10391944;11973329;16641100;16882675;22673903", "class_list": "", "function": "Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump. As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function., [UniProtKB, UniProtKB]", "predicted_glycosites": 21, "predicted_n_glycosites": 20, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043129 surfactant homeostasis;GO:0019216 regulation of lipid metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WVT0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13221-1", "uniprot_id": [ { "id": "AATC_RAT", "url": "https://www.uniprot.org/uniprot/P13221", "type": "external" } ], "mass": 46429.0, "length": 413, "protein_name": "Aspartate aminotransferase, cytoplasmic", "gene_name": "Got1", "organism": "Rat", "refseq_name": "aspartate aminotransferase, cytoplasmic", "refseq_ac": [ { "id": "NP_036703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036703", "type": "external" } ], "gene_names_uniprotkb": "Got1", "gene_names_refseq": "AAT1; ASAT; Aspat; Gaspat; Got1; cAspAT; cCAT", "protein_names_uniprotkb": "Aspartate aminotransferase, cytoplasmic; 2.6.1.1; 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A; cAspAT; cCAT", "protein_names_refseq": "aspartate aminotransferase 1; aspartate aminotransferase, cytoplasmic; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; glutamate oxaloacetate transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble; transaminase A", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); amyloidosis (Disease Ontology:DOID:9120)", "pathway": " (rno:24401); (R-RNO-8963693); (R-RNO-9856872)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "17545671;18683930;21266983;21361730;22673903;2307672;3053674;3182750;3182856;35038133;7113743", "class_list": "", "function": "Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis. Erratum:[Mol Neurobiol. 2022 Aug;59(8):5252. doi: 10.1007/s12035-022-02931-2. PMID: 35727437], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64570;Q6P721", "ec_number_list": [ { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" }, { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609 phosphatidylserine decarboxylase activity;GO:0031406 carboxylic acid binding;GO:0047801 L-cysteine transaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043679 axon terminus", "go_biological_process": "GO:1990267 response to transition metal nanoparticle;GO:0006103 2-oxoglutarate metabolic process;GO:0006533 L-aspartate catabolic process;GO:0006536 glutamate metabolic process;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P13221-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07340-1", "uniprot_id": [ { "id": "AT1B1_RAT", "url": "https://www.uniprot.org/uniprot/P07340", "type": "external" } ], "mass": 35202.0, "length": 304, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1", "gene_name": "Atp1b1", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit beta-1", "refseq_ac": [ { "id": "NP_037245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037245", "type": "external" } ], "gene_names_uniprotkb": "Atp1b1", "gene_names_refseq": "ATPBS; Atp1b1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1", "protein_names_refseq": "ATPase, Na+/K+ transporting, beta 1 polypeptide; Na,K-ATPase beta 1 subunit; sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase subunit beta-1", "tax_id": 10116, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); essential hypertension (Disease Ontology:DOID:10825); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:25650); (R-RNO-210991); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10.1039/D0MO00044B;1314096;14749213;15743908;21454685;22328500;22673903;23532852;24090084;27563007;29802248;3025616;3031033;30746862;33805551;34106099;38843836", "class_list": "", "function": "Data show that Na(+)/K(+)-ATPase's DR-region specific monoclonal antibody and direct activator DRm217 increased Na(+)/K(+)-ATPase activity and alleviated Ca(2+) level., [RefSeq, PubMed]; Decreased content of the glycosylated form of Atp1b1 occurs in the renal tissue of irradiated rats., [RefSeq, PubMed]; Involved in cell adhesion and establishing epithelial cell polarity., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Ngb upregulation in CA1 after hypoxic postconditioning maintained the membranous level of Atp1b1 through Ngb-Atp1b1 interaction. Publication Status: Online-Only, [RefSeq, PubMed]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 8, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 49, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63062", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046982 protein heterodimerization activity;GO:0051117 ATPase binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0045087 innate immune response;GO:0055085 transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 7.0, "record_id": "P07340-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43144-1", "uniprot_id": [ { "id": "ACHA9_RAT", "url": "https://www.uniprot.org/uniprot/P43144", "type": "external" } ], "mass": 54526.0, "length": 479, "protein_name": "Neuronal acetylcholine receptor subunit alpha-9", "gene_name": "Chrna9", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-9 precursor", "refseq_ac": [ { "id": "NP_075219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075219", "type": "external" } ], "gene_names_uniprotkb": "Chrna9; Acra9", "gene_names_refseq": "Chrna9", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-9; NACHR alpha-9; Nicotinic acetylcholine receptor subunit alpha-9", "protein_names_refseq": "NACHR alpha-9; acetylcholine receptor alpha 9 subunit (nAChR); cholinergic receptor, nicotinic, alpha 9 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 9; neuronal acetylcholine receptor subunit alpha-9 precursor; neuronal acetylcholine receptor subunit alpha-9; nicotinic acetylcholine receptor subunit alpha-9", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (rno:65024); (R-RNO-629594)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10713500;11044723;11248107;12117536;12401316;14742688;16306403;18295795;22774872;25740413;28069778;39120784;7954834", "class_list": "", "function": "A two order of magnitude species difference in potency of alpha-conotoxin RgIA is reported for rat versus human alpha9alpha10 nAChR., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:7954834). Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11044723, PubMed:14742688). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:10713500, PubMed:11248107, PubMed:12117536). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (PubMed:11248107). May also regulate keratinocyte adhesion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Key role of the TM2-TM3 loop in calcium potentiation of the alpha9alpha10 nicotinic acetylcholine receptor. Publication Status: Online-Only, [RefSeq, PubMed]; The contribution of subunit interface domains to alpha9alpha10 receptors by a combination of electrophysiological and radioligand binding studies, is reported. Erratum:[Mol Pharmacol. 2017 May;91(5):437. doi: 10.1124/mol.111.107482err. PMID: 28325810], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6PW49", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0022850 serotonin-gated monoatomic cation channel activity;GO:0046872 metal ion binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0043005 neuron projection;GO:0098981 cholinergic synapse", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042391 regulation of membrane potential;GO:0042472 inner ear morphogenesis;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P43144-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69682-1", "uniprot_id": [ { "id": "NECP1_RAT", "url": "https://www.uniprot.org/uniprot/P69682", "type": "external" } ], "mass": 29792.0, "length": 277, "protein_name": "Adaptin ear-binding coat-associated protein 1", "gene_name": "Necap1", "organism": "Rat", "refseq_name": "adaptin ear-binding coat-associated protein 1", "refseq_ac": [ { "id": "NP_001025090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025090", "type": "external" } ], "gene_names_uniprotkb": "Necap1", "gene_names_refseq": "Necap1; RGD1306053", "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1", "protein_names_refseq": "NECAP endocytosis-associated protein 1; NECAP-1; adaptin ear-binding clathrin-associated protein; adaptin ear-binding coat-associated protein 1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 21 (Disease Ontology:DOID:0080443)", "pathway": " (rno:312694); (R-RNO-432722); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "14555962;15292237;16879712;22673903", "class_list": "", "function": "Involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NECAP 1 plays a role in clathrin-mediated neuronal endocytosis, including a role in presynaptic endocytosis. (NECAP 1), [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR67", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0098793 presynapse;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0140238 presynaptic endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P69682-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31388-1", "uniprot_id": [ { "id": "5HT6R_RAT", "url": "https://www.uniprot.org/uniprot/P31388", "type": "external" } ], "mass": 46923.0, "length": 436, "protein_name": "5-hydroxytryptamine receptor 6", "gene_name": "Htr6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Htr6", "gene_names_refseq": "", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; ST-B17; Serotonin receptor 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:64354); (R-RNO-390666)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;7680751;8389146", "class_list": "", "function": "G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7680751). Also has a high affinity for tricyclic psychotropic drugs (PubMed:7680751). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of mTOR signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007612 learning;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0014050 negative regulation of glutamate secretion;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31388-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18163-1", "uniprot_id": [ { "id": "ACSL1_RAT", "url": "https://www.uniprot.org/uniprot/P18163", "type": "external" } ], "mass": 78179.0, "length": 699, "protein_name": "Long-chain-fatty-acid--CoA ligase 1", "gene_name": "Acsl1", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase 1", "refseq_ac": [ { "id": "NP_036952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036952", "type": "external" } ], "gene_names_uniprotkb": "Acsl1; Acs1; Acsl2; Facl2", "gene_names_refseq": "ACS; Acas; Acsl1; COAA; Facl2", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase 1; 6.2.1.15; 6.2.1.24; 6.2.1.3; Arachidonate--CoA ligase; LACS 1; Long-chain acyl-CoA synthetase 1; Long-chain-fatty-acid--CoA ligase, liver isozyme; Phytanate--CoA ligase", "protein_names_refseq": "Acyl CoA synthetase, long chain; LACS 1; arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 2; long-chain acyl-CoA synthetase 1; long-chain-fatty-acid--CoA ligase 1; long-chain-fatty-acid--CoA ligase, liver isozyme; phytanate--CoA ligase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25288); (R-RNO-2046105); (R-RNO-2046106); (R-RNO-75876)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10198260;10749848;15683247;17478130;2341402;24098488;26136511;26446791;27136724;27213235;28209804;33437196;34502162;8973631;8978480", "class_list": "", "function": "Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function, [RefSeq, PubMed]; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Here we revealed that ACSs (Faa1 and Faa4 in yeast and ACSL1, ACSL4, ACSL5, ACSL6, and ACSVL4 in mammals) are involved in LCB uptake. In addition, we provided important insight into the molecular mechanism of LCFA transport Publication Status: Online-Only, [RefSeq, PubMed]; MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity;GO:0003987 acetate-CoA ligase activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P18163-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29419-1", "uniprot_id": [ { "id": "ATP5I_RAT", "url": "https://www.uniprot.org/uniprot/P29419", "type": "external" } ], "mass": 8255.0, "length": 71, "protein_name": "ATP synthase F(0) complex subunit e, mitochondrial", "gene_name": "Atp5me", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit e, mitochondrial", "refseq_ac": [ { "id": "NP_536729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536729", "type": "external" } ], "gene_names_uniprotkb": "Atp5me; Atp5i", "gene_names_refseq": "Atp5i; Atp5k; Atp5me", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase membrane subunit e; ATPase subunit e", "protein_names_refseq": "ATP synthase F(0) complex subunit e, mitochondrial; ATP synthase subunit e, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E; ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E; ATPase subunit e", "tax_id": 10116, "disease": "", "pathway": " (rno:140608); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1429613;1463732;17575325;22673903;26446791;27213235;38320353", "class_list": "", "function": "ATP5me alleviates high glucose-induced myocardial cell injury., [RefSeq, PubMed]; Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P29419-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXQ0-1", "uniprot_id": [ { "id": "ACTN4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXQ0", "type": "external" } ], "mass": 104915.0, "length": 911, "protein_name": "Alpha-actinin-4", "gene_name": "Actn4", "organism": "Rat", "refseq_name": "alpha-actinin-4", "refseq_ac": [ { "id": "NP_113863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113863", "type": "external" } ], "gene_names_uniprotkb": "Actn4", "gene_names_refseq": "Actn4", "protein_names_uniprotkb": "Alpha-actinin-4; Non-muscle alpha-actinin 4", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin-4; non-muscle alpha-actinin 4", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis 1 (Disease Ontology:DOID:0111128); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312)", "pathway": " (rno:63836); (R-RNO-114608)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10673389;15505042;15994232;21933451;26538022;27874083;29393594", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation., [UniProtKB, UniProtKB]; Findings suggest that MICAL-L2 is an effector of insulin-activated Rab13, which links to GLUT4 through ACTN4, localizing GLUT4 vesicles at the muscle cell periphery to enable their fusion with the membrane., [RefSeq, PubMed]; Polyornithine activates alpha-Actinins 4 (ACTN4), which is firstly certified to be expessed in neural stem/progenitor cells, to promote filopodia formation and therefore enhances NSPCs migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P786", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005200 structural constituent of cytoskeleton;GO:0042803 protein homodimerization activity;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QXQ0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62848-1", "uniprot_id": [ { "id": "ARFG1_RAT", "url": "https://www.uniprot.org/uniprot/Q62848", "type": "external" } ], "mass": 45442.0, "length": 415, "protein_name": "ADP-ribosylation factor GTPase-activating protein 1", "gene_name": "Arfgap1; Col20a1", "organism": "Rat", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 1", "refseq_ac": [ { "id": "NP_659558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659558", "type": "external" } ], "gene_names_uniprotkb": "Arfgap1; Col20a1; Arf1gap; Arfgap1; Col20a1", "gene_names_refseq": "Arf GAP1; Arf1gap; Arfgap1", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF GAP 1; ARF1 GAP; ARF1-directed GTPase-activating protein", "protein_names_refseq": "ADP-ribosylation factor 1 GTPase-activating protein; ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase-activating protein 1; ARF GAP 1; ARF1 GAP; ARF1-directed GTPase-activating protein", "tax_id": 10116, "disease": "", "pathway": " (rno:246310); (rno:311716); (R-RNO-1650814); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-8856828); (R-RNO-8948216)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "10102276;11703931;11748249;19015319;20211604;22673903;7890632;8533093;9405360;9733781", "class_list": "", "function": "Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking, [RefSeq, PubMed]; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable collagen protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These findings point to mechanistic differences between ArfGAP1 and the other ArfGAPs known to function in the COPI system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0014069 postsynaptic density;GO:0031965 nuclear membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62848-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP29-1", "uniprot_id": [ { "id": "CALM1_RAT", "url": "https://www.uniprot.org/uniprot/P0DP29", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-1", "gene_name": "Calm1; Calm2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Calm1; Calm2; CaMI; Calm1; Calm2-ps2; Calm3; Calm; Cam1; Cam", "gene_names_refseq": "", "protein_names_uniprotkb": "Calmodulin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); catecholaminergic polymorphic ventricular tachycardia 4 (Disease Ontology:DOID:0060678); long QT syndrome 14 (Disease Ontology:DOID:0110655); Alzheimer's disease (Disease Ontology:DOID:10652); cancer (Disease Ontology:DOID:162); brain infarction (Disease Ontology:DOID:3454); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24242); (rno:24244); (rno:50663)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11323678;12392717;1315919;18056528;201628;22673903;23109337;30021165;3035194;3145979;3990807;8576129", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (By similarity). Calcium-binding is required for the activation of calmodulin (By similarity). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). Is a regulator of voltage-dependent L-type calcium channels (By similarity). Mediates calcium-dependent inactivation of CACNA1C (By similarity). Positively regulates calcium-activated potassium channel activity of KCNN2 (By similarity). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (By similarity). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity). Component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex required to turn off the mitochondrial stress response after a specific stress event has been resolved (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62161;P70667;P99014;Q61379;Q61380", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P0DP29-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U301-1", "uniprot_id": [ { "id": "AKAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U301", "type": "external" } ], "mass": 95941.0, "length": 870, "protein_name": "A-kinase anchor protein 2", "gene_name": "Akap2; Pakap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Akap2; Pakap; Akap2", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchor protein 2; AKAP-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex;GO:0098552 side of membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0008104 intracellular protein localization;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U301-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QA69-1", "uniprot_id": [ { "id": "ABHD5_RAT", "url": "https://www.uniprot.org/uniprot/Q6QA69", "type": "external" } ], "mass": 39104.0, "length": 351, "protein_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5", "gene_name": "Abhd5", "organism": "Rat", "refseq_name": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5", "refseq_ac": [ { "id": "NP_997689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997689", "type": "external" } ], "gene_names_uniprotkb": "Abhd5", "gene_names_refseq": "Abhd5; CGI-58", "protein_names_uniprotkb": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5; 2.3.1.51; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58; Protein CGI-58", "protein_names_refseq": "1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain-containing protein 5; lipid droplet-binding protein CGI-58", "tax_id": 10116, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); autosomal recessive congenital ichthyosis 1 (Disease Ontology:DOID:0060656); colon adenocarcinoma (Disease Ontology:DOID:234); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:316122)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15136565;17308334;22673903;23408028;27590244", "class_list": "", "function": "CGI-58 facilitates lipolysis in cooperation with perilipin and other factors, including lipases, [RefSeq, PubMed]; CGI-58 interacts with perilipin and is localized to lipid droplets, [RefSeq, PubMed]; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In skeletal muscle, during contraction-induced muscle lipolysis, ATGL and CGI-58 strongly associate and that the PLIN proteins work together to regulate lipolysis, [RefSeq, PubMed]; Upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity;GO:0060229 lipase activator activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6QA69-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYA6-1", "uniprot_id": [ { "id": "CYBC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYA6", "type": "external" } ], "mass": 20894.0, "length": 187, "protein_name": "Cytochrome b-245 chaperone 1", "gene_name": "Cybc1", "organism": "Rat", "refseq_name": "cytochrome b-245 chaperone 1", "refseq_ac": [ { "id": "NP_001030131", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030131", "type": "external" } ], "gene_names_uniprotkb": "Cybc1; Eros", "gene_names_refseq": "Cybc1", "protein_names_uniprotkb": "Cytochrome b-245 chaperone 1; Eros; Essential for reactive oxygen species protein", "protein_names_refseq": "cytochrome b-245 chaperone 1; eros; essential for reactive oxygen species protein; uncharacterized protein C17orf62 homolog", "tax_id": 10116, "disease": "autosomal recessive chronic granulomatous disease 5 (Disease Ontology:DOID:0070368)", "pathway": " (rno:619574)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (By similarity). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0045728 respiratory burst after phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYA6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63087-1", "uniprot_id": [ { "id": "ALX1_RAT", "url": "https://www.uniprot.org/uniprot/Q63087", "type": "external" } ], "mass": 36904.0, "length": 326, "protein_name": "ALX homeobox protein 1", "gene_name": "Alx1", "organism": "Rat", "refseq_name": "ALX homeobox protein 1", "refseq_ac": [ { "id": "NP_037053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037053", "type": "external" } ], "gene_names_uniprotkb": "Alx1; Cart1", "gene_names_refseq": "Alx1; CART1X; Cart1", "protein_names_uniprotkb": "ALX homeobox protein 1; CART-1; Cartilage homeoprotein 1", "protein_names_refseq": "ALX homeobox protein 1; CART-1; cartilage homeo protein 1; cartilage homeoprotein 1", "tax_id": 10116, "disease": "frontonasal dysplasia 3 (Disease Ontology:DOID:0081047)", "pathway": " (rno:25401)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12390248;12559496;12929931;7690966", "class_list": "", "function": "P300/CBP stimulate Cart1-dependent transcription activity, and this transactivation is inhibited by E1A and Tax, oncoproteins that suppress the activity of p300/CBP, [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63087-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18910-1", "uniprot_id": [ { "id": "ANPRA_RAT", "url": "https://www.uniprot.org/uniprot/P18910", "type": "external" } ], "mass": 118951.0, "length": 1057, "protein_name": "Atrial natriuretic peptide receptor 1", "gene_name": "Npr1", "organism": "Rat", "refseq_name": "atrial natriuretic peptide receptor 1 precursor", "refseq_ac": [ { "id": "NP_036745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036745", "type": "external" } ], "gene_names_uniprotkb": "Npr1", "gene_names_refseq": "Anpra; Gca; NPR-A; Npr1; Npra", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 1; 4.6.1.2; ANP-A; ANPR-A; Atrial natriuretic peptide receptor type A; GC-A; Guanylate cyclase A; NPR-A", "protein_names_refseq": "ANP-A; ANPR-A; GC-A; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1 precursor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24603); (R-RNO-5578768)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10894551;15117952;1679239;1978722;20977274;2563900;26934489;27283501;28743500;29393594;35534926;38713329;9528788", "class_list": "", "function": "Atenolol treatment normalized the altered expression of Npr1 and Npr2 genes., [RefSeq, PubMed]; Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide., [RefSeq, PubMed]; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Plays an essential role in the regulation of endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro., [RefSeq, PubMed]; The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis., [RefSeq, PubMed]; Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of beta-AR-ROS signaling., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N8", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042562 hormone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0008217 regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P18910-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0T2-1", "uniprot_id": [ { "id": "ANKS6_RAT", "url": "https://www.uniprot.org/uniprot/P0C0T2", "type": "external" } ], "mass": 93809.0, "length": 885, "protein_name": "Ankyrin repeat and SAM domain-containing protein 6", "gene_name": "Anks6", "organism": "Rat", "refseq_name": "ankyrin repeat and SAM domain-containing protein 6", "refseq_ac": [ { "id": "NP_001015028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015028", "type": "external" } ], "gene_names_uniprotkb": "Anks6; Pkdr1; Samd6", "gene_names_refseq": "Anks6; Pkdr1; Samd6", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 6; Polycystic kidney disease protein 1; SAM domain-containing protein 6; SamCystin; Sterile alpha motif domain-containing protein 6", "protein_names_refseq": "SAM domain-containing protein 6; ankyrin repeat and SAM domain-containing protein 6; polycystic kidney disease protein 1; samcystin; sterile alpha motif domain-containing protein 6", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); polycystic kidney disease (Disease Ontology:DOID:0080322); nephrotic syndrome type 10 (Disease Ontology:DOID:0080386); nephronophthisis 16 (Disease Ontology:DOID:0111124); placental insufficiency (Disease Ontology:DOID:3891); uremia (Disease Ontology:DOID:4676); proteinuria (Disease Ontology:DOID:576)", "pathway": " (rno:362515)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16207829;18434273;19324013;23793029;25671767;26188091;26327442", "class_list": "", "function": "Bicc1 and SamCystin interact at the protein level suggesting that they function in a common molecular pathway that when perturbed, is involved in cystogenesis., [RefSeq, PubMed]; Required for renal function., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Susceptibility to renal cyst formation in the (cy/+) rat is caused by a missense mutation in Pkdr1 encoding the novel protein SamCystin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2VWC0;Q5BJL2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097543 ciliary inversin compartment;GO:0005929 cilium", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0045087 innate immune response;GO:0001822 kidney development;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P0C0T2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08722-1", "uniprot_id": [ { "id": "UNC5B_RAT", "url": "https://www.uniprot.org/uniprot/O08722", "type": "external" } ], "mass": 103521.0, "length": 945, "protein_name": "Netrin receptor UNC5B", "gene_name": "Unc5b", "organism": "Rat", "refseq_name": "netrin receptor UNC5B precursor", "refseq_ac": [ { "id": "NP_071543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071543", "type": "external" } ], "gene_names_uniprotkb": "Unc5b; Unc5h2", "gene_names_refseq": "Unc5b; Unc5h2", "protein_names_uniprotkb": "Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B", "protein_names_refseq": "netrin receptor UNC5B precursor; netrin receptor UNC5B; protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc-5 homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60630)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10399920;11387206;15729359;17825258;18582460;19328064;21820492;26116534;27856613;33914819;35668343;9126742", "class_list": "", "function": "Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury. Publication Status: Online-Only, [RefSeq, PubMed]; Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor., [RefSeq, PubMed]; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The Unc5B receptor and subsequent activation of the tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling in the spinal cord., [RefSeq, PubMed]; These data suggest that netrin-1 could be an endogenous trophic factor for Schwann cells in the injured peripheral nerves., [RefSeq, PubMed]; Treadmill exercise has beneficial effects via involvement of netrin-1 and its receptors DCC and Unc5B in neuronal and vascular activities in brain-ischemic rats., [RefSeq, PubMed]; UNC5B Overexpression Alleviates Peripheral Neuropathic Pain by Stimulating Netrin-1-Dependent Autophagic Flux in Schwann Cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006915 apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O08722-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85515-1", "uniprot_id": [ { "id": "ACTZ_RAT", "url": "https://www.uniprot.org/uniprot/P85515", "type": "external" } ], "mass": 42614.0, "length": 376, "protein_name": "Alpha-centractin", "gene_name": "Actr1a", "organism": "Rat", "refseq_name": "alpha-centractin", "refseq_ac": [ { "id": "NP_001099834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099834", "type": "external" } ], "gene_names_uniprotkb": "Actr1a; Ctrn1", "gene_names_refseq": "Actr1a", "protein_names_uniprotkb": "Alpha-centractin; Centractin", "protein_names_refseq": "ARP1 actin related protein 1 homolog A; ARP1 actin-related protein 1 homolog A, centractin alpha; alpha-centractin; centractin", "tax_id": 10116, "disease": "Down syndrome (Disease Ontology:DOID:14250); colon cancer (Disease Ontology:DOID:219)", "pathway": " (rno:294010); (R-RNO-2132295); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-8854518)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "19343716", "class_list": "", "function": "Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005938 cell cortex;GO:0002177 manchette;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P85515-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08081-1", "uniprot_id": [ { "id": "CLCA_RAT", "url": "https://www.uniprot.org/uniprot/P08081", "type": "external" } ], "mass": 26981.0, "length": 248, "protein_name": "Clathrin light chain A", "gene_name": "Clta", "organism": "Rat", "refseq_name": "clathrin light chain A isoform 2", "refseq_ac": [ { "id": "NP_114180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114180", "type": "external" } ], "gene_names_uniprotkb": "Clta", "gene_names_refseq": "Clta; LCA1; LCA2; LCA3", "protein_names_uniprotkb": "Clathrin light chain A; Lca", "protein_names_refseq": "clathrin light chain A isoform 2; clathrin, light chain (Lca); clathrin, light polypeptide (Lca); lca", "tax_id": 10116, "disease": "", "pathway": " (rno:83800); (R-RNO-177504); (R-RNO-190873); (R-RNO-196025); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 14, "publication_count": 3, "publication_id_list": "20231386;22673903;3563513", "class_list": "", "function": "Clathrin is the major protein of the polyhedral coat of coated pits and vesicles., [UniProtKB, UniProtKB, UniProtKB]; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity)., [UniProtKB, UniProtKB]; The results underscore the highly dynamic and cargo-responsive nature of CCP assembly and suggest that the observed heterogeneity is, in part, related to compositional differences (e.g., cargo and adaptors) between CCPs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding;GO:0042277 peptide binding;GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030118 clathrin coat;GO:0030125 clathrin vesicle coat;GO:0098835 presynaptic endocytic zone membrane;GO:0005768 endosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0051301 cell division;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35774-1", "uniprot_id": [ { "id": "AKAP4_RAT", "url": "https://www.uniprot.org/uniprot/O35774", "type": "external" } ], "mass": 93494.0, "length": 847, "protein_name": "A-kinase anchor protein 4", "gene_name": "Akap4", "organism": "Rat", "refseq_name": "A-kinase anchor protein 4 isoform 1", "refseq_ac": [ { "id": "NP_077378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077378", "type": "external" } ], "gene_names_uniprotkb": "Akap4", "gene_names_refseq": "Akap4", "protein_names_uniprotkb": "A-kinase anchor protein 4; 75 kDa fibrous sheath protein; AKAP-4; Major sperm fibrous sheath protein; PRKA4; Protein kinase A-anchoring protein 4", "protein_names_refseq": "75 kDa fibrous sheath protein; A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4 isoform 1; A-kinase anchor protein 4; AKAP-4; PRKA4; major sperm fibrous sheath protein; protein kinase A-anchoring protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:79254)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19423663;22673903", "class_list": "", "function": "Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 30, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0031514 motile cilium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0045184 establishment of protein localization;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35774-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63014-1", "uniprot_id": [ { "id": "AKAP8_RAT", "url": "https://www.uniprot.org/uniprot/Q63014", "type": "external" } ], "mass": 76162.0, "length": 687, "protein_name": "A-kinase anchor protein 8", "gene_name": "Akap8", "organism": "Rat", "refseq_name": "A-kinase anchor protein 8", "refseq_ac": [ { "id": "NP_446307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446307", "type": "external" } ], "gene_names_uniprotkb": "Akap8; Akap95", "gene_names_refseq": "Akap8; Akap95", "protein_names_uniprotkb": "A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AKAP 95; AKAP-8", "protein_names_refseq": "A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AKAP 95; AKAP-8", "tax_id": 10116, "disease": "", "pathway": " (rno:116633)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11279182;15878851;16721056;22130794;22673903;29393594;33716104;8125992", "class_list": "", "function": "Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:8125992). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Lactate dehydrogenase subunit A mRNA stability is regulated by Cyclic AMP and AKAP-mediated targeting of protein kinase A, [RefSeq, PubMed]; New insights into how AKAP95 orchestrates cell cycle progression., [RefSeq, PubMed]; Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0045087 innate immune response;GO:0032720 negative regulation of tumor necrosis factor production;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q63014-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06686-1", "uniprot_id": [ { "id": "AT1A2_RAT", "url": "https://www.uniprot.org/uniprot/P06686", "type": "external" } ], "mass": 112217.0, "length": 1020, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-2", "gene_name": "Atp1a2", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_036637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036637", "type": "external" } ], "gene_names_uniprotkb": "Atp1a2", "gene_names_refseq": "Atp1a2; RATATPA2", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-2; 7.2.2.13; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; sodium pump subunit alpha-2; sodium/potassium-transporting ATPase subunit alpha-2 precursor; sodium/potassium-transporting ATPase subunit alpha-2", "tax_id": 10116, "disease": "alternating hemiplegia of childhood (Disease Ontology:DOID:0050635); familial hemiplegic migraine (Disease Ontology:DOID:0060178); developmental and epileptic encephalopathy 98 (Disease Ontology:DOID:0070384); familial hemiplegic migraine 2 (Disease Ontology:DOID:0111182); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); migraine with aura (Disease Ontology:DOID:10024); hypertension (Disease Ontology:DOID:10763); benign neonatal seizures (Disease Ontology:DOID:14264); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:24212); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1846906;2170235;22673903;23532852;29118027;29394489;29480968;3028470;30949686;38843836", "class_list": "", "function": "Cardiomyocyte ATP1A2 is a target of A/R injury, [RefSeq, PubMed]; Catalytic subunit of the Na(+)/K(+)-ATPase that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle (By similarity). It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes., [RefSeq, PubMed]; Report structural requirements for the Na-K-ATPase to function as a Src-dependent receptor and provide strong evidence of isoform-specific Src interaction involving the identified key amino acids., [RefSeq, PubMed]; The alpha2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca(2+) sensitization. Erratum:[Acta Physiol (Oxf). 2019 Sep;227(1):e13343. doi: 10.1111/apha.13343. PMID: 31402596], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0008344 adult locomotory behavior;GO:0008542 visual learning;GO:0035094 response to nicotine;GO:0002087 regulation of respiratory gaseous exchange by nervous system process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P06686-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16638-1", "uniprot_id": [ { "id": "ACLY_RAT", "url": "https://www.uniprot.org/uniprot/P16638", "type": "external" } ], "mass": 120636.0, "length": 1100, "protein_name": "ATP-citrate synthase", "gene_name": "Acly", "organism": "Rat", "refseq_name": "ATP-citrate synthase isoform 2", "refseq_ac": [ { "id": "NP_001104565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104565", "type": "external" } ], "gene_names_uniprotkb": "Acly", "gene_names_refseq": "ACL; Acly; Clatp", "protein_names_uniprotkb": "ATP-citrate synthase; 2.3.3.8; ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme", "protein_names_refseq": "ATP-citrate (pro-S-)-lyase; ATP-citrate synthase isoform 2; ATP-citrate synthase; citrate cleavage enzyme", "tax_id": 10116, "disease": "", "pathway": " (rno:24159); (R-RNO-6798695); (R-RNO-75105)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12107176;16396499;21454710;2176822;22673903;2295639;23225248;29779826;34502162;8688462;9116495", "class_list": "", "function": "ATP citrate lyase is important for the pyruvate citrate shuttle and lipid synthesis in insulin secretion., [RefSeq, PubMed]; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q497C7;Q8VIQ1", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003878 ATP citrate synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006101 citrate metabolic process;GO:0008610 lipid biosynthetic process;GO:0006084 acetyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P16638-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26769-1", "uniprot_id": [ { "id": "ADCY2_RAT", "url": "https://www.uniprot.org/uniprot/P26769", "type": "external" } ], "mass": 123316.0, "length": 1090, "protein_name": "Adenylate cyclase type 2", "gene_name": "Adcy2", "organism": "Rat", "refseq_name": "adenylate cyclase type 2", "refseq_ac": [ { "id": "NP_112269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112269", "type": "external" } ], "gene_names_uniprotkb": "Adcy2", "gene_names_refseq": "AC2; Adcy2", "protein_names_uniprotkb": "Adenylate cyclase type 2; 4.6.1.1; AC2; ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2", "protein_names_refseq": "ATP pyrophosphate-lyase 2; adenylate cyclase 2 (brain); adenylate cyclase type 2; adenylate cyclase type II; adenylyl cyclase 2", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312)", "pathway": " (rno:81636); (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10427002;11087399;15591060;16766715;1719547;19243146;20664520;21596131;22673903;22906005;24363043;7761832;9069282;9417641", "class_list": "", "function": "AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser704., [RefSeq, PubMed]; AC2 is poised to yield both stimulatory and inhibitory outcomes of receptor activation., [RefSeq, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production (PubMed:24363043). Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (PubMed:22906005)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045121 membrane raft", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:1904322 cellular response to forskolin", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P26769-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35116-1", "uniprot_id": [ { "id": "CTND2_RAT", "url": "https://www.uniprot.org/uniprot/O35116", "type": "external" } ], "mass": 28928.0, "length": 264, "protein_name": "Catenin delta-2", "gene_name": "Ctnnd2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctnnd2", "gene_names_refseq": "", "protein_names_uniprotkb": "Catenin delta-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "major depressive disorder (Disease Ontology:DOID:1470); anxiety disorder (Disease Ontology:DOID:2030); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:114028)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10896674;17009320;18683930;20623542;22673903;25807484;38843836", "class_list": "", "function": "Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005912 adherens junction;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0050808 synapse organization;GO:0048167 regulation of synaptic plasticity;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35116-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LTR1-1", "uniprot_id": [ { "id": "WDR26_RAT", "url": "https://www.uniprot.org/uniprot/F1LTR1", "type": "external" } ], "mass": 58490.0, "length": 514, "protein_name": "WD repeat-containing protein 26", "gene_name": "Wdr26", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr26", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 26", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9861718)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22448652;27797717", "class_list": "", "function": "G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (By similarity). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:22448652). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (PubMed:27797717)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LTR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09034-1", "uniprot_id": [ { "id": "ASSY_RAT", "url": "https://www.uniprot.org/uniprot/P09034", "type": "external" } ], "mass": 46496.0, "length": 412, "protein_name": "Argininosuccinate synthase", "gene_name": "Ass1", "organism": "Rat", "refseq_name": "argininosuccinate synthase", "refseq_ac": [ { "id": "NP_037289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037289", "type": "external" } ], "gene_names_uniprotkb": "Ass1; Ass", "gene_names_refseq": "ASSA; Ass1; Ass", "protein_names_uniprotkb": "Argininosuccinate synthase; 6.3.4.5; Citrulline--aspartate ligase", "protein_names_refseq": "argininosuccinate synthase; argininosuccinate synthetase 1; arginosuccinate synthetase 1; citrulline--aspartate ligase", "tax_id": 10116, "disease": "classic citrullinemia (Disease Ontology:DOID:0070340); Alzheimer's disease (Disease Ontology:DOID:10652); uveitis (Disease Ontology:DOID:13141); melanoma (Disease Ontology:DOID:1909); hepatocellular carcinoma (Disease Ontology:DOID:684); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (rno:25698)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19491403;22673903;27247419;3174461", "class_list": "", "function": "One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed:19491403)., [UniProtKB, PubMed]; These studies demonstrate that increased amino acid flux can activate AMPK through increased AMP generated by ASS, thus providing a novel link between protein catabolism, ureagenesis, and hepatic lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0015643 toxic substance binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004055 argininosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0071400 cellular response to oleic acid;GO:0071242 cellular response to ammonium ion;GO:0001889 liver development;GO:0007584 response to nutrient;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09034-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5Y8-1", "uniprot_id": [ { "id": "ALS2_RAT", "url": "https://www.uniprot.org/uniprot/P0C5Y8", "type": "external" } ], "mass": 182448.0, "length": 1651, "protein_name": "Alsin", "gene_name": "Als2", "organism": "Rat", "refseq_name": "alsin", "refseq_ac": [ { "id": "NP_001013431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013431", "type": "external" } ], "gene_names_uniprotkb": "Als2", "gene_names_refseq": "Als2", "protein_names_uniprotkb": "Alsin; Amyotrophic lateral sclerosis 2 protein homolog", "protein_names_refseq": "ALS2, alsin Rho guanine nucleotide exchange factor; alsin; amyotrophic lateral sclerosis 2 (juvenile); amyotrophic lateral sclerosis 2 protein homolog; amyotrophic lateral sclerosis protein 2 homolog", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 2 (Disease Ontology:DOID:0060194); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:363235); (R-RNO-8876198); (R-RNO-9013149)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15033976;15686953;16802292;18482800;22673903", "class_list": "", "function": "Als2 gene encodes a large protein termed alsin, which contains a number of predicted cell signaling and protein trafficking sequence motifs., [RefSeq, PubMed]; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons., [UniProtKB, PubMed]; These results suggest that alsin binds cell membrane in a Ca(2+)-dependent manner through NCalpha and regulates membrane dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005813 centrosome", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006979 response to oxidative stress;GO:0007409 axonogenesis;GO:0007528 neuromuscular junction development;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C5Y8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00884-1", "uniprot_id": [ { "id": "ALDOB_RAT", "url": "https://www.uniprot.org/uniprot/P00884", "type": "external" } ], "mass": 39618.0, "length": 364, "protein_name": "Fructose-bisphosphate aldolase B", "gene_name": "Aldob", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aldob", "gene_names_refseq": "", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase B; 4.1.2.13; Liver-type aldolase", "protein_names_refseq": "", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); peritonitis (Disease Ontology:DOID:8283); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hereditary fructose intolerance syndrome (Disease Ontology:DOID:9869)", "pathway": " (rno:24190); (R-RNO-70171); (R-RNO-70263); (R-RNO-70350)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "1834654;22673903;2580098;6094564;6304044", "class_list": "", "function": "Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (By similarity). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70706", "ec_number_list": [ { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0031210 phosphatidylcholine binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005815 microtubule organizing center;GO:0030868 smooth endoplasmic reticulum membrane;GO:0034451 centriolar satellite", "go_biological_process": "GO:0001889 liver development;GO:0010043 response to zinc ion;GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00884-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06687-1", "uniprot_id": [ { "id": "AT1A3_RAT", "url": "https://www.uniprot.org/uniprot/P06687", "type": "external" } ], "mass": 111692.0, "length": 1013, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-3", "gene_name": "Atp1a3", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-3", "refseq_ac": [ { "id": "NP_036638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036638", "type": "external" } ], "gene_names_uniprotkb": "Atp1a3", "gene_names_refseq": "Atp1a3; Atpa1a3", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-3; 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Sodium pump subunit alpha-3", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 3 subunit; NA,K-ATPase alpha subunit 3; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ -ATPase alpha 3 subunit; sodium pump subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3", "tax_id": 10116, "disease": "alternating hemiplegia of childhood (Disease Ontology:DOID:0050635); familial hemiplegic migraine (Disease Ontology:DOID:0060178); developmental and epileptic encephalopathy 99 (Disease Ontology:DOID:0070385); dystonia 12 (Disease Ontology:DOID:0090056); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); keratoconus (Disease Ontology:DOID:10126); retinitis pigmentosa (Disease Ontology:DOID:10584); Huntington's disease (Disease Ontology:DOID:12858); disease of mental health (Disease Ontology:DOID:150); alcohol use disorder (Disease Ontology:DOID:1574); glaucoma (Disease Ontology:DOID:1686); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); hyperglycemia (Disease Ontology:DOID:4195); nervous system disease (Disease Ontology:DOID:863); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24213); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10.1039/D0MO00044B;22673903;23532852;25274047;2540801;26224839;2822682;2822726;3028470;34106099;38796484;38843836", "class_list": "", "function": "Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:2540801). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes. In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (By similarity)., [UniProtKB, PubMed, UniProtKB]; Neuronal autosis is Na[+]/K[+]-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death. Publication Status: Online-Only, [RefSeq, PubMed]; The PI 3-kinase/PKB signaling pathway is involved in the IGF-I-sustained basal (Na(+)/K(+))-ATPase activity during the first 7 days of the postnatal development of rat retina., [RefSeq, PubMed]; The amylospheroids target is neuron-specific Na(+)/K(+)-ATPase alpha3 subunit (NAKalpha3)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 17, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q16732;Q9Z1G6", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046959 habituation;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0007612 learning;GO:0007613 memory;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P06687-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80X08-1", "uniprot_id": [ { "id": "WASC2_RAT", "url": "https://www.uniprot.org/uniprot/Q80X08", "type": "external" } ], "mass": 145149.0, "length": 1328, "protein_name": "WASH complex subunit 2", "gene_name": "Washc2c; Washc2", "organism": "Rat", "refseq_name": "WASH complex subunit 2", "refseq_ac": [ { "id": "NP_954677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954677", "type": "external" } ], "gene_names_uniprotkb": "Washc2c; Washc2; Fam21c; Fam21", "gene_names_refseq": "Fam21c; Fam21; NP61201; Washc2c; Washc2", "protein_names_uniprotkb": "WASH complex subunit 2", "protein_names_refseq": "WASH complex subunit 2; WASH complex subunit FAM21; family with sequence similarity 21, member C", "tax_id": 10116, "disease": "", "pathway": " (rno:297530)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 27, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0036010 protein localization to endosome;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:2000813 negative regulation of barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80X08-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02454-1", "uniprot_id": [ { "id": "CO1A1_RAT", "url": "https://www.uniprot.org/uniprot/P02454", "type": "external" } ], "mass": 137953.0, "length": 1453, "protein_name": "Collagen alpha-1(I) chain", "gene_name": "Col1a1", "organism": "Rat", "refseq_name": "collagen alpha-1(I) chain precursor", "refseq_ac": [ { "id": "NP_445756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445756", "type": "external" } ], "gene_names_uniprotkb": "Col1a1", "gene_names_refseq": "COLIA1; Col1a1", "protein_names_uniprotkb": "Collagen alpha-1(I) chain; Alpha-1 type I collagen", "protein_names_refseq": "alpha-1 type I collagen; collagen alpha-1(I) chain precursor; collagen alpha-1(I) chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; type I-alpha 1 collagen", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); chronic pancreatitis (Disease Ontology:DOID:0051065); lupus nephritis (Disease Ontology:DOID:0080162); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Ehlers-Danlos syndrome arthrochalasia type 1 (Disease Ontology:DOID:0080727); osteogenesis imperfecta type 1 (Disease Ontology:DOID:0110334); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteoporosis (Disease Ontology:DOID:11476); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); beta thalassemia (Disease Ontology:DOID:12241); osteogenesis imperfecta (Disease Ontology:DOID:12347); alcoholic hepatitis (Disease Ontology:DOID:12351); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); thoracic aortic aneurysm (Disease Ontology:DOID:14004); aggressive periodontitis (Disease Ontology:DOID:1474); multiple sclerosis (Disease Ontology:DOID:2377); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); dermatofibrosarcoma protuberans (Disease Ontology:DOID:3507); pulmonary fibrosis (Disease Ontology:DOID:3770); dentinogenesis imperfecta (Disease Ontology:DOID:4154); systemic scleroderma (Disease Ontology:DOID:418); Caffey disease (Disease Ontology:DOID:4257); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); degenerative disc disease (Disease Ontology:DOID:90); cutaneous leishmaniasis (Disease Ontology:DOID:9111); liver benign neoplasm (Disease Ontology:DOID:916); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29393)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10065941;15817460;16751282;22673903;32328952;33497804;4126850;4290711;4327399;4335087;4342027;4366532;4636751;5337886;5411206;5777344;6395893", "class_list": "", "function": "COL1A1 as a potential new biomarker and therapeutic target for type 2 diabetes., [RefSeq, PubMed]; Expression of Metalloproteinases and Type I and III Collagens during Healing of Excisional Skin Wound on the Abdomen and Back in Rats., [RefSeq, PubMed]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 2, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A3KNA1;P02455;Q63079", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007584 response to nutrient;GO:0015031 protein transport;GO:0030335 positive regulation of cell migration;GO:0071300 cellular response to retinoic acid;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02454-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES67-1", "uniprot_id": [ { "id": "ARHGB_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES67", "type": "external" } ], "mass": 168534.0, "length": 1527, "protein_name": "Rho guanine nucleotide exchange factor 11", "gene_name": "Arhgef11", "organism": "Rat", "refseq_name": "rho guanine nucleotide exchange factor 11", "refseq_ac": [ { "id": "NP_076472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076472", "type": "external" } ], "gene_names_uniprotkb": "Arhgef11", "gene_names_refseq": "Arhgef11; Gtrap48", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 11; RhoGEF glutamate transport modulator GTRAP48", "protein_names_refseq": "Rho guanine nucleotide exchange factor (GEF) 11; RhoGEF glutamate transport modulator GTRAP48; glutamate transporter EAAT4 associated protein 48; rho guanine nucleotide exchange factor 11", "tax_id": 10116, "disease": "", "pathway": " (rno:78966); (R-RNO-193648); (R-RNO-416482); (R-RNO-416572); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "11242047;18226120;22673903;23696743;24106280;26172442;31612150;32148127", "class_list": "", "function": "Acute ethanol exposure increases EAAT4 activity at clinically relevant concentrations and that PKC and PI3K may mediate this., [RefSeq, PubMed]; Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study., [RefSeq, PubMed]; Genetic variants in Arhgef11 via increased expression and/or protein activity play a role in promoting kidney injury in the Dahl salt-sensitive rat through changes in cell morphology (Rho-Rock and/or EMT) that impact the function of tubule cells Publication Status: Online-Only, [RefSeq, PubMed]; Intrauterine hyperglycemia could cause obesity and abnormal glycolipid metabolism in female transgenerational offspring; the programming effect of the intrauterine environment could cause a more obvious phenotype in the maternal line. Further exploration suggested that increased expression of ARHGEF11 in the liver could be involved. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury., [RefSeq, PubMed]; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Galpha(q/11)--p63RhoGEF--RhoA axis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001664 G protein-coupled receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007266 Rho protein signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0002038 positive regulation of L-glutamate import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ES67-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLH5-1", "uniprot_id": [ { "id": "CK5P2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLH5", "type": "external" } ], "mass": 215482.0, "length": 1903, "protein_name": "CDK5 regulatory subunit-associated protein 2", "gene_name": "Cdk5rap2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk5rap2", "gene_names_refseq": "", "protein_names_uniprotkb": "CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48", "protein_names_refseq": "", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); primary autosomal recessive microcephaly 3 (Disease Ontology:DOID:0070286); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (rno:286919); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10721722;19553473;22673903", "class_list": "", "function": "Potential regulator of CDK5 activity via its interaction with CDK5R1 (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (By similarity). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (By similarity). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (By similarity). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (By similarity). Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "K7QQW0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0044877 protein-containing complex binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0045665 negative regulation of neuron differentiation;GO:0007420 brain development;GO:0045893 positive regulation of DNA-templated transcription;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JLH5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLH7-1", "uniprot_id": [ { "id": "CK5P3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLH7", "type": "external" } ], "mass": 57045.0, "length": 504, "protein_name": "CDK5 regulatory subunit-associated protein 3", "gene_name": "Cdk5rap3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdk5rap3", "gene_names_refseq": "", "protein_names_uniprotkb": "CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53", "protein_names_refseq": "", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709)", "pathway": " (rno:80278)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10721722;12054757;20531390", "class_list": "", "function": "Substrate adapter of E3 ligase complexes mediating ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, and which is involved in various processes, such as ribosome recycling and reticulophagy (also called ER-phagy) (By similarity). As part of the UREL complex, plays a key role in ribosome recycling by promoting mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome (By similarity). Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane (By similarity). Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum (By similarity). Within the UREL complex, CDK5RAP3 acts as a substrate adapter that constrains UFL1 ligase activity to mono-ufmylate RPL26/uL24 at 'Lys-134' (By similarity). The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3, thereby promoting lysosomal degradation of ufmylated proteins (By similarity). Also acts as a regulator of transcription: negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051019 mitogen-activated protein kinase binding;GO:0044877 protein-containing complex binding;GO:0051059 NF-kappaB binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0060318 definitive erythrocyte differentiation;GO:0001889 liver development;GO:0008283 cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JLH7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01283-1", "uniprot_id": [ { "id": "VIP_RAT", "url": "https://www.uniprot.org/uniprot/P01283", "type": "external" } ], "mass": 19079.0, "length": 170, "protein_name": "VIP peptides", "gene_name": "Vip", "organism": "Rat", "refseq_name": "VIP peptides preproprotein", "refseq_ac": [ { "id": "NP_446443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446443", "type": "external" } ], "gene_names_uniprotkb": "Vip", "gene_names_refseq": "Vip; vip/phi27", "protein_names_uniprotkb": "VIP peptides; Peptide histidine isoleucinamide 27; Vasoactive intestinal polypeptide", "protein_names_refseq": "VIP peptides preproprotein; VIP peptides; vasoactive intestinal polypeptide", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); uveitis (Disease Ontology:DOID:13141); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); periodontitis (Disease Ontology:DOID:824); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:117064); (R-RNO-420092)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "1851524;2159586;22673903;32212492;33098516;3379062;37119035;37218372;37646964;3838518;8402943", "class_list": "", "function": "Bioactive forms that cause vasodilation., [UniProtKB, UniProtKB]; Bioactive forms that cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin., [UniProtKB, UniProtKB]; Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury., [RefSeq, PubMed]; Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour., [RefSeq, PubMed]; Knockdown of miR-19a suppresses gastrointestinal dysmotility diarrhea after TBI by regulating VIP expression., [RefSeq, PubMed]; The expressions of CGRP and VIP were significantly down-regulated in the erectile dysfunction rat model, [RefSeq, PubMed]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (By similarity). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUN1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0044306 neuron projection terminus;GO:0005576 extracellular region", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0060406 positive regulation of penile erection;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007611 learning or memory;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P01283-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64537-1", "uniprot_id": [ { "id": "CPNS1_RAT", "url": "https://www.uniprot.org/uniprot/Q64537", "type": "external" } ], "mass": 28570.0, "length": 270, "protein_name": "Calpain small subunit 1", "gene_name": "Capns1; Cox7a1", "organism": "Rat", "refseq_name": "calpain small subunit 1", "refseq_ac": [ { "id": "NP_058814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058814", "type": "external" } ], "gene_names_uniprotkb": "Capns1; Cox7a1; Capn4; Capns1; Css1; LOC100910772; LOC100911363", "gene_names_refseq": "Capn4; Capns1", "protein_names_uniprotkb": "Calpain small subunit 1; CANP small subunit; CDPS; CSS1; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain regulatory subunit", "protein_names_refseq": "CANP small subunit; CDPS; CSS1; calcium-activated neutral proteinase small subunit; calcium-dependent protease small subunit 1; calpain 4; calpain regulatory subunit; calpain small subunit 1-like; calpain small subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29156); (R-RNO-1474228); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564); (R-RNO-9856530); (R-RNO-9860927)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "14579356;15476820;19020622;19020623;24297866;29393594;7982961;8950173;9228945", "class_list": "", "function": "Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)., [UniProtKB, UniProtKB]; This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97572;Q4V795", "ec_number_list": [], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0110158 calpain complex", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64537-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05065-1", "uniprot_id": [ { "id": "ALDOA_RAT", "url": "https://www.uniprot.org/uniprot/P05065", "type": "external" } ], "mass": 39352.0, "length": 364, "protein_name": "Fructose-bisphosphate aldolase A", "gene_name": "Aldoart2; Aldoa", "organism": "Rat", "refseq_name": "fructose-bisphosphate aldolase A", "refseq_ac": [ { "id": "NP_001170776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170776", "type": "external" } ], "gene_names_uniprotkb": "Aldoart2; Aldoa; Aldoart2", "gene_names_refseq": "Aldo1; Aldoa; RNALDOG5", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase A; 4.1.2.13; Muscle-type aldolase", "protein_names_refseq": "aldolase A, fructose-bisphosphate; fructose-bisphosphate aldolase A; muscle-type aldolase", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:24189); (rno:299052); (R-RNO-114608); (R-RNO-6798695); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "18683930;22673903;2416636;34502162;3753977;3783705;6086339", "class_list": "", "function": "Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis. In addition, also functions as a scaffolding protein. In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63038", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008092 cytoskeletal protein binding;GO:0004332 fructose-bisphosphate aldolase activity;GO:0070061 fructose binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0070062 extracellular exosome", "go_biological_process": "GO:0007339 binding of sperm to zona pellucida;GO:0032496 response to lipopolysaccharide;GO:0035094 response to nicotine;GO:0046716 muscle cell cellular homeostasis;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P05065-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01827-1", "uniprot_id": [ { "id": "VMAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q01827", "type": "external" } ], "mass": 55690.0, "length": 515, "protein_name": "Synaptic vesicular amine transporter", "gene_name": "Slc18a2", "organism": "Rat", "refseq_name": "synaptic vesicular amine transporter", "refseq_ac": [ { "id": "NP_037163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037163", "type": "external" } ], "gene_names_uniprotkb": "Slc18a2; Svat; Vmat2", "gene_names_refseq": "MNAT; Slc18a2; VMAT-2; VMAT2", "protein_names_uniprotkb": "Synaptic vesicular amine transporter; Monoamine transporter; Solute carrier family 18 member 2; VAT2; Vesicular amine transporter 2; Vesicular monoamine transporter 2", "protein_names_refseq": "Solute carrier family 18 A2 (vesicular monoamine transporter 2); VAT2; monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; solute carrier family 18 member 2; synaptic vesicular amine transporter; vesicular amine transporter 2", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); infantile parkinsonism-dystonia 2 (Disease Ontology:DOID:0070490); brain small vessel disease (Disease Ontology:DOID:0112313); Parkinson's disease (Disease Ontology:DOID:14330); Machado-Joseph disease (Disease Ontology:DOID:1440); anxiety disorder (Disease Ontology:DOID:2030); congenital afibrinogenemia (Disease Ontology:DOID:2236); substance-related disorder (Disease Ontology:DOID:303); toxic encephalopathy (Disease Ontology:DOID:3602); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25549); (R-RNO-181429); (R-RNO-181430); (R-RNO-212676)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "1438304;1505023;16301178;22673903;25355561;25496994;25943760;26956479;27821772;31955909;8125935;8606801;8745292;8860238;9045708", "class_list": "", "function": "Data suggest that expression of Vmat2 and Dat1 (dopamine transporter 1) in dopaminergic neurons in striatum can be down-regulated by dietary factors (here, ingestion of acrylamide, a food contaminant created by heating starchy foods)., [RefSeq, PubMed]; Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body., [RefSeq, PubMed]; Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:1438304, PubMed:25355561, PubMed:8125935, PubMed:8606801, PubMed:8860238). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (PubMed:16301178). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity) (PubMed:8860238)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Rotenone induces dopamine neuron death through a series of sequential events including microtubule destabilization, JNK3 activation, VMAT2 inhibition, accumulation of cytosolic dopamine, and generation of ROS., [RefSeq, PubMed]; Study identify mutants that alter the nature of the conformational equilibrium and mimic the protonated state of VMAT2. These mutants eliminate the requirement for a proton gradient normally necessary for reserpine binding and for reserpine inhibition of tetrabenazine binding., [RefSeq, PubMed]; Up-regulation of VMAT2 expression in aged male rats following chronic testosterone propionate treatment might be involved in the maintenance of dopaminergic function of the nigrostriatal dopaminergic system in aged male rats., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9QVP1", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0031072 heat shock protein binding;GO:0005275 amine transmembrane transporter activity;GO:0005335 serotonin:sodium:chloride symporter activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0071242 cellular response to ammonium ion;GO:0015844 monoamine transport;GO:0007626 locomotory behavior;GO:0010043 response to zinc ion;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q01827-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85972-1", "uniprot_id": [ { "id": "VINC_RAT", "url": "https://www.uniprot.org/uniprot/P85972", "type": "external" } ], "mass": 116615.0, "length": 1066, "protein_name": "Vinculin", "gene_name": "Vcl", "organism": "Rat", "refseq_name": "vinculin isoform 2", "refseq_ac": [ { "id": "NP_001100718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100718", "type": "external" } ], "gene_names_uniprotkb": "Vcl", "gene_names_refseq": "Vcl", "protein_names_uniprotkb": "Vinculin; Metavinculin", "protein_names_refseq": "metavinculin; vinculin isoform 2", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy 15 (Disease Ontology:DOID:0110321); dilated cardiomyopathy 1W (Disease Ontology:DOID:0110446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:305679); (R-RNO-114608); (R-RNO-445355); (R-RNO-5674135); (R-RNO-6798695); (R-RNO-9764561); (R-RNO-9856530); (R-RNO-9860927); (R-RNO-9958825)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "16641100;19343716;22673903;30354218;30502091", "class_list": "", "function": "Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Integrin engagement during cell attachment activates Poldip2/Nox4 to oxidize actin, which modulates filamentous actin assembly and its interaction with vinculin., [RefSeq, PubMed]; The vinculin-mediated mecahnotransduction mechanism in synthetic vascular smooth muscle cells may be more complex than those proposed for non-muscle cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KKR4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0031625 ubiquitin protein ligase binding;GO:0005198 structural molecule activity;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0090636 outer dense plaque of desmosome;GO:0090637 inner dense plaque of desmosome;GO:0061826 podosome ring;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0043297 apical junction assembly;GO:0051893 regulation of focal adhesion assembly;GO:1903140 regulation of establishment of endothelial barrier;GO:0007155 cell adhesion;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P85972-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1J6-1", "uniprot_id": [ { "id": "ZN652_RAT", "url": "https://www.uniprot.org/uniprot/A1L1J6", "type": "external" } ], "mass": 69558.0, "length": 608, "protein_name": "Zinc finger protein 652", "gene_name": "Zfp652; Znf652", "organism": "Rat", "refseq_name": "zinc finger protein 652", "refseq_ac": [ { "id": "NP_001073676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073676", "type": "external" } ], "gene_names_uniprotkb": "Zfp652; Znf652; Zfp652", "gene_names_refseq": "RGD1566329; Zfp652; Znf652", "protein_names_uniprotkb": "Zinc finger protein 652", "protein_names_refseq": "zinc finger protein 652", "tax_id": 10116, "disease": "", "pathway": " (rno:497984)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Functions as a transcriptional repressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1L1J6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08838-1", "uniprot_id": [ { "id": "AMPH_RAT", "url": "https://www.uniprot.org/uniprot/O08838", "type": "external" } ], "mass": 74878.0, "length": 683, "protein_name": "Amphiphysin", "gene_name": "Amph", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Amph; Amph1; LOC100909679", "gene_names_refseq": "", "protein_names_uniprotkb": "Amphiphysin", "protein_names_refseq": "", "tax_id": 10116, "disease": "centronuclear myopathy 2 (Disease Ontology:DOID:0111220)", "pathway": " (rno:60668); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10380931;10430869;16516836;16903783;17419807;18683930;22673903;9341169;9348539", "class_list": "", "function": "May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0044877 protein-containing complex binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007612 learning;GO:0043547 positive regulation of GTPase activity;GO:0045807 positive regulation of endocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O08838-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03248-1", "uniprot_id": [ { "id": "BUP1_RAT", "url": "https://www.uniprot.org/uniprot/Q03248", "type": "external" } ], "mass": 44042.0, "length": 393, "protein_name": "Beta-ureidopropionase", "gene_name": "Upb1", "organism": "Rat", "refseq_name": "beta-ureidopropionase", "refseq_ac": [ { "id": "NP_446297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446297", "type": "external" } ], "gene_names_uniprotkb": "Upb1; Bup1", "gene_names_refseq": "Bup1; Upb1", "protein_names_uniprotkb": "Beta-ureidopropionase; 3.5.1.6; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase", "protein_names_refseq": "N-carbamoyl-beta-alanine amidohydrolase; beta-alanine synthase; beta-ureidopropionase; ureidopropionase, beta", "tax_id": 10116, "disease": "", "pathway": " (rno:116593); (R-RNO-73621)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1536562;22673903;8449931", "class_list": "", "function": "Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003837 beta-ureidopropionase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization;GO:0019482 beta-alanine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q03248-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07969-1", "uniprot_id": [ { "id": "CD36_RAT", "url": "https://www.uniprot.org/uniprot/Q07969", "type": "external" } ], "mass": 52731.0, "length": 472, "protein_name": "Platelet glycoprotein 4", "gene_name": "Cd36l1; Cd36l2; Cd36", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cd36l1; Cd36l2; Cd36; Cd36-ps1; Cd36l1; Fat; LOC120093085; LOC134486712; RGD1565355", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet glycoprotein 4; Adipocyte membrane protein; Fatty acid translocase; Fatty acid transport protein; GPIIIB; GPIV; Glycoprotein IIIb; PAS IV; PAS-4; Platelet glycoprotein IV", "protein_names_refseq": "", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); atrial fibrillation (Disease Ontology:DOID:0060224); myeloid neoplasm (Disease Ontology:DOID:0070004); platelet-type bleeding disorder 10 (Disease Ontology:DOID:0111046); dermatomyositis (Disease Ontology:DOID:10223); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); polycystic ovary syndrome (Disease Ontology:DOID:11612); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); malaria (Disease Ontology:DOID:12365); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); atherosclerosis (Disease Ontology:DOID:1936); blood platelet disease (Disease Ontology:DOID:2218); essential thrombocythemia (Disease Ontology:DOID:2224); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); nephrosis (Disease Ontology:DOID:2527); endometriosis (Disease Ontology:DOID:289); pulmonary tuberculosis (Disease Ontology:DOID:2957); inclusion body myositis (Disease Ontology:DOID:3429); pulmonary fibrosis (Disease Ontology:DOID:3770); macular degeneration (Disease Ontology:DOID:4448); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); polycythemia vera (Disease Ontology:DOID:8997); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:499985); (R-RNO-114608); (R-RNO-1236973); (R-RNO-3000471); (R-RNO-434313); (R-RNO-5686938); (R-RNO-6798695)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "10409247;16276419;18332148;21454685;21610069;23557700;40154105;7504047;7688729;8320718", "class_list": "", "function": "Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long- and very long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (By similarity) (PubMed:8320718). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (PubMed:18332148, PubMed:8320718). Mechanistically, palmitoylated CD36 captures fatty acids on the cell surface, the binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36, a step needed to initiate the endocytic process and delivery of fatty acids into the cell (By similarity). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:16276419, PubMed:21610069). Involved in oral fat perception and preferences (By similarity) (PubMed:16276419). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity) (PubMed:16276419). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity) (PubMed:23557700). Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q925W0", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0070538 oleic acid binding;GO:0005044 scavenger receptor activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0001540 amyloid-beta binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:1990379 lipid transport across blood-brain barrier;GO:0098900 regulation of action potential;GO:0071221 cellular response to bacterial lipopeptide;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001676 long-chain fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07969-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P788-1", "uniprot_id": [ { "id": "ATF5_RAT", "url": "https://www.uniprot.org/uniprot/Q6P788", "type": "external" } ], "mass": 30205.0, "length": 281, "protein_name": "Cyclic AMP-dependent transcription factor ATF-5", "gene_name": "Atf5", "organism": "Rat", "refseq_name": "cyclic AMP-dependent transcription factor ATF-5", "refseq_ac": [ { "id": "NP_758839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758839", "type": "external" } ], "gene_names_uniprotkb": "Atf5; Atfx", "gene_names_refseq": "Atf5", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-5; Activating transcription factor 5; Transcription factor ATFx; cAMP-dependent transcription factor ATF-5", "protein_names_refseq": "cAMP-dependent transcription factor ATF-5; cyclic AMP-dependent transcription factor ATF-5; transcription factor ATFx", "tax_id": 10116, "disease": "", "pathway": " (rno:282840)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12805299;19531563;21212266;21791614", "class_list": "", "function": "ATF5 blocks the differentiation of neuroprogenitor cells into neurons and must be downregulated to permit this process to occur., [RefSeq, PubMed]; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity) (PubMed:19531563, PubMed:21212266). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity) (PubMed:12805299). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation. Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity) (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIT6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0031072 heat shock protein binding;GO:0019900 kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P788-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VGC3-1", "uniprot_id": [ { "id": "CACB2_RAT", "url": "https://www.uniprot.org/uniprot/Q8VGC3", "type": "external" } ], "mass": 73226.0, "length": 655, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-2", "gene_name": "Cacnb2", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-2 isoform 2", "refseq_ac": [ { "id": "NP_446303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446303", "type": "external" } ], "gene_names_uniprotkb": "Cacnb2; Cacnlb2", "gene_names_refseq": "Cacnb2; Cacnlb2", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Calcium channel voltage-dependent subunit beta 2", "protein_names_refseq": "CAB2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; voltage-dependent L-type calcium channel subunit beta-2 isoform 2; voltage-dependent L-type calcium channel subunit beta-2; voltage-gated calcium channel beta2i subunit", "tax_id": 10116, "disease": "Brugada syndrome 4 (Disease Ontology:DOID:0110221); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:116600); (R-RNO-112308); (R-RNO-422356); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11604404;12042350;1370480;15141227;20194790;22673903;24751537;26680202;30992131;35969184", "class_list": "", "function": "Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:12042350, PubMed:1370480). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (PubMed:12042350, PubMed:1370480). May modulate G protein inhibition (PubMed:11604404, PubMed:12042350, PubMed:1370480). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2., [RefSeq, PubMed]; The expression level of CACNB2 was up-regulated in the high salt (HS) diet fed Dahl Salt-Sensitive (SS) rat kidneys compared to low salt diet (LS) fed group. Similar to our in vitro observation the RAS-MAPK mRNA levels were increased in HS fed SS rat kidneys, compared to LS fed group., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811Q6;Q811Q7;Q91ZJ8;Q9QUU7", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098793 presynapse;GO:1990454 L-type voltage-gated calcium channel complex;GO:0005891 voltage-gated calcium channel complex;GO:0098684 photoreceptor ribbon synapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0086091 regulation of heart rate by cardiac conduction;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8VGC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62962-1", "uniprot_id": [ { "id": "ASIC2_RAT", "url": "https://www.uniprot.org/uniprot/Q62962", "type": "external" } ], "mass": 57739.0, "length": 512, "protein_name": "Acid-sensing ion channel 2", "gene_name": "Asic2", "organism": "Rat", "refseq_name": "acid-sensing ion channel 2 isoform MDEG1", "refseq_ac": [ { "id": "NP_001029186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029186", "type": "external" } ], "gene_names_uniprotkb": "Asic2; Accn1; Bnac1", "gene_names_refseq": "Accn1; Asic2; BNC1k; BNaC1; MDEG1; MDEG2; MDEG", "protein_names_uniprotkb": "Acid-sensing ion channel 2; ASIC2; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; BNC1; BNaC1; Brain sodium channel 1; MDEG; Mammalian degenerin homolog", "protein_names_refseq": "BNC1; acid-sensing (proton-gated) ion channel 2; acid-sensing ion channel 2 isoform MDEG1; acid-sensing ion channel 2; acid-sensing proton-gated ion channel 2 short variant MDEG2; amiloride-sensitive brain sodium channel 2; amiloride-sensitive cation channel 1, neuronal; brain sodium channel 1; degenerin", "tax_id": 10116, "disease": "", "pathway": " (rno:25364); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10842183;11457851;11588175;11842212;14976185;15504740;22673903;22850675;23034652;25744567;28725010;29739981;34215968;35447498;8631835;9360943;9368048", "class_list": "", "function": "A gain-of-function mutation in the acid-sensing ion channel 2a induces marked cerebellar maldevelopment in rats., [RefSeq, PubMed]; ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors., [RefSeq, PubMed]; ASICs may enhance susceptibility to epileptogenesis in the piriform cortex., [RefSeq, PubMed]; Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system (PubMed:10842183, PubMed:22850675, PubMed:8631835, PubMed:9360943, PubMed:9368048). Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize (PubMed:10842183, PubMed:8631835, PubMed:9368048). Highly selective for sodium, they are permeable to other cations (PubMed:8631835). By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Has no pH-gated sodium channel activity per se but can associate with other ASICs to produce functional channels with specific properties., [UniProtKB, PubMed]; Hippocampal glucose hypometabolism elevates ASIC2a expression by suppressing TFCP2 expression, which further enhances the intrinsic excitability of CA1 pyramidal neurons and increases seizure susceptibility in patients with temporal lobe epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings identify PcTx1 as a valuable tool for studying ASIC1a/2a function and contribute significantly to the understanding of the diverse and complex pharmacology of PcTx1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O55163", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0015280 ligand-gated sodium channel activity;GO:0022839 monoatomic ion-gated channel activity;GO:0005261 monoatomic cation channel activity;GO:0160125 pH-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0045202 synapse", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0043066 negative regulation of apoptotic process;GO:0019229 regulation of vasoconstriction;GO:0034220 monoatomic ion transmembrane transport;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q62962-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63102-1", "uniprot_id": [ { "id": "1433Z_RAT", "url": "https://www.uniprot.org/uniprot/P63102", "type": "external" } ], "mass": 27771.0, "length": 245, "protein_name": "14-3-3 protein zeta/delta", "gene_name": "Ywhaz", "organism": "Rat", "refseq_name": "14-3-3 protein zeta/delta", "refseq_ac": [ { "id": "NP_037143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037143", "type": "external" } ], "gene_names_uniprotkb": "Ywhaz; Msfs1", "gene_names_refseq": "14-3-3z; Ywhaz", "protein_names_uniprotkb": "14-3-3 protein zeta/delta; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein 1", "protein_names_refseq": "14-3-3 protein zeta/delta; KCIP-1; mitochondrial import stimulation factor S1 subunit; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide", "tax_id": 10116, "disease": "absence epilepsy (Disease Ontology:DOID:0070309); intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); temporal lobe epilepsy (Disease Ontology:DOID:3328); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:25578); (R-RNO-111447); (R-RNO-3769402); (R-RNO-392517); (R-RNO-430116); (R-RNO-450604); (R-RNO-512988); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-75035); (R-RNO-9013700); (R-RNO-9614399)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "11427721;12615066;16959763;21478148;22673903;27401462;34502162;7822263;7984035;8024705;8972907", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (By similarity). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (PubMed:16959763)., [UniProtKB, PubMed, UniProtKB]; Results indicate that HuR induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35215;P70197;P97286;Q52KK1;Q6IRF4", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031252 cell leading edge", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0003016 respiratory system process;GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P63102-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ6-1", "uniprot_id": [ { "id": "BSCL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ6", "type": "external" } ], "mass": 42409.0, "length": 377, "protein_name": "Seipin", "gene_name": "Bscl2", "organism": "Rat", "refseq_name": "seipin", "refseq_ac": [ { "id": "NP_001012171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012171", "type": "external" } ], "gene_names_uniprotkb": "Bscl2", "gene_names_refseq": "Bscl2", "protein_names_uniprotkb": "Seipin; Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog", "protein_names_refseq": "BSCL2, seipin lipid droplet biogenesis associated; Berardinelli-Seip congenital lipodystrophy 2 (seipin); bernardinelli-Seip congenital lipodystrophy type 2 protein homolog; seipin", "tax_id": 10116, "disease": "congenital generalized lipodystrophy (Disease Ontology:DOID:0050585); autosomal dominant distal hereditary motor neuronopathy 13 (Disease Ontology:DOID:0081401); hereditary spastic paraplegia 17 (Disease Ontology:DOID:0110770); congenital generalized lipodystrophy type 2 (Disease Ontology:DOID:0111136); male infertility (Disease Ontology:DOID:12336); azoospermia (Disease Ontology:DOID:14227); hereditary spastic paraplegia (Disease Ontology:DOID:2476); lipodystrophy (Disease Ontology:DOID:811); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:361722)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12584444;22673903;32705147;37897134", "class_list": "", "function": "Localization, cDNA sequence and genomic organization of the rat and sequence analysis in inbred rat models of Type 2 diabetes mellitus., [RefSeq, PubMed]; Mediates the formation of lipid droplets during the differentiation and maturation of adipocytes (By similarity). Together with LDAF1, defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm (By similarity). BSCL2 and LDAF1 also regulate protein and lipid delivery from the endoplasmic reticulum into growing lipid droplets: during early adipogenesis, BSCL2 inhibits GPAT3 and GPAT4 activity, thereby preventing phosphatidic acid accumulation that could antagonize PPARG and block differentiation. This inhibition is then relieved by ADIG during adipocyte maturation, allowing expansion of lipid droplets (By similarity). Regulates the maturation of ZFYVE1-positive nascent lipid droplets and the function of the RAB18-ZFYVE1 complex in mediating the formation of endoplasmic reticulum-lipid droplet contacts. Binds anionic phospholipids including phosphatidic acid (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR1873p inhibitor attenuates cerebral ischemia/reperfusion injury by regulating Seipinmediated autophagic flux., [RefSeq, PubMed]; Seipin overexpression attenuates cerebral ischemia-reperfusion injury via preventing apoptosis and autophagy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0043086 negative regulation of catalytic activity;GO:0050995 negative regulation of lipid catabolic process;GO:0045444 fat cell differentiation;GO:0019915 lipid storage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5FVJ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKB5-1", "uniprot_id": [ { "id": "ARI4B_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKB5", "type": "external" } ], "mass": 137080.0, "length": 1228, "protein_name": "AT-rich interactive domain-containing protein 4B", "gene_name": "Arid4b", "organism": "Rat", "refseq_name": "AT-rich interactive domain-containing protein 4B isoform 2", "refseq_ac": [ { "id": "NP_445873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445873", "type": "external" } ], "gene_names_uniprotkb": "Arid4b; Rbbp1l1; Sap180", "gene_names_refseq": "Arid4b; Bcaa", "protein_names_uniprotkb": "AT-rich interactive domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; ARID domain-containing protein 4B; Histone deacetylase complex subunit SAP180; Retinoblastoma-binding protein 1-like 1; Sin3-associated polypeptide p180", "protein_names_refseq": "180 kDa Sin3-associated polypeptide; ARID domain-containing protein 4B; AT rich interactive domain 4B (Rbp1 like); AT-rich interactive domain-containing protein 4B isoform 2; AT-rich interactive domain-containing protein 4B-like; AT-rich interactive domain-containing protein 4B; histone deacetylase complex subunit SAP180; retinoblastoma-binding protein 1-like 1; retinoblastoma-binding protein 1-related protein; sin3-associated polypeptide p180", "tax_id": 10116, "disease": "", "pathway": " (rno:84481); (R-RNO-3214815)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKB5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64535-1", "uniprot_id": [ { "id": "ATP7B_RAT", "url": "https://www.uniprot.org/uniprot/Q64535", "type": "external" } ], "mass": 155990.0, "length": 1451, "protein_name": "Copper-transporting ATPase 2", "gene_name": "Atp7b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp7b; Pina; Wnd", "gene_names_refseq": "", "protein_names_uniprotkb": "Copper-transporting ATPase 2; 7.2.2.8; Copper pump 2; Pineal night-specific ATPase; Wilson disease-associated protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 9 (Disease Ontology:DOID:0110593); occipital horn syndrome (Disease Ontology:DOID:0111272); autosomal recessive nonsyndromic deafness 110 (Disease Ontology:DOID:0111644); spinal muscular atrophy (Disease Ontology:DOID:12377); Menkes disease (Disease Ontology:DOID:1838); renal adenoma (Disease Ontology:DOID:2697); breast carcinoma (Disease Ontology:DOID:3459); liver carcinoma (Disease Ontology:DOID:686); Wilson disease (Disease Ontology:DOID:893); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (R-RNO-936837)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21454685;22673903;7951327;8037655;9920665", "class_list": "", "function": "Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63676;Q9JLY3", "ec_number_list": [ { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0005507 copper ion binding;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1990637 response to prolactin;GO:0006878 intracellular copper ion homeostasis;GO:0010043 response to zinc ion;GO:0007623 circadian rhythm;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q64535-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9H0-1", "uniprot_id": [ { "id": "ANKS3_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9H0", "type": "external" } ], "mass": 73048.0, "length": 663, "protein_name": "Ankyrin repeat and SAM domain-containing protein 3", "gene_name": "Anks3", "organism": "Rat", "refseq_name": "ankyrin repeat and SAM domain-containing protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001009676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009676", "type": "external" } ], "gene_names_uniprotkb": "Anks3", "gene_names_refseq": "Anks3; RGD1305833", "protein_names_uniprotkb": "Ankyrin repeat and SAM domain-containing protein 3", "protein_names_refseq": "ankyrin repeat and SAM domain-containing protein 3 isoform 1; ankyrin repeat and SAM domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:302937)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;25671767", "class_list": "", "function": "May be involved in vasopressin signaling in the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M9H0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1AAU6-1", "uniprot_id": [ { "id": "ASAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q1AAU6", "type": "external" } ], "mass": 127088.0, "length": 1144, "protein_name": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1", "gene_name": "Asap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Asap1; Ddef1", "gene_names_refseq": "", "protein_names_uniprotkb": "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; ARF GTPase-activating protein 1; DEF-1; Development and differentiation-enhancing factor 1; Differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:314961); (R-RNO-5620916)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1AAU4;Q1AAU5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0061000 negative regulation of dendritic spine development;GO:0071803 positive regulation of podosome assembly;GO:1903527 positive regulation of membrane tubulation;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1AAU6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920D5-1", "uniprot_id": [ { "id": "CASPC_RAT", "url": "https://www.uniprot.org/uniprot/Q920D5", "type": "external" } ], "mass": 47837.0, "length": 420, "protein_name": "Caspase-12", "gene_name": "Casp12", "organism": "Rat", "refseq_name": "caspase-12", "refseq_ac": [ { "id": "NP_569106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569106", "type": "external" } ], "gene_names_uniprotkb": "Casp12", "gene_names_refseq": "Casp12", "protein_names_uniprotkb": "Caspase-12; 3.4.22.-; CASP-12", "protein_names_refseq": "CASP-12; caspase-12", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); post-traumatic stress disorder (Disease Ontology:DOID:2055); brain ischemia (Disease Ontology:DOID:2316); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:156117)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12031969;12598725;22673903", "class_list": "", "function": "Immunohistochemical analysis reveals diffuse positive immunostaining of caspase-12 throughout the striatum and cerebral cortex in animals that undergo ischemia, with more intense caspase-12 staining in post-ischemic striatum than in post-ischemic cortex., [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Na/Ca exchanger overexpression, by depleting ER Ca(2+) stores, triggers the activation of caspase-12 and increases apoptotic cell death, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004175 endopeptidase activity;GO:0004197 cysteine-type endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0072558 NLRP1 inflammasome complex", "go_biological_process": "GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0006915 apoptotic process;GO:0050729 positive regulation of inflammatory response;GO:0070301 cellular response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q920D5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36877-1", "uniprot_id": [ { "id": "2ABB_RAT", "url": "https://www.uniprot.org/uniprot/P36877", "type": "external" } ], "mass": 51668.0, "length": 443, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform", "gene_name": "Ppp2r2b", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1", "refseq_ac": [ { "id": "NP_071545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071545", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r2b", "gene_names_refseq": "Ppp2r2b; Pppr2b2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform BRB; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta", "protein_names_refseq": "BRbeta B-regulatory subunit of protein phosphatase 2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1", "tax_id": 10116, "disease": "spinocerebellar ataxia 12 (Disease Ontology:DOID:0050962); Alzheimer's disease (Disease Ontology:DOID:10652); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); breast cancer (Disease Ontology:DOID:1612); systemic lupus erythematosus (Disease Ontology:DOID:9074); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:60660)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12716901;15923182;16641100;18940801;7607250;8389301", "class_list": "", "function": "The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80W84", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0007286 spermatid development;GO:0006626 protein targeting to mitochondrion;GO:0030182 neuron differentiation;GO:0043525 positive regulation of neuron apoptotic process;GO:0043653 mitochondrial fragmentation involved in apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36877-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYM0-1", "uniprot_id": [ { "id": "ANGE1_RAT", "url": "https://www.uniprot.org/uniprot/B2RYM0", "type": "external" } ], "mass": 75342.0, "length": 667, "protein_name": "RNA 2',3'-cyclic phosphatase ANGEL1", "gene_name": "Angel1", "organism": "Rat", "refseq_name": "RNA 2',3'-cyclic phosphatase ANGEL1", "refseq_ac": [ { "id": "NP_001102187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102187", "type": "external" } ], "gene_names_uniprotkb": "Angel1", "gene_names_refseq": "Angel1; RGD1306238", "protein_names_uniprotkb": "RNA 2',3'-cyclic phosphatase ANGEL1; 3.-.-.-", "protein_names_refseq": "RNA 2',3'-cyclic phosphatase ANGEL1; protein angel homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362765)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Exhibits weak RNA 2',3'-cyclic phosphatase, catalyzing the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group. Plays a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0003730 mRNA 3'-UTR binding;GO:0160272 RNA 2',3'-cyclic phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B2RYM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03343-1", "uniprot_id": [ { "id": "ADCY6_RAT", "url": "https://www.uniprot.org/uniprot/Q03343", "type": "external" } ], "mass": 130506.0, "length": 1166, "protein_name": "Adenylate cyclase type 6", "gene_name": "Adcy6", "organism": "Rat", "refseq_name": "adenylate cyclase type 6 isoform 2", "refseq_ac": [ { "id": "NP_036953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036953", "type": "external" } ], "gene_names_uniprotkb": "Adcy6", "gene_names_refseq": "AC6; ACVI; ADCYB; Adcy6", "protein_names_uniprotkb": "Adenylate cyclase type 6; 4.6.1.1; AC6; ACVI; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase", "protein_names_refseq": "ATP pyrophosphate-lyase 6; adenylate cyclase type 6 isoform 2; adenylate cyclase type 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase", "tax_id": 10116, "disease": "lethal congenital contracture syndrome (Disease Ontology:DOID:0060558); autosomal recessive nonsyndromic deafness 29 (Disease Ontology:DOID:0110487); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (rno:25289); (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-400042); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11877398;1332969;1409703;15385642;17110384;21606183;22673903;23132712;25769305;9391159", "class_list": "", "function": "AC isoform, and not the others expressed in PC12 cells, may reside in a plasma membrane compartment that is uniquely accessible to the family B Gs-coupled GPCR PAC1., [RefSeq, PubMed]; Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes., [RefSeq, PubMed]; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors (PubMed:1409703, PubMed:15385642, PubMed:17110384, PubMed:21606183). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells (PubMed:21606183). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA (PubMed:21606183). This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function (By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol (By similarity). Contributes to bone cell responses to mechanical stimuli (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0016020 membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0003091 renal water homeostasis;GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q03343-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02466-1", "uniprot_id": [ { "id": "CO1A2_RAT", "url": "https://www.uniprot.org/uniprot/P02466", "type": "external" } ], "mass": 129564.0, "length": 1372, "protein_name": "Collagen alpha-2(I) chain", "gene_name": "Col1a2", "organism": "Rat", "refseq_name": "collagen alpha-2(I) chain precursor", "refseq_ac": [ { "id": "NP_445808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445808", "type": "external" } ], "gene_names_uniprotkb": "Col1a2", "gene_names_refseq": "Col1a2", "protein_names_uniprotkb": "Collagen alpha-2(I) chain; Alpha-2 type I collagen", "protein_names_refseq": "alpha-2 type I collagen; collagen alpha-2(I) chain precursor; collagen alpha-2(I) chain; collagen, type I, alpha 2; procollagen, type I, alpha 2", "tax_id": 10116, "disease": "scoliosis (Disease Ontology:DOID:0060249); Ehlers-Danlos syndrome arthrochalasia type 2 (Disease Ontology:DOID:0080728); Ehlers-Danlos syndrome cardiac valvular type (Disease Ontology:DOID:0080730); osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 4 (Disease Ontology:DOID:0110340); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); intracranial aneurysm (Disease Ontology:DOID:10941); osteoporosis (Disease Ontology:DOID:11476); osteogenesis imperfecta (Disease Ontology:DOID:12347); dilated cardiomyopathy (Disease Ontology:DOID:12930); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459); pulmonary fibrosis (Disease Ontology:DOID:3770); heart valve disease (Disease Ontology:DOID:4079); ureteral obstruction (Disease Ontology:DOID:5199); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:84352); (R-RNO-114604); (R-RNO-1650814); (R-RNO-430116)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "16751282;19423663;26479776;36324232;4435743;4636752;4763308;5337886;5443712;5544653;5785232", "class_list": "", "function": "Nitration of cAMP-Response Element Binding Protein Participates in Myocardial Infarction-Induced Myocardial Fibrosis via Accelerating Transcription of Col1a2 and Cxcl12., [RefSeq, PubMed]; Type I collagen is a member of group I collagen (fibrillar forming collagen)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 1, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9R1E8", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005581 collagen trimer", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0071300 cellular response to retinoic acid;GO:0008217 regulation of blood pressure;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P02466-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8E6-1", "uniprot_id": [ { "id": "CAMP1_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8E6", "type": "external" } ], "mass": 178525.0, "length": 1604, "protein_name": "Calmodulin-regulated spectrin-associated protein 1", "gene_name": "Camsap1", "organism": "Rat", "refseq_name": "calmodulin-regulated spectrin-associated protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001162021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162021", "type": "external" } ], "gene_names_uniprotkb": "Camsap1", "gene_names_refseq": "Camsap1; RGD1565022", "protein_names_uniprotkb": "Calmodulin-regulated spectrin-associated protein 1", "protein_names_refseq": "calmodulin-regulated spectrin-associated protein 1 isoform 1", "tax_id": 10116, "disease": "complex cortical dysplasia with other brain malformations 12 (Disease Ontology:DOID:0061141)", "pathway": " (rno:296580)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18756519;19508979;22673903;24117850;38825498", "class_list": "", "function": "CAMSAP-conserved region represents a functional region of CAMSAP1, which links spectrin-binding to neurite outgrowth, [RefSeq, PubMed]; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (By similarity). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850)., [UniProtKB, UniProtKB, PubMed, PubMed]; MiR-411-5p Promotes Vascular Smooth Muscle Cell Phenotype Switch by Inhibiting Expression of Calmodulin Regulated Spectrin-Associated Protein-1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0036449 microtubule minus-end;GO:0072686 mitotic spindle", "go_biological_process": "GO:0031175 neuron projection development;GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0000226 microtubule cytoskeleton organization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3Z8E6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05941-1", "uniprot_id": [ { "id": "ACHA7_RAT", "url": "https://www.uniprot.org/uniprot/Q05941", "type": "external" } ], "mass": 56503.0, "length": 502, "protein_name": "Neuronal acetylcholine receptor subunit alpha-7", "gene_name": "Chrna7", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-7 precursor", "refseq_ac": [ { "id": "NP_036964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036964", "type": "external" } ], "gene_names_uniprotkb": "Chrna7; Acra7", "gene_names_refseq": "BTX; Chrna7; NARAD; nAChR7; nAChRa7", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-7; Nicotinic acetylcholine receptor subunit alpha-7; nAChR7", "protein_names_refseq": "C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha); bungarotoxin alpha; cholinergic receptor, nicotinic, alpha 7 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 7; neuronal acetylcholine receptor subunit alpha-7 precursor; neuronal acetylcholine receptor subunit alpha-7; neuronal nicotinic acetycholine receptor alpha 7; nicotinic acetylcholine receptor subunit alpha-7; nicotinic receptor alpha 7 subunit", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autism spectrum disorder (Disease Ontology:DOID:0060041); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); Huntington's disease (Disease Ontology:DOID:12858); lung cancer (Disease Ontology:DOID:1324); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); malignant pleural mesothelioma (Disease Ontology:DOID:7474); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25302); (R-RNO-629594)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "15927954;16120769;17510177;17709503;22250215;25740413;36912917;38070724;38198758;38302679;7678857", "class_list": "", "function": "Activating alpha7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway., [RefSeq, PubMed]; Alpha7nAChR Activation Combined with Endothelial Progenitor Cell Transplantation Attenuates Lung Injury in Diabetic Rats with Sepsis through the NF-kappaB Pathway., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:17510177). CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons (By similarity). Involved in the modulation of calcium-dependent signaling pathways and influences the release of neurotransmitters, including dopamine, glutamate and GABA (PubMed:17510177). Also expressed in non-neuronal cells such as immune cells like lymphocytes, monocytes and macrophages. In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (PubMed:17709503). In macrophages, required for acetylcholine-mediated inhibition of TNF and other inflammatory cytokine release. Once activated by acetylcholine, nicotine or other agonists, selectively inhibits production of pro-inflammatory cytokines while leaving anti-inflammatory cytokines undisturbed. Stimulates the cholinergic anti-inflammatory pathway, controlling inflammation by inhibiting NFKB nuclear translocation and activating the JAK2-STAT3 pathway, independently of ion channel activity (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through internal stores and decreasing basal ATP release (PubMed:22250215)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Enhancing cognitive function in chronic TBI: The Role of alpha7 nicotinic acetylcholine receptor modulation., [RefSeq, PubMed]; The Prenatal Hypoxic Pathology Associated with Maternal Stress Predisposes to Dysregulated Expression of the chrna7 Gene and the Subsequent Development of Nicotine Addiction in Adult Offspring., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q53YK2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005216 monoatomic ion channel activity;GO:0015464 acetylcholine receptor activity;GO:0015643 toxic substance binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q05941-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q704E8-1", "uniprot_id": [ { "id": "ABCB7_RAT", "url": "https://www.uniprot.org/uniprot/Q704E8", "type": "external" } ], "mass": 82558.0, "length": 752, "protein_name": "Iron-sulfur clusters transporter ABCB7, mitochondrial", "gene_name": "Abcb7", "organism": "Rat", "refseq_name": "iron-sulfur clusters transporter ABCB7, mitochondrial", "refseq_ac": [ { "id": "NP_997683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997683", "type": "external" } ], "gene_names_uniprotkb": "Abcb7", "gene_names_refseq": "Abcb7", "protein_names_uniprotkb": "Iron-sulfur clusters transporter ABCB7, mitochondrial; ABC transporter 7 protein; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7", "protein_names_refseq": "ABC transporter 7 protein; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; ATP-binding cassette, sub-family B, member 7, mitochondrial; ATP-binding cassette, subfamily B (MDR/TAP), member 7; iron-sulfur clusters transporter ABCB7, mitochondrial", "tax_id": 10116, "disease": "X-linked sideroblastic anemia with ataxia (Disease Ontology:DOID:0050554); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (rno:302395); (R-RNO-1369007)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16641100;31511561", "class_list": "", "function": "Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function. Publication Status: Online-Only, [RefSeq, PubMed]; Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (By similarity). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (By similarity). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (PubMed:31511561). May also play a role in hematopoiesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0034755 iron ion transmembrane transport;GO:0055085 transmembrane transport;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q704E8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80385-1", "uniprot_id": [ { "id": "AAKG1_RAT", "url": "https://www.uniprot.org/uniprot/P80385", "type": "external" } ], "mass": 37386.0, "length": 330, "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "Prkag1", "organism": "Rat", "refseq_name": "5'-AMP-activated protein kinase subunit gamma-1", "refseq_ac": [ { "id": "NP_037142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037142", "type": "external" } ], "gene_names_uniprotkb": "Prkag1", "gene_names_refseq": "Prkaac; Prkag1; Prkga1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg", "protein_names_refseq": "5'-AMP-activated protein kinase subunit gamma-1; AMP-activated protein kinase, noncatalytic gamma-1 subunit; AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit", "tax_id": 10116, "disease": "lethal congenital glycogen storage disease of heart (Disease Ontology:DOID:0090101); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); toxic encephalopathy (Disease Ontology:DOID:3602); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384)", "pathway": " (rno:25520); (R-RNO-1632852); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6804756); (R-RNO-9931269)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "17851531;21399626;21460634;21481774;22659875;25066137;33271223;38177907;7961907;8621499;8626596", "class_list": "", "function": "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive., [UniProtKB, PubMed, PubMed]; Adiponectin enhances the bioenergetics of cardiac myocytes via an AMPK- and succinate dehydrogenase-dependent mechanism., [RefSeq, PubMed]; S-nitrosylation of AMPKgamma impairs coronary collateral circulation and disrupts VSMC reprogramming., [RefSeq, PubMed]; Studies determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (alpha1beta1gamma1) through single-particle electron, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQW6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016208 AMP binding;GO:0043531 ADP binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006633 fatty acid biosynthetic process;GO:0051170 import into nucleus;GO:0050790 regulation of catalytic activity;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P80385-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A4Z3-1", "uniprot_id": [ { "id": "A3LT2_RAT", "url": "https://www.uniprot.org/uniprot/A0A4Z3", "type": "external" } ], "mass": 39548.0, "length": 339, "protein_name": "Alpha-1,3-galactosyltransferase 2", "gene_name": "A3galt2", "organism": "Rat", "refseq_name": "alpha-1,3-galactosyltransferase 2", "refseq_ac": [ { "id": "NP_612533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612533", "type": "external" } ], "gene_names_uniprotkb": "A3galt2", "gene_names_refseq": "A3galt2", "protein_names_uniprotkb": "Alpha-1,3-galactosyltransferase 2; 2.4.1.87; Isoglobotriaosylceramide synthase; iGb3 synthase; iGb3S", "protein_names_refseq": "alpha-1,3-galactosyltransferase 2; iGb3 synthase; iGb3S; isoglobotriaosylceramide synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:171553)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10854427;12626403;17206613;18630988;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A2JQW1", "ec_number_list": [ { "id": "2.4.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.87", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity;GO:0001962 alpha-1,3-galactosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0016020 membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0005975 carbohydrate metabolic process;GO:0071287 cellular response to manganese ion", "synthesized_glycan_count": 2, "hit_score": 0.6, "record_id": "A0A4Z3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5P0-1", "uniprot_id": [ { "id": "BORG5_RAT", "url": "https://www.uniprot.org/uniprot/A1A5P0", "type": "external" } ], "mass": 41029.0, "length": 388, "protein_name": "Cdc42 effector protein 1", "gene_name": "Cdc42ep1", "organism": "Rat", "refseq_name": "cdc42 effector protein 1", "refseq_ac": [ { "id": "NP_001073168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073168", "type": "external" } ], "gene_names_uniprotkb": "Cdc42ep1; Borg5", "gene_names_refseq": "Cdc42ep1", "protein_names_uniprotkb": "Cdc42 effector protein 1; Binder of Rho GTPases 5", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 1; binder of Rho GTPases 5; cdc42 effector protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315121); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0012505 endomembrane system", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A5P0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1PRL5-1", "uniprot_id": [ { "id": "CAVN4_RAT", "url": "https://www.uniprot.org/uniprot/B1PRL5", "type": "external" } ], "mass": 41093.0, "length": 362, "protein_name": "Caveolae-associated protein 4", "gene_name": "Cavin4", "organism": "Rat", "refseq_name": "caveolae-associated protein 4", "refseq_ac": [ { "id": "NP_001101401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101401", "type": "external" } ], "gene_names_uniprotkb": "Cavin4; Murc", "gene_names_refseq": "Cavin4; RGD1310395", "protein_names_uniprotkb": "Caveolae-associated protein 4; Muscle-related coiled-coil protein; Muscle-restricted coiled-coil protein", "protein_names_refseq": "caveolae-associated protein 4; muscle-related coiled-coil protein; muscle-restricted coiled-coil protein", "tax_id": 10116, "disease": "muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:313225)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18332105;22673903;24567387;26497963;30951783", "class_list": "", "function": "MURC modulates RhoA signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias., [RefSeq, PubMed]; MURC/cavin-4 requires its coiled-coil domain to target the plasma membrane and to stabilize Cav3 at the plasma membrane of cardiomyocytes, [RefSeq, PubMed]; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105)., [UniProtKB, PubMed, UniProtKB]; Study provides novel evidence that MURC regulates SOCE by interacting with STIM1 in cardiomyocytes. In addition, we identified a first potential mechanism by which the R140W mutation of MURC may contribute to calcium mishandling and the development of cardiomyopathies., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "B1PRL5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HL12-1", "uniprot_id": [ { "id": "AGRB1_RAT", "url": "https://www.uniprot.org/uniprot/C0HL12", "type": "external" } ], "mass": 172883.0, "length": 1577, "protein_name": "Adhesion G protein-coupled receptor B1", "gene_name": "Adgrb1", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor B1 precursor", "refseq_ac": [ { "id": "NP_001164068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164068", "type": "external" } ], "gene_names_uniprotkb": "Adgrb1; AABR07058422.1; Bai1", "gene_names_refseq": "Adgrb1; Bai1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1", "protein_names_refseq": "adhesion G protein-coupled receptor B1 precursor; brain-specific angiogenesis inhibitor 1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:362931)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;23595754", "class_list": "", "function": "Inhibits angiogenesis in a CD36-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibits angiogenesis., [UniProtKB, UniProtKB]; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (By similarity). Also mediates the binding and engulfment of Gram-negative bacteria (By similarity). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct dendritic localization of PARD3 and TIAM1 (PubMed:23595754). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0001530 lipopolysaccharide binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0HL12-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAR1-1", "uniprot_id": [ { "id": "ARH_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAR1", "type": "external" } ], "mass": 33785.0, "length": 306, "protein_name": "Low density lipoprotein receptor adapter protein 1", "gene_name": "Ldlrap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ldlrap1; Arh", "gene_names_refseq": "", "protein_names_uniprotkb": "Low density lipoprotein receptor adapter protein 1; Autosomal recessive hypercholesterolemia protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive hypercholesterolemia (Disease Ontology:DOID:0090105)", "pathway": " (rno:500564); (R-RNO-196791); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8964026); (R-RNO-8964038); (R-RNO-9758890)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "22509010;22673903;23836931", "class_list": "", "function": "Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface (By similarity). Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (PubMed:23836931)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0001540 amyloid-beta binding;GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0030424 axon;GO:0055037 recycling endosome", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0031623 receptor internalization;GO:0042632 cholesterol homeostasis;GO:0042982 amyloid precursor protein metabolic process;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZAR1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z173-1", "uniprot_id": [ { "id": "AGRL3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z173", "type": "external" } ], "mass": 172442.0, "length": 1550, "protein_name": "Adhesion G protein-coupled receptor L3", "gene_name": "Adgrl3", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor L3 precursor", "refseq_ac": [ { "id": "NP_570835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570835", "type": "external" } ], "gene_names_uniprotkb": "Adgrl3; Cirl3; Cl3; Lphn3", "gene_names_refseq": "Adgrl3; CIRL-3; Cirl3; Lec3; Lphn3", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L3; CIRL-3; Calcium-independent alpha-latrotoxin receptor 3; Latrophilin-3", "protein_names_refseq": "adhesion G protein-coupled receptor L3 precursor; calcium-independent alpha-latrotoxin receptor 3; calcium-independent alpha-latrotoxin receptor homolog 3; latrophilin-3; lectomedin-3", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:170641)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10026162;22405201;31176715;32203648;34352385;35985692;38843836;9830014", "class_list": "", "function": "A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats., [RefSeq, PubMed]; Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats., [RefSeq, PubMed]; Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity., [RefSeq, PubMed]; New Lphn3 knockout-out rat data collectively show that its disruption is significantly correlated with hyperactivity and associated striatal changes in dopamine markers., [RefSeq, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G protein-coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation., [UniProtKB, UniProtKB]; Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "O88924;O88925;O88926;O88927;O88928;O88929;Q4LDM4;Q4LDM5;Q4LDM6;Q4LDM7;Q4LDM8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0140693 molecular condensate scaffold activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030424 axon;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9Z173-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQJ0-1", "uniprot_id": [ { "id": "CLD15_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQJ0", "type": "external" } ], "mass": 24312.0, "length": 227, "protein_name": "Claudin-15", "gene_name": "Cldn15", "organism": "Rat", "refseq_name": "claudin-15", "refseq_ac": [ { "id": "NP_001100605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100605", "type": "external" } ], "gene_names_uniprotkb": "Cldn15", "gene_names_refseq": "Cldn15", "protein_names_uniprotkb": "Claudin-15", "protein_names_refseq": "claudin-15", "tax_id": 10116, "disease": "", "pathway": " (rno:304388)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16505581;22673903;33903003", "class_list": "", "function": "Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury., [RefSeq, PubMed]; Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0160187 paracellular tight junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0070160 tight junction", "go_biological_process": "GO:1904729 regulation of intestinal lipid absorption;GO:0006811 monoatomic ion transport;GO:0045471 response to ethanol;GO:0160184 paracellular transport;GO:1903985 regulation of intestinal D-glucose absorption", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZQJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB98-1", "uniprot_id": [ { "id": "AF1L1_RAT", "url": "https://www.uniprot.org/uniprot/D4AB98", "type": "external" } ], "mass": 86875.0, "length": 767, "protein_name": "Actin filament-associated protein 1-like 1", "gene_name": "Afap1l1", "organism": "Rat", "refseq_name": "actin filament-associated protein 1-like 1", "refseq_ac": [ { "id": "NP_001099612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099612", "type": "external" } ], "gene_names_uniprotkb": "Afap1l1", "gene_names_refseq": "Afap1l1; RGD1311580", "protein_names_uniprotkb": "Actin filament-associated protein 1-like 1; AFAP1-like protein 1", "protein_names_refseq": "AFAP1-like protein 1; actin filament-associated protein 1-like 1; actin filament-associated protein, 110 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:291565)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in podosome and invadosome formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0002102 podosome;GO:0042995 cell projection;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4AB98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97562-1", "uniprot_id": [ { "id": "ACOX2_RAT", "url": "https://www.uniprot.org/uniprot/P97562", "type": "external" } ], "mass": 76799.0, "length": 681, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 2", "gene_name": "Acox2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Acox2; Thcox", "gene_names_refseq": "", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 2; 1.3.3.6; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Branched-chain acyl-CoA oxidase 2; THCA-CoA oxidase; THCCox; Trihydroxycoprostanoyl-CoA oxidase", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital bile acid synthesis defect 6 (Disease Ontology:DOID:0111067)", "pathway": " (rno:252898); (R-RNO-193368); (R-RNO-389887); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1400324;16396499;8947475", "class_list": "", "function": "Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs) and bile acids intermediates. Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product. Oxidizes its substrates in a stereospecific way and can only desaturate isomers carrying (2S)-methyl groups (Probable). In brown adipose tissue peroxisomes, mediates beta-oxidation of monomethyl branched-chain fatty acids with iso configuration (mmBCFAs) as part of a substrate synthesis and oxidation cycle fueled by FASN-dependent de novo mmBCFA synthesis. The mmBCFA catabolism is coupled to AMPK activation and mitochondrial ATP production as a thermogenic adaptation mechanism to maintain the body temperature in cold environment (By similarity). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (Probable). In the liver, mediates side-chain beta-oxidation of C27 bile acyl-CoA intermediates carrying a (25S)-methyl group to yield 24,25-trans unsaturated derivatives as part of peroxisomal bile acid synthesis pathway (Probable). Can oxidize straight-chain fatty acyl CoAs such as C10-CoA and C16-CoA with low efficiency (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity;GO:0120524 long-chain fatty acyl-CoA oxidase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97562-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07872-1", "uniprot_id": [ { "id": "ACOX1_RAT", "url": "https://www.uniprot.org/uniprot/P07872", "type": "external" } ], "mass": 74679.0, "length": 661, "protein_name": "Peroxisomal acyl-coenzyme A oxidase 1", "gene_name": "Acox1", "organism": "Rat", "refseq_name": "peroxisomal acyl-coenzyme A oxidase 1 isoform 2", "refseq_ac": [ { "id": "NP_059036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059036", "type": "external" } ], "gene_names_uniprotkb": "Acox1; Acox", "gene_names_refseq": "ACO; AOX; Acox1; RATACOA1; aCoA", "protein_names_uniprotkb": "Peroxisomal acyl-coenzyme A oxidase 1; 1.3.3.6; ACO; AOX; Palmitoyl-CoA oxidase; Peroxisomal fatty acyl-CoA oxidase; Straight-chain acyl-CoA oxidase", "protein_names_refseq": "acyl-CoA oxidase 1, palmitoyl; acyl-Coenzyme A oxidase 1, palmitoyl; palmitoyl-CoA oxidase; peroxisomal acyl-coenzyme A oxidase 1 isoform 2; peroxisomal acyl-coenzyme A oxidase 1-like; peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; straight-chain acyl-CoA oxidase", "tax_id": 10116, "disease": "peroxisomal acyl-CoA oxidase deficiency (Disease Ontology:DOID:0050797); Mitchell syndrome (Disease Ontology:DOID:0070516); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:50681); (R-RNO-2046106); (R-RNO-390247); (R-RNO-9033241)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11872165;1400324;16672280;26092479;28077576;3036800;3036801;32169171;7462191;7503725", "class_list": "", "function": "Inhibition of ACOX1 is a novel and effective approach for the treatment of high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism, [RefSeq, PubMed]; Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes (By similarity). Involved in VLCFA-dependent hepatic-to-adipose tissue inter-organ signaling in response to diet. Through hepatic beta-oxidation of THA, may regulate THA systemic levels and THA-dependent activation of FFAR4 signaling in adipocytes, limiting adipose tissue thermogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Is active against a much broader range of substrates and shows activity towards long-chain acyl-CoAs., [UniProtKB, PubMed]; Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro., [UniProtKB, PubMed]; Tau supplementation prevented obesity and hepatic TG deposition by upregulating MTP mRNA, ameliorating hepatic lipid efflux, and consequently enhancing PPAR-alpha which increases lipid oxidation through ACO and CPT-1a gene expressions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11354", "ec_number_list": [ { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0003997 acyl-CoA oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0006091 generation of precursor metabolites and energy;GO:0006629 lipid metabolic process;GO:0007283 spermatogenesis;GO:0009062 fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P07872-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35430-1", "uniprot_id": [ { "id": "APBA1_RAT", "url": "https://www.uniprot.org/uniprot/O35430", "type": "external" } ], "mass": 92654.0, "length": 839, "protein_name": "Amyloid-beta A4 precursor protein-binding family A member 1", "gene_name": "Apba1", "organism": "Rat", "refseq_name": "amyloid-beta A4 precursor protein-binding family A member 1", "refseq_ac": [ { "id": "NP_113967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113967", "type": "external" } ], "gene_names_uniprotkb": "Apba1; Mint1; X11", "gene_names_refseq": "Apba1; Mint1", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family A member 1; Adapter protein X11alpha; Mint-1; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1", "protein_names_refseq": "adapter protein X11alpha; amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid-beta A4 precursor protein-binding family A member 1; mint-1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83589); (R-RNO-212676)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "18007179;20531236;22355143;22673903;25378388;33159991;9395480;9753324", "class_list": "", "function": "CASK, APBA1, and STXBP1 collaborate during insulin secretion., [RefSeq, PubMed]; Data show that scaffold protein X11alpha modulates kalirin-7 localization in dendrites and recruits it to Golgi outposts., [RefSeq, PubMed]; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta., [UniProtKB]; Upon neurodegeneration with okadaic acid, mint-1 and mint-2 levels were reduced by proteolytic cleavage, and these changes were followed by increases in APP levels., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006886 intracellular protein transport;GO:0007626 locomotory behavior;GO:0007268 chemical synaptic transmission;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35430-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05539-1", "uniprot_id": [ { "id": "CO2A1_RAT", "url": "https://www.uniprot.org/uniprot/P05539", "type": "external" } ], "mass": 134570.0, "length": 1419, "protein_name": "Collagen alpha-1(II) chain", "gene_name": "Col2a1", "organism": "Rat", "refseq_name": "collagen alpha-1(II) chain isoform 2 precursor", "refseq_ac": [ { "id": "NP_037061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037061", "type": "external" } ], "gene_names_uniprotkb": "Col2a1", "gene_names_refseq": "CG2A1A; COLLII; Col2a1", "protein_names_uniprotkb": "Collagen alpha-1(II) chain; Alpha-1 type II collagen", "protein_names_refseq": "Procollagen II alpha 1; alpha-1 type II collagen; collagen alpha-1(II) chain isoform 2 precursor; collagen alpha-1(II) chain; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; procollagen, type II, alpha 1", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia (Disease Ontology:DOID:0080027); spondyloepimetaphyseal dysplasia, Strudwick type (Disease Ontology:DOID:0080028); hypochondrogenesis (Disease Ontology:DOID:0080044); Kniest dysplasia (Disease Ontology:DOID:0080045); Stickler syndrome (Disease Ontology:DOID:0080046); achondrogenesis type II (Disease Ontology:DOID:0080056); Stickler syndrome 1 (Disease Ontology:DOID:0080676); infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly (Disease Ontology:DOID:0111262); multiple epiphyseal dysplasia with myopia and deafness (Disease Ontology:DOID:0111348); Torrance type platyspondylic dysplasia (Disease Ontology:DOID:0111508); spondyloperipheral dysplasia (Disease Ontology:DOID:0112195); spondyloepiphyseal dysplasia Stanescu type (Disease Ontology:DOID:0112281); spondylometaphyseal dysplasia Algerian type (Disease Ontology:DOID:0112296); osteonecrosis (Disease Ontology:DOID:10159); spondyloarthropathy (Disease Ontology:DOID:1123); myopia (Disease Ontology:DOID:11830); Legg-Calve-Perthes disease (Disease Ontology:DOID:14415); hypothyroidism (Disease Ontology:DOID:1459); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); osteochondrodysplasia (Disease Ontology:DOID:2256); chondrosarcoma (Disease Ontology:DOID:3371); retinal detachment (Disease Ontology:DOID:5327); eye disease (Disease Ontology:DOID:5614); cleft palate (Disease Ontology:DOID:674); osteoarthritis (Disease Ontology:DOID:8398); chorioretinitis (Disease Ontology:DOID:8886); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:25412); (R-RNO-1442490); (R-RNO-1566977); (R-RNO-1650814); (R-RNO-186797); (R-RNO-2022090); (R-RNO-216083); (R-RNO-3000171); (R-RNO-3000178); (R-RNO-419037); (R-RNO-8874081); (R-RNO-8948216)", "pathway_count": 12, "publication_count": 29, "publication_id_list": "11056672;12115661;12516572;15383610;15535832;15682451;16704744;16762555;17641008;18163493;19174762;20309862;20686129;21757687;22392632;23041839;23116329;27881681;29706949;2984204;30938133;30981839;32448385;33383116;6094525;8046350;8765038;9521085;9693969", "class_list": "", "function": "E1 and E2 enhancer activities in type II collagen and aggrecan are regulated through distinct epigenetic modifications by histone deacetylase 10 and sirtuin 6., [RefSeq, PubMed]; Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B., [RefSeq, PubMed]; Induction of OA caused downregulation of Col2a1. Expression of Col2a1 showed upregulation in therapeutic group with separate administration chondroitin sulfate or a probiotic diet and the cumulative effects in case of co-administration., [RefSeq, PubMed]; These findings suggest a novel mechanism of action of SOX5/6; namely, the SOX9/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1., [RefSeq, PubMed]; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 1, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q63123;Q63565;Q78DY3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0043394 proteoglycan binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0071300 cellular response to retinoic acid;GO:0001894 tissue homeostasis;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "P05539-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFG5-1", "uniprot_id": [ { "id": "CA2D3_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFG5", "type": "external" } ], "mass": 122204.0, "length": 1085, "protein_name": "Voltage-dependent calcium channel subunit alpha-2/delta-3", "gene_name": "Cacna2d3", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel subunit alpha-2/delta-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_783185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783185", "type": "external" } ], "gene_names_uniprotkb": "Cacna2d3", "gene_names_refseq": "Cacna2d3", "protein_names_uniprotkb": "Voltage-dependent calcium channel subunit alpha-2/delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3", "protein_names_refseq": "calcium channel, voltage-dependent, alpha 2/delta 3 subunit; calcium channel, voltage-dependent, alpha2/delta subunit 3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform 1 precursor; voltage-dependent calcium channel subunit alpha-2/delta-3; voltage-gated calcium channel subunit alpha-2/delta-3", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (rno:306243); (R-RNO-112308)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12606261;16641100;20080692;25631988;33986433;38843836", "class_list": "", "function": "All of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.[Cacna2d3, [RefSeq, PubMed]; Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit alpha2delta-1 but not alpha2delta-3. Publication Status: Online-Only, [RefSeq, PubMed]; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity)., [UniProtKB]; The expression of the alpha(2)delta(3) calcium channel subunit to multiple cell types suggests that this subunit participates widely in Ca-channel-mediated signaling in the retina., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0005262 calcium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005891 voltage-gated calcium channel complex;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0006816 calcium ion transport;GO:1990314 cellular response to insulin-like growth factor stimulus;GO:0099174 regulation of presynapse organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CFG5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35889-1", "uniprot_id": [ { "id": "AFAD_RAT", "url": "https://www.uniprot.org/uniprot/O35889", "type": "external" } ], "mass": 207678.0, "length": 1829, "protein_name": "Afadin", "gene_name": "Afdn", "organism": "Rat", "refseq_name": "afadin", "refseq_ac": [ { "id": "NP_037349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037349", "type": "external" } ], "gene_names_uniprotkb": "Afdn; Af6; Mllt4", "gene_names_refseq": "Af6; Afdn; Mllt4", "protein_names_uniprotkb": "Afadin; Afadin adherens junction formation factor; Protein Af-6", "protein_names_refseq": "afadin; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; protein Af-6; translocated to, 4", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:26955); (R-RNO-418990)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;30268521;30463011;30572094;9334353", "class_list": "", "function": "Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (PubMed:9334353). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:9334353). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spatiotemporal and dynamic alternative splicing produces differential expression patterns of afadin isoforms and alternative splicing of afadin is controlled by the neuron-specific regulator(s) whose activity is triggered and dynamically altered during neuronal differentiation and maturation., [RefSeq, PubMed]; Study found that afadin undergoes a bi-directional trafficking to both synaptic and nuclear compartment in response to acute 17beta-estradiol (estradiol) treatment, in mixed sex neuronal cultures derived from fetal cortex. Nuclear accumulation of afadin was coincidental with an increase in the phosphorylation of histone H3 at serine 10 (H3S10p). This epigenetic modification is associated with the remodeling of chromatin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35890", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0050839 cell adhesion molecule binding;GO:0031267 small GTPase binding;GO:0030274 LIM domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:1903861 positive regulation of dendrite extension;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O35889-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63622-1", "uniprot_id": [ { "id": "DLG2_RAT", "url": "https://www.uniprot.org/uniprot/Q63622", "type": "external" } ], "mass": 94934.0, "length": 852, "protein_name": "Disks large homolog 2", "gene_name": "Dlg2", "organism": "Rat", "refseq_name": "disks large homolog 2 isoform 1", "refseq_ac": [ { "id": "NP_071618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071618", "type": "external" } ], "gene_names_uniprotkb": "Dlg2; Dlgh2", "gene_names_refseq": "Dlg2; Dlgh2", "protein_names_uniprotkb": "Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93", "protein_names_refseq": "channel-associated protein of synapse-110; chapsyn-110; discs, large homolog 2; disks large 1 tumor suppressor protein-like; disks large homolog 2 isoform 1; disks large homolog 2; postsynaptic density protein PSD-93; synaptic density protein PSD-93", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:64053); (R-RNO-438066); (R-RNO-5673001); (R-RNO-6794361)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10779526;11095503;11997254;15304517;16630835;19118189;20089912;21119615;22673903;35115661;37705179;8625413;8755482;8922396", "class_list": "", "function": "A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder., [RefSeq, PubMed]; Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. Erratum:[Neuropsychopharmacology. 2024 Mar;49(4):766. doi: 10.1038/s41386-024-01801-w. PMID: 38225398], [RefSeq, PubMed]; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70548;Q62939", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0019233 sensory perception of pain;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63622-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811Q2-1", "uniprot_id": [ { "id": "CLIC6_RAT", "url": "https://www.uniprot.org/uniprot/Q811Q2", "type": "external" } ], "mass": 64687.0, "length": 612, "protein_name": "Chloride intracellular channel protein 6", "gene_name": "Clic6", "organism": "Rat", "refseq_name": "chloride intracellular channel protein 6", "refseq_ac": [ { "id": "NP_788267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788267", "type": "external" } ], "gene_names_uniprotkb": "Clic6; Clic6b", "gene_names_refseq": "Clic6b; Clic6", "protein_names_uniprotkb": "Chloride intracellular channel protein 6; 1.8.-.-; Glutaredoxin-like oxidoreductase CLIC6", "protein_names_refseq": "chloride intracellular channel 6; chloride intracellular channel protein 6; glutaredoxin-like oxidoreductase CLIC6; intracellular chloride channel 6b", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:304081)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14499480;22673903", "class_list": "", "function": "In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (By similarity). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0031751 D4 dopamine receptor binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity;GO:0031749 D2 dopamine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0034707 chloride channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q811Q2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09137-1", "uniprot_id": [ { "id": "AAPK2_RAT", "url": "https://www.uniprot.org/uniprot/Q09137", "type": "external" } ], "mass": 62258.0, "length": 552, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "Prkaa2", "organism": "Rat", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "refseq_ac": [ { "id": "NP_076481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076481", "type": "external" } ], "gene_names_uniprotkb": "Prkaa2; Ampk2; Ampk", "gene_names_refseq": "Ampka2; Ampk; Prkaa2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-2; 2.7.11.1; 2.7.11.31; ACACA kinase; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-2; ACACA kinase; AMP-activated protein kinase; AMPK alpha-2 chain; AMPK subunit alpha-2; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 2 catalytic subunit", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:78975); (R-RNO-1632852); (R-RNO-163680); (R-RNO-200425); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6804756); (R-RNO-9759194); (R-RNO-9931269)", "pathway_count": 9, "publication_count": 117, "publication_id_list": "10025949;10642499;11069105;11576526;11598104;11724780;12015362;12065600;12086935;12441311;12740371;12764152;14511394;14614828;14709557;15165993;15265760;15381965;15465886;15653571;15733742;16054095;16054096;16648175;17147515;17147517;17341212;18353182;18502256;18927218;19073152;19154959;19940100;20189584;20190100;20399918;20682696;21373642;21460634;21543456;21887385;21963396;22653991;22673903;23095119;23112775;23152807;23667622;2369897;23762489;24288442;24382180;24444314;24855629;25103217;25687571;25779766;25996822;26054749;26542263;27239415;27348124;27375435;28377726;29695972;29799853;29873129;29921218;30081580;30135928;30223807;30292140;30545741;30695051;30770790;31182708;31362343;31515530;31678999;31684957;31813919;31996711;32010479;32034884;32053588;32107468;32121602;32164219;32323727;32446297;32554851;32656262;32765945;32783890;32879422;32893519;32903813;32959498;32961871;33014221;33020662;33546773;33627946;33732083;33879516;33919975;36269629;36474308;37774988;37816196;37926341;38493917;38653383;7718624;7908907;8910387;9029219", "class_list": "", "function": "Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1. Publication Status: Online-Only, [RefSeq, PubMed]; Calcineurin suppresses rat H9c2 cardiomyocyteprotective autophagy under chronic intermittent hypoxia by downregulating the AMPK pathway., [RefSeq, PubMed]; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14511394). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:2369897, PubMed:9029219). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (PubMed:11069105, PubMed:11598104, PubMed:12065600). Involved in insulin receptor/INSR internalization (By similarity). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11724780, PubMed:12740371). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (By similarity). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (By similarity). In that process, it also activates WDR45/WIPI4 (By similarity). Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:10025949, PubMed:14709557, PubMed:17341212). Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation (By similarity). Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity). Upon glucose starvation, promotes ARF6 activation in a kinase-independent manner leading to cell migration (By similarity). Upon glucose deprivation mediates the phosphorylation of ACSS2 at 'Ser-659', which exposes the nuclear localization signal of ACSS2, required for its interaction with KPNA1 and nuclear translocation (By similarity). Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis., [RefSeq, PubMed]; Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina., [RefSeq, PubMed]; Stress can affect mitochondrial energy metabolism and AMPK/SIRT1 signaling pathway in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008610 lipid biosynthetic process;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 11.8, "record_id": "Q09137-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35158-1", "uniprot_id": [ { "id": "CDON_RAT", "url": "https://www.uniprot.org/uniprot/O35158", "type": "external" } ], "mass": 136204.0, "length": 1256, "protein_name": "Cell adhesion molecule-related/down-regulated by oncogenes", "gene_name": "Cdon", "organism": "Rat", "refseq_name": "cell adhesion molecule-related/down-regulated by oncogenes precursor", "refseq_ac": [ { "id": "NP_059054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059054", "type": "external" } ], "gene_names_uniprotkb": "Cdon; Cdo", "gene_names_refseq": "Cdon; Cdo", "protein_names_uniprotkb": "Cell adhesion molecule-related/down-regulated by oncogenes", "protein_names_refseq": "Cdon homolog; cell adhesion molecule-related/down-regulated by oncogenes precursor; cell adhesion molecule-related/down-regulated by oncogenes; immunoglobulin superfamily member", "tax_id": 10116, "disease": "holoprosencephaly 11 (Disease Ontology:DOID:0110877)", "pathway": " (rno:50938); (R-RNO-525793); (R-RNO-5632681)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21802063;9214393", "class_list": "", "function": "Together with BOC, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:21802063). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (By similarity). ShhN is then directly transferred to patched receptor by GAS1 (By similarity). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (By similarity). Required for response to NTN3 and activation of NFATC3 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001708 cell fate specification;GO:0010172 embryonic body morphogenesis;GO:0014816 skeletal muscle satellite cell differentiation;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0060059 embryonic retina morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35158-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30994-1", "uniprot_id": [ { "id": "5HT2B_RAT", "url": "https://www.uniprot.org/uniprot/P30994", "type": "external" } ], "mass": 53652.0, "length": 479, "protein_name": "5-hydroxytryptamine receptor 2B", "gene_name": "Htr2b", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 2B", "refseq_ac": [ { "id": "NP_058946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058946", "type": "external" } ], "gene_names_uniprotkb": "Htr2b; Srl", "gene_names_refseq": "5-HT-2B; 5-HT-2F; 5-HT2B; Htr2b", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT-2F; 5-HT2B; Serotonin receptor 2B; Stomach fundus serotonin receptor", "protein_names_refseq": "5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine receptor 2B; serotonin receptor 2B; stomach fundus serotonin receptor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); brain infarction (Disease Ontology:DOID:3454); heart valve disease (Disease Ontology:DOID:4079); congestive heart failure (Disease Ontology:DOID:6000); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:29581); (R-RNO-390666); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1331748;1505525;22525520;29384698;32504811;37747614;38596485", "class_list": "", "function": "5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A))., [RefSeq, PubMed]; Cross-talk inhibition occurs between 5-HT2B and 5-HT7 receptors in phrenic motor facilitation via NADPH oxidase and PKA pathway., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1331748, PubMed:1505525). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:22525520). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:1331748, PubMed:1505525). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (By similarity). May play a role in the perception of pain (PubMed:22525520). Plays a role in the regulation of behavior, including impulsive behavior (By similarity). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (By similarity). Protects cardiomyocytes against apoptosis (By similarity). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (By similarity). Plays a role in vasoconstriction (By similarity). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (By similarity). Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Htr2b Promotes M1 Microglia Polarization and Neuroinflammation after Spinal Cord Injury via Inhibition of Neuregulin-1/ErbB Signaling., [RefSeq, PubMed]; Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9QW44", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035733 hepatic stellate cell activation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P30994-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZH4-1", "uniprot_id": [ { "id": "AAKB2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZH4", "type": "external" } ], "mass": 30227.0, "length": 271, "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "Prkab2", "organism": "Rat", "refseq_name": "5'-AMP-activated protein kinase subunit beta-2", "refseq_ac": [ { "id": "NP_072149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072149", "type": "external" } ], "gene_names_uniprotkb": "Prkab2", "gene_names_refseq": "Prkab2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2", "protein_names_refseq": "5'-AMP-activated protein kinase subunit beta-2; AMP-activated protein kinase beta-2 regulatory subunit; AMPK beta-2 chain; AMPK subunit beta-2; protein kinase, AMP-activated, beta 2 non-catalytic subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:64562); (R-RNO-1632852); (R-RNO-163680); (R-RNO-200425); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6804756); (R-RNO-9931269)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10544261;21460634;22673903;27099349;31189568", "class_list": "", "function": "In rat skeletal muscle, beta2-AMPK is not associated with glycogen and that activation of AMPK by muscle contraction does not dephosphorylate beta2-AMPK., [RefSeq, PubMed]; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data indicate that increased expression of AMPKbeta2 is an important feature of efficient adipogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006633 fatty acid biosynthetic process;GO:0031669 cellular response to nutrient levels;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QZH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70248-1", "uniprot_id": [ { "id": "APBA3_RAT", "url": "https://www.uniprot.org/uniprot/O70248", "type": "external" } ], "mass": 60882.0, "length": 569, "protein_name": "Amyloid-beta A4 precursor protein-binding family A member 3", "gene_name": "Apba3", "organism": "Rat", "refseq_name": "amyloid-beta A4 precursor protein-binding family A member 3", "refseq_ac": [ { "id": "NP_113969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113969", "type": "external" } ], "gene_names_uniprotkb": "Apba3; Mint3", "gene_names_refseq": "Apba3; Mint3", "protein_names_uniprotkb": "Amyloid-beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Mint-3; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3", "protein_names_refseq": "adapter protein X11gamma; amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2); amyloid-beta A4 precursor protein-binding family A member 3; mint-3; neuron-specific X11L2 protein; neuronal Munc18-1-interacting protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:83611)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;24867948;9860131", "class_list": "", "function": "FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells., [RefSeq, PubMed]; May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1WBQ3", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0015031 protein transport;GO:0007268 chemical synaptic transmission;GO:0043086 negative regulation of catalytic activity;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70248-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04757-1", "uniprot_id": [ { "id": "ACHA3_RAT", "url": "https://www.uniprot.org/uniprot/P04757", "type": "external" } ], "mass": 56998.0, "length": 499, "protein_name": "Neuronal acetylcholine receptor subunit alpha-3", "gene_name": "Chrna3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chrna3; Acra3", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); obsessive-compulsive disorder (Disease Ontology:DOID:10933); opioid abuse (Disease Ontology:DOID:11206); sciatic neuropathy (Disease Ontology:DOID:11446); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); vascular dementia (Disease Ontology:DOID:8725); substance dependence (Disease Ontology:DOID:9973); drug dependence (Disease Ontology:DOID:9974); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25101); (R-RNO-629587); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10465681;15609996;15929983;16641100;16964981;19474315;22250215;22561751;2444984;26265139;3753746;8144606", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:22250215, PubMed:22561751). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 (PubMed:22561751). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (PubMed:22561751). CHRNA3:CHRNB4 also plays an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (PubMed:22561751). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (PubMed:22250215)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030425 dendrite", "go_biological_process": "GO:0034465 response to carbon monoxide;GO:0006940 regulation of smooth muscle contraction;GO:0007165 signal transduction;GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0007271 synaptic transmission, cholinergic", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P04757-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04797-1", "uniprot_id": [ { "id": "G3P_RAT", "url": "https://www.uniprot.org/uniprot/P04797", "type": "external" } ], "mass": 35828.0, "length": 333, "protein_name": "Glyceraldehyde-3-phosphate dehydrogenase", "gene_name": "Gapdh; LOC134480898; Mir100hgl", "organism": "Rat", "refseq_name": "glyceraldehyde-3-phosphate dehydrogenase", "refseq_ac": [ { "id": "NP_058704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058704", "type": "external" } ], "gene_names_uniprotkb": "Gapdh; LOC134480898; Mir100hgl; Gapdhl3; Gapd; LOC134480667; LOC134480898; Mir100hgl", "gene_names_refseq": "BARS-38; Gapdh; Gapd", "protein_names_uniprotkb": "Glyceraldehyde-3-phosphate dehydrogenase; 1.2.1.12; 2.6.99.-; 38 kDa BFA-dependent ADP-ribosylation substrate; BARS-38; GAPDH; Peptidyl-cysteine S-nitrosylase GAPDH", "protein_names_refseq": "38 kDa BFA-dependent ADP-ribosylation substrate; glyceraldehyde-3-phosphate dehydrogenase; peptidyl-cysteine S-nitrosylase GAPDH", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spinocerebellar ataxia 37 (Disease Ontology:DOID:0050984); brain glioma (Disease Ontology:DOID:0060108); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); middle cerebral artery infarction (Disease Ontology:DOID:3525); diabetic retinopathy (Disease Ontology:DOID:8947); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:134480898); (rno:24383)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "10424669;1281150;14985449;15240697;15312048;15951807;17934141;19022411;19607794;20972425;2413848;29393594;2987824;2987855;32875725;33546324;34502162;3585333;37863305;38843836;6548307;8626764", "class_list": "", "function": "Catalyzes the conversion of D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:17934141). Also shows nitrosylase activity, thereby playing a role in nuclear functions (PubMed:15951807, PubMed:20972425). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (PubMed:15312048). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis (PubMed:10424669, PubMed:15951807, PubMed:20972425). Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (PubMed:15951807, PubMed:20972425)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress. Publication Status: Online-Only, [RefSeq, PubMed]; Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in autophagy activation following subarachnoid hemorrhage., [RefSeq, PubMed]; The combination of hprt and gapdh is the best compound reference genes in the fetal rat hippocampus., [RefSeq, PubMed]; This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein was originally identified as a key glycolytic enzyme that converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Subsequent studies in human and mouse have assigned a variety of additional functions to the protein including nitrosylation of nuclear proteins. Many pseudogenes similar to this locus are found throughout the rat genome. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 15, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P09328;Q5M916;Q9QWU4", "ec_number_list": [ { "id": "1.2.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0045471 response to ethanol;GO:0051402 neuron apoptotic process;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0001819 positive regulation of cytokine production;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P04797-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07154-1", "uniprot_id": [ { "id": "CATL1_RAT", "url": "https://www.uniprot.org/uniprot/P07154", "type": "external" } ], "mass": 37660.0, "length": 334, "protein_name": "Procathepsin L", "gene_name": "Ctsl", "organism": "Rat", "refseq_name": "procathepsin L preproprotein", "refseq_ac": [ { "id": "NP_037288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037288", "type": "external" } ], "gene_names_uniprotkb": "Ctsl; Ctsl1", "gene_names_refseq": "CATHL; CatL; Ctsl1; Ctsl", "protein_names_uniprotkb": "Procathepsin L; 3.4.22.15; CP-2; Cathepsin L1; Cyclic protein 2; MEP; Major excreted protein", "protein_names_refseq": "CP-2; MEP; cathepsin L1; cyclic protein 2; major excreted protein; procathepsin L preproprotein; procathepsin L", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); otitis media (Disease Ontology:DOID:10754); nephrotic syndrome (Disease Ontology:DOID:1184); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25697); (R-RNO-1442490); (R-RNO-1679131); (R-RNO-2022090); (R-RNO-2024096); (R-RNO-2132295); (R-RNO-8939242); (R-RNO-9766229); (R-RNO-9958810)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "10699763;11356678;1791830;2599113;26479776;30052474;31302164;31444477;3402618;3666143;38330925;7777858", "class_list": "", "function": "Cathepsin L induces apoptosis in rotenone-treated PC-12 cells via activation of B-Myb protein., [RefSeq, PubMed]; In contrast to the weak levels of cathepsin L in normal glomeruli, on days 4 and 8, strong immunostaining was detected in almost all podocytes when proteinuria and pathological changes of the podocytes developed. Cathepsin L was reduced after day 28, but remained in a focal and segmental manner. Cystatin B, an intracellular inhibitor, was not detected in podocytes., [RefSeq, PubMed]; Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL Pathway., [RefSeq, PubMed]; The results revealed that cathepsin B and L activity is required for maintenance of a fully differentiated state of thyrocytes featuring Taar1-bearing primary cilia., [RefSeq, PubMed]; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 (By similarity). Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (PubMed:7777858)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QV07", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.22.42", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.42", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.23.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.34", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" } ], "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004175 endopeptidase activity;GO:0046872 metal ion binding;GO:0005518 collagen binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0051384 response to glucocorticoid;GO:0008584 male gonad development;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07154-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08290-1", "uniprot_id": [ { "id": "ASGR2_RAT", "url": "https://www.uniprot.org/uniprot/P08290", "type": "external" } ], "mass": 35027.0, "length": 301, "protein_name": "Asialoglycoprotein receptor 2", "gene_name": "Asgr2", "organism": "Rat", "refseq_name": "asialoglycoprotein receptor 2", "refseq_ac": [ { "id": "NP_058885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058885", "type": "external" } ], "gene_names_uniprotkb": "Asgr2; Asgr-2", "gene_names_refseq": "Asgr2", "protein_names_uniprotkb": "Asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; HL-2; Hepatic lectin R2/3; rHL-2", "protein_names_refseq": "ASGP-R 2; ASGPR 2; HL-2; RHL-2; asialoglycoprotein receptor 2; hepatic lectin 2, RHL2; hepatic lectin R2/3", "tax_id": 10116, "disease": "", "pathway": " (rno:29403); (R-RNO-446203)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;3234178;3597443;3600647;6319386;8943311", "class_list": "", "function": "Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5M8C9", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0042806 fucose binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response;GO:0055088 lipid homeostasis;GO:0031647 regulation of protein stability;GO:0009100 glycoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08290-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08592-1", "uniprot_id": [ { "id": "A4_RAT", "url": "https://www.uniprot.org/uniprot/P08592", "type": "external" } ], "mass": 86704.0, "length": 770, "protein_name": "Amyloid-beta precursor protein", "gene_name": "App", "organism": "Rat", "refseq_name": "amyloid-beta precursor protein precursor", "refseq_ac": [ { "id": "NP_062161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062161", "type": "external" } ], "gene_names_uniprotkb": "App; A4; AD1", "gene_names_refseq": "Abeta; App", "protein_names_uniprotkb": "Amyloid-beta precursor protein; ABPP; AG; APP; Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloidogenic glycoprotein; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59)", "protein_names_refseq": "ABPP; AG; alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid precursor protein; amyloid-beta precursor protein precursor; amyloidogenic glycoprotein; beta-amyloid precursor protein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); diabetic encephalopathy (Disease Ontology:DOID:0050850); APP-related cerebral amyloid angiopathy (Disease Ontology:DOID:0070028); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); iron deficiency anemia (Disease Ontology:DOID:11758); alcoholic hepatitis (Disease Ontology:DOID:12351); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); middle cerebral artery infarction (Disease Ontology:DOID:3525); periodontitis (Disease Ontology:DOID:824); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54226); (R-RNO-114608); (R-RNO-3000178); (R-RNO-381426); (R-RNO-416476); (R-RNO-418594); (R-RNO-432720); (R-RNO-444473); (R-RNO-445989); (R-RNO-879415); (R-RNO-8957275); (R-RNO-933542); (R-RNO-9609523); (R-RNO-9769739); (R-RNO-9837999)", "pathway_count": 15, "publication_count": 28, "publication_id_list": "10024358;10329382;10341243;10386999;10413512;10936190;11479316;11483588;11959460;1673681;22673903;22847417;23011729;26479776;2648331;2900758;2968652;37256589;38527407;39159732;7737970;7744833;7913895;7982489;8624099;8996834;9085254;9930726", "class_list": "", "function": "Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron. Rat and mouse amyloid-beta peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Amyloid-beta protein 42 may activate mononuclear phagocytes in the brain and elicits inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Also binds GPC1 in lipid rafts (By similarity)., [UniProtKB]; Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain., [UniProtKB]; Evaluation of hippocampal arylalkylamine N-acetyltransferase activity in amyloid-beta neurotoxicity. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o)-alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity). By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons (By similarity). May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Galectin-9 and Tim-3 are upregulated in response to microglial activation induced by the peptide Amyloid-beta (25-35)., [RefSeq, PubMed]; Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Abeta burden in early Alzheimer's disease models., [RefSeq, PubMed]; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q547B7", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001774 microglial cell activation;GO:0001967 suckling behavior;GO:0002265 astrocyte activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P08592-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6P5-1", "uniprot_id": [ { "id": "ARG28_RAT", "url": "https://www.uniprot.org/uniprot/P0C6P5", "type": "external" } ], "mass": 190757.0, "length": 1700, "protein_name": "Rho guanine nucleotide exchange factor 28", "gene_name": "Arhgef28", "organism": "Rat", "refseq_name": "rho guanine nucleotide exchange factor 28", "refseq_ac": [ { "id": "NP_001401994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401994", "type": "external" } ], "gene_names_uniprotkb": "Arhgef28; Rgnef", "gene_names_refseq": "Arhgef28; Rgnef", "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 28; 190 kDa guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor; p190-RhoGEF; p190RhoGEF", "protein_names_refseq": "190 kDa guanine nucleotide exchange factor; Rho guanine nucleotide exchange factor (GEF) 28; Rho-guanine nucleotide exchange factor; p190-RhoGEF; p190RhoGEF; rho guanine nucleotide exchange factor 28", "tax_id": 10116, "disease": "", "pathway": " (rno:361882); (R-RNO-3928662); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "11435431;12215442;12702722;14499478;22673903", "class_list": "", "function": "Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0060052 neurofilament cytoskeleton organization;GO:0021955 central nervous system neuron axonogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C6P5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP30-1", "uniprot_id": [ { "id": "CALM2_RAT", "url": "https://www.uniprot.org/uniprot/P0DP30", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-2", "gene_name": "Calm2", "organism": "Rat", "refseq_name": "calmodulin-2", "refseq_ac": [ { "id": "NP_059022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059022", "type": "external" } ], "gene_names_uniprotkb": "Calm2; CaMII; Cam2; Camb", "gene_names_refseq": "CaMII; Calm2; Cam2; Camb; Cam", "protein_names_uniprotkb": "Calmodulin-2", "protein_names_refseq": "calmodulin 2 (phosphorylase kinase, delta); calmodulin-2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); long QT syndrome 15 (Disease Ontology:DOID:0110656); major depressive disorder (Disease Ontology:DOID:1470); cancer (Disease Ontology:DOID:162); substance abuse (Disease Ontology:DOID:302)", "pathway": " (rno:24242); (rno:24244); (rno:50663)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "12392717;18056528;201628;22673903;2445749;2527998;28153703;30225708;3037336;31429119;8576129", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2., [UniProtKB, UniProtKB]; Epac1/Epac2 and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy., [RefSeq, PubMed]; Higher occupancy of Calm2 and Calm3 promoters by NFATc2 and increased expression of these genes in response to NFATc2 silencing were demonstrated in PMCA2 and PMCA3-reduced lines., [RefSeq, PubMed]; LncRNA GAS5 regulates myocardial infarction by targeting the miR-525-5p/CALM2 axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62161;P70667;P99014;Q61379;Q61380", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P0DP30-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DP31-1", "uniprot_id": [ { "id": "CALM3_RAT", "url": "https://www.uniprot.org/uniprot/P0DP31", "type": "external" } ], "mass": 16838.0, "length": 149, "protein_name": "Calmodulin-3", "gene_name": "Calm3", "organism": "Rat", "refseq_name": "calmodulin-3", "refseq_ac": [ { "id": "NP_036650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036650", "type": "external" } ], "gene_names_uniprotkb": "Calm3; CaMIII; Cam3; Camc", "gene_names_refseq": "CaMIII; Calm3; Cam3; Camc; RNCAMIII", "protein_names_uniprotkb": "Calmodulin-3", "protein_names_refseq": "Calmodulin III; caM; calmodulin-3", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); long QT syndrome 16 (Disease Ontology:DOID:0070533); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:24242); (rno:24244); (rno:50663); (R-RNO-111932); (R-RNO-111933); (R-RNO-111957); (R-RNO-114608); (R-RNO-1474151); (R-RNO-163615); (R-RNO-1855204); (R-RNO-2025928); (R-RNO-203615); (R-RNO-2514859); (R-RNO-2672351); (R-RNO-2871809); (R-RNO-4086398); (R-RNO-418359); (R-RNO-425561); (R-RNO-438066); (R-RNO-442729); (R-RNO-445355); (R-RNO-451308); (R-RNO-5218920); (R-RNO-5578775); (R-RNO-5607763); (R-RNO-5626467); (R-RNO-5627123); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-70221); (R-RNO-8876725); (R-RNO-9009391); (R-RNO-936837); (R-RNO-9619229); (R-RNO-9648002); (R-RNO-9856530)", "pathway_count": 36, "publication_count": 9, "publication_id_list": "12392717;18056528;201628;22673903;2527998;28153703;28765142;2885164;8576129", "class_list": "", "function": "Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis., [UniProtKB, UniProtKB]; Higher occupancy of Calm2 and Calm3 promoters by NFATc2 and increased expression of these genes in response to NFATc2 silencing were demonstrated in PMCA2 and PMCA3-reduced lines., [RefSeq, PubMed]; Results identify the retained intron as a critical element in recruiting Stau2, which then allows for the localization of Calm3L mRNA to distal dendrites, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02593;P62161;P70667;P99014;Q61379;Q61380", "ec_number_list": [], "go_molecular_function": "GO:0031800 type 3 metabotropic glutamate receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:1901842 negative regulation of high voltage-gated calcium channel activity;GO:0090151 establishment of protein localization to mitochondrial membrane;GO:0051592 response to calcium ion;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P0DP31-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11505-3", "uniprot_id": [ { "id": "AT2B1_RAT", "url": "https://www.uniprot.org/uniprot/P11505", "type": "external" } ], "mass": 134693.0, "length": 1220, "protein_name": "Plasma membrane calcium-transporting ATPase 1", "gene_name": "Atp2b1", "organism": "Rat", "refseq_name": "plasma membrane calcium-transporting ATPase 1 isoform 3", "refseq_ac": [ { "id": "NP_445763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445763", "type": "external" } ], "gene_names_uniprotkb": "Atp2b1", "gene_names_refseq": "Atp2b1; Pmca1a; Pmca1b; Pmca1c", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 1; 7.2.2.10; PMCA1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1", "protein_names_refseq": "ATPase, Ca++ transporting, plasma membrane 1; PMCA1; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 1 isoform 3; plasma membrane calcium-transporting ATPase 1", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); autosomal dominant intellectual developmental disorder 66 (Disease Ontology:DOID:0061039); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gestational diabetes (Disease Ontology:DOID:11714); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29598); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10858669;16803870;21454685;22673903;2837461;38843836;8428948", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63442;Q9R1L7", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0003407 neural retina development;GO:0006874 intracellular calcium ion homeostasis;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P11505-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12390-1", "uniprot_id": [ { "id": "ACHB2_RAT", "url": "https://www.uniprot.org/uniprot/P12390", "type": "external" } ], "mass": 56909.0, "length": 500, "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "Chrnb2", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit beta-2 precursor", "refseq_ac": [ { "id": "NP_062170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062170", "type": "external" } ], "gene_names_uniprotkb": "Chrnb2; Acrb2", "gene_names_refseq": "Chrnb2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-2; N-alpha 1; Neuronal acetylcholine receptor non-alpha-1 chain", "protein_names_refseq": "N-alpha 1; cholinergic receptor nicotinic beta polypeptide 2; cholinergic receptor, nicotinic beta 2; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); cholinergic receptor, nicotinic, beta subunit 2; neuronal acetylcholine receptor non-alpha-1 chain; neuronal acetylcholine receptor subunit beta-2 precursor; neuronal acetylcholine receptor subunit beta-2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant nocturnal frontal lobe epilepsy (Disease Ontology:DOID:0060681); autosomal dominant nocturnal frontal lobe epilepsy 3 (Disease Ontology:DOID:0060684); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:54239); (R-RNO-629587); (R-RNO-629594); (R-RNO-629597)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10465681;15609996;15929983;16964981;21325521;2444984;26858154;27721068;28666811;3272154;9882698", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:10465681). CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits (PubMed:10465681). Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation (By similarity). Heteropentameric channels with CHRNA6 and CHRNA4 exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system. nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (PubMed:21325521). Also forms functional nAChRs with other subunits such as CHRNA7:CHRNB2, mainly expressed in basal forebrain cholinergic neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Findings indicate that alterations in expression of the alpha4beta2 subtype of nAChR may be involved in the molecular mechanism(s) underlying the cognitive deficit associated with vascular dementia, [RefSeq, PubMed]; Study shows that alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty, [RefSeq, PubMed]; The mechanism of interaction between [Upsilon4E]GID and the agonist binding pockets of the alpha4beta2 and the halpha7 receptors, and to estimate their relative binding affinities, was investigated., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53YK1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0042166 acetylcholine binding;GO:0044877 protein-containing complex binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0044853 plasma membrane raft;GO:0045202 synapse;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P12390-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14141-1", "uniprot_id": [ { "id": "CAH3_RAT", "url": "https://www.uniprot.org/uniprot/P14141", "type": "external" } ], "mass": 29431.0, "length": 260, "protein_name": "Carbonic anhydrase 3", "gene_name": "Ca3", "organism": "Rat", "refseq_name": "carbonic anhydrase 3", "refseq_ac": [ { "id": "NP_062165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062165", "type": "external" } ], "gene_names_uniprotkb": "Ca3; Car3", "gene_names_refseq": "Ca3; Car3", "protein_names_uniprotkb": "Carbonic anhydrase 3; 4.2.1.1; CA-III; Carbonate dehydratase III; Carbonic anhydrase III", "protein_names_refseq": "CA-III; carbonate dehydratase III; carbonic anhydrase 3; carbonic anhydrase III", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); alcohol-associated liver disease (Disease Ontology:DOID:0070658); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); lesion of sciatic nerve (Disease Ontology:DOID:12528); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:54232); (R-RNO-1475029)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10900145;11024467;14985449;15930751;1659965;1899179;22673903;25684186;2852973;28983629;29559661;34387844;34502162;35108454;8476041", "class_list": "", "function": "Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line., [RefSeq, PubMed]; Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation., [RefSeq, PubMed]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury., [RefSeq, PubMed]; These data clearly suggests that CAIII serves as an important antioxidant critical in protecting NP cells against oxidative stress-induced injury. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicated that, following denervation, changes in the expression of CAIII were associated with myofiber remodeling. Specifically, the change in the expression of CAIII reflected the conversion to type I myofibers, suggesting the importance of CAIII in resistance to fatigue in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54961;Q9QV77", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016791 phosphatase activity;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0097305 response to alcohol;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0003009 skeletal muscle contraction;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P14141-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14842-1", "uniprot_id": [ { "id": "5HT2A_RAT", "url": "https://www.uniprot.org/uniprot/P14842", "type": "external" } ], "mass": 52850.0, "length": 471, "protein_name": "5-hydroxytryptamine receptor 2A", "gene_name": "Htr2a", "organism": "Rat", "refseq_name": "5-hydroxytryptamine receptor 2A", "refseq_ac": [ { "id": "NP_058950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058950", "type": "external" } ], "gene_names_uniprotkb": "Htr2a; Htr2", "gene_names_refseq": "5-HT2A; 5Ht-2; Htr2a", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2; Serotonin receptor 2A", "protein_names_refseq": "5-HT-2A; 5-HT-2; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; serotonin 5HT-2 receptor; serotonin receptor 2A", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); obsessive-compulsive disorder (Disease Ontology:DOID:10933); pathological gambling (Disease Ontology:DOID:12399); bladder neck obstruction (Disease Ontology:DOID:13948); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); alcoholic psychosis (Disease Ontology:DOID:252); inflammatory and toxic neuropathy (Disease Ontology:DOID:2537); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); acute stress disorder (Disease Ontology:DOID:6088); cocaine abuse (Disease Ontology:DOID:809); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29595); (R-RNO-390666); (R-RNO-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11960784;1765383;2300586;2854054;38408524;38509093;38777263;39154826", "class_list": "", "function": "5-HT1A and 5-HT2A receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat., [RefSeq, PubMed]; G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:2300586, PubMed:2854054). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Affects neural activity, perception, cognition and mood (By similarity). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances (By similarity). Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety. Publication Status: Online-Only, [RefSeq, PubMed]; The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?, [RefSeq, PubMed]; The serotonin(5-HT)2A receptor is involved in the hypersensitivity of bladder afferent neurons in cyclophosphamide-induced cystitis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0045600 positive regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14842-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15650-1", "uniprot_id": [ { "id": "ACADL_RAT", "url": "https://www.uniprot.org/uniprot/P15650", "type": "external" } ], "mass": 47873.0, "length": 430, "protein_name": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acadl", "organism": "Rat", "refseq_name": "long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036951", "type": "external" } ], "gene_names_uniprotkb": "Acadl", "gene_names_refseq": "ACOADA; Acadl; LCAD", "protein_names_uniprotkb": "Long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.7; 1.3.8.8; LCAD; Medium-chain acyl-CoA dehydrogenase, mitochondrial", "protein_names_refseq": "Acyl Coenzyme A dehydrogenase, long chain; LCAD long chain acyl-CoA dehydrogenase; acetyl-Coenzyme A dehydrogenase, long-chain; acyl-Coenzyme A dehydrogenase, long-chain; long-chain acyl-CoA dehydrogenase; long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; long-chain specific acyl-CoA dehydrogenase, mitochondrial; medium-chain acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "very long chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080155)", "pathway": " (rno:25287); (R-RNO-77285); (R-RNO-77310)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15466478;22673903;26446791;27213235;2777793;29393594;34502162;3813556;3968063;8268228", "class_list": "", "function": "Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:3968063). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions (PubMed:3968063). Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production) (By similarity) (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase activity overlaps with that of ACADV and ACAD9, acting on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:15466478, PubMed:3968063). Can use (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate as substrate in vitro (which is not primarily used for energy but mainly beta-oxidized in the peroxisomes). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Plays a primary role in FAO in tissues where it is the main long-chain ACAD expressed. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase acts on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0009062 fatty acid catabolic process;GO:0009409 response to cold;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P15650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15651-1", "uniprot_id": [ { "id": "ACADS_RAT", "url": "https://www.uniprot.org/uniprot/P15651", "type": "external" } ], "mass": 44765.0, "length": 412, "protein_name": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "Acads", "organism": "Rat", "refseq_name": "short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_071957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071957", "type": "external" } ], "gene_names_uniprotkb": "Acads", "gene_names_refseq": "Acads; Scad", "protein_names_uniprotkb": "Short-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.1; Butyryl-CoA dehydrogenase; SCAD", "protein_names_refseq": "acetyl-Coenzyme A dehydrogenase, short chain; acyl-CoA dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; acyl-Coenzyme A dehydrogenase, short chain; butyryl-CoA dehydrogenase; short chain acyl-coenzyme A dehydrogenase; short-chain acyl-CoA dehydrogenase; short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; short-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "short chain acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0080154); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:64304); (R-RNO-77350); (R-RNO-77352)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11812788;25636810;25753319;26446791;26989860;27213235;2777793;36883465;3968063", "class_list": "", "function": "Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling., [RefSeq, PubMed]; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:3968063)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The down-regulated expression of SCAD in pathological cardiac hypertrophy may be responsible for 'the recapitulation of foetal energy metabolism'., [RefSeq, PubMed]; The phosphorylation of ERK1/2 inhibited the expression and activity of SCAD through the PPARalpha signaling pathway, which induced the development of pathological cardiomyocyte hypertrophy., [RefSeq, PubMed]; The role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis, is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0042594 response to starvation;GO:0051384 response to glucocorticoid;GO:0046359 butyrate catabolic process;GO:0046395 carboxylic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P15651-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15887-1", "uniprot_id": [ { "id": "ARRS_RAT", "url": "https://www.uniprot.org/uniprot/P15887", "type": "external" } ], "mass": 44950.0, "length": 403, "protein_name": "S-arrestin", "gene_name": "Sag", "organism": "Rat", "refseq_name": "S-arrestin", "refseq_ac": [ { "id": "NP_037155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037155", "type": "external" } ], "gene_names_uniprotkb": "Sag", "gene_names_refseq": "SAGMR; SANTI; Sag", "protein_names_uniprotkb": "S-arrestin; 48 kDa protein; Retinal S-antigen; Rod photoreceptor arrestin; S-AG", "protein_names_refseq": "48 kDa protein; S-AG; S-antigen; S-arrestin; retina and pineal gland (arrestin); retinal S-antigen; rod photoreceptor arrestin", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); retinitis pigmentosa 96 (Disease Ontology:DOID:0061104); lupus nephritis (Disease Ontology:DOID:0080162); graft-versus-host disease (Disease Ontology:DOID:0081267); retinitis pigmentosa 47 (Disease Ontology:DOID:0110369); Oguchi disease-1 (Disease Ontology:DOID:0110712); immunodeficiency 20 (Disease Ontology:DOID:0111941); lymphoid leukemia (Disease Ontology:DOID:1037); allergic disease (Disease Ontology:DOID:1205); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); polyneuropathy (Disease Ontology:DOID:1389); thrombocytopenia due to platelet alloimmunization (Disease Ontology:DOID:1587); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); lymphopenia (Disease Ontology:DOID:614); myositis (Disease Ontology:DOID:633); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); arthritis (Disease Ontology:DOID:848); hereditary night blindness (Disease Ontology:DOID:8498); Crohn's disease (Disease Ontology:DOID:8778); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25539); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16641100;1712808;2213004;2373176;2714438;8157981", "class_list": "", "function": "Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G proteins by competing with G proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0051219 phosphoprotein binding;GO:0030507 spectrin binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0016020 membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007165 signal transduction;GO:0007600 sensory perception;GO:0002031 G protein-coupled receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P15887-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22909-1", "uniprot_id": [ { "id": "ADA2A_RAT", "url": "https://www.uniprot.org/uniprot/P22909", "type": "external" } ], "mass": 50630.0, "length": 465, "protein_name": "Alpha-2A adrenergic receptor", "gene_name": "Adra2a", "organism": "Rat", "refseq_name": "alpha-2A adrenergic receptor", "refseq_ac": [ { "id": "NP_036871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036871", "type": "external" } ], "gene_names_uniprotkb": "Adra2a", "gene_names_refseq": "Adra2a; CA2-47; RATRG20; RG20", "protein_names_uniprotkb": "Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR; Alpha-2D adrenergic receptor; CA2-47", "protein_names_refseq": "adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR; alpha-2D adrenergic receptor", "tax_id": 10116, "disease": "familial partial lipodystrophy (Disease Ontology:DOID:0050440); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); substance abuse (Disease Ontology:DOID:302); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25083); (R-RNO-390696); (R-RNO-392023); (R-RNO-400042); (R-RNO-418594); (R-RNO-418597); (R-RNO-5683826)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "15213003;1645350;2177834;22673903;30264294;30929926;31542234;37548252;7623790", "class_list": "", "function": "Adra2a signaling is impaired in the cardiomyocytes of spontaneously hypertensive rats starting from 2 months old., [RefSeq, PubMed]; Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity)., [UniProtKB, UniProtKB, PubMed]; Chronic testosterone influences impulsivity possibly via hyperactive alpha-2A adrenergic receptor-PKA signaling axis., [RefSeq, PubMed]; Expression and localization of alpha2A-adrenergic receptor in the rat post-natal developing cochlea. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that alpha-2A adrenergic receptor (alpha2-adrenoceptors) in the prelimbic cortex (PrL) are involved in the regulation of anxiety-like behaviors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M0R9R3", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0032795 heterotrimeric G-protein binding;GO:0004938 alpha2-adrenergic receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0097305 response to alcohol;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26770-1", "uniprot_id": [ { "id": "ADCY4_RAT", "url": "https://www.uniprot.org/uniprot/P26770", "type": "external" } ], "mass": 118799.0, "length": 1064, "protein_name": "Adenylate cyclase type 4", "gene_name": "Adcy4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Adcy4", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylate cyclase type 4; 4.6.1.1; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1946437;22673903", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26770-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29067-1", "uniprot_id": [ { "id": "ARRB2_RAT", "url": "https://www.uniprot.org/uniprot/P29067", "type": "external" } ], "mass": 46340.0, "length": 410, "protein_name": "Beta-arrestin-2", "gene_name": "Arrb2", "organism": "Rat", "refseq_name": "beta-arrestin-2", "refseq_ac": [ { "id": "NP_037043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037043", "type": "external" } ], "gene_names_uniprotkb": "Arrb2", "gene_names_refseq": "Arrb2; BARRES", "protein_names_uniprotkb": "Beta-arrestin-2; Arrestin beta-2", "protein_names_refseq": "beta-arrestin-2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); sensorineural hearing loss (Disease Ontology:DOID:10003); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); drug psychosis (Disease Ontology:DOID:1742); opiate dependence (Disease Ontology:DOID:2559); glioblastoma (Disease Ontology:DOID:3068); brain infarction (Disease Ontology:DOID:3454); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); type 2 diabetes mellitus (Disease Ontology:DOID:9352); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25388); (R-RNO-418555); (R-RNO-456926); (R-RNO-5099900); (R-RNO-5674135); (R-RNO-5689880); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9839389)", "pathway_count": 9, "publication_count": 32, "publication_id_list": "10097102;10747877;10753943;10770944;10852825;11090355;11226259;11448957;11588219;11777902;11777907;12186555;12464600;12944399;14500724;1517224;15173580;15618519;15699045;15738310;15878855;16051150;17666399;18006496;18408005;19055777;22810587;23886940;29393594;8308033;9767391;9822622", "class_list": "", "function": "Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in IL8-mediated granule release in neutrophils (By similarity). Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in both localization to primary cilium and endocytosis of smoothened (SMO) in a GRK2-dependent process. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 16, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0001934 positive regulation of protein phosphorylation;GO:0006897 endocytosis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "P29067-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38918-1", "uniprot_id": [ { "id": "ARK73_RAT", "url": "https://www.uniprot.org/uniprot/P38918", "type": "external" } ], "mass": 36747.0, "length": 327, "protein_name": "Aldo-keto reductase family 7 member A3", "gene_name": "Akr7a3", "organism": "Rat", "refseq_name": "aldo-keto reductase family 7 member A3", "refseq_ac": [ { "id": "NP_037347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037347", "type": "external" } ], "gene_names_uniprotkb": "Akr7a3; Afar; Akr7a1", "gene_names_refseq": "Afar; Akr7a1; Akr7a3", "protein_names_uniprotkb": "Aldo-keto reductase family 7 member A3; 1.1.1.2; AFB1-AR; Aflatoxin B1 aldehyde reductase member 1; Aflatoxin B1 aldehyde reductase member 3; rAFAR1", "protein_names_refseq": "AFB1-AR; aflatoxin B1 aldehyde reductase member 1; aflatoxin B1 aldehyde reductase member 3; aldo-keto reductase family 7 member A3; aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase); rAFAR1", "tax_id": 10116, "disease": "", "pathway": " (rno:26760); (R-RNO-5423646)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10383892;11409944;11839745;12071861;12727802;22673903;29383608;8234296;8395332", "class_list": "", "function": "A dimeric member of the aldo-keto reductase superfamily; structure resolved to 1.38A resolution (AKR7A1, aflatoxin dialdehyde reductase AKR7A1), [RefSeq, PubMed]; Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity., [UniProtKB, PubMed, PubMed]; Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples., [RefSeq, PubMed]; Structure and chromosomal localization and idetification of antioxidant response elements in the gene promoter, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB7;Q68FZ3;Q9QX16", "ec_number_list": [ { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.n11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n11", "type": "external" } ], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0016614 oxidoreductase activity, acting on CH-OH group of donors;GO:0042802 identical protein binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0070401 NADP+ binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0046223 aflatoxin catabolic process;GO:0046222 aflatoxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P38918-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43145-1", "uniprot_id": [ { "id": "ADML_RAT", "url": "https://www.uniprot.org/uniprot/P43145", "type": "external" } ], "mass": 20636.0, "length": 185, "protein_name": "Pro-adrenomedullin", "gene_name": "Adm", "organism": "Rat", "refseq_name": "pro-adrenomedullin precursor", "refseq_ac": [ { "id": "NP_036847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036847", "type": "external" } ], "gene_names_uniprotkb": "Adm", "gene_names_refseq": "Adm; Ap; H39316; RATAP", "protein_names_uniprotkb": "Pro-adrenomedullin; PAMP; ProAM N-terminal 20 peptide; ProAM-N20", "protein_names_refseq": "pro-adrenomedullin precursor; pro-adrenomedullin", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); malignant hypertension (Disease Ontology:DOID:10824); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); obstructive jaundice (Disease Ontology:DOID:13603); toxic shock syndrome (Disease Ontology:DOID:14115); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); peripheral vascular disease (Disease Ontology:DOID:341); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); insulinoma (Disease Ontology:DOID:3892); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); abdominal aortic aneurysm (Disease Ontology:DOID:7693); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25026); (R-RNO-419812); (R-RNO-9856530)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "26479776;27184601;27737007;30366012;31489964;34978596;7690563;8524787", "class_list": "", "function": "ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex., [UniProtKB, UniProtKB]; Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes., [RefSeq, PubMed]; Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:7690563). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed]; MicroRNA-26b inhibits oligodendrocyte precursor cell differentiation by targeting adrenomedullin in spinal cord injury., [RefSeq, PubMed]; Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Acts as a ligand for Mrgprb2 receptor in mast cells., [UniProtKB, UniProtKB]; Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that the increased Adrenomedullin bioactivity induced mechanical allodynia., [RefSeq, PubMed]; Study suggests that the increased adrenomedullin receptor signaling mediated the many, but not all, tumor necrosis factor-alpha-induced activities, contributing to peripheral sensitization in neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031700 adrenomedullin receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0001570 vasculogenesis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P43145-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47728-1", "uniprot_id": [ { "id": "CALB2_RAT", "url": "https://www.uniprot.org/uniprot/P47728", "type": "external" } ], "mass": 31405.0, "length": 271, "protein_name": "Calretinin", "gene_name": "Calb2", "organism": "Rat", "refseq_name": "calretinin", "refseq_ac": [ { "id": "NP_446440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446440", "type": "external" } ], "gene_names_uniprotkb": "Calb2", "gene_names_refseq": "Calb2", "protein_names_uniprotkb": "Calretinin; CR", "protein_names_refseq": "CR; calretinin", "tax_id": 10116, "disease": "", "pathway": " (rno:117059)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14664811;1988053;22673903;25730969;25813826;33040447;7918640", "class_list": "", "function": "A role for calreticulin in functioning of mitochondrial ATP-dependent potassium channel, [RefSeq, PubMed]; Calcium-binding protein involved in calcium homeostasis and signal transduction. It plays a critical role in buffering intracellular calcium levels and modulating calcium-dependent signaling pathways. Predominantly expressed in specific neuronal populations, influences synaptic plasticity and neuronal excitability, contributing to learning and memory (By similarity). During embryonic development, it facilitates neuronal differentiation and maturation (PubMed:14664811)., [UniProtKB, PubMed, UniProtKB]; Expression of calbindin and calretinin in the dorsomedial and ventromedial hypothalamic nuclei during aging., [RefSeq, PubMed]; Quantitative analysis of the transient changes in calretinin expression by hybridochemistry within neuronal cell populations in the hippocampus of a beta amyloid-treated rat model of Alzheimer's disease and their correlation with endocannabinoid increase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043195 terminal bouton", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0048167 regulation of synaptic plasticity;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47728-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49192-1", "uniprot_id": [ { "id": "CART_RAT", "url": "https://www.uniprot.org/uniprot/P49192", "type": "external" } ], "mass": 14140.0, "length": 129, "protein_name": "Cocaine- and amphetamine-regulated transcript protein", "gene_name": "Cartpt", "organism": "Rat", "refseq_name": "cocaine- and amphetamine-regulated transcript protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_058806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058806", "type": "external" } ], "gene_names_uniprotkb": "Cartpt; Cart", "gene_names_refseq": "Cartpt; Cart", "protein_names_uniprotkb": "Cocaine- and amphetamine-regulated transcript protein", "protein_names_refseq": "cocaine and amphetamine regulated transcript; cocaine- and amphetamine-regulated transcript protein isoform 1 precursor; cocaine- and amphetamine-regulated transcript protein", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); amnestic disorder (Disease Ontology:DOID:10914); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); cerebral infarction (Disease Ontology:DOID:3526); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29131)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "22673903;33098940;34043767;36539163;37859350;7891182;9654146", "class_list": "", "function": "Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats., [RefSeq, PubMed]; CART decreases islet blood flow, but has no effect on total pancreatic blood flow and glucose tolerance in anesthetized rats., [RefSeq, PubMed]; Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise. Review article, [RefSeq, PubMed]; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030141 secretory granule;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0090325 regulation of locomotion involved in locomotory behavior;GO:0035106 operant conditioning;GO:1903999 negative regulation of eating behavior;GO:0006171 cAMP biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49192-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50430-1", "uniprot_id": [ { "id": "ARSB_RAT", "url": "https://www.uniprot.org/uniprot/P50430", "type": "external" } ], "mass": 58959.0, "length": 528, "protein_name": "Arylsulfatase B", "gene_name": "Arsb", "organism": "Rat", "refseq_name": "arylsulfatase B precursor", "refseq_ac": [ { "id": "NP_254278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_254278", "type": "external" } ], "gene_names_uniprotkb": "Arsb", "gene_names_refseq": "Arsb", "protein_names_uniprotkb": "Arylsulfatase B; 3.1.6.12; ASB; G4S; N-acetylgalactosamine-4-sulfatase", "protein_names_refseq": "ASB; Arylsulfatase B (MPS VI); G4S; N-acetylgalactosamine-4-sulfatase; arylsulfatase B precursor", "tax_id": 10116, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypomyelinating leukodystrophy 20 (Disease Ontology:DOID:0112153); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); multiple sclerosis (Disease Ontology:DOID:2377); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:25227); (R-RNO-1663150); (R-RNO-2024101); (R-RNO-6798695); (R-RNO-9840310)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "16174644;19536613;24311516;8575749", "class_list": "", "function": "Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:24311516). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (PubMed:24311516). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q32KK1", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", 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"https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0043890 N-acetylgalactosamine-6-sulfatase activity;GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0003943 N-acetylgalactosamine-4-sulfatase activity;GO:0008484 sulfuric ester hydrolase activity", "go_cellular_component": "GO:0009986 cell surface;GO:0005764 lysosome", "go_biological_process": "GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0007584 response to nutrient;GO:0010976 positive regulation of neuron projection development;GO:0006914 autophagy;GO:0009268 response to pH", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50430-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54287-1", "uniprot_id": [ { "id": "CACB3_RAT", "url": "https://www.uniprot.org/uniprot/P54287", "type": "external" } ], "mass": 54564.0, "length": 484, "protein_name": "Voltage-dependent L-type calcium channel subunit beta-3", "gene_name": "Cacnb3", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit beta-3", "refseq_ac": [ { "id": "NP_036960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036960", "type": "external" } ], "gene_names_uniprotkb": "Cacnb3; Cacnlb3", "gene_names_refseq": "CACH3B; Cacnb3", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit beta-3; CAB3; Calcium channel voltage-dependent subunit beta 3", "protein_names_refseq": "CAB3; Calcium channel subunit beta 3; calcium channel voltage-dependent subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit; voltage-dependent L-type calcium channel subunit beta-3", "tax_id": 10116, "disease": "", "pathway": " (rno:25297); (R-RNO-112308); (R-RNO-422356)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10666413;15170217;22673903;24751537;29742403;34426509;7679112", "class_list": "", "function": "Cavbeta3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic beta-Cells in a Cell-Autonomous Manner., [RefSeq, PubMed]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:10666413, PubMed:15170217, PubMed:24751537, PubMed:29742403, PubMed:7679112). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (PubMed:10666413, PubMed:15170217, PubMed:24751537, PubMed:29742403, PubMed:7679112)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045202 synapse;GO:0016324 apical plasma membrane;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0006816 calcium ion transport;GO:0007268 chemical synaptic transmission;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P54287-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55215-1", "uniprot_id": [ { "id": "CASP2_RAT", "url": "https://www.uniprot.org/uniprot/P55215", "type": "external" } ], "mass": 50728.0, "length": 452, "protein_name": "Caspase-2", "gene_name": "Casp2; Tmem139", "organism": "Rat", "refseq_name": "caspase-2", "refseq_ac": [ { "id": "NP_071967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071967", "type": "external" } ], "gene_names_uniprotkb": "Casp2; Tmem139; Casp2; Ich1", "gene_names_refseq": "Casp2", "protein_names_uniprotkb": "Caspase-2; 3.4.22.55; CASP-2; Protease ICH-1", "protein_names_refseq": "CASP-2; ICH-1 protease; caspase-2; protease ICH-1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); testicular cancer (Disease Ontology:DOID:2998); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:64314); (rno:680244); (R-RNO-168638); (R-RNO-205025); (R-RNO-6803207)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "12067235;16639714;30193318;31533600;32605511;7588240;9427555;9530276", "class_list": "", "function": "Caspase-2 mediates death in a proportion of retinal ganglion cell (RGC) but not photoreceptors at the site of blunt ocular trauma., [RefSeq, PubMed]; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity)., [UniProtKB, UniProtKB]; Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush., [RefSeq, PubMed]; MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35398;O55194;Q9WUI6", "ec_number_list": [ { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" } ], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0008303 caspase complex;GO:1905369 endopeptidase complex", "go_biological_process": "GO:0003407 neural retina development;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P55215-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56403-1", "uniprot_id": [ { "id": "AQP7_RAT", "url": "https://www.uniprot.org/uniprot/P56403", "type": "external" } ], "mass": 28882.0, "length": 269, "protein_name": "Aquaporin-7", "gene_name": "Aqp7", "organism": "Rat", "refseq_name": "aquaporin-7 isoform 1", "refseq_ac": [ { "id": "NP_062030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062030", "type": "external" } ], "gene_names_uniprotkb": "Aqp7", "gene_names_refseq": "AQP-7; Aqp7", "protein_names_uniprotkb": "Aquaporin-7; AQP-7; Aquaglyceroporin-7", "protein_names_refseq": "aquaglyceroporin-7; aquaporin-7 isoform 1", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); morbid obesity (Disease Ontology:DOID:11981); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29171); (R-RNO-432030); (R-RNO-432047)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12192003;22673903;32735865;33506920;36834823;9252401", "class_list": "", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (PubMed:9252401). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity)., [UniProtKB, UniProtKB, PubMed]; Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells., [RefSeq, PubMed]; Differential response of cardiac aquaporins to hyperosmotic stress; salutary role of AQP1 against the induced apoptosis., [RefSeq, PubMed]; Increased Aquaporin-7 Expression Is Associated with Changes in Rat Brown Adipose Tissue Whitening in Obesity: Impact of Cold Exposure and Bariatric Surgery. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3F5", "ec_number_list": [], "go_molecular_function": "GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015265 urea channel activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009410 response to xenobiotic stimulus;GO:0006833 water transport;GO:0015793 glycerol transmembrane transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P56403-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61312-1", "uniprot_id": [ { "id": "ADM2_RAT", "url": "https://www.uniprot.org/uniprot/P61312", "type": "external" } ], "mass": 15572.0, "length": 146, "protein_name": "Protein ADM2", "gene_name": "Adm2", "organism": "Rat", "refseq_name": "protein ADM2 preproprotein", "refseq_ac": [ { "id": "NP_958829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958829", "type": "external" } ], "gene_names_uniprotkb": "Adm2; Am2", "gene_names_refseq": "Adm2; Imd", "protein_names_uniprotkb": "Protein ADM2; IMDL; Intermedin-long; Intermedin", "protein_names_refseq": "intermedin; protein ADM2 preproprotein; protein ADM2", "tax_id": 10116, "disease": "", "pathway": " (rno:399475); (R-RNO-419812)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "14615490;14706825;15652657;16002435;16227344;26479776;30472381;33204068;33300086;35175495;37879153", "class_list": "", "function": "IMD represents a novel estrogen-dependent intermediate lobe-derived prolactin-releasing factor and could play important roles in the regulation of prolactin release during reproduction in females., [RefSeq, PubMed]; IMD, like adrenomedullin, exerts cardio-protective effects against myocardial ischemia/reperfusion injury, [RefSeq, PubMed]; Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway., [RefSeq, PubMed]; Intermedin could be a potential candidate treatment for renal fibrosis., [RefSeq, PubMed]; Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes, [RefSeq, PubMed]; Intermedin protects thapsigargininduced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca(2+)ATPase., [RefSeq, PubMed]; Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes. Activates the cAMP-dependent pathway through interaction with CALCRL-RAMP3 receptor complex., [UniProtKB, PubMed]; Intermedin1-53 Inhibits NLRP3 Inflammasome Activation by Targeting IRE1alpha in Cardiac Fibrosis., [RefSeq, PubMed]; These findings indicate that the physiological roles of rAM2 and rAM are similar and that rAM2 also has a long-lasting vasodilator action on the renal vascular bed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6L5N4", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0006468 protein phosphorylation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61312-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61983-1", "uniprot_id": [ { "id": "1433G_RAT", "url": "https://www.uniprot.org/uniprot/P61983", "type": "external" } ], "mass": 28303.0, "length": 247, "protein_name": "14-3-3 protein gamma", "gene_name": "Ywhag", "organism": "Rat", "refseq_name": "14-3-3 protein gamma", "refseq_ac": [ { "id": "NP_062249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062249", "type": "external" } ], "gene_names_uniprotkb": "Ywhag", "gene_names_refseq": "14-3-3G; Ywhag", "protein_names_uniprotkb": "14-3-3 protein gamma", "protein_names_refseq": "14-3-3 protein gamma-subtype; 14-3-3 protein gamma; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 56 (Disease Ontology:DOID:0080282); intellectual disability (Disease Ontology:DOID:1059); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949)", "pathway": " (rno:56010); (R-RNO-111447); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-75035); (R-RNO-8854518); (R-RNO-9614399); (R-RNO-9929491)", "pathway_count": 14, "publication_count": 9, "publication_id_list": "11427721;18683930;22673903;30093406;30478609;34502162;36427097;38843836;8381897", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1. Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes. Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (By similarity)., [UniProtKB, UniProtKB]; LncRNA SNHG7 Knockdown Aggravates Hepatic Ischemia-Reperfusion Injury and Promotes Apoptosis in Hemorrhagic Shock Pregnant Rats by Modulating miR-34a-5p/YWHAG Axis., [RefSeq, PubMed]; Our findings suggest that preconditioning exercise prior to ischemia induces neuron- and astrocyte-mediated brain ischemic tolerance through increased expression of HIF-1alpha and 14-3-3gamma, which are intrinsic protective factors; the upregulated 14-3-3gamma induced by preconditioning exercise reduces ischemic neuronal cell death through the 14-3-3gamma/p-beta-catenin Ser37/Bax/caspase 3 anti-apoptotic pathway. Erratum:[Brain Struct Funct. 2019 Mar;224(2):739-740. doi: 10.1007/s00429-018-1815-x. PMID: 30560373], [RefSeq, PubMed]; Phosphorylation-independent binding of 14-3-3 has no effect on RGS14/Galphai interactions but, instead, inhibits (directly or indirectly) RGS14 nuclear import and nucleocytoplasmic shuttling Erratum:[J Biol Chem. 2019 Aug 9;294(32):12262. doi: 10.1074/jbc.AAC119.101131. PMID: 31399537], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPM0;O70457;P35214;Q9UDP2;Q9UN99", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61983-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62260-1", "uniprot_id": [ { "id": "1433E_RAT", "url": "https://www.uniprot.org/uniprot/P62260", "type": "external" } ], "mass": 29174.0, "length": 255, "protein_name": "14-3-3 protein epsilon", "gene_name": "Ywhae", "organism": "Rat", "refseq_name": "14-3-3 protein epsilon", "refseq_ac": [ { "id": "NP_113791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113791", "type": "external" } ], "gene_names_uniprotkb": "Ywhae", "gene_names_refseq": "14-3-3e; Ywhae", "protein_names_uniprotkb": "14-3-3 protein epsilon; 14-3-3E; MSF L; Mitochondrial import stimulation factor L subunit", "protein_names_refseq": "14-3-3 epsilon; 14-3-3 protein epsilon; MSF L; mitochondrial import stimulation factor (MSF) L subunit; mitochondrial import stimulation factor L subunit; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide", "tax_id": 10116, "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); left ventricular noncompaction (Disease Ontology:DOID:0060480)", "pathway": " (rno:29753); (R-RNO-111447); (R-RNO-2028269); (R-RNO-205025); (R-RNO-2565942); (R-RNO-3371453); (R-RNO-3371511); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5625740); (R-RNO-5628897); (R-RNO-75035); (R-RNO-8854518); (R-RNO-8876198)", "pathway_count": 17, "publication_count": 11, "publication_id_list": "11427721;18683930;22673903;22827337;24002177;30950109;34502162;38843836;7822263;8024705;8694795", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study of experimental varicocele in rat model demonstrated the pro-apoptotic function of the downregulation of 14-3-3epsilon, which may play an important role in germ cell apoptosis induced by varicocele., [RefSeq, PubMed]; The regulation of 14-3-3 proteins in rotenone-induced neurotoxicity might be associated with its isoform 14-3-3epsilon's involvement in autophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29360;P42655;Q63631", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0007165 signal transduction;GO:0000165 MAPK cascade;GO:0001764 neuron migration;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P62260-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70705-1", "uniprot_id": [ { "id": "ATP7A_RAT", "url": "https://www.uniprot.org/uniprot/P70705", "type": "external" } ], "mass": 162093.0, "length": 1492, "protein_name": "Copper-transporting ATPase 1", "gene_name": "Atp7a", "organism": "Rat", "refseq_name": "copper-transporting ATPase 1", "refseq_ac": [ { "id": "NP_434690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434690", "type": "external" } ], "gene_names_uniprotkb": "Atp7a; Mnk", "gene_names_refseq": "Atp7a; Mnk", "protein_names_uniprotkb": "Copper-transporting ATPase 1; 7.2.2.8; Copper pump 1; Menkes disease-associated protein homolog", "protein_names_refseq": "ATPase, Cu++ transporting, alpha polypeptide; copper pump 1; copper-transporting ATPase 1; menkes disease-associated protein homolog", "tax_id": 10116, "disease": "X-linked distal spinal muscular atrophy 3 (Disease Ontology:DOID:0111196); occipital horn syndrome (Disease Ontology:DOID:0111272); Alzheimer's disease (Disease Ontology:DOID:10652); iron deficiency anemia (Disease Ontology:DOID:11758); spinal muscular atrophy (Disease Ontology:DOID:12377); Menkes disease (Disease Ontology:DOID:1838); cutis laxa (Disease Ontology:DOID:3144); aortic aneurysm (Disease Ontology:DOID:3627); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); osteoarthritis (Disease Ontology:DOID:8398); Wilson disease (Disease Ontology:DOID:893); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (rno:24941); (R-RNO-6803544); (R-RNO-936837)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12488345;15634787;16641100;22673903;29393594;30257103;9562241", "class_list": "", "function": "ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (By similarity). Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway (By similarity). Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions (By similarity). May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3 (By similarity). In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. Cotransfection assay revealed that ATP7A directly bound to NH2-terminal domain of IQGAP1, [RefSeq, PubMed]; This gene encodes a transmembrane protein that functions in copper transport across membranes. The protein localizes to the trans-Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. The protein relocalizes to the plasma membrane under conditions of elevated extracellular copper and functions in the efflux of copper from cells. In human, mutations in this gene result in Menkes disease, X-linked cutis laxa, and occipital horn syndrome. [provided by RefSeq, Nov 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.8", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0031267 small GTPase binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006878 intracellular copper ion homeostasis;GO:0007626 locomotory behavior;GO:0010043 response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70705-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80386-1", "uniprot_id": [ { "id": "AAKB1_RAT", "url": "https://www.uniprot.org/uniprot/P80386", "type": "external" } ], "mass": 30394.0, "length": 270, "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "Prkab1", "organism": "Rat", "refseq_name": "5'-AMP-activated protein kinase subunit beta-1", "refseq_ac": [ { "id": "NP_114182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114182", "type": "external" } ], "gene_names_uniprotkb": "Prkab1", "gene_names_refseq": "Prkab1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit beta-1; 5'-AMP-activated protein kinase 40 kDa subunit; AMPK subunit beta-1; AMPKb", "protein_names_refseq": "5'-AMP-activated protein kinase 40 kDa subunit; 5'-AMP-activated protein kinase subunit beta-1; 5'-AMP-activated protein kinase, beta subunit; 5-AMP-activated protein kinase beta subunit; AMPK beta-1 chain; AMPK subunit beta-1; AMPKb; protein kinase, AMP-activated, beta 1 non-catalytic subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:83803); (R-RNO-1632852); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6804756); (R-RNO-9931269)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "11171104;12764152;16216577;21460634;21481774;22673903;7961907;8621499;8626596;9305909", "class_list": "", "function": "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)., [UniProtKB, UniProtKB, UniProtKB]; Studies determine the three-dimensional reconstruction and subunit organization of the full-length rat AMPK (alpha1beta1gamma1) through single-particle electron, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63048", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006633 fatty acid biosynthetic process;GO:0035878 nail development;GO:0031669 cellular response to nutrient levels;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P80386-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82252-1", "uniprot_id": [ { "id": "BAT1_RAT", "url": "https://www.uniprot.org/uniprot/P82252", "type": "external" } ], "mass": 53658.0, "length": 487, "protein_name": "b(0,+)-type amino acid transporter 1", "gene_name": "Slc7a9", "organism": "Rat", "refseq_name": "B(0,+)-type amino acid transporter 1", "refseq_ac": [ { "id": "NP_446381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446381", "type": "external" } ], "gene_names_uniprotkb": "Slc7a9; Bat1", "gene_names_refseq": "Slc7a9", "protein_names_uniprotkb": "b(0,+)-type amino acid transporter 1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9; b(0,+)AT", "protein_names_refseq": "B(0,+)-type amino acid transporter 1; b(0,+)AT; glycoprotein-associated amino acid transporter b0,+AT1; solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9; solute carrier family 7 (cationic amino acid transporter, y+ system), member 9; solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9", "tax_id": 10116, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (rno:116726); (R-RNO-210991); (R-RNO-352230)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10506124;16358225;22673903", "class_list": "", "function": "Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10506124). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM04", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0042605 peptide antigen binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0015804 neutral amino acid transport;GO:0015811 L-cystine transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82252-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32Q06-1", "uniprot_id": [ { "id": "AP1M1_RAT", "url": "https://www.uniprot.org/uniprot/Q32Q06", "type": "external" } ], "mass": 48557.0, "length": 423, "protein_name": "AP-1 complex subunit mu-1", "gene_name": "Ap1m1", "organism": "Rat", "refseq_name": "AP-1 complex subunit mu-1", "refseq_ac": [ { "id": "NP_001037704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037704", "type": "external" } ], "gene_names_uniprotkb": "Ap1m1", "gene_names_refseq": "Ap1m1", "protein_names_uniprotkb": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; Adaptor protein complex AP-1 subunit mu-1; Adaptor-related protein complex 1 subunit mu-1; Clathrin assembly protein complex 1 mu-1 medium chain 1; Golgi adaptor HA1/AP1 adaptin mu-1 subunit; Mu-adaptin 1; Mu1A-adaptin", "protein_names_refseq": "AP-1 complex subunit mu-1; AP-mu chain family member mu1A; adapter-related protein complex 1 subunit mu-1; adaptor protein complex AP-1 mu-1 subunit; adaptor protein complex AP-1 subunit mu-1; adaptor-related protein complex 1, mu 1 subunit; adaptor-related protein complex AP-1, mu subunit 1; clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1 mu-1 medium chain 1; golgi adaptor HA1/AP1 adaptin mu-1 subunit; mu-adaptin 1; mu1A-adaptin", "tax_id": 10116, "disease": "", "pathway": " (rno:306332); (R-RNO-2132295); (R-RNO-432720); (R-RNO-432722); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17604280;22673903;22958822;29393594", "class_list": "", "function": "Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The primary recognition event that underlies somatodendritic sorting contributes to the evolving view of AP-1 as a global regulator of cell polarity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0045202 synapse;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0030665 clathrin-coated vesicle membrane;GO:0030131 clathrin adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032438 melanosome organization;GO:0035646 endosome to melanosome transport;GO:0006896 Golgi to vacuole transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q32Q06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLH6-1", "uniprot_id": [ { "id": "CE162_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLH6", "type": "external" } ], "mass": 161001.0, "length": 1403, "protein_name": "Centrosomal protein of 162 kDa", "gene_name": "Cep162", "organism": "Rat", "refseq_name": "centrosomal protein of 162 kDa", "refseq_ac": [ { "id": "NP_001263989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263989", "type": "external" } ], "gene_names_uniprotkb": "Cep162; Qn1", "gene_names_refseq": "Cep162; Qn1; RGD1307365", "protein_names_uniprotkb": "Centrosomal protein of 162 kDa; Cep162; Protein QN1 homolog", "protein_names_refseq": "centrosomal protein of 162 kDa; protein QN1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:300880); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16302001;22673903", "class_list": "", "function": "Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005814 centriole;GO:0034451 centriolar satellite", "go_biological_process": "GO:0060271 cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLH6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR76-1", "uniprot_id": [ { "id": "ACL7B_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR76", "type": "external" } ], "mass": 45492.0, "length": 417, "protein_name": "Actin-like protein 7B", "gene_name": "Actl7b", "organism": "Rat", "refseq_name": "actin-like protein 7B", "refseq_ac": [ { "id": "NP_001020588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020588", "type": "external" } ], "gene_names_uniprotkb": "Actl7b", "gene_names_refseq": "Actl7b", "protein_names_uniprotkb": "Actin-like protein 7B", "protein_names_refseq": "actin-like protein 7B", "tax_id": 10116, "disease": "", "pathway": " (rno:313183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QR76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B5-1", "uniprot_id": [ { "id": "CC116_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B5", "type": "external" } ], "mass": 59680.0, "length": 540, "protein_name": "Coiled-coil domain-containing protein 116", "gene_name": "Ccdc116", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 116 isoform 2", "refseq_ac": [ { "id": "NP_001019911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019911", "type": "external" } ], "gene_names_uniprotkb": "Ccdc116", "gene_names_refseq": "Ccdc116; Sdf2l1", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 116", "protein_names_refseq": "coiled-coil domain-containing protein 116 isoform 2; coiled-coil domain-containing protein 116; stromal cell-derived factor 2-like 1", "tax_id": 10116, "disease": "lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:287936)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8B5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI58-1", "uniprot_id": [ { "id": "CALI_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI58", "type": "external" } ], "mass": 66765.0, "length": 588, "protein_name": "Calicin", "gene_name": "Ccin", "organism": "Rat", "refseq_name": "calicin", "refseq_ac": [ { "id": "NP_001005904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005904", "type": "external" } ], "gene_names_uniprotkb": "Ccin", "gene_names_refseq": "Ccin", "protein_names_uniprotkb": "Calicin", "protein_names_refseq": "calicin", "tax_id": 10116, "disease": "spermatogenic failure 91 (Disease Ontology:DOID:0070590)", "pathway": " (rno:298392)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Required for both nuclear and acrosomal shaping during spermiogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0033150 cytoskeletal calyx;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0033011 perinuclear theca;GO:0120238 sperm glycocalyx", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI58-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIJ6-1", "uniprot_id": [ { "id": "BABA1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIJ6", "type": "external" } ], "mass": 36878.0, "length": 334, "protein_name": "BRISC and BRCA1-A complex member 1", "gene_name": "Babam1", "organism": "Rat", "refseq_name": "BRISC and BRCA1-A complex member 1", "refseq_ac": [ { "id": "NP_001006965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006965", "type": "external" } ], "gene_names_uniprotkb": "Babam1; Merit40; Nba1", "gene_names_refseq": "Babam1; Merit40", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex", "protein_names_refseq": "BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; mediator of RAP80 interactions and targeting subunit of 40 kDa; new component of the BRCA1-A complex", "tax_id": 10116, "disease": "", "pathway": " (rno:290631); (R-RNO-5689901); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex", "go_biological_process": "GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FX6-1", "uniprot_id": [ { "id": "CABS1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FX6", "type": "external" } ], "mass": 42256.0, "length": 390, "protein_name": "Calcium-binding and spermatid-specific protein 1", "gene_name": "Cabs1", "organism": "Rat", "refseq_name": "calcium-binding and spermatid-specific protein 1", "refseq_ac": [ { "id": "NP_071599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071599", "type": "external" } ], "gene_names_uniprotkb": "Cabs1; Clph; Rsd6", "gene_names_refseq": "Cabs1; Clph; Rsd6", "protein_names_uniprotkb": "Calcium-binding and spermatid-specific protein 1; Casein-like phosphoprotein; Protein RSD-6", "protein_names_refseq": "RSD-6; calcium-binding and spermatid-specific protein 1; calcium-binding protein, spermatid-specific 1; casein-like phosphoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:64029)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19271754;22673903", "class_list": "", "function": "Calcium-binding protein (PubMed:19271754). Essential for maintaining the structural integrity of the sperm flagella (By similarity)., [UniProtKB, PubMed, UniProtKB]; Identified CLPH (for Casein-Like PHosphoprotein), a new testis-specific protein expressed exclusively in postmeiotic germ cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI16", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031514 motile cilium;GO:0001669 acrosomal vesicle;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68FX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXP4-1", "uniprot_id": [ { "id": "CB081_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXP4", "type": "external" } ], "mass": 65892.0, "length": 597, "protein_name": "Uncharacterized protein C2orf81 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C2orf81 homolog", "refseq_ac": [ { "id": "NP_001019501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019501", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C4h2orf81", "protein_names_uniprotkb": "Uncharacterized protein C2orf81 homolog", "protein_names_refseq": "hypothetical gene supported by BC079424; uncharacterized protein C2orf81 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500227)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT4-1", "uniprot_id": [ { "id": "CC172_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT4", "type": "external" } ], "mass": 31075.0, "length": 263, "protein_name": "Coiled-coil domain-containing protein 172", "gene_name": "Ccdc172", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 172", "refseq_ac": [ { "id": "NP_001014191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014191", "type": "external" } ], "gene_names_uniprotkb": "Ccdc172; Tekt2bp1", "gene_names_refseq": "Ccdc172", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 172; TEKT2-binding protein 1", "protein_names_refseq": "TEKT2-binding protein 1; UPF0628 protein C10orf96 homolog; coiled-coil domain-containing protein 172", "tax_id": 10116, "disease": "", "pathway": " (rno:361776)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24394471", "class_list": "", "function": "TEKT2BP1 was predominantly expressed in rat testis and that its expression was increased after 3 weeks of postnatal development; a flagella component predominantly associated with mitochondria in the middle piece of flagella., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097225 sperm midpiece", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZD5-1", "uniprot_id": [ { "id": "AMGO3_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZD5", "type": "external" } ], "mass": 55565.0, "length": 508, "protein_name": "Amphoterin-induced protein 3", "gene_name": "Amigo3", "organism": "Rat", "refseq_name": "amphoterin-induced protein 3 precursor", "refseq_ac": [ { "id": "NP_835280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835280", "type": "external" } ], "gene_names_uniprotkb": "Amigo3; Ali3", "gene_names_refseq": "Amigo3", "protein_names_uniprotkb": "Amphoterin-induced protein 3; AMIGO-3; Alivin-3", "protein_names_refseq": "AMIGO-3; alivin-3; amphoterin induced gene and ORF 3; amphoterin-induced protein 3 precursor; amphoterin-induced protein 3; transmembrane protein AMIGO3", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (rno:316003)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12629050", "class_list": "", "function": "May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0010977 negative regulation of neuron projection development;GO:0007420 brain development;GO:0051965 positive regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80ZD5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZD7-1", "uniprot_id": [ { "id": "AMGO1_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZD7", "type": "external" } ], "mass": 55283.0, "length": 493, "protein_name": "Amphoterin-induced protein 1", "gene_name": "Amigo1", "organism": "Rat", "refseq_name": "amphoterin-induced protein 1 precursor", "refseq_ac": [ { "id": "NP_996764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996764", "type": "external" } ], "gene_names_uniprotkb": "Amigo1; Ali2; Amigo", "gene_names_refseq": "Amigo1; Amigo", "protein_names_uniprotkb": "Amphoterin-induced protein 1; AMIGO-1; Alivin-2", "protein_names_refseq": "AMIGO-1; alivin-2; amphoretin-induced gene and ORF; amphoterin-induced protein 1 precursor; amphoterin-induced protein 1; transmembrane protein AMIGO", "tax_id": 10116, "disease": "", "pathway": " (rno:295365)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12629050;21938721;22056818;22673903", "class_list": "", "function": "AMIGO is a function-modulating auxiliary subunit for Kv2.1. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that AMIGO is a glycosylated protein widely expressed in the central nervous system (CNS), and can be found in neurons, astrocytes as well as oligodendrocytes., [RefSeq, PubMed]; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (PubMed:12629050). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0010976 positive regulation of neuron projection development;GO:0042552 myelination;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q80ZD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4I6-1", "uniprot_id": [ { "id": "CBY1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4I6", "type": "external" } ], "mass": 14549.0, "length": 127, "protein_name": "Protein chibby homolog 1", "gene_name": "Cby1", "organism": "Rat", "refseq_name": "protein chibby homolog 1", "refseq_ac": [ { "id": "NP_663709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663709", "type": "external" } ], "gene_names_uniprotkb": "Cby1; Cby; Pgea1", "gene_names_refseq": "Cby1; Pgea1", "protein_names_uniprotkb": "Protein chibby homolog 1; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1", "protein_names_refseq": "PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; PKD2 interactor, golgi and endoplasmic reticulum associated 1; chibby family member 1, beta catenin antagonist; chibby homolog 1; cytosolic leucine-rich protein; protein chibby homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:246768); (R-RNO-3769402)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0016607 nuclear speck;GO:0036126 sperm flagellum;GO:0005814 centriole", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0060271 cilium assembly;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHX0-1", "uniprot_id": [ { "id": "CCG3_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHX0", "type": "external" } ], "mass": 35516.0, "length": 315, "protein_name": "Voltage-dependent calcium channel gamma-3 subunit", "gene_name": "Cacng3", "organism": "Rat", "refseq_name": "voltage-dependent calcium channel gamma-3 subunit", "refseq_ac": [ { "id": "NP_542422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542422", "type": "external" } ], "gene_names_uniprotkb": "Cacng3", "gene_names_refseq": "Cacng3", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3", "protein_names_refseq": "TARP gamma-3; calcium channel, voltage-dependent, gamma subunit 3; neuronal voltage-gated calcium channel gamma-3 subunit; transmembrane AMPAR regulatory protein gamma-3; voltage-dependent calcium channel gamma-3 subunit", "tax_id": 10116, "disease": "childhood absence epilepsy (Disease Ontology:DOID:1825); macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (rno:140724); (R-RNO-399719); (R-RNO-5682910)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11738816;17880894;19234459;19265014;22673903", "class_list": "", "function": "Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0005245 voltage-gated calcium channel activity;GO:0035255 ionotropic glutamate receptor binding;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0032281 AMPA glutamate receptor complex;GO:0036477 somatodendritic compartment;GO:0060076 excitatory synapse", "go_biological_process": "GO:0006605 protein targeting;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:2000969 positive regulation of AMPA receptor activity;GO:0019226 transmission of nerve impulse;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y80-1", "uniprot_id": [ { "id": "3BP5_RAT", "url": "https://www.uniprot.org/uniprot/Q91Y80", "type": "external" } ], "mass": 50829.0, "length": 457, "protein_name": "SH3 domain-binding protein 5", "gene_name": "Sh3bp5", "organism": "Rat", "refseq_name": "SH3 domain-binding protein 5", "refseq_ac": [ { "id": "NP_446463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446463", "type": "external" } ], "gene_names_uniprotkb": "Sh3bp5; Sab; Vesp18", "gene_names_refseq": "SH3BP-5; Sab; Sh3bp5; Vesp18", "protein_names_uniprotkb": "SH3 domain-binding protein 5; SH3BP-5; Vascular endothelial cell-specific protein 18", "protein_names_refseq": "SH3 domain-binding protein 5; SH3-domain binding protein 5 (BTK-associated); vascular endothelial cell-specific protein 18", "tax_id": 10116, "disease": "", "pathway": " (rno:117186)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15158451;22673903", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death., [UniProtKB, UniProtKB]; Mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0004860 protein kinase inhibitor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030659 cytoplasmic vesicle membrane;GO:0016604 nuclear body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006469 negative regulation of protein kinase activity;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91Y80-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES19-1", "uniprot_id": [ { "id": "ATF4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES19", "type": "external" } ], "mass": 38152.0, "length": 347, "protein_name": "Cyclic AMP-dependent transcription factor ATF-4", "gene_name": "Atf4", "organism": "Rat", "refseq_name": "cyclic AMP-dependent transcription factor ATF-4", "refseq_ac": [ { "id": "NP_077379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077379", "type": "external" } ], "gene_names_uniprotkb": "Atf4", "gene_names_refseq": "Atf4", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-4; Activating transcription factor 4; cAMP-dependent transcription factor ATF-4; rATF-4", "protein_names_refseq": "activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4; rATF-4", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); borna disease (Disease Ontology:DOID:5154); pulmonary venoocclusive disease (Disease Ontology:DOID:5453)", "pathway": " (rno:79255)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10924501;35403324;35531910;35574856;36928813;38879481;8506317", "class_list": "", "function": "ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress., [RefSeq, PubMed]; Activating Transcription Factor 4-mediated Mitochondrial Unfolded Protein Response Alleviates Hippocampal Neuronal Damage in an In Vitro Model of Epileptiform Discharges., [RefSeq, PubMed]; HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model. Publication Status: Online-Only, [RefSeq, PubMed]; Possible effects of fibroblast growth factor 21 on vascular calcification via suppressing activating transcription factor 4 mediated apoptosis and osteogenic transformation in rats., [RefSeq, PubMed]; Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury., [RefSeq, PubMed]; Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (By similarity). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity). Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, ATF4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced ATF4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity). Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity). Activates the transcription of NLRP1, possibly in concert with other factors in response to ER stress. Activates the transcription of asparagine synthetase (ASNS) in response to amino acid deprivation or ER stress. However, when associated with DDIT3/CHOP, the transcriptional activation of the ASNS gene is inhibited in response to amino acid deprivation (By similarity). Together with DDIT3/CHOP, mediates programmed cell death by promoting the expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the terminal unfolded protein response (terminal UPR), a cellular response that elicits programmed cell death when ER stress is prolonged and unresolved (By similarity). Activates the expression of COX7A2L/SCAF1 downstream of the EIF2AK3/PERK-mediated unfolded protein response, thereby promoting formation of respiratory chain supercomplexes and increasing mitochondrial oxidative phosphorylation (By similarity). Together with DDIT3/CHOP, activates the transcription of the IRS-regulator TRIB3 and promotes ER stress-induced neuronal cell death by regulating the expression of BBC3/PUMA in response to ER stress. May cooperate with the UPR transcriptional regulator QRICH1 to regulate ER protein homeostasis which is critical for cell viability in response to ER stress (By similarity). In the absence of stress, ATF4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity). Acts as a regulator of osteoblast differentiation in response to phosphorylation by RPS6KA3/RSK2: phosphorylation in osteoblasts enhances transactivation activity and promotes expression of osteoblast-specific genes and post-transcriptionally regulates the synthesis of Type I collagen, the main constituent of the bone matrix (By similarity). Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor: acts as a regulator of synaptic plasticity by repressing transcription, thereby inhibiting induction and maintenance of long-term memory (By similarity). Regulates synaptic functions via interaction with DISC1 in neurons, which inhibits ATF4 transcription factor activity by disrupting ATF4 dimerization and DNA-binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0070982 L-asparagine metabolic process;GO:0035162 embryonic hemopoiesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ES19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHX4-1", "uniprot_id": [ { "id": "CASP8_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHX4", "type": "external" } ], "mass": 55339.0, "length": 482, "protein_name": "Caspase-8", "gene_name": "Casp8", "organism": "Rat", "refseq_name": "caspase-8", "refseq_ac": [ { "id": "NP_071613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071613", "type": "external" } ], "gene_names_uniprotkb": "Casp8", "gene_names_refseq": "CASP-8; Casp8", "protein_names_uniprotkb": "Caspase-8; 3.4.22.61; CASP-8", "protein_names_refseq": "caspase-8", "tax_id": 10116, "disease": "pre-malignant neoplasm (Disease Ontology:DOID:0060071); traumatic brain injury (Disease Ontology:DOID:0081292); autoimmune lymphoproliferative syndrome type 2B (Disease Ontology:DOID:0110116); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); autoimmune disease (Disease Ontology:DOID:417); esophagus adenocarcinoma (Disease Ontology:DOID:4914); retinal detachment (Disease Ontology:DOID:5327); kidney disease (Disease Ontology:DOID:557); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:64044); (R-RNO-111465); (R-RNO-140534); (R-RNO-168638); (R-RNO-2562578); (R-RNO-264870); (R-RNO-3371378); (R-RNO-5218900); (R-RNO-5357905); (R-RNO-5660668); (R-RNO-5675482); (R-RNO-69416); (R-RNO-75108); (R-RNO-75153); (R-RNO-75157); (R-RNO-75158); (R-RNO-9758274)", "pathway_count": 17, "publication_count": 8, "publication_id_list": "10197541;15383280;22673903;33434617;33456665;33847039;34314869;36567583", "class_list": "", "function": "Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant rat models., [RefSeq, PubMed]; Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation. Publication Status: Online-Only, [RefSeq, PubMed]; Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction., [RefSeq, PubMed]; Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma., [RefSeq, PubMed]; Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:10197541). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (By similarity). Binding to the adapter molecule FADD recruits it to either receptor FAS/CD95 or TNFRSF1A (PubMed:10197541). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (By similarity). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (By similarity). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (By similarity). Also cleaves and activates BID, thereby promoting cytochrome C release from mitochrondria (By similarity). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-325', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (By similarity). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (By similarity). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (By similarity). Cleaves PARP1 and PARP2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; [Role of caspase-8 in stem cell transplantation alleviates rat cerebral cortex apoptosis after cardiopulmonary resuscitation]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.22.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.36", "type": "external" }, { "id": "3.4.22.55", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.55", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0007507 heart development;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHX4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKL8-1", "uniprot_id": [ { "id": "ADNP_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKL8", "type": "external" } ], "mass": 123626.0, "length": 1103, "protein_name": "Activity-dependent neuroprotector homeobox protein", "gene_name": "Adnp", "organism": "Rat", "refseq_name": "activity-dependent neuroprotector homeobox protein", "refseq_ac": [ { "id": "NP_001416414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416414", "type": "external" } ], "gene_names_uniprotkb": "Adnp", "gene_names_refseq": "Adnp", "protein_names_uniprotkb": "Activity-dependent neuroprotector homeobox protein; Activity-dependent neuroprotective protein", "protein_names_refseq": "NAP peptide; activity-dependent neuroprotective protein; activity-dependent neuroprotector homeobox protein", "tax_id": 10116, "disease": "Helsmoortel-Van Der Aa Syndrome (Disease Ontology:DOID:0070058); ischemia (Disease Ontology:DOID:326); brain infarction (Disease Ontology:DOID:3454)", "pathway": " (rno:64622); (R-RNO-9940465)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22454142;22673903;23272107;25178163;27003787;38673966", "class_list": "", "function": "An endogenous PACAP-mediated ADNP signaling system increases malignant peripheral nerve sheath tumor cell resistance to hydrogen-peroxide-induced death upon serum starvation., [RefSeq, PubMed]; May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation., [UniProtKB, UniProtKB]; Moderate Physical Activity Increases the Expression of ADNP in Rat Brain. Publication Status: Online-Only, [RefSeq, PubMed]; NAP is an ADNP derived peptide that modulates the tubulin pool in mice and rats, [RefSeq, PubMed]; The newly identified shared microtubule target of NAP/ADNP is directly implicated in synaptic plasticity, explaining the breadth and efficiency of neuroprotective/neurotrophic capacities, [RefSeq, PubMed]; These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease, [RefSeq, PubMed]; This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. [provided by RefSeq, Nov 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V7G3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKL8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLB5-1", "uniprot_id": [ { "id": "ACH10_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLB5", "type": "external" } ], "mass": 49820.0, "length": 447, "protein_name": "Neuronal acetylcholine receptor subunit alpha-10", "gene_name": "Chrna10", "organism": "Rat", "refseq_name": "neuronal acetylcholine receptor subunit alpha-10 precursor", "refseq_ac": [ { "id": "NP_072161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072161", "type": "external" } ], "gene_names_uniprotkb": "Chrna10", "gene_names_refseq": "Chrna10", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-10; NACHR alpha-10; Nicotinic acetylcholine receptor subunit alpha-10", "protein_names_refseq": "NACHR alpha-10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; neuronal acetylcholine receptor subunit alpha-10 precursor; neuronal acetylcholine receptor subunit alpha-10; neuronal nicotinic acetylcholine receptor subunit; nicotinic acetylcholine receptor subunit alpha-10", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (rno:64574)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "11248107;12117536;12401316;12414097;14742688;15356192;16306403;22371598;22774872;25740413;26395518;28069778;39120784", "class_list": "", "function": "A two order of magnitude species difference in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR., [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11248107, PubMed:12117536, PubMed:14742688, PubMed:16306403). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:14742688, PubMed:16306403). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11248107, PubMed:12117536). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (PubMed:11248107). May also regulate keratinocyte adhesion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Developmental mRNA expression of the alpha10 nicotinic acetylcholine receptor subunit in the rat cochlea, [RefSeq, PubMed]; Dorsal root ganglion neurons coexpress alpha 10 nicotinic acetylcholine receptor subunit with the alpha 9 subunit, thereby providing the first example of neuronal expression of this receptor subunit pair., [RefSeq, PubMed]; Key role of the TM2-TM3 loop in calcium potentiation of the alpha9alpha10 nicotinic acetylcholine receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Original cloning and developmental analysis of alpha10 expression GeneRIF: Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor., [RefSeq, PubMed]; Permeability of the recombinant alpha 9 alpha 10 nicotinic acetylcholine receptor to Ca(2+), Ba(2+) and Mg(2+) and its modulation by these divalent cations, [RefSeq, PubMed]; The contribution of subunit interface domains to alpha9alpha10 receptors by a combination of electrophysiological and radioligand binding studies, is reported. Erratum:[Mol Pharmacol. 2017 May;91(5):437. doi: 10.1124/mol.111.107482err. PMID: 28325810], [RefSeq, PubMed]; The properties of rat and chicken recombinant and native alpha9alpha10 receptors, were compared., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0022850 serotonin-gated monoatomic cation channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0030424 axon;GO:0043204 perikaryon;GO:0045202 synapse", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007271 synaptic transmission, cholinergic;GO:0042391 regulation of membrane potential;GO:0042472 inner ear morphogenesis;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JLB5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JMB5-1", "uniprot_id": [ { "id": "ADRM1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JMB5", "type": "external" } ], "mass": 42102.0, "length": 407, "protein_name": "Proteasomal ubiquitin receptor ADRM1", "gene_name": "Adrm1", "organism": "Rat", "refseq_name": "proteasomal ubiquitin receptor ADRM1", "refseq_ac": [ { "id": "NP_113896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113896", "type": "external" } ], "gene_names_uniprotkb": "Adrm1; Gp110", "gene_names_refseq": "Adrm1; Gp110", "protein_names_uniprotkb": "Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; ARM-1; Adhesion-regulating molecule 1; Gp110; Rpn13 homolog", "protein_names_refseq": "110 kDa cell membrane glycoprotein; ARM-1; adhesion regulating molecule 1; cell membrane glycoprotein, 110000M(r) (surface antigen); glycoprotein 110; proteasomal ubiquitin receptor ADRM1; rpn13 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:65138); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 56, "publication_count": 2, "publication_id_list": "11018266;22673903", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P795", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0033081 regulation of T cell differentiation in thymus;GO:0060399 positive regulation of growth hormone receptor signaling pathway;GO:0060612 adipose tissue development;GO:0007286 spermatid development;GO:0048538 thymus development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JMB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0E0-1", "uniprot_id": [ { "id": "CEGT_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0E0", "type": "external" } ], "mass": 44823.0, "length": 394, "protein_name": "Ceramide glucosyltransferase", "gene_name": "Ugcg", "organism": "Rat", "refseq_name": "ceramide glucosyltransferase", "refseq_ac": [ { "id": "NP_113983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113983", "type": "external" } ], "gene_names_uniprotkb": "Ugcg", "gene_names_refseq": "Ugcg", "protein_names_uniprotkb": "Ceramide glucosyltransferase; 2.4.1.80; GCS; GLCT-1; Glucosylceramide synthase; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase", "protein_names_refseq": "GCS; GLCT-1; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP-glucose:ceramide glycosyltransferase; ceramide glucosyltransferase; glucosylceramide synthase; glycosylceramide synthase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:83626); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10393098;11337504;1532799;9867864", "class_list": "glycogene;glycosyltransferase", "function": "Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) (PubMed:10393098, PubMed:1532799). Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures (By similarity). Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction (By similarity). They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions (By similarity). They are required for instance in the proper development and functioning of the nervous system. As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway (By similarity). They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope (By similarity). The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). Catalyzes the synthesis of xylosylceramide/XylCer (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) using UDP-Xyl as xylose donor (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 29, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55149", "ec_number_list": [ { "id": "2.4.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.80", "type": "external" } ], "go_molecular_function": "GO:0008120 ceramide glucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0061436 establishment of skin barrier;GO:0030216 keratinocyte differentiation;GO:0006497 protein lipidation;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R0E0-1", "record_type": "protein", "filter_code": "0000000.1100111.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1T4-1", "uniprot_id": [ { "id": "CNKR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1T4", "type": "external" } ], "mass": 117390.0, "length": 1032, "protein_name": "Connector enhancer of kinase suppressor of ras 2", "gene_name": "Cnksr2", "organism": "Rat", "refseq_name": "connector enhancer of kinase suppressor of ras 2 isoform 1", "refseq_ac": [ { "id": "NP_001106837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106837", "type": "external" } ], "gene_names_uniprotkb": "Cnksr2", "gene_names_refseq": "Cnksr2", "protein_names_uniprotkb": "Connector enhancer of kinase suppressor of ras 2; CNK homolog protein 2; CNK2; Connector enhancer of KSR 2; Maguin; Membrane-associated guanylate kinase-interacting protein", "protein_names_refseq": "CNK homolog protein 2; CNK2; connector enhancer of KSR 2; connector enhancer of kinase suppressor of ras 2 isoform 1; maguin-1; maguin-2; membrane-associated guanylate kinase-interacting protein", "tax_id": 10116, "disease": "syndromic X-linked mental retardation Hough type (Disease Ontology:DOID:0080242)", "pathway": " (rno:59322); (R-RNO-5674135)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10207009;12028359;22673903;32235845", "class_list": "", "function": "Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK. Publication Status: Online-Only, [RefSeq, PubMed]; MAGUIN-1 and -2 are recruited to synapses by the pleckstrin homology domain and that MAGUIN-1 subsequently interacts with PSD-95 at synapses., [RefSeq, PubMed]; May function as an adapter protein or regulator of Ras signaling pathways, in synaptic junctions., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R093", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0009966 regulation of signal transduction;GO:0007167 enzyme-linked receptor protein signaling pathway;GO:0099173 postsynapse organization;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z1T4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35570-1", "uniprot_id": [ { "id": "IRS1_RAT", "url": "https://www.uniprot.org/uniprot/P35570", "type": "external" } ], "mass": 131178.0, "length": 1235, "protein_name": "Insulin receptor substrate 1", "gene_name": "Irs1", "organism": "Rat", "refseq_name": "insulin receptor substrate 1", "refseq_ac": [ { "id": "NP_037101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037101", "type": "external" } ], "gene_names_uniprotkb": "Irs1; Irs-1", "gene_names_refseq": "IRS1IRM; Irs1", "protein_names_uniprotkb": "Insulin receptor substrate 1; IRS-1; pp185", "protein_names_refseq": "IRS-1; insulin receptor substrate 1; pp185", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); osteoporosis (Disease Ontology:DOID:11476); uterine fibroid (Disease Ontology:DOID:13223); coronary artery disease (Disease Ontology:DOID:3393); glucose metabolism disease (Disease Ontology:DOID:4194); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25467); (R-RNO-109704); (R-RNO-112399); (R-RNO-112412); (R-RNO-1257604); (R-RNO-1266695); (R-RNO-198203); (R-RNO-201556); (R-RNO-2428928); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-74713); (R-RNO-74749); (R-RNO-9842663)", "pathway_count": 14, "publication_count": 118, "publication_id_list": "11018022;11160134;11287630;11416002;11606564;11739394;12006582;12006586;12399410;12510059;1380456;14550547;14556646;15198936;15240096;15297437;15302844;15485932;15787606;15849359;16000877;16150913;16244361;1648180;16684854;16896943;16934905;16940436;17003331;17288791;17403295;17438698;17570255;17728140;17823255;17951543;18354292;19001546;19121314;19171190;19386987;19646964;19671924;19686764;19703555;19728324;19781177;19819682;2022647;20307567;20459025;20596724;20946888;20967757;21088934;21282367;21320568;21514684;21543456;21926342;21940847;22314193;22362362;22673903;23328071;23715867;23840461;23840732;24187137;24257416;24314869;24366086;24389792;24460535;24704288;24788483;24797633;25352752;25437926;25586176;25883115;25978724;26084330;26433940;26455923;26965244;27168847;27185631;27250532;27517611;27739494;28651236;29036927;29043342;29154269;29370351;29551354;29882093;30225267;30550886;31766382;32444657;32844579;33336396;33497738;33824679;33859259;34069933;34942345;35347917;36207218;36346578;37248076;7504175;7651388;8349691;8491186;8631859", "class_list": "", "function": "Activation of Wnt/beta-catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS-1., [RefSeq, PubMed]; Changes of LRP6/beta-catenin pathway in adipose tissue of rats with intrauterine growth restriction with catch-up growth., [RefSeq, PubMed]; IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis., [RefSeq, PubMed]; Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis., [RefSeq, PubMed]; Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:12399410). Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2 (PubMed:1380456). Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signaling cascade (PubMed:8491186). Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation (By similarity). Acts a positive regulator of the Wnt/beta-catenin signaling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; [Effect of miR-96-5p targeting IRS1 on apoptosis of PC12 cells induced by aluminum maltol]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 0, "mined_o_glycosites": 4, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 47, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0030335 positive regulation of cell migration;GO:0032000 positive regulation of fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 12.4, "record_id": "P35570-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100010000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62844-1", "uniprot_id": [ { "id": "FYN_RAT", "url": "https://www.uniprot.org/uniprot/Q62844", "type": "external" } ], "mass": 60702.0, "length": 537, "protein_name": "Tyrosine-protein kinase Fyn", "gene_name": "Fyn", "organism": "Rat", "refseq_name": "tyrosine-protein kinase Fyn", "refseq_ac": [ { "id": "NP_036887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036887", "type": "external" } ], "gene_names_uniprotkb": "Fyn", "gene_names_refseq": "Fyn", "protein_names_uniprotkb": "Tyrosine-protein kinase Fyn; 2.7.10.2; Proto-oncogene c-Fyn; p59-Fyn", "protein_names_refseq": "FYN oncogene related to SRC, FGR, YES; p59-Fyn; proto-oncogene c-Fyn; proto-oncogene tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574); asthma (Disease Ontology:DOID:2841); Goldenhar syndrome (Disease Ontology:DOID:2907); skin squamous cell carcinoma (Disease Ontology:DOID:3151); temporal lobe epilepsy (Disease Ontology:DOID:3328); skin disease (Disease Ontology:DOID:37); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25150); (R-RNO-114604); (R-RNO-1227986); (R-RNO-1257604); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-2029481); (R-RNO-210990); (R-RNO-2424491); (R-RNO-373753); (R-RNO-375165); (R-RNO-389356); (R-RNO-389357); (R-RNO-389359); (R-RNO-389513); (R-RNO-3928662); (R-RNO-3928663); (R-RNO-3928664); (R-RNO-3928665); (R-RNO-399954); (R-RNO-399955); (R-RNO-399956); (R-RNO-418885); (R-RNO-4420097); (R-RNO-5621480); (R-RNO-5621575); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-75892); (R-RNO-8866376); (R-RNO-9032759); (R-RNO-912631); (R-RNO-9766229)", "pathway_count": 33, "publication_count": 8, "publication_id_list": "10366594;15715669;2062320;22673903;31852295;32145272;32929078;33409551", "class_list": "", "function": "Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Fyn gene silencing reduced the apoptosis of OLs through inhibiting the phosphorylation of ERK1/2 in epileptic model, [RefSeq, PubMed]; Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model., [RefSeq, PubMed]; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance (PubMed:10366594). Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain (By similarity). Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions (By similarity). Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin) (By similarity). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT (By similarity). Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage (By similarity). Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6 (By similarity). Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein (By similarity). Involved in reelin signaling by mediating phosphorylation of DAB1 following reelin (RELN)-binding to its receptor (By similarity). Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation (By similarity). Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation (By similarity). Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1 and PDCD1 (By similarity). Phosphorylation of PAG1 promotes interaction between PAG1 and CSK and recruitment of CSK to lipid rafts (By similarity). Phosphorylation of PDCD1 leads to the recruitment of PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules (By similarity). CSK maintains LCK and FYN in an inactive form (By similarity). Promotes CD28-induced phosphorylation of VAV1 (By similarity). In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). Can also promote CD244-mediated NK cell activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005768 endosome;GO:0005829 cytosol", "go_biological_process": "GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q62844-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02693-1", "uniprot_id": [ { "id": "FABPI_RAT", "url": "https://www.uniprot.org/uniprot/P02693", "type": "external" } ], "mass": 15124.0, "length": 132, "protein_name": "Fatty acid-binding protein, intestinal", "gene_name": "Fabp2", "organism": "Rat", "refseq_name": "fatty acid-binding protein, intestinal", "refseq_ac": [ { "id": "NP_037200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037200", "type": "external" } ], "gene_names_uniprotkb": "Fabp2; Fabpi", "gene_names_refseq": "FABP; Fabp2", "protein_names_uniprotkb": "Fatty acid-binding protein, intestinal; Fatty acid-binding protein 2; I-FABP; Intestinal-type fatty acid-binding protein", "protein_names_refseq": "FABPI; I-FABP; fatty acid binding protein 1; fatty acid binding protein 2, intestinal; fatty acid-binding protein, intestinal; intestinal fatty acid binding protein; intestinal-type fatty acid-binding protein", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); adrenal cortical adenoma (Disease Ontology:DOID:0050891); stroke (Disease Ontology:DOID:0051061); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); glucocorticoid-remediable aldosteronism (Disease Ontology:DOID:14080); renal tubular acidosis (Disease Ontology:DOID:14219); coronary artery disease (Disease Ontology:DOID:3393); brain infarction (Disease Ontology:DOID:3454); primary hyperaldosteronism (Disease Ontology:DOID:446); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25598); (R-RNO-163560)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10082380;10692339;12809510;1740465;2671390;2682622;2824476;29600311;30845287;33884597;3840724;6582489;8253762;9063893;9139712", "class_list": "", "function": "FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor (By similarity)., [UniProtKB]; In acute mesenteric ischemia, Fabp2 levels are significantly increased and correlated with ischemic changes., [RefSeq, PubMed]; The aim of this experimental study was to determine if the type of termino-terminal anastomosis of the colon affect the process of healing of the intestinal mucosa and if the severity of the anastomotic leakage (AL) can be predicted based on the circulating level of intestinal fatty acid-binding protein., [RefSeq, PubMed]; The importance of serum intestinal fatty acid-binding protein for the early diagnosis of acute mesenteric ischemia.', trans 'Akut mezenter iskeminin erken tanisinda serum intestinal yag asidi baglayici proteininin onemi., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005902 microvillus", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0042594 response to starvation;GO:0032094 response to food;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P02693-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18090-1", "uniprot_id": [ { "id": "ADRB1_RAT", "url": "https://www.uniprot.org/uniprot/P18090", "type": "external" } ], "mass": 50472.0, "length": 466, "protein_name": "Beta-1 adrenergic receptor", "gene_name": "Adrb1", "organism": "Rat", "refseq_name": "beta-1 adrenergic receptor", "refseq_ac": [ { "id": "NP_036833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036833", "type": "external" } ], "gene_names_uniprotkb": "Adrb1; Adrb1r", "gene_names_refseq": "Adrb1; B1AR; RATB1AR", "protein_names_uniprotkb": "Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor", "protein_names_refseq": "adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); hypertension (Disease Ontology:DOID:10763); nephrosclerosis (Disease Ontology:DOID:11664); dilated cardiomyopathy (Disease Ontology:DOID:12930); low tension glaucoma (Disease Ontology:DOID:13544); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); aortic valve stenosis (Disease Ontology:DOID:1712); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); hyperglycemia (Disease Ontology:DOID:4195); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); periodontitis (Disease Ontology:DOID:824); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24925); (R-RNO-390696)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12391161;16316992;1695899;2167473;22673903;31433293;31553425;32471715;34555397;35053304", "class_list": "", "function": "Beta1-adrenergic receptor but not beta2 mediates osteogenic differentiation of bone marrow mesenchymal stem cells in normotensive and hypertensive rats., [RefSeq, PubMed]; G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (By similarity). Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:1695899). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction (By similarity). Also delivers proapoptotic signals in cardiomyocytes (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; O-GlcNAc transferase affects the signal transduction of beta1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of beta1 adrenoceptor., [RefSeq, PubMed]; Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; The authors demonstrate that endogenous beta1-adrenergic receptors at the Golgi apparatus in cardiac myocytes are required to stimulate hypertrophic Epac/PLCe-dependent phosphatidylinositol 4-phosphate hydrolysis at the Golgi, and that these intracellular beta1-adrenergic receptors can be accessed by physiological neurotransmitters, and synthetic b-blockers and agonists. Publication Status: Online-Only, [RefSeq, PubMed]; These results showed that prolonged action of adrenoceptor beta 1- autoantibodys significantly reduced the autophagy of myocardial tissues and H9c2 cardiomyocytes, and endoplasmic reticulum stress and its related apoptotic pathways were significantly activated., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 0, "mined_o_glycosites": 3, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031694 alpha-2A adrenergic receptor binding;GO:0030165 PDZ domain binding;GO:0004940 beta1-adrenergic receptor activity;GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0003061 positive regulation of the force of heart contraction by norepinephrine;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P18090-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100010010001.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6KC51-1", "uniprot_id": [ { "id": "ABLM2_RAT", "url": "https://www.uniprot.org/uniprot/Q6KC51", "type": "external" } ], "mass": 68010.0, "length": 612, "protein_name": "Actin-binding LIM protein 2", "gene_name": "Ablim2", "organism": "Rat", "refseq_name": "actin-binding LIM protein 2 isoform b", "refseq_ac": [ { "id": "NP_001001514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001514", "type": "external" } ], "gene_names_uniprotkb": "Ablim2", "gene_names_refseq": "Ablim2", "protein_names_uniprotkb": "Actin-binding LIM protein 2; Actin-binding LIM protein family member 2; abLIM-2", "protein_names_refseq": "abLIM-2; actin-binding LIM protein 2 isoform b; actin-binding LIM protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360958)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16005990;22673903", "class_list": "", "function": "May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The highest expression of both isoforms was observed in rat brain and eye and in mouse embryos. ABLIM2 protein was necessary for the normal functioning of neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6KC50", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030016 myofibril;GO:0005737 cytoplasm", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6KC51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30839-1", "uniprot_id": [ { "id": "AL3A2_RAT", "url": "https://www.uniprot.org/uniprot/P30839", "type": "external" } ], "mass": 54082.0, "length": 484, "protein_name": "Aldehyde dehydrogenase family 3 member A2", "gene_name": "Aldh3a2", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase family 3 member A2", "refseq_ac": [ { "id": "NP_113919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113919", "type": "external" } ], "gene_names_uniprotkb": "Aldh3a2; Aldh4", "gene_names_refseq": "Aldh3a2; Aldh4; FALDH", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member A2; 1.2.1.3; 1.2.1.94; Aldehyde dehydrogenase 4; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenase; msALDH", "protein_names_refseq": "alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 3A2; aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; fatty aldehyde dehydrogenase; microsomal aldehyde dehydrogenase; msALDH", "tax_id": 10116, "disease": "Sjogren-Larsson syndrome (Disease Ontology:DOID:14501)", "pathway": " (rno:65183); (R-RNO-389599); (R-RNO-9603798); (R-RNO-9609523); (R-RNO-9696270); (R-RNO-9696273); (R-RNO-9845614)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "1717467;29393594", "class_list": "", "function": "Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "7.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0046577 long-chain-alcohol oxidase activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046458 hexadecanal metabolic process;GO:0006631 fatty acid metabolic process;GO:0008544 epidermis development;GO:0006081 aldehyde metabolic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P30839-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62924-1", "uniprot_id": [ { "id": "AKA11_RAT", "url": "https://www.uniprot.org/uniprot/Q62924", "type": "external" } ], "mass": 124482.0, "length": 1129, "protein_name": "A-kinase anchor protein 11", "gene_name": "Akap11", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Akap11; Akap220", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchor protein 11; A-kinase anchor protein 220 kDa; AKAP 220; AKAP-11; PRKA11; Protein kinase A-anchoring protein 11", "protein_names_refseq": "", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis 8 (Disease Ontology:DOID:0110723); neuronal ceroid lipofuscinosis 8 northern epilepsy variant (Disease Ontology:DOID:0110724)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "22673903;8621616", "class_list": "", "function": "Binds to type II regulatory subunits of protein kinase A and anchors/targets them., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0008157 protein phosphatase 1 binding;GO:0051018 protein kinase A binding;GO:0019207 kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0003091 renal water homeostasis;GO:1903142 positive regulation of establishment of endothelial barrier;GO:0036010 protein localization to endosome;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62924-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05140-1", "uniprot_id": [ { "id": "AP180_RAT", "url": "https://www.uniprot.org/uniprot/Q05140", "type": "external" } ], "mass": 93519.0, "length": 915, "protein_name": "Clathrin coat assembly protein AP180", "gene_name": "Snap91", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snap91", "gene_names_refseq": "", "protein_names_uniprotkb": "Clathrin coat assembly protein AP180; 91 kDa synaptosomal-associated protein; Clathrin coat-associated protein AP180", "protein_names_refseq": "", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:65178); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10380931;10430869;10944104;16516836;16903783;18683930;21500857;22673903;28657654;8440257", "class_list": "", "function": "Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0019901 protein kinase binding;GO:0042169 SH2 domain binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0014069 postsynaptic density", "go_biological_process": "GO:1905445 positive regulation of clathrin coat assembly;GO:0051223 regulation of protein transport;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:2000331 regulation of terminal button organization;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q05140-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100010001001.111.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2Q0I9-1", "uniprot_id": [ { "id": "FNDC1_RAT", "url": "https://www.uniprot.org/uniprot/Q2Q0I9", "type": "external" } ], "mass": 194049.0, "length": 1779, "protein_name": "Fibronectin type III domain-containing protein 1", "gene_name": "Fndc1", "organism": "Rat", "refseq_name": "fibronectin type III domain-containing protein 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001033704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033704", "type": "external" } ], "gene_names_uniprotkb": "Fndc1; Ags8", "gene_names_refseq": "Fndc1", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 1; Activator of G protein signaling 8", "protein_names_refseq": "activator of G-protein signaling 8; fibronectin type III domain containing 1 protein; fibronectin type III domain-containing protein 1 isoform 2 precursor; fibronectin type III domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:308099)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16407149;16641100;19723622;22673903;27064407", "class_list": "", "function": "AGS8 is required for hypoxia-induced apoptosis of ardiomyocytes., [RefSeq, PubMed]; Activator of G protein signaling 8 (AGS8, KIAA1866) has been isolated from a rat heart model of repetitive transient ischemia. AGS8 appears to promote G protein signaling by a mechanism that involves direct interaction with G-protein betagamma [AGS8], [RefSeq, PubMed]; May be an activator of G protein signaling., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutations in Fndc1 gene is associated with Hypertension. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0001934 positive regulation of protein phosphorylation;GO:0071456 cellular response to hypoxia;GO:0010666 positive regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q2Q0I9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11497-1", "uniprot_id": [ { "id": "ACACA_RAT", "url": "https://www.uniprot.org/uniprot/P11497", "type": "external" } ], "mass": 265194.0, "length": 2345, "protein_name": "Acetyl-CoA carboxylase 1", "gene_name": "Acaca", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Acaca; Acac", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetyl-CoA carboxylase 1; 6.4.1.2; ACC-alpha; ACC1", "protein_names_refseq": "", "tax_id": 10116, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:60581); (R-RNO-196780); (R-RNO-200425); (R-RNO-75105)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "1346520;16396499;16760380;1688796;17218081;1974251;22673903;2565337;2566999;2567668;26394137;2900138;2901088;7910165;9029219", "class_list": "", "function": "Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1EC79;P97902", "ec_number_list": [ { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0009374 biotin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process;GO:0051289 protein homotetramerization;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P11497-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924N5-1", "uniprot_id": [ { "id": "ACBG1_RAT", "url": "https://www.uniprot.org/uniprot/Q924N5", "type": "external" } ], "mass": 80519.0, "length": 721, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG1", "gene_name": "Acsbg1", "organism": "Rat", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG1", "refseq_ac": [ { "id": "NP_599216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599216", "type": "external" } ], "gene_names_uniprotkb": "Acsbg1; Grlacs", "gene_names_refseq": "Acsbg1; Grlacs; Lpd", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG1; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 1; GR-LACS; Gonadotropin-regulated long chain acyl CoA synthetase", "protein_names_refseq": "gonadotropin-regulated long chain acyl CoA synthetase; lipidosin; long-chain-fatty-acid--CoA ligase ACSBG1", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (rno:171410); (R-RNO-75876)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11381125;16469493;22673903", "class_list": "", "function": "Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0051384 response to glucocorticoid;GO:0042759 long-chain fatty acid biosynthetic process;GO:0001552 ovarian follicle atresia", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q924N5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70478-1", "uniprot_id": [ { "id": "APC_RAT", "url": "https://www.uniprot.org/uniprot/P70478", "type": "external" } ], "mass": 310533.0, "length": 2842, "protein_name": "Adenomatous polyposis coli protein", "gene_name": "Apc", "organism": "Rat", "refseq_name": "adenomatous polyposis coli protein", "refseq_ac": [ { "id": "NP_036631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036631", "type": "external" } ], "gene_names_uniprotkb": "Apc", "gene_names_refseq": "Apc; RATAPC", "protein_names_uniprotkb": "Adenomatous polyposis coli protein; Protein APC", "protein_names_refseq": "APC, WNT signaling pathway regulator; WNT signaling pathway regulator; adenomatosis polyposis coli; adenomatous polyposis coli protein", "tax_id": 10116, "disease": "familial adenomatous polyposis (Disease Ontology:DOID:0050424); medulloblastoma (Disease Ontology:DOID:0050902); familial adenomatous polyposis 1 (Disease Ontology:DOID:0080409); hereditary desmoid disease (Disease Ontology:DOID:0111349); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); adenocarcinoma (Disease Ontology:DOID:299); acinar cell carcinoma (Disease Ontology:DOID:3025); gallbladder cancer (Disease Ontology:DOID:3121); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24205); (R-RNO-111465); (R-RNO-195253); (R-RNO-196299); (R-RNO-3769402); (R-RNO-4641262); (R-RNO-5689896)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "16641100;16815997;22673903;30934153;34003864;38843836;7846077;8563176", "class_list": "", "function": "Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats. Publication Status: Online-Only, [RefSeq, PubMed]; The miR-30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical., [RefSeq, PubMed]; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells (By similarity). Associates with both microtubules and actin filaments, components of the cytoskeleton (By similarity). Plays a role in mediating the organization of F-actin into ordered bundles (By similarity). Functions downstream of Rho GTPases and DIAPH1 to selectively stabilize microtubules (By similarity). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 42, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 25, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule", "go_biological_process": "GO:0001708 cell fate specification;GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0097305 response to alcohol;GO:0009798 axis specification;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P70478-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51647-1", "uniprot_id": [ { "id": "AL1A1_RAT", "url": "https://www.uniprot.org/uniprot/P51647", "type": "external" } ], "mass": 54459.0, "length": 501, "protein_name": "Aldehyde dehydrogenase 1A1", "gene_name": "Aldh1a1", "organism": "Rat", "refseq_name": "aldehyde dehydrogenase 1A1", "refseq_ac": [ { "id": "NP_071852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071852", "type": "external" } ], "gene_names_uniprotkb": "Aldh1a1; Aldh", "gene_names_refseq": "Ahd2; Aldh1a1; Aldh1; Aldh2", "protein_names_uniprotkb": "Aldehyde dehydrogenase 1A1; 1.2.1.19; 1.2.1.28; 1.2.1.36; 1.2.1.3; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; RALDH 1; RalDH1; Retinal dehydrogenase 1", "protein_names_refseq": "3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; RALDH 1; aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase 2; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, subfamily A1; aldehyde dehydrogenase, cytosolic; ralDH1; retinal dehydrogenase 1", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); pancreatic cancer (Disease Ontology:DOID:1793); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24188); (R-RNO-5365859); (R-RNO-70350); (R-RNO-71384)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "15623782;22673903;33400378;34502162;35909581;36535138;36587924;37816196;7832787;8543180;9059608;9218716;9240474", "class_list": "", "function": "ALDH2 attenuates ischemia and reperfusion injury through regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in diabetic cardiomyopathy., [RefSeq, PubMed]; Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage., [RefSeq, PubMed]; Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1. Publication Status: Online-Only, [RefSeq, PubMed]; Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute Cerebral Infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:15623782, PubMed:7832787). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (PubMed:7832787). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Loss of ALDH2 aggravates mitochondrial biogenesis disorder in cardiac myocytes induced by TAC., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09184", "ec_number_list": [ { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.94", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0001889 liver development;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P51647-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q794F9-1", "uniprot_id": [ { "id": "4F2_RAT", "url": "https://www.uniprot.org/uniprot/Q794F9", "type": "external" } ], "mass": 58072.0, "length": 527, "protein_name": "Amino acid transporter heavy chain SLC3A2", "gene_name": "Slc3a2", "organism": "Rat", "refseq_name": "amino acid transporter heavy chain SLC3A2 isoform 2", "refseq_ac": [ { "id": "NP_001258018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258018", "type": "external" } ], "gene_names_uniprotkb": "Slc3a2", "gene_names_refseq": "Mdu1; Slc3a2", "protein_names_uniprotkb": "Amino acid transporter heavy chain SLC3A2; 4F2 cell-surface antigen heavy chain; 4F2hc; Solute carrier family 3 member 2", "protein_names_refseq": "4F2 cell-surface antigen heavy chain; 4F2hc; amino acid transporter heavy chain SLC3A2 isoform 2; amino acid transporter heavy chain SLC3A2; antigen identified by monoclonal antibodies 4F2; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; solute carrier family 3 (amino acid transporter heavy chain), member 2", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung pleomorphic carcinoma (Disease Ontology:DOID:0080899); transitional cell carcinoma (Disease Ontology:DOID:2671); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:50567); (R-RNO-210991); (R-RNO-352230); (R-RNO-71240)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10.1039/D0MO00044B;10049700;10391916;11095508;12614332;15120633;15980244;21454685;22673903;23426681;24090084;27570548;34106099;38843836;9480885;9726963", "class_list": "glycogene;glycosylhydrolase", "function": "Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10049700, PubMed:10391916, PubMed:12614332, PubMed:15980244, PubMed:23426681, PubMed:9480885, PubMed:9726963). Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit (By similarity). Heterodimers formed by SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (By similarity). SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Taken together, these results suggest that system xc(-) plays a key role in the inflammatory reaction underlying experimental stroke. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 13, "disease_count": 7, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:1903801 L-leucine import across plasma membrane;GO:0005975 carbohydrate metabolic process;GO:0015804 neutral amino acid transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q794F9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M871-1", "uniprot_id": [ { "id": "FCMR_RAT", "url": "https://www.uniprot.org/uniprot/Q5M871", "type": "external" } ], "mass": 48055.0, "length": 426, "protein_name": "Immunoglobulin mu Fc receptor", "gene_name": "Fcmr", "organism": "Rat", "refseq_name": "immunoglobulin mu Fc receptor precursor", "refseq_ac": [ { "id": "NP_001014843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014843", "type": "external" } ], "gene_names_uniprotkb": "Fcmr; Faim3; Toso", "gene_names_refseq": "FAIM3g; Faim3; Fcmr; IgM FcR; Toso", "protein_names_uniprotkb": "Immunoglobulin mu Fc receptor; FAIM3g; Fas apoptotic inhibitory molecule 3; IgM FcR; Regulator of Fas-induced apoptosis Toso", "protein_names_refseq": "Fas apoptotic inhibitory molecule 3; Fc fragment of IgM receptor; IgM Fc fragment receptor; immunoglobulin mu Fc receptor precursor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso", "tax_id": 10116, "disease": "", "pathway": " (rno:548326)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (By similarity). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (By similarity). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001791 IgM binding;GO:0002172 high-affinity IgM receptor activity;GO:0001790 polymeric immunoglobulin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0002414 immunoglobulin transcytosis in epithelial cells;GO:0070229 negative regulation of lymphocyte apoptotic process;GO:0007165 signal transduction;GO:0002455 humoral immune response mediated by circulating immunoglobulin;GO:2001237 negative regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHK2-1", "uniprot_id": [ { "id": "CSKI1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHK2", "type": "external" } ], "mass": 150347.0, "length": 1430, "protein_name": "Caskin-1", "gene_name": "Caskin1", "organism": "Rat", "refseq_name": "caskin-1", "refseq_ac": [ { "id": "NP_542421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542421", "type": "external" } ], "gene_names_uniprotkb": "Caskin1", "gene_names_refseq": "Caskin1", "protein_names_uniprotkb": "Caskin-1; CASK-interacting protein 1", "protein_names_refseq": "cask-interacting protein 1; caskin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:140722)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12040031;19523119;22673903", "class_list": "", "function": "May link the scaffolding protein CASK to downstream intracellular effectors., [UniProtKB, UniProtKB, UniProtKB]; Proline-rich region of Caskin1 is biochemically functional, as it interacts with the adaptor protein Abl-interactor-2., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0098794 postsynapse", "go_biological_process": "GO:0007165 signal transduction;GO:0099151 regulation of postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHK2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88917-1", "uniprot_id": [ { "id": "AGRL1_RAT", "url": "https://www.uniprot.org/uniprot/O88917", "type": "external" } ], "mass": 166615.0, "length": 1515, "protein_name": "Adhesion G protein-coupled receptor L1", "gene_name": "Adgrl1", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor L1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_075251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075251", "type": "external" } ], "gene_names_uniprotkb": "Adgrl1; Cirl1; Cirl; Cl1; Lphn1", "gene_names_refseq": "Adgrl1; CL1BA; Lphn1", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L1; CIRL-1; Calcium-independent alpha-latrotoxin receptor 1; Latrophilin-1", "protein_names_refseq": "CIRL-1; adhesion G protein-coupled receptor L1 isoform 1 precursor; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:65096)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10958799;12270923;16641100;21724987;22262843;22333914;32996461;38843836;8798521;9208860;9261169;9830014;9920906", "class_list": "", "function": "Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis., [UniProtKB, PubMed, PubMed]; Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities., [RefSeq, PubMed]; Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex., [RefSeq, PubMed]; Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "O09026;O35818;O88916", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0015643 toxic substance binding;GO:0050839 cell adhesion molecule binding;GO:0016524 latrotoxin receptor activity;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030426 growth cone;GO:0045202 synapse", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O88917-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25304-1", "uniprot_id": [ { "id": "AGRIN_RAT", "url": "https://www.uniprot.org/uniprot/P25304", "type": "external" } ], "mass": 208646.0, "length": 1959, "protein_name": "Agrin", "gene_name": "Agrn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Agrn; Agrin", "gene_names_refseq": "", "protein_names_uniprotkb": "Agrin", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital myasthenic syndrome 8 (Disease Ontology:DOID:0110657)", "pathway": " (rno:25592); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-3000178); (R-RNO-975634); (R-RNO-9769739); (R-RNO-9913351)", "pathway_count": 8, "publication_count": 16, "publication_id_list": "11161480;1326608;17586728;1851019;18775496;19524020;20471381;20505824;20566625;20980386;22302937;38843836;7472435;8398142;8653787;8693000", "class_list": "", "function": "Depending on alternative splicing and post-translational modifications, it has a role in different processes, including formation and maintenance of the neuromuscular junction, regulation of neurite outgrowth, and positive regulation of cartilage formation through alpha-dystroglycan binding and up-regulation of SOX9., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This transmembrane agrin (TM-agrin) isoform, the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases., [UniProtKB]; Is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Isoform 1, isoform 4, isoform 5 and isoform 6: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms., [UniProtKB]; This released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 4, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 34, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q63034", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity;GO:0043395 heparan sulfate proteoglycan binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1902667 regulation of axon guidance;GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0007009 plasma membrane organization;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P25304-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08413-1", "uniprot_id": [ { "id": "KCC2B_RAT", "url": "https://www.uniprot.org/uniprot/P08413", "type": "external" } ], "mass": 60402.0, "length": 542, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit beta", "gene_name": "Camk2b", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3", "refseq_ac": [ { "id": "NP_001035815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035815", "type": "external" } ], "gene_names_uniprotkb": "Camk2b; Camk2g", "gene_names_refseq": "Camk2b; Ck2b", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit beta; 2.7.11.17; CaM kinase II subunit beta; CaMK-II subunit beta", "protein_names_refseq": "Ca++/calmodulin-dependent protein kinase II beta subunit; caM kinase II subunit beta; caM-kinase II beta chain; caMK-II subunit beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3; calcium/calmodulin-dependent protein kinase type II subunit beta", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 54 (Disease Ontology:DOID:0080230); heart conduction disease (Disease Ontology:DOID:10273)", "pathway": " (rno:24245); (R-RNO-3371571); (R-RNO-399719); (R-RNO-438066); (R-RNO-5578775); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-877300); (R-RNO-936837)", "pathway_count": 9, "publication_count": 16, "publication_id_list": "11182241;11972023;12873385;15312654;16891908;17272343;22579289;22673903;27611779;29675826;30662904;3470758;36041587;38843836;9724800;9768845", "class_list": "", "function": "Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:12873385, PubMed:15312654). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise (PubMed:17272343). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-134' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Effects of Camk2b Overexpression and Underexpression on the Proteome of Rat Hippocampal Neurons., [RefSeq, PubMed]; Significantly upregulated the expression levels of CaMKIIbeta. Publication Status: Online-Only, [RefSeq, PubMed]; These data establish a potential signaling pathway of Ca2+-CaMKII-CREB in neuronal activation. Publication Status: Online-Only, [RefSeq, PubMed]; This study provides the first evidence to show that CaMKIIbeta interacts with drebrin in dendritic spines., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0002030 inhibitory G protein-coupled receptor phosphorylation;GO:0060466 activation of meiosis involved in egg activation;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P08413-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EST6-1", "uniprot_id": [ { "id": "AN32B_RAT", "url": "https://www.uniprot.org/uniprot/Q9EST6", "type": "external" } ], "mass": 31061.0, "length": 272, "protein_name": "Acidic leucine-rich nuclear phosphoprotein 32 family member B", "gene_name": "Anp32b", "organism": "Rat", "refseq_name": "acidic leucine-rich nuclear phosphoprotein 32 family member B", "refseq_ac": [ { "id": "NP_571986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571986", "type": "external" } ], "gene_names_uniprotkb": "Anp32b; Pal31", "gene_names_refseq": "Anp32b; PAL31", "protein_names_uniprotkb": "Acidic leucine-rich nuclear phosphoprotein 32 family member B; Proliferation-related acidic leucine-rich protein PAL31", "protein_names_refseq": "acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic leucine-rich nuclear phosphoprotein 32 family member B; proliferation-related acidic leucine-rich protein PAL31", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:170724)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10913355;11162633;15895553;16499868;22673903;25034417;29393594", "class_list": "", "function": "Data suggest that PAL31upregulation might be beneficial after spinal cord injury. Reactive gliosis might become a good target for future therapeutic interventions. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle (PubMed:11162633). As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:16499868). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (By similarity). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Multifunctional protein that is involved in the regulation of many processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046827 positive regulation of protein export from nucleus;GO:0042981 regulation of apoptotic process;GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9EST6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1X8-1", "uniprot_id": [ { "id": "AAK1_RAT", "url": "https://www.uniprot.org/uniprot/P0C1X8", "type": "external" } ], "mass": 103761.0, "length": 962, "protein_name": "AP2-associated protein kinase 1", "gene_name": "Aak1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aak1", "gene_names_refseq": "", "protein_names_uniprotkb": "AP2-associated protein kinase 1; 2.7.11.1; Adaptor-associated kinase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:500244); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11877461;22673903", "class_list": "", "function": "Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877461). Preferentially, may phosphorylate substrates on threonine residues (By similarity). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (By similarity). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (By similarity). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005112 Notch binding;GO:0035612 AP-2 adaptor complex binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031252 cell leading edge;GO:0043195 terminal bouton", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0032880 regulation of protein localization;GO:0045747 positive regulation of Notch signaling pathway;GO:0050821 protein stabilization;GO:2000369 regulation of clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C1X8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00657-1", "uniprot_id": [ { "id": "CSPG4_RAT", "url": "https://www.uniprot.org/uniprot/Q00657", "type": "external" } ], "mass": 251909.0, "length": 2326, "protein_name": "Chondroitin sulfate proteoglycan 4", "gene_name": "Cspg4", "organism": "Rat", "refseq_name": "chondroitin sulfate proteoglycan 4 precursor", "refseq_ac": [ { "id": "NP_112284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112284", "type": "external" } ], "gene_names_uniprotkb": "Cspg4; Ng2", "gene_names_refseq": "Cspg4; Ng2", "protein_names_uniprotkb": "Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan NG2; HSN tumor-specific antigen", "protein_names_refseq": "HSN tumor-specific antigen; chondroitin sulfate proteoglycan 4 precursor; chondroitin sulfate proteoglycan NG2; membrane-spanning proteoglycan NG2", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:81651); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10358027;10889192;10967549;11493670;12220645;12514214;15181153;15504744;1906475;2269670;27498042;27582000;32967214;33822814;34102261;38843836;8077056;8305732;8590808;8824254;9099729;9281375", "class_list": "", "function": "Age-related changes in NG2-expressing telocytes of rat stomach. Publication Status: Online-Only, [RefSeq, PubMed]; Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential mesenchymal progenitor cells marker., [RefSeq, PubMed]; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; The Function of NG2/CSPG4-expressing Cells in the Rat Spinal Cord Injury: An Immunoelectron Microscopy Study., [RefSeq, PubMed]; These findings indicate that Col VI provided a characteristic microenvironment in the GOR and that NG2-Col VI interactions may regulate the differentiation of osteoblast lineages prior to terminal maturation., [RefSeq, PubMed]", "predicted_glycosites": 18, "predicted_n_glycosites": 15, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019901 protein kinase binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0001726 ruffle;GO:0031258 lamellipodium membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0016322 neuron remodeling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q00657-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6S7-1", "uniprot_id": [ { "id": "ANS1B_RAT", "url": "https://www.uniprot.org/uniprot/P0C6S7", "type": "external" } ], "mass": 139207.0, "length": 1260, "protein_name": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B", "gene_name": "Anks1b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Anks1b", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and sterile alpha motif domain-containing protein 1B; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; E2A-PBX1-associated protein; EB-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15169875;17334360;22673903", "class_list": "", "function": "Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0015030 Cajal body", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0099565 chemical synaptic transmission, postsynaptic;GO:1900383 regulation of synaptic plasticity by receptor localization to synapse;GO:0097120 receptor localization to synapse;GO:0099527 postsynapse to nucleus signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C6S7-1", "record_type": "protein", "filter_code": "0000000.0100100.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M3G7-1", "uniprot_id": [ { "id": "AKP13_RAT", "url": "https://www.uniprot.org/uniprot/F1M3G7", "type": "external" } ], "mass": 301403.0, "length": 2760, "protein_name": "A-kinase anchor protein 13", "gene_name": "Akap13", "organism": "Rat", "refseq_name": "A-kinase anchor protein 13", "refseq_ac": [ { "id": "NP_001099741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099741", "type": "external" } ], "gene_names_uniprotkb": "Akap13; Rt13", "gene_names_refseq": "AKAP-13; AKAP-Lbc; Akap13", "protein_names_uniprotkb": "A-kinase anchor protein 13; AKAP-13; AKAP-Lbc", "protein_names_refseq": "A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; protein kinase A anchoring protein Rt31", "tax_id": 10116, "disease": "", "pathway": " (rno:293024); (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11696353;17537920;20139090;22673903;23090968;23716597;24269843;25892096;29393594", "class_list": "", "function": "Activation of IKKbeta within the AKAP-Lbc complex promotes NF-kappaB-dependent production of interleukin-6, which in turn enhances fetal gene expression and cardiomyocyte growth., [RefSeq, PubMed]; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:17537920). May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G protein-coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (PubMed:20139090). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (By similarity). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920). Required for normal adaptive cardiac hypertrophy in response to pressure overload (By similarity). Plays a role in osteogenesis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; These findings identify AKAP-Lbc as a key Rho-guanine nucleotide exchange factor modulating profibrotic responses in cardiac fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHU6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0043410 positive regulation of MAPK cascade;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043406 positive regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "F1M3G7-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05764-1", "uniprot_id": [ { "id": "ADDB_RAT", "url": "https://www.uniprot.org/uniprot/Q05764", "type": "external" } ], "mass": 80593.0, "length": 725, "protein_name": "Beta-adducin", "gene_name": "Add2", "organism": "Rat", "refseq_name": "beta-adducin isoform a", "refseq_ac": [ { "id": "NP_001103350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103350", "type": "external" } ], "gene_names_uniprotkb": "Add2", "gene_names_refseq": "Add2; beta-ADD", "protein_names_uniprotkb": "Beta-adducin; Adducin-63; Erythrocyte adducin subunit beta", "protein_names_refseq": "adducin 2 (beta); adducin beta; adducin-63; beta-adducin isoform a; beta-adducin; erythrocyte adducin subunit beta", "tax_id": 10116, "disease": "spastic quadriplegic cerebral palsy 3 (Disease Ontology:DOID:0081361); hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); hypertension (Disease Ontology:DOID:10763); cerebral palsy (Disease Ontology:DOID:1969); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (rno:24171); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10602987;18634768;2059221;21150638;22673903;26639316", "class_list": "", "function": "Darpp32 interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system. Publication Status: Online-Only, [RefSeq, PubMed]; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity)., [UniProtKB]; Mutations in the beta subunit of the adducin protein result in damage to renal artery myogenic tone and this is associated with renal damage as manifest by proteinuria., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 29, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping;GO:0051017 actin filament bundle assembly;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q05764-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21932-1", "uniprot_id": [ { "id": "ADCY3_RAT", "url": "https://www.uniprot.org/uniprot/P21932", "type": "external" } ], "mass": 128936.0, "length": 1144, "protein_name": "Adenylate cyclase type 3", "gene_name": "Adcy3", "organism": "Rat", "refseq_name": "adenylate cyclase type 3", "refseq_ac": [ { "id": "NP_570135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570135", "type": "external" } ], "gene_names_uniprotkb": "Adcy3", "gene_names_refseq": "Adcy3", "protein_names_uniprotkb": "Adenylate cyclase type 3; 4.6.1.1; AC-III; AC3; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3", "protein_names_refseq": "AC-III; AC3; ATP pyrophosphate-lyase 3; adenylate cyclase type 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; type III adenylyl cyclase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); major depressive disorder (Disease Ontology:DOID:1470); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:64508); (R-RNO-163615); (R-RNO-170660); (R-RNO-170670); (R-RNO-418597); (R-RNO-5610787)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "15705663;1633161;2255909;24363043;25908845;35625651", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:1633161, PubMed:2255909, PubMed:24363043). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (PubMed:2255909). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia. Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation (By similarity). Required for normal sperm motility and normal male fertility (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet., [UniProtKB, UniProtKB]; Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0030317 flagellated sperm motility;GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21932-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVC7-1", "uniprot_id": [ { "id": "AKAP6_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVC7", "type": "external" } ], "mass": 254352.0, "length": 2314, "protein_name": "A-kinase anchor protein 6", "gene_name": "Akap6", "organism": "Rat", "refseq_name": "A-kinase anchor protein 6", "refseq_ac": [ { "id": "NP_072140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072140", "type": "external" } ], "gene_names_uniprotkb": "Akap6", "gene_names_refseq": "Akap6; mAkap", "protein_names_uniprotkb": "A-kinase anchor protein 6; AKAP-6; PRKA6; Protein kinase A-anchoring protein 6; mAKAP", "protein_names_refseq": "A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; AKAP-6; PRKA6; protein kinase A-anchoring protein 6", "tax_id": 10116, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); anorexia nervosa (Disease Ontology:DOID:8689)", "pathway": " (rno:64553)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10413680;22673903;29522762;29733383;30523159;32933333", "class_list": "", "function": "Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In cardiac myocytes, PDE4 insulates a mAKAPbeta-targeted PKA pool at the nuclear envelope that prevents nuclear PKA activation upon beta2-AR stimulation., [RefSeq, PubMed]; MAKAPbeta signalosomes serve to bidirectionally regulate the nuclear-cytoplasmic localization of class IIa HDACs.[, [RefSeq, PubMed]; Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure., [RefSeq, PubMed]; These results highlight the importance of mAKAPbeta signalosomes for regulating MEF2D activity in striated muscle, affirming mAKAPbeta as a nodal regulator in the myocyte intracellular signaling network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0044325 transmembrane transporter binding;GO:0008179 adenylate cyclase binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1901897 regulation of relaxation of cardiac muscle;GO:0007194 negative regulation of adenylate cyclase activity;GO:0030307 positive regulation of cell growth;GO:0071320 cellular response to cAMP;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WVC7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1K9-1", "uniprot_id": [ { "id": "ADA17_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1K9", "type": "external" } ], "mass": 93017.0, "length": 827, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "Adam17", "organism": "Rat", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 17 precursor", "refseq_ac": [ { "id": "NP_064702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064702", "type": "external" } ], "gene_names_uniprotkb": "Adam17; Tace", "gene_names_refseq": "Adam17; TACE", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 17; 3.4.24.86; ADAM 17; TNF-alpha convertase; TNF-alpha-converting enzyme", "protein_names_refseq": "ADAM 17; TNF-alpha convertase; TNF-alpha-converting enzyme; a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); disintegrin and metalloproteinase domain-containing protein 17 precursor; disintegrin and metalloproteinase domain-containing protein 17", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); neonatal inflammatory skin and bowel disease 1 (Disease Ontology:DOID:0061192); Alzheimer's disease (Disease Ontology:DOID:10652); thoracic aortic aneurysm (Disease Ontology:DOID:14004); atopic dermatitis (Disease Ontology:DOID:3310); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:57027); (R-RNO-193692); (R-RNO-75893)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "21411748;22673903;25232008;25371038;26479776;32917219;33275250;33492555;33660945;35909160;36586043", "class_list": "", "function": "Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia., [RefSeq, PubMed]; Influences of miR-708 on cerebral ischemia-reperfusion injury through targeted regulation of ADAM17., [RefSeq, PubMed]; MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression., [RefSeq, PubMed]; Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease., [RefSeq, PubMed]; Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (By similarity). Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 (By similarity). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.86", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005178 integrin binding;GO:0008237 metallopeptidase activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:0048679 regulation of axon regeneration;GO:1990910 response to hypobaric hypoxia;GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z1K9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23565-1", "uniprot_id": [ { "id": "AINX_RAT", "url": "https://www.uniprot.org/uniprot/P23565", "type": "external" } ], "mass": 56115.0, "length": 505, "protein_name": "Alpha-internexin", "gene_name": "Ina", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ina; Inexa", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-internexin; Alpha-Inx", "protein_names_refseq": "", "tax_id": 10116, "disease": "pheochromocytoma/paraganglioma syndrome 7 (Disease Ontology:DOID:0061222); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:24503)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1717465;18683930;22673903;2311576;38843836;9388258", "class_list": "", "function": "Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005882 intermediate filament;GO:0098794 postsynapse;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005883 neurofilament", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:1990830 cellular response to leukemia inhibitory factor;GO:0042246 tissue regeneration;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P23565-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21396-1", "uniprot_id": [ { "id": "AOFA_RAT", "url": "https://www.uniprot.org/uniprot/P21396", "type": "external" } ], "mass": 59508.0, "length": 526, "protein_name": "Amine oxidase [flavin-containing] A", "gene_name": "Maoa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Maoa", "gene_names_refseq": "", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] A; 1.4.3.21; 1.4.3.4; MAO-A; Monoamine oxidase type A", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Brunner Syndrome (Disease Ontology:DOID:0060693); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574); panic disorder (Disease Ontology:DOID:594)", "pathway": " (R-RNO-141333); (R-RNO-181430); (R-RNO-379397); (R-RNO-379398); (R-RNO-379401); (R-RNO-380612)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "1368522;15050826;1526120;18391214;20493079;22673903;9162023", "class_list": "", "function": "Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:9162023). Preferentially oxidizes serotonin (PubMed:20493079). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (PubMed:18391214)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63817", "ec_number_list": [ { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0051378 serotonin binding;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042443 phenylethylamine metabolic process;GO:0042428 serotonin metabolic process;GO:0042420 dopamine catabolic process;GO:0009967 positive regulation of signal transduction;GO:0042424 catecholamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P21396-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70127-1", "uniprot_id": [ { "id": "ABCBB_RAT", "url": "https://www.uniprot.org/uniprot/O70127", "type": "external" } ], "mass": 146258.0, "length": 1321, "protein_name": "Bile salt export pump", "gene_name": "Abcb11", "organism": "Rat", "refseq_name": "bile salt export pump", "refseq_ac": [ { "id": "NP_113948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113948", "type": "external" } ], "gene_names_uniprotkb": "Abcb11; Bsep; Spgp", "gene_names_refseq": "Abcb11; Bsep; Spgp", "protein_names_uniprotkb": "Bile salt export pump; 7.6.2.-; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein", "protein_names_refseq": "ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; bile salt export pump; sister of P-glycoprotein", "tax_id": 10116, "disease": "progressive familial intrahepatic cholestasis 2 (Disease Ontology:DOID:0070222); benign recurrent intrahepatic cholestasis 2 (Disease Ontology:DOID:0070232); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:83569); (R-RNO-159418); (R-RNO-193368)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "11113123;15121884;15159385;15901796;16332456;17082223;18245269;18829893;18985798;21454685;22262466;22673903;24643070;30068870;31746430;9545351", "class_list": "", "function": "Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:15901796, PubMed:16332456, PubMed:17082223, PubMed:18985798, PubMed:9545351). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In conclusion, our data supports the hypothesis that isoniazid can induce liver injury via the down-regulation of hepatic efflux transporters BSEP and MRP2, and the SIRT1/FXR pathway may be the primary regulator with regard to the expression of transporters and the biosynthesis of bile acids in the liver., [RefSeq, PubMed]; Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicininduced liver injury in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 4, "mined_n_glycosites": 4, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015126 canalicular bile acid transmembrane transporter activity;GO:0015432 ABC-type bile acid transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006979 response to oxidative stress;GO:0045471 response to ethanol;GO:0055085 transmembrane transport;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "O70127-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88498-1", "uniprot_id": [ { "id": "B2L11_RAT", "url": "https://www.uniprot.org/uniprot/O88498", "type": "external" } ], "mass": 22056.0, "length": 196, "protein_name": "Bcl-2-like protein 11", "gene_name": "Bcl2l11", "organism": "Rat", "refseq_name": "bcl-2-like protein 11", "refseq_ac": [ { "id": "NP_741985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741985", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l11; Bim; Bod", "gene_names_refseq": "Bcl2l11; BimL; Bim; Bod", "protein_names_uniprotkb": "Bcl-2-like protein 11; Bcl-2-related ovarian death protein; Bcl2-L-11; Bcl2-interacting mediator of cell death", "protein_names_refseq": "BCL2-like 11 (apoptosis facilitator); Bcl-2 related apoptotic gene product BimL; bcl-2-like protein 11; bcl-2-related ovarian death protein; bcl2-interacting mediator of cell death", "tax_id": 10116, "disease": "", "pathway": " (rno:64547); (R-RNO-111446); (R-RNO-111453); (R-RNO-193648)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "15486195;21478148;21984578;22673903;27511131;29048431;31058341;32605511;35036441;9731710", "class_list": "", "function": "Effects and Mechanism of Oxymatrine Combined with Compound Yinchen Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Induces apoptosis and anoikis., [UniProtKB, PubMed]; MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2., [RefSeq, PubMed]; Our study demonstrates that miR-25 downregulation inhibits cardiomyocytes proliferation and migration...by targeting Bim, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88497;Q9WUI8", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0001701 in utero embryonic development;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88498-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88618-1", "uniprot_id": [ { "id": "FTCD_RAT", "url": "https://www.uniprot.org/uniprot/O88618", "type": "external" } ], "mass": 58914.0, "length": 541, "protein_name": "Formimidoyltransferase-cyclodeaminase", "gene_name": "Ftcd", "organism": "Rat", "refseq_name": "formimidoyltransferase-cyclodeaminase", "refseq_ac": [ { "id": "NP_446019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446019", "type": "external" } ], "gene_names_uniprotkb": "Ftcd", "gene_names_refseq": "Ftcd", "protein_names_uniprotkb": "Formimidoyltransferase-cyclodeaminase; 58 kDa microtubule-binding protein; FTCD; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase-cyclodeaminase; Glutamate formiminotransferase; Glutamate formyltransferase", "protein_names_refseq": "58 kDa microtubule-binding protein; formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase", "tax_id": 10116, "disease": "glutamate formiminotransferase deficiency (Disease Ontology:DOID:0111679)", "pathway": " (rno:89833); (R-RNO-70921)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12160147;15272307;17470791;22673903;9677387;9837973", "class_list": "", "function": "Binds and promotes bundling of vimentin filaments originating from the Golgi., [UniProtKB, PubMed]; Determination of the FTCD structure by X-ray crystallography and electron cryomicroscopy revealed that the eight subunits, each composed of distinct FT and CD domains, are arranged like a square doughnut, [RefSeq, PubMed]; FTCD is a potent modulator of the vimentin IF cytoskeleton, [RefSeq, PubMed]; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKB7", "ec_number_list": [ { "id": "2.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.5", "type": "external" }, { "id": "4.3.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.4", "type": "external" } ], "go_molecular_function": "GO:0008017 microtubule binding;GO:0005542 folic acid binding;GO:0019215 intermediate filament binding;GO:0030409 glutamate formimidoyltransferase activity;GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005814 centriole", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88618-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88788-1", "uniprot_id": [ { "id": "AG10B_RAT", "url": "https://www.uniprot.org/uniprot/O88788", "type": "external" } ], "mass": 55574.0, "length": 474, "protein_name": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "gene_name": "Alg10b", "organism": "Rat", "refseq_name": "dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase", "refseq_ac": [ { "id": "NP_620801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620801", "type": "external" } ], "gene_names_uniprotkb": "Alg10b; Kcr1", "gene_names_refseq": "Alg10b; Alg10; KCR1", "protein_names_uniprotkb": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; 2.4.1.256; Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-B; Asparagine-linked glycosylation protein 10 homolog B; Potassium channel regulator 1", "protein_names_refseq": "alpha-1,2-glucosyltransferase ALG10-A; alpha-2-glucosyltransferase ALG10-B; asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase); asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B; asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog; asparagine-linked glycosylation protein 10 homolog B; dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; potassium channel regulator 1; putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; putative alpha-1,2-glucosyltransferase ALG10-B", "tax_id": 10116, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); long QT syndrome 2 (Disease Ontology:DOID:0110645)", "pathway": " (rno:245960)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14525949;18231597;29393594;41018975;9722534", "class_list": "glycogene;glycosyltransferase", "function": "Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol., [UniProtKB, UniProtKB]; Observations demonstrate for the first time that KCR1 modulates I(HCN2)/I(f) channel gating and indicate that KCR1 serves as a regulator of cardiac automaticity Erratum:[PLoS One. 2012;7(8): doi/10.1371/annotation/ff27c2a4-7732-4c32-88da-c412f1cced0c] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.256", "type": "external" } ], "go_molecular_function": "GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 41, "hit_score": 0.8, "record_id": "O88788-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88923-7", "uniprot_id": [ { "id": "AGRL2_RAT", "url": "https://www.uniprot.org/uniprot/O88923", "type": "external" } ], "mass": 166729.0, "length": 1487, "protein_name": "Adhesion G protein-coupled receptor L2", "gene_name": "Adgrl2", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor L2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001177404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177404", "type": "external" } ], "gene_names_uniprotkb": "Adgrl2; Cirl2; Cl2; Lphn2", "gene_names_refseq": "Adgrl2; Cirl-2; Cirl2; Cl2ac; Lphn2", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L2; CIRL-2; Calcium-independent alpha-latrotoxin receptor 2; Latrophilin-2", "protein_names_refseq": "adhesion G protein-coupled receptor L2 isoform 2 precursor; calcium-independent alpha-latrotoxin receptor 2; calcium-independent alpha-latrotoxin receptor homolog 2; latrophilin-2", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)", "pathway": " (rno:171447)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10026162;21454685;22673903;38843836;9830014", "class_list": "", "function": "Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis., [UniProtKB, PubMed]; Orphan adhesion G protein-coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Following G protein-coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity. Specifically mediates the establishment of perforant-path synapses on CA1-region pyramidal neurons in the hippocampus. Localizes to postsynaptic spines in excitatory synapses in the S.lacunosum-moleculare and interacts with presynaptic cell adhesion molecules, such as teneurins, promoting synapse formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O88918;O88919;O88920;O88921;O88922;Q9Z174", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030246 carbohydrate binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0050808 synapse organization;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O88923-7", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07943-1", "uniprot_id": [ { "id": "ALDR_RAT", "url": "https://www.uniprot.org/uniprot/P07943", "type": "external" } ], "mass": 35797.0, "length": 316, "protein_name": "Aldo-keto reductase family 1 member B1", "gene_name": "Akr1b1", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member B1", "refseq_ac": [ { "id": "NP_036630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036630", "type": "external" } ], "gene_names_uniprotkb": "Akr1b1; Akr1b4; Aldr1", "gene_names_refseq": "ALDRED; ALR-P-I; Akr1b1; Akr1b3; Akr1b4; Aldr1; Alr; RATALDRED", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member B1; 1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54; AR; Aldehyde reductase; Aldose reductase", "protein_names_refseq": "AR; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B; aldose reductase", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 56 (Disease Ontology:DOID:0080226); stomach cancer (Disease Ontology:DOID:10534); allergic disease (Disease Ontology:DOID:1205); arteriosclerosis (Disease Ontology:DOID:2349); hyperglycemia (Disease Ontology:DOID:4195); hypokalemia (Disease Ontology:DOID:4500); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:24192); (R-RNO-196108); (R-RNO-5652227)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "1748296;21454685;22673903;28386557;29948725;3111886;31604989;38188141;7498172", "class_list": "", "function": "AKR1B1 played a vital role in astrocyte proliferation and energy metabolism induced by spinal cord injury. Review article, [RefSeq, PubMed]; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls)., [UniProtKB, UniProtKB]; Coincubation of cells with epalrestat prevented the signaling changes and renal cell injury induced by high glucose. Thus, aldose reductase inhibition represents a potential therapeutic strategy to prevent Diabetic nephropathy Erratum:[Biomed Res Int. 2019 Aug 22;2019:9406241. doi: 10.1155/2019/9406241. PMID: 31534968], [RefSeq, PubMed]; Proteomics-based screening of AKR1B1 as a therapeutic target and validation study for sepsis-associated acute kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.122", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0043795 glyceraldehyde oxidoreductase activity;GO:0047939 L-glucuronate reductase activity;GO:0036130 prostaglandin H2 endoperoxidase reductase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0042629 mast cell granule", "go_biological_process": "GO:0006060 sorbitol metabolic process;GO:0001523 retinoid metabolic process;GO:0003091 renal water homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0001894 tissue homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12785-1", "uniprot_id": [ { "id": "FAS_RAT", "url": "https://www.uniprot.org/uniprot/P12785", "type": "external" } ], "mass": 272650.0, "length": 2505, "protein_name": "Fatty acid synthase", "gene_name": "Fasn", "organism": "Rat", "refseq_name": "fatty acid synthase", "refseq_ac": [ { "id": "NP_059028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059028", "type": "external" } ], "gene_names_uniprotkb": "Fasn", "gene_names_refseq": "Fasn", "protein_names_uniprotkb": "Fatty acid synthase; 2.3.1.85; Type I FAS", "protein_names_refseq": "fatty acid synthase; type I FAS", "tax_id": 10116, "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:50671); (R-RNO-199220); (R-RNO-75105)", "pathway_count": 3, "publication_count": 23, "publication_id_list": "12926246;1339331;15240697;15715522;16054098;16969344;1736293;18096506;18683930;22673903;2313386;2717611;2891707;2915923;29393594;3109907;31465767;35210136;37914358;38824236;8250834;8756713;9405069", "class_list": "", "function": "2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells., [RefSeq, PubMed]; Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis., [RefSeq, PubMed]; Fatty acid synthase (Fasn) inhibits the expression levels of immune response genes via alteration of alternative splicing in islet cells., [RefSeq, PubMed]; Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension revealed by inhibition of FASN. Inhibition of FAS decreases Right ventricle hypertrophy and improves cardiac function associated with Pulmonary hypertension by perking up metabolic functions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09187;O09190;Q63577;Q64717", "ec_number_list": [ { "id": "2.7.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.7", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "1.6.5.10", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.10", "type": "external" }, { "id": "1.3.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031177 phosphopantetheine binding;GO:0036094 small molecule binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042470 melanosome;GO:0042587 glycogen granule", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0006631 fatty acid metabolic process;GO:0007584 response to nutrient;GO:0008610 lipid biosynthetic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "P12785-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14669-1", "uniprot_id": [ { "id": "ANXA3_RAT", "url": "https://www.uniprot.org/uniprot/P14669", "type": "external" } ], "mass": 36363.0, "length": 324, "protein_name": "Annexin A3", "gene_name": "Anxa3", "organism": "Rat", "refseq_name": "annexin A3", "refseq_ac": [ { "id": "NP_036955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036955", "type": "external" } ], "gene_names_uniprotkb": "Anxa3; Anx3", "gene_names_refseq": "Anx3; Anxa3; LC3; LRRGT00047", "protein_names_uniprotkb": "Annexin A3; 35-alpha calcimedin; Annexin III; Annexin-3; Lipocortin III; PAP-III; Placental anticoagulant protein III", "protein_names_refseq": "35-alpha calcimedin; Annexin III (Lipocortin III); PAP-III; annexin A3; annexin-3; lipocortin III; placental anticoagulant protein III", "tax_id": 10116, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:25291)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21454685;22673903;2968983;30456911;33167086;33779883;34221002;35118791", "class_list": "", "function": "Annexin A3 as a Marker Protein for Microglia in the Central Nervous System of Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitor of phospholipase A2, also possesses anti-coagulant properties., [UniProtKB]; NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting with LC3., [RefSeq, PubMed]; Our study provides evidence that the downregulation of ANXA3 promotes the repair and healing of myocardial tissues by activating the PI3K/Akt signaling pathway., [RefSeq, PubMed]; Regulation of total LC3 levels by angiotensin II in vascular smooth muscle cells., [RefSeq, PubMed]; [Effects of high-load exercise induced skeletal muscle injury on autophagy ultrastructure and Beclin1 and LC3-II / I in rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q642C2", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0019834 phospholipase A2 inhibitor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0043312 neutrophil degranulation;GO:0006909 phagocytosis;GO:0010595 positive regulation of endothelial cell migration;GO:0021766 hippocampus development;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14669-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16067-1", "uniprot_id": [ { "id": "ANPRB_RAT", "url": "https://www.uniprot.org/uniprot/P16067", "type": "external" } ], "mass": 117127.0, "length": 1047, "protein_name": "Atrial natriuretic peptide receptor 2", "gene_name": "Npr2", "organism": "Rat", "refseq_name": "atrial natriuretic peptide receptor 2 precursor", "refseq_ac": [ { "id": "NP_446290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446290", "type": "external" } ], "gene_names_uniprotkb": "Npr2", "gene_names_refseq": "GC-B; NPR-B; Npr2", "protein_names_uniprotkb": "Atrial natriuretic peptide receptor 2; 4.6.1.2; ANP-B; ANPR-B; Atrial natriuretic peptide receptor type B; GC-B; Guanylate cyclase B; NPR-B", "protein_names_refseq": "ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2 precursor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B", "tax_id": 10116, "disease": "Miura type epiphyseal chondrodysplasia (Disease Ontology:DOID:0070316); bone development disease (Disease Ontology:DOID:0080006); acromesomelic dysplasia, Maroteaux type (Disease Ontology:DOID:0080050); essential hypertension (Disease Ontology:DOID:10825); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (rno:116564); (R-RNO-5578768)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "20977274;2570641;27496871;27557795;28743500;28964968;37774352;9624142", "class_list": "", "function": "C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation., [RefSeq, PubMed]; Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats., [RefSeq, PubMed]; Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclasedagger., [RefSeq, PubMed]; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro., [RefSeq, PubMed]; We conclude that FGF rapidly inactivates GC-B by a reversible dephosphorylation mechanism, which may contribute to the signaling network by which activated FGFR3 causes dwarfism., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0045202 synapse", "go_biological_process": "GO:0030540 female genitalia development;GO:0035483 gastric emptying;GO:0001964 startle response;GO:0060466 activation of meiosis involved in egg activation;GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16067-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25095-1", "uniprot_id": [ { "id": "AGTRA_RAT", "url": "https://www.uniprot.org/uniprot/P25095", "type": "external" } ], "mass": 40890.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor A", "gene_name": "Agtr1", "organism": "Rat", "refseq_name": "type-1 angiotensin II receptor A", "refseq_ac": [ { "id": "NP_112247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112247", "type": "external" } ], "gene_names_uniprotkb": "Agtr1; Agtr1a; At1a", "gene_names_refseq": "AT1A; AT1R; AT1; Agtr1a; Agtr1", "protein_names_uniprotkb": "Type-1 angiotensin II receptor A; AT1 receptor A; Angiotensin II type-1 receptor A", "protein_names_refseq": "AT1 receptor A; angiotensin II type-1 receptor A; angiotensin II type-1A receptor; angiotensin receptor 1a; type-1 angiotensin II receptor A; type-1A angiotensin II receptor; vascular type-1 angiotensin II receptor", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); atrial fibrillation (Disease Ontology:DOID:0060224); COVID-19 (Disease Ontology:DOID:0080600); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); nephritis (Disease Ontology:DOID:10952); sarcoidosis (Disease Ontology:DOID:11335); Friedreich ataxia (Disease Ontology:DOID:12705); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); Parkinson's disease (Disease Ontology:DOID:14330); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); hyperinsulinism (Disease Ontology:DOID:2018); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); placental insufficiency (Disease Ontology:DOID:3891); renal cell carcinoma (Disease Ontology:DOID:4450); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (rno:24180); (R-RNO-375276); (R-RNO-416476); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10191272;10218949;10747880;11579203;1533121;1544458;1599457;2041570;2043116;36868433;37355221;37501512;37667574;38160798;7713098;9814969", "class_list": "", "function": "Angiotensin II type 1a receptor knockout ameliorates high-fat diet-induced cardiac dysfunction by regulating glucose and lipid metabolism., [RefSeq, PubMed]; Astrocytic AT1R deficiency ameliorates Abeta-induced cognitive deficits and synaptotoxicity through beta-arrestin2 signaling., [RefSeq, PubMed]; DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development., [RefSeq, PubMed]; Fasting increases circulating angiotensin levels and brain Agtr1a expression in male rats., [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:10747880, PubMed:2041570). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:10747880)., [UniProtKB, PubMed, PubMed]; Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 3, "mined_n_glycosites": 3, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9QVS5", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0031711 bradykinin receptor binding;GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P25095-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28234-1", "uniprot_id": [ { "id": "CXA5_RAT", "url": "https://www.uniprot.org/uniprot/P28234", "type": "external" } ], "mass": 40233.0, "length": 356, "protein_name": "Gap junction alpha-5 protein", "gene_name": "Gja5", "organism": "Rat", "refseq_name": "gap junction alpha-5 protein", "refseq_ac": [ { "id": "NP_062153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062153", "type": "external" } ], "gene_names_uniprotkb": "Gja5; Cxn-40", "gene_names_refseq": "Cx40; Cxni; Gja5", "protein_names_uniprotkb": "Gap junction alpha-5 protein; Connexin-40; Cx40", "protein_names_refseq": "connexin 40; connexin i; gap junction alpha-5 protein; gap junction membrane channel protein alpha 5", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); overactive bladder syndrome (Disease Ontology:DOID:0070355); atrial standstill 1 (Disease Ontology:DOID:0080662); hypertension (Disease Ontology:DOID:10763); renovascular hypertension (Disease Ontology:DOID:1591); glomerulonephritis (Disease Ontology:DOID:2921); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:50563); (R-RNO-190861)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1328644;1370487;22673903;27304225;28157110;28457700;28870649;9403066", "class_list": "", "function": "Data are consistent with contributions of G2 and D3 residues to Cx40 channel pore structure, but not with postulated hydrophobic W4 intermolecular interactions; results indicate an absolute requirement for an amphipathic W3/4 residue; alternatively hypothesize that the connexin D2/3-W3/4 locus interacts with the highly conserved FIFR M1 motif to stabilize the NT domain within the pore, [RefSeq, PubMed]; Lipopolysaccharide impairs permeability of pulmonary microvascular endothelial cells via Connexin40/protein kinase C/nfkappaB pathway., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; The A96S, G38D, and P88S Cx40 mutations slow conduction and increased the propensity for inducible AF., [RefSeq, PubMed]; This study demonstrated the Cx40 was upregulated after traumatic brain injury in a linear correlated manner with increased oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0097718 disordered domain specific binding;GO:0055077 gap junction hemi-channel activity;GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling;GO:0086076 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0042995 cell projection;GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28234-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47196-1", "uniprot_id": [ { "id": "AKT1_RAT", "url": "https://www.uniprot.org/uniprot/P47196", "type": "external" } ], "mass": 55735.0, "length": 480, "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "Akt1", "organism": "Rat", "refseq_name": "RAC-alpha serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_150233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150233", "type": "external" } ], "gene_names_uniprotkb": "Akt1", "gene_names_refseq": "Akt1; Akt", "protein_names_uniprotkb": "RAC-alpha serine/threonine-protein kinase; 2.7.11.1; PKB alpha; PKB; Protein kinase B alpha; Protein kinase B; RAC-PK-alpha", "protein_names_refseq": "AKT1 kinase; PKB alpha; RAC protein kinase alpha RAC-PK alpha; RAC-PK-alpha; RAC-alpha serine/threonine-protein kinase; murine thymoma viral (v-akt) oncogene homolog 1; protein kinase B alpha; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Cowden syndrome 6 (Disease Ontology:DOID:0081002); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); esophageal carcinoma (Disease Ontology:DOID:1107); alcoholic hepatitis (Disease Ontology:DOID:12351); vulva cancer (Disease Ontology:DOID:1245); Proteus syndrome (Disease Ontology:DOID:13482); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); opiate dependence (Disease Ontology:DOID:2559); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); malignant astrocytoma (Disease Ontology:DOID:3069); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); esophageal cancer (Disease Ontology:DOID:5041); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); paraplegia (Disease Ontology:DOID:607); amphetamine abuse (Disease Ontology:DOID:670); hepatocellular carcinoma (Disease Ontology:DOID:684); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24185); (R-RNO-1257604); (R-RNO-1358803); (R-RNO-1474151); (R-RNO-165159); (R-RNO-165181); (R-RNO-198323); (R-RNO-198693); (R-RNO-199418); (R-RNO-203615); (R-RNO-211163); (R-RNO-354192); (R-RNO-3769402); (R-RNO-389357); (R-RNO-389513); (R-RNO-392451); (R-RNO-450385); (R-RNO-450604); (R-RNO-5218920); (R-RNO-5628897); (R-RNO-6804757); (R-RNO-6804758); (R-RNO-6804759); (R-RNO-6811558); (R-RNO-69202); (R-RNO-69656); (R-RNO-8849469); (R-RNO-8876198); (R-RNO-8948751); (R-RNO-9009391); (R-RNO-9604323); (R-RNO-9607240); (R-RNO-9614399); (R-RNO-9634638); (R-RNO-9755511); (R-RNO-9841251); (R-RNO-9856530)", "pathway_count": 37, "publication_count": 466, "publication_id_list": 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"class_list": "", "function": "AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:9228007, PubMed:11882383, PubMed:21432781, PubMed:21620960). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:21432781, PubMed:21620960). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:11882383, PubMed:21432781, PubMed:21620960). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (PubMed:10400692, PubMed:9632753). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (By similarity). AKT also regulates the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT also regulates cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Part of a positive feedback loop of mTORC2 signaling by mediating phosphorylation of MAPKAP1/SIN1, promoting mTORC2 activation (By similarity). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (By similarity). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (PubMed:12107176). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (PubMed:15546921). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor 1 (IGF1) (By similarity). AKT mediates the antiapoptotic effects of IGF1 (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53. Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility. Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation. Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (By similarity). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (By similarity). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (By similarity). Acts as a negative regulator of the cGAS-STING pathway by mediating phosphorylation of CGAS during mitosis, leading to its inhibition (By similarity). Acts as a regulator of mitochondrial calcium uptake by mediating phosphorylation of MICU1 in the mitochondrial intermembrane space, impairing MICU1 maturation (By similarity). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (By similarity). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]; MiR- 211 represses apoptosis of nerve cells in rats with cerebral infarction through PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-182 promotes apoptosis of neural cells in cerebral infarction rats by PI3K/AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal Stem Cells Enhance Myocardial Protection by Upregulating CD25[+] T Cells in Acute Myocardial Infarction Rat Model. Publication Status: Online-Only, [RefSeq, PubMed]; Synergistic effects of T-2 toxin and selenium deficiency exacerbate renal fibrosis through modulation of the ERalpha/PI3K/Akt signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 19, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 47, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1902018 negative regulation of cilium assembly;GO:0036294 cellular response to decreased oxygen levels;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0002430 complement receptor mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 46.9, "record_id": "P47196-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48037-1", "uniprot_id": [ { "id": "ANXA6_RAT", "url": "https://www.uniprot.org/uniprot/P48037", "type": "external" } ], "mass": 75754.0, "length": 673, "protein_name": "Annexin A6", "gene_name": "Anxa6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Anxa6; Anx6", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin A6; Annexin VI; Annexin-6; CBP 65/67; Calcium-binding protein 65/67", "protein_names_refseq": "", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "1618851;18683930;21454685;22673903;7607247", "class_list": "", "function": "May associate with CD21. May regulate the release of Ca(2+) from intracellular stores., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0034220 monoatomic ion transmembrane transport;GO:0097190 apoptotic signaling pathway;GO:0051560 mitochondrial calcium ion homeostasis;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P48037-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51635-1", "uniprot_id": [ { "id": "AK1A1_RAT", "url": "https://www.uniprot.org/uniprot/P51635", "type": "external" } ], "mass": 36506.0, "length": 325, "protein_name": "Aldo-keto reductase family 1 member A1", "gene_name": "Akr1a1", "organism": "Rat", "refseq_name": "aldo-keto reductase family 1 member A1", "refseq_ac": [ { "id": "NP_112262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112262", "type": "external" } ], "gene_names_uniprotkb": "Akr1a1; Alr", "gene_names_refseq": "Akr1a1; Akr1a4", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member A1; 1.1.1.19; 1.1.1.20; 1.1.1.2; 1.1.1.372; 1.1.1.54; 1.6.-.-; 3-DG-reducing enzyme; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Glucuronate reductase; Glucuronolactone reductase; S-nitroso-CoA reductase; ScorR", "protein_names_refseq": "3-DG-reducing enzyme; S-nitroso-CoA reductase; alcohol dehydrogenase; aldehyde reductase; aldo-keto reductase family 1 member A1; glucuronate reductase; glucuronolactone reductase; scorR", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:78959); (R-RNO-156590); (R-RNO-5661270)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "22673903;22820017;25152401;4463942;7827091;8500767", "class_list": "", "function": "Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids (PubMed:22820017, PubMed:25152401). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:22820017). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (PubMed:25152401, PubMed:8500767). Involved also in the detoxification of lipid-derived aldehydes like acrolein (PubMed:25152401). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 5, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0047939 L-glucuronate reductase activity;GO:0047956 glycerol dehydrogenase (NADP+) activity;GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity;GO:0047655 allyl-alcohol dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0043066 negative regulation of apoptotic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0046185 aldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51635-1", "record_type": "protein", "filter_code": "0000000.0010111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54645-1", "uniprot_id": [ { "id": "AAPK1_RAT", "url": "https://www.uniprot.org/uniprot/P54645", "type": "external" } ], "mass": 63973.0, "length": 559, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "Prkaa1", "organism": "Rat", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "refseq_ac": [ { "id": "NP_062015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062015", "type": "external" } ], "gene_names_uniprotkb": "Prkaa1; Ampk1", "gene_names_refseq": "AMPKalpha1; Prkaa1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-1; 2.7.11.1; 2.7.11.26; 2.7.11.31; ACACA kinase; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-1; ACACA kinase; AMPK alpha-1 chain; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); cholestasis (Disease Ontology:DOID:13580); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); lung non-small cell carcinoma (Disease Ontology:DOID:3908); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:65248); (R-RNO-1632852); (R-RNO-380972); (R-RNO-5628897); (R-RNO-6804756); (R-RNO-9931269)", "pathway_count": 6, "publication_count": 28, "publication_id_list": "10025949;10642499;11069105;11598104;11724780;12065600;12740371;12764152;14511394;14614828;14709557;16054095;16054096;17341212;17851531;21204788;21399626;21460634;22673903;2369897;32305957;33640872;36240643;37627248;7961907;8557660;8910387;9029219", "class_list": "", "function": "AMPKalpha1 Deficiency in Astrocytes from a Rat Model of ALS Is Associated with an Altered Metabolic Resilience. Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14511394). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (By similarity). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (By similarity). Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively (PubMed:2369897, PubMed:9029219). Promotes lipolysis of lipid droplets by mediating phosphorylation of isoform 1 of CHKA (CHKalpha2) (By similarity). Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3 (PubMed:11069105, PubMed:11598104, PubMed:12065600). AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160 (By similarity). Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A (PubMed:11724780, PubMed:12740371). Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm (By similarity). In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription (By similarity). Acts as a key regulator of cell growth and proliferation by phosphorylating FNIP1, TSC2, RPTOR, WDR24 and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2 (By similarity). Also phosphorylates and inhibits GATOR2 subunit WDR24 in response to nutrient limitation, leading to suppress glucose-mediated mTORC1 activation (By similarity). In response to energetic stress, phosphorylates FNIP1, inactivating the non-canonical mTORC1 signaling, thereby promoting nuclear translocation of TFEB and TFE3, and inducing transcription of lysosomal or autophagy genes (By similarity). In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1 (By similarity). In that process, it also activates WDR45/WIPI4. Phosphorylates CASP6, thereby preventing its autoprocessing and subsequent activation (By similarity). In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochondrial import (By similarity). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it (By similarity). May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it (By similarity). Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo (PubMed:21204788). Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1 (PubMed:10025949, PubMed:14709557, PubMed:17341212). Regulates hepatic lipogenesis. Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. Upon stress, regulates mitochondrial fragmentation through phosphorylation of MTFR1L (By similarity). Phosphorylates ALDH7A1 in response to cellular stress, such as hypoxia or ferroptotic stress, promoting ALDH7A1 recruitment to membranes (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSC-EXO) regulate autophagy through AMPK-ULK1 signaling pathway to ameliorate diabetic cardiomyopathy., [RefSeq, PubMed]; Melatonin improves mitochondrial biogenesis through the AMPK/PGC1alpha pathway to attenuate ischemia/reperfusion-induced myocardial damage., [RefSeq, PubMed]; Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0030424 axon", "go_biological_process": "GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904179 positive regulation of adipose tissue development;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "P54645-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59649-1", "uniprot_id": [ { "id": "FXYD7_RAT", "url": "https://www.uniprot.org/uniprot/P59649", "type": "external" } ], "mass": 8487.0, "length": 80, "protein_name": "FXYD domain-containing ion transport regulator 7", "gene_name": "Fxyd7", "organism": "Rat", "refseq_name": "FXYD domain-containing ion transport regulator 7", "refseq_ac": [ { "id": "NP_071291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071291", "type": "external" } ], "gene_names_uniprotkb": "Fxyd7", "gene_names_refseq": "Fxyd7", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 7", "protein_names_refseq": "FXYD domain-containing ion transport regulator 7", "tax_id": 10116, "disease": "", "pathway": " (rno:63848); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10950925;12093728;22535957;22673903", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (By similarity). Increases the apparent affinity for intracellular Na(+) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Expressed only in brain, rat FXYD7 is a type I membrane protein with N-terminal, post-translational Thr modifications, important for stability. FXYD7 is a tissue- and isoform-specific Na,K-ATPase regulator. It may play a role in neuronal excitability., [RefSeq, PubMed]; This reference sequence was derived from multiple ESTs and validated by similar mouse cDNA and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0005890 sodium:potassium-exchanging ATPase complex;GO:0016020 membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P59649-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62944-1", "uniprot_id": [ { "id": "AP2B1_RAT", "url": "https://www.uniprot.org/uniprot/P62944", "type": "external" } ], "mass": 104553.0, "length": 937, "protein_name": "AP-2 complex subunit beta", "gene_name": "Ap2b1", "organism": "Rat", "refseq_name": "AP-2 complex subunit beta", "refseq_ac": [ { "id": "NP_542150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542150", "type": "external" } ], "gene_names_uniprotkb": "Ap2b1; Clapb1", "gene_names_refseq": "Ap2b1", "protein_names_uniprotkb": "AP-2 complex subunit beta; AP105B; Adaptor protein complex AP-2 subunit beta; Adaptor-related protein complex 2 subunit beta; Beta-2-adaptin; Beta-adaptin; Clathrin assembly protein complex 2 beta large chain; Plasma membrane adaptor HA2/AP2 adaptin beta subunit", "protein_names_refseq": "AP-1 complex subunit beta-1-like; AP-2 complex subunit beta-like; AP-2 complex subunit beta; AP105B; adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; beta-2-adaptin; beta-adaptin; beta2-adaptin; clathrin assembly protein complex 2 beta large chain; plasma membrane adaptor HA2/AP2 adaptin beta subunit", "tax_id": 10116, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:140670); (R-RNO-177504); (R-RNO-2132295); (R-RNO-416993); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 11, "publication_count": 11, "publication_id_list": "14745134;15473838;18683930;19287005;1969413;22484487;22673903;2495531;34502162;38843836;7559550", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P21851", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030118 clathrin coat;GO:0045202 synapse;GO:0030122 AP-2 adaptor complex;GO:0030131 clathrin adaptor complex", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:0007507 heart development;GO:0001822 kidney development;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P62944-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97878-1", "uniprot_id": [ { "id": "EXOC5_RAT", "url": "https://www.uniprot.org/uniprot/P97878", "type": "external" } ], "mass": 81737.0, "length": 708, "protein_name": "Exocyst complex component 5", "gene_name": "Exoc5", "organism": "Rat", "refseq_name": "exocyst complex component 5", "refseq_ac": [ { "id": "NP_071540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071540", "type": "external" } ], "gene_names_uniprotkb": "Exoc5; Sec10l1", "gene_names_refseq": "Exoc5; Sec10l1", "protein_names_uniprotkb": "Exocyst complex component 5; 71 kDa component of rsec6/8 secretory complex; Exocyst complex component Sec10; p71", "protein_names_refseq": "71 kDa component of rsec6/8 secretory complex; SEC10-like 1; exocyst complex component 5; exocyst complex component Sec10; p71 component of rsec6/8 secretory complex", "tax_id": 10116, "disease": "obstructive nephropathy (Disease Ontology:DOID:0070314); bicuspid aortic valve disease (Disease Ontology:DOID:0080332)", "pathway": " (rno:60627); (R-RNO-264876); (R-RNO-5620916)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16641100;31593505;9073068;9405631", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]; Heterozygous knockout of Exoc5 in skeletal myoblast cells leads to impaired GLUT4 trafficking to the plasma membrane and hinders glucose uptake in response to an insulin stimulus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N5", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0030496 midbody;GO:0000145 exocyst;GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0072659 protein localization to plasma membrane;GO:0001822 kidney development;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97878-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05962-1", "uniprot_id": [ { "id": "ADT1_RAT", "url": "https://www.uniprot.org/uniprot/Q05962", "type": "external" } ], "mass": 32989.0, "length": 298, "protein_name": "ADP/ATP translocase 1", "gene_name": "Slc25a4", "organism": "Rat", "refseq_name": "ADP/ATP translocase 1", "refseq_ac": [ { "id": "NP_445967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445967", "type": "external" } ], "gene_names_uniprotkb": "Slc25a4; Aac1; Ant1", "gene_names_refseq": "Ant1; Slc25a4", "protein_names_uniprotkb": "ADP/ATP translocase 1; ADP,ATP carrier protein 1; ANT 1; Adenine nucleotide translocator 1; Solute carrier family 25 member 4", "protein_names_refseq": "ADP,ATP carrier protein 1; ADP/ATP translocase 1; ANT 1; adenine nucleotide translocator 1; adenine nucleotide translocator), member 4; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 12a (Disease Ontology:DOID:0080130); mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); Alzheimer's disease (Disease Ontology:DOID:10652); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); epilepsy (Disease Ontology:DOID:1826); mitochondrial myopathy (Disease Ontology:DOID:699); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:85333); (R-RNO-166187); (R-RNO-83936)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "16418269;18683930;22673903;26446791;26548633;26835787;27080394;27213235;30391711;31213526;34502162;38843836;8399300", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity) In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ANT1 overexpression compensates impaired adenine nucleotide translocase activity under oxygen-restricted conditions, [RefSeq, PubMed]; Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia, [RefSeq, PubMed]; Catalyzes the exchange of ADP and ATP across the membrane., [UniProtKB, UniProtKB]; Our data suggest that conformational changes of ANT may be directly involved in the opening of the Tl(+)-induced mitochondrial permeability transition pore in the inner membrane of Ca(2+)-loaded rat liver mitochondria, [RefSeq, PubMed]; Taken together, peroxynitrite produced during cardiac ischemia and reperfusion injury can nitrate tyrosine residues of two key mitochondrial membrane proteins involved in bioenergetics and energy transfer via binding to hexokinase 2 to contribute to mitochondrial and cellular dysfunction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0005471 ATP:ADP antiporter activity;GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0001889 liver development;GO:0007507 heart development;GO:0046902 regulation of mitochondrial membrane permeability;GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q05962-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PWT8-1", "uniprot_id": [ { "id": "AP4M1_RAT", "url": "https://www.uniprot.org/uniprot/Q2PWT8", "type": "external" } ], "mass": 49853.0, "length": 453, "protein_name": "AP-4 complex subunit mu-1", "gene_name": "Ap4m1", "organism": "Rat", "refseq_name": "AP-4 complex subunit mu-1 isoform 1", "refseq_ac": [ { "id": "NP_001033066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033066", "type": "external" } ], "gene_names_uniprotkb": "Ap4m1", "gene_names_refseq": "Ap4m1", "protein_names_uniprotkb": "AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; Mu4-adaptin; mu-ARP2; mu4", "protein_names_refseq": "AP-4 adapter complex mu subunit; AP-4 adaptor complex mu subunit; AP-4 complex subunit mu-1 isoform 1; AP-4 complex subunit mu-1; adapter-related protein complex 4 mu-1 subunit; adapter-related protein complex 4 subunit mu-1; adaptor-related protein complex 4, mu 1 subunit; adaptor-related protein complex AP-4, mu 1; mu subunit of AP-4; mu-ARP2; mu-adaptin-related protein 2; mu4-adaptin; mu4", "tax_id": 10116, "disease": "hereditary spastic paraplegia 50 (Disease Ontology:DOID:0110802)", "pathway": " (rno:304344); (R-RNO-432720)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14572453;24486887", "class_list": "", "function": "AP4M1 is not only down-regulated at both the mRNA and protein levels, but also redistributed from dendrites to axons in oxygen-glucose deprived hippocampal neurons., [RefSeq, PubMed]; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (By similarity). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (PubMed:14572453)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex;GO:0030124 AP-4 adaptor complex", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0008104 intracellular protein localization;GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2PWT8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3HS82-1", "uniprot_id": [ { "id": "AMTN_RAT", "url": "https://www.uniprot.org/uniprot/Q3HS82", "type": "external" } ], "mass": 22080.0, "length": 212, "protein_name": "Amelotin", "gene_name": "Amtn", "organism": "Rat", "refseq_name": "amelotin precursor", "refseq_ac": [ { "id": "NP_001037761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037761", "type": "external" } ], "gene_names_uniprotkb": "Amtn; EO-017", "gene_names_refseq": "Amtn", "protein_names_uniprotkb": "Amelotin", "protein_names_refseq": "amelotin precursor", "tax_id": 10116, "disease": "amelogenesis imperfecta type 3B (Disease Ontology:DOID:0080243)", "pathway": " (rno:689404); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16787391;17143547;21154245", "class_list": "", "function": "Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis., [UniProtKB, UniProtKB, PubMed]; ODAM and AMTN have a role at the cell-tooth interface, and that ODAM is likely also implicated in cellular events during formation and regeneration of the junctional epithelium. Publication Status: Online-Only, [RefSeq, PubMed]; The amino acid sequence of rat amelotin showed 62% identity with the sequence from humans. It was expressed considerably later than the other enamel proteins, suggesting that amelotin may serve a different function., [RefSeq, PubMed]; The isolation and characterization of amelotin at the expression and localization levels from the rat is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005911 cell-cell junction;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042475 odontogenesis of dentin-containing tooth;GO:0070166 enamel mineralization;GO:0070169 positive regulation of biomineral tissue development;GO:0070175 positive regulation of enamel mineralization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3HS82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56AP7-1", "uniprot_id": [ { "id": "CRBN_RAT", "url": "https://www.uniprot.org/uniprot/Q56AP7", "type": "external" } ], "mass": 50877.0, "length": 445, "protein_name": "Protein cereblon", "gene_name": "Crbn", "organism": "Rat", "refseq_name": "protein cereblon", "refseq_ac": [ { "id": "NP_001015003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015003", "type": "external" } ], "gene_names_uniprotkb": "Crbn", "gene_names_refseq": "Crbn", "protein_names_uniprotkb": "Protein cereblon", "protein_names_refseq": "protein cereblon", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); autosomal recessive intellectual developmental disorder 2 (Disease Ontology:DOID:0081178)", "pathway": " (rno:297498)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16045448;19166841;21232561;22673903;24755080;29393594;29730289", "class_list": "", "function": "Aerobic exercise training decreases cereblon level in the skeletal muscle of diabetic rats., [RefSeq, PubMed]; CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation., [RefSeq, PubMed]; CRBN may play an important role in assembly and surface expression of functional BK(Ca) channels by direct interaction with the cytosolic C-terminus of its alpha-subunit., [RefSeq, PubMed]; Crbn is expressed in the retina and binds to voltage-gated chloride channels., [RefSeq, PubMed]; In neonatal cardiomyocytes, overexpression of CRBN significantly reduced AMPK activity, as demonstrated by reductions in both phosphorylation levels of AMPK and the expression of its downstream target genes., [RefSeq, PubMed]; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L110;Q499S7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031334 positive regulation of protein-containing complex assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0031333 negative regulation of protein-containing complex assembly;GO:0034766 negative regulation of monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q56AP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJT1-1", "uniprot_id": [ { "id": "AN34A_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJT1", "type": "external" } ], "mass": 52456.0, "length": 495, "protein_name": "Ankyrin repeat domain-containing protein 34A", "gene_name": "Ankrd34a", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 34A", "refseq_ac": [ { "id": "NP_001020151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020151", "type": "external" } ], "gene_names_uniprotkb": "Ankrd34a", "gene_names_refseq": "Ankrd34a; Ankrd34; RGD1308412", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 34A", "protein_names_refseq": "ankyrin repeat domain 34; ankyrin repeat domain-containing protein 34A", "tax_id": 10116, "disease": "", "pathway": " (rno:295283)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJU7-1", "uniprot_id": [ { "id": "WASF1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJU7", "type": "external" } ], "mass": 61515.0, "length": 559, "protein_name": "Actin-binding protein WASF1", "gene_name": "Wasf1", "organism": "Rat", "refseq_name": "actin-binding protein WASF1 isoform 1", "refseq_ac": [ { "id": "NP_001020285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020285", "type": "external" } ], "gene_names_uniprotkb": "Wasf1; Wave1", "gene_names_refseq": "Wasf1", "protein_names_uniprotkb": "Actin-binding protein WASF1; Protein WAVE-1; WASP family protein member 1; Wiskott-Aldrich syndrome protein family member 1", "protein_names_refseq": "WAS protein family, member 1; WASP family 1; WASP family protein member 1; actin-binding protein WASF1 isoform 1; actin-binding protein WASF1; protein WAVE-1; wiskott-Aldrich syndrome protein family member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:294568); (R-RNO-2029482); (R-RNO-4420097); (R-RNO-5663213); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "16530190;16723544;17304222;18683930;19460862", "class_list": "", "function": "Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The WAVE1 G-protein regulatory (GPR) peptide inhibited GTPgammaS binding to purified G-protein.A WAVE1-G-protein complex was also observed following transfection of COS7 cells with Gialpha3 and WAVE1., [RefSeq, PubMed]; The control of actin polymerization and branching via moesin or WAVE1 is a key function of estrogen receptor alpha in neurons, which may be particularly relevant for the regulation of dendritic spines, [RefSeq, PubMed]; Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0016601 Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5BJU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7W6-1", "uniprot_id": [ { "id": "F234A_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7W6", "type": "external" } ], "mass": 60637.0, "length": 552, "protein_name": "Protein FAM234A", "gene_name": "Fam234a", "organism": "Rat", "refseq_name": "protein FAM234A", "refseq_ac": [ { "id": "NP_001009701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009701", "type": "external" } ], "gene_names_uniprotkb": "Fam234a; Itfg3", "gene_names_refseq": "Fam234a; Itfg3; RGD1311484", "protein_names_uniprotkb": "Protein FAM234A; Protein ITFG3", "protein_names_refseq": "integrin alpha FG-GAP repeat containing 3; protein FAM234A; protein ITFG3-like; protein ITFG3", "tax_id": 10116, "disease": "", "pathway": " (rno:360502)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M7W6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD51-1", "uniprot_id": [ { "id": "AKA12_RAT", "url": "https://www.uniprot.org/uniprot/Q5QD51", "type": "external" } ], "mass": 181110.0, "length": 1687, "protein_name": "A-kinase anchor protein 12", "gene_name": "Akap12", "organism": "Rat", "refseq_name": "A-kinase anchor protein 12 isoform beta", "refseq_ac": [ { "id": "NP_001028825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028825", "type": "external" } ], "gene_names_uniprotkb": "Akap12", "gene_names_refseq": "AKAP12A; AKAP12B; AKAP12G; Akap12", "protein_names_uniprotkb": "A-kinase anchor protein 12; AKAP-12", "protein_names_refseq": "A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A-kinase anchor protein 12 isoform beta; AKAP-12; SSeCKS, Gravin, AKAP250", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); colorectal carcinoma (Disease Ontology:DOID:0080199); sciatic neuropathy (Disease Ontology:DOID:11446); brain ischemia (Disease Ontology:DOID:2316); osteosarcoma (Disease Ontology:DOID:3347); liver cirrhosis (Disease Ontology:DOID:5082); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:83425); (R-RNO-9035034)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12083796;15496411;15923193;22673903;24623461;28281242;8626441", "class_list": "", "function": "A role in mitogen-induced cytoskeletal reorganization, [RefSeq, PubMed]; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)., [UniProtKB]; HSPA12B overexpression interacts with AKAP12 and downregulate TXNIP in diabetic rats following acute myocardial infarction., [RefSeq, PubMed]; SSeCKS play an important role in sciatic nerve fibers and neurons in spinal cord and dorsal root ganglion during inflammation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 50, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5QD49;Q5QD50;Q9Z1F7", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008179 adenylate cyclase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035733 hepatic stellate cell activation;GO:0007165 signal transduction;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q5QD51-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63053-1", "uniprot_id": [ { "id": "ARC_RAT", "url": "https://www.uniprot.org/uniprot/Q63053", "type": "external" } ], "mass": 45353.0, "length": 396, "protein_name": "Activity-regulated cytoskeleton-associated protein", "gene_name": "Arc", "organism": "Rat", "refseq_name": "activity-regulated cytoskeleton-associated protein", "refseq_ac": [ { "id": "NP_062234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062234", "type": "external" } ], "gene_names_uniprotkb": "Arc", "gene_names_refseq": "Arc; rg3.1", "protein_names_uniprotkb": "Activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; Activity-regulated gene 3.1 protein; Arg3.1", "protein_names_refseq": "ARC/ARG3.1; activity regulated cytoskeletal-associated protein; activity-regulated cytoskeleton-associated protein; activity-regulated gene 3.1 protein; arg3.1", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); anxiety disorder (Disease Ontology:DOID:2030); morphine dependence (Disease Ontology:DOID:2560); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:54323)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10570490;10818134;11226315;17088211;17088212;17088213;18614031;22579289;23791196;25864631;28736134;29328916;30028513;32861833;32991626;33843051;34648950;37820952;38623867;7777577;7857651;9808461", "class_list": "", "function": "Arc regulates brain damage and neuroinflammation via Sirt1 signaling following subarachnoid hemorrhage., [RefSeq, PubMed]; Changes in concentrations of NMDA receptor subunit GluN2B, Arc and syntaxin-1 in dorsal hippocampus Schaffer collateral synapses in a rat learned helplessness model of depression., [RefSeq, PubMed]; Enhanced expression of activity-regulated cytoskeleton-associated protein in the medial prefrontal cortex is involved in working memory performance., [RefSeq, PubMed]; Experience-dependent persistent Arc expression is reduced in the aged hippocampus., [RefSeq, PubMed]; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (PubMed:29328916). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (PubMed:29328916). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (PubMed:29328916). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory (PubMed:10818134, PubMed:17088211, PubMed:17088212, PubMed:17088213). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed:17088211, PubMed:17088212). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed:23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (PubMed:22579289). This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material (PubMed:29328916). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed:10818134). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62743", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0110077 vesicle-mediated intercellular transport;GO:0006897 endocytosis;GO:0007612 learning;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q63053-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63191-1", "uniprot_id": [ { "id": "AEGP_RAT", "url": "https://www.uniprot.org/uniprot/Q63191", "type": "external" } ], "mass": 133777.0, "length": 1216, "protein_name": "Apical endosomal glycoprotein", "gene_name": "Mamdc4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mamdc4; Aegp", "gene_names_refseq": "", "protein_names_uniprotkb": "Apical endosomal glycoprotein; MAM domain-containing protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:252882)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7829488", "class_list": "", "function": "Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:1990909 Wnt signalosome", "go_biological_process": "GO:0007399 nervous system development;GO:0015031 protein transport;GO:0016055 Wnt signaling pathway;GO:0034504 protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63191-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H54-1", "uniprot_id": [ { "id": "FHI1B_RAT", "url": "https://www.uniprot.org/uniprot/Q66H54", "type": "external" } ], "mass": 86272.0, "length": 791, "protein_name": "FHF complex subunit HOOK-interacting protein 1B", "gene_name": "Fhip1b", "organism": "Rat", "refseq_name": "FHF complex subunit HOOK-interacting protein 1B", "refseq_ac": [ { "id": "NP_001005538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005538", "type": "external" } ], "gene_names_uniprotkb": "Fhip1b; Fam160a2", "gene_names_refseq": "FHIP; Fam160a2; Fhip1b", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 1B; FHIP1B; FHIP; FTS- and Hook-interacting protein", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 1B; FTS and Hook-interacting protein; family with sequence similarity 160, member A2", "tax_id": 10116, "disease": "", "pathway": " (rno:293343)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070695 FHF complex", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FS4-1", "uniprot_id": [ { "id": "AMPL_RAT", "url": "https://www.uniprot.org/uniprot/Q68FS4", "type": "external" } ], "mass": 56150.0, "length": 519, "protein_name": "Cytosol aminopeptidase", "gene_name": "Lap3", "organism": "Rat", "refseq_name": "cytosol aminopeptidase", "refseq_ac": [ { "id": "NP_001011910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011910", "type": "external" } ], "gene_names_uniprotkb": "Lap3", "gene_names_refseq": "LAP-3; Lap3", "protein_names_uniprotkb": "Cytosol aminopeptidase; 3.4.11.1; 3.4.11.5; 3.4.13.23; Cysteinylglycine-S-conjugate dipeptidase; LAP-3; LAP; Leucine aminopeptidase 3; Leucyl aminopeptidase; Peptidase S; Proline aminopeptidase; Prolyl aminopeptidase", "protein_names_refseq": "LAP; cysteinylglycine-S-conjugate dipeptidase; cytosol aminopeptidase; leucyl aminopeptidase; peptidase S; proline aminopeptidase; prolyl aminopeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:289668)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12675513;22673903;28100784;34502162;35404840;6108111", "class_list": "", "function": "Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD., [RefSeq, PubMed]; Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides (PubMed:12675513, PubMed:6108111). The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (By similarity). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (By similarity). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status (PubMed:12675513)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.1", "type": "external" }, { "id": "3.4.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.5", "type": "external" }, { "id": "3.4.13.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.23", "type": "external" }, { "id": "3.4.13.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.18", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0004180 carboxypeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q68FS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4K7-1", "uniprot_id": [ { "id": "ABRA_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4K7", "type": "external" } ], "mass": 42901.0, "length": 375, "protein_name": "Actin-binding Rho-activating protein", "gene_name": "Abra", "organism": "Rat", "refseq_name": "actin-binding Rho-activating protein", "refseq_ac": [ { "id": "NP_787038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787038", "type": "external" } ], "gene_names_uniprotkb": "Abra; Ms1", "gene_names_refseq": "Abra; Ms1; Stars", "protein_names_uniprotkb": "Actin-binding Rho-activating protein; MS1; STARS; Striated muscle activator of Rho-dependent signaling", "protein_names_refseq": "actin-binding Rho-activating protein; striated muscle activator of Rho-dependent signaling", "tax_id": 10116, "disease": "", "pathway": " (rno:286965)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11983702;12067735;19686740;22081479;22673903;26656831;30210579", "class_list": "", "function": "Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling., [UniProtKB, UniProtKB]; In rat cardiomyocytes Ms1 is exclusively found in sarcomere. A nuclear localisation site in the N-terminus is required for nuclear localisation. Ms1 has the potential to act directly in the nucleus through specific interaction with DNA in development Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis., [RefSeq, PubMed]; The C-terminal half of the MS1 protein contains two independent F-actin binding domains., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BMV2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0030017 sarcomere;GO:0030016 myofibril", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0045893 positive regulation of DNA-templated transcription;GO:0035025 positive regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K4K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XV6-1", "uniprot_id": [ { "id": "FXYD6_RAT", "url": "https://www.uniprot.org/uniprot/Q91XV6", "type": "external" } ], "mass": 10388.0, "length": 94, "protein_name": "FXYD domain-containing ion transport regulator 6", "gene_name": "Fxyd6", "organism": "Rat", "refseq_name": "FXYD domain-containing ion transport regulator 6 precursor", "refseq_ac": [ { "id": "NP_071288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071288", "type": "external" } ], "gene_names_uniprotkb": "Fxyd6; Php", "gene_names_refseq": "Fxyd6; Php", "protein_names_uniprotkb": "FXYD domain-containing ion transport regulator 6; Phosphohippolin; VESP6; Vascular endothelial cell-specific protein 6", "protein_names_refseq": "FXYD domain-containing ion transport regulator 6 precursor; VESP6; phosphohippolin; vascular endothelial cell-specific protein 6", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:63847); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11165386;15193427;17209044;17676640;26479776", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:17209044). Decreases the apparent affinity of the transporter for Na(+) (PubMed:17209044). In addition to modulating NKA kinetics, may also function as a regulator of NKA localization to the plasma membrane (PubMed:17209044)., [UniProtKB, PubMed]; FXYD6 is expressed in the inner ear and may have a role in endolymph homeostasis and neuronal activity, [RefSeq, PubMed]; Findings suggest that Php may play an important role in the excitability of neurons in the central nervous system during postnatal development, as well as those in the adult brain, [RefSeq, PubMed]; This reference sequence was derived from multiple replicate ESTs and a deposited cDNA, and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD6, is novel and has not been characterized as a protein. The name 'phosphohippolin' has been used in GenBank, but there is no evidence yet of protein phosphorylation. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec 2000]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLR4", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane;GO:0043269 regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91XV6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99068-1", "uniprot_id": [ { "id": "AMRP_RAT", "url": "https://www.uniprot.org/uniprot/Q99068", "type": "external" } ], "mass": 42032.0, "length": 360, "protein_name": "Alpha-2-macroglobulin receptor-associated protein", "gene_name": "Lrpap1", "organism": "Rat", "refseq_name": "alpha-2-macroglobulin receptor-associated protein precursor", "refseq_ac": [ { "id": "NP_001162584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162584", "type": "external" } ], "gene_names_uniprotkb": "Lrpap1", "gene_names_refseq": "Lrpap1", "protein_names_uniprotkb": "Alpha-2-macroglobulin receptor-associated protein; Alpha-2-MRAP; Gp330-binding 45 kDa protein; Low density lipoprotein receptor-related protein-associated protein 1; RAP", "protein_names_refseq": "RAP; alpha-2-MRAP; alpha-2-macroglobulin receptor-associated protein precursor; alpha-2-macroglobulin receptor-associated protein; gp330-binding 45 kDa protein; low density lipoprotein receptor-related protein-associated protein 1", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); membranous glomerulonephritis (Disease Ontology:DOID:10976); myopia (Disease Ontology:DOID:11830); dementia (Disease Ontology:DOID:1307); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:116565)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1400426;1718973;21454685;22673903;2408041;29393594;7681839;8642311", "class_list": "", "function": "Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZX8;Q642A1;Q64723", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0048019 receptor antagonist activity;GO:0035473 lipase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002091 negative regulation of receptor internalization;GO:0010916 negative regulation of very-low-density lipoprotein particle clearance;GO:0048259 regulation of receptor-mediated endocytosis;GO:1900222 negative regulation of amyloid-beta clearance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99068-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESC1-1", "uniprot_id": [ { "id": "AGRL4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESC1", "type": "external" } ], "mass": 82451.0, "length": 738, "protein_name": "Adhesion G protein-coupled receptor L4", "gene_name": "Adgrl4", "organism": "Rat", "refseq_name": "adhesion G protein-coupled receptor L4 precursor", "refseq_ac": [ { "id": "NP_071630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071630", "type": "external" } ], "gene_names_uniprotkb": "Adgrl4; Eltd1; Etl", "gene_names_refseq": "Adgrl4; Eltd1; Etl", "protein_names_uniprotkb": "Adhesion G protein-coupled receptor L4; EGF,latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; ETL protein", "protein_names_refseq": "EGF, latrophilin and seven transmembrane domain containing 1; EGF, latrophilin and seven transmembrane domain-containing protein 1; EGF, latrophilin seven transmembrane domain containing 1; EGF-TM7-latrophilin-related protein; adhesion G protein-coupled receptor L4 precursor", "tax_id": 10116, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (rno:64124)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11050079", "class_list": "", "function": "Endothelial orphan receptor that acts as a key regulator of angiogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESC0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ESC1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHG3-1", "uniprot_id": [ { "id": "APJ_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHG3", "type": "external" } ], "mass": 42349.0, "length": 377, "protein_name": "Apelin receptor", "gene_name": "Aplnr", "organism": "Rat", "refseq_name": "apelin receptor", "refseq_ac": [ { "id": "NP_112639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112639", "type": "external" } ], "gene_names_uniprotkb": "Aplnr; Agtrl1; Apj", "gene_names_refseq": "Agtrl1; Apj; Aplnr", "protein_names_uniprotkb": "Apelin receptor; Angiotensin receptor-like 1; B78; G protein-coupled receptor APJ; GPCR34", "protein_names_refseq": "B78; G-protein coupled receptor APJ; GPCR34; angiotensin receptor-like 1; apelin receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:83518); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10777510;11004481;11146423;11359874;12603839;22810587;30582943;32223946;36878020;37245722;38959295", "class_list": "", "function": "ELABELA-APJ-Akt/YAP Signaling Axis: A Novel Mechanism of Aerobic Exercise in Cardioprotection of Myocardial Infarction Rats., [RefSeq, PubMed]; G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11359874). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor. APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy. However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4., [RefSeq, PubMed]; Organ specificity of APJ receptor mRNA and distribution of the APJ receptor in rat brain and spinal cord was determined, [RefSeq, PubMed]; The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats., [RefSeq, PubMed]; The effect of experimental varicocele on the apelin and APJ expressions in rat testis tissue., [RefSeq, PubMed]; The enhanced activity of endogenous apelin and APJ receptor in paraventricular nucleus contributes to sympathetic activation in hypertension., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESK2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding;GO:0060182 apelin receptor activity;GO:0140897 mechanoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0003171 atrioventricular valve development;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JHG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI93-1", "uniprot_id": [ { "id": "A4GAT_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI93", "type": "external" } ], "mass": 41551.0, "length": 360, "protein_name": "Lactosylceramide 4-alpha-galactosyltransferase", "gene_name": "A4galt", "organism": "Rat", "refseq_name": "lactosylceramide 4-alpha-galactosyltransferase", "refseq_ac": [ { "id": "NP_071576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071576", "type": "external" } ], "gene_names_uniprotkb": "A4galt", "gene_names_refseq": "A4galt; Gb3", "protein_names_uniprotkb": "Lactosylceramide 4-alpha-galactosyltransferase; 2.4.1.228; Alpha-1,4-N-acetylglucosaminyltransferase; Alpha-1,4-galactosyltransferase; Alpha4Gal-T1; Gb3 synthase; Globotriaosylceramide synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase", "protein_names_refseq": "Gb3 synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase; alpha 1,4-galactosyltransferase (P blood group); alpha-1,4-N-acetylglucosaminyltransferase; alpha4Gal-T1; globotriaosylceramide synthase; lactosylceramide 4-alpha-galactosyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:63888); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10854428", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as CD77 (PubMed:10854428). Globoside Gb3Cer/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer/CD77 regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR98", "ec_number_list": [ { "id": "2.4.1.228", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.228", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0015643 toxic substance binding;GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0001576 globoside biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0007009 plasma membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JI93-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIK1-1", "uniprot_id": [ { "id": "CDHR5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIK1", "type": "external" } ], "mass": 90976.0, "length": 862, "protein_name": "Cadherin-related family member 5", "gene_name": "Cdhr5", "organism": "Rat", "refseq_name": "cadherin-related family member 5 precursor", "refseq_ac": [ { "id": "NP_612534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612534", "type": "external" } ], "gene_names_uniprotkb": "Cdhr5; Mucdhl; Mupcdh", "gene_names_refseq": "Cdhr5; Mucdhl; Mupcdh", "protein_names_uniprotkb": "Cadherin-related family member 5; GP100; Mu-protocadherin", "protein_names_refseq": "GP100; cadherin-related family member 5 precursor; mu-protocadherin; mucin and cadherin like; mucin and cadherin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171554)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10801787;22673903", "class_list": "", "function": "Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 18, "predicted_n_glycosites": 9, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZY9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005905 clathrin-coated pit;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:1904970 brush border assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N1-1", "uniprot_id": [ { "id": "F16P2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1N1", "type": "external" } ], "mass": 36887.0, "length": 339, "protein_name": "Fructose-1,6-bisphosphatase isozyme 2", "gene_name": "Fbp2", "organism": "Rat", "refseq_name": "fructose-1,6-bisphosphatase isozyme 2", "refseq_ac": [ { "id": "NP_446168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446168", "type": "external" } ], "gene_names_uniprotkb": "Fbp2", "gene_names_refseq": "FBPase; Fbp2", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase isozyme 2; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; Muscle FBPase", "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; muscle FBPase", "tax_id": 10116, "disease": "", "pathway": " (rno:114508); (R-RNO-70263)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15498578;16814784;21046014;22021109;22673903;29507044", "class_list": "", "function": "Ca2+ appears to be a strong inhibitor of muscle FBPase, [RefSeq, PubMed]; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate., [UniProtKB]; Insulin and not hyperglycemia plays a crucial role in the nuclear accumulation of FBPase in vivo., [RefSeq, PubMed]; Overexpression of FBP2 significantly increased insulin-stimulated glucose uptake in tibialis of chow animals (control 14.3 +/- 1.7; FBP2 17.6 +/- 1.6 micromol/min/100 g) and High fat diet animals (control 9.6 +/- 1.1; FBP2 11.2 +/- 1.1micromol/min/100 g)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.11", "type": "external" } ], "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030018 Z disc;GO:0070161 anchoring junction", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z1N1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20650-1", "uniprot_id": [ { "id": "PPM1A_RAT", "url": "https://www.uniprot.org/uniprot/P20650", "type": "external" } ], "mass": 42417.0, "length": 382, "protein_name": "Protein phosphatase 1A", "gene_name": "Ppm1a", "organism": "Rat", "refseq_name": "protein phosphatase 1A", "refseq_ac": [ { "id": "NP_058734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058734", "type": "external" } ], "gene_names_uniprotkb": "Ppm1a; Pp2c1; Pppm1a", "gene_names_refseq": "Pp2c1; Ppm1a", "protein_names_uniprotkb": "Protein phosphatase 1A; 3.1.3.16; PP2C-alpha; Protein phosphatase 2C isoform alpha; Protein phosphatase IA", "protein_names_refseq": "IA; PP2C-alpha; protein phosphatase 1A; protein phosphatase IA", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cardiomyopathy (Disease Ontology:DOID:0050700); cardiac arrest (Disease Ontology:DOID:0060319); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24666); (R-RNO-2173795); (R-RNO-380972)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22384250;22673903;22926646;2538815", "class_list": "", "function": "Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3. This recruitment promoted the dephosphorylation of pSmad3 and attenuated the pSmad3-dependent production of TGF-beta1., [RefSeq, PubMed]; Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in the differentiation and survival processes of nerve cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0044325 transmembrane transporter binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0046827 positive regulation of protein export from nucleus;GO:0045893 positive regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35244-1", "uniprot_id": [ { "id": "PRDX6_RAT", "url": "https://www.uniprot.org/uniprot/O35244", "type": "external" } ], "mass": 24819.0, "length": 224, "protein_name": "Peroxiredoxin-6", "gene_name": "Prdx6", "organism": "Rat", "refseq_name": "peroxiredoxin-6", "refseq_ac": [ { "id": "NP_446028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446028", "type": "external" } ], "gene_names_uniprotkb": "Prdx6; Aipla2; Aop2; Tsa", "gene_names_refseq": "LPCAT-5; Prdx6", "protein_names_uniprotkb": "Peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 1.11.1.27; 2.3.1.23; 3.1.1.4; Acidic calcium-independent phospholipase A2; Antioxidant protein 2; Glutathione-dependent peroxiredoxin; LPC acyltransferase 5; LPCAT-5; Lyso-PC acyltransferase 5; Lysophosphatidylcholine acyltransferase 5; NSGPx; Non-selenium glutathione peroxidase; Thiol-specific antioxidant protein; aiPLA2", "protein_names_refseq": "1-Cys PRX; 1-Cys peroxiredoxin; LPC acyltransferase 5; NSGPx; acidic calcium-independent phospholipase A2; aiPLA2; antioxidant protein 2; glutathione-dependent peroxiredoxin; lyso-PC acyltransferase 5; lysophosphatidylcholine acyltransferase 5; non-selenium glutathione peroxidase; peroxiredoxin-6; thiol-specific antioxidant protein", "tax_id": 10116, "disease": "", "pathway": " (rno:94167); (R-RNO-3299685); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "15004285;17652308;19140803;19700648;26830860;34482185;34502162;34863856;36209344;36401357;38530594;8999971", "class_list": "", "function": "Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy., [RefSeq, PubMed]; PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha Activation in Rats Fed High-Fat Diet., [RefSeq, PubMed]; PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation., [RefSeq, PubMed]; PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15004285). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:15004285, PubMed:17652308, PubMed:8999971). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0004623 phospholipase A2 activity;GO:0051920 peroxiredoxin activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006979 response to oxidative stress;GO:0046475 glycerophospholipid catabolic process;GO:0000302 response to reactive oxygen species;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O35244-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35458-1", "uniprot_id": [ { "id": "VIAAT_RAT", "url": "https://www.uniprot.org/uniprot/O35458", "type": "external" } ], "mass": 57407.0, "length": 525, "protein_name": "Vesicular inhibitory amino acid transporter", "gene_name": "Slc32a1", "organism": "Rat", "refseq_name": "vesicular inhibitory amino acid transporter", "refseq_ac": [ { "id": "NP_113970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113970", "type": "external" } ], "gene_names_uniprotkb": "Slc32a1; Vgat; Viaat", "gene_names_refseq": "RUNC-47; Slc32a1; Vgat; Viaat", "protein_names_uniprotkb": "Vesicular inhibitory amino acid transporter; GABA and glycine transporter; RUNC-47; Solute carrier family 32 member 1; Vesicular GABA transporter; rGVAT; rat UNC-47 homolog", "protein_names_refseq": "GABA and glycine transporter; UNC-47 homolog; rGVAT; solute carrier family 32 (GABA vesicular transporter), member 1; vesicular GABA transporter; vesicular inhibitory amino acid transporter-like; vesicular inhibitory amino acid transporter", "tax_id": 10116, "disease": "generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:83612); (R-RNO-442660); (R-RNO-888590)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10036231;12031963;19052203;19843525;22673903;23919636;25749864;9349821;9822734", "class_list": "", "function": "Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals (By similarity) (PubMed:9349821). The transport is equally dependent on the chemical and electrical components of the proton gradient (PubMed:9349821). May also transport beta-alanine (PubMed:23919636). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Cortical axon terminals co-expressing VGLUT1 and VGAT can evoke simultaneously monosynaptic glutamate and gamma-aminobutyric acid responses., [RefSeq, PubMed]; VIAAT is expressed in rat islets and is more abundant in the mantle, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0015185 gamma-aminobutyric acid transmembrane transporter activity;GO:0140799 glycine:proton antiporter activity;GO:0140800 gamma-aminobutyric acid:proton antiporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0051286 cell tip;GO:0009986 cell surface;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0015816 glycine transport;GO:0021766 hippocampus development;GO:0015812 gamma-aminobutyric acid transport;GO:0051939 gamma-aminobutyric acid import;GO:0098700 neurotransmitter loading into synaptic vesicle", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35458-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14270-5", "uniprot_id": [ { "id": "PDE4D_RAT", "url": "https://www.uniprot.org/uniprot/P14270", "type": "external" } ], "mass": 90552.0, "length": 803, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4D", "gene_name": "Pde4d", "organism": "Rat", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4D isoform 1", "refseq_ac": [ { "id": "NP_001106799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106799", "type": "external" } ], "gene_names_uniprotkb": "Pde4d", "gene_names_refseq": "DPDE3; PDE3/IVd; Pde4d", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4D; 3.1.4.53; DPDE3; cAMP-specific phosphodiesterase 4D", "protein_names_refseq": "3',5'-cyclic AMP phosphodiesterase; 3',5'-cyclic-AMP phosphodiesterase 4D isoform 1; 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); acrodysostosis (Disease Ontology:DOID:14669); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083)", "pathway": " (rno:24627); (R-RNO-180024); (R-RNO-418555); (R-RNO-9860927)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10187850;11134006;11285255;12834813;15717866;17244609;17261351;22673903;2546153;2554303;30628641;32212953;37673361;38453769;7958996;8034568;8276818", "class_list": "", "function": "Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase., [RefSeq, PubMed]; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes., [UniProtKB]; Overexpression of Pde4d in rat granulosa cells inhibits maturation and atresia of antral follicles to induce polycystic ovary., [RefSeq, PubMed]; Targeting Aquaporin-5 by Phosphodiesterase 4 Inhibition Offers New Therapeutic Opportunities for Ovarian Ischemia Reperfusion Injury in Rats., [RefSeq, PubMed]; The mRNA expression of PDE4D was significantly increased in allergic rats, but PDE4B was not. PDE4B was mainly distributed in the cytoplasm, whereas PDE4D was mainly distributed in the cell membrane, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1E347;A1EC59;F1M1H7;O35470;Q6TRI0;Q8CG04;Q8CG06", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0032754 positive regulation of interleukin-5 production;GO:0061028 establishment of endothelial barrier;GO:1901898 negative regulation of relaxation of cardiac muscle;GO:0001934 positive regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P14270-5", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGU4-1", "uniprot_id": [ { "id": "AGAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGU4", "type": "external" } ], "mass": 124438.0, "length": 1186, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "gene_name": "Agap2", "organism": "Rat", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "refseq_ac": [ { "id": "NP_075415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075415", "type": "external" } ], "gene_names_uniprotkb": "Agap2; Centg1", "gene_names_refseq": "Agap2; Centg1; Pike", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; AGAP-2; Centaurin-gamma-1; Cnt-g1; PIKE; Phosphatidylinositol 3-kinase enhancer", "protein_names_refseq": "AGAP-2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; cnt-g1; nuclear GTPase PIKE; phosphatidylinositol 3-kinase enhancer", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:65218)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "11136977;11823862;14528310;15385964;15598747;16263930;21847098;22673903;24056044;24449917;29393594;38843836", "class_list": "", "function": "GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PIKE is a critical factor in controlling synaptic AMPA receptor insertion. Publication Status: Online-Only, [RefSeq, PubMed]; PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation., [RefSeq, PubMed]; RACK1 scaffolds AGAP2 to FAK to regulate FAK activity and cell adhesion during the differentiation process., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHW8", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:2000010 positive regulation of protein localization to cell surface;GO:0045860 positive regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8CGU4-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88846-1", "uniprot_id": [ { "id": "RNF4_RAT", "url": "https://www.uniprot.org/uniprot/O88846", "type": "external" } ], "mass": 21897.0, "length": 194, "protein_name": "E3 ubiquitin-protein ligase RNF4", "gene_name": "Rnf4", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF4", "refseq_ac": [ { "id": "NP_062055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062055", "type": "external" } ], "gene_names_uniprotkb": "Rnf4; Snurf", "gene_names_refseq": "Rnf4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF4; 2.3.2.27; Protein SNURF; RING finger protein 4; Small nuclear ring finger protein", "protein_names_refseq": "E3 ubiquitin ligase RNF4; E3 ubiquitin-protein ligase RNF4; RING-type E3 ubiquitin transferase RNF4; SNURF; small nuclear ring finger protein", "tax_id": 10116, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); Fanconi anemia complementation group B (Disease Ontology:DOID:0111098); Angelman syndrome (Disease Ontology:DOID:1932); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520)", "pathway": " (rno:29274); (R-RNO-983168)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11319220;14987998;15707587;18408734;20681948;20943951;22673903;22842904;26148049;9710597", "class_list": "", "function": "Crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin, [RefSeq, PubMed]; Data suggest that ubiquitin-conjugating enzyme E2 variant 2 (Ube2V2) and ring finger protein 4 (RNF4) together induce an active conformation of the ubiquitin-conjugating enzyme Ubc13-ubiquitin (Ubc13~Ub) thioester., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation (PubMed:14987998, PubMed:15707587, PubMed:18408734). Regulates the degradation of several proteins including PML and the transcriptional activator PEA3 (PubMed:15707587, PubMed:20943951). Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation (By similarity). Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 (By similarity). Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation (PubMed:11319220, PubMed:9710597). Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071394 cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88846-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22002-1", "uniprot_id": [ { "id": "CAC1C_RAT", "url": "https://www.uniprot.org/uniprot/P22002", "type": "external" } ], "mass": 243482.0, "length": 2169, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1C", "gene_name": "Cacna1c", "organism": "Rat", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1C", "refseq_ac": [ { "id": "NP_036649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036649", "type": "external" } ], "gene_names_uniprotkb": "Cacna1c; Cach2; Cacn2; Cacnl1a1; Cchl1a1", "gene_names_refseq": "Cacna1c; RATIVS302", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; RBC; Rat brain class C; Voltage-gated calcium channel subunit alpha Cav1.2", "protein_names_refseq": "L-type calcium channel alpha-1 subunit; RBC; brain class C; calcium channel, voltage-dependent, L type, alpha 1C subunit; calcium channel, voltage-dependent, alpha 1C subunit; voltage-dependent L-type calcium channel subunit alpha-1C; voltage-gated calcium channel subunit alpha Cav1.2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); Timothy syndrome (Disease Ontology:DOID:0060173); neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures (Disease Ontology:DOID:0070536); Brugada syndrome 3 (Disease Ontology:DOID:0110220); long QT syndrome 8 (Disease Ontology:DOID:0110649); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:24239); (R-RNO-422356); (R-RNO-5576892); (R-RNO-5576893)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "1311102;15140941;15170217;1648941;1692134;2170396;22673903;24751537;36724867;36995425;37372947;38602101;39409130;7479909;7485440;8396138;9278523", "class_list": "", "function": "Arterial Smooth Muscle Cell AKAP150 Mediates Exercise-Induced Repression of CaV1.2 Channel Function in Cerebral Arteries of Hypertensive Rats., [RefSeq, PubMed]; Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Characterisation of the neural basis underlying appetitive extinction & renewal in Cacna1c rats. Review article, [RefSeq, PubMed]; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rapid Pacing Decreases L-type Ca[2+] Current and Alters Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular Myocytes., [RefSeq, PubMed]; Thyroid Hormone Upregulates Cav1.2 Channels in Cardiac Cells via the Downregulation of the Channels' beta4 Subunit. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P27733;P27734;Q62816;Q63271;Q64178", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density", "go_biological_process": "GO:0097305 response to alcohol;GO:0006939 smooth muscle contraction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007507 heart development;GO:0008542 visual learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P22002-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84092-1", "uniprot_id": [ { "id": "AP2M1_RAT", "url": "https://www.uniprot.org/uniprot/P84092", "type": "external" } ], "mass": 49655.0, "length": 435, "protein_name": "AP-2 complex subunit mu", "gene_name": "Ap2m1", "organism": "Rat", "refseq_name": "AP-2 complex subunit mu", "refseq_ac": [ { "id": "NP_446289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446289", "type": "external" } ], "gene_names_uniprotkb": "Ap2m1", "gene_names_refseq": "Ap2m1; Ap50; Clapm1; mu2", "protein_names_uniprotkb": "AP-2 complex subunit mu; AP-2 mu chain; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; Mu2-adaptin; Plasma membrane adaptor AP-2 50 kDa protein", "protein_names_refseq": "AP-2 complex subunit mu; AP-2 mu chain; adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; adaptor protein complex AP-2 subunit mu; adaptor-related protein complex 2 subunit mu; adaptor-related protein complex 2, mu 1 subunit; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; coat assembly protein complex 50 kD; mu2-adaptin; plasma membrane adaptor AP-2 50 kDa protein", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 60 with seizures (Disease Ontology:DOID:0061050); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:116563); (R-RNO-177504); (R-RNO-190873); (R-RNO-196025); (R-RNO-2132295); (R-RNO-416993); (R-RNO-437239); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8866427); (R-RNO-8964038)", "pathway_count": 13, "publication_count": 16, "publication_id_list": "10228163;11247301;11516654;12086608;12121421;14745134;15473838;15985462;19140243;20947020;25061211;28139716;3148444;35486718;38843836;9812899", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2) (PubMed:14745134, PubMed:15473838). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways (PubMed:14745134, PubMed:15473838). Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation (PubMed:14745134, PubMed:15473838). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome (PubMed:14745134, PubMed:15473838). The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components (PubMed:14745134, PubMed:15473838). Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation (PubMed:14745134, PubMed:15473838). AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis (PubMed:14745134, PubMed:15473838). AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface (By similarity). AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules (PubMed:15985462). AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway (By similarity). During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 mu (AP2M1) subunit binds to transmembrane cargo proteins; it recognizes the Y-X-X-Phi motifs (PubMed:15985462). The surface region interacting with to the Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible through a conformational change following phosphorylation of AP-2 mu subunit at Thr-156 in membrane-associated AP-2 (PubMed:11516654, PubMed:15985462). The membrane-specific phosphorylation event appears to involve assembled clathrin which activates the AP-2 mu kinase AAK1 (By similarity). Plays a role in endocytosis of frizzled family members upon Wnt signaling (PubMed:20947020)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules., [UniProtKB, UniProtKB, UniProtKB]; Our data reveal that AP-2 has important roles in functional axogenesis by proper extension of axon as well as the formation of AIS during the early step of neurodevelopment. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20172;P53679", "ec_number_list": [], "go_molecular_function": "GO:0050750 low-density lipoprotein particle receptor binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding;GO:0005048 signal sequence binding;GO:0097718 disordered domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0043195 terminal bouton", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006886 intracellular protein transport;GO:0031623 receptor internalization;GO:1903077 negative regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P84092-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAF6-1", "uniprot_id": [ { "id": "ATPK_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAF6", "type": "external" } ], "mass": 10452.0, "length": 88, "protein_name": "ATP synthase F(0) complex subunit f, mitochondrial", "gene_name": "Atp5mf; Zfp394", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit f, mitochondrial", "refseq_ac": [ { "id": "NP_001258046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258046", "type": "external" } ], "gene_names_uniprotkb": "Atp5mf; Zfp394; Atp5j2; Atp5mf", "gene_names_refseq": "Atp5j2; Atp5mf", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase membrane subunit f", "protein_names_refseq": "ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase subunit f, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2", "tax_id": 10116, "disease": "", "pathway": " (rno:252860); (rno:690441); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17575325;22673903;29393594;38843836", "class_list": "", "function": "Subunit f, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0005634 nucleus;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:1902600 proton transmembrane transport;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006754 ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "D3ZAF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15999-1", "uniprot_id": [ { "id": "ATPA_RAT", "url": "https://www.uniprot.org/uniprot/P15999", "type": "external" } ], "mass": 59754.0, "length": 553, "protein_name": "ATP synthase F(1) complex subunit alpha, mitochondrial", "gene_name": "Atp5f1a", "organism": "Rat", "refseq_name": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_075581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075581", "type": "external" } ], "gene_names_uniprotkb": "Atp5f1a; Atp5a1", "gene_names_refseq": "Atp5a1; Atp5f1a", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase F1 subunit alpha", "protein_names_refseq": "ATP synthase F(1) complex subunit alpha, mitochondrial precursor; ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; mitochondrial H+-ATP synthase alpha subunit", "tax_id": 10116, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 4A (Disease Ontology:DOID:0070461); mitochondrial complex V (ATP synthase) deficiency nuclear type 4B (Disease Ontology:DOID:0070462); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); combined oxidative phosphorylation deficiency 22 (Disease Ontology:DOID:0111498); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:65262); (R-RNO-163210); (R-RNO-8949613); (R-RNO-9837999)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "17575325;18683930;19423663;2137825;21926988;22673903;24098488;26446791;26769832;27213235;31511561;34502162;34894202;38843836;9736690", "class_list": "", "function": "Chronic stress inhibits testosterone synthesis in Leydig cells through mitochondrial damage via Atp5a1. Erratum:[J Cell Mol Med. 2023 Oct;27(20):3213-3214. doi: 10.1111/jcmm.17829. PMID: 37724039], [RefSeq, PubMed]; Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase, [RefSeq, PubMed]; Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB, UniProtKB]; Subunit alpha, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the catalytic subunit beta (ATP5F1B), forms the catalytic core in the F(1) domain. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 22, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 22, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 22, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 21, "binding_glycan_count": 0, "secondary_ac_list": "Q6P753", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding;GO:0043532 angiostatin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0045471 response to ethanol;GO:0006754 ATP biosynthetic process;GO:0001937 negative regulation of endothelial cell proliferation;GO:0071549 cellular response to dexamethasone stimulus", "synthesized_glycan_count": 0, "hit_score": 3.9, "record_id": "P15999-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09626-1", "uniprot_id": [ { "id": "ATP4A_RAT", "url": "https://www.uniprot.org/uniprot/P09626", "type": "external" } ], "mass": 114038.0, "length": 1033, "protein_name": "Potassium-transporting ATPase alpha chain 1", "gene_name": "Atp4a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Atp4a; Hka", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium-transporting ATPase alpha chain 1; 7.2.2.19; Gastric H(+)/K(+) ATPase subunit alpha; Proton pump", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); stomach cancer (Disease Ontology:DOID:10534); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (rno:24216); (R-RNO-936837)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1849840;20921224;22448261;22673903;3023364;7840253", "class_list": "", "function": "The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells (PubMed:20921224, PubMed:22448261). Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (PubMed:20921224, PubMed:22448261). Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1 (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state (By similarity) (PubMed:20921224, PubMed:22448261)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70511;P97892;Q63253;Q6LD86", "ec_number_list": [ { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" }, { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030955 potassium ion binding;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0005889 potassium:proton exchanging ATPase complex", "go_biological_process": "GO:0010155 regulation of proton transport;GO:0006883 intracellular sodium ion homeostasis;GO:0001696 gastric acid secretion;GO:0009410 response to xenobiotic stimulus;GO:0030007 intracellular potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09626-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07174-1", "uniprot_id": [ { "id": "TNR16_RAT", "url": "https://www.uniprot.org/uniprot/P07174", "type": "external" } ], "mass": 45433.0, "length": 425, "protein_name": "Tumor necrosis factor receptor superfamily member 16", "gene_name": "Ngfr", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 16 precursor", "refseq_ac": [ { "id": "NP_036742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036742", "type": "external" } ], "gene_names_uniprotkb": "Ngfr; Tnfrsf16", "gene_names_refseq": "LNGFR; Ngfr; RNNGFRR; Tnfrsf16; p75NTR; p75", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD", "protein_names_refseq": "NGF receptor; gp80-LNGFR; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor p75NGFR; low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; p75 ICD; tumor necrosis factor receptor superfamily member 16 precursor; tumor necrosis factor receptor superfamily member 16", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); diabetic encephalopathy (Disease Ontology:DOID:0050850); chronic pancreatitis (Disease Ontology:DOID:0051065); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); Lewy body dementia (Disease Ontology:DOID:12217); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); degenerative disc disease (Disease Ontology:DOID:90); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:24596); (R-RNO-193634); (R-RNO-193692); (R-RNO-205017); (R-RNO-205025); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-209563)", "pathway_count": 9, "publication_count": 23, "publication_id_list": "10514511;10985348;11150334;12095158;1446821;15131306;15378608;16498402;18596692;20036257;20716910;22155786;24908487;27056327;27457814;29393594;3027580;37036720;37334743;38423239;38504358;9305641;9927421", "class_list": "", "function": "Disentangling the signaling complexity of nerve growth factor receptors by CRISPR/Cas9., [RefSeq, PubMed]; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4 (PubMed:15131306, PubMed:18596692, PubMed:3027580). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:22155786, PubMed:24908487). In response to proNGF binding, the heterodimeric receptor with SORCS2 activates a signaling cascade that leads to decreased Rac activity, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells (PubMed:10514511, PubMed:10985348, PubMed:24908487). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Oligodendrocyte progenitor development from the postnatal rat subventricular zone is regulated by the p75 neurotrophin receptor., [RefSeq, PubMed]; Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats. Publication Status: Online-Only, [RefSeq, PubMed]; The expression of ProBDNF and its high affinity receptor P75NTR in the neurons of emotion-related brain regions of post-stroke depression rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0043121 neurotrophin binding;GO:0005516 calmodulin binding;GO:0015026 coreceptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0042488 positive regulation of odontogenesis of dentin-containing tooth;GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P07174-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04694-1", "uniprot_id": [ { "id": "ATTY_RAT", "url": "https://www.uniprot.org/uniprot/P04694", "type": "external" } ], "mass": 50635.0, "length": 454, "protein_name": "Tyrosine aminotransferase", "gene_name": "Tat", "organism": "Rat", "refseq_name": "tyrosine aminotransferase", "refseq_ac": [ { "id": "NP_036800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036800", "type": "external" } ], "gene_names_uniprotkb": "Tat", "gene_names_refseq": "Tat", "protein_names_uniprotkb": "Tyrosine aminotransferase; 2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase; TAT", "protein_names_refseq": "L-tyrosine:2-oxoglutarate aminotransferase; tyrosine aminotransferase", "tax_id": 10116, "disease": "tyrosinemia type II (Disease Ontology:DOID:0050725); tyrosinemia (Disease Ontology:DOID:9275)", "pathway": " (rno:24813); (R-RNO-8963684)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1682164;17170234;1983704;2562840;2863382;2901862", "class_list": "", "function": "Tat activity in skeletal muscle and liver was determined 24h after the last psychological stress and immobilization stress., [RefSeq, PubMed]; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB6", "ec_number_list": [ { "id": "2.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0004838 L-tyrosine-2-oxoglutarate transaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0006536 glutamate metabolic process;GO:0006979 response to oxidative stress;GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04694-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14925-1", "uniprot_id": [ { "id": "AMD_RAT", "url": "https://www.uniprot.org/uniprot/P14925", "type": "external" } ], "mass": 108675.0, "length": 976, "protein_name": "Peptidylglycine alpha-amidating monooxygenase", "gene_name": "Pam", "organism": "Rat", "refseq_name": "peptidylglycine alpha-amidating monooxygenase precursor", "refseq_ac": [ { "id": "NP_037132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037132", "type": "external" } ], "gene_names_uniprotkb": "Pam", "gene_names_refseq": "PHM; Pam", "protein_names_uniprotkb": "Peptidylglycine alpha-amidating monooxygenase; PAL; PAM; Peptidylamidoglycolate lyase", "protein_names_refseq": "basic salivary proline-rich protein 4-like; peptidyl-glycine alpha-amidating monooxygenase; peptidylglycine alpha-amidating monooxygenase precursor", "tax_id": 10116, "disease": "hypothyroidism (Disease Ontology:DOID:1459); prostate adenocarcinoma (Disease Ontology:DOID:2526); uveal melanoma (Disease Ontology:DOID:6039)", "pathway": " (rno:25508)", "pathway_count": 1, "publication_count": 25, "publication_id_list": "10079066;10504734;11931341;12369828;1448112;15131304;16100265;1740449;19604476;1988445;20958070;2211657;22673903;23247335;2337358;2401356;24627494;26170456;2911604;30271955;34061983;36880254;7680192;7893699;9837933", "class_list": "", "function": "Bifunctional enzyme that catalyzes amidation of the C-terminus of proteins (PubMed:10079066, PubMed:36880254, PubMed:7893699). Alpha-amidation is present at the C-terminus of many endocrine hormones and neuropeptides and is required for their activity (By similarity). C-terminal amidation also takes place in response to protein fragmentation triggered by oxidative stress, promoting degradation of amidated protein fragments by the proteasome (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme (PubMed:10079066). The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:10079066). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:10079066). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (PubMed:10079066)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Data indicate that H3A mutation eliminates the ability of internalized peptidylglycine alpha-amidating monooxygenase PAM-1 to return to secretory granules., [RefSeq, PubMed]; Disruption of AP-1-dependent late endosomal trafficking diminishes the ability of PAM to retain copper and produce amidated peptides., [RefSeq, PubMed]; Multiple roles for peptidylglycine alpha-amidating monooxygenase in the response to hypoxia., [RefSeq, PubMed]; The crystal structure of the oxidized form of PHM complexed with hydrogen peroxide., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70710;Q64616;Q64668", "ec_number_list": [ { "id": "1.14.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.17.3", "type": "external" }, { "id": "4.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0010043 response to zinc ion;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P14925-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48442-1", "uniprot_id": [ { "id": "CASR_RAT", "url": "https://www.uniprot.org/uniprot/P48442", "type": "external" } ], "mass": 120868.0, "length": 1079, "protein_name": "Extracellular calcium-sensing receptor", "gene_name": "Casr", "organism": "Rat", "refseq_name": "extracellular calcium-sensing receptor precursor", "refseq_ac": [ { "id": "NP_001296567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296567", "type": "external" } ], "gene_names_uniprotkb": "Casr; Gprc2a; Pcar1", "gene_names_refseq": "Casr; PCaR1; RaKCaR", "protein_names_uniprotkb": "Extracellular calcium-sensing receptor; CaSR; PCaR1; Parathyroid cell calcium-sensing receptor; RaKCaR", "protein_names_refseq": "Calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); extracellular calcium-sensing receptor precursor; extracellular calcium-sensing receptor; parathyroid Cell calcium-sensing receptor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); familial hypocalciuric hypercalcemia 1 (Disease Ontology:DOID:0060700); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia 1 (Disease Ontology:DOID:0090107); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); Charcot-Marie-Tooth disease recessive intermediate D (Disease Ontology:DOID:0110203); intellectual disability (Disease Ontology:DOID:1059); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hypercalcemia (Disease Ontology:DOID:12678); hyperparathyroidism (Disease Ontology:DOID:13543); atherosclerosis (Disease Ontology:DOID:1936); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:24247); (R-RNO-416476); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "17623778;17673178;22886306;33416112;33647324;35477244;38167726;38281732;7724534;7816802", "class_list": "", "function": "Astragaloside IV attenuates cerebral ischemiareperfusion injury in rats through the inhibition of calciumsensing receptormediated apoptosis., [RefSeq, PubMed]; Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility., [RefSeq, PubMed]; Decreased monocyte calcium sensing receptor expression in patients with chronic kidney disease is associated with impaired monocyte ability to reduce vascular calcification., [RefSeq, PubMed]; G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:22886306, PubMed:7816802). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (PubMed:22886306). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G proteins depending on the context. In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity. The G protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation. Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (By similarity). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats., [RefSeq, PubMed]; Stimulation of the calcium-sensing receptor induces relaxations of rat mesenteric arteries by endothelium-dependent and -independent pathways via BKCa and KATP channels., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0002931 response to ischemia;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48442-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61023-1", "uniprot_id": [ { "id": "CHP1_RAT", "url": "https://www.uniprot.org/uniprot/P61023", "type": "external" } ], "mass": 22432.0, "length": 195, "protein_name": "Calcineurin B homologous protein 1", "gene_name": "Chp1", "organism": "Rat", "refseq_name": "calcineurin B homologous protein 1", "refseq_ac": [ { "id": "NP_077053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077053", "type": "external" } ], "gene_names_uniprotkb": "Chp1; Chp", "gene_names_refseq": "Chp1; Chp; Wrch2", "protein_names_uniprotkb": "Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22", "protein_names_refseq": "EF-hand Ca2+-binding protein p22; EF-hand calcium-binding domain-containing protein p22; calcineurin B homologous protein 1; calcineurin B-like protein; calcineurin homologous protein; calcium-binding protein CHP; calcium-binding protein p22", "tax_id": 10116, "disease": "spastic ataxia (Disease Ontology:DOID:0050952)", "pathway": " (rno:64152); (R-RNO-2160916)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10512881;11481038;12204119;12966074;14657246;14769882;15312048;15987692;16511110;20720019;21543739;8626580", "class_list": "", "function": "Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62877", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0008017 microtubule binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity;GO:0061024 membrane organization;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P61023-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKI0-1", "uniprot_id": [ { "id": "WDR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKI0", "type": "external" } ], "mass": 66181.0, "length": 606, "protein_name": "WD repeat-containing protein 1", "gene_name": "Wdr1", "organism": "Rat", "refseq_name": "WD repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001014157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014157", "type": "external" } ], "gene_names_uniprotkb": "Wdr1", "gene_names_refseq": "Wdr1", "protein_names_uniprotkb": "WD repeat-containing protein 1", "protein_names_refseq": "WD repeat protein 1; WD repeat-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360950); (R-RNO-114608)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15337274;18683930;22821633", "class_list": "", "function": "Elevated WDR1 expression after acoustic overstimulation in the current experiments may provide a mechanism for protection against noise exposure., [RefSeq, PubMed]; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton;GO:0030054 cell junction", "go_biological_process": "GO:0043297 apical junction assembly;GO:0042247 establishment of planar polarity of follicular epithelium;GO:0030834 regulation of actin filament depolymerization;GO:0002446 neutrophil mediated immunity;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RKI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK4-1", "uniprot_id": [ { "id": "B2L14_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK4", "type": "external" } ], "mass": 36891.0, "length": 326, "protein_name": "Apoptosis facilitator Bcl-2-like protein 14", "gene_name": "Bcl2l14", "organism": "Rat", "refseq_name": "apoptosis facilitator Bcl-2-like protein 14", "refseq_ac": [ { "id": "NP_001019509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019509", "type": "external" } ], "gene_names_uniprotkb": "Bcl2l14", "gene_names_refseq": "Bcl2l14", "protein_names_uniprotkb": "Apoptosis facilitator Bcl-2-like protein 14; Bcl2-L-14", "protein_names_refseq": "Bcl2-like 14 (apoptosis facilitator); apoptosis facilitator Bcl-2-like protein 14; bcl2-L-14", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286)", "pathway": " (rno:500348)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in apoptosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHW5-1", "uniprot_id": [ { "id": "VAMP7_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHW5", "type": "external" } ], "mass": 24776.0, "length": 220, "protein_name": "Vesicle-associated membrane protein 7", "gene_name": "Vamp7", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 7", "refseq_ac": [ { "id": "NP_445983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445983", "type": "external" } ], "gene_names_uniprotkb": "Vamp7; Sybl1", "gene_names_refseq": "Sybl1; Vamp7", "protein_names_uniprotkb": "Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1; VAMP-7", "protein_names_refseq": "VAMP-7; synaptobrevin-like 1; synaptobrevin-like protein 1; vesicle-associated membrane protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:85491); (R-RNO-199992); (R-RNO-432720); (R-RNO-432722); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9020591)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "10459012;10559389;10777677;14993220;15133481;16495485;24210904;9553086", "class_list": "", "function": "Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The specificity of Reelin action on spontaneous neurotransmitter release requires VAMP7, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0043312 neutrophil degranulation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0008333 endosome to lysosome transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JHW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35152-1", "uniprot_id": [ { "id": "BET1L_RAT", "url": "https://www.uniprot.org/uniprot/O35152", "type": "external" } ], "mass": 12417.0, "length": 111, "protein_name": "BET1-like protein", "gene_name": "Bet1l", "organism": "Rat", "refseq_name": "BET1-like protein", "refseq_ac": [ { "id": "NP_062241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062241", "type": "external" } ], "gene_names_uniprotkb": "Bet1l; Gs15", "gene_names_refseq": "Bet1l; Bet1; Gs15", "protein_names_uniprotkb": "BET1-like protein; GOS-15; GS15; Golgi SNARE with a size of 15 kDa; Vesicle transport protein GOS15", "protein_names_refseq": "BET1-like protein; GOS-15; Golgi soluble N-ethylmaleimide-sensitive factor attachment protein 15; blocked early in transport 1 homolog like; golgi SNARE with a size of 15 kDa; golgi SNARE, 15 kD; vesicle transport protein GOS15", "tax_id": 10116, "disease": "uterine fibroid (Disease Ontology:DOID:13223); endometrial adenocarcinoma (Disease Ontology:DOID:2870)", "pathway": " (rno:54400); (R-RNO-6807878); (R-RNO-6811438)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12388752;14742712;9242691", "class_list": "", "function": "Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport., [RefSeq, PubMed]; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCU6", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005798 Golgi-associated vesicle;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:2000156 regulation of retrograde vesicle-mediated transport, Golgi to ER", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4T4-1", "uniprot_id": [ { "id": "FLIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4T4", "type": "external" } ], "mass": 137753.0, "length": 1212, "protein_name": "Filamin-A-interacting protein 1", "gene_name": "Filip1", "organism": "Rat", "refseq_name": "filamin-A-interacting protein 1", "refseq_ac": [ { "id": "NP_663715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663715", "type": "external" } ], "gene_names_uniprotkb": "Filip1", "gene_names_refseq": "Filip1; Filip", "protein_names_uniprotkb": "Filamin-A-interacting protein 1; FILIP", "protein_names_refseq": "filamin-A-interacting protein 1; filamin-interacting protein L-Filip; filamin-interacting protein S-Filip", "tax_id": 10116, "disease": "", "pathway": " (rno:246776)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12055638;15509752;15794127;22673903", "class_list": "", "function": "By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of Filamin A., [UniProtKB, PubMed, PubMed]; FILIP interacts with Filamin A, an indispensable actin-binding protein that is required for cell motility (filamin A), [RefSeq, PubMed]; Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JZS5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0015629 actin cytoskeleton;GO:0098794 postsynapse;GO:0001725 stress fiber", "go_biological_process": "GO:1903119 protein localization to actin cytoskeleton;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0022038 corpus callosum development;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K4T4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63331-1", "uniprot_id": [ { "id": "PP2AA_RAT", "url": "https://www.uniprot.org/uniprot/P63331", "type": "external" } ], "mass": 35608.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "Cdkl3; Ppp2ca", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1", "refseq_ac": [ { "id": "NP_058735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058735", "type": "external" } ], "gene_names_uniprotkb": "Cdkl3; Ppp2ca; Cdkl3", "gene_names_refseq": "PP2A; Pp2a1; Ppp2ca", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; 3.1.3.16; PP2A-alpha", "protein_names_refseq": "PP2A-alpha; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase-2A-alpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); meningioma (Disease Ontology:DOID:3565); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24672); (R-RNO-113501); (R-RNO-1295596); (R-RNO-141430); (R-RNO-141444); (R-RNO-180024); (R-RNO-195253); (R-RNO-196299); (R-RNO-198753); (R-RNO-202670); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2995383); (R-RNO-389356); (R-RNO-389513); (R-RNO-432142); (R-RNO-4641262); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-5675221); (R-RNO-6804757); (R-RNO-6811558); (R-RNO-68877); (R-RNO-69231); (R-RNO-69273); (R-RNO-9648025); (R-RNO-975957); (R-RNO-9833482); (R-RNO-9860927)", "pathway_count": 29, "publication_count": 7, "publication_id_list": "22673903;2461222;2554255;31974600;35043508;36555780;37722489", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate various proteins, such as AXIN1, p53/TP53, PIM3, WEE1. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3 (By similarity). Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). Catalyzes dephosphorylation of PIM3, promoting PIM3 ubiquitination and proteasomal degradation. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex. The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum stress induces liver cells apoptosis after brain death by suppressing the phosphorylation of protein phosphatase 2A., [RefSeq, PubMed]; HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway., [RefSeq, PubMed]; Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88591;P13353", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0031698 beta-2 adrenergic receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0003231 cardiac ventricle development;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P63331-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82808-1", "uniprot_id": [ { "id": "GFPT1_RAT", "url": "https://www.uniprot.org/uniprot/P82808", "type": "external" } ], "mass": 76827.0, "length": 681, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "gene_name": "Gfpt1", "organism": "Rat", "refseq_name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1", "refseq_ac": [ { "id": "NP_001005879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005879", "type": "external" } ], "gene_names_uniprotkb": "Gfpt1", "gene_names_refseq": "GFAT1m; GFAT1; GFAT; GFA; Gfpt1; Gfpt", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; 2.6.1.16; D-fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Glutamine:fructose-6-phosphate amidotransferase 1; Hexosephosphate aminotransferase 1", "protein_names_refseq": "D-fructose-6-phosphate amidotransferase 1; GFAT 1; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine:fructose-6-phosphate amidotransferase 1; hexosephosphate aminotransferase 1", "tax_id": 10116, "disease": "congenital myasthenic syndrome 12 (Disease Ontology:DOID:0110660); familial hyperlipidemia (Disease Ontology:DOID:1168); Machado-Joseph disease (Disease Ontology:DOID:1440); hyperinsulinism (Disease Ontology:DOID:2018); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:297417); (R-RNO-446210)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10898949;20506529;22673903;34735873", "class_list": "", "function": "Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not GFAT2., [RefSeq, PubMed]; Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:10898949). Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling (By similarity). Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest that cultured podocytes possess limited ability to synthesize glucosamine (GlcN) internally and therefore may need to receive GlcN from the extracellular environment., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XI08", "ec_number_list": [ { "id": "2.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.16", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0016597 amino acid binding;GO:0030246 carbohydrate binding;GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:0006042 glucosamine biosynthetic process;GO:0032869 cellular response to insulin stimulus;GO:0032868 response to insulin;GO:0006487 protein N-linked glycosylation;GO:0009744 response to sucrose", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P82808-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H234-1", "uniprot_id": [ { "id": "FLRT3_RAT", "url": "https://www.uniprot.org/uniprot/B1H234", "type": "external" } ], "mass": 72911.0, "length": 649, "protein_name": "Leucine-rich repeat transmembrane protein FLRT3", "gene_name": "Flrt3", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane protein FLRT3 precursor", "refseq_ac": [ { "id": "NP_001119763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119763", "type": "external" } ], "gene_names_uniprotkb": "Flrt3", "gene_names_refseq": "Flrt3; RGD1566005", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT3; Fibronectin-like domain-containing leucine-rich transmembrane protein 3", "protein_names_refseq": "fibronectin-like domain-containing leucine-rich transmembrane protein 3; leucine-rich repeat transmembrane protein FLRT3 precursor; leucine-rich repeat transmembrane protein FLRT3", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 21 with or without anosmia (Disease Ontology:DOID:0090093)", "pathway": " (rno:366205); (R-RNO-5654687)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14706654;15485775;22405201;31346030;38843836", "class_list": "", "function": "Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (By similarity). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (By similarity). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length (PubMed:15485775). Plays a role in the regulation of the density of glutamaergic synapses (PubMed:22405201). Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Study concludes that FLRT3 codes for a putative cell surface receptor implicated in both the development of the nervous system and in the regeneration of the peripheral nervous system., [RefSeq, PubMed]; These findings suggest that FLRT3 is produced by injured DRG neurons and increases neuronal excitability in the dorsal horn, leading to pain sensitization. Neuropathic pain induction is a novel function of FLRT3., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0032584 growth cone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007507 heart development;GO:0031175 neuron projection development;GO:0098609 cell-cell adhesion;GO:0007416 synapse assembly;GO:0048598 embryonic morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B1H234-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47819-1", "uniprot_id": [ { "id": "GFAP_RAT", "url": "https://www.uniprot.org/uniprot/P47819", "type": "external" } ], "mass": 49957.0, "length": 430, "protein_name": "Glial fibrillary acidic protein", "gene_name": "Gfap", "organism": "Rat", "refseq_name": "glial fibrillary acidic protein", "refseq_ac": [ { "id": "NP_058705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058705", "type": "external" } ], "gene_names_uniprotkb": "Gfap", "gene_names_refseq": "Gfap", "protein_names_uniprotkb": "Glial fibrillary acidic protein; GFAP", "protein_names_refseq": "glial fibrillary acidic protein alpha; glial fibrillary acidic protein delta; glial fibrillary acidic protein; intermediate filament", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); COVID-19 (Disease Ontology:DOID:0080600); alcohol use disorder (Disease Ontology:DOID:1574); Alexander disease (Disease Ontology:DOID:4252); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:24387)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10336251;12837269;1629938;17203480;2153890;22673903;32910393;34065959;35913387;37796476;38843836;7897704", "class_list": "", "function": "Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex-specific manner., [RefSeq, PubMed]; Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of Nestin and Glial Fibrillary Acidic Protein in the Marginal Ischemic Zone of the Brain in SHR Rats., [RefSeq, PubMed]; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells., [UniProtKB, UniProtKB, UniProtKB]; Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7REI0;Q7TQ31;Q9R1Q3;Q9Z2S0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0097449 astrocyte projection;GO:0005764 lysosome", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0060252 positive regulation of glial cell proliferation;GO:0006886 intracellular protein transport;GO:0030198 extracellular matrix organization;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P47819-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23576-1", "uniprot_id": [ { "id": "GBRA2_RAT", "url": "https://www.uniprot.org/uniprot/P23576", "type": "external" } ], "mass": 51182.0, "length": 451, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-2", "gene_name": "Gabra2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gabra2; Gabra-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor subunit alpha-2; GABAAR subunit alpha-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental and epileptic encephalopathy 78 (Disease Ontology:DOID:0112214); autistic disorder (Disease Ontology:DOID:12849); alcohol use disorder (Disease Ontology:DOID:1574); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:289606); (R-RNO-977443)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1849552;24090084;25172774;38843836", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 12, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0008503 benzodiazepine receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P23576-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70244-1", "uniprot_id": [ { "id": "CUBN_RAT", "url": "https://www.uniprot.org/uniprot/O70244", "type": "external" } ], "mass": 398987.0, "length": 3623, "protein_name": "Cubilin", "gene_name": "Cubn", "organism": "Rat", "refseq_name": "cubilin precursor", "refseq_ac": [ { "id": "NP_445784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445784", "type": "external" } ], "gene_names_uniprotkb": "Cubn; Ifcr", "gene_names_refseq": "Cubn; GP280; IFCR; MGA1", "protein_names_uniprotkb": "Cubilin; 460 kDa receptor; Glycoprotein 280; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; gp280", "protein_names_refseq": "460 kDa receptor; cubilin precursor; glycoprotein 280; intrinsic factor-cobalamin receptor; intrinsic factor-vitamin B12 receptor", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); coronary artery disease (Disease Ontology:DOID:3393); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:80848); (R-RNO-196791); (R-RNO-8964011); (R-RNO-9758881)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10400683;10811843;11805171;12724130;14576052;15616221;16641100;20237569;29402915;33510115;9153271;9478979;9691015", "class_list": "", "function": "Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Upregulation of Megalin, Cubilin, NGAL mRNA expression in kidney may represent tubular injury and apoptosis in chronic condition of rat diabetic model., [RefSeq, PubMed]", "predicted_glycosites": 39, "predicted_n_glycosites": 38, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 43, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030492 hemoglobin binding;GO:0031419 cobalamin binding", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007584 response to nutrient;GO:0008203 cholesterol metabolic process;GO:0042953 lipoprotein transport;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O70244-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000000000001000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23562-1", "uniprot_id": [ { "id": "B3AT_RAT", "url": "https://www.uniprot.org/uniprot/P23562", "type": "external" } ], "mass": 103173.0, "length": 927, "protein_name": "Band 3 anion transport protein", "gene_name": "Slc4a1", "organism": "Rat", "refseq_name": "band 3 anion transport protein", "refseq_ac": [ { "id": "NP_036783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036783", "type": "external" } ], "gene_names_uniprotkb": "Slc4a1; Ae1", "gene_names_refseq": "Slc4a1", "protein_names_uniprotkb": "Band 3 anion transport protein; AE 1; Anion exchange protein 1; Anion exchanger 1; Solute carrier family 4 member 1", "protein_names_refseq": "AE 1; Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3); anion exchange protein 1; anion exchanger 1; band 3 anion transport protein; solute carrier family 4 (anion exchanger), member 1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); metabolic acidosis (Disease Ontology:DOID:0050758); hereditary spherocytosis type 4 (Disease Ontology:DOID:0110919); iron deficiency anemia (Disease Ontology:DOID:11758); malaria (Disease Ontology:DOID:12365); hereditary spherocytosis (Disease Ontology:DOID:12971); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); hereditary elliptocytosis (Disease Ontology:DOID:2373); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); congenital hemolytic anemia (Disease Ontology:DOID:589)", "pathway": " (rno:24779); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-425381)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "21454685;22673903;24289085;2722777;8456965", "class_list": "", "function": "Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the structure and function of erythrocyte band 3., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0030492 hemoglobin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0014704 intercalated disc", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate;GO:0055085 transmembrane transport;GO:0072659 protein localization to plasma membrane;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23562-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07314-1", "uniprot_id": [ { "id": "GGT1_RAT", "url": "https://www.uniprot.org/uniprot/P07314", "type": "external" } ], "mass": 61610.0, "length": 568, "protein_name": "Glutathione hydrolase 1 proenzyme", "gene_name": "Ggt1", "organism": "Rat", "refseq_name": "glutathione hydrolase 1 proenzyme precursor", "refseq_ac": [ { "id": "NP_446292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446292", "type": "external" } ], "gene_names_uniprotkb": "Ggt1; Ggt", "gene_names_refseq": "GGLUT; Ggt1; Ggtp; Ggt", "protein_names_uniprotkb": "Glutathione hydrolase 1 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; GGT 1; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; Leukotriene-C4 hydrolase", "protein_names_refseq": "GGT 1; gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltranspeptidase 1; glutathione hydrolase 1 proenzyme precursor; glutathione hydrolase 1 proenzyme; leukotriene-C4 hydrolase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); gamma-glutamyl transpeptidase deficiency (Disease Ontology:DOID:0111257); gestational diabetes (Disease Ontology:DOID:11714); biliary atresia (Disease Ontology:DOID:13608); melanoma (Disease Ontology:DOID:1909); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:116568); (R-RNO-174403); (R-RNO-2142691); (R-RNO-5423646); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10392451;1671556;24090084;2567622;2573604;27525410;2869471;2869484;2896486;2907498;6122208;6136502;6142889;7910821;8776", "class_list": "", "function": "An extensive ductular reaction in advanced Hepatocellular carcinoma (HCC) and a strong correlation between PCK7 and levels of gammaGT and the poor prognosis and aggressiveness of HCC, is reported., [RefSeq, PubMed]; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (By similarity) (PubMed:6122208). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:6122208). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:6122208). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (PubMed:6122208)., [UniProtKB, PubMed, UniProtKB]; Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 4, "disease_count": 14, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q63217;Q63218;Q6AZ32", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0000048 peptidyltransferase activity;GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0016755 aminoacyltransferase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031982 vesicle;GO:0016020 membrane", "go_biological_process": "GO:0061017 hepatoblast differentiation;GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0097305 response to alcohol;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P07314-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70239-1", "uniprot_id": [ { "id": "AXIN1_RAT", "url": "https://www.uniprot.org/uniprot/O70239", "type": "external" } ], "mass": 92285.0, "length": 827, "protein_name": "Axin-1", "gene_name": "Axin1", "organism": "Rat", "refseq_name": "axin-1", "refseq_ac": [ { "id": "NP_077381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077381", "type": "external" } ], "gene_names_uniprotkb": "Axin1; Axin", "gene_names_refseq": "Axin1; Axin; axin-1", "protein_names_uniprotkb": "Axin-1; Axis inhibition protein 1; rAxin", "protein_names_refseq": "GSK-3beta interacting protein rAxin; axin-1; axis inhibition protein 1; rAxin", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:79257); (R-RNO-195253); (R-RNO-196299); (R-RNO-201681); (R-RNO-4641257); (R-RNO-4641262); (R-RNO-5689880)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "16815997;33582657;34495485;36464067;9482734", "class_list": "", "function": "Axin1 participates in blood-brain barrier protection during experimental ischemic stroke via phosphorylation at Thr485 in rats., [RefSeq, PubMed]; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (By similarity). Also facilitates the phosphorylation of APC by GSK3B (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Activates the AMP-activated protein kinase (AMPK) in response to calorie restriction by acting as a molecular adapter: recruited to late endosome membrane by the V-ATPase complex downstream of TULP3, and mediates association between STK11 and its AMPK substrates PRKAA1 and/or PRKAA2, leading to AMPK activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-3574 ameliorates intermittent hypoxia-induced cardiomyocyte injury through inhibiting Axin1., [RefSeq, PubMed]; MicroRNAs sequencing of plasma exosomes derived from patients with atrial fibrillation: miR-124-3p promotes cardiac fibroblast activation and proliferation by regulating AXIN1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0001934 positive regulation of protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0010629 negative regulation of gene expression;GO:0046330 positive regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70239-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08050-1", "uniprot_id": [ { "id": "CXA1_RAT", "url": "https://www.uniprot.org/uniprot/P08050", "type": "external" } ], "mass": 43031.0, "length": 382, "protein_name": "Gap junction alpha-1 protein", "gene_name": "Gja1", "organism": "Rat", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "NP_036699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036699", "type": "external" } ], "gene_names_uniprotkb": "Gja1; Cxn-43", "gene_names_refseq": "Cx43; Cxnk1; Gja1", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein", "protein_names_refseq": "connexin 43; connexin k1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); erythrokeratodermia variabilis (Disease Ontology:DOID:0050467); alcohol dependence (Disease Ontology:DOID:0050741); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); atrial fibrillation (Disease Ontology:DOID:0060224); oculodentodigital dysplasia (Disease Ontology:DOID:0060291); overactive bladder syndrome (Disease Ontology:DOID:0070355); erythrokeratodermia variabilis et progressiva 3 (Disease Ontology:DOID:0080249); autosomal recessive craniometaphyseal dysplasia (Disease Ontology:DOID:0080802); Parkinsonism (Disease Ontology:DOID:0080855); palmoplantar keratoderma and congenital alopecia 1 (Disease Ontology:DOID:0111244); syndactyly type 3 (Disease Ontology:DOID:0111817); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); urethral obstruction (Disease Ontology:DOID:12577); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); renovascular hypertension (Disease Ontology:DOID:1591); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); morphine dependence (Disease Ontology:DOID:2560); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); palmoplantar keratosis (Disease Ontology:DOID:3390); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); autoimmune thyroiditis (Disease Ontology:DOID:7188); myocarditis (Disease Ontology:DOID:820); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:24392); (R-RNO-190840); (R-RNO-190861); (R-RNO-190873); (R-RNO-191650); (R-RNO-196025); (R-RNO-9013406)", "pathway_count": 7, "publication_count": 60, "publication_id_list": "10085299;10871288;11124251;12011467;12270943;12417300;12874275;1371548;15181016;15213231;15250540;15350848;15492000;16000550;16474210;1651718;1652440;16613776;16678851;17513490;17612968;18408134;1852114;18629610;18636092;18789391;19423616;19781809;20127391;21148408;21617128;22549838;22608771;22673903;22737133;23058053;23747752;23834776;23922949;23973256;24500718;2472402;24780378;25115184;25159820;25225338;25625661;2826492;29664174;2987225;29959233;30740090;31114002;31374823;32580481;38583020;38599061;38653383;38967483;39049648", "class_list": "", "function": "Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis., [RefSeq, PubMed]; MiR-23b-3p Improves Brain Damage after Status Epilepticus by Reducing the Formation of Pathological High-Frequency Oscillations via Inhibition of cx43 in Rat Hippocampus., [RefSeq, PubMed]; NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity., [RefSeq, PubMed]; Role of connexin 43 in a rat model of periodontitis-induced renal injury., [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (PubMed:12011467). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in the conductive system of ventricular myocardium and heart morphogenesis (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; [Inhibition of connexin 43-mediated hemichannel activity promotes odontoblast differentiation of human dental pulp cells induced by lipopolysaccharide]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZE1", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0005102 signaling receptor binding;GO:0017124 SH3 domain binding;GO:0019904 protein domain specific binding;GO:0015267 channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0045836 positive regulation of meiotic nuclear division;GO:2000648 positive regulation of stem cell proliferation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 6.1, "record_id": "P08050-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16573-1", "uniprot_id": [ { "id": "CEAM1_RAT", "url": "https://www.uniprot.org/uniprot/P16573", "type": "external" } ], "mass": 57410.0, "length": 519, "protein_name": "Cell adhesion molecule CEACAM1", "gene_name": "Ceacam1", "organism": "Rat", "refseq_name": "cell adhesion molecule CEACAM1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001029032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029032", "type": "external" } ], "gene_names_uniprotkb": "Ceacam1", "gene_names_refseq": "BGPR; Bgp; CD66a; Ccam1; Ceacam1", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM1; ATP-dependent taurocolate-carrier protein; C-CAM 105; CEA cell adhesion molecule 1; Carcinoembryonic antigen-related cell adhesion molecule 1; Cell-CAM 105; Ecto-ATPase; GP110; pp120", "protein_names_refseq": "ATP-dependent taurocolate-carrier protein; C-CAM 105; CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin); GP110; bone gamma-carboxyglutamic acid (Gla) protein; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); cell adhesion molecule CEACAM1 isoform 1 precursor; cell adhesion molecule CEACAM1; cell-CAM 105; ecto-ATPase; osteocalcin; pp120/ecto-ATPase; pp120", "tax_id": 10116, "disease": "", "pathway": " (rno:81613); (R-RNO-1566977); (R-RNO-163125); (R-RNO-202733); (R-RNO-6798695)", "pathway_count": 5, "publication_count": 30, "publication_id_list": "11501563;11694516;11850617;11994468;15467833;16054098;16291724;1637321;1831973;19948503;2141577;2373740;24743304;2527235;7518458;7592607;7626603;7774714;8240240;8380406;8420979;8454589;8504806;8513803;8536699;8576129;8831574;9003371;9642150;9712832", "class_list": "", "function": "CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses Publication Status: Online-Only, [RefSeq, PubMed]; Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (PubMed:2373740, PubMed:8454589). Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis (PubMed:11850617). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors (By similarity). Plays a role in immune response, of T-cells, natural killer (NK) and neutrophils (By similarity). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (By similarity). Also inhibits T-cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T-cell through its interaction with HAVCR2 (By similarity). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (By similarity). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome (By similarity). Down-regulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (PubMed:11850617). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis (PubMed:7592607, PubMed:9712832). This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis (PubMed:16054098, PubMed:7592607). INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (PubMed:11694516). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia (By similarity). Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Down-regulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (PubMed:15467833). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interferes with the interaction of FLNA with RALA (By similarity). Mediates bile acid transport activity in a phosphorylation dependent manner (PubMed:7518458). Negatively regulates osteoclastogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Cell adhesion proteins that mediates homophilic cell adhesion in a calcium-independent manner (PubMed:7774714, PubMed:8536699). Promotes populations of T-cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q63093", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0032703 negative regulation of interleukin-2 production;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "P16573-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18508-1", "uniprot_id": [ { "id": "GBRG2_RAT", "url": "https://www.uniprot.org/uniprot/P18508", "type": "external" } ], "mass": 54077.0, "length": 466, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-2", "gene_name": "Gabrg2", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_899156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_899156", "type": "external" } ], "gene_names_uniprotkb": "Gabrg2", "gene_names_refseq": "Gabrg2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2", "protein_names_refseq": "GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2 isoform 2 precursor; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma 2 subunit", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); generalized epilepsy with febrile seizures plus (Disease Ontology:DOID:0060170); familial febrile seizures 8 (Disease Ontology:DOID:0111298); developmental and epileptic encephalopathy 74 (Disease Ontology:DOID:0112210); hepatic encephalopathy (Disease Ontology:DOID:13413); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); childhood absence epilepsy (Disease Ontology:DOID:1825); amphetamine abuse (Disease Ontology:DOID:670); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29709); (R-RNO-977443)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "17003036;2165521;25172774;2561970;28279354;30044221;31894752;32428626;32579917;33958479;38843836;9464994", "class_list": "", "function": "Effect of electroacupuncture on the expression of P2 x 4, GABAA gamma 2 and long-term potentiation in spinal cord of rats with neuropathic pain., [RefSeq, PubMed]; Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2561970, PubMed:30044221). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2561970, PubMed:30044221). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone., [RefSeq, PubMed]; Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation., [RefSeq, PubMed]; Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0030534 adult behavior;GO:0045471 response to ethanol;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P18508-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22509-1", "uniprot_id": [ { "id": "FBRL_RAT", "url": "https://www.uniprot.org/uniprot/P22509", "type": "external" } ], "mass": 34222.0, "length": 327, "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "Fbl", "organism": "Rat", "refseq_name": "rRNA 2'-O-methyltransferase fibrillarin", "refseq_ac": [ { "id": "NP_001020814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020814", "type": "external" } ], "gene_names_uniprotkb": "Fbl", "gene_names_refseq": "Fbl", "protein_names_uniprotkb": "rRNA 2'-O-methyltransferase fibrillarin; 2.1.1.-; Histone-glutamine methyltransferase; Nucleolar protein 1; U6 snRNA 2'-O-methyltransferase fibrillarin", "protein_names_refseq": "U6 snRNA 2'-O-methyltransferase fibrillarin; histone-glutamine methyltransferase; nucleolar protein 1; rRNA 2'-O-methyltransferase fibrillarin", "tax_id": 10116, "disease": "", "pathway": " (rno:292747); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10679015;22673903;2414294", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLH8", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0051117 ATPase binding;GO:0001094 TFIID-class transcription factor complex binding;GO:0008649 rRNA methyltransferase activity;GO:1990259 histone H2AQ104 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0005694 chromosome", "go_biological_process": "GO:0031167 rRNA methylation;GO:0016074 sno(s)RNA metabolic process;GO:0048254 snoRNA localization;GO:0000494 box C/D sno(s)RNA 3'-end processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22509-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35411-1", "uniprot_id": [ { "id": "CX3C1_RAT", "url": "https://www.uniprot.org/uniprot/P35411", "type": "external" } ], "mass": 40327.0, "length": 354, "protein_name": "CX3C chemokine receptor 1", "gene_name": "Cx3cr1", "organism": "Rat", "refseq_name": "CX3C chemokine receptor 1", "refseq_ac": [ { "id": "NP_598218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598218", "type": "external" } ], "gene_names_uniprotkb": "Cx3cr1; Rbs11", "gene_names_refseq": "Cx3cr1; Rbs11", "protein_names_uniprotkb": "CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Fractalkine receptor", "protein_names_refseq": "C-X3-C CKR-1; CX3C chemokine receptor 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; fractalkine receptor", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); age related macular degeneration 12 (Disease Ontology:DOID:0110024); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); sciatic neuropathy (Disease Ontology:DOID:11446); retinal vasculitis (Disease Ontology:DOID:11563); uveitis (Disease Ontology:DOID:13141); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); prion disease (Disease Ontology:DOID:649); psoriasis (Disease Ontology:DOID:8893); hepatopulmonary syndrome (Disease Ontology:DOID:900); systemic lupus erythematosus (Disease Ontology:DOID:9074); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:171056); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "32819407;34339824;34629047;35382731;37868978;8047298", "class_list": "", "function": "Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-kappaB Activity., [RefSeq, PubMed]; FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage regulation of the 'second brain': CD163 intestinal macrophages interact with inhibitory interneurons to regulate colonic motility - evidence from the Cx3cr1-Dtr rat model. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Monocyte perturbation modulates the ovarian response to an immune challenge., [RefSeq, PubMed]; Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:0002931 response to ischemia;GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35411-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09426-1", "uniprot_id": [ { "id": "CGT_RAT", "url": "https://www.uniprot.org/uniprot/Q09426", "type": "external" } ], "mass": 61126.0, "length": 541, "protein_name": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase", "gene_name": "Ugt8", "organism": "Rat", "refseq_name": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor", "refseq_ac": [ { "id": "NP_062149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062149", "type": "external" } ], "gene_names_uniprotkb": "Ugt8; Cgt; Ugt4", "gene_names_refseq": "CGalT; Ugt8a; Ugt8", "protein_names_uniprotkb": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase; 2.4.1.47; CGalT; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase", "protein_names_refseq": "2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; UDP galactosyltransferase 8A; UDP galactosyltransferase 8; UDP-galactose-ceramide galactosyltransferase 8; UDP-glucuronosyltransferase 8; ceramide UDP-galactosyltransferase; cerebroside synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:50555); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "7521399;7694285;8713090", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (PubMed:8713090)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.47", "type": "external" } ], "go_molecular_function": "GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity;GO:0003851 N-acylsphingosine galactosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0042552 myelination;GO:0048812 neuron projection morphogenesis;GO:0007010 cytoskeleton organization;GO:0030913 paranodal junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q09426-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Z0-1", "uniprot_id": [ { "id": "CF298_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Z0", "type": "external" } ], "mass": 33243.0, "length": 290, "protein_name": "Cilia- and flagella-associated protein 298", "gene_name": "Cfap298", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 298", "refseq_ac": [ { "id": "NP_001008289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008289", "type": "external" } ], "gene_names_uniprotkb": "Cfap298", "gene_names_refseq": "Cfap298; RGD1306954", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 298; Protein kurly homolog", "protein_names_refseq": "UPF0769 protein C21orf59 homolog; cilia- and flagella-associated protein 298; protein kurly homolog", "tax_id": 10116, "disease": "primary ciliary dyskinesia 26 (Disease Ontology:DOID:0110627)", "pathway": " (rno:288269)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24094744", "class_list": "", "function": "Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0060271 cilium assembly;GO:0003352 regulation of cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U3Z0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIQ3-1", "uniprot_id": [ { "id": "CXXC5_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIQ3", "type": "external" } ], "mass": 32626.0, "length": 316, "protein_name": "CXXC-type zinc finger protein 5", "gene_name": "Cxxc5", "organism": "Rat", "refseq_name": "CXXC-type zinc finger protein 5", "refseq_ac": [ { "id": "NP_001007629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007629", "type": "external" } ], "gene_names_uniprotkb": "Cxxc5", "gene_names_refseq": "Cxxc5", "protein_names_uniprotkb": "CXXC-type zinc finger protein 5", "protein_names_refseq": "CXXC finger 5; CXXC-type zinc finger protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:291670)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19001364", "class_list": "", "function": "CXXC5 expression overlapped with BMP4 adjacent to Wnt3a expression in the dorsal regions of the telencephalon, including the developing choroid plexus., [RefSeq, PubMed]; May indirectly participate in activation of the NF-kappa-B and MAPK pathways (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (PubMed:19001364). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (By similarity). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008327 methyl-CpG binding;GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043467 regulation of generation of precursor metabolites and energy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64654-1", "uniprot_id": [ { "id": "CP51A_RAT", "url": "https://www.uniprot.org/uniprot/Q64654", "type": "external" } ], "mass": 56707.0, "length": 503, "protein_name": "Lanosterol 14-alpha demethylase", "gene_name": "Cyp51a1", "organism": "Rat", "refseq_name": "lanosterol 14-alpha demethylase", "refseq_ac": [ { "id": "NP_037073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037073", "type": "external" } ], "gene_names_uniprotkb": "Cyp51a1; Cyp51", "gene_names_refseq": "Cyp51a1; Cyp51; RATCP14DM", "protein_names_uniprotkb": "Lanosterol 14-alpha demethylase; 1.14.14.154; CYP51; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; LDM; Sterol 14-alpha demethylase P450", "protein_names_refseq": "CYPLI; Cytochrom P450 Lanosterol 14 alpha-demethylase; LDM; P450-14DM; P45014DM; P450LI; cytochrome P450 51A1; cytochrome P450 Lanosterol 14 alpha-demethylase; cytochrome P450, subfamily 51; cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI; lanosterol 14-alpha demethylase; sterol 14-alpha demethylase P450; sterol 14-alpha demethylase", "tax_id": 10116, "disease": "peeling skin syndrome 4 (Disease Ontology:DOID:0070523); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:25427); (R-RNO-211976); (R-RNO-6807047)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10544287;11328599;1872829;29393594;31352176;3782148;7665087;8024575;8797093;9498553", "class_list": "", "function": "Hypothyroidism changes CYP51 and FSHR expression in ovary, which are regulated by gonadotropin. Moreover, genes changes in ovary are at least partially attributed to steroids biosynthesis., [RefSeq, PubMed]; Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:10544287, PubMed:7665087). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:10544287, PubMed:11328599, PubMed:1872829, PubMed:3782148, PubMed:7665087). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (PubMed:1872829)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 20, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64549", "ec_number_list": [ { "id": "1.14.14.154", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.154", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0008398 sterol 14-demethylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0060282 positive regulation of oocyte development;GO:0007283 spermatogenesis;GO:0010288 response to lead ion;GO:0045540 regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64654-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK11-1", "uniprot_id": [ { "id": "RTN4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK11", "type": "external" } ], "mass": 126388.0, "length": 1163, "protein_name": "Reticulon-4", "gene_name": "Rtn4", "organism": "Rat", "refseq_name": "reticulon-4 isoform X2", "refseq_ac": [ { "id": "XP_006251670", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251670", "type": "external" } ], "gene_names_uniprotkb": "Rtn4; Nogo", "gene_names_refseq": "NI-250; Nogo-A; Nogo; Rtn4; Vp20; rat NogoA; rat N", "protein_names_uniprotkb": "Reticulon-4; Foocen; Glut4 vesicle 20 kDa protein; Neurite outgrowth inhibitor; Nogo protein", "protein_names_refseq": "reticulon-4 isoform X2", "tax_id": 10116, "disease": "hereditary spastic paraplegia 12 (Disease Ontology:DOID:0110765); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:83765); (R-RNO-193634)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10231557;10667796;12037567;12843238;14592966;16641100;18072206;19665976;20573699;22673903", "class_list": "", "function": "Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:12037567, PubMed:12843238, PubMed:20573699). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (By similarity). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK10;Q9R0D9;Q9WUE9;Q9WUF0", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0045296 cadherin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0021553 olfactory nerve development;GO:0045687 positive regulation of glial cell differentiation;GO:1905523 positive regulation of macrophage migration;GO:0071786 endoplasmic reticulum tubular network organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JK11-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97836-1", "uniprot_id": [ { "id": "DLGP1_RAT", "url": "https://www.uniprot.org/uniprot/P97836", "type": "external" } ], "mass": 110178.0, "length": 992, "protein_name": "Disks large-associated protein 1", "gene_name": "Dlgap1", "organism": "Rat", "refseq_name": "disks large-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001291216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291216", "type": "external" } ], "gene_names_uniprotkb": "Dlgap1; Gkap", "gene_names_refseq": "DAP-1; Dlgap1; GKAP/SAPAP1; Gkap; SAPAP1; rGKAP", "protein_names_uniprotkb": "Disks large-associated protein 1; DAP-1; Guanylate kinase-associated protein; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; SAPAP1; rGKAP", "protein_names_refseq": "PSD-95 binding protein; PSD-95/SAP90-binding protein 1; SAP90/PSD-95-associated protein 1; discs large homolog associated protein 1; disks large-associated protein 1 isoform 2; disks large-associated protein 1; guanylate kinase-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:65040); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10433268;10488079;10527873;14760703;16630835;20352094;22673903;23143515;25005096;25775468;27756895;9024696;9115257;9428732;9694864;9756850", "class_list": "", "function": "Activity-dependent turnover of postsynnaptic density proteins orchestrated by GKAP is critical for homeostatic plasticity., [RefSeq, PubMed]; Part of the postsynaptic scaffold in neuronal cells., [UniProtKB]; The C-terminal helical domain of GKAP from Rattus norvegicus was purified and crystallized as a fusion protein., [RefSeq, PubMed]; Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54773;P97841", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0098919 structural constituent of postsynaptic density", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0035418 protein localization to synapse;GO:0061136 regulation of proteasomal protein catabolic process;GO:0070842 aggresome assembly", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P97836-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I6B8-1", "uniprot_id": [ { "id": "PI51C_RAT", "url": "https://www.uniprot.org/uniprot/Q5I6B8", "type": "external" } ], "mass": 75594.0, "length": 688, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma", "gene_name": "Pip5k1c", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform b", "refseq_ac": [ { "id": "NP_001029142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029142", "type": "external" } ], "gene_names_uniprotkb": "Pip5k1c", "gene_names_refseq": "Pip5k1c", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; 2.7.1.68; PIP5K1-gamma; PIP5KIgamma; Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PtdIns(4)P-5-kinase 1 gamma", "protein_names_refseq": "PIP5K1-gamma; PIP5KIgamma; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform b; ptdIns(4)P-5-kinase 1 gamma; ptdIns(4)P-5-kinase gamma; ptdInsPKIgamma", "tax_id": 10116, "disease": "lethal congenital contracture syndrome 3 (Disease Ontology:DOID:0060653); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:314641); (R-RNO-1660499); (R-RNO-399955); (R-RNO-6811558); (R-RNO-8856828); (R-RNO-9768727)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "12847086;14741049;22673903", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments (By similarity). Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) (PubMed:12847086). Required for clathrin-coated pits assembly at the synapse (PubMed:12847086). Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins (By similarity). Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor (By similarity). Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:1990147 talin binding;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098835 presynaptic endocytic zone membrane;GO:0001891 phagocytic cup;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0007409 axonogenesis;GO:0006909 phagocytosis;GO:0070527 platelet aggregation;GO:0006661 phosphatidylinositol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5I6B8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30427-1", "uniprot_id": [ { "id": "PLEC_RAT", "url": "https://www.uniprot.org/uniprot/P30427", "type": "external" } ], "mass": 533540.0, "length": 4687, "protein_name": "Plectin", "gene_name": "Plec", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plec; Plec1", "gene_names_refseq": "", "protein_names_uniprotkb": "Plectin; PCN; PLTN; Plectin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "epidermolysis bullosa simplex 5A Ogna type (Disease Ontology:DOID:0060736); epidermolysis bullosa simplex with muscular dystrophy (Disease Ontology:DOID:0090017); autosomal recessive limb-girdle muscular dystrophy type 2Q (Disease Ontology:DOID:0110285); epidermolysis bullosa simplex (Disease Ontology:DOID:4644)", "pathway": " (R-RNO-264870); (R-RNO-446107)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16641100;2050743;21223964;22673903;38843836;8633055;9177781", "class_list": "", "function": "Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 40, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08879;O08880;O08881", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0002162 dystroglycan binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005903 brush border;GO:0005925 focal adhesion;GO:0030424 axon", "go_biological_process": "GO:0014866 skeletal myofibril assembly;GO:0002522 leukocyte migration involved in immune response;GO:0007015 actin filament organization;GO:0007584 response to nutrient;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30427-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62936-1", "uniprot_id": [ { "id": "DLG3_RAT", "url": "https://www.uniprot.org/uniprot/Q62936", "type": "external" } ], "mass": 93539.0, "length": 849, "protein_name": "Disks large homolog 3", "gene_name": "Dlg3", "organism": "Rat", "refseq_name": "disks large homolog 3", "refseq_ac": [ { "id": "NP_113827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113827", "type": "external" } ], "gene_names_uniprotkb": "Dlg3; Dlgh3", "gene_names_refseq": "Dlg3; Dlgh3", "protein_names_uniprotkb": "Disks large homolog 3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; Synapse-associated protein 102", "protein_names_refseq": "PSD-95/SAP90-related protein 1; SAP-102; SAP102; discs, large homolog 3; disks large homolog 3; synapse-associated protein 102", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); non-syndromic X-linked intellectual disability 90 (Disease Ontology:DOID:0112041); cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:58948); (R-RNO-438066); (R-RNO-451308); (R-RNO-5673001); (R-RNO-6794361); (R-RNO-8849932)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "16495444;19118189;21119615;25555912;29574717;30067114;31682872;33109704;8780649;9115257;9581761", "class_list": "", "function": "Our findings provide fundamental data to support the functional differences of SAP102 in different hippocampal subregions during postnatal periods, [RefSeq, PubMed]; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling., [UniProtKB]; SAP102 contributes to hyperalgesia formation in the cancer induced bone pain rat model by anchoring NMDA receptors., [RefSeq, PubMed]; SAP102 regulates synaptic current kinetics via different AMPAR auxiliary subunits., [RefSeq, PubMed]; These data shed new light on the role of SAP102 in the regulation of NMDAR trafficking., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70547", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0098609 cell-cell adhesion;GO:0043113 receptor clustering;GO:0035418 protein localization to synapse", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62936-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYF3-1", "uniprot_id": [ { "id": "MYO5A_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYF3", "type": "external" } ], "mass": 211764.0, "length": 1828, "protein_name": "Unconventional myosin-Va", "gene_name": "Myo5a", "organism": "Rat", "refseq_name": "unconventional myosin-Va isoform 2", "refseq_ac": [ { "id": "NP_071514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071514", "type": "external" } ], "gene_names_uniprotkb": "Myo5a", "gene_names_refseq": "Dop; Myh12; Myo5a", "protein_names_uniprotkb": "Unconventional myosin-Va; Dilute myosin heavy chain, non-muscle", "protein_names_refseq": "dilute myosin heavy chain, non-muscle; dilute-opisthotonus; myosin 5a; myosin-Va; unconventional myosin-Va isoform 2; unconventional myosin-Va", "tax_id": 10116, "disease": "Griscelli syndrome type 1 (Disease Ontology:DOID:0060832)", "pathway": " (rno:25017); (R-RNO-2029482); (R-RNO-9824585)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10920234;16641100;18683930;19812310;22673903;29217155;30320552;32412091", "class_list": "", "function": "Calcium triggers the dissociation of myosin-Va from ribosomes in ribonucleoprotein complexes., [RefSeq, PubMed]; Myosin V acts as a vesicle tether at the plasma membrane, rather than a motor transporting vesicles to the release sites, or directly regulating vesicle exocytosis. Publication Status: Online-Only, [RefSeq, PubMed]; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; This study identified in vivo neuropathological and biochemical alterative changes involved in the pathogenesis of a spontaneous autosomal recessive movement disorder in a mutant Myo5a juvenile rat model., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005777 peroxisome", "go_biological_process": "GO:1900078 positive regulation of cellular response to insulin stimulus;GO:0048820 hair follicle maturation;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QYF3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GUV7-1", "uniprot_id": [ { "id": "IF2P_RAT", "url": "https://www.uniprot.org/uniprot/B2GUV7", "type": "external" } ], "mass": 137686.0, "length": 1216, "protein_name": "Eukaryotic translation initiation factor 5B", "gene_name": "Eif5b", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 5B", "refseq_ac": [ { "id": "NP_001103611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103611", "type": "external" } ], "gene_names_uniprotkb": "Eif5b; If2", "gene_names_refseq": "Eif5b", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5B; 3.6.5.3; Annexin V-binding protein ABP-7; Translation initiation factor IF-2; eIF-5B", "protein_names_refseq": "annexin V-binding protein ABP-7; eIF-5B; eukaryotic translation initiation factor 5B; translation initiation factor IF-2", "tax_id": 10116, "disease": "", "pathway": " (rno:308306); (R-RNO-72706)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8667030", "class_list": "", "function": "Plays a role in translation initiation. Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. Together with eIF1A (EIF1AX), actively orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after formation of the 80S initiation complex. Its GTPase activity is not essential for ribosomal subunits joining, but GTP hydrolysis is needed for eIF1A (EIF1AX) ejection quickly followed by EIF5B release to form elongation-competent ribosomes. In contrast to its procaryotic homolog, does not promote recruitment of Met-rRNA to the small ribosomal subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN31;P70488", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0042255 ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2GUV7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z340-1", "uniprot_id": [ { "id": "PARD3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z340", "type": "external" } ], "mass": 149448.0, "length": 1337, "protein_name": "Partitioning defective 3 homolog", "gene_name": "Pard3", "organism": "Rat", "refseq_name": "partitioning defective 3 homolog isoform 1", "refseq_ac": [ { "id": "NP_112514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112514", "type": "external" } ], "gene_names_uniprotkb": "Pard3; Par3", "gene_names_refseq": "Par3; Pard3", "protein_names_uniprotkb": "Partitioning defective 3 homolog; ASBP; ASIP; Atypical PKC isotype-specific-interacting protein; Atypical PKC-specific-binding protein; PAR-3; PARD-3", "protein_names_refseq": "ASBP; ASIP; PARD-3; atypical PKC isotype-specific-interacting protein; atypical PKC-specific binding protein; par-3 (partitioning defective 3) homolog; partitioning defective 3 homolog isoform 1; partitioning defective 3 homolog; three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037)", "pathway": " (rno:81918); (R-RNO-2173791); (R-RNO-420029)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "12045219;17476308;18082612;18550519;21949390;22579248;22673903;23946386;25948265;25977476;31868265;32811537;37493885;9763423", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:18550519). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). Targets the phosphatase PTEN to cell junctions (PubMed:18082612)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; PAR3 interacts with PAR6 and NGL-2, acting together to regulate axon differentiation., [RefSeq, PubMed]; Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in glomerular endothelial cell., [RefSeq, PubMed]; Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of Par3 on the cellular junctions and biological functions of odontoblast-lineage cells., [RefSeq, PubMed]; Transcriptional upregulation of Girdin expression and Girdin-Galphai3 signaling play crucial roles in regulating epithelial apicobasal polarity through the PAR complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 15, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019903 protein phosphatase binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0006612 protein targeting to membrane;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9Z340-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9U4-1", "uniprot_id": [ { "id": "PLD3B_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9U4", "type": "external" } ], "mass": 21572.0, "length": 195, "protein_name": "PRELI domain containing protein 3B", "gene_name": "Prelid3b", "organism": "Rat", "refseq_name": "PRELI domain containing protein 3B", "refseq_ac": [ { "id": "NP_001009543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009543", "type": "external" } ], "gene_names_uniprotkb": "Prelid3b; Slmo2", "gene_names_refseq": "Prelid3b; Slmo2", "protein_names_uniprotkb": "PRELI domain containing protein 3B; Protein slowmo homolog 2", "protein_names_refseq": "PRELI domain containing protein 3B; protein slowmo homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:494346)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990050 phosphatidic acid transfer activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P9U4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08589-1", "uniprot_id": [ { "id": "PLM_RAT", "url": "https://www.uniprot.org/uniprot/O08589", "type": "external" } ], "mass": 10365.0, "length": 92, "protein_name": "Phospholemman", "gene_name": "Fxyd1", "organism": "Rat", "refseq_name": "phospholemman isoform X5", "refseq_ac": [ { "id": "XP_006228901", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006228901", "type": "external" } ], "gene_names_uniprotkb": "Fxyd1; Plm", "gene_names_refseq": "Fxyd1; Plm", "protein_names_uniprotkb": "Phospholemman; FXYD domain-containing ion transport regulator 1; Sodium/potassium-transporting ATPase subunit FXYD1", "protein_names_refseq": "phospholemman isoform X5", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:58971); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10950925;12657675;17283221;19187398;19339511;23532852;9169143", "class_list": "", "function": "Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (By similarity). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (PubMed:17283221). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0017022 myosin binding;GO:0099106 ion channel regulator activity", "go_cellular_component": "GO:0014704 intercalated disc;GO:0016324 apical plasma membrane;GO:0005901 caveola;GO:0042383 sarcolemma;GO:0030315 T-tubule", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:0086004 regulation of cardiac muscle cell contraction;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08589-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88763-1", "uniprot_id": [ { "id": "PK3C3_RAT", "url": "https://www.uniprot.org/uniprot/O88763", "type": "external" } ], "mass": 101534.0, "length": 887, "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "Pik3c3", "organism": "Rat", "refseq_name": "phosphatidylinositol 3-kinase catalytic subunit type 3", "refseq_ac": [ { "id": "NP_075247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075247", "type": "external" } ], "gene_names_uniprotkb": "Pik3c3; Vps34", "gene_names_refseq": "Pik3c3", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase catalytic subunit type 3; 2.7.1.137; PI3-kinase type 3; PI3K type 3; Phosphoinositide-3-kinase class 3; PtdIns-3-kinase type 3", "protein_names_refseq": "PI-3K Vps34p; PI3-kinase type 3; PI3K type 3; catalytic phosphatidylinositol 3-kinase 3; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; ptdIns-3-kinase type 3", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (rno:65052); (R-RNO-109704); (R-RNO-1632852); (R-RNO-1660514); (R-RNO-1660516); (R-RNO-1660517); (R-RNO-168138); (R-RNO-5668599)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "11171063;11773707;11839273;11861821;11880313;22673903;25046113;27021411", "class_list": "", "function": "Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Involved in the transport of lysosomal enzyme precursors to lysosomes (PubMed:11171063). Required for transport from early to late endosomes (PubMed:11171063)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data show that the cardioprotective effect of paeonol and danshensu combination is, at least partly, via activation of Nrf2/HO-1 signaling and involvement of the PI3K/Akt cell survival signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Oxidative stress induces activation of PI3K, which leads to p70S6K1 activation and enlargement of cell size, [RefSeq, PubMed]; Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration., [RefSeq, PubMed]; Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells., [RefSeq, PubMed]; Reveal a novel function of GABP in the regulation of autophagy via transcriptional activation of the BECN1-PIK3C3 complex, [RefSeq, PubMed]; Secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0000045 autophagosome assembly;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88763-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52164-1", "uniprot_id": [ { "id": "MAX_RAT", "url": "https://www.uniprot.org/uniprot/P52164", "type": "external" } ], "mass": 18272.0, "length": 160, "protein_name": "Protein max", "gene_name": "Max", "organism": "Rat", "refseq_name": "protein max isoform 1", "refseq_ac": [ { "id": "NP_071546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071546", "type": "external" } ], "gene_names_uniprotkb": "Max", "gene_names_refseq": "Max", "protein_names_uniprotkb": "Protein max; Myc-associated factor X", "protein_names_refseq": "MYC associated factor X; myc-associated factor X; protein max isoform 1; protein max", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); lung small cell carcinoma (Disease Ontology:DOID:5409); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:60661); (R-RNO-8953750)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17304222;20197614;22673903;35103748;8268234", "class_list": "", "function": "Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration., [RefSeq, PubMed]; The positive rate of Max expression was significantly lower in ductal adenocarcinoma in the control group., [RefSeq, PubMed]; Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030425 dendrite;GO:0016605 PML body;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52164-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47860-1", "uniprot_id": [ { "id": "PFKAP_RAT", "url": "https://www.uniprot.org/uniprot/P47860", "type": "external" } ], "mass": 85720.0, "length": 788, "protein_name": "ATP-dependent 6-phosphofructokinase, platelet type", "gene_name": "Pfkp", "organism": "Rat", "refseq_name": "ATP-dependent 6-phosphofructokinase, platelet type", "refseq_ac": [ { "id": "NP_996729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996729", "type": "external" } ], "gene_names_uniprotkb": "Pfkp; Pfkc", "gene_names_refseq": "ATP-PFK; PFK-C; PFK-P; Pfkp; pfkc", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, platelet type; 2.7.1.11; 6-phosphofructokinase type C; ATP-PFK; PFK-C; PFK-P; Phosphofructo-1-kinase isozyme C; Phosphohexokinase", "protein_names_refseq": "6-phosphofructo-1-kinase, C-type; 6-phosphofructokinase type C; ATP-dependent 6-phosphofructokinase, platelet type; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphofructokinase C-type subunit; phosphohexokinase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:60416); (R-RNO-70171)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18683930;22673903;38843836;8106374", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5HZX8", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P47860-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIR4-1", "uniprot_id": [ { "id": "RIMS1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIR4", "type": "external" } ], "mass": 179655.0, "length": 1615, "protein_name": "Regulating synaptic membrane exocytosis protein 1", "gene_name": "Rims1", "organism": "Rat", "refseq_name": "regulating synaptic membrane exocytosis protein 1 isoform 2", "refseq_ac": [ { "id": "NP_439894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_439894", "type": "external" } ], "gene_names_uniprotkb": "Rims1; Rim1", "gene_names_refseq": "RIM1a; Rim1; Rims1", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 1; RIM 1; Rab-3-interacting molecule 1", "protein_names_refseq": "RIM 1; Rab3 effector; Rim1b protein; rab-3-interacting molecule 1; rab3-interacting molecule 1; regulating synaptic membrane exocytosis protein 1 isoform 2; regulating synaptic membrane exocytosis protein 1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:84556); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-888590)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10748113;11797009;12871946;16095618;16630837;16641100;16704978;17630786;18683930;22673903;24290762;27115346;30661983;38843836;40493522;9252191", "class_list": "", "function": "RIM1a and RIM-BP2 are plausible organizers of active zones, and the formation of RIM and RIM-BP condensates may cluster voltage gated calcium channels into nano- or microdomains and position the clustered Ca(2+) channels with Ca(2+) sensors on docked vesicles for efficient and precise synaptic transmissions., [RefSeq, PubMed]; RIM1alpha SUMOylation at K502 is required for its binding to Cav2.1 and for fast synaptic vesicle exocytosis., [RefSeq, PubMed]; Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 24, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O35168", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JIR4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69735-1", "uniprot_id": [ { "id": "RB3GP_RAT", "url": "https://www.uniprot.org/uniprot/P69735", "type": "external" } ], "mass": 86587.0, "length": 775, "protein_name": "Rab3 GTPase-activating protein catalytic subunit", "gene_name": "Rab3gap1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rab3gap1; RGD1306487; Rab3gap", "gene_names_refseq": "", "protein_names_uniprotkb": "Rab3 GTPase-activating protein catalytic subunit; RAB3 GTPase-activating protein 130 kDa subunit; Rab3-GAP p130; Rab3-GAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "Warburg micro syndrome (Disease Ontology:DOID:0060237); Warburg micro syndrome 1 (Disease Ontology:DOID:0110716)", "pathway": " (R-RNO-6811436); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11809763;9030515;9733780", "class_list": "", "function": "Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. Has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43. Additionally, it has guanine nucleotide exchange factor (GEF) activity towards RAB18, promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and is involved in regulating non-synaptic vesicular release of neurotransmitters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0098794 postsynapse;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0097051 establishment of protein localization to endoplasmic reticulum membrane;GO:0010628 positive regulation of gene expression;GO:0060079 excitatory postsynaptic potential;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P69735-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDU4-1", "uniprot_id": [ { "id": "LERL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDU4", "type": "external" } ], "mass": 14400.0, "length": 131, "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "Leprotl1", "organism": "Rat", "refseq_name": "leptin receptor overlapping transcript-like 1", "refseq_ac": [ { "id": "NP_001013206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013206", "type": "external" } ], "gene_names_uniprotkb": "Leprotl1", "gene_names_refseq": "Leprotl1", "protein_names_uniprotkb": "Leptin receptor overlapping transcript-like 1; Endospanin-2", "protein_names_refseq": "endospanin-2; leptin receptor overlapping transcript-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361160)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23772379", "class_list": "", "function": "Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PDU4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS0-1", "uniprot_id": [ { "id": "PKHM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS0", "type": "external" } ], "mass": 117508.0, "length": 1059, "protein_name": "Pleckstrin homology domain-containing family M member 1", "gene_name": "Plekhm1", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family M member 1", "refseq_ac": [ { "id": "NP_001009677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009677", "type": "external" } ], "gene_names_uniprotkb": "Plekhm1", "gene_names_refseq": "Plekhm1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family M member 1; PH domain-containing family M member 1", "protein_names_refseq": "PH domain-containing family M member 1; pleckstrin homology domain containing, family M (with RUN domain) member 1; pleckstrin homology domain-containing family M member 1", "tax_id": 10116, "disease": "autosomal recessive osteopetrosis 6 (Disease Ontology:DOID:0110945); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (rno:303584)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17404618;22673903;29393594", "class_list": "", "function": "Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:17404618). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals (By similarity). Involved in bone resorption (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005764 lysosome;GO:0031902 late endosome membrane;GO:0044754 autolysosome;GO:0120281 autolysosome membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045780 positive regulation of bone resorption;GO:0032418 lysosome localization;GO:1902774 late endosome to lysosome transport;GO:1900029 positive regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PQS0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70581-1", "uniprot_id": [ { "id": "NUP58_RAT", "url": "https://www.uniprot.org/uniprot/P70581", "type": "external" } ], "mass": 59265.0, "length": 585, "protein_name": "Nucleoporin p58/p45", "gene_name": "Nup58", "organism": "Rat", "refseq_name": "nucleoporin p58/p45", "refseq_ac": [ { "id": "NP_620791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620791", "type": "external" } ], "gene_names_uniprotkb": "Nup58; Nupl1", "gene_names_refseq": "Nup45; Nup58; Nupl1; p58/p45", "protein_names_uniprotkb": "Nucleoporin p58/p45; 58 kDa nucleoporin; Nucleoporin-like protein 1", "protein_names_refseq": "58 kDa nucleoporin; nucleoporin p45; nucleoporin p58/p45; nucleoporin p58; nucleoporin-like 1; nucleoporin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:245922); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 6, "publication_id_list": "17379812;22036567;24574455;26025361;8707840;9795236", "class_list": "", "function": "A 1:1:1 stoichiometry of the Nup62 complex, where Nup54 is central with direct binding to Nup62 and Nup58., [RefSeq, PubMed]; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane., [UniProtKB, PubMed]; Crystal structure of alpha-helical region of Nup58/45; we identified distinct tetramers, each consisting of two antiparallel hairpin dimers [Nup58, Nup45], [RefSeq, PubMed]; Study reports the crystal structures of the Nup54-Nup58 and Nup62-Nup54 interacting domains and reconstruct the molecular architecture of the NPC transport channel., [RefSeq, PubMed]; We carried out solution analysis utilizing the entire ordered regions of Nup62, Nup54, and Nup58, and demonstrate that they form a dynamic 'triple complex', [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHE1;Q9QWK7;Q9Z2W7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051028 mRNA transport;GO:0042306 regulation of protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70581-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08603-1", "uniprot_id": [ { "id": "PGTB2_RAT", "url": "https://www.uniprot.org/uniprot/Q08603", "type": "external" } ], "mass": 36856.0, "length": 331, "protein_name": "Geranylgeranyl transferase type-2 subunit beta", "gene_name": "Rabggtb", "organism": "Rat", "refseq_name": "geranylgeranyl transferase type-2 subunit beta", "refseq_ac": [ { "id": "NP_619715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619715", "type": "external" } ], "gene_names_uniprotkb": "Rabggtb; Ggtb", "gene_names_refseq": "Rabggtb", "protein_names_uniprotkb": "Geranylgeranyl transferase type-2 subunit beta; 2.5.1.60; GGTase-II-beta; Geranylgeranyl transferase type II subunit beta; Rab GG transferase beta; Rab GGTase beta; Rab geranyl-geranyltransferase subunit beta; Rab geranylgeranyltransferase subunit beta; Type II protein geranyl-geranyltransferase subunit beta", "protein_names_refseq": "GGTase-II-beta; Rab geranylgeranyl transferase componenet, subunit beta; Rab geranylgeranyltransferase, beta subunit; geranylgeranyl transferase type II subunit beta; geranylgeranyl transferase type-2 subunit beta; rab GG transferase beta; rab GGTase beta; rab geranyl-geranyltransferase subunit beta; type II protein geranyl-geranyltransferase subunit beta", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); hereditary angioedema type III (Disease Ontology:DOID:0080940); acquired angioedema (Disease Ontology:DOID:0080941); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); factor XII deficiency (Disease Ontology:DOID:2231); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); myocardial infarction (Disease Ontology:DOID:5844); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25533); (R-RNO-6803205); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "10745007;11675392;12620235;18399557;18756270;19894725;22480322;22963166;23114750;8505342", "class_list": "", "function": "Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; SiRNA-mediated knockdown of alpha- or beta-subunits of RGGT and REP1 markedly attenuates glucose-stimulated insulin secretion in insulin 832/13 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0019840 isoprenoid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0018344 protein geranylgeranylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q08603-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83871-1", "uniprot_id": [ { "id": "PHF5A_RAT", "url": "https://www.uniprot.org/uniprot/P83871", "type": "external" } ], "mass": 12405.0, "length": 110, "protein_name": "PHD finger-like domain-containing protein 5A", "gene_name": "Phf5a", "organism": "Rat", "refseq_name": "PHD finger-like domain-containing protein 5A", "refseq_ac": [ { "id": "NP_620243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620243", "type": "external" } ], "gene_names_uniprotkb": "Phf5a; Ini", "gene_names_refseq": "Ac2-246; Phf5a", "protein_names_uniprotkb": "PHD finger-like domain-containing protein 5A; PHD finger-like domain protein 5A; SF3b14b; Splicing factor 3B-associated 14 kDa protein", "protein_names_refseq": "PHD finger-like domain protein 5A; PHD finger-like domain-containing protein 5A; SF3b14b; splicing factor 3B-associated 14 kDa protein; transcription factor INI", "tax_id": 10116, "disease": "", "pathway": " (rno:192246); (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12810571", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (By similarity). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (By similarity). Within the 17S U2 SnRNP complex, PHF5A is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA (By similarity). Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity). Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Also involved in elongation by RNA polymerase II as part of the PAF1 complex (PAF1C) (By similarity). PAF1C is required for maintenance of embryonic stem cell (ESC) self-renewal and cellular reprogramming of stem cells (By similarity). Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes (By similarity). Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes (By similarity). Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies (By similarity). Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity). Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (PubMed:12810571)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; That Ini's physiological role in myometrium is to modulate the response of the cx43 gene to estrogen., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048863 stem cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63625-1", "uniprot_id": [ { "id": "PHRF1_RAT", "url": "https://www.uniprot.org/uniprot/Q63625", "type": "external" } ], "mass": 184214.0, "length": 1685, "protein_name": "PHD and RING finger domain-containing protein 1", "gene_name": "Phrf1", "organism": "Rat", "refseq_name": "PHD and RING finger domain-containing protein 1 isoform X3", "refseq_ac": [ { "id": "XP_006230576", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230576", "type": "external" } ], "gene_names_uniprotkb": "Phrf1", "gene_names_refseq": "Phrf1", "protein_names_uniprotkb": "PHD and RING finger domain-containing protein 1; CTD-binding SR-like protein rA9", "protein_names_refseq": "PHD and RING finger domain-containing protein 1 isoform X3", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "22673903;29393594;8692929", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63625-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTP0-1", "uniprot_id": [ { "id": "E41L1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTP0", "type": "external" } ], "mass": 98243.0, "length": 879, "protein_name": "Band 4.1-like protein 1", "gene_name": "Epb41l1", "organism": "Rat", "refseq_name": "band 4.1-like protein 1 isoform S", "refseq_ac": [ { "id": "NP_742087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742087", "type": "external" } ], "gene_names_uniprotkb": "Epb41l1; Epb4.1l1", "gene_names_refseq": "4.1N; Epb4.1l1; Epb41l1", "protein_names_uniprotkb": "Band 4.1-like protein 1; 4.1N; Erythrocyte membrane protein band 4.1-like 1; Neuronal protein 4.1", "protein_names_refseq": "band 4.1-like protein 1 isoform S; band 4.1-like protein 1-like; erythrocyte protein band 4.1-like 1; neuronal protein 4.1", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant intellectual developmental disorder 11 (Disease Ontology:DOID:0070041)", "pathway": " (rno:59317); (R-RNO-399719); (R-RNO-6794361)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10407168;15340146;16641100;17335044;17496889;18683930;19322778;19503082;21389686;22673903;23400781", "class_list": "", "function": "4.1N was expressed postsynaptically at the climbing fibers synapse at early ages during Purkinje cell dendritic growth; its expression changed from neurons to Bergmann glia once these glial cells had completed their enwrapping process., [RefSeq, PubMed]; Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis, [RefSeq, PubMed]; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases., [UniProtKB]; Study describes a previously unknown mechanism that governs activity-dependent GluR1 trafficking, reveals an interaction between AMPAR palmitoylation and phosphorylation, and underscores the importance of 4.1N in AMPAR trafficking and synaptic plasticity., [RefSeq, PubMed]; Type I inositol 1,4,5-trisphosphate receptor (IP3R1) localization via protein 4.1N is necessary for divalent calcium ion wave (Ca2+) formation, which in turn mediates neurite formation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 31, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9WTP1", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098794 postsynapse;GO:0097060 synaptic membrane", "go_biological_process": "GO:0031032 actomyosin structure organization;GO:0030866 cortical actin cytoskeleton organization;GO:0099145 regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9WTP0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88453-1", "uniprot_id": [ { "id": "SAFB1_RAT", "url": "https://www.uniprot.org/uniprot/O88453", "type": "external" } ], "mass": 104567.0, "length": 931, "protein_name": "Scaffold attachment factor B1", "gene_name": "Safb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Safb; Safb1", "gene_names_refseq": "", "protein_names_uniprotkb": "Scaffold attachment factor B1; SAF-B1; SAF-B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-3899300)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11118435;22673903;9671816", "class_list": "", "function": "Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030496 midbody", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0040008 regulation of growth;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042445 hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88453-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7B7-1", "uniprot_id": [ { "id": "DUS15_RAT", "url": "https://www.uniprot.org/uniprot/B4F7B7", "type": "external" } ], "mass": 26309.0, "length": 236, "protein_name": "Dual specificity protein phosphatase 15", "gene_name": "Dusp15", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 15 isoform 1", "refseq_ac": [ { "id": "NP_001102068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102068", "type": "external" } ], "gene_names_uniprotkb": "Dusp15", "gene_names_refseq": "Dusp15", "protein_names_uniprotkb": "Dual specificity protein phosphatase 15; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity phosphatase-like 15; dual specificity protein phosphatase 15 isoform 1; dual specificity protein phosphatase 15", "tax_id": 10116, "disease": "", "pathway": " (rno:362238)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27532821;27891578", "class_list": "", "function": "May play a role in the regulation of oligodendrocyte differentiation. May play a role in the regulation of myelin formation (PubMed:27532821). Involved in the regulation of Erk1/2 phosphorylation in Schwann cells; the signaling may be linked to the regulation of myelination (PubMed:27891578). May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0016311 dephosphorylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0048713 regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B4F7B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6URK4-1", "uniprot_id": [ { "id": "ROA3_RAT", "url": "https://www.uniprot.org/uniprot/Q6URK4", "type": "external" } ], "mass": 39652.0, "length": 379, "protein_name": "Heterogeneous nuclear ribonucleoprotein A3", "gene_name": "Hnrnpa3; LOC100911361; LOC120096281", "organism": "Rat", "refseq_name": "heterogeneous nuclear ribonucleoprotein A3 isoform a", "refseq_ac": [ { "id": "NP_001104764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104764", "type": "external" } ], "gene_names_uniprotkb": "Hnrnpa3; LOC100911361; LOC120096281; Hnrnpa3; Hnrpa3; LOC120096281", "gene_names_refseq": "Hnrnpa3; Hnrpa3; mBx", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein A3; hnRNP A3", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein A3 isoform a; hnRNP A3", "tax_id": 10116, "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); silicosis (Disease Ontology:DOID:10325); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:362152); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11886857;16396499;18683930;22673903;24098712;27461252;29393594;34502162;38843836", "class_list": "", "function": "Has a role in cytoplasmic trafficking of RNA (heterogenous nuclear ribonucleoprotein A3), [RefSeq, PubMed]; Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition., [RefSeq, PubMed]; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6URK3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0051033 RNA transmembrane transporter activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0098794 postsynapse", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6URK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54921-1", "uniprot_id": [ { "id": "SNAA_RAT", "url": "https://www.uniprot.org/uniprot/P54921", "type": "external" } ], "mass": 33193.0, "length": 295, "protein_name": "Alpha-soluble NSF attachment protein", "gene_name": "Napa", "organism": "Rat", "refseq_name": "alpha-soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_542152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542152", "type": "external" } ], "gene_names_uniprotkb": "Napa; Snapa; Snap", "gene_names_refseq": "Napa; alpha-SNAP", "protein_names_uniprotkb": "Alpha-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein alpha; SNAP-alpha", "protein_names_refseq": "N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; SNAP-alpha; alpha-soluble NSF attachment protein", "tax_id": 10116, "disease": "temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:140673); (R-RNO-204005); (R-RNO-432722); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "11931741;18683930;25278303;26156199;37979021;9507000;9614193", "class_list": "", "function": "AlphaSNAP expression showed no change in pilocarpine-induced epileptic rats in the acute phase, but in the chronic phase levels were lower. siRNA decreased the time of latency to seizure and increased the incidence of chronic idiopathic epilepsy seizures., [RefSeq, PubMed]; Analysis of NAPA Gene Expression in Brain Structures of Wistar Rats during the Formation of Long-Term Spatial Memory and Physical Activity under Stress Situation., [RefSeq, PubMed]; In severe acute pancreatitis, downregulated expression of alphaSNAP in intestinal epithelial cells leads to reduced occludin expression, apoptosis of intestinal epithelial cells, and increased permeability of the intestinal barrier., [RefSeq, PubMed]; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB]; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0035249 synaptic transmission, glutamatergic;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P54921-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920G0-1", "uniprot_id": [ { "id": "SKAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q920G0", "type": "external" } ], "mass": 40717.0, "length": 358, "protein_name": "Src kinase-associated phosphoprotein 2", "gene_name": "Skap2", "organism": "Rat", "refseq_name": "src kinase-associated phosphoprotein 2", "refseq_ac": [ { "id": "NP_569097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569097", "type": "external" } ], "gene_names_uniprotkb": "Skap2; Scap2; Skap55r", "gene_names_refseq": "Scap2; Scap55r; Skap2", "protein_names_uniprotkb": "Src kinase-associated phosphoprotein 2; SKAP-55HOM; SKAP-HOM; SKAP55 homolog; SKAP55-HOM; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein", "protein_names_refseq": "Fyn-associated protein; SKAP-55HOM; SKAP-HOM; SKAP55 homolog; SKAP55-HOM; Src kinase-associated phosphoprotein; adaptor protein; src family-associated phosphoprotein 2; src kinase-associated phosphoprotein 2; src kinase-associated phosphoprotein 55-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:155183); (R-RNO-391160)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0042113 B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920G0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIM4-1", "uniprot_id": [ { "id": "DUS12_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIM4", "type": "external" } ], "mass": 37196.0, "length": 339, "protein_name": "Dual specificity protein phosphatase 12", "gene_name": "Dusp12", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 12", "refseq_ac": [ { "id": "NP_071584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071584", "type": "external" } ], "gene_names_uniprotkb": "Dusp12; Gkap", "gene_names_refseq": "Dusp12; GKAP", "protein_names_uniprotkb": "Dual specificity protein phosphatase 12; 3.1.3.16; 3.1.3.48; GKAP; Glucokinase-associated dual specificity phosphatase", "protein_names_refseq": "dual specificity protein phosphatase 12; glucokinase-associated dual specificity phosphatase; glucokinase-associated phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:64014)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10913113;36644958", "class_list": "", "function": "DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy., [RefSeq, PubMed]; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019900 kinase binding;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0006470 protein dephosphorylation;GO:1903301 positive regulation of hexokinase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQJ5-1", "uniprot_id": [ { "id": "RHG29_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQJ5", "type": "external" } ], "mass": 141943.0, "length": 1266, "protein_name": "Rho GTPase-activating protein 29", "gene_name": "Arhgap29", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 29 isoform 3", "refseq_ac": [ { "id": "NP_001009405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009405", "type": "external" } ], "gene_names_uniprotkb": "Arhgap29; Abca4", "gene_names_refseq": "Arhgap29; B130017i01rik; RGD1306185", "protein_names_uniprotkb": "Rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29", "protein_names_refseq": "PTPL1-associated RhoGAP 1; rho GTPase-activating protein 29 isoform 3; rho GTPase-activating protein 29; rho-type GTPase-activating protein 29", "tax_id": 10116, "disease": "EEC syndrome (Disease Ontology:DOID:0060782); retinitis pigmentosa 91 (Disease Ontology:DOID:0061106); age related macular degeneration 2 (Disease Ontology:DOID:0110015); retinitis pigmentosa 19 (Disease Ontology:DOID:0110354); cone-rod dystrophy 3 (Disease Ontology:DOID:0111013); retinitis pigmentosa (Disease Ontology:DOID:10584); macular degeneration (Disease Ontology:DOID:4448); retinal degeneration (Disease Ontology:DOID:8466); fundus dystrophy (Disease Ontology:DOID:8501)", "pathway": " (rno:310833); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0030165 PDZ domain binding;GO:0016887 ATP hydrolysis activity;GO:0005503 all-trans retinal binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005783 endoplasmic reticulum;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:0006649 phospholipid transfer to membrane;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQJ5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54861-1", "uniprot_id": [ { "id": "SORT_RAT", "url": "https://www.uniprot.org/uniprot/O54861", "type": "external" } ], "mass": 91169.0, "length": 825, "protein_name": "Sortilin", "gene_name": "Sort1", "organism": "Rat", "refseq_name": "sortilin precursor", "refseq_ac": [ { "id": "NP_113955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113955", "type": "external" } ], "gene_names_uniprotkb": "Sort1", "gene_names_refseq": "Nt3; Nts3; Sort1", "protein_names_uniprotkb": "Sortilin; Glycoprotein 110; Gp110; NTR3; Neurotensin receptor 3", "protein_names_refseq": "NTR3; glycoprotein 110; gp110; neurotensin receptor 3; sortilin precursor", "tax_id": 10116, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (rno:83576); (R-RNO-432722)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "12746864;12771154;15987945;21454685;22673903;24090084;26479776;29196163;29393594;34626084;36859404;38305117;9305862;9452485", "class_list": "", "function": "A luciferase reporter assay confirmed that SORT1 is the direct target of miR-182. Our study suggests that SORT1 plays a vital role in the development of arterial calcification and is regulated by miR-182., [RefSeq, PubMed]; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin (By similarity). May also mediate transport from the endoplasmic reticulum to the Golgi (PubMed:12771154)., [UniProtKB, PubMed, UniProtKB]; Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture., [RefSeq, PubMed]; Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells. Erratum:[Sci Rep. 2023 Mar 13;13(1):4152. doi: 10.1038/s41598-023-31255-x. PMID: 36914707] Publication Status: Online-Only, [RefSeq, PubMed]; Sortilin regulates blood-brain barrier integrity., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O35389", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0016492 G protein-coupled neurotensin receptor activity;GO:0019899 enzyme binding;GO:0030379 neurotensin receptor activity, non-G protein-coupled;GO:0010465 nerve growth factor receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O54861-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53534-1", "uniprot_id": [ { "id": "PYGB_RAT", "url": "https://www.uniprot.org/uniprot/P53534", "type": "external" } ], "mass": 96174.0, "length": 838, "protein_name": "Glycogen phosphorylase, brain form", "gene_name": "Pygb", "organism": "Rat", "refseq_name": "glycogen phosphorylase, brain form", "refseq_ac": [ { "id": "NP_037320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037320", "type": "external" } ], "gene_names_uniprotkb": "Pygb", "gene_names_refseq": "GLYPHOA; Pygb", "protein_names_uniprotkb": "Glycogen phosphorylase, brain form; 2.4.1.1", "protein_names_refseq": "brain glycogen phosphorylase; brain; glycogen phosphorylase, brain form; phosphorylase, glycogen", "tax_id": 10116, "disease": "glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:25739); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "16879805;17442042;18683930;22673903;29393594;3209063;34502162;7916624", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Glycogen phosphorylase that regulates glycogen mobilization (By similarity). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB, PubMed, UniProtKB]; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Thus, glycogen is an active fuel for specific structures in normal activated brain, not simply an emergency fuel depot and flux-generated pyruvate greatly exceeded net accumulation of lactate or net consumption of glycogen during activation. T, [RefSeq, PubMed]; We have demonstrated immunocytochemically the presence of glycogen phosphorylase, brain form in large and small axons of the rat vagus nerve, but not in Schwann cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P53534-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PST4-1", "uniprot_id": [ { "id": "ATLA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6PST4", "type": "external" } ], "mass": 63375.0, "length": 558, "protein_name": "Atlastin-1", "gene_name": "Atl1", "organism": "Rat", "refseq_name": "atlastin-1", "refseq_ac": [ { "id": "NP_001009831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009831", "type": "external" } ], "gene_names_uniprotkb": "Atl1; Spg3a", "gene_names_refseq": "Atl1; Spg3a", "protein_names_uniprotkb": "Atlastin-1; 3.6.5.-; Spastic paraplegia 3A homolog", "protein_names_refseq": "atlastin-1; spastic paraplegia 3A homolog", "tax_id": 10116, "disease": "hereditary sensory neuropathy type 1D (Disease Ontology:DOID:0070156); hereditary spastic paraplegia 3A (Disease Ontology:DOID:0110791); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:362750)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "14506257;16537571;19665976;20816793;22673903;23079343;24262037", "class_list": "", "function": "Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed:16537571). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). May also regulate more or less directly Golgi biogenesis (PubMed:16537571). Indirectly regulates axonal development (PubMed:16537571)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Data suggest that NIPA1 and atlastin-1 are members of a common biochemical pathway that supports axonal maintenance, which may explain in part the characteristic degeneration of long spinal pathways observed in patients with HSP., [RefSeq, PubMed]; SPG3A protein atlastin-1 is enriched in growth cones and promotes axon elongation during neuronal development, [RefSeq, PubMed]; These results further supports the role of the atlastin-1 of BMP signaling cascade in axonal maintenance and axonal degeneration, which is seen in various types of hereditary spastic paraplegia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007409 axonogenesis;GO:0051260 protein homooligomerization;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6PST4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19222-1", "uniprot_id": [ { "id": "CBPA2_RAT", "url": "https://www.uniprot.org/uniprot/P19222", "type": "external" } ], "mass": 46912.0, "length": 417, "protein_name": "Carboxypeptidase A2", "gene_name": "Cpa2; Cpa4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cpa2; Cpa4; Cpa2; Cpa4", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxypeptidase A2; 3.4.17.15", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296959); (rno:502736)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1761558;3182871;7657630", "class_list": "", "function": "Carboxypeptidase that catalyzes the release of a C-terminal amino acid, with a preference for large aromatic C-terminal residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD54", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0042447 hormone catabolic process;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19222-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H267-1", "uniprot_id": [ { "id": "SNX5_RAT", "url": "https://www.uniprot.org/uniprot/B1H267", "type": "external" } ], "mass": 46793.0, "length": 404, "protein_name": "Sorting nexin-5", "gene_name": "Snx5", "organism": "Rat", "refseq_name": "sorting nexin-5", "refseq_ac": [ { "id": "NP_001386227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386227", "type": "external" } ], "gene_names_uniprotkb": "Snx5", "gene_names_refseq": "Snx5", "protein_names_uniprotkb": "Sorting nexin-5", "protein_names_refseq": "sorting nexin-5", "tax_id": 10116, "disease": "", "pathway": " (rno:296199); (R-RNO-432722)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16487940;19553671;29393594;34134000", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity)., [UniProtKB, UniProtKB]; Overexpression of SNX5 inhibits the degradation of epidermal growth factor (EGF) receptor., [RefSeq, PubMed]; Super-enhancer-driven Sorting Nexin 5 expression promotes dopaminergic neuronal ferroptosis in Parkinson's disease models., [RefSeq, PubMed]; The phox domain of SNX5 preferentially binds to phosphatidylinositol 4,5-bisphosphate., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005768 endosome;GO:0005829 cytosol;GO:0005903 brush border;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045776 negative regulation of blood pressure;GO:0045893 positive regulation of DNA-templated transcription;GO:0042147 retrograde transport, endosome to Golgi;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B1H267-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PQA9-1", "uniprot_id": [ { "id": "KINH_RAT", "url": "https://www.uniprot.org/uniprot/Q2PQA9", "type": "external" } ], "mass": 109531.0, "length": 963, "protein_name": "Kinesin-1 heavy chain", "gene_name": "Kif5b", "organism": "Rat", "refseq_name": "kinesin-1 heavy chain", "refseq_ac": [ { "id": "NP_476550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476550", "type": "external" } ], "gene_names_uniprotkb": "Kif5b; Khc", "gene_names_refseq": "Khc; Kif5b", "protein_names_uniprotkb": "Kinesin-1 heavy chain; Conventional kinesin heavy chain; UKHC; Ubiquitous kinesin heavy chain", "protein_names_refseq": "UKHC; conventional kinesin heavy chain; kinesin-1 heavy chain; ubiquitous kinesin heavy chain", "tax_id": 10116, "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); neurodegenerative disease (Disease Ontology:DOID:1289); motor neuron disease (Disease Ontology:DOID:231); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:117550); (R-RNO-2132295); (R-RNO-5625970); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10573845;22673903;23011729;23576431;24995978;30978476;33953268;34154701;36773735;38843836;7514426", "class_list": "", "function": "Correlative increasing expressions of KIF5b and Nav1.7 in DRG neurons of rats under neuropathic pain conditions., [RefSeq, PubMed]; High intensity interval training (HIIT) is associated with the down-regulation of gene and protein levels of KIF5B and Dynein in the rat hippocampal tissue, although the underlying mechanisms have remained unknown. These changes suggest that HIIT may have negative effects on both the anterograde and retrograde cytoplasmic transports because the cytoplasmic transport is mediated by KIF5B and Dynein., [RefSeq, PubMed]; Kinesin-1-dependent transport of the betaPIX/GIT complex in neuronal cells., [RefSeq, PubMed]; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The effects of exercise training on Kinesin and GAP-43 expression in skeletal muscle fibers of STZ-induced diabetic rats. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WV65", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule;GO:0035253 ciliary rootlet", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0099641 anterograde axonal protein transport;GO:0042391 regulation of membrane potential;GO:0090316 positive regulation of intracellular protein transport;GO:0021766 hippocampus development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q2PQA9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQX4-1", "uniprot_id": [ { "id": "RHG44_RAT", "url": "https://www.uniprot.org/uniprot/F1LQX4", "type": "external" } ], "mass": 89115.0, "length": 814, "protein_name": "Rho GTPase-activating protein 44", "gene_name": "Arhgap44", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 44", "refseq_ac": [ { "id": "NP_001406525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406525", "type": "external" } ], "gene_names_uniprotkb": "Arhgap44; Rich2", "gene_names_refseq": "Arhgap44; RGD1305664; RICH-2", "protein_names_uniprotkb": "Rho GTPase-activating protein 44; RICH-2; Rho-type GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2", "protein_names_refseq": "rho GTPase-activating protein 44; rho-type GTPase-activating protein RICH2; rhoGAP interacting with CIP4 homologs protein 2", "tax_id": 10116, "disease": "lung carcinoma (Disease Ontology:DOID:3905); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:303222); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;23739967;25498153", "class_list": "", "function": "Expression increases during neuronal development, concurrent with a decrease in the rate of filopodia formation. Publication Status: Online-Only, [RefSeq, PubMed]; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:25498153). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:25498153). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (PubMed:25498153). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1LST2;M0RAT0", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0007165 signal transduction;GO:0032956 regulation of actin cytoskeleton organization;GO:0043087 regulation of GTPase activity;GO:0050804 modulation of chemical synaptic transmission;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1LQX4-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIF7-1", "uniprot_id": [ { "id": "SBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIF7", "type": "external" } ], "mass": 52532.0, "length": 472, "protein_name": "Methanethiol oxidase", "gene_name": "Selenbp1", "organism": "Rat", "refseq_name": "methanethiol oxidase", "refseq_ac": [ { "id": "NP_001316822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316822", "type": "external" } ], "gene_names_uniprotkb": "Selenbp1; Sbp", "gene_names_refseq": "MTO; Selenbp1; Selenbp2; rSBP", "protein_names_uniprotkb": "Methanethiol oxidase; 1.8.3.4; 56 kDa selenium-binding protein; MTO; SBP56; SP56; Selenium-binding protein 1; Selenium-binding protein 2", "protein_names_refseq": "56 kDa selenium-binding protein; SBP56; SP56; methanethiol oxidase; selenium-binding protein 2", "tax_id": 10116, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:103689947)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10799528;15352247;17377489;27578022;8701438", "class_list": "", "function": "Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; SBP1 may play a critical role in the pathological processes underlying chemical-induced nephrotoxicity; urinary excretion of SBP1 might be a sensitive and specific biomarker to detect early stages of kidney injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.4", "type": "external" } ], "go_molecular_function": "GO:0008430 selenium binding;GO:0018549 methanethiol oxidase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005634 nucleus", "go_biological_process": "GO:0015031 protein transport;GO:0050873 brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VIF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99N27-1", "uniprot_id": [ { "id": "SNX1_RAT", "url": "https://www.uniprot.org/uniprot/Q99N27", "type": "external" } ], "mass": 59044.0, "length": 522, "protein_name": "Sorting nexin-1", "gene_name": "Snx1", "organism": "Rat", "refseq_name": "sorting nexin-1", "refseq_ac": [ { "id": "NP_445863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445863", "type": "external" } ], "gene_names_uniprotkb": "Snx1; LOC102549158", "gene_names_refseq": "Snx1", "protein_names_uniprotkb": "Sorting nexin-1", "protein_names_refseq": "sorting nexin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:84471)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11110793;12198132;22673903;29393594", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity)., [UniProtKB, UniProtKB]; PX domain-dependent/early endosomal association of SNX1 is important for its ability to regulate the targeting of internalized epidermal growth factor receptor for lysosomal degradation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56A25", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0098999 extrinsic component of postsynaptic endosome membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0031175 neuron projection development;GO:0031623 receptor internalization;GO:0016197 endosomal transport;GO:0072673 lamellipodium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99N27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26453-1", "uniprot_id": [ { "id": "BASI_RAT", "url": "https://www.uniprot.org/uniprot/P26453", "type": "external" } ], "mass": 42436.0, "length": 388, "protein_name": "Basigin", "gene_name": "Bsg", "organism": "Rat", "refseq_name": "basigin isoform 1 precursor", "refseq_ac": [ { "id": "NP_001103352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103352", "type": "external" } ], "gene_names_uniprotkb": "Bsg", "gene_names_refseq": "5A11; Bsg; CE9; EMMPRIN; HT7; Ox47R; basignin", "protein_names_uniprotkb": "Basigin; Glycoprotein CE9; OX-47 antigen", "protein_names_refseq": "Basigin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); Basignin (Ox47 antigen or CE-9) (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian); OX-47 antigen; basigin (Ok blood group); basigin isoform 1 precursor; glycoprotein CE9; neurothelin", "tax_id": 10116, "disease": "3MC syndrome 3 (Disease Ontology:DOID:0060577); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); breast ductal carcinoma (Disease Ontology:DOID:3007); lung squamous cell carcinoma (Disease Ontology:DOID:3907); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); ovary serous adenocarcinoma (Disease Ontology:DOID:5744)", "pathway": " (rno:25246); (R-RNO-1474228); (R-RNO-210991); (R-RNO-216083); (R-RNO-433692); (R-RNO-9749641)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10921872;11719518;12141934;12939332;2009910;22673903;24090084;30446621;32594339;32908452;33138345;35257743;37700592;8425897", "class_list": "", "function": "CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and FLS in Collagen-Induced Arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (By similarity). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (By similarity)., [UniProtKB, UniProtKB]; Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors., [UniProtKB, UniProtKB]; Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-kappaB pathway in collagen-induced arthritis rats., [RefSeq, PubMed]; Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-Induced Bone Destruction and Pain., [RefSeq, PubMed]; Plays a role in neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis., [RefSeq, PubMed]; Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1 and SLC16A3 to the plasma membrane (PubMed:10921872). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; This study analyzed the direct interaction between CAIV and the two Monocarboxylate transporters (MCTs) chaperones basigin (CD147) and embigin (GP70). In rat CD147, binding of CAIV was mediated by by the positively charged Lys-73., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNP1", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005537 D-mannose binding;GO:0098632 cell-cell adhesion mediator activity;GO:0038023 signaling receptor activity;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904466 positive regulation of matrix metallopeptidase secretion;GO:0003407 neural retina development;GO:0007283 spermatogenesis;GO:0072659 protein localization to plasma membrane;GO:0010575 positive regulation of vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P26453-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIS1-1", "uniprot_id": [ { "id": "RIMS2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIS1", "type": "external" } ], "mass": 175913.0, "length": 1555, "protein_name": "Regulating synaptic membrane exocytosis protein 2", "gene_name": "Rims2", "organism": "Rat", "refseq_name": "regulating synaptic membrane exocytosis protein 2 isoform 2", "refseq_ac": [ { "id": "NP_665888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665888", "type": "external" } ], "gene_names_uniprotkb": "Rims2; Rim2", "gene_names_refseq": "Nim2; Rim2; Rims2", "protein_names_uniprotkb": "Regulating synaptic membrane exocytosis protein 2; RIM 2; Rab-3-interacting molecule 2", "protein_names_refseq": "RIM 2; rab-3-interacting molecule 2; rab3-interacting molecule 2; regulating synaptic membrane exocytosis protein 2 isoform 2; regulating synaptic membrane exocytosis protein 2-like; regulating synaptic membrane exocytosis protein 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:116839)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10748113;11797009;12620390;16052212;16641100;16732694;22673903;38843836", "class_list": "", "function": "Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIX2;Q9JHJ6;Q9JIR2;Q9JIR5;Q9JIR6;Q9JIR7;Q9JIR8;Q9JIR9;Q9JIS0", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0042734 presynaptic membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0006886 intracellular protein transport;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0042391 regulation of membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9JIS1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64568-1", "uniprot_id": [ { "id": "AT2B3_RAT", "url": "https://www.uniprot.org/uniprot/Q64568", "type": "external" } ], "mass": 138559.0, "length": 1258, "protein_name": "Plasma membrane calcium-transporting ATPase 3", "gene_name": "Atp2b3", "organism": "Rat", "refseq_name": "plasma membrane calcium-transporting ATPase 3 isoform 3", "refseq_ac": [ { "id": "NP_579822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579822", "type": "external" } ], "gene_names_uniprotkb": "Atp2b3; Pmca3", "gene_names_refseq": "Atp2b3; Pmca3", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 3; 7.2.2.10; PMCA3; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium pump isoform 3", "protein_names_refseq": "ATPase, Ca++ transporting, plasma membrane 3; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 3 isoform 3; plasma membrane calcium-transporting ATPase 3", "tax_id": 10116, "disease": "Hailey-Hailey disease (Disease Ontology:DOID:0050429); X-linked spinocerebellar ataxia 1 (Disease Ontology:DOID:0111829); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (rno:29599); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "1388171;17183553;22673903;25014339;2530223;27035656;28153703;31032369;8428948;9880546", "class_list": "", "function": "ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25014339, PubMed:9880546). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (PubMed:25014339, PubMed:9880546)., [UniProtKB, PubMed, PubMed]; Although modification of PMCAs composition could provide some protection against calcium overload, reduction of PMCA2 appeared to be more detrimental to the cells than deficiency of PMCA3. Under pathological conditions, including inflammatory CCL5 action and long-lasting Ca(2+) dyshomeostasis, insufficient cell protection may result in progressive degeneration and death of neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Higher occupancy of Calm2 and Calm3 promoters by NFATc2 and increased expression of these genes in response to NFATc2 silencing were demonstrated in PMCA2 and PMCA3-reduced lines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q01489;Q63444", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:1990032 parallel fiber", "go_biological_process": "GO:0003407 neural retina development;GO:0051480 regulation of cytosolic calcium ion concentration;GO:1990034 calcium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q64568-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47858-1", "uniprot_id": [ { "id": "PFKAM_RAT", "url": "https://www.uniprot.org/uniprot/P47858", "type": "external" } ], "mass": 85560.0, "length": 780, "protein_name": "ATP-dependent 6-phosphofructokinase, muscle type", "gene_name": "Pfkm", "organism": "Rat", "refseq_name": "ATP-dependent 6-phosphofructokinase, muscle type", "refseq_ac": [ { "id": "NP_113903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113903", "type": "external" } ], "gene_names_uniprotkb": "Pfkm; Pfk-m", "gene_names_refseq": "ATP-PFK; PFK-A; Pfk-M; Pfkm", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, muscle type; 2.7.1.11; 6-phosphofructokinase type A; ATP-PFK; PFK-A; PFK-M; Phosphofructo-1-kinase isozyme A; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase-A; phosphofructokinase-M; phosphohexokinase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); glycogen storage disease VII (Disease Ontology:DOID:11721); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:65152); (R-RNO-70171)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18683930;22673903;28545955;34502162;38843836;8764833", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; High phosphofructokinase expression is associated with glioma., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63736", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016208 AMP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0097228 sperm principal piece", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046716 muscle cell cellular homeostasis;GO:0042593 glucose homeostasis;GO:0001678 intracellular glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P47858-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYJ3-1", "uniprot_id": [ { "id": "SPA6L_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYJ3", "type": "external" } ], "mass": 46108.0, "length": 398, "protein_name": "Spermatogenesis associated 6-like protein", "gene_name": "Spata6l", "organism": "Rat", "refseq_name": "spermatogenesis associated 6-like protein", "refseq_ac": [ { "id": "NP_001014187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014187", "type": "external" } ], "gene_names_uniprotkb": "Spata6l", "gene_names_refseq": "RGD1310039; Spata6l", "protein_names_uniprotkb": "Spermatogenesis associated 6-like protein", "protein_names_refseq": "spermatogenesis associated 6-like protein; uncharacterized protein C9orf68 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361747)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032027 myosin light chain binding;GO:0052642 lysophosphatidic acid phosphatase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106405 isoprenoid diphosphate phosphatase activity", "go_cellular_component": "GO:0120212 sperm head-tail coupling apparatus;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0042632 cholesterol homeostasis;GO:0046839 phospholipid dephosphorylation;GO:1902565 positive regulation of neutrophil activation;GO:0033383 geranyl diphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2P4-1", "uniprot_id": [ { "id": "RGCC_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2P4", "type": "external" } ], "mass": 14766.0, "length": 137, "protein_name": "Regulator of cell cycle RGCC", "gene_name": "Rgccl1; Rgcc", "organism": "Rat", "refseq_name": "regulator of cell cycle RGCC", "refseq_ac": [ { "id": "NP_446460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446460", "type": "external" } ], "gene_names_uniprotkb": "Rgccl1; Rgcc; LOC683573; Rgc32; Rgccl1", "gene_names_refseq": "Rgc32; Rgcc", "protein_names_uniprotkb": "Regulator of cell cycle RGCC; RGC-32; Response gene to complement 32 protein", "protein_names_refseq": "RGC-32; regulator of cell cycle RGCC; response gene to complement 32 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:117183); (rno:683573)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21636805;22673903;28536621;29393594;9756947", "class_list": "", "function": "Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation (By similarity)., [UniProtKB, PubMed]; RGC-32 probably has an important impact on the repair process of renal tubular epithelial cells in vitro by regulating the G2/M phase checkpoint, cell fibrosis and cell adhesion. Publication Status: Online-Only, [RefSeq, PubMed]; Using a carotid artery balloon-injury model, we documented for the first time that neointima formation was closely associated with a significantly increased expression of RGC-32 protein., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0019887 protein kinase regulator activity;GO:0070412 R-SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0045931 positive regulation of mitotic cell cycle;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2P4-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63737-1", "uniprot_id": [ { "id": "PHLP_RAT", "url": "https://www.uniprot.org/uniprot/Q63737", "type": "external" } ], "mass": 34274.0, "length": 301, "protein_name": "Phosducin-like protein", "gene_name": "Pdcl", "organism": "Rat", "refseq_name": "phosducin-like protein", "refseq_ac": [ { "id": "NP_071583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071583", "type": "external" } ], "gene_names_uniprotkb": "Pdcl; AABR07051787.1", "gene_names_refseq": "Pdcl1; Pdcl; Phlp", "protein_names_uniprotkb": "Phosducin-like protein; PHLP", "protein_names_refseq": "phosducin-like 1; phosducin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64013); (R-RNO-6814122)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10095058;12060742;22673903;8248177;9139665", "class_list": "", "function": "Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Also acts as a positive regulator of hedgehog signaling and regulates ciliary function., [UniProtKB, UniProtKB]; Results suggest that the interaction between PhLP and complex polypeptide 1 (CCT) may be a means to regulate CCT-dependent protein folding or alternatively, to control the availability of PhLP to modulate G protein signaling, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8L9;Q63738", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007601 visual perception;GO:0006457 protein folding;GO:0030030 cell projection organization;GO:1902605 heterotrimeric G-protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63737-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70437-1", "uniprot_id": [ { "id": "SMAD4_RAT", "url": "https://www.uniprot.org/uniprot/O70437", "type": "external" } ], "mass": 60469.0, "length": 552, "protein_name": "SMAD family member 4", "gene_name": "Smad4", "organism": "Rat", "refseq_name": "SMAD family member 4", "refseq_ac": [ { "id": "NP_062148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062148", "type": "external" } ], "gene_names_uniprotkb": "Smad4; Madh4", "gene_names_refseq": "Madh4; Smad4", "protein_names_uniprotkb": "SMAD family member 4; MAD homolog 4; Mothers against DPP homolog 4; Mothers against decapentaplegic homolog 4; SMAD 4", "protein_names_refseq": "MAD (mothers against decapentaplegic Drosophila) homolog 4; MAD homolog 4; SMAD 4; SMAD family member 4; mothers against DPP homolog 4; mothers against decapentaplegic homolog 4", "tax_id": 10116, "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); colorectal adenoma (Disease Ontology:DOID:0050860); pre-malignant neoplasm (Disease Ontology:DOID:0060071); dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome (Disease Ontology:DOID:0111543); intestinal cancer (Disease Ontology:DOID:10155); urinary bladder cancer (Disease Ontology:DOID:11054); osteogenesis imperfecta (Disease Ontology:DOID:12347); hereditary hemorrhagic telangiectasia (Disease Ontology:DOID:1270); prostatitis (Disease Ontology:DOID:14654); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gastrointestinal system cancer (Disease Ontology:DOID:3119); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); Lynch syndrome (Disease Ontology:DOID:3883); cervical cancer (Disease Ontology:DOID:4362); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); aortic disease (Disease Ontology:DOID:520); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); prostate carcinoma in situ (Disease Ontology:DOID:8634); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:50554); (R-RNO-1181150); (R-RNO-1502540); (R-RNO-201451); (R-RNO-2173789); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-5689880); (R-RNO-8941855); (R-RNO-9617828)", "pathway_count": 10, "publication_count": 4, "publication_id_list": "10670756;16619037;31346987;34889563", "class_list": "", "function": "Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity)., [UniProtKB]; MiR-125b aggregates osteoporosis in postmenopausal rats via targeting Smad4., [RefSeq, PubMed]; The results showed that Bcl6 overexpression induced decreased proliferation and reduced activation of fibroblasts which were stimulated with TGFb1. It was found that activated smad2 and smad3 were not changed by overexpressing Bcl6, but smad4 was decreased., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003360 brainstem development;GO:0036302 atrioventricular canal development;GO:0071559 response to transforming growth factor beta;GO:0010631 epithelial cell migration;GO:0048729 tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70437-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59622-1", "uniprot_id": [ { "id": "SLAP1_RAT", "url": "https://www.uniprot.org/uniprot/P59622", "type": "external" } ], "mass": 34745.0, "length": 312, "protein_name": "Src-like-adapter", "gene_name": "Sla", "organism": "Rat", "refseq_name": "src-like-adapter", "refseq_ac": [ { "id": "NP_835198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835198", "type": "external" } ], "gene_names_uniprotkb": "Sla; Slap1; Slap", "gene_names_refseq": "Slap1; Sla", "protein_names_uniprotkb": "Src-like-adapter; SLAP-1; Src-like-adapter protein 1", "protein_names_refseq": "SLAP-1; src-like-adapter protein 1; src-like-adapter", "tax_id": 10116, "disease": "", "pathway": " (rno:338477)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0007165 signal transduction;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59622-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55016-1", "uniprot_id": [ { "id": "S12A1_RAT", "url": "https://www.uniprot.org/uniprot/P55016", "type": "external" } ], "mass": 120597.0, "length": 1095, "protein_name": "Solute carrier family 12 member 1", "gene_name": "Slc12a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc12a1; Nkcc2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 12 member 1; BSC1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Kidney-specific Na-K-Cl symporter; NKCC2; Na-K-2Cl cotransporter 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); Bartter disease type 1 (Disease Ontology:DOID:0110142); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); leiomyoma (Disease Ontology:DOID:127); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); severe acute respiratory syndrome (Disease Ontology:DOID:2945); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); Bartter disease (Disease Ontology:DOID:445); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (rno:25065); (R-RNO-426117)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "17341212;22673903;25967121;8021284", "class_list": "", "function": "Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (Probable) (PubMed:8021284). It can substitute NH4(+) for K(+), enabling NH4(+) apical transmembrane transport in the medullary thick ascending limb (MTAL). This function is crucial for maintaining ammonium homeostasis by the kidney, particularly during metabolic acidosis (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008511 sodium:potassium:chloride symporter activity;GO:0120283 protein serine/threonine kinase binding;GO:7770002 sodium:ammonium:chloride symporter activity", "go_cellular_component": "GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0071918 urea transmembrane transport;GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0001822 kidney development;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55016-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811V6-1", "uniprot_id": [ { "id": "SPAS1_RAT", "url": "https://www.uniprot.org/uniprot/Q811V6", "type": "external" } ], "mass": 31133.0, "length": 281, "protein_name": "Spermatogenesis-associated serine-rich protein 1", "gene_name": "Spats1", "organism": "Rat", "refseq_name": "spermatogenesis-associated serine-rich protein 1", "refseq_ac": [ { "id": "NP_852041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852041", "type": "external" } ], "gene_names_uniprotkb": "Spats1; Srsp1", "gene_names_refseq": "Spats1; Srsp1", "protein_names_uniprotkb": "Spermatogenesis-associated serine-rich protein 1; Spermatogenic serine-rich protein 1", "protein_names_refseq": "spermatogenesis-associated serine-rich protein 1; spermatogenic serine-rich protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:301255)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12826748;16641100;19948251", "class_list": "", "function": "Spats1 plays a role in the initiation of the first spermatogenic wave, and in the establishment or progression of the first male meiotic division., [RefSeq, PubMed]; The full length ORF encodes a putative phosphoprotein containing a serine stretch and a bipartite nuclear localization signal, which we call Srsp1 ('serin-rich spermatogenic protein 1')., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56A18-1", "uniprot_id": [ { "id": "SMCE1_RAT", "url": "https://www.uniprot.org/uniprot/Q56A18", "type": "external" } ], "mass": 42831.0, "length": 376, "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "gene_name": "Smarce1", "organism": "Rat", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform 2", "refseq_ac": [ { "id": "NP_001020164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020164", "type": "external" } ], "gene_names_uniprotkb": "Smarce1; Baf57", "gene_names_refseq": "BAF57; RGD1304726; Smarce1", "protein_names_uniprotkb": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; BAF57; BRG1-associated factor 57", "protein_names_refseq": "BRG1-associated factor 57; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1", "tax_id": 10116, "disease": "Coffin-Siris syndrome 5 (Disease Ontology:DOID:0112368); candidiasis (Disease Ontology:DOID:1508); meningioma (Disease Ontology:DOID:3565); familial meningioma (Disease Ontology:DOID:4586)", "pathway": " (rno:303518); (R-RNO-3214858); (R-RNO-8939243); (R-RNO-9933937); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9934037)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "19245665;22215678", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The N terminus of Brdt is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "C0IMX4;C0IMX5;C0IMX6;Q5BJV2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0016922 nuclear receptor binding;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0071565 nBAF complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045892 negative regulation of DNA-templated transcription;GO:0007286 spermatid development;GO:0006337 nucleosome disassembly;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q56A18-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJN8-1", "uniprot_id": [ { "id": "SDE2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJN8", "type": "external" } ], "mass": 48084.0, "length": 448, "protein_name": "UBL fusion protein SDE2", "gene_name": "Sde2", "organism": "Rat", "refseq_name": "UBL fusion protein SDE2", "refseq_ac": [ { "id": "NP_001020141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020141", "type": "external" } ], "gene_names_uniprotkb": "Sde2", "gene_names_refseq": "RGD1305572; Sde2", "protein_names_uniprotkb": "UBL fusion protein SDE2; Replication stress response regulator SDE2", "protein_names_refseq": "SDE2 telomere maintenance homolog; UBL fusion protein SDE2; UPF0667 protein C1orf55 homolog; protein SDE2 homolog; replication stress response regulator SDE2", "tax_id": 10116, "disease": "", "pathway": " (rno:289315); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (By similarity). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (By similarity). May recruit CACTIN to the spliceosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (By similarity). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0016485 protein processing;GO:0051301 cell division;GO:0006260 DNA replication;GO:0016567 protein ubiquitination;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05695-1", "uniprot_id": [ { "id": "L1CAM_RAT", "url": "https://www.uniprot.org/uniprot/Q05695", "type": "external" } ], "mass": 140935.0, "length": 1259, "protein_name": "Neural cell adhesion molecule L1", "gene_name": "L1cam", "organism": "Rat", "refseq_name": "neural cell adhesion molecule L1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_059041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059041", "type": "external" } ], "gene_names_uniprotkb": "L1cam; Caml1", "gene_names_refseq": "Hsas; Hyd; L1cam; N-CAM L1; NCAML1; NgCAM", "protein_names_uniprotkb": "Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; NILE; Nerve-growth factor-inducible large external glycoprotein", "protein_names_refseq": "N-CAM-L1; NCAM-L1; NILE; nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1 isoform 1 precursor; neural cell adhesion molecule L1; neuron-glia cell adhesion molecule", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); MASA syndrome (Disease Ontology:DOID:0060246); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); hypothyroidism (Disease Ontology:DOID:1459); depressive disorder (Disease Ontology:DOID:1596); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); glioblastoma (Disease Ontology:DOID:3068); bipolar disorder (Disease Ontology:DOID:3312); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); uterine cancer (Disease Ontology:DOID:363); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); schizophrenia (Disease Ontology:DOID:5419); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:50687); (R-RNO-210991); (R-RNO-373760); (R-RNO-437239); (R-RNO-445095); (R-RNO-445144)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10.1039/D0MO00044B;18519736;1894011;22673903;24090084;2466966;27027721;31426714;34106099;38728789;38843836;8592152;8663493", "class_list": "", "function": "L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection., [RefSeq, PubMed]; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth., [RefSeq, PubMed]; Toluene inhibits L1-lipid raft interactions at occupationally relevant concentrations and may lead to a fetal solvent spectrum disorder similar to fetal alcohol spectrum disorder, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 8, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 7, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 8, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 8, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 20, "disease_count": 17, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0044860 protein localization to plasma membrane raft;GO:0034109 homotypic cell-cell adhesion;GO:0097069 cellular response to thyroxine stimulus;GO:0098749 cerebellar neuron development", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "Q05695-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35412-1", "uniprot_id": [ { "id": "SI1L1_RAT", "url": "https://www.uniprot.org/uniprot/O35412", "type": "external" } ], "mass": 201925.0, "length": 1822, "protein_name": "Signal-induced proliferation-associated 1-like protein 1", "gene_name": "Sipa1l1", "organism": "Rat", "refseq_name": "signal-induced proliferation-associated 1-like protein 1 isoform 1", "refseq_ac": [ { "id": "NP_647546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647546", "type": "external" } ], "gene_names_uniprotkb": "Sipa1l1; Spa1", "gene_names_refseq": "SPAL; Sipa1l1; Spa-1; Spa1; Spar", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPA-1-like protein p1294; SPAR; Spine-associated Rap GTPase-activating protein", "protein_names_refseq": "SIPA1-like protein 1; SPA-1 like protein; SPA-1-like protein p1294; signal-induced proliferation-associated 1-like protein 1 isoform 1; signal-induced proliferation-associated 1-like protein 1; spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)", "tax_id": 10116, "disease": "", "pathway": " (rno:246212)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11502259;12059963;14576440;15196935;16522626;18094260;18498738;18723513;19900557;20146300;21382555;21987493;22673903;23850969;29180226", "class_list": "", "function": "Findings suggest that SPAL may be involved in the NMDA-mediated organization of cytoskeletal networks and signal transduction, [RefSeq, PubMed]; Long-term potentiation triggers downregulation of SPAR requiring ubiquitin proteasome system and NMDA receptor activation but not cyclin-dependent kinase (CDK)5., [RefSeq, PubMed]; Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats, [RefSeq, PubMed]; SPA-1 directly binds to AQP2 and regulates at least in part AQP2 trafficking, [RefSeq, PubMed]; Serum-inducible kinase bound to and phosphorylated spine-associated Rap guanosine triphosphatase activating protein (SPAR), a postsynaptic actin regulatory protein, leading to degradation of SPAR, [RefSeq, PubMed]; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis., [UniProtKB, PubMed]; The SNK-SPAR pathway may possibly play a crucial role in Amyloid beta-induced excitotoxic damage in the central nervous system by regulating synaptic stability., [RefSeq, PubMed]; The microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 40, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding;GO:0051015 actin filament binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0043087 regulation of GTPase activity;GO:0048013 ephrin receptor signaling pathway;GO:0048814 regulation of dendrite morphogenesis;GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O35412-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62876-1", "uniprot_id": [ { "id": "SNG1_RAT", "url": "https://www.uniprot.org/uniprot/Q62876", "type": "external" } ], "mass": 25669.0, "length": 234, "protein_name": "Synaptogyrin-1", "gene_name": "Syngr1", "organism": "Rat", "refseq_name": "synaptogyrin-1", "refseq_ac": [ { "id": "NP_062039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062039", "type": "external" } ], "gene_names_uniprotkb": "Syngr1", "gene_names_refseq": "Syngr1", "protein_names_uniprotkb": "Synaptogyrin-1; p29", "protein_names_refseq": "p29; synaptogyrin-1", "tax_id": 10116, "disease": "ptosis (Disease Ontology:DOID:0060260); lymphedema-distichiasis syndrome (Disease Ontology:DOID:0111509); nephritis (Disease Ontology:DOID:10952); lymphedema (Disease Ontology:DOID:4977); eyelid disease (Disease Ontology:DOID:530); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29205); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10383386;12928441;15590695;21454685;23636420;8557746", "class_list": "", "function": "Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment, [RefSeq, PubMed]; May play a role in regulated exocytosis (PubMed:10383386). Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (PubMed:12928441, PubMed:15590695). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Synaptogyrin-1 plays a regulatory role in transmission at the synapses of type III cells and is involved in exocytic function with synaptobrevin-2 in a subset of type II cells in rat taste buds., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0042470 melanosome;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0045055 regulated exocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0006605 protein targeting;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62876-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97690-1", "uniprot_id": [ { "id": "SMC3_RAT", "url": "https://www.uniprot.org/uniprot/P97690", "type": "external" } ], "mass": 138448.0, "length": 1191, "protein_name": "Structural maintenance of chromosomes protein 3", "gene_name": "Smc3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Smc3; Bam; Bmh; Cspg6; Smc3l1", "gene_names_refseq": "", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 3; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chondroitin sulfate proteoglycan 6; Chromosome segregation protein SmcD; SMC protein 3; SMC-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Cornelia de Lange syndrome 3 (Disease Ontology:DOID:0080507); intellectual disability (Disease Ontology:DOID:1059); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-RNO-2467813); (R-RNO-2468052); (R-RNO-2470946); (R-RNO-2500257); (R-RNO-3108214)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10652260;22673903;9015313", "class_list": "", "function": "Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0006275 regulation of DNA replication;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97690-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M824-1", "uniprot_id": [ { "id": "SHC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M824", "type": "external" } ], "mass": 51503.0, "length": 469, "protein_name": "SHC-transforming protein 1", "gene_name": "Shc1", "organism": "Rat", "refseq_name": "SHC-transforming protein 1 isoform b", "refseq_ac": [ { "id": "NP_445969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445969", "type": "external" } ], "gene_names_uniprotkb": "Shc1", "gene_names_refseq": "P66shc; Shc1", "protein_names_uniprotkb": "SHC-transforming protein 1; SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1", "protein_names_refseq": "SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1 isoform b; SHC-transforming protein 1; src homology 2 domain-containing-transforming protein C1", "tax_id": 10116, "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); familial hyperlipidemia (Disease Ontology:DOID:1168); hepatocellular carcinoma (Disease Ontology:DOID:684); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:85385); (R-RNO-1250196); (R-RNO-1250347); (R-RNO-167044); (R-RNO-180336); (R-RNO-201556); (R-RNO-210993); (R-RNO-2424491); (R-RNO-2428933); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-354192); (R-RNO-512988); (R-RNO-5654688); (R-RNO-5654699); (R-RNO-5654704); (R-RNO-5654719); (R-RNO-5673001); (R-RNO-74749); (R-RNO-74751); (R-RNO-8851805); (R-RNO-8853659); (R-RNO-8983432); (R-RNO-9009391); (R-RNO-9020558); (R-RNO-9027284); (R-RNO-912526); (R-RNO-9634597); (R-RNO-9674555); (R-RNO-9842663)", "pathway_count": 31, "publication_count": 10, "publication_id_list": "11694516;16186108;33628383;34063460;34087282;34714691;35278882;7544443;7675451;9582017", "class_list": "", "function": "Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension., [RefSeq, PubMed]; P66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat., [RefSeq, PubMed]; P66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli., [RefSeq, PubMed]; RXRalpha Blocks Nerve Regeneration after Spinal Cord Injury by Targeting p66shc. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0010008 endosome membrane;GO:0070435 Shc-EGFR complex", "go_biological_process": "GO:1990839 response to endothelin;GO:0001525 angiogenesis;GO:0006940 regulation of smooth muscle contraction;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5M824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71MB6-1", "uniprot_id": [ { "id": "SO4C1_RAT", "url": "https://www.uniprot.org/uniprot/Q71MB6", "type": "external" } ], "mass": 78648.0, "length": 724, "protein_name": "Solute carrier organic anion transporter family member 4C1", "gene_name": "Slco4c1", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 4C1", "refseq_ac": [ { "id": "NP_001002024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002024", "type": "external" } ], "gene_names_uniprotkb": "Slco4c1; Oatp4c1; Slc21a20", "gene_names_refseq": "Oatp-H; Oatp-M1; Oatp4c1; Slc21A20; Slco4c1", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 4C1; OATP4C1; Organic anion transporting polypeptide 4C1; SLCO4C1; Solute carrier family 21 member 20", "protein_names_refseq": "Organic anion transporter member 4C1; organic anion transporting polypeptide 4C1; solute carrier family 21 member 20; solute carrier organic anion transporter family member 4C1", "tax_id": 10116, "disease": "kidney failure (Disease Ontology:DOID:1074)", "pathway": " (rno:432363); (R-RNO-6798695); (R-RNO-879518)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "14993604;22673903;22768102", "class_list": "", "function": "Isolation, cloning, and activity in the transport pathway of digoxin in the kidney (Oatp4c1), [RefSeq, PubMed]; Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney. Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604, PubMed:22768102). Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:14993604, PubMed:22768102). The driving force for this transport activity is currently not known (PubMed:22768102). The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:14993604, PubMed:22768102). Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (PubMed:22768102). Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker). Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity). May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; These data definitively demonstrate the subcellular localization and histological location of Oatp4c1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q71MB6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHS2-1", "uniprot_id": [ { "id": "HIF3A_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHS2", "type": "external" } ], "mass": 72888.0, "length": 662, "protein_name": "Hypoxia-inducible factor 3-alpha", "gene_name": "Hif3a", "organism": "Rat", "refseq_name": "hypoxia-inducible factor 3-alpha isoform 1", "refseq_ac": [ { "id": "NP_071973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071973", "type": "external" } ], "gene_names_uniprotkb": "Hif3a", "gene_names_refseq": "Hif3a; Ipas; Mop7", "protein_names_uniprotkb": "Hypoxia-inducible factor 3-alpha; HIF-3-alpha; HIF3-alpha-1; HIF3-alpha", "protein_names_refseq": "HIF-3-alpha; HIF3-alpha-1; HIF3-alpha; Inhibitory PAS (Per/Arnt/Sim) domain protein; hypoxia inducible factor 3, alpha subunit; hypoxia inducible factor 3a; hypoxia-inducible factor 3-alpha isoform 1; hypoxia-inducible factor 3-alpha", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:64345); (R-RNO-1234158); (R-RNO-1234176); (R-RNO-8951664)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "11237857;12824304;16215633;29643458;29660430;33937412;35132534", "class_list": "", "function": "Acts as a transcriptional regulator in adaptive response to low oxygen tension. Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis. May act as a tumor suppressor., [UniProtKB, UniProtKB, UniProtKB]; HIF-1alpha, HIF-2alpha and HIF-3alpha may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension., [RefSeq, PubMed]; Hif3a RNA interference and HIF-prolyl hydroxylase inhibition protect cardiomyocytes against anoxia-reoxygenation injury via the HIF signaling pathway, [RefSeq, PubMed]; Hypoxia rapidly activates HIF-3alpha mRNA expression, [RefSeq, PubMed]; MiR-485-5p alleviates obstructive sleep apnea syndrome with hypertension by inhibiting PI3K/AKT signaling pathway via downregulating HIF3A expression., [RefSeq, PubMed]; MicroRNA-210-3p Promotes Chondrogenic Differentiation and Inhibits Adipogenic Differentiation Correlated with HIF-3alpha Signalling in Bone Marrow Mesenchymal Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Study in human mesenchymal stromal/stem cells revealed robust hypermethylation of histone H3 across HIF3A locus driven by pro-inflammatory cytokines. Experiments in a murine model of arteriotomy highlighted the activation of Hif3alpha expression in infiltrated inflammatory cells, suggesting a new role for Hif3alpha in inflammation in vivo. Erratum:[Sci Rep. 2020 Apr 17;10(1):6776. doi: 10.1038/s41598-020-62861-8. PMID: 32303693] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JHS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6T393-1", "uniprot_id": [ { "id": "SPT20_RAT", "url": "https://www.uniprot.org/uniprot/Q6T393", "type": "external" } ], "mass": 88191.0, "length": 789, "protein_name": "Spermatogenesis-associated protein 20", "gene_name": "Spata20", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 20", "refseq_ac": [ { "id": "NP_955434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955434", "type": "external" } ], "gene_names_uniprotkb": "Spata20", "gene_names_refseq": "Spata20; Ssp411", "protein_names_uniprotkb": "Spermatogenesis-associated protein 20; Sperm-specific protein 411; Ssp411", "protein_names_refseq": "sperm protein SSP411; sperm-specific protein 411; spermatogenesis-associated protein 20", "tax_id": 10116, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311)", "pathway": " (rno:360604)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15223837;22673903", "class_list": "", "function": "May play a role in fertility regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SSP411 may play a role in sperm maturation, fertilization, and/or embryo development, as has been shown in thioredoxin family, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6T393-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5JCS6-1", "uniprot_id": [ { "id": "SI1L2_RAT", "url": "https://www.uniprot.org/uniprot/Q5JCS6", "type": "external" } ], "mass": 189653.0, "length": 1722, "protein_name": "Signal-induced proliferation-associated 1-like protein 2", "gene_name": "Sipa1l2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sipa1l2; Sersap2", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2; Serine-rich synapse-associated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361442)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098793 presynapse;GO:0099092 postsynaptic density, intracellular component", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0098928 presynaptic signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5JCS6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99M63-1", "uniprot_id": [ { "id": "SMU1_RAT", "url": "https://www.uniprot.org/uniprot/Q99M63", "type": "external" } ], "mass": 57551.0, "length": 513, "protein_name": "WD40 repeat-containing protein SMU1", "gene_name": "Smu1", "organism": "Rat", "refseq_name": "WD40 repeat-containing protein SMU1", "refseq_ac": [ { "id": "NP_476543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476543", "type": "external" } ], "gene_names_uniprotkb": "Smu1; Bwd", "gene_names_refseq": "Bwd; Smu-1; Smu1", "protein_names_uniprotkb": "WD40 repeat-containing protein SMU1; Brain-enriched WD repeat-containing protein; Smu-1 suppressor of mec-8 and unc-52 protein homolog", "protein_names_refseq": "DNA replication regulator and spliceosomal factor; WD40 repeat-containing protein SMU1; brain-enriched WD repeat-containing protein; brain-enriched WD-repeat protein; homolog of C. elegans smu-1; smu-1 suppressor of mec-8 and unc-52 homolog; smu-1 suppressor of mec-8 and unc-52 protein homolog; suppressor of Mec and Unc defects 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:117541)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11410362", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Involved in pre-mRNA splicing as a component of the spliceosome. Regulates alternative splicing of the HSPG2 pre-mRNA. Required for normal accumulation of IK. Required for normal mitotic spindle assembly and normal progress through mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071011 precatalytic spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99M63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08815-1", "uniprot_id": [ { "id": "SLK_RAT", "url": "https://www.uniprot.org/uniprot/O08815", "type": "external" } ], "mass": 137888.0, "length": 1206, "protein_name": "STE20-like serine/threonine-protein kinase", "gene_name": "Slk", "organism": "Rat", "refseq_name": "STE20-like serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_062222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062222", "type": "external" } ], "gene_names_uniprotkb": "Slk; Sk2", "gene_names_refseq": "SK2; Slk; Stk2", "protein_names_uniprotkb": "STE20-like serine/threonine-protein kinase; 2.7.11.1; STE20-like kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase", "protein_names_refseq": "STE20-like serine/threonine-protein kinase; STE20-related kinase; STE20-related serine/threonine-protein kinase; serine/threonine kinase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:54308); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12965890;16316999;2062320;22673903;28475647;29054447", "class_list": "", "function": "Mediates apoptosis and actin stress fiber dissolution., [UniProtKB]; SLK is an anoxia/recovery-dependent kinase that is activated via homodimerization and that signals via ASK1 and p38 to promote apoptosis, [RefSeq, PubMed]; Stk2 is a renal epithelial protein kinase whose expression and activity are increased during development and recovery from acute renal failure (germinal center kinase SK2), [RefSeq, PubMed]; Study found that the phosphorylation level of Mammalian STE20-like kinase-1 (Mst1) in injured area was significantly increased after traumatic brain injury (TBI) in rat model of TBI., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031252 cell leading edge;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08815-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70615-1", "uniprot_id": [ { "id": "LMNB1_RAT", "url": "https://www.uniprot.org/uniprot/P70615", "type": "external" } ], "mass": 66606.0, "length": 587, "protein_name": "Lamin-B1", "gene_name": "Lmnb1", "organism": "Rat", "refseq_name": "lamin-B1", "refseq_ac": [ { "id": "NP_446357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446357", "type": "external" } ], "gene_names_uniprotkb": "Lmnb1", "gene_names_refseq": "Lmnb1", "protein_names_uniprotkb": "Lamin-B1", "protein_names_refseq": "lamin-B1", "tax_id": 10116, "disease": "congenital muscular dystrophy (Disease Ontology:DOID:0050557); autosomal dominant primary microcephaly 26 (Disease Ontology:DOID:0051037); typical adult-onset autosomal dominant demyelinating leukodystrophy (Disease Ontology:DOID:0060785); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:116685); (R-RNO-2559584); (R-RNO-2980766); (R-RNO-2995383); (R-RNO-352238); (R-RNO-4419969); (R-RNO-9035034)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "16128803;22673903;30924780;33300615", "class_list": "", "function": "Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis., [RefSeq, PubMed]; Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The current research provided direct evidence that LaminB1 was expressed in the developing cochlea and developmentally regulated in cochlear tissues, suggesting a possible role of LaminB1 in cochlear development. the result provided a theoretical basis for further study about the physiological function of LaminB1 in the peripheral auditory system., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0003690 double-stranded DNA binding;GO:0043274 phospholipase binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0160123 structural constituent of nuclear lamina", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0016363 nuclear matrix", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0009410 response to xenobiotic stimulus;GO:0006998 nuclear envelope organization;GO:0022008 neurogenesis;GO:0071386 cellular response to corticosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P70615-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55034-1", "uniprot_id": [ { "id": "SPAG4_RAT", "url": "https://www.uniprot.org/uniprot/O55034", "type": "external" } ], "mass": 48693.0, "length": 444, "protein_name": "Sperm-associated antigen 4 protein", "gene_name": "Spag4", "organism": "Rat", "refseq_name": "sperm-associated antigen 4 protein", "refseq_ac": [ { "id": "NP_113980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113980", "type": "external" } ], "gene_names_uniprotkb": "Spag4; Sun4", "gene_names_refseq": "Spag4", "protein_names_uniprotkb": "Sperm-associated antigen 4 protein; Outer dense fiber-associated protein SPAG4; SUN domain-containing protein 4", "protein_names_refseq": "SUN domain-containing protein 4; outer dense fiber-associated protein SPAG4; sperm antigen 4; sperm-associated antigen 4 protein-like; sperm-associated antigen 4 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:83623)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10373309;22673903", "class_list": "", "function": "Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity (By similarity). May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail (PubMed:10373309)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005874 microtubule;GO:0005637 nuclear inner membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55034-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54980-1", "uniprot_id": [ { "id": "SNG2_RAT", "url": "https://www.uniprot.org/uniprot/O54980", "type": "external" } ], "mass": 24711.0, "length": 224, "protein_name": "Synaptogyrin-2", "gene_name": "Syngr2", "organism": "Rat", "refseq_name": "synaptogyrin-2", "refseq_ac": [ { "id": "NP_446005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446005", "type": "external" } ], "gene_names_uniprotkb": "Syngr2", "gene_names_refseq": "Syngr2", "protein_names_uniprotkb": "Synaptogyrin-2; Cellugyrin", "protein_names_refseq": "cellugyrin; synaptogyrin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:89815)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10383386;10967091;12928441;15590695;26071524;9446595", "class_list": "", "function": "Cellugyrin and synaptogyrin have roles in facilitating targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment, [RefSeq, PubMed]; May play a role in regulated exocytosis (PubMed:10383386). In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles (PubMed:12928441, PubMed:15590695). May also play a role in GLUT4 storage and transport to the plasma membrane (PubMed:26071524)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Small conserved hydrophobic hairpins in the first luminal loop and the carboxyl terminus of cellugyrin were found to be critical for the formation of SLMVs, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0006605 protein targeting;GO:0048499 synaptic vesicle membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54980-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08651-1", "uniprot_id": [ { "id": "SERA_RAT", "url": "https://www.uniprot.org/uniprot/O08651", "type": "external" } ], "mass": 56493.0, "length": 533, "protein_name": "D-3-phosphoglycerate dehydrogenase", "gene_name": "Phgdh", "organism": "Rat", "refseq_name": "D-3-phosphoglycerate dehydrogenase", "refseq_ac": [ { "id": "NP_113808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113808", "type": "external" } ], "gene_names_uniprotkb": "Phgdh", "gene_names_refseq": "Phgdh", "protein_names_uniprotkb": "D-3-phosphoglycerate dehydrogenase; 1.1.1.95; 3-PGDH", "protein_names_refseq": "3-PGDH; 3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase", "tax_id": 10116, "disease": "PHGDH deficiency (Disease Ontology:DOID:0050722); Neu-Laxova syndrome 1 (Disease Ontology:DOID:0080076); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:58835); (R-RNO-977347)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "18683930;29393594;33846783;9163325", "class_list": "", "function": "Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Phgdh serves a protective role in Il1beta induced chondrocyte inflammation and oxidativestress damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546Q9", "ec_number_list": [ { "id": "1.1.1.95", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.95", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0004617 phosphoglycerate dehydrogenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0021782 glial cell development;GO:0021510 spinal cord development;GO:0031175 neuron projection development;GO:0021915 neural tube development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O08651-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35314-1", "uniprot_id": [ { "id": "SCG1_RAT", "url": "https://www.uniprot.org/uniprot/O35314", "type": "external" } ], "mass": 77536.0, "length": 675, "protein_name": "Secretogranin-1", "gene_name": "Chgb", "organism": "Rat", "refseq_name": "secretogranin-1 precursor", "refseq_ac": [ { "id": "NP_036658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036658", "type": "external" } ], "gene_names_uniprotkb": "Chgb", "gene_names_refseq": "Chgb", "protein_names_uniprotkb": "Secretogranin-1; CgB; Chromogranin-B; Glucagonoma peptide; Secretogranin-I; SgI", "protein_names_refseq": "Chromogranin B, parathyroid secretory protein; cgB; chromogranin B (secretogranin 1); glucagonoma peptide; secretogranin-1 precursor; secretogranin-1; secretogranin-I; sgI", "tax_id": 10116, "disease": "", "pathway": " (rno:24259); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11854265;12902350;18181560;18420944;18437352;1954895;22673903;24266713;25217033;2641278;31182646;3608978", "class_list": "", "function": "CGB is a novel regulator of cardiomyocyte InsP(3)/Ca(2+)-dependent signaling, nuclear factor kappaB activity, and brain natriuretic peptide production, [RefSeq, PubMed]; CGB was localized in the nucleus; transcription control role of CGB in the nucleus, [RefSeq, PubMed]; CgB is necessary for efficient trafficking of secretory proteins into the budding granule, which impacts the availability of insulin-containing secretory granules for exocytic release. Publication Status: Online-Only, [RefSeq, PubMed]; Chromogranin B has a role in secretory granule biogenesis, [RefSeq, PubMed]; Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation. Publication Status: Online-Only, [RefSeq, PubMed]; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides., [UniProtKB]; Stimulation with a secretagogue mixture induced parallel release of insulin and chromogranin B from pancreatic beta cells., [RefSeq, PubMed]; When released extra-cellulary, CHGB proteolytic fragments exert a feedback effect to inhibit catecholamine secretion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N9;Q9QVG8;Q9QVH1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O35314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70593-1", "uniprot_id": [ { "id": "SGTA_RAT", "url": "https://www.uniprot.org/uniprot/O70593", "type": "external" } ], "mass": 34157.0, "length": 314, "protein_name": "Small glutamine-rich tetratricopeptide repeat-containing protein alpha", "gene_name": "Sgta", "organism": "Rat", "refseq_name": "small glutamine-rich tetratricopeptide repeat-containing protein alpha", "refseq_ac": [ { "id": "NP_073194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073194", "type": "external" } ], "gene_names_uniprotkb": "Sgta; Sgt1; Sgt; Stg", "gene_names_refseq": "Sgta; Stg", "protein_names_uniprotkb": "Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT; Small glutamine-rich protein with tetratricopeptide repeats 1", "protein_names_refseq": "alpha-SGT; small glutamine rich tetratricopeptide repeat containing alpha; small glutamine-rich protein with tetratricopeptide repeats 1; small glutamine-rich tetratricopeptide repeat (TPR) containing protein (SGT); small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; small glutamine-rich tetratricopeptide repeat-containing protein alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:64667); (R-RNO-9609523)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12878599;15708368;16641100;22673903;25030242;9557704", "class_list": "", "function": "Brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein, [RefSeq, PubMed]; Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (By similarity). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:12878599)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SGTA is involved in biochemical and physiological responses after spinal cord injury., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q548F5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:1904288 BAT3 complex binding", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70593-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02634-1", "uniprot_id": [ { "id": "S100G_RAT", "url": "https://www.uniprot.org/uniprot/P02634", "type": "external" } ], "mass": 9038.0, "length": 79, "protein_name": "Protein S100-G", "gene_name": "S100g", "organism": "Rat", "refseq_name": "protein S100-G", "refseq_ac": [ { "id": "NP_036653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036653", "type": "external" } ], "gene_names_uniprotkb": "S100g; Calb3; S100d", "gene_names_refseq": "Cabp; Calb3; Cbpi; Rncalbd9; S100g", "protein_names_uniprotkb": "Protein S100-G; 9 kDa CaBP; CABP; Calbindin-D9k; Cholecalcin; S100 calcium-binding protein G; Vitamin D-dependent calcium-binding protein, intestinal", "protein_names_refseq": "9 kDa CaBP; calbindin 3, (vitamin D-dependent calcium binding protein); calbindin-D9K; calcium-binding protein, intestinal, vitamin D-dependent (9-kDa CaBP); cholecalcin; protein S100-G; vitamin D-dependent calcium-binding protein, intestinal", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714)", "pathway": " (rno:24249)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "21605449;22673903;25674214;3194402;3345761;3476932;3741407;6315698;7750504", "class_list": "", "function": "Estrogen-induced CaBP-9k directly combines with ERalpha, suggesting that CaBP-9k is involved in the biological effects mediated by an ER pathway in the GH3 rat pituitary prolactinoma cell line Publication Status: Online-Only, [RefSeq, PubMed]; S100 g is a functional component of E2 genomic effect that accelerates egg transport. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51964", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005499 vitamin D binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P02634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M869-1", "uniprot_id": [ { "id": "SIT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M869", "type": "external" } ], "mass": 19368.0, "length": 178, "protein_name": "Signaling threshold-regulating transmembrane adapter 1", "gene_name": "Sit1", "organism": "Rat", "refseq_name": "signaling threshold-regulating transmembrane adapter 1", "refseq_ac": [ { "id": "NP_001019515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019515", "type": "external" } ], "gene_names_uniprotkb": "Sit1; Sit", "gene_names_refseq": "Sit1", "protein_names_uniprotkb": "Signaling threshold-regulating transmembrane adapter 1; SHP2-interacting transmembrane adapter protein; Suppression-inducing transmembrane adapter 1", "protein_names_refseq": "SHP2-interacting transmembrane adapter protein; signaling threshold-regulating transmembrane adapter 1; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1", "tax_id": 10116, "disease": "", "pathway": " (rno:500449)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16160011;22673903", "class_list": "", "function": "Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019900 kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0002250 adaptive immune response;GO:0043029 T cell homeostasis;GO:0050863 regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M869-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9G6-1", "uniprot_id": [ { "id": "SNIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9G6", "type": "external" } ], "mass": 44923.0, "length": 389, "protein_name": "Smad nuclear interacting protein 1", "gene_name": "Snip1", "organism": "Rat", "refseq_name": "smad nuclear interacting protein 1", "refseq_ac": [ { "id": "NP_001014091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014091", "type": "external" } ], "gene_names_uniprotkb": "Snip1", "gene_names_refseq": "Snip1", "protein_names_uniprotkb": "Smad nuclear interacting protein 1", "protein_names_refseq": "smad nuclear interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:313588); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0035196 miRNA processing;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M9G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63553-1", "uniprot_id": [ { "id": "SNRK_RAT", "url": "https://www.uniprot.org/uniprot/Q63553", "type": "external" } ], "mass": 81627.0, "length": 746, "protein_name": "SNF-related serine/threonine-protein kinase", "gene_name": "Snrk", "organism": "Rat", "refseq_name": "SNF-related serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_620188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620188", "type": "external" } ], "gene_names_uniprotkb": "Snrk", "gene_names_refseq": "Snrk", "protein_names_uniprotkb": "SNF-related serine/threonine-protein kinase; 2.7.11.1; SNF1-related kinase", "protein_names_refseq": "SNF-related serine/threonine-protein kinase; SNF1-related kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:170837)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10930554;22673903;34621049;8654423", "class_list": "", "function": "May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis., [UniProtKB, PubMed, PubMed, UniProtKB]; Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0043523 regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63553-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXV6-1", "uniprot_id": [ { "id": "CBY2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXV6", "type": "external" } ], "mass": 52009.0, "length": 447, "protein_name": "Protein chibby homolog 2", "gene_name": "Cby2", "organism": "Rat", "refseq_name": "protein chibby homolog 2", "refseq_ac": [ { "id": "NP_001017506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017506", "type": "external" } ], "gene_names_uniprotkb": "Cby2; Spert", "gene_names_refseq": "Cby2; Spert", "protein_names_uniprotkb": "Protein chibby homolog 2; Spermatid-associated protein", "protein_names_refseq": "protein chibby homolog 2; spermatid associated; spermatid-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:498572)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0031410 cytoplasmic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1U5-1", "uniprot_id": [ { "id": "SIK1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1U5", "type": "external" } ], "mass": 84909.0, "length": 776, "protein_name": "Serine/threonine-protein kinase SIK1", "gene_name": "Sik1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase SIK1", "refseq_ac": [ { "id": "NP_067725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067725", "type": "external" } ], "gene_names_uniprotkb": "Sik1; Kid2; Sik; Snf1lk", "gene_names_refseq": "Sik1; Sik; Snf1lk", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK1; 2.7.11.1; Protein kinase KID2; SIK-1; Salt-inducible kinase 1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK", "protein_names_refseq": "SIK-1; SNF1-like kinase; protein kinase KID2; salt-inducible protein kinase 1; serine/threonine-protein kinase SIK1; serine/threonine-protein kinase SNF1-like kinase 1; serine/threonine-protein kinase SNF1LK", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 30 (Disease Ontology:DOID:0080465)", "pathway": " (rno:59329)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10403390;10820182;12530631;17939993;18946175;19244510;21954104;23349925;23670276;26210066;26567857;29393594;31233505;32106109", "class_list": "", "function": "Nucleocytoplasmic shuttling of SIK may play important role in transcriptional regulation of cAMP-responsive element (CRE)-dependent gene expression., [RefSeq, PubMed]; Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization., [RefSeq, PubMed]; Role for SIK1 in the positive regulation of selective HDL-CE transport function of SR-B1 and steroidogenesis, [RefSeq, PubMed]; SIK1 plays a crucial role in the regulation of glucose and lipid metabolism in the livers of HFD/STZ-induced T2DM rats, where it suppresses hepatic gluconeogenesis and lipogenesis by regulating the SIK1/CRTC2 and SIK1/SREBP-1c signalling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R081", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010830 regulation of myotube differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R1U5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUB5-1", "uniprot_id": [ { "id": "NCOR1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUB5", "type": "external" } ], "mass": 57795.0, "length": 533, "protein_name": "Nuclear receptor corepressor 1", "gene_name": "Ncor1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncor1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear receptor corepressor 1; N-CoR1; N-CoR", "protein_names_refseq": "", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); anxiety disorder (Disease Ontology:DOID:2030)", "pathway": " (rno:54299)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10441327;10491148;16641100;22673903", "class_list": "", "function": "Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70463", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0002155 regulation of thyroid hormone receptor signaling pathway;GO:0060318 definitive erythrocyte differentiation;GO:0045922 negative regulation of fatty acid metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WUB5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK66-1", "uniprot_id": [ { "id": "PRKN_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK66", "type": "external" } ], "mass": 51709.0, "length": 465, "protein_name": "E3 ubiquitin-protein ligase parkin", "gene_name": "Prkn", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase parkin", "refseq_ac": [ { "id": "NP_064478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064478", "type": "external" } ], "gene_names_uniprotkb": "Prkn; AABR07001519.1; Park2", "gene_names_refseq": "Park2; Park; Prkn", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase parkin; 2.3.2.31; Parkin RBR E3 ubiquitin-protein ligase", "protein_names_refseq": "E3 ubiquitin-protein ligase parkin; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; parkinson protein 2, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); cardiomyopathy (Disease Ontology:DOID:0050700); Parkinson's disease 2 (Disease Ontology:DOID:0060368); Parkinson's disease 6 (Disease Ontology:DOID:0060369); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); cervical cancer (Disease Ontology:DOID:4362); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:56816); (R-RNO-5205685); (R-RNO-5675482); (R-RNO-5689877); (R-RNO-9646399); (R-RNO-983168)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "10686358;10737637;12925569;16955485;23661642;36647045;37715413;38393524;38788061;39097918;39267792", "class_list": "", "function": "Activation of Pink1/Parkin-mediated mitochondrial autophagy alleviates exertional heat stroke-induced acute lung injury in rats., [RefSeq, PubMed]; Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis., [RefSeq, PubMed]; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway., [RefSeq, PubMed]; Parkin plays a crucial role in acute viral myocarditis by regulating mitophagy activity. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Parkin in Rat Pancreatic Beta Cells Fate. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5C3;Q8K5C4;Q8K5C5;Q8K5C6;Q8VHY6;Q9JLL1;Q9JM64", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0097708 intracellular vesicle;GO:0099073 mitochondrion-derived vesicle;GO:0000139 Golgi membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903861 positive regulation of dendrite extension;GO:0010636 positive regulation of mitochondrial fusion;GO:2001171 positive regulation of ATP biosynthetic process;GO:0001964 startle response", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9JK66-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R064-1", "uniprot_id": [ { "id": "GORS2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R064", "type": "external" } ], "mass": 47221.0, "length": 454, "protein_name": "Golgi reassembly-stacking protein 2", "gene_name": "Gorasp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gorasp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 2; GRASP55; GRS2; Golgi reassembly-stacking protein of 55 kDa", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:113961); (R-RNO-162658)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10487747;11739401;11739402;15047867;15340146;17496889;18683930;20657584;23940043;29689198", "class_list": "", "function": "Key structural protein of the Golgi apparatus (By similarity). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (By similarity). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (By similarity). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:23940043). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007030 Golgi organization;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9R064-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64578-1", "uniprot_id": [ { "id": "AT2A1_RAT", "url": "https://www.uniprot.org/uniprot/Q64578", "type": "external" } ], "mass": 109409.0, "length": 994, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "gene_name": "AABR07005775.1; Atp2a1", "organism": "Rat", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "refseq_ac": [ { "id": "NP_478120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_478120", "type": "external" } ], "gene_names_uniprotkb": "AABR07005775.1; Atp2a1; AABR07005775.1; Atp2a1", "gene_names_refseq": "Atp2a1; Serca1", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA1; SR Ca(2+)-ATPase 1", "protein_names_refseq": "ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic reticulum calcium ATPase 1a; sarco/endoplasmic reticulum calcium ATPase 1b; sarco/endoplasmic reticulum calcium ATPase 1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "tax_id": 10116, "disease": "Brody myopathy (Disease Ontology:DOID:0050692); heart disease (Disease Ontology:DOID:114); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116601); (R-RNO-418359); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10329971;22673903;28765908;8447366", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In acute stages of sepsis, the improvement of SERCA function could reduce the disequilibrium of calcium homeostasis to improve the critical illness myopathy and respiratory failure., [RefSeq, PubMed]; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0051659 maintenance of mitochondrion location;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q64578-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63358-1", "uniprot_id": [ { "id": "MYO9B_RAT", "url": "https://www.uniprot.org/uniprot/Q63358", "type": "external" } ], "mass": 225037.0, "length": 1980, "protein_name": "Unconventional myosin-IXb", "gene_name": "Myo9b", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myo9b; Myr5", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-IXb; Unconventional myosin-9b", "protein_names_refseq": "", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); nephrotic syndrome (Disease Ontology:DOID:1184); dilated cardiomyopathy (Disease Ontology:DOID:12930); acute kidney failure (Disease Ontology:DOID:3021); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); double outlet right ventricle (Disease Ontology:DOID:6406); pulmonary hypertension (Disease Ontology:DOID:6432); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (R-RNO-2029482); (R-RNO-8980692); (R-RNO-8985586); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9035034)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "22673903;38843836;7882973;9819351", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA (PubMed:7882973). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 25, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098871 postsynaptic actin cytoskeleton;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005938 cell cortex", "go_biological_process": "GO:0043547 positive regulation of GTPase activity;GO:0007266 Rho protein signal transduction;GO:0030048 actin filament-based movement;GO:0035023 regulation of Rho protein signal transduction;GO:0072673 lamellipodium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63358-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62696-1", "uniprot_id": [ { "id": "DLG1_RAT", "url": "https://www.uniprot.org/uniprot/Q62696", "type": "external" } ], "mass": 100571.0, "length": 911, "protein_name": "Disks large homolog 1", "gene_name": "Dlg1", "organism": "Rat", "refseq_name": "disks large homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_036920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036920", "type": "external" } ], "gene_names_uniprotkb": "Dlg1; Dlgh1", "gene_names_refseq": "Dlg1; Dlgh1; SAP97", "protein_names_uniprotkb": "Disks large homolog 1; SAP-97; SAP97; Synapse-associated protein 97", "protein_names_refseq": "Drosophila discs-large tumor suppressor homologue (synapse associated protein); discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; disks large homolog 1 isoform 1; disks large homolog 1; synapse-associated protein 97", "tax_id": 10116, "disease": "immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); developmental disorder of mental health (Disease Ontology:DOID:0060037); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); alcohol-associated liver disease (Disease Ontology:DOID:0070658); lupus nephritis (Disease Ontology:DOID:0080162); latent autoimmune diabetes in adults (Disease Ontology:DOID:0080846); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); silicosis (Disease Ontology:DOID:10325); celiac disease (Disease Ontology:DOID:10608); anogenital venereal wart (Disease Ontology:DOID:11168); sarcoidosis (Disease Ontology:DOID:11335); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); malaria (Disease Ontology:DOID:12365); hepatitis A (Disease Ontology:DOID:12549); Sjogren's syndrome (Disease Ontology:DOID:12894); Behcet's disease (Disease Ontology:DOID:13241); urinary schistosomiasis (Disease Ontology:DOID:1394); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune hemolytic anemia (Disease Ontology:DOID:718); autoimmune thyroiditis (Disease Ontology:DOID:7188); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); psoriasis (Disease Ontology:DOID:8893); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); iridocyclitis (Disease Ontology:DOID:9383); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:25252); (R-RNO-399719); (R-RNO-438066); (R-RNO-451308); (R-RNO-5673001); (R-RNO-8849932)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "10629225;11865057;12933808;14597197;14960569;15044483;15504326;15951562;16495444;16630835;17980554;19118189;19213956;21119615;22673903;30067285;35039052;35145085;38461868;7891172;9115257;9677374;9786987", "class_list": "", "function": "Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Spinal nerve transection-induced upregulation of SAP97 via promoting membrane trafficking of GluA1-containing AMPA receptors in the dorsal horn contributes to the pathogenesis of neuropathic pain., [RefSeq, PubMed]; The SF3B1(R625H) mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1. Publication Status: Online-Only, [RefSeq, PubMed]; This study reveals plasticity in surface NMDAR localization driven by mutant HTT and identifies the similar but independent roles of SAP97 N-terminal isoforms in maintaining normal synaptic function in pathological states., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 57, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035748 myelin sheath abaxonal region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0031579 membrane raft organization;GO:0030432 peristalsis;GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0048729 tissue morphogenesis;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q62696-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26433-1", "uniprot_id": [ { "id": "SL9A3_RAT", "url": "https://www.uniprot.org/uniprot/P26433", "type": "external" } ], "mass": 93133.0, "length": 831, "protein_name": "Sodium/hydrogen exchanger 3", "gene_name": "Slc9a3", "organism": "Rat", "refseq_name": "sodium/hydrogen exchanger 3 precursor", "refseq_ac": [ { "id": "NP_001400969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001400969", "type": "external" } ], "gene_names_uniprotkb": "Slc9a3; Nhe3", "gene_names_refseq": "Nhe3; Slc9a3", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 3; NHE-3; Na(+)/H(+) exchanger 3; Solute carrier family 9 member 3", "protein_names_refseq": "NHE-3; Na(+)/H(+) exchanger 3; Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive); plasma membrane ion transport protein; sodium/hydrogen exchanger 3 precursor; sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; solute carrier family 9 member 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3", "tax_id": 10116, "disease": "sleep apnea (Disease Ontology:DOID:0050847); left ventricular failure (Disease Ontology:DOID:0051064); congenital secretory sodium diarrhea 8 (Disease Ontology:DOID:0060777); hypertension (Disease Ontology:DOID:10763); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); malignant renovascular hypertension (Disease Ontology:DOID:13730); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); androgen insensitivity syndrome (Disease Ontology:DOID:4674); nephrolithiasis (Disease Ontology:DOID:585); gastrointestinal system disease (Disease Ontology:DOID:77); chronic kidney disease (Disease Ontology:DOID:784); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24784); (R-RNO-425986)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "12576672;15687252;1577762;16293618;17409282;18653479;20015946;20584908;20630932;22031782;22673903;24666699;25656367;27510906;28126464;28490531;29537313;32755467;33476711;35076190;8393860;9442041;9933588", "class_list": "", "function": "Computational model of the renal circadian clock predicting effect of circadian clock modulation of NHE3 on proximal tubule cell on sodium transport., [RefSeq, PubMed]; In spontaneously hypertensive rats, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated the hypertension caused by the high plasma level of ANG II., [RefSeq, PubMed]; MOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity., [RefSeq, PubMed]; Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (PubMed:8393860, PubMed:9442041). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results show that renal afferents leads to activation of catecholaminergic and non-catecholaminergic neurons in the medulla oblongata. When renorenal reflex is induced, NHE3 exchanger activity appears to be decreased, resulting in decreased sodium and water reabsorption in the contralateral kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0051384 response to glucocorticoid;GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis;GO:0007623 circadian rhythm;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P26433-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97839-1", "uniprot_id": [ { "id": "DLGP4_RAT", "url": "https://www.uniprot.org/uniprot/P97839", "type": "external" } ], "mass": 108035.0, "length": 992, "protein_name": "Disks large-associated protein 4", "gene_name": "Dlgap4", "organism": "Rat", "refseq_name": "disks large-associated protein 4 isoform 1", "refseq_ac": [ { "id": "NP_775168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775168", "type": "external" } ], "gene_names_uniprotkb": "Dlgap4; Dap4; Sapap4", "gene_names_refseq": "DAP-4; Dap4; Dlgap4; SAPAP4", "protein_names_uniprotkb": "Disks large-associated protein 4; DAP-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4", "protein_names_refseq": "PSD-95/SAP90-associated protein-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4; discs, large homolog-associated protein 4; disks large-associated protein 4 isoform 1; disks large-associated protein 4", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:286930); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;9115257", "class_list": "", "function": "May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0090128 regulation of synapse maturation;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97839-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06685-1", "uniprot_id": [ { "id": "AT1A1_RAT", "url": "https://www.uniprot.org/uniprot/P06685", "type": "external" } ], "mass": 113054.0, "length": 1023, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-1", "gene_name": "Atp1a1", "organism": "Rat", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_036636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036636", "type": "external" } ], "gene_names_uniprotkb": "Atp1a1", "gene_names_refseq": "Atp1a1; Nkaa1b", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-1; 7.2.2.13; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1 precursor; sodium/potassium-transporting ATPase subunit alpha-1", "tax_id": 10116, "disease": "familial hemiplegic migraine (Disease Ontology:DOID:0060178); Charcot-Marie-Tooth disease type 2DD (Disease Ontology:DOID:0111558); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:24211); (R-RNO-5578775); (R-RNO-936837)", "pathway_count": 3, "publication_count": 31, "publication_id_list": "10473631;10823893;12730684;15240697;15743908;16075062;16269407;16723354;16914892;17283221;17939993;19339511;21454685;2166579;22673903;23532852;27605582;2822682;2822726;29499166;2994074;3028470;30388404;34315852;34502162;36919600;38843836;41549750;7510709;7775468;9435504", "class_list": "", "function": "Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:17939993, PubMed:30388404). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Evidence That Binding of Cyclic GMP to the Extracellular Domain of NKA (Sodium-Potassium ATPase) Mediates Natriuresis., [RefSeq, PubMed]; Identified a well conserved Na,K-ATPase catalytic alpha-subunit motif that binds to the inositol 1,4,5-trisphosphate receptor and can trigger an anti-apoptotic calcium signal., [RefSeq, PubMed]; Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad. Publication Status: Online-Only, [RefSeq, PubMed]; The the TM domain of FXYD7 has a role in mediating the complex interactions of FXYD7 with Na,K-ATPase, [RefSeq, PubMed]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64609", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" }, { "id": "7.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0046982 protein heterodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007231 osmosensory signaling pathway;GO:0055085 transmembrane transport;GO:0008217 regulation of blood pressure;GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "P06685-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19357-1", "uniprot_id": [ { "id": "GLUT4_RAT", "url": "https://www.uniprot.org/uniprot/P19357", "type": "external" } ], "mass": 54896.0, "length": 509, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 4", "gene_name": "Slc2a4", "organism": "Rat", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 4 isoform a", "refseq_ac": [ { "id": "NP_036883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036883", "type": "external" } ], "gene_names_uniprotkb": "Slc2a4; Glut4", "gene_names_refseq": "Glut4; Slc2a4", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; Glucose transporter type 4, insulin-responsive", "protein_names_refseq": "GLUT-4; Glucose transporter 4, insuline-responsive; glucose transporter 4 insulin-responsive; glucose transporter type 4, insulin-responsive; insulin responsive glucose transporter; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2, facilitated glucose transporter member 4 isoform a; solute carrier family 2, member 4", "tax_id": 10116, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Perry syndrome (Disease Ontology:DOID:0060486); autosomal dominant distal hereditary motor neuronopathy 14 (Disease Ontology:DOID:0111202); motor neuron disease (Disease Ontology:DOID:231); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25139); (R-RNO-189200)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "16000877;16396496;1651337;2211693;22673903;26240143;2645527;2649253;2649883;37073948;37673038;37715078;38950736;39240727;7545962;7720644;8573180;9059504", "class_list": "", "function": "Exercise preconditioning promotes myocardial GLUT4 translocation and induces autophagy to alleviate exhaustive exercise-induced myocardial injury in rats., [RefSeq, PubMed]; Immunoglobulin-Mediated Cardiac Protection From Ischemia/Reperfusion Injury in Diabetic Rats Is Associated With Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Impact of Normal and Overweight Pregnancy in GLUT4 and Glucose-Dependent Vascular Contractility., [RefSeq, PubMed]; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:2211693, PubMed:2645527, PubMed:2649253). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:2211693, PubMed:2645527, PubMed:2649253). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:2211693, PubMed:2645527, PubMed:2649253)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle. Publication Status: Online-Only, [RefSeq, PubMed]; The SIRT3/GSK-3beta/GLUT4 axis might be involved in maternal hypoxia-induced skeletal muscle insulin resistance in old male rat offspring., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97900", "ec_number_list": [], "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity;GO:0015304 D-glucose uniporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0007611 learning or memory;GO:0032869 cellular response to insulin stimulus;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P19357-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21575-1", "uniprot_id": [ { "id": "DYN1_RAT", "url": "https://www.uniprot.org/uniprot/P21575", "type": "external" } ], "mass": 97295.0, "length": 864, "protein_name": "Dynamin-1", "gene_name": "Dnm1", "organism": "Rat", "refseq_name": "dynamin-1", "refseq_ac": [ { "id": "NP_542420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542420", "type": "external" } ], "gene_names_uniprotkb": "Dnm1; Dnm", "gene_names_refseq": "Dnm1; Dnm", "protein_names_uniprotkb": "Dynamin-1; 3.6.5.5; B-dynamin; D100; Dynamin I; Dynamin, brain", "protein_names_refseq": "B-dynamin; D100; dynamin I; dynamin, brain; dynamin-1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 31B (Disease Ontology:DOID:0070376); developmental and epileptic encephalopathy 31A (Disease Ontology:DOID:0080437); Alzheimer's disease (Disease Ontology:DOID:10652); generalized epilepsy (Disease Ontology:DOID:1827); collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:140694); (R-RNO-166016); (R-RNO-190873); (R-RNO-196025); (R-RNO-2132295); (R-RNO-437239); (R-RNO-8856828)", "pathway_count": 7, "publication_count": 17, "publication_id_list": "11872741;12855954;12896979;15252117;15287745;16141317;17257598;17376771;18683930;2144893;21927001;22673903;25964652;38744819;9238017;9341169;9725914", "class_list": "", "function": "Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks. Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis. Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission. May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (By similarity). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses. Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells. Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098835 presynaptic endocytic zone membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0051260 protein homooligomerization;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P21575-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26431-1", "uniprot_id": [ { "id": "SL9A1_RAT", "url": "https://www.uniprot.org/uniprot/P26431", "type": "external" } ], "mass": 91647.0, "length": 820, "protein_name": "Sodium/hydrogen exchanger 1", "gene_name": "Slc9a1", "organism": "Rat", "refseq_name": "sodium/hydrogen exchanger 1", "refseq_ac": [ { "id": "NP_036784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036784", "type": "external" } ], "gene_names_uniprotkb": "Slc9a1; Nhe1", "gene_names_refseq": "Nhe1; Slc9a1", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 1; NHE-1; Na(+)/H(+) exchanger 1; Solute carrier family 9 member 1", "protein_names_refseq": "NHE-1; Na(+)/H(+) exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 19 (Disease Ontology:DOID:0080065); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); renovascular hypertension (Disease Ontology:DOID:1591); middle cerebral artery infarction (Disease Ontology:DOID:3525); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); cataract (Disease Ontology:DOID:83); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24782); (R-RNO-2160916); (R-RNO-425986)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10893269;11163215;12576672;1577762;18321853;21543739;22673903;32496418;33957206;34063987;34774621;34813134;35921220;6334130;9688597", "class_list": "", "function": "Burn-Induced Apoptosis of Pulmonary Microvascular Endothelial Cell is NHE1 Dependent and Regulated by PI3K-Akt and p38 MAPK Pathways., [RefSeq, PubMed]; Citronellal alleviates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis via Na(+) /H(+) exchanger-1 inhibition. Erratum:[J Biochem Mol Toxicol. 2025 Jun;39(6):e70337. doi: 10.1002/jbt.70337. PMID: 40495642], [RefSeq, PubMed]; Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (Probable) (PubMed:10893269, PubMed:11163215). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:6334130). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:34774621). In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Interaction of NHE1 and TRPA1 Activity in DRG Neurons Isolated from Adult Rats and its Role in Inflammatory Nociception., [RefSeq, PubMed]; Low-Dose Empagliflozin Improves Systolic Heart Function after Myocardial Infarction in Rats: Regulation of MMP9, NHE1, and SERCA2a. Publication Status: Online-Only, [RefSeq, PubMed]; MiRNA-23a modulates sodium-hydrogen exchanger 1 expression: studies in medullary thick ascending limb of salt-induced hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0070417 cellular response to cold;GO:0086003 cardiac muscle cell contraction;GO:0086092 regulation of the force of heart contraction by cardiac conduction;GO:0030154 cell differentiation;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26431-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31421-1", "uniprot_id": [ { "id": "GRM2_RAT", "url": "https://www.uniprot.org/uniprot/P31421", "type": "external" } ], "mass": 95774.0, "length": 872, "protein_name": "Metabotropic glutamate receptor 2", "gene_name": "Grm2", "organism": "Rat", "refseq_name": "metabotropic glutamate receptor 2 precursor", "refseq_ac": [ { "id": "NP_001099181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099181", "type": "external" } ], "gene_names_uniprotkb": "Grm2; Gprc1b; Mglur2", "gene_names_refseq": "Grm2; mGlu2", "protein_names_uniprotkb": "Metabotropic glutamate receptor 2; mGluR2", "protein_names_refseq": "glutamate receptor, metabotropic 2; mGluR2; metabotropic glutamate receptor 2 precursor; metabotropic glutamate receptor 2", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24415); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11850456;1309649;32534177;32640261;33201416;37917117;38843836", "class_list": "", "function": "Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Group II metabotropic glutamate receptor activation in the basolateral amygdala mediates individual differences in stress-induced changes in rapid eye movement sleep., [RefSeq, PubMed]; Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure., [RefSeq, PubMed]; Modulation by chronic stress and ketamine of ionotropic AMPA/NMDA and metabotropic glutamate receptors in the rat hippocampus., [RefSeq, PubMed]; Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0097110 scaffold protein binding;GO:0001641 group II metabotropic glutamate receptor activity;GO:0008066 glutamate receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0014048 regulation of glutamate secretion;GO:0035095 behavioral response to nicotine;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0014059 regulation of dopamine secretion;GO:0060292 long-term synaptic depression", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31421-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P747-1", "uniprot_id": [ { "id": "HP1B3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P747", "type": "external" } ], "mass": 60807.0, "length": 553, "protein_name": "Heterochromatin protein 1-binding protein 3", "gene_name": "Hp1bp3", "organism": "Rat", "refseq_name": "heterochromatin protein 1-binding protein 3 isoform a", "refseq_ac": [ { "id": "NP_954539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954539", "type": "external" } ], "gene_names_uniprotkb": "Hp1bp3", "gene_names_refseq": "Hp1bp3", "protein_names_uniprotkb": "Heterochromatin protein 1-binding protein 3", "protein_names_refseq": "heterochromatin protein 1-binding protein 3 isoform a", "tax_id": 10116, "disease": "", "pathway": " (rno:313647)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031491 nucleosome binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0000786 nucleosome", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0071456 cellular response to hypoxia;GO:0006334 nucleosome assembly;GO:0097298 regulation of nucleus size", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P747-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM73-1", "uniprot_id": [ { "id": "KCY_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM73", "type": "external" } ], "mass": 22169.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "Cmpk1", "organism": "Rat", "refseq_name": "UMP-CMP kinase", "refseq_ac": [ { "id": "NP_001020826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020826", "type": "external" } ], "gene_names_uniprotkb": "Cmpk1; CMPK1; CMPK; Cmpk", "gene_names_refseq": "CK; Cmpk1; Cmpk; RGD1310116", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "UMP-CMP kinase 1; UMP-CMP kinase; UMP/CMPK; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidine monophosphate kinase; cytidylate kinase; dCMP kinase; deoxycytidylate kinase; nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": " (rno:298410); (R-RNO-499943)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0050145 nucleoside monophosphate kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0022602 ovulation cycle process;GO:0018963 phthalate metabolic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006225 UDP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62897-1", "uniprot_id": [ { "id": "KCND3_RAT", "url": "https://www.uniprot.org/uniprot/Q62897", "type": "external" } ], "mass": 73513.0, "length": 655, "protein_name": "A-type voltage-gated potassium channel KCND3", "gene_name": "Kcnd3", "organism": "Rat", "refseq_name": "A-type voltage-gated potassium channel KCND3 isoform 1", "refseq_ac": [ { "id": "NP_001257891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257891", "type": "external" } ], "gene_names_uniprotkb": "Kcnd3", "gene_names_refseq": "Kcnd3; Kv4.3", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND3; Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv4.3", "protein_names_refseq": "A-type voltage-gated potassium channel KCND3 isoform 1; A-type voltage-gated potassium channel KCND3; potassium channel, voltage-gated Shal-related subfamily D, member 3; potassium voltage gated channel, Shal-related family, member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; voltage-gated potassium channel subunit Kv4.3", "tax_id": 10116, "disease": "spinocerebellar ataxia 19/22 (Disease Ontology:DOID:0050970); Brugada syndrome 9 (Disease Ontology:DOID:0110226)", "pathway": " (rno:65195); (R-RNO-1296072); (R-RNO-5576894)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10676964;11427525;11805342;12006572;15456698;17057713;19213956;22673903;29313436;30462989;31935048;33254430;33472822;8734615;8831489;9001401;9314834;9450548", "class_list": "", "function": "Down-regulation of Kv4.3 channels mediating A-type K(+) (IA) currents currents in nociceptive V2 trigeminal neurons is an underlying mechanism of oxaliplatin-induced orofacial neuropathic pain., [RefSeq, PubMed]; Immunogold staining and electron microscopy of heart vibrosections was performed to localize Kv4.2/Kv4.3 and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins. Patch-Clamp recordings in control conditions and after lipid raft or caveolae disruption show that the CaMKII-Kv4 channel complex must associate in non-caveolar lipid rafts to be functional., [RefSeq, PubMed]; Kv4.3 Channel Dysfunction Contributes to Trigeminal Neuropathic Pain Manifested with Orofacial Cold Hypersensitivity in Rats., [RefSeq, PubMed]; Kv4.3 reduction is an important mediator in cardiac hypertrophy development via excessive CaMKII activation., [RefSeq, PubMed]; Over-expression of Kv4.3 gene reverses cardiac remodeling and transient-outward K(+) current (Ito) reduction via CaMKII inhibition in myocardial infarction., [RefSeq, PubMed]; Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:17057713, PubMed:8734615, PubMed:8831489, PubMed:9001401, PubMed:9450548). In cardiomyocytes, may generate the transient outward potassium current I(To) (Probable). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (Probable). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed:17057713, PubMed:8734615, PubMed:8831489, PubMed:9001401, PubMed:9450548). Channel properties are modulated by interactions with regulatory subunits (PubMed:10676964, PubMed:17057713). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed:10676964, PubMed:17057713). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08723;P70622;Q63286;Q99P42", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0005216 monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0005267 potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:0099625 ventricular cardiac muscle cell membrane repolarization;GO:0051260 protein homooligomerization;GO:0051262 protein tetramerization;GO:0001508 action potential", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q62897-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1N3-1", "uniprot_id": [ { "id": "MYO9A_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1N3", "type": "external" } ], "mass": 301382.0, "length": 2626, "protein_name": "Unconventional myosin-IXa", "gene_name": "Myo9a", "organism": "Rat", "refseq_name": "unconventional myosin-IXa", "refseq_ac": [ { "id": "NP_599162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599162", "type": "external" } ], "gene_names_uniprotkb": "Myo9a; Myr7", "gene_names_refseq": "Myo9a; myr 7", "protein_names_uniprotkb": "Unconventional myosin-IXa; Myr 7; Unconventional myosin-9a", "protein_names_refseq": "myosin-IXa; unconventional myosin-9a; unconventional myosin-IXa", "tax_id": 10116, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); obstructive hydrocephalus (Disease Ontology:DOID:14159); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (rno:171296); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013424)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;38843836;9819351", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating its GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0034329 cell junction assembly;GO:0035556 intracellular signal transduction;GO:0045198 establishment of epithelial cell apical/basal polarity;GO:0150011 regulation of neuron projection arborization;GO:0099084 postsynaptic specialization organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z1N3-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81718-1", "uniprot_id": [ { "id": "PTN6_RAT", "url": "https://www.uniprot.org/uniprot/P81718", "type": "external" } ], "mass": 69578.0, "length": 613, "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "Ptpn6", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 6", "refseq_ac": [ { "id": "NP_446360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446360", "type": "external" } ], "gene_names_uniprotkb": "Ptpn6; Ptph6", "gene_names_refseq": "Ptph6; Ptpn6; Shp-1", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 6; 3.1.3.48; Protein-tyrosine phosphatase SHP-1", "protein_names_refseq": "SH2 phosphatase 1; protein-tyrosine phosphatase SHP-1; tyrosine-protein phosphatase non-receptor type 6", "tax_id": 10116, "disease": "juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); Noonan syndrome 1 (Disease Ontology:DOID:0060578); anogenital venereal wart (Disease Ontology:DOID:11168); leukemia (Disease Ontology:DOID:1240); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (rno:116689); (R-RNO-114604); (R-RNO-1433559); (R-RNO-201556); (R-RNO-210990); (R-RNO-389948); (R-RNO-432142); (R-RNO-512988); (R-RNO-5690714); (R-RNO-6798695); (R-RNO-877300); (R-RNO-912526); (R-RNO-912694); (R-RNO-983695); (R-RNO-9927353)", "pathway_count": 15, "publication_count": 8, "publication_id_list": "17068200;18713988;22673903;29758384;31967332;33207073;33932446;34872449", "class_list": "", "function": "Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1))., [RefSeq, PubMed]; Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure., [RefSeq, PubMed]; Results revealed a specific regulation by SHP1 of GluN2A-dependent pain transmission. Authors provided evidence that interference with SHP1/GluN2A interaction in spinal dorsal horn generated an effective analgesic action against inflammatory pain., [RefSeq, PubMed]; SHP-1 suppresses endotoxin-induced uveitis by inhibiting the TAK1/JNK pathway. Erratum:[J Cell Mol Med. 2022 Jul;26(13):3808. doi: 10.1111/jcmm.17446. PMID: 35793029], [RefSeq, PubMed]; Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling. Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A., [UniProtKB, UniProtKB, PubMed]; Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0001784 phosphotyrosine residue binding;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0045577 regulation of B cell differentiation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0000278 mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation;GO:0018108 peptidyl-tyrosine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P81718-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0N7-1", "uniprot_id": [ { "id": "KCNQ1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0N7", "type": "external" } ], "mass": 74579.0, "length": 669, "protein_name": "Potassium voltage-gated channel subfamily KQT member 1", "gene_name": "Kcnq1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily KQT member 1", "refseq_ac": [ { "id": "NP_114462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114462", "type": "external" } ], "gene_names_uniprotkb": "Kcnq1; Kcna9; Kvlqt1", "gene_names_refseq": "Kcnq1; Kvlqt1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1", "protein_names_refseq": "IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; voltage-gated potassium channel subunit Kv7.1", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); short QT syndrome (Disease Ontology:DOID:0050793); atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 1 (Disease Ontology:DOID:0110644); hypertension (Disease Ontology:DOID:10763); Jervell-Lange Nielsen syndrome (Disease Ontology:DOID:2842); long QT syndrome (Disease Ontology:DOID:2843); seminoma (Disease Ontology:DOID:4440); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:84020); (R-RNO-1296072); (R-RNO-5576890); (R-RNO-5576893)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "11220365;21911611;23529131;28189443;28611207;32248813;33667331;34907346;9314834", "class_list": "", "function": "Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered., [RefSeq, PubMed]; In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress., [RefSeq, PubMed]; KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea., [RefSeq, PubMed]; Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression. Publication Status: Online-Only, [RefSeq, PubMed]; Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:21911611). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:11220365). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (PubMed:11220365). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:11220365). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (PubMed:21911611). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5 that has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O08655", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization;GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0034236 protein kinase A catalytic subunit binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0060453 regulation of gastric acid secretion;GO:0086011 membrane repolarization during action potential;GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z0N7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1L3-1", "uniprot_id": [ { "id": "PTN20_RAT", "url": "https://www.uniprot.org/uniprot/A1L1L3", "type": "external" } ], "mass": 48580.0, "length": 421, "protein_name": "Tyrosine-protein phosphatase non-receptor type 20", "gene_name": "Ptpn20", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 20", "refseq_ac": [ { "id": "NP_001073618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073618", "type": "external" } ], "gene_names_uniprotkb": "Ptpn20", "gene_names_refseq": "Ptpn20b; Ptpn20", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 20; 3.1.3.48", "protein_names_refseq": "protein tyrosine phosphatase, non-receptor type 20B; tyrosine-protein phosphatase non-receptor type 20", "tax_id": 10116, "disease": "", "pathway": " (rno:306281)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16641100;22673903;35658898", "class_list": "", "function": "Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0034451 centriolar satellite", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1L1L3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62921-1", "uniprot_id": [ { "id": "HOIL1_RAT", "url": "https://www.uniprot.org/uniprot/Q62921", "type": "external" } ], "mass": 57685.0, "length": 508, "protein_name": "RanBP-type and C3HC4-type zinc finger-containing protein 1", "gene_name": "Rbck1", "organism": "Rat", "refseq_name": "ranBP-type and C3HC4-type zinc finger-containing protein 1", "refseq_ac": [ { "id": "NP_068532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068532", "type": "external" } ], "gene_names_uniprotkb": "Rbck1; Pkcbpb15; Rbck; Ubce7ip3", "gene_names_refseq": "HOIL-1; Pkcbpb15; Rbck1", "protein_names_uniprotkb": "RanBP-type and C3HC4-type zinc finger-containing protein 1; 2.3.2.31; HOIL-1; Heme-oxidized IRP2 ubiquitin ligase 1 homolog; Protein kinase C-binding protein beta-15; RBCC protein interacting with PKC; RING-type E3 ubiquitin transferase HOIL-1; Ubiquitin-conjugating enzyme 7-interacting protein 3", "protein_names_refseq": "RBCC protein interacting with PKC 1; RING-type E3 ubiquitin transferase HOIL-1; RanBP-type and C3HC4-type zinc finger containing 1; heme-oxidized IRP2 ubiquitin ligase 1 homolog; protein kinase C-binding protein Beta15; protein kinase C-binding protein beta-15; ranBP-type and C3HC4-type zinc finger-containing protein 1; ubiquitin-conjugating enzyme 7-interacting protein 3", "tax_id": 10116, "disease": "glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:60383); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-983168)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15833741;18303026;9514928;9755849", "class_list": "", "function": "E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates (By similarity). Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination (By similarity). Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome (PubMed:18303026). Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (By similarity). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (By similarity). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (By similarity). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (By similarity). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (By similarity). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (By similarity). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity). Binds polyubiquitin of different linkage types (By similarity)., [UniProtKB, PubMed, UniProtKB]; RBCK1 (human C20orf18 and rat Pkcbpb15) is involved in transcriptional machinery in the nuclear bodies, and its transcriptional activity is regulated by nucleocytoplasmic shuttling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWN4;Q9Z334", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0050852 T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62921-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9X9-1", "uniprot_id": [ { "id": "PARM1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9X9", "type": "external" } ], "mass": 30729.0, "length": 296, "protein_name": "Prostate androgen-regulated mucin-like protein 1 homolog", "gene_name": "Parm1", "organism": "Rat", "refseq_name": "prostate androgen-regulated mucin-like protein 1 homolog precursor", "refseq_ac": [ { "id": "NP_775137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775137", "type": "external" } ], "gene_names_uniprotkb": "Parm1; Cipar1", "gene_names_refseq": "CIPAR-1; Cipar1; PARM-1; Parm1", "protein_names_uniprotkb": "Prostate androgen-regulated mucin-like protein 1 homolog; CIPAR-1; Castration-induced prostatic apoptosis-related protein 1; PARM-1; Prostatic androgen-repressed message 1 protein", "protein_names_refseq": "castration-induced prostatic apoptosis-related protein 1; prostate androgen-regulated mucin-like protein 1 homolog precursor; prostate androgen-regulated mucin-like protein 1 homolog; prostatic androgen-repressed message 1 protein; prostatic androgen-repressed message-1", "tax_id": 10116, "disease": "", "pathway": " (rno:286894)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10499539;12772192;20305782;22673903;24085821;37047359", "class_list": "", "function": "May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis., [UniProtKB, PubMed, PubMed]; PARM-1 is a novel ER transmembrane molecule involved in cardiac remodeling in hypertensive heart disease GeneRIF: PARM-1 is an ER protein in cardiac myocytes, whose expression is enhanced by ER stress and in the hearts of hypertensive heart disease model of Dahl salt-sensitive rats. PARM-1 has a protective role against ER stress-induced apoptosis in cardiac myocytes. Publication Status: Online-Only, [RefSeq, PubMed]; PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis. Publication Status: Online-Only, [RefSeq, PubMed]; PARM1 contributes to ovulation and/or luteal function by acting as a novel regulator of progesterone metabolism., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 4, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z0P0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005770 late endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P9X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15385-1", "uniprot_id": [ { "id": "KCNA4_RAT", "url": "https://www.uniprot.org/uniprot/P15385", "type": "external" } ], "mass": 73390.0, "length": 655, "protein_name": "Potassium voltage-gated channel subfamily A member 4", "gene_name": "Kcna4", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily A member 4", "refseq_ac": [ { "id": "NP_037103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037103", "type": "external" } ], "gene_names_uniprotkb": "Kcna4", "gene_names_refseq": "KCHAN; Kcna4; Kv1.4; Kv4; RHK1; RK3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 4; RCK4; RHK1; RK3; Voltage-gated potassium channel subunit Kv1.4", "protein_names_refseq": "RCK4; potassium channel, voltage gated shaker related subfamily A, member 4; potassium voltage-gated channel subfamily A member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; voltage-gated potassium channel subunit Kv1.4", "tax_id": 10116, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); spermatogenic failure 46 (Disease Ontology:DOID:0112164); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:25469); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 21, "publication_id_list": "10896669;11988171;12590144;12632190;1497894;16000151;16504945;22673903;23413915;2348860;2384173;24082096;24423395;2555158;28054303;31487241;7477295;8361540;8495559;9000078;9334400", "class_list": "", "function": "Endogenous H2S generating enzyme cystathionine-beta-synthetase was co-localized well with Kv1.1 and Kv1.4 in trigeminal ganglion neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Four prolines and four lysines in a Kv1.4 homotetramer might provide a binding site for a putative endoplasmic reticulum-export molecule to ensure high cell surface protein expression of the channel., [RefSeq, PubMed]; Kv1.4 K(+) channels are potently regulated by intracellular free heme; heme binds to the N-terminal inactivation domain and thereby impairs the inactivation process, [RefSeq, PubMed]; Neuronal and behavioral outputs associated with low motivation were linked to faster inactivation of a voltage-gated potassium channel, Kv1.4. Publication Status: Online-Only, [RefSeq, PubMed]; Synaptotagmin I is an interacting protein of Kv1.4 channel. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10896669, PubMed:2348860, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:2384173). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:2348860)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005216 monoatomic ion channel activity;GO:0005267 potassium channel activity;GO:0030955 potassium ion binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P15385-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62726-1", "uniprot_id": [ { "id": "CILK1_RAT", "url": "https://www.uniprot.org/uniprot/Q62726", "type": "external" } ], "mass": 70569.0, "length": 629, "protein_name": "Serine/threonine-protein kinase ICK", "gene_name": "Cilk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase ICK", "refseq_ac": [ { "id": "NP_620241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620241", "type": "external" } ], "gene_names_uniprotkb": "Cilk1; Ick", "gene_names_refseq": "Cilk1; Ick", "protein_names_uniprotkb": "Serine/threonine-protein kinase ICK; 2.7.11.1; Intestinal cell kinase; MAK-related kinase; MRK", "protein_names_refseq": "MAK-related kinase; MRK; heart serine-threonine protein kinase; intestinal cell (MAK-like) kinase; intestinal cell kinase; serine/threonine-protein kinase ICK", "tax_id": 10116, "disease": "endocrine-cerebro-osteodysplasia syndrome (Disease Ontology:DOID:0060641); juvenile myoclonic epilepsy 10 (Disease Ontology:DOID:0111325)", "pathway": " (rno:84411)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8570168", "class_list": "", "function": "Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development (PubMed:8570168). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0060271 cilium assembly;GO:0042073 intraciliary transport;GO:0035720 intraciliary anterograde transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62726-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70377-1", "uniprot_id": [ { "id": "SNP23_RAT", "url": "https://www.uniprot.org/uniprot/O70377", "type": "external" } ], "mass": 23235.0, "length": 210, "protein_name": "Synaptosomal-associated protein 23", "gene_name": "Snap23", "organism": "Rat", "refseq_name": "synaptosomal-associated protein 23 isoform 1", "refseq_ac": [ { "id": "NP_073180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073180", "type": "external" } ], "gene_names_uniprotkb": "Snap23; AABR07053516.1", "gene_names_refseq": "Snap23", "protein_names_uniprotkb": "Synaptosomal-associated protein 23; SNAP-23; Vesicle-membrane fusion protein SNAP-23", "protein_names_refseq": "SNAP-23; synaptosomal-associated protein 23 isoform 1; synaptosomal-associated protein 23; synaptosomal-associated protein, 23 kD; vesicle-membrane fusion protein SNAP-23", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:64630); (R-RNO-1236974); (R-RNO-199992); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013149); (R-RNO-9013406); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 10, "publication_count": 10, "publication_id_list": "10051443;14993220;15035620;15611044;28240595;28784843;29485121;33213278;34147527;37057886", "class_list": "", "function": "Blocking dephosphorylation at serine 120 residue in SNAP-23 leads to massive inhibition in exocytosis from mast cells., [RefSeq, PubMed]; Electrostatic anchoring precedes stable membrane attachment of SNAP25 and SNAP23 to the plasma membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion., [UniProtKB, UniProtKB]; PKCepsilon controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode., [RefSeq, PubMed]; Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes., [RefSeq, PubMed]; SNAP-23 is expressed in alveolar type II cells of the lung; evidence supports its functional role in exocytosis of lung surfactant by alveolar type II cells., [RefSeq, PubMed]; SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A., [RefSeq, PubMed]; SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:14993220). SNAP23 is a t-SNARE (target-SNARE) that resides on target membrane and functions in the fusion of transport vesicles with the plasma membrane in immune cells. In macrophages, regulates the stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with STX11 and thereby plays a critical role in the recognition of microbial components and the induction of innate and adaptive immunity. In skeletal muscle satellite cells, SNAP23 cooperates with its cognate SNAREs VAMP4 and STX11 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPL8", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0061025 membrane fusion;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O70377-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02625-1", "uniprot_id": [ { "id": "PRVA_RAT", "url": "https://www.uniprot.org/uniprot/P02625", "type": "external" } ], "mass": 11926.0, "length": 110, "protein_name": "Parvalbumin alpha", "gene_name": "Pvalb", "organism": "Rat", "refseq_name": "parvalbumin alpha", "refseq_ac": [ { "id": "NP_071944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071944", "type": "external" } ], "gene_names_uniprotkb": "Pvalb; Pva", "gene_names_refseq": "PALB1; Pvalb; Pva", "protein_names_uniprotkb": "Parvalbumin alpha; Alpha-PV; Alpha-parvalbumin", "protein_names_refseq": "Parvalbumin (calcium binding protein); alpha-PV; alpha-parvalbumin; parvalbumin alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:25269)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10036163;11562941;15169955;15287728;16101280;18218708;19622856;22673903;29788232;3009434;30176502;3036821;31804491;3707914;37127359;38100162;3856270;6754379;8289291", "class_list": "", "function": "Chronic mild stress induced a specific decrease of parvalbumin expression in the dorsal hippocampus, an effect normalized by lurasidone treatment. Interestingly, the regulation of parvalbumin levels was correlated to the modulation of the antioxidant master regulator NRF2 and its chaperon protein KEAP1, which were also modulated by pharmacological intervention., [RefSeq, PubMed]; Dendritic inhibition differentially controls input-output transformations in parvalbumin-expressing interneurons (PVIs) and granule cells (GCs) of the dentate gyrus. Publication Status: Online-Only, [RefSeq, PubMed]; Hippocampal parvalbumin and perineuronal nets: Possible involvement in anxiety-like behavior in rats., [RefSeq, PubMed]; In muscle, parvalbumin is thought to be involved in relaxation after contraction (By similarity). It binds two calcium ions (PubMed:19622856, PubMed:16101280, PubMed:15169955, PubMed:15287728, PubMed:11562941, PubMed:8289291)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions., [UniProtKB, UniProtKB, UniProtKB]; Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats., [RefSeq, PubMed]; These results demonstrate that amino acids of the cluster I of beta parvalbumin provide more essential contribution to the maintenance of structural and functional properties of the protein in comparison with the residues of the cluster II., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN21", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0098976 excitatory chemical synaptic transmission;GO:0010467 gene expression;GO:0090102 cochlea development;GO:0098977 inhibitory chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P02625-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04094-1", "uniprot_id": [ { "id": "PENK_RAT", "url": "https://www.uniprot.org/uniprot/P04094", "type": "external" } ], "mass": 30932.0, "length": 269, "protein_name": "Proenkephalin-A", "gene_name": "Penk", "organism": "Rat", "refseq_name": "proenkephalin-A precursor", "refseq_ac": [ { "id": "NP_001416509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416509", "type": "external" } ], "gene_names_uniprotkb": "Penk; Penk-rs; Penk1", "gene_names_refseq": "Enk; Penk-rs; Penk1; Penk2; Penk", "protein_names_uniprotkb": "Proenkephalin-A; BAM(8-22); Bovine adrenal medulla peptide 20; Bovine adrenal medulla peptide 22; Bovine adrenal medulla peptide 8-22; OGF; Opioid growth factor", "protein_names_refseq": "enkephalin; preproenkephalin 2; proenkephalin 1; proenkephalin 2; proenkephalin related sequence; proenkephalin-A precursor; proenkephalin-A", "tax_id": 10116, "disease": "spinal disease (Disease Ontology:DOID:0060564); overactive bladder syndrome (Disease Ontology:DOID:0070355); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826); dystonia (Disease Ontology:DOID:543); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:29237); (R-RNO-375276); (R-RNO-381426); (R-RNO-418594); (R-RNO-8957275)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10.1039/D0MO00044B;1438982;17767492;19164277;20487892;22673903;2582088;27072528;2707437;28423013;29169417;3093884;32184167;34106099;6094550;6548748;6594709;6744032;7089582;8624732", "class_list": "", "function": "Increases glutamate release in the striatum and decreases GABA concentration in the striatum., [UniProtKB, PubMed]; Increases glutamate release in the striatum., [UniProtKB, PubMed]; Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rat forebrain has been reported. Publication Status: Online-Only, [RefSeq, PubMed]; Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:8624732). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (By similarity)., [UniProtKB, UniProtKB, PubMed]; Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress., [UniProtKB, UniProtKB]; Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations. Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain., [UniProtKB, UniProtKB]; Neuropeptide that mediates stress-induced opioid analgesia (PubMed:17767492, PubMed:6744032, PubMed:7089582). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Preproenkephalin-minimalistic immunologically defined gene expression-nuclear localization signal (PPENK-MIDGE-NLS) vector postconditioning can mitigate myocardial ischemia reperfusion injury by promoting mitophagy., [RefSeq, PubMed]; Study found that miRNA let-7b-5p was increased as electroacupuncture tolerance occurred in rats with the complete Freund's Adjuvant-induced inflammatory nociception. The let-7b-5p contributed to the formation of EA tolerance by downregulating Penk1 gene., [RefSeq, PubMed]; The findings of thus study suggest that, in parkinsonian animals treated with l-DOPA, high levels of PPENK are a prerequisite for a locomotor sensitization to l-DOPA treatment, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 2, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53X05", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0048018 receptor ligand activity;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0001964 startle response;GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0032496 response to lipopolysaccharide;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P04094-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04550-1", "uniprot_id": [ { "id": "PTMS_RAT", "url": "https://www.uniprot.org/uniprot/P04550", "type": "external" } ], "mass": 11559.0, "length": 102, "protein_name": "Parathymosin", "gene_name": "Ptms", "organism": "Rat", "refseq_name": "parathymosin", "refseq_ac": [ { "id": "NP_114181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114181", "type": "external" } ], "gene_names_uniprotkb": "Ptms; Znbp", "gene_names_refseq": "Ptms; ZnBP", "protein_names_uniprotkb": "Parathymosin; Zinc-binding 11.5 kDa protein", "protein_names_refseq": "parathymosin; zinc binding protein; zinc-binding 11.5 kDa protein", "tax_id": 10116, "disease": "", "pathway": " (rno:83801)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1544455;22673903;2759245;29393594;3377505;3421960;3456585;3856246", "class_list": "", "function": "Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04550-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07687-1", "uniprot_id": [ { "id": "HYEP_RAT", "url": "https://www.uniprot.org/uniprot/P07687", "type": "external" } ], "mass": 52582.0, "length": 455, "protein_name": "Epoxide hydrolase 1", "gene_name": "Ephx1", "organism": "Rat", "refseq_name": "epoxide hydrolase 1", "refseq_ac": [ { "id": "NP_001029262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029262", "type": "external" } ], "gene_names_uniprotkb": "Ephx1; Eph-1", "gene_names_refseq": "Ephx1; MEH8; mEH", "protein_names_uniprotkb": "Epoxide hydrolase 1; 3.3.2.9; Epoxide hydratase; Microsomal epoxide hydrolase; mEH", "protein_names_refseq": "epoxide hydratase; epoxide hydrolase 1 (microsomal xenobiotic hydrolase); epoxide hydrolase 1, microsomal (xenobiotic); epoxide hydrolase 1; liver microsomal xenobiotic epoxide hydrolase; microsomal epoxide hydrolase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); bone disease (Disease Ontology:DOID:0080001); asbestosis (Disease Ontology:DOID:10320); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); aplastic anemia (Disease Ontology:DOID:12449); Parkinson's disease (Disease Ontology:DOID:14330); respiratory system disease (Disease Ontology:DOID:1579); cancer (Disease Ontology:DOID:162); anemia (Disease Ontology:DOID:2355); hematologic cancer (Disease Ontology:DOID:2531); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); toxic encephalopathy (Disease Ontology:DOID:3602); insulinoma (Disease Ontology:DOID:3892); lung non-small cell carcinoma (Disease Ontology:DOID:3908); aflatoxins-related hepatocellular carcinoma (Disease Ontology:DOID:5022); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); pulmonary emphysema (Disease Ontology:DOID:9675); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25315); (R-RNO-211945)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15047867;28736260;3032949;3755318;9245728;9854022", "class_list": "", "function": "Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; These findings show the critical role of soluble epoxide hydrolase S-nitrosation in cardiac ischemia-reperfusion injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0019899 enzyme binding;GO:0004301 epoxide hydrolase activity;GO:0033961 cis-stilbene-oxide hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001889 liver development;GO:0009636 response to toxic substance;GO:0071385 cellular response to glucocorticoid stimulus;GO:0034312 diol biosynthetic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P07687-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10499-1", "uniprot_id": [ { "id": "KCNA1_RAT", "url": "https://www.uniprot.org/uniprot/P10499", "type": "external" } ], "mass": 56379.0, "length": 495, "protein_name": "Potassium voltage-gated channel subfamily A member 1", "gene_name": "Kcna1", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily A member 1", "refseq_ac": [ { "id": "NP_775118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775118", "type": "external" } ], "gene_names_uniprotkb": "Kcna1", "gene_names_refseq": "Kcna1; Kcna; Kcpvd; Kv1.1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 1; RBKI; RCK1; Voltage-gated potassium channel subunit Kv1.1", "protein_names_refseq": "IA; RBKI; RCK1; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; potassium voltage-gated channel subfamily A member 1; voltage-gated potassium channel subunit Kv1.1", "tax_id": 10116, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (rno:24520); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 31, "publication_id_list": "10884227;10896669;11086297;12114518;12177193;12681381;12777451;12907802;16306173;16504945;17855588;17869444;17917103;20805574;21483673;22206926;22673903;23318870;2348860;23725331;25270294;2539643;25514171;26348848;3191911;35053355;36750122;38615163;7477295;8038169;9334400", "class_list": "", "function": "Ion Channel Modeling beyond State of the Art: A Comparison with a System Theory-Based Model of the Shaker-Related Voltage-Gated Potassium Channel Kv1.1. Publication Status: Online-Only, [RefSeq, PubMed]; Key role for Kv11.1 (ether-a-go-go related gene) channels in rat bladder contractility., [RefSeq, PubMed]; MiR-21-5p alleviates trigeminal neuralgia in rats through down-regulation of voltage-gated potassium channel Kv1.1., [RefSeq, PubMed]; Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent. Publication Status: Online-Only, [RefSeq, PubMed]; This stuidy demonstrated that kainic-acid induced status epilepticus there are two phases of Kv1.1 repression: (1) an initial mTOR-dependent repression of Kv1.1 that is followed by (2) a miR-129-5p persistent reduction of Kv1.1., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability (PubMed:12177193, PubMed:17855588, PubMed:22206926). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:23725331). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2539643). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10896669, PubMed:12177193, PubMed:2348860, PubMed:23725331). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:10896669, PubMed:12114518). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA1 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:12681381, PubMed:22206926, PubMed:2348860, PubMed:23725331, PubMed:8038169). In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:2348860). Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (PubMed:12177193, PubMed:23318870). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (PubMed:16306173). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) release (PubMed:17869444). Plays a role in regulating the generation of action potentials and preventing hyperexcitability in myelinated axons of the vagus nerve, and thereby contributes to the regulation of heart contraction (By similarity). Required for normal neuromuscular responses (PubMed:22206926). Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception of pain due to heat stimuli (By similarity). Required for normal responses to auditory stimuli and precise location of sound sources, but not for sound perception (By similarity). The use of toxins that block specific channels suggest that it contributes to the regulation of the axonal release of the neurotransmitter dopamine (By similarity). Required for normal postnatal brain development and normal proliferation of neuronal precursor cells in the brain (By similarity). Plays a role in the reabsorption of Mg(2+) in the distal convoluted tubules in the kidney and in magnesium ion homeostasis, probably via its effect on the membrane potential (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0097718 disordered domain specific binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0044305 calyx of Held;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0001964 startle response;GO:0086011 membrane repolarization during action potential;GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0023041 neuronal signal transduction;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P10499-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15384-1", "uniprot_id": [ { "id": "KCNA3_RAT", "url": "https://www.uniprot.org/uniprot/P15384", "type": "external" } ], "mass": 58425.0, "length": 525, "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "Kcna3", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily A member 3", "refseq_ac": [ { "id": "NP_062143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062143", "type": "external" } ], "gene_names_uniprotkb": "Kcna3", "gene_names_refseq": "Kcna3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 3; RCK3; RGK5; Voltage-gated potassium channel subunit Kv1.3; Voltage-gated potassium channel subunit Kv3", "protein_names_refseq": "KV3; RCK3; RGK5; potassium channel, voltage gated shaker related subfamily A, member 3; potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; voltage-gated potassium channel subunit Kv1.3; voltage-gated potassium channel subunit Kv3", "tax_id": 10116, "disease": "episodic ataxia type 1 (Disease Ontology:DOID:0050989); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29731); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "19773357;22613618;2351830;2361015;2555158;27802162;28623364;29574670;30612588;32370164;36440534;7477295;8774427", "class_list": "", "function": "Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex. Publication Status: Online-Only, [RefSeq, PubMed]; Interactions of fibroblast-like synoviocytes in collagen-induced arthritis are regulated by Kv1.3 and KCa1.1 Publication Status: Online-Only, [RefSeq, PubMed]; Kv1.3 may be a therapeutic target of interest for multiple sclerosis and add astrocytes to the list of cells whose activation would be suppressed by inhibiting Kv1.3 in inflammatory conditions, [RefSeq, PubMed]; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Spinal voltage-gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome., [RefSeq, PubMed]; The high stability and bioavailability, low normal-tissue uptake of [(64)Cu]Cu-NOTA-HsTX1[R14A], and accumulation in regions of up-regulated Kv channels both in vitro and in vivo demonstrate that HsTX1[R14A] represents a valuable lead for conditions treatable by blockade of the voltage-gated potassium channel Kv1.3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0021554 optic nerve development;GO:0022038 corpus callosum development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P15384-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16636-1", "uniprot_id": [ { "id": "LYOX_RAT", "url": "https://www.uniprot.org/uniprot/P16636", "type": "external" } ], "mass": 46559.0, "length": 411, "protein_name": "Protein-lysine 6-oxidase", "gene_name": "Lox", "organism": "Rat", "refseq_name": "protein-lysine 6-oxidase precursor", "refseq_ac": [ { "id": "NP_001400932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001400932", "type": "external" } ], "gene_names_uniprotkb": "Lox", "gene_names_refseq": "H-rev142; Lox; Rrg1", "protein_names_uniprotkb": "Protein-lysine 6-oxidase; 1.4.3.13; Lysyl oxidase", "protein_names_refseq": "Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts); protein-lysine 6-oxidase precursor; protein-lysine 6-oxidase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Menkes disease (Disease Ontology:DOID:1838); Williams-Beuren syndrome (Disease Ontology:DOID:1928); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); coronary restenosis (Disease Ontology:DOID:4247); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:24914); (R-RNO-1566948); (R-RNO-2243919)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1349020;16432278;1678281;1973052;26479776;29502979;32979358;35011567;37095518;8636146", "class_list": "", "function": "Elastic Laminar Reorganization Occurs with Outward Diameter Expansion during Collateral Artery Growth and Requires Lysyl Oxidase for Stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; LOX over-activation contributes to penile fibrosis and LOX inhibition could be a promising strategy in preventing the progression of cavernous nerve injury-induced erectile dysfunction., [RefSeq, PubMed]; LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure. Erratum:[Cell Commun Signal. 2024 Mar 26;22(1):192. doi: 10.1186/s12964-024-01579-w. PMID: 38532448] Publication Status: Online-Only, [RefSeq, PubMed]; Lysyl oxidase inhibits TNF-alpha induced rat nucleus pulposus cell apoptosis via regulating Fas/FasL pathway and the p53 pathways., [RefSeq, PubMed]; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:16432278). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005518 collagen binding;GO:0005507 copper ion binding;GO:0036094 small molecule binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005581 collagen trimer", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0016202 regulation of striated muscle tissue development;GO:0071897 DNA biosynthetic process;GO:1990869 cellular response to chemokine;GO:1903010 regulation of bone development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16636-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19024-1", "uniprot_id": [ { "id": "KCNA5_RAT", "url": "https://www.uniprot.org/uniprot/P19024", "type": "external" } ], "mass": 66553.0, "length": 602, "protein_name": "Potassium voltage-gated channel subfamily A member 5", "gene_name": "Kcna5", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily A member 5", "refseq_ac": [ { "id": "NP_037104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037104", "type": "external" } ], "gene_names_uniprotkb": "Kcna5", "gene_names_refseq": "Kcna5; Kv1.5; Kv1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 5; RCK7; RK4; Voltage-gated potassium channel subunit Kv1.5", "protein_names_refseq": "Potassium (K+) channel protein alpha 5; RCK7; RK4; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage-gated channel subfamily A member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel subunit Kv1.5", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); episodic ataxia type 1 (Disease Ontology:DOID:0050989); primary ciliary dyskinesia 40 (Disease Ontology:DOID:0111853); sensorineural hearing loss (Disease Ontology:DOID:10003); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); epilepsy (Disease Ontology:DOID:1826); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:25470); (R-RNO-1296072); (R-RNO-5576890)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "11709425;15277200;15618540;1705709;2361015;27062501;27522126;27958660;28011270;30636484;8253777", "class_list": "", "function": "AMPK selectively inhibits Kv1.5 in pulmonary arterial myocytes, [RefSeq, PubMed]; Ang II selectively stimulates degradation of KV1.5 channels to reduce functional KV1.5 channel surface abundance in mesenteric artery myocytes, [RefSeq, PubMed]; Expression of Kv1.5 and 4-aminopyridine (Kv channel special inhibitor)-sensitive Kv current were correlated with the inhibition of miR-206 in PA rings of IUGR - CH rats and cultured IUGR PASMC s exposed to hypoxia. Thus, miR-206 may be a trigger for induction of exaggerated CH-pulmonary artery hypertension of IUGR via Kv1.5., [RefSeq, PubMed]; H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during atrial fibrillation, [RefSeq, PubMed]; This study demonstrates for the first time an altered gene and protein expression of NFATc2 and KV1.5 in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Upregulation of NFATc2 with concomitant downregulation of KV1.5 channels may contribute to abnormal vascular remodeling., [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15618540, PubMed:2361015). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:15618540). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:15618540). Homotetrameric channels display rapid activation and slow inactivation. Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity). May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6LEB7", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0005251 delayed rectifier potassium channel activity;GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:0015271 outward rectifier potassium channel activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0007219 Notch signaling pathway;GO:0042391 regulation of membrane potential;GO:0051259 protein complex oligomerization;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P19024-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37230-1", "uniprot_id": [ { "id": "PPARA_RAT", "url": "https://www.uniprot.org/uniprot/P37230", "type": "external" } ], "mass": 52377.0, "length": 468, "protein_name": "Peroxisome proliferator-activated receptor alpha", "gene_name": "Ppara", "organism": "Rat", "refseq_name": "peroxisome proliferator-activated receptor alpha", "refseq_ac": [ { "id": "NP_037328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037328", "type": "external" } ], "gene_names_uniprotkb": "Ppara; Nr1c1; Ppar", "gene_names_refseq": "PPAR; Ppara", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1; PPAR-alpha", "protein_names_refseq": "PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferator-activated receptor alpha", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); morbid obesity (Disease Ontology:DOID:11981); alcoholic hepatitis (Disease Ontology:DOID:12351); cystic fibrosis (Disease Ontology:DOID:1485); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); coronary artery disease (Disease Ontology:DOID:3393); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); diabetes mellitus (Disease Ontology:DOID:9351); hypertensive encephalopathy (Disease Ontology:DOID:9427); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25747); (R-RNO-383280); (R-RNO-400206); (R-RNO-4090294); (R-RNO-9707564)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "1316614;15051727;16042408;36219352;36401357;37204637;38956068;8828512", "class_list": "", "function": "Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3eta. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity)., [UniProtKB]; MiR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome., [RefSeq, PubMed]; PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha Activation in Rats Fed High-Fat Diet., [RefSeq, PubMed]; Swimming exercise activates peroxisome proliferator-activated receptor-alpha and mitigates age-related renal fibrosis in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development;GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:1903944 negative regulation of hepatocyte apoptotic process;GO:0046209 nitric oxide metabolic process;GO:2001171 positive regulation of ATP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P37230-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48548-1", "uniprot_id": [ { "id": "KCNJ5_RAT", "url": "https://www.uniprot.org/uniprot/P48548", "type": "external" } ], "mass": 47783.0, "length": 419, "protein_name": "G protein-activated inward rectifier potassium channel 4", "gene_name": "Kcnj5", "organism": "Rat", "refseq_name": "G protein-activated inward rectifier potassium channel 4", "refseq_ac": [ { "id": "NP_058993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058993", "type": "external" } ], "gene_names_uniprotkb": "Kcnj5; Girk4", "gene_names_refseq": "Kcnj5", "protein_names_uniprotkb": "G protein-activated inward rectifier potassium channel 4; CIR; Cardiac inward rectifier; GIRK-4; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5", "protein_names_refseq": "CIR; G protein-activated inward rectifier potassium channel 4; GIRK-4; GIRK4; KATP-1; cardiac inward rectifier; heart KATP channel; inward rectifier K(+) channel Kir3.4; potassium channel, inwardly rectifying subfamily J member 5; potassium voltage-gated channel subfamily J member 5", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 13 (Disease Ontology:DOID:0110654); primary hyperaldosteronism (Disease Ontology:DOID:446)", "pathway": " (rno:29713); (R-RNO-1296041); (R-RNO-997272)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "21653876;22465809;24148898;25696012;26487066;7592809;7877685;8047164;8834003;9486652", "class_list": "", "function": "Blocking IK,ACh-c by tertiapin significantly decreased DFT, which correlated with a significant increase in wavelength during reentry. Genetic knockdown experiments with Kcnj5-specific shRNA to modulate IK,ACh-c, yielded similar results Publication Status: Online-Only, [RefSeq, PubMed]; Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle., [RefSeq, PubMed]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins., [UniProtKB, PubMed, PubMed, PubMed]; Localized in intercalated discs in rat ventricle, whereas it was expressed in intercalated discs and outer sarcolemmas in rat atrium, [RefSeq, PubMed]; The GIRK4 channel protein plays a role in regulating membrane excitability in chemically defined neurons of the arcuate nucleus that control body weight, [RefSeq, PubMed]; The KCNJ5 gene and Kir3.4 protein were measured, and acetylcholine-sensitive potassium channel currents were recorded by patch-clamp., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:0015467 G-protein activated inward rectifier potassium channel activity;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:1902937 inward rectifier potassium channel complex;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0008076 voltage-gated potassium channel complex;GO:0030315 T-tubule", "go_biological_process": "GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:1990573 potassium ion import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48548-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51886-1", "uniprot_id": [ { "id": "LUM_RAT", "url": "https://www.uniprot.org/uniprot/P51886", "type": "external" } ], "mass": 38279.0, "length": 338, "protein_name": "Lumican", "gene_name": "Lum", "organism": "Rat", "refseq_name": "lumican precursor", "refseq_ac": [ { "id": "NP_112312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112312", "type": "external" } ], "gene_names_uniprotkb": "Lum; Lcn; Ldc", "gene_names_refseq": "Lum", "protein_names_uniprotkb": "Lumican; KSPG lumican; Keratan sulfate proteoglycan lumican", "protein_names_refseq": "KSPG lumican; keratan sulfate proteoglycan lumican; lumican precursor", "tax_id": 10116, "disease": "myopia (Disease Ontology:DOID:11830); Ehlers-Danlos syndrome classic type 1 (Disease Ontology:DOID:14720); pancreatic cancer (Disease Ontology:DOID:1793); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); ureteral obstruction (Disease Ontology:DOID:5199); varicose veins (Disease Ontology:DOID:799)", "pathway": " (rno:81682); (R-RNO-2022854); (R-RNO-2022857); (R-RNO-216083)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;32235499", "class_list": "", "function": "Immunolocalization of Keratan Sulfate in Rat Spinal Tissues Using the Keratanase Generated BKS-1(+) Neoepitope: Correlation of Expression Patterns with the Class II SLRPs, Lumican and Keratocan. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005583 fibrillar collagen trimer", "go_biological_process": "GO:1904010 response to Aroclor 1254;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0070848 response to growth factor;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51886-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63142-1", "uniprot_id": [ { "id": "KCNA2_RAT", "url": "https://www.uniprot.org/uniprot/P63142", "type": "external" } ], "mass": 56701.0, "length": 499, "protein_name": "Potassium voltage-gated channel subfamily A member 2", "gene_name": "Kcna2", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily A member 2", "refseq_ac": [ { "id": "NP_037102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037102", "type": "external" } ], "gene_names_uniprotkb": "Kcna2", "gene_names_refseq": "BK2; Kcna2; NGK1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 2; RAK; RBK2; RCK5; Voltage-gated potassium channel subunit Kv1.2", "protein_names_refseq": "Potassium (K+) channel protein alpha 2, voltage dependent; Potassium voltage gated channel shaker related subfamily member 2; RAK; RBK2; RCK5; potassium channel, voltage gated shaker related subfamily A, member 2; potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; voltage-gated potassium channel subunit Kv1.2", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); episodic ataxia type 1 (Disease Ontology:DOID:0050989); developmental and epileptic encephalopathy 32 (Disease Ontology:DOID:0080416); primary ciliary dyskinesia 3 (Disease Ontology:DOID:0110599); sensorineural hearing loss (Disease Ontology:DOID:10003); otitis media (Disease Ontology:DOID:10754); epilepsy (Disease Ontology:DOID:1826); tetralogy of Fallot (Disease Ontology:DOID:6419); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:25468); (R-RNO-1296072)", "pathway_count": 2, "publication_count": 53, "publication_id_list": "10624965;10896669;11007484;11086297;11739373;12151401;12177193;12632190;12777451;14713306;15151918;15618540;16002579;16002581;16210348;16306173;16770729;1715584;17324383;17766348;17869444;17917103;18003609;18004376;18056633;18638484;19403695;19713757;20089912;20360102;20534430;20805574;21602278;21647367;22673903;23318870;23705070;23725331;24472174;25514171;2555158;2722779;29263036;31140423;32315300;32621322;34632937;7477295;7544443;8355670;8361540;8495559;9635436", "class_list": "", "function": "Epigenetic restoration of voltage-gated potassium channel Kv1.2 alleviates nerve injury-induced neuropathic pain. Erratum:[J Neurochem. 2022 Mar;160(6):675. doi: 10.1111/jnc.15584. PMID: 35288944], [RefSeq, PubMed]; The expression of KCNA2 is decreased in the DRG neurons of rats with OA pain likely as a result of enhanced methylation of Kcna2 promoter region, [RefSeq, PubMed]; Two residues E327 and H418 in the proximity of the water cavity of Kv1.2 play crucial roles as a pH switch Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons., [RefSeq, PubMed]; Ventricular Kcna2 AS expression increases in rats with CHF and contributes to reduced IKs, prolonged APs, and the occurrence of ventricular arrhythmias by silencing Kcna2. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:12151401, PubMed:21602278, PubMed:24472174). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:15618540, PubMed:20805574, PubMed:23725331, PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels (PubMed:18003609, PubMed:19713757). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to a particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed:16770729, PubMed:1715584, PubMed:17766348, PubMed:18003609, PubMed:18638484, PubMed:19713757, PubMed:20089912). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons (PubMed:23318870). KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing (PubMed:12777451). Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination (PubMed:16210348). Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus (By similarity). May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons (PubMed:16306173). May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) (PubMed:17869444). Contributes to the regulation of the axonal release of the neurotransmitter dopamine (PubMed:21647367). Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain (PubMed:24472174). Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 45, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P15386;Q02010", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015271 outward rectifier potassium channel activity;GO:0019894 kinesin binding;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0034705 potassium channel complex;GO:0044305 calyx of Held;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0021633 optic nerve structural organization;GO:0019228 neuronal action potential;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0014059 regulation of dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 5.5, "record_id": "P63142-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63161-1", "uniprot_id": [ { "id": "KCNE2_RAT", "url": "https://www.uniprot.org/uniprot/P63161", "type": "external" } ], "mass": 14356.0, "length": 123, "protein_name": "Potassium voltage-gated channel subfamily E member 2", "gene_name": "Kcne2", "organism": "Rat", "refseq_name": "potassium voltage-gated channel subfamily E member 2", "refseq_ac": [ { "id": "NP_598287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598287", "type": "external" } ], "gene_names_uniprotkb": "Kcne2", "gene_names_refseq": "Kcne2; Mirp1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E member 2; MiRP1; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1", "protein_names_refseq": "minK-related peptide 1; minimum potassium ion channel-related peptide 1; potassium channel subunit beta MiRP1; potassium channel, voltage gated subfamily E regulatory beta subunit 2; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2; potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; potassium voltage-gated channel, Isk-related subfamily, gene 2", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); atrial fibrillation (Disease Ontology:DOID:0060224); long QT syndrome 6 (Disease Ontology:DOID:0110648); long QT syndrome (Disease Ontology:DOID:2843)", "pathway": " (rno:171138); (R-RNO-5576890); (R-RNO-5576893)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10219239;11420311;14679187;15066947;17717828;19219384;21943417;22180649;23504710;24681347;26297229", "class_list": "", "function": "Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:11420311, PubMed:19219384). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (By similarity). May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (By similarity). May associate with HCN1 and HCN2 channel subunits to increase potassium current (PubMed:11420311). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration., [RefSeq, PubMed]; In aging rat ventricle, KCNE2 may associate with HCN2 and enhance its current amplitude. KCNE2 protein is expressed in ventricles, and it can play diverse roles in ventricular electrical activity under (patho)physiological conditions., [RefSeq, PubMed]; KCNE1 and KCNE2 suppress currents generated by homomeric Kv1.4, Kv3.3, and Kv3.4 channels, [RefSeq, PubMed]; KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells., [RefSeq, PubMed]; KCNE2 can modulate its partner channel function not only by altering channel conductance and/or gating kinetics, but also by affecting protein stability., [RefSeq, PubMed]; The KCNE2 mutation R27C may induce familial atrial fibrillation partially through enhancing the suppression of Cav1.2 calcium channel., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVT9;Q9WTW0", "ec_number_list": [], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0042802 identical protein binding;GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903817 negative regulation of voltage-gated potassium channel activity;GO:0060306 regulation of membrane repolarization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67999-1", "uniprot_id": [ { "id": "KS6B1_RAT", "url": "https://www.uniprot.org/uniprot/P67999", "type": "external" } ], "mass": 59132.0, "length": 525, "protein_name": "Ribosomal protein S6 kinase beta-1", "gene_name": "Rps6kb1", "organism": "Rat", "refseq_name": "ribosomal protein S6 kinase beta-1", "refseq_ac": [ { "id": "NP_114191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114191", "type": "external" } ], "gene_names_uniprotkb": "Rps6kb1", "gene_names_refseq": "Rps6kb1; p70 S6K-alpha", "protein_names_uniprotkb": "Ribosomal protein S6 kinase beta-1; 2.7.11.1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; Ribosomal protein S6 kinase I; S6K-beta-1; S6K1; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70 ribosomal S6 kinase alpha; p70-S6K 1", "protein_names_refseq": "70 kDa ribosomal protein S6 kinase 1; P70S6K1; P70S6K; S6K-beta-1; S6K1; S6K; p70 S6 kinase alpha; p70 S6KA; p70 ribosomal S6 kinase alpha; p70(S6K)-alpha; p70-S6K 1; ribosomal protein S6 kinase I; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); glucose metabolism disease (Disease Ontology:DOID:4194); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83840); (R-RNO-166208)", "pathway_count": 2, "publication_count": 22, "publication_id_list": "11516946;11967149;12183455;12604610;15774499;1699226;20599721;2236064;22673903;25706655;28178239;32601203;34655015;34874016;36527650;38570425;39236462;8524831;9427642;9465032;9632736;9653190", "class_list": "", "function": "Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of the hepatic mTOR/S6K1/SREBP1 signalling pathway in rats at different ages: from neonates to adults., [RefSeq, PubMed]; Lactate-upregulated ARG2 expression induces cellular senescence in fibroblast-like synoviocytes of osteoarthritis via activating the mTOR/S6K1 signaling pathway., [RefSeq, PubMed]; MTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats. Publication Status: Online-Only, [RefSeq, PubMed]; Role of the mTOR Signalling Pathway During Extracellular Acidosis in Tumour Cells., [RefSeq, PubMed]; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression (PubMed:8524831). Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD (By similarity). Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex (By similarity). Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation (By similarity). The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B (By similarity). Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis (By similarity). Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR (By similarity). In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2 (By similarity). Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating MAPKAP1/SIN1, MTOR and RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling (By similarity). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (By similarity). Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function (By similarity). Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex (By similarity). The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function (By similarity). Mediates TNF-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1 (By similarity). In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B (By similarity). May be involved in cytoskeletal rearrangement through binding to neurabin (PubMed:9653190). Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (By similarity). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P21425", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.20", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0031670 cellular response to nutrient;GO:0003009 skeletal muscle contraction;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "P67999-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97541-1", "uniprot_id": [ { "id": "HSPB6_RAT", "url": "https://www.uniprot.org/uniprot/P97541", "type": "external" } ], "mass": 17505.0, "length": 162, "protein_name": "Heat shock protein beta-6", "gene_name": "Hspb6", "organism": "Rat", "refseq_name": "heat shock protein beta-6", "refseq_ac": [ { "id": "NP_620242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620242", "type": "external" } ], "gene_names_uniprotkb": "Hspb6", "gene_names_refseq": "Hsp20; Hspb6; p20", "protein_names_uniprotkb": "Heat shock protein beta-6; Heat shock 20 kDa-like protein p20; Hsp20; HspB6", "protein_names_refseq": "heat shock 20 kDa-like protein p20; heat shock 20-kDa protein; heat shock protein beta-6; heat shock protein family B (small) member B6; heat shock protein, alpha-crystallin-related, B6", "tax_id": 10116, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093)", "pathway": " (rno:192245)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "12551873;14615292;15105294;16385579;19646995;22673903;25889640;26443497;27977738;30511325;34502162;8195168;8921906", "class_list": "", "function": "Activation of the cAMP-PKA pathway induces overexpression and partial phosphorylation of HspB6 lead to the inhibition of ASK1 expression., [RefSeq, PubMed]; Formation of the Hsp20-PKD1 complex is essential for PKD1 nuclear translocation, signaling mechanisms leading to hypertrophy Publication Status: Online-Only, [RefSeq, PubMed]; Localization, macromolecular associations, and function of HSP20 in the heart., [RefSeq, PubMed]; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (By similarity). Seems to have versatile functions in various biological processes (By similarity). Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility (By similarity). May regulate myocardial angiogenesis implicating KDR (By similarity). Overexpression mediates cardioprotection and angiogenesis after induced damage (PubMed:15105294). Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study delineates the protein kinase D1 binding sites on HSP20 and shows that HSP20 is a substrate for protein kinase D1., [RefSeq, PubMed]; We show for the first time that alphaB-crystallin, a molecular chaperon for tubulin/microtubules, is involved in cell shape determination. knockdown of this molecule caused myoblasts and glioma cells to lose their ability for adhesion as they tended to behave like migratory cells. knockdown in both C6 glial cells and L6 myoblast permitted cells to migrate more rapidly than dermal fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045766 positive regulation of angiogenesis;GO:0006457 protein folding;GO:0009408 response to heat;GO:0010667 negative regulation of cardiac muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P97541-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63068-1", "uniprot_id": [ { "id": "PHAX_RAT", "url": "https://www.uniprot.org/uniprot/Q63068", "type": "external" } ], "mass": 43166.0, "length": 385, "protein_name": "Phosphorylated adapter RNA export protein", "gene_name": "Phax", "organism": "Rat", "refseq_name": "phosphorylated adapter RNA export protein", "refseq_ac": [ { "id": "NP_775156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775156", "type": "external" } ], "gene_names_uniprotkb": "Phax; Rnuxa", "gene_names_refseq": "Phax; Rnuxa", "protein_names_uniprotkb": "Phosphorylated adapter RNA export protein; 26 kDa resiniferatoxin-binding protein; RBP-26; RBP-2; RNA U small nuclear RNA export adapter protein; RTX-42; Resiniferatoxin-binding protein 2", "protein_names_refseq": "26 kDa resiniferatoxin-binding protein; RBP-26; RBP-2; RNA U small nuclear RNA export adapter protein; RNA U, small nuclear RNA export adaptor; RTX-42; cytosolic resiniferatoxin-binding protein; phosphorylated adapter RNA export protein; resiniferatoxin-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:286917); (R-RNO-6807505)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;8015392", "class_list": "", "function": "A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQW9;Q5RJZ7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0015643 toxic substance binding;GO:0140262 mRNA cap binding complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0015030 Cajal body", "go_biological_process": "GO:0015031 protein transport;GO:0006408 snRNA export from nucleus;GO:0043489 RNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63068-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63187-1", "uniprot_id": [ { "id": "ELOA1_RAT", "url": "https://www.uniprot.org/uniprot/Q63187", "type": "external" } ], "mass": 87203.0, "length": 773, "protein_name": "Elongin-A", "gene_name": "Eloa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eloa; Tceb3", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongin-A; EloA; Elongin 110 kDa subunit; RNA polymerase II transcription factor SIII subunit A1; SIII p110; Transcription elongation factor B polypeptide 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "dentin caries (Disease Ontology:DOID:10461); candidiasis (Disease Ontology:DOID:1508)", "pathway": " (R-RNO-112382); (R-RNO-674695); (R-RNO-6796648); (R-RNO-75955)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "22673903;28292928;29393594;7660129;8244996;8896449", "class_list": "", "function": "As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0070449 elongin complex;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63187-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63881-1", "uniprot_id": [ { "id": "KCND2_RAT", "url": "https://www.uniprot.org/uniprot/Q63881", "type": "external" } ], "mass": 70549.0, "length": 630, "protein_name": "A-type voltage-gated potassium channel KCND2", "gene_name": "Kcnd2", "organism": "Rat", "refseq_name": "A-type voltage-gated potassium channel KCND2", "refseq_ac": [ { "id": "NP_113918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113918", "type": "external" } ], "gene_names_uniprotkb": "Kcnd2", "gene_names_refseq": "Kcnd2; Kv4.2; RK5; Shal1", "protein_names_uniprotkb": "A-type voltage-gated potassium channel KCND2; Potassium voltage-gated channel subfamily D member 2; RK5; Shal1; Voltage-gated potassium channel subunit Kv4.2", "protein_names_refseq": "A-type voltage-gated potassium channel KCND2; potassium channel, voltage-gated Shal-related subfamily D, member 2; potassium voltage gated channel, Shal-related family, member 2; potassium voltage-gated channel, Shal-related subfamily, member 2; voltage-gated potassium channel subunit Kv4.2", "tax_id": 10116, "disease": "", "pathway": " (rno:65180); (R-RNO-1296072); (R-RNO-5576894)", "pathway_count": 3, "publication_count": 57, "publication_id_list": "10676964;10681507;10860776;11080179;11102480;11805342;11847232;11923279;12451113;12575952;12592409;12754210;12829703;12835418;14559911;14980206;14980207;15356203;15452711;15485870;15671030;15736227;15858231;16123112;16207878;16820361;17026528;1705709;1722463;17582333;17917103;18276729;18357523;18371079;1840649;18650329;19213956;19279261;19441798;19901547;20045463;20224290;22098631;22673903;24037673;24404150;24793047;24811166;25352783;27346450;28566490;29996472;31935048;32554946;9058605;9070739;9093524", "class_list": "", "function": "Immunogold staining and electron microscopy of heart vibrosections was performed to localize Kv4.2/Kv4.3 and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) proteins. Patch-Clamp recordings in control conditions and after lipid raft or caveolae disruption show that the CaMKII-Kv4 channel complex must associate in non-caveolar lipid rafts to be functional., [RefSeq, PubMed]; Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation., [RefSeq, PubMed]; NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2., [RefSeq, PubMed]; Study revealed that ERK5 signaling promotes phosphorylation of Kv4.2 and inhibits the inactivation of the A-type current for the enhancement of membrane excitability in PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart (PubMed:10676964, PubMed:12592409, PubMed:12754210, PubMed:14980206, PubMed:16123112, PubMed:16207878, PubMed:1722463, PubMed:1840649, PubMed:19279261, PubMed:25352783, PubMed:9058605, PubMed:9093524). Mediates the major part of the dendritic A-type current I(SA) in brain neurons (PubMed:16207878, PubMed:17026528). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member (PubMed:9058605, PubMed:9093524). Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:10676964, PubMed:12451113, PubMed:12592409, PubMed:12754210, PubMed:14980206, PubMed:15452711, PubMed:16207878, PubMed:16820361, PubMed:1722463, PubMed:1840649, PubMed:25352783, PubMed:9093524). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel (PubMed:25352783). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes (PubMed:12451113, PubMed:16123112). Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:12451113, PubMed:14980206, PubMed:15452711, PubMed:16123112, PubMed:16820361, PubMed:20045463). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (PubMed:15671030, PubMed:16123112, PubMed:19279261, PubMed:19441798, PubMed:19901547). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q00090;Q99249", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0005267 potassium channel activity;GO:1905030 voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006936 muscle contraction;GO:0019228 neuronal action potential;GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 5.8, "record_id": "Q63881-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC8-1", "uniprot_id": [ { "id": "GGN_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC8", "type": "external" } ], "mass": 67501.0, "length": 658, "protein_name": "Gametogenetin", "gene_name": "Ggn", "organism": "Rat", "refseq_name": "gametogenetin isoform 1", "refseq_ac": [ { "id": "NP_001013083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013083", "type": "external" } ], "gene_names_uniprotkb": "Ggn", "gene_names_refseq": "Ggn", "protein_names_uniprotkb": "Gametogenetin", "protein_names_refseq": "gametogenetin isoform 1", "tax_id": 10116, "disease": "spermatogenic failure 69 (Disease Ontology:DOID:0070568)", "pathway": " (rno:292765)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in spermatogenesis., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 0, "predicted_o_glycosites": 10, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006302 double-strand break repair;GO:0008104 intracellular protein localization;GO:0007566 embryo implantation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66HC8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ54-1", "uniprot_id": [ { "id": "HEMGN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ54", "type": "external" } ], "mass": 56573.0, "length": 514, "protein_name": "Hemogen", "gene_name": "Hemgn", "organism": "Rat", "refseq_name": "hemogen", "refseq_ac": [ { "id": "NP_001376186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376186", "type": "external" } ], "gene_names_uniprotkb": "Hemgn; Rp59", "gene_names_refseq": "Edag-1; Edag1; Hemgn; Hgn; RP59", "protein_names_uniprotkb": "Hemogen; Hemopoietic gene protein; Protein RP59", "protein_names_refseq": "erythroid differentiation gene 1; hemogen; hemopoietic gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:113882)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11161722;11891990;15726423;22673903;29393594", "class_list": "", "function": "RP59, a marker for osteoblast recruitment, is also detected in primitive mesenchymal cells, erythroid cells, and megakaryocytes., [RefSeq, PubMed]; Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER23", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0045667 regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AZ54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JEL3-1", "uniprot_id": [ { "id": "KLH10_RAT", "url": "https://www.uniprot.org/uniprot/Q6JEL3", "type": "external" } ], "mass": 68962.0, "length": 608, "protein_name": "Kelch-like protein 10", "gene_name": "Klhl10", "organism": "Rat", "refseq_name": "kelch-like protein 10", "refseq_ac": [ { "id": "NP_001001510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001510", "type": "external" } ], "gene_names_uniprotkb": "Klhl10", "gene_names_refseq": "Klhl10", "protein_names_uniprotkb": "Kelch-like protein 10", "protein_names_refseq": "kelch-like protein 10", "tax_id": 10116, "disease": "spermatogenic failure 11 (Disease Ontology:DOID:0070180)", "pathway": " (rno:303533)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15136734;22673903", "class_list": "", "function": "May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0009566 fertilization;GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0048873 homeostasis of number of cells within a tissue;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6JEL3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VH49-1", "uniprot_id": [ { "id": "HIG1A_RAT", "url": "https://www.uniprot.org/uniprot/Q8VH49", "type": "external" } ], "mass": 10301.0, "length": 93, "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "Higd1a", "organism": "Rat", "refseq_name": "HIG1 domain family member 1A, mitochondrial", "refseq_ac": [ { "id": "NP_543178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543178", "type": "external" } ], "gene_names_uniprotkb": "Higd1a; Hig1", "gene_names_refseq": "Hig1; Higd1a", "protein_names_uniprotkb": "HIG1 domain family member 1A, mitochondrial; Hypoxia-inducible gene 1 protein", "protein_names_refseq": "HIG1 domain family member 1A, mitochondrial; HIG1 domain family, member 1A; hypoxia induced gene 1; hypoxia-inducible gene 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:140937)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15968589;22350989;22673903;30302618", "class_list": "", "function": "Hgd1a expression in central nervous system varies according to age., [RefSeq, PubMed]; Hig-1 protein and human- and murine-predicted sequences, as well as its characteristic expression in the Central Nervous System, are indicative of a specific role which could be related to apoptosis signaling during postnatal maturation., [RefSeq, PubMed]; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity)., [UniProtKB]; We found an interesting change in the protein expression pattern, shifting from neurons at P1 to glial cells at P90, which points towards a functional role for this protein in the spinal cord throughout development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PCV5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0071456 cellular response to hypoxia;GO:0042149 cellular response to glucose starvation;GO:0071902 positive regulation of protein serine/threonine kinase activity;GO:0090201 negative regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8VH49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPX0-1", "uniprot_id": [ { "id": "HSPB8_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPX0", "type": "external" } ], "mass": 21592.0, "length": 196, "protein_name": "Heat shock protein beta-8", "gene_name": "Hspb8", "organism": "Rat", "refseq_name": "heat shock protein beta-8", "refseq_ac": [ { "id": "NP_446064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446064", "type": "external" } ], "gene_names_uniprotkb": "Hspb8; Cryac; Hsp22", "gene_names_refseq": "Cryac; Hsp22; Hspb8", "protein_names_uniprotkb": "Heat shock protein beta-8; Alpha-crystallin C chain; HspB8; Small stress protein-like protein HSP22", "protein_names_refseq": "alpha-crystallin C chain; crystallin, alpha C; heat shock 22kDa protein 8; heat shock protein 8; heat shock protein B8; heat shock protein beta-8; small stress protein-like protein HSP22", "tax_id": 10116, "disease": "myofibrillar myopathy 13 with rimmed vacuoles (Disease Ontology:DOID:0051045); Charcot-Marie-Tooth disease axonal type 2L (Disease Ontology:DOID:0110174); autosomal dominant distal hereditary motor neuronopathy 2 (Disease Ontology:DOID:0111206)", "pathway": " (rno:113906); (R-RNO-3371571)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11342557;15030316;22673903;30422312;33472123;33478532;36644958;38319409", "class_list": "", "function": "DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy., [RefSeq, PubMed]; HSP22 (HSPB8) positively regulates PGF2alpha-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; HSPB8 over-expression noticeably prevented blood-brain barrier disruption after cerebral ischemia/reperfusion injury... and this protective role was, at least in part, mediated through autophagy, [RefSeq, PubMed]; Heat Shock Protein 22 Attenuates Nerve Injury-induced Neuropathic Pain Via Improving Mitochondrial Biogenesis and Reducing Oxidative Stress Mediated By Spinal AMPK/PGC-1alpha Pathway in Male Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1alpha signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats., [RefSeq, PubMed]; Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0034620 cellular response to unfolded protein;GO:1905337 positive regulation of aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9EPX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESP4-1", "uniprot_id": [ { "id": "GPR88_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESP4", "type": "external" } ], "mass": 40200.0, "length": 384, "protein_name": "G protein-coupled receptor 88", "gene_name": "Gpr88", "organism": "Rat", "refseq_name": "G protein-coupled receptor 88", "refseq_ac": [ { "id": "NP_113884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113884", "type": "external" } ], "gene_names_uniprotkb": "Gpr88; Strg", "gene_names_refseq": "Gpr88", "protein_names_uniprotkb": "G protein-coupled receptor 88; Striatum-specific G protein-coupled receptor", "protein_names_refseq": "G protein-coupled receptor 88; probable G-protein coupled receptor 88; striatum-specific G-protein coupled receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:64443)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11056049;19656174;25155879;26918661;28678544;32667145", "class_list": "", "function": "G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease. Publication Status: Online-Only, [RefSeq, PubMed]; GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels, [RefSeq, PubMed]; In the developing cortex, GPR88 shifts on the day of birth to the nuclei of neurons in layers V to II., [RefSeq, PubMed]; Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (PubMed:25155879). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (By similarity). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (By similarity). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Results suggest a role for Gpr88 in the regulation of cognitive and motor functions, and support its relevance to the pathophysiology and treatment of schizophrenia and other disorders involving dysfunction of the accumbens-striatal complex, [RefSeq, PubMed]; Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004941 beta2-adrenergic receptor activity;GO:0003774 cytoskeletal motor activity;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007626 locomotory behavior;GO:0019228 neuronal action potential;GO:0050885 neuromuscular process controlling balance;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9ESP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60881-1", "uniprot_id": [ { "id": "SNP25_RAT", "url": "https://www.uniprot.org/uniprot/P60881", "type": "external" } ], "mass": 23315.0, "length": 206, "protein_name": "Synaptosomal-associated protein 25", "gene_name": "Snap25", "organism": "Rat", "refseq_name": "synaptosomal-associated protein 25 isoform a", "refseq_ac": [ { "id": "NP_001257504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257504", "type": "external" } ], "gene_names_uniprotkb": "Snap25; Snap", "gene_names_refseq": "SNAP-25B; SNAP-25a; Snap25", "protein_names_uniprotkb": "Synaptosomal-associated protein 25; SNAP-25; SUP; Super protein; Synaptosomal-associated 25 kDa protein", "protein_names_refseq": "SNAP-25; SUP; super protein; synaptosomal-associated 25 kDa protein; synaptosomal-associated protein 25 isoform a; synaptosomal-associated protein 25; synaptosomal-associated protein, 25 kDa", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 117 (Disease Ontology:DOID:0110683); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Down syndrome (Disease Ontology:DOID:14250); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25012); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-449836); (R-RNO-6798695); (R-RNO-888590)", "pathway_count": 9, "publication_count": 34, "publication_id_list": "10037470;10336434;10800949;10965039;11438518;11533035;11994133;12145319;12164783;12403834;12459461;12496247;1281490;15277518;16978778;18162553;18171919;19196426;23341457;26198635;26721188;28884870;32407277;37057886;37393984;38227062;39044222;39300600;8103915;8243676;8294407;8738135;9039916;9759724", "class_list": "", "function": "BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the neuromuscular junction. Publication Status: Online-Only, [RefSeq, PubMed]; Carbohydrate response element-binding protein (ChREBP) mediates decreased SNAP25 expression in islets from diabetic Goto-Kakizaki (GK) rats., [RefSeq, PubMed]; GLP-1 signaling-regulated SNAP25 is involved in improved insulin secretion in diabetic GK rats after Roux-en-Y gastric bypass surgery. Publication Status: Online-Only, [RefSeq, PubMed]; SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A., [RefSeq, PubMed]; Snap25 attenuates neuronal injury via reducing ferroptosis in acute ischemic stroke., [RefSeq, PubMed]; Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein. It is essential for regulated exocytosis in neuronal cells. Alternative transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]; t-SNARE involved in the molecular regulation of neurotransmitter release (PubMed:8103915, PubMed:8243676). May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (PubMed:12403834)., [UniProtKB, PubMed, PubMed, PubMed]; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P13795;P36974;P70557;P70558;Q8IXK3;Q96FM2;Q9BR45", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding;GO:0008289 lipid binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0098888 extrinsic component of presynaptic membrane;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:1903296 positive regulation of glutamate secretion, neurotransmission;GO:0007409 axonogenesis;GO:0007626 locomotory behavior;GO:0008306 associative learning;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 3.5, "record_id": "P60881-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M7L9-1", "uniprot_id": [ { "id": "PKP2_RAT", "url": "https://www.uniprot.org/uniprot/F1M7L9", "type": "external" } ], "mass": 90740.0, "length": 814, "protein_name": "Plakophilin-2", "gene_name": "Pkp2", "organism": "Rat", "refseq_name": "plakophilin-2", "refseq_ac": [ { "id": "NP_001093969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093969", "type": "external" } ], "gene_names_uniprotkb": "Pkp2", "gene_names_refseq": "Pkp2", "protein_names_uniprotkb": "Plakophilin-2", "protein_names_refseq": "plakophilin-2", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); arrhythmogenic right ventricular dysplasia 9 (Disease Ontology:DOID:0110077)", "pathway": " (rno:287925); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19661460;21617128;22673903;26858265", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:21617128). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (By similarity). Required to maintain gingival epithelial barrier function (By similarity). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (By similarity). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (PubMed:21617128). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (PubMed:26858265). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (PubMed:19661460, PubMed:21617128). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (By similarity). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (By similarity). Binds single-stranded DNA (ssDNA) (By similarity). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6A597", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0005080 protein kinase C binding;GO:0045296 cadherin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1900024 regulation of substrate adhesion-dependent cell spreading;GO:0045110 intermediate filament bundle assembly;GO:0048496 maintenance of animal organ identity;GO:0007267 cell-cell signaling;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1M7L9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24942-1", "uniprot_id": [ { "id": "EAA1_RAT", "url": "https://www.uniprot.org/uniprot/P24942", "type": "external" } ], "mass": 59697.0, "length": 543, "protein_name": "Excitatory amino acid transporter 1", "gene_name": "Slc1a3", "organism": "Rat", "refseq_name": "excitatory amino acid transporter 1 isoform 2", "refseq_ac": [ { "id": "NP_001276870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276870", "type": "external" } ], "gene_names_uniprotkb": "Slc1a3; Eaat1", "gene_names_refseq": "EAAT1; GLAST-1; GLAST; GluT-1; Slc1a3", "protein_names_uniprotkb": "Excitatory amino acid transporter 1; GLAST-1; GLAST; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; Solute carrier family 1 member 3", "protein_names_refseq": "excitatory amino acid transporter 1 isoform 2; excitatory amino acid transporter 1; glial glutamate transporter; glutamate transporter; glutamate/aspartate transporter; sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3", "tax_id": 10116, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); low tension glaucoma (Disease Ontology:DOID:13544); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29483); (R-RNO-210455); (R-RNO-210500); (R-RNO-9958863)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11086157;1279699;22673903;28104249;35551669;36416239;38843836;7527019;7758463;8387171;8521863", "class_list": "", "function": "EphA4/ephrinA3 reverse signaling mediated downregulation of glutamate transporter GLAST in Muller cells in an experimental glaucoma model., [RefSeq, PubMed]; Glutamate-aspartate transporter 1 attenuates oxygen-glucose deprivation-induced injury by promoting glutamate metabolism in primary cortical neurons., [RefSeq, PubMed]; Results suggest that, via astrocytes, IL-17A could promote glutamate excitotoxicity in multiple terms: by decreasing the astrocyte ability to uptake extracellular glutamate, due to a reduced gene expression of glutamate transporters (GLAST and GLT-1); by decreasing intracellular glutamate conversion into non-toxic glutamine; by potentiating glutamate exocytosis in a Ca2+ dependent manner, [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK43", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0021545 cranial nerve development;GO:0031223 auditory behavior;GO:0050885 neuromuscular process controlling balance;GO:0009611 response to wounding;GO:0006883 intracellular sodium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P24942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100100000001.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI81-1", "uniprot_id": [ { "id": "FXR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI81", "type": "external" } ], "mass": 63947.0, "length": 568, "protein_name": "RNA-binding protein FXR1", "gene_name": "Fxr1", "organism": "Rat", "refseq_name": "RNA-binding protein FXR1 isoform 4", "refseq_ac": [ { "id": "NP_001012179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012179", "type": "external" } ], "gene_names_uniprotkb": "Fxr1; Fxr1h", "gene_names_refseq": "Fxr1h; Fxr1", "protein_names_uniprotkb": "RNA-binding protein FXR1; FMR1 autosomal homolog 1", "protein_names_refseq": "RNA-binding protein FXR1 isoform 4; RNA-binding protein FXR1; rCG41429-like", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); congenital myopathy 9A (Disease Ontology:DOID:0081343); congenital myopathy 9B (Disease Ontology:DOID:0081344); fragile X syndrome (Disease Ontology:DOID:14261); glucose metabolism disease (Disease Ontology:DOID:4194); malignant pleural mesothelioma (Disease Ontology:DOID:7474)", "pathway": " (rno:361927)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;29101288;31831836;32333305", "class_list": "", "function": "In dilated cardiomyopathy, increased FXR1 expression appears to play an important role in disease progression by regulating gap junction remodeling and increasing cardiac arrhythmogenesis., [RefSeq, PubMed]; MiR-132 Regulates PTSD-like Behaviors in Rats Following Single-Prolonged Stress Through Fragile X-Related Protein 1., [RefSeq, PubMed]; RNA-binding protein FXR1 is presented in rat brain in amyloid form. Publication Status: Online-Only, [RefSeq, PubMed]; mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site. Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (By similarity). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production. Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation. Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression. Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons. Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (By similarity). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (By similarity). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (By similarity). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0043021 ribonucleoprotein complex binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0060538 skeletal muscle organ development;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0010608 post-transcriptional regulation of gene expression;GO:0032720 negative regulation of tumor necrosis factor production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XI81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97874-1", "uniprot_id": [ { "id": "GAK_RAT", "url": "https://www.uniprot.org/uniprot/P97874", "type": "external" } ], "mass": 143703.0, "length": 1305, "protein_name": "Cyclin-G-associated kinase", "gene_name": "Gak", "organism": "Rat", "refseq_name": "cyclin-G-associated kinase", "refseq_ac": [ { "id": "NP_112292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112292", "type": "external" } ], "gene_names_uniprotkb": "Gak", "gene_names_refseq": "Gak", "protein_names_uniprotkb": "Cyclin-G-associated kinase; 2.7.11.1", "protein_names_refseq": "cyclin-G-associated kinase; dnaJ homolog subfamily C member 26", "tax_id": 10116, "disease": "Parkinson's disease 19A (Disease Ontology:DOID:0060891); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:81659); (R-RNO-432722); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16262722;22673903;9013862", "class_list": "", "function": "Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Early stages of clathrin-mediated endocytosis (CME) were partially inhibited when GAK expression was knocked down; GAK plays a role in clathrin-dependent trafficking from the trans Golgi network., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030276 clathrin binding;GO:0030332 cyclin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0009913 epidermal cell differentiation;GO:0061436 establishment of skin barrier;GO:0072659 protein localization to plasma membrane;GO:0010977 negative regulation of neuron projection development;GO:0006898 receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97874-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35921-1", "uniprot_id": [ { "id": "EAA4_RAT", "url": "https://www.uniprot.org/uniprot/O35921", "type": "external" } ], "mass": 60715.0, "length": 561, "protein_name": "Excitatory amino acid transporter 4", "gene_name": "Slc1a6", "organism": "Rat", "refseq_name": "excitatory amino acid transporter 4", "refseq_ac": [ { "id": "NP_114454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114454", "type": "external" } ], "gene_names_uniprotkb": "Slc1a6; Eaat4", "gene_names_refseq": "EAAT4; Slc1a6", "protein_names_uniprotkb": "Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6", "protein_names_refseq": "excitatory amino acid transporter 4; high affinity aspartate/glutamate transporter; high-affinity neuronal glutamate transporter; sodium-dependent glutamate/aspartate transporter; solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6", "tax_id": 10116, "disease": "episodic ataxia type 6 (Disease Ontology:DOID:0050994); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:84012); (R-RNO-210500); (R-RNO-9958863)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11950769;14506254;21070388;21127051;21572047;22673903;26690923", "class_list": "", "function": "Data demonstrate that the neuronal glutamate transporter EAAT4 in Purkinje cells plays a critical role in the extrasynaptic diffusion of climbing fiber transmitters., [RefSeq, PubMed]; EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3, [RefSeq, PubMed]; EAAT4 but not EAAT2 anion channels displays voltage-dependent gating modified by glutamate, [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable)., [UniProtKB, PubMed, PubMed]; Strate-dependent gating of anion channels associated with excitatory amino acid transporter 4., [RefSeq, PubMed]; The aspartate/glutamate transporter is localized in astrocytic processes around axonal or dendritic elements of glutamatergic axo-dendritic synaptic junctions in the frontoparietal somatosensory cortex., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97683", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0001504 neurotransmitter uptake;GO:0098712 L-glutamate import across plasma membrane;GO:0140009 L-aspartate import across plasma membrane;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35921-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31596-1", "uniprot_id": [ { "id": "EAA2_RAT", "url": "https://www.uniprot.org/uniprot/P31596", "type": "external" } ], "mass": 62106.0, "length": 573, "protein_name": "Excitatory amino acid transporter 2", "gene_name": "Slc1a2", "organism": "Rat", "refseq_name": "excitatory amino acid transporter 2 isoform c", "refseq_ac": [ { "id": "NP_001289018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289018", "type": "external" } ], "gene_names_uniprotkb": "Slc1a2; Eaat2; Glt1", "gene_names_refseq": "Eaat2; Glt-1; Glt; Slc1a2", "protein_names_uniprotkb": "Excitatory amino acid transporter 2; GLT-1; GLUT-R; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2", "protein_names_refseq": "excitatory amino acid transporter 2 isoform c; excitatory amino acid transporter 2; glial glutamate transporter GLT1/V1; glial glutamate transporter GLT1/V2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; glutamate transporter 1; high affinity glucose transporter; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); developmental and epileptic encephalopathy 41 (Disease Ontology:DOID:0080442); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); opioid abuse (Disease Ontology:DOID:11206); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); Goldenhar syndrome (Disease Ontology:DOID:2907); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); colorectal cancer (Disease Ontology:DOID:9256); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:29482); (R-RNO-210455); (R-RNO-210500); (R-RNO-9958863)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10.1039/D0MO00044B;11068035;11860269;1448170;22673903;24090084;34106099;36725696;37975223;38843836;7913472;8099882", "class_list": "", "function": "HSP90beta regulates EAAT2 expression and participates in ischemia-reperfusion injury in rats., [RefSeq, PubMed]; Inhibition of mGluR5 alters BDNF/TrkB and GLT-1 expression in the prefrontal cortex and hippocampus and ameliorates PTSD-like behavior in rats. Erratum:[Psychopharmacology (Berl). 2023 Jun;240(6):1391. doi: 10.1007/s00213-023-06368-w. PMID: 37145309], [RefSeq, PubMed]; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1448170, PubMed:7913472). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:1448170). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 12, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 22, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0098656 monoatomic anion transmembrane transport;GO:0007399 nervous system development;GO:0030534 adult behavior;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 3.8, "record_id": "P31596-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89107-1", "uniprot_id": [ { "id": "DNSL3_RAT", "url": "https://www.uniprot.org/uniprot/O89107", "type": "external" } ], "mass": 35708.0, "length": 310, "protein_name": "Deoxyribonuclease gamma", "gene_name": "Dnase1l3", "organism": "Rat", "refseq_name": "deoxyribonuclease gamma precursor", "refseq_ac": [ { "id": "NP_446359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446359", "type": "external" } ], "gene_names_uniprotkb": "Dnase1l3", "gene_names_refseq": "Dnase1l3", "protein_names_uniprotkb": "Deoxyribonuclease gamma; 3.1.21.-; DNase I-like 3; DNase gamma; DNaseY; Deoxyribonuclease I-like 3", "protein_names_refseq": "DNase I-like 3; DNase gamma; DNaseY; deoxyribonuclease 1-like 3; deoxyribonuclease I-like 3; deoxyribonuclease gamma precursor; deoxyribonuclease gamma-like; deoxyribonuclease gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:116687)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15118903;15167901;29393594;7957253;9307016;9328279;9620874;9665719", "class_list": "", "function": "DNase gamma is suggested to be involved in naturally occurring apoptosis in developing nervous systems, [RefSeq, PubMed]; DNase gamma plays an important role in Fas-independent apoptotic DNA fragmentation in hepatocytes., [RefSeq, PubMed]; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (By similarity). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006309 apoptotic DNA fragmentation;GO:0006308 DNA catabolic process;GO:0010623 programmed cell death involved in cell development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O89107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62632-1", "uniprot_id": [ { "id": "EF1A2_RAT", "url": "https://www.uniprot.org/uniprot/P62632", "type": "external" } ], "mass": 50454.0, "length": 463, "protein_name": "Elongation factor 1-alpha 2", "gene_name": "Eef1a2", "organism": "Rat", "refseq_name": "elongation factor 1-alpha 2", "refseq_ac": [ { "id": "NP_036792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036792", "type": "external" } ], "gene_names_uniprotkb": "Eef1a2; Eef1al; Stnl; Stn", "gene_names_refseq": "EEF1AL; Eef1a2; Ps10; RATPS10; STN; Stnl", "protein_names_uniprotkb": "Elongation factor 1-alpha 2; 3.6.5.-; EF-1-alpha-2; Eukaryotic elongation factor 1 A-2; Statin-S1; eEF1A-2", "protein_names_refseq": "EF-1-alpha-2; Statin-like protein; eEF1A-2; elongation factor 1 A-2; elongation factor 1-alpha 2; eukaryotic elongation factor 1 A-2; statin-S1", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 38 (Disease Ontology:DOID:0070068); developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); Alzheimer's disease (Disease Ontology:DOID:10652); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (rno:24799)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "17088255;1709933;18474610;22673903;34502162", "class_list": "", "function": "Study finds that eEF1A2 stimulates formation of filopodia by increasing the cellular abundance of cytosolic and plasma membrane-bound phosphatidylinositol-4,5 bisphosphate., [RefSeq, PubMed]; There is a physical and functional relationship between eEF1A2 and PI4KIIIbeta, [RefSeq, PubMed]; Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (By similarity). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P27706", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006412 translation;GO:0051602 response to electrical stimulus;GO:0006414 translational elongation;GO:0090218 positive regulation of lipid kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62632-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI74-1", "uniprot_id": [ { "id": "EEPD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI74", "type": "external" } ], "mass": 62868.0, "length": 569, "protein_name": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "gene_name": "Eepd1", "organism": "Rat", "refseq_name": "endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001014110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014110", "type": "external" } ], "gene_names_uniprotkb": "Eepd1", "gene_names_refseq": "Eepd1; RGD1307401", "protein_names_uniprotkb": "Endonuclease/exonuclease/phosphatase family domain-containing protein 1", "protein_names_refseq": "endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 1; endonuclease/exonuclease/phosphatase family domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315500)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0010875 positive regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62651-1", "uniprot_id": [ { "id": "ECH1_RAT", "url": "https://www.uniprot.org/uniprot/Q62651", "type": "external" } ], "mass": 36172.0, "length": 327, "protein_name": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial", "gene_name": "Ech1", "organism": "Rat", "refseq_name": "delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_072116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072116", "type": "external" } ], "gene_names_uniprotkb": "Ech1", "gene_names_refseq": "Ech1; Pxel", "protein_names_uniprotkb": "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; 5.3.3.21", "protein_names_refseq": "Peroxisomal enoyl hydratase-like protein; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor; delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; enoyl CoA hydratase 1, peroxisomal; enoyl coenzyme A hydratase 1, peroxisomal; enoyl hydratase-like protein, peroxisomal", "tax_id": 10116, "disease": "", "pathway": " (rno:64526); (R-RNO-9033241); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11278886;27213235;7558027;9417087;9739087", "class_list": "", "function": "Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Enoyl-CoA delta isomerase 1 (ECI1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:11278886, PubMed:9417087). Able to isomerize 3-trans,5-cis-dienoyl-CoA (3E,5Z-dienoyl-CoA) to 2-trans,4-trans-dienoyl-CoA (2E,4E-dienoyl-CoA), a crucial step in the beta-oxidation of unsaturated fatty acids with double bonds at odd position (PubMed:11278886, PubMed:9417087). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Isomerization of 3-trans,5-cis-dienoyl-CoA (3E,5Z-dienoyl-CoA) to 2-trans,4-trans-dienoyl-CoA (2E,4E-dienoyl-CoA), a crucial step in the beta-oxidation of unsaturated fatty acids with double bonds at odd position., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0051750 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62651-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62780-1", "uniprot_id": [ { "id": "DDX46_RAT", "url": "https://www.uniprot.org/uniprot/Q62780", "type": "external" } ], "mass": 117385.0, "length": 1032, "protein_name": "Probable ATP-dependent RNA helicase DDX46", "gene_name": "Ddx46", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DDX46 isoform 1", "refseq_ac": [ { "id": "NP_620798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620798", "type": "external" } ], "gene_names_uniprotkb": "Ddx46; Hel117", "gene_names_refseq": "Ddx46", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX46; 3.6.4.13; DEAD box protein 46; Helicase of 117.4 kDa", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 46; DEAD box protein 46; helicase of 117.4 kDa; probable ATP-dependent RNA helicase DDX46 isoform 1; probable ATP-dependent RNA helicase DDX46", "tax_id": 10116, "disease": "", "pathway": " (rno:245957); (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "16641100;22673903;7797571", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0015030 Cajal body;GO:0005684 U2-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62780-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6V0-1", "uniprot_id": [ { "id": "G6PI_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6V0", "type": "external" } ], "mass": 62827.0, "length": 558, "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "Gpi", "organism": "Rat", "refseq_name": "glucose-6-phosphate isomerase", "refseq_ac": [ { "id": "NP_997475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997475", "type": "external" } ], "gene_names_uniprotkb": "Gpi", "gene_names_refseq": "Amf; Gpi1; Gpi; Nlk; Pgi; Phi", "protein_names_uniprotkb": "Glucose-6-phosphate isomerase; 5.1.3.-; 5.3.1.9; AMF; Autocrine motility factor; D-hexose-6-phosphate anomerase; GPI; Glucose-6-phosphate C2-epimerase; NLK; Neuroleukin; PGI; PHI; Phosphoglucose isomerase; Phosphohexose isomerase", "protein_names_refseq": "autocrine motility factor; glucose-6-phosphate isomerase", "tax_id": 10116, "disease": "congenital nonspherocytic hemolytic anemia 4 (Disease Ontology:DOID:0051005); intellectual disability (Disease Ontology:DOID:1059); heart disease (Disease Ontology:DOID:114); Parkinson's disease (Disease Ontology:DOID:14330); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); neuromuscular disease (Disease Ontology:DOID:440); congenital hemolytic anemia (Disease Ontology:DOID:589); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:292804); (R-RNO-5628897); (R-RNO-6798695); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "19343716;22673903;26459914;2709006", "class_list": "", "function": "Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P. In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3 Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the glucose phosphate isomerase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0004347 glucose-6-phosphate isomerase activity;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0007611 learning or memory;GO:0043066 negative regulation of apoptotic process;GO:0010595 positive regulation of endothelial cell migration;GO:0006094 gluconeogenesis;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P6V0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z30-1", "uniprot_id": [ { "id": "PPM1E_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z30", "type": "external" } ], "mass": 83439.0, "length": 750, "protein_name": "Protein phosphatase 1E", "gene_name": "Ppm1e", "organism": "Rat", "refseq_name": "protein phosphatase 1E", "refseq_ac": [ { "id": "NP_942068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942068", "type": "external" } ], "gene_names_uniprotkb": "Ppm1e; Camkn", "gene_names_refseq": "Ppm1e", "protein_names_uniprotkb": "Protein phosphatase 1E; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase N; CaMKN; CaMKP-N; CaMKP-nucleus; Partner of PIX 1; Partner of PIX-alpha; Partner of PIXA", "protein_names_refseq": "ca(2+)/calmodulin-dependent protein kinase phosphatase N; caMKN; caMKP-N; caMKP-nucleus; calmodulin-dependent protein kinase phosphatase N; partner of PIX 1; partner of PIX-alpha; partner of PIXA; protein phosphatase 1E (PP2C domain containing); protein phosphatase 1E", "tax_id": 10116, "disease": "", "pathway": " (rno:360593)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11726284;12807427;15680915;16269004;22673903", "class_list": "", "function": "CaM kinase phosphatase N is involved in the regulation of not only CaM kinase IV but also CaM kinases II and I., [RefSeq, PubMed]; CaM kinase phosphatase N occurs inside the cellular nucleus of PC-12 cells [Ppm1e]., [RefSeq, PubMed]; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Inactivates multifunctional CaM kinases. Dephosphorylates PRKAA2 (By similarity)., [UniProtKB, PubMed]; The results suggest that CaMKP regulates the phosphorylation level of GAPDH in the CaMKP-GAPDH complex by dephosphorylating and deactivating CaMKs that are responsible for the phosphorylation of GAPDH., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0006469 negative regulation of protein kinase activity;GO:0071466 cellular response to xenobiotic stimulus;GO:0071222 cellular response to lipopolysaccharide;GO:0051496 positive regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80Z30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2P6-1", "uniprot_id": [ { "id": "SNP29_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2P6", "type": "external" } ], "mass": 29071.0, "length": 257, "protein_name": "Synaptosomal-associated protein 29", "gene_name": "Snap29", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snap29", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptosomal-associated protein 29; Golgi SNARE of 32 kDa; Gs32; SNAP-29; Soluble 29 kDa NSF attachment protein; Vesicle-membrane fusion protein SNAP-29", "protein_names_refseq": "", "tax_id": 10116, "disease": "CEDNIK syndrome (Disease Ontology:DOID:0060337); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413)", "pathway": " (R-RNO-6798695); (R-RNO-6811438)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "27191843;29393594;30221662;9880331", "class_list": "", "function": "SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z2P6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52873-1", "uniprot_id": [ { "id": "PYC_RAT", "url": "https://www.uniprot.org/uniprot/P52873", "type": "external" } ], "mass": 129777.0, "length": 1178, "protein_name": "Pyruvate carboxylase, mitochondrial", "gene_name": "Pc", "organism": "Rat", "refseq_name": "pyruvate carboxylase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036876", "type": "external" } ], "gene_names_uniprotkb": "Pc", "gene_names_refseq": "Pcx; Pc", "protein_names_uniprotkb": "Pyruvate carboxylase, mitochondrial; 6.4.1.1; PCB; Pyruvic carboxylase", "protein_names_refseq": "PCB; pyruvate carboxylase, mitochondrial precursor; pyruvate carboxylase, mitochondrial; pyruvic carboxylase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); pyruvate carboxylase deficiency disease (Disease Ontology:DOID:3651)", "pathway": " (rno:25104); (R-RNO-196780); (R-RNO-70263); (R-RNO-70268)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "20001964;21933451;22673903;23357280;25054881;3178228;8522203;8687410", "class_list": "", "function": "A carbohydrate response element in the distal gene promoter contributes to the glucose-mediated expression of pyruvate carboxylase. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB, UniProtKB]; Data indicate that glucose-mediated transcriptional activation of the pyruvate carboxylase (PC) gene is regulated by transcription factors. Publication Status: Online-Only, [RefSeq, PubMed]; Pyruvate carboxylase and fatty acid synthase were knocked down in insulin cells. Insulin secretion, phospholipid and cholesterol esters were lowered., [RefSeq, PubMed]; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKM0;Q64555", "ec_number_list": [ { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0009374 biotin binding;GO:0004736 pyruvate carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0019074 viral RNA genome packaging;GO:0006629 lipid metabolic process;GO:0010629 negative regulation of gene expression;GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P52873-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63424-1", "uniprot_id": [ { "id": "S15A2_RAT", "url": "https://www.uniprot.org/uniprot/Q63424", "type": "external" } ], "mass": 81320.0, "length": 729, "protein_name": "Solute carrier family 15 member 2", "gene_name": "Slc15a2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc15a2; Pept2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter, kidney isoform; Peptide transporter 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:60577)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15056281;22673903;26320580;34433568;8639691;9915809", "class_list": "", "function": "Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:8639691). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (PubMed:8639691). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (By similarity). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:15056281). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015333 peptide:proton symporter activity;GO:0015334 high-affinity oligopeptide transmembrane transporter activity;GO:0042937 tripeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0015031 protein transport;GO:0070293 renal absorption;GO:0006857 oligopeptide transport;GO:0140206 dipeptide import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63424-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI66-1", "uniprot_id": [ { "id": "S4A4_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI66", "type": "external" } ], "mass": 121343.0, "length": 1079, "protein_name": "Electrogenic sodium bicarbonate cotransporter 1", "gene_name": "Slc4a4", "organism": "Rat", "refseq_name": "electrogenic sodium bicarbonate cotransporter 1", "refseq_ac": [ { "id": "NP_445876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445876", "type": "external" } ], "gene_names_uniprotkb": "Slc4a4; Nbc1; Nbce1; Nbc; Rnbc1", "gene_names_refseq": "HHNMC; HNBC1; KNBC; NBC2; Nbc1; Nbc4; PNBC; SLC4A5; Slc4a4", "protein_names_uniprotkb": "Electrogenic sodium bicarbonate cotransporter 1; NBC-like protein; Na(+)/HCO3(-) cotransporter; Sodium bicarbonate cotransporter; Solute carrier family 4 member 4", "protein_names_refseq": "NBC-like protein; Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; electrogenic sodium bicarbonate cotransporter 1; sodium bicarbonate cotransporter; solute carrier family 4 (anion exchanger), member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4", "tax_id": 10116, "disease": "proximal renal tubular acidosis-ocular anomaly syndrome (Disease Ontology:DOID:0061195); hypertension (Disease Ontology:DOID:10763); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:84484); (R-RNO-425381)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10648705;10837348;11592950;11703600;12444017;12604466;15329059;15781297;21454685;22673903;30526387;30615862;34231059;9486238;9841505", "class_list": "", "function": "Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate cardiac dysfunction after myocardial infarction., [RefSeq, PubMed]; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NBCe1 inhibition limits cell death, improves myocardial post-ischemic contractility and mitochondrial state through calcineurin/P38MAPK/HSP27-dependent pathways., [RefSeq, PubMed]; The sodium bicarbonate cotransporter NBCe1-B is expressed in rat and human thyroid, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35422;O54815;Q9JJ32;Q9QXH6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0015293 symporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0045821 positive regulation of glycolytic process;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9JI66-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50116-1", "uniprot_id": [ { "id": "S10A9_RAT", "url": "https://www.uniprot.org/uniprot/P50116", "type": "external" } ], "mass": 13145.0, "length": 113, "protein_name": "Protein S100-A9", "gene_name": "S100a9", "organism": "Rat", "refseq_name": "protein S100-A9", "refseq_ac": [ { "id": "NP_446039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446039", "type": "external" } ], "gene_names_uniprotkb": "S100a9; Mrp14", "gene_names_refseq": "Mrp14; S100a9", "protein_names_uniprotkb": "Protein S100-A9; Calgranulin-B; MRP-14; Migration inhibitory factor-related protein 14; Myeloid-related protein 14; S100 calcium-binding protein A9; p14", "protein_names_refseq": "MRP-14; S100 calcium binding protein A9 (calgranulin B); calgranulin-B; intracellular calcium-binding protein (MRP14); migration inhibitory factor-related protein 14; myeloid-related protein 14; p14; protein S100-A9", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); hepatocellular carcinoma (Disease Ontology:DOID:684); myocarditis (Disease Ontology:DOID:820)", "pathway": " (rno:94195); (R-RNO-3000471); (R-RNO-5668599); (R-RNO-5686938); (R-RNO-6798695); (R-RNO-6799990)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "15153104;21487906;29393594;36299239;37846082;38324770;38697446;8343166;9570842", "class_list": "", "function": "Identification of S100A8/A9 involved in thromboangiitis obliterans development using tandem mass tags-labeled quantitative proteomics analysis., [RefSeq, PubMed]; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response (PubMed:15153104, PubMed:21487906). It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism (By similarity). Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions (By similarity). The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase (By similarity). Also participates in regulatory T-cell differentiation together with CD69. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX (By similarity). The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities (PubMed:21487906). Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration (By similarity). Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER) (By similarity). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade (By similarity). Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth (By similarity). Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3 (By similarity). Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK (By similarity). Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants (By similarity). The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, NXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription., [RefSeq, PubMed]; The Surprising Nonlinear Effects of S100A9 Proteins in the Retina., [RefSeq, PubMed]; Transcriptomic Analysis of Retinal Gene in Experimental Retinal Detachment Rats and Exploration of S100A9 and TLR4 in Human Vitreous., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q761U7", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0006417 regulation of translation;GO:0010043 response to zinc ion;GO:0010976 positive regulation of neuron projection development;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50116-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M821-1", "uniprot_id": [ { "id": "PPM1H_RAT", "url": "https://www.uniprot.org/uniprot/Q5M821", "type": "external" } ], "mass": 56380.0, "length": 513, "protein_name": "Protein phosphatase 1H", "gene_name": "Ppm1h", "organism": "Rat", "refseq_name": "protein phosphatase 1H", "refseq_ac": [ { "id": "NP_001258008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258008", "type": "external" } ], "gene_names_uniprotkb": "Ppm1h", "gene_names_refseq": "Ppm1h", "protein_names_uniprotkb": "Protein phosphatase 1H; 3.1.3.16", "protein_names_refseq": "protein phosphatase 1H (PP2C domain containing); protein phosphatase 1H", "tax_id": 10116, "disease": "", "pathway": " (rno:314897)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0042802 identical protein binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M821-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZA2-1", "uniprot_id": [ { "id": "PDC6I_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZA2", "type": "external" } ], "mass": 96631.0, "length": 873, "protein_name": "Programmed cell death 6-interacting protein", "gene_name": "Pdcd6ip", "organism": "Rat", "refseq_name": "programmed cell death 6-interacting protein isoform X1", "refseq_ac": [ { "id": "XP_006244059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006244059", "type": "external" } ], "gene_names_uniprotkb": "Pdcd6ip; Aip1", "gene_names_refseq": "AIP1; Alix; Pdcd6ip; RGD1561176", "protein_names_uniprotkb": "Programmed cell death 6-interacting protein; ALG-2-interacting protein 1", "protein_names_refseq": "programmed cell death 6-interacting protein isoform X1", "tax_id": 10116, "disease": "primary autosomal recessive microcephaly 29 (Disease Ontology:DOID:0051040)", "pathway": " (rno:501083); (R-RNO-5213460); (R-RNO-5675482)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10858458;19343716", "class_list": "", "function": "Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0048306 calcium-dependent protein binding;GO:0031871 proteinase activated receptor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005923 bicellular tight junction;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0039702 viral budding via host ESCRT complex;GO:0090559 regulation of membrane permeability;GO:0015031 protein transport;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFB6-1", "uniprot_id": [ { "id": "PRRT2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFB6", "type": "external" } ], "mass": 35821.0, "length": 344, "protein_name": "Proline-rich transmembrane protein 2", "gene_name": "Prrt2", "organism": "Rat", "refseq_name": "proline-rich transmembrane protein 2", "refseq_ac": [ { "id": "NP_001263399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263399", "type": "external" } ], "gene_names_uniprotkb": "Prrt2", "gene_names_refseq": "DSPB3; Prrt2; RGD1564195", "protein_names_uniprotkb": "Proline-rich transmembrane protein 2; DSPB3; Dispanin subfamily B member 3", "protein_names_refseq": "Dispanin subfamily B member 3; proline-rich transmembrane protein 2", "tax_id": 10116, "disease": "benign familial infantile seizures 2 (Disease Ontology:DOID:0081115); episodic kinesigenic dyskinesia 1 (Disease Ontology:DOID:0090053)", "pathway": " (rno:361651)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22632720;22673903;26797119;27172900;30347267", "class_list": "", "function": "As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation., [UniProtKB, UniProtKB]; PRRT2 mutations have roles in neuronal dysfunction and neurodevelopmental defects, [RefSeq, PubMed]; Study shows that proline-rich transmembrane protein 2 (PRRT2) deficiency induces paroxysmal kinesigenic dyskinesia by influencing synaptic function in the primary motor cortex of rats. Results provide new insights into the function of PRRT2 in synaptic transmission and movement control., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043197 dendritic spine;GO:0043679 axon terminus", "go_biological_process": "GO:0035544 negative regulation of SNARE complex assembly;GO:0050884 neuromuscular process controlling posture;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:1905513 negative regulation of short-term synaptic potentiation;GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZFB6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63633-1", "uniprot_id": [ { "id": "S12A5_RAT", "url": "https://www.uniprot.org/uniprot/Q63633", "type": "external" } ], "mass": 126247.0, "length": 1139, "protein_name": "Solute carrier family 12 member 5", "gene_name": "Slc12a5", "organism": "Rat", "refseq_name": "solute carrier family 12 member 5 isoform 2", "refseq_ac": [ { "id": "NP_599190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599190", "type": "external" } ], "gene_names_uniprotkb": "Slc12a5; Kcc2", "gene_names_refseq": "Kcc2; Slc12a5", "protein_names_uniprotkb": "Solute carrier family 12 member 5; Electroneutral potassium-chloride cotransporter 2; Furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; Neuronal K-Cl cotransporter; rKCC2", "protein_names_refseq": "K-Cl cotransporter 2; electroneutral potassium-chloride cotransporter 2; furosemide-sensitive K-Cl cotransporter; neuronal K-Cl cotransporter; neuronal-specific K-Cl cotransporter; solute carrier family 12 (potassium-chloride transporter), member 5; solute carrier family 12 member 5 isoform 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 34 (Disease Ontology:DOID:0080460); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:171373); (R-RNO-426117)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10.1039/D0MO00044B;11551954;17715129;22345354;22544747;22673903;34106099;36567653;37005931;37830575;38191090;38843836;38892438;8663311;9930699", "class_list": "", "function": "Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:11551954). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (PubMed:9930699). Involved in the regulation of dendritic spine formation and maturation (PubMed:22345354)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF., [RefSeq, PubMed]; Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Suppression of HCN channels in the spinal dorsal horn restores KCC2 expression and attenuates diabetic neuropathic pain., [RefSeq, PubMed]; The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A7Y821", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0008519 ammonium channel activity;GO:0015108 chloride transmembrane transporter activity;GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043198 dendritic shaft", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0006811 monoatomic ion transport;GO:0007612 learning;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q63633-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54963-1", "uniprot_id": [ { "id": "REST_RAT", "url": "https://www.uniprot.org/uniprot/O54963", "type": "external" } ], "mass": 117126.0, "length": 1069, "protein_name": "RE1-silencing transcription factor", "gene_name": "Rest", "organism": "Rat", "refseq_name": "RE1-silencing transcription factor", "refseq_ac": [ { "id": "NP_113976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113976", "type": "external" } ], "gene_names_uniprotkb": "Rest; Nrsf", "gene_names_refseq": "Nrsf; Rest", "protein_names_uniprotkb": "RE1-silencing transcription factor; Neural-restrictive silencer factor", "protein_names_refseq": "RE1-silencing transcription factor; neural-restrictive silencer factor; zinc finger transcription factor REST protein", "tax_id": 10116, "disease": "gingival fibromatosis 5 (Disease Ontology:DOID:0080280); autosomal dominant nonsyndromic deafness 27 (Disease Ontology:DOID:0110556); alcohol use disorder (Disease Ontology:DOID:1574); nephroblastoma (Disease Ontology:DOID:2154)", "pathway": " (rno:83618); (R-RNO-3214815)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10490617;12657670;22371606;22673903;22960932;25108103;31403159;32151715;33185010;38641413;9454838", "class_list": "", "function": "Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (By similarity). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 6 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST., [RefSeq, PubMed]; Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats., [RefSeq, PubMed]; The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy., [RefSeq, PubMed]; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (By similarity). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 6 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 6, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (By similarity). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult hippocampal neural stem cells and preventing premature differentiation into mature neurons (By similarity). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (PubMed:22960932). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (By similarity). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (PubMed:12657670, PubMed:22371606). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (PubMed:25108103)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54964", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex", "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O54963-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64375-1", "uniprot_id": [ { "id": "SC65_RAT", "url": "https://www.uniprot.org/uniprot/Q64375", "type": "external" } ], "mass": 51104.0, "length": 443, "protein_name": "Endoplasmic reticulum protein SC65", "gene_name": "P3h4", "organism": "Rat", "refseq_name": "endoplasmic reticulum protein SC65 precursor", "refseq_ac": [ { "id": "NP_067592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067592", "type": "external" } ], "gene_names_uniprotkb": "P3h4; Leprel4; Sc65", "gene_names_refseq": "Leprel4; P3h4; Sc65", "protein_names_uniprotkb": "Endoplasmic reticulum protein SC65; Leprecan-like protein 4; Prolyl 3-hydroxylase family member 4; Synaptonemal complex protein SC65", "protein_names_refseq": "SC65 synaptonemal complex protein; endoplasmic reticulum protein SC65 precursor; endoplasmic reticulum protein SC65; leprecan-like 4; leprecan-like protein 4; prolyl 3-hydroxylase family member 4 (non-enzymatic); synaptonemal complex protein SC65", "tax_id": 10116, "disease": "", "pathway": " (rno:59101)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1363622", "class_list": "", "function": "Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A096MJK4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:1902494 catalytic complex;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0046849 bone remodeling;GO:0032964 collagen biosynthetic process;GO:0017185 peptidyl-lysine hydroxylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64375-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PT23-1", "uniprot_id": [ { "id": "S38AA_RAT", "url": "https://www.uniprot.org/uniprot/E9PT23", "type": "external" } ], "mass": 118797.0, "length": 1099, "protein_name": "Solute carrier family 38 member 10", "gene_name": "Slc38a10", "organism": "Rat", "refseq_name": "solute carrier family 38 member 10 isoform X5", "refseq_ac": [ { "id": "XP_221195", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_221195", "type": "external" } ], "gene_names_uniprotkb": "Slc38a10", "gene_names_refseq": "RGD1306356; Slc38a10", "protein_names_uniprotkb": "Solute carrier family 38 member 10; Amino acid transporter SLC38A10", "protein_names_refseq": "solute carrier family 38 member 10 isoform X5", "tax_id": 10116, "disease": "", "pathway": " (rno:303740)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18418736;22673903", "class_list": "", "function": "Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0008324 monoatomic cation transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0060348 bone development;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E9PT23-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PT37-1", "uniprot_id": [ { "id": "RBM20_RAT", "url": "https://www.uniprot.org/uniprot/E9PT37", "type": "external" } ], "mass": 130760.0, "length": 1207, "protein_name": "RNA-binding protein 20", "gene_name": "Rbm20", "organism": "Rat", "refseq_name": "RNA-binding protein 20", "refseq_ac": [ { "id": "NP_001101081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101081", "type": "external" } ], "gene_names_uniprotkb": "Rbm20", "gene_names_refseq": "Rbm20", "protein_names_uniprotkb": "RNA-binding protein 20; RNA-binding motif protein 20", "protein_names_refseq": "RNA-binding protein 20; probable RNA-binding protein 20", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); dilated cardiomyopathy 1DD (Disease Ontology:DOID:0110447); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (rno:309544)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "22466703;22673903;23307558;24367651;24960161;25573899;27289039;31221019;31717392;33805770;35394688;35762193", "class_list": "", "function": "Combined transcriptome-wide crosslinking immunoprecipitation, RNA-seq, and quantitative proteomics in cell culture and hearts to examine how RBM20 regulates alternative splicing in the heart, [RefSeq, PubMed]; Deep sequencing of the human and rat cardiac transcriptome revealed an RBM20-dependent regulation of alternative splicing, [RefSeq, PubMed]; Megaesophagus Is a Major Pathological Condition in Rats With a Large Deletion in the Rbm20 Gene., [RefSeq, PubMed]; New insights on Rbm20 function and how its malfunction leads to cardiomyopathy Publication Status: Online-Only, [RefSeq, PubMed]; RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis., [RefSeq, PubMed]; RBM20 specifically regulates the inclusion of exon 9* in CACNA1C mRNA, resulting in reduced cell-surface membrane expression of l-channels in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; RBM20-Mediated Pre-mRNA Splicing Has Muscle-Specificity and Differential Hormonal Responses between Muscles and in Muscle Cell Cultures. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899, PubMed:27289039, PubMed:33805770, PubMed:35394688). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:23307558, PubMed:24367651, PubMed:24960161, PubMed:25573899, PubMed:33805770, PubMed:35394688). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (By similarity). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (PubMed:27289039)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Rbm20 ablation is associated with changes in the expression of titin-interacting and metabolic proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C1IEE3", "ec_number_list": [], "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0043484 regulation of RNA splicing;GO:0048024 regulation of mRNA splicing, via spliceosome;GO:0060914 heart formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E9PT37-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N3-1", "uniprot_id": [ { "id": "PEX5R_RAT", "url": "https://www.uniprot.org/uniprot/Q925N3", "type": "external" } ], "mass": 66872.0, "length": 602, "protein_name": "PEX5-related protein", "gene_name": "Pex5l", "organism": "Rat", "refseq_name": "PEX5-related protein isoform 1", "refseq_ac": [ { "id": "NP_775175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775175", "type": "external" } ], "gene_names_uniprotkb": "Pex5l; Pex2; Pex5r; Trip8b", "gene_names_refseq": "Pex2; Pex5l; TRIP8b; Trjip8b", "protein_names_uniprotkb": "PEX5-related protein; PEX5-like protein; Peroxin-5-related protein; Pex5Rp; TPR-containing Rab8b-interacting protein; TRIP8b; Tetratricopeptide repeat-containing Rab8b-interacting protein", "protein_names_refseq": "PEX5-like protein; PEX5-related protein isoform 1; PEX5-related protein; TPR-containing Rab8b-interacting protein; peroxin 2; peroxin-5-related protein; pex5Rp; tetratricopeptide repeat-containing Rab8b-interacting protein", "tax_id": 10116, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477)", "pathway": " (rno:286937)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11278749;18620529;19555650;21795621;22363812;22673903;24451387;31492750", "class_list": "", "function": "A role of TRIP8b in receptor-mediated endocytosis., [RefSeq, PubMed]; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyperpolarization current expression was high in corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits., [RefSeq, PubMed]; Loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis., [RefSeq, PubMed]; Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process, [RefSeq, PubMed]; TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0000268 peroxisome targeting sequence binding;GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity", "go_cellular_component": "GO:0051286 cell tip;GO:0005737 cytoplasm;GO:0005778 peroxisomal membrane;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0045055 regulated exocytosis;GO:0051461 positive regulation of corticotropin secretion;GO:0045185 maintenance of protein location;GO:0016560 protein import into peroxisome matrix, docking", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q925N3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTR8-1", "uniprot_id": [ { "id": "PHLP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTR8", "type": "external" } ], "mass": 183364.0, "length": 1696, "protein_name": "PH domain leucine-rich repeat protein phosphatase 1", "gene_name": "Phlpp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phlpp1; Phlpp; Plekhe1; Scop", "gene_names_refseq": "", "protein_names_uniprotkb": "PH domain leucine-rich repeat protein phosphatase 1; 3.1.3.16; PH domain-containing family E member 1; Pleckstrin homology domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:59265); (R-RNO-199418)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10570941;12594205;20089132;20819118", "class_list": "", "function": "Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:20819118). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons while isoform 1 may promote Akt and PKC activation and inhibit ERK signaling (PubMed:20819118). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (By similarity). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (By similarity). Inhibits cancer cell proliferation and may act as a tumor suppressor (By similarity). Dephosphorylates RAF1 inhibiting its kinase activity (By similarity). May act as a negative regulator of K-Ras signaling in membrane rafts (PubMed:12594205). Involved in the hippocampus-dependent long-term memory formation (By similarity). Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity). Involved in development and function of regulatory T-cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005634 nucleus", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:1902532 negative regulation of intracellular signal transduction;GO:0035556 intracellular signal transduction;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTR8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LNI5-1", "uniprot_id": [ { "id": "PPM1G_RAT", "url": "https://www.uniprot.org/uniprot/F1LNI5", "type": "external" } ], "mass": 58743.0, "length": 542, "protein_name": "Protein phosphatase 1G", "gene_name": "Ppm1g", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppm1g", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein phosphatase 1G; 3.1.3.16; Protein phosphatase magnesium-dependent 1 gamma", "protein_names_refseq": "", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16639714", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006470 protein dephosphorylation;GO:0035970 peptidyl-threonine dephosphorylation;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LNI5-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88588-1", "uniprot_id": [ { "id": "PACS1_RAT", "url": "https://www.uniprot.org/uniprot/O88588", "type": "external" } ], "mass": 104700.0, "length": 961, "protein_name": "Phosphofurin acidic cluster sorting protein 1", "gene_name": "Pacs1", "organism": "Rat", "refseq_name": "phosphofurin acidic cluster sorting protein 1", "refseq_ac": [ { "id": "NP_599233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599233", "type": "external" } ], "gene_names_uniprotkb": "Pacs1", "gene_names_refseq": "Pacs-1; Pacs1", "protein_names_uniprotkb": "Phosphofurin acidic cluster sorting protein 1; PACS-1", "protein_names_refseq": "cytosolic sorting protein PACS-1; phosphofurin acidic cluster sorting protein 1", "tax_id": 10116, "disease": "Schuurs-Hoeijmakers Syndrome (Disease Ontology:DOID:0070047)", "pathway": " (rno:171444)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18683930;22673903;38843836;9695949", "class_list": "", "function": "Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88589", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0030137 COPI-coated vesicle", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0072659 protein localization to plasma membrane;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88588-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97943-1", "uniprot_id": [ { "id": "SCRB1_RAT", "url": "https://www.uniprot.org/uniprot/P97943", "type": "external" } ], "mass": 56957.0, "length": 509, "protein_name": "Scavenger receptor class B member 1", "gene_name": "Scarb1", "organism": "Rat", "refseq_name": "scavenger receptor class B member 1", "refseq_ac": [ { "id": "NP_113729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113729", "type": "external" } ], "gene_names_uniprotkb": "Scarb1", "gene_names_refseq": "Cd36l1; SR-B1; Scarb1; Srb1", "protein_names_uniprotkb": "Scavenger receptor class B member 1; SR-BI; SRB1", "protein_names_refseq": "CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; SR-BI; scavanger receptor class B type 1; scavenger receptor class B member 1; scavenger receptor class B type I", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); sensorineural hearing loss (Disease Ontology:DOID:10003); morbid obesity (Disease Ontology:DOID:11981); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:25073); (R-RNO-3000471); (R-RNO-8964011)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10829064;12016218;27881715;27934803;28669731;31344978;9177301;9291126", "class_list": "", "function": "Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized HDL-C levels, possibly by regulating pathways involved in HDL synthesis and degradation, independent of hepatic SR-B1 in this glucose-intolerant obese rat mode, [RefSeq, PubMed]; Model recombinant HDL (rHDL) particles formed in vitro with S1P incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P did not, suggesting that S1P transported in HDL can selectively activate S1PR1., [RefSeq, PubMed]; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity., [UniProtKB, UniProtKB]; The molecular docking revealed that S-allyl-mercapto-glutathione interacting with Colec12, MARCO (class A), and SCARB1 (class B) scavenger receptors in in vitro tests demonstrates a direct stimulation of immunoglobulin secretion by S-allylmercaptoglutathione (GSSA) in CD19+ B lymphocytes. Publication Status: Online-Only, [RefSeq, PubMed]; The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0005044 scavenger receptor activity;GO:0005319 lipid transporter activity;GO:0034185 apolipoprotein binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1902070 positive regulation of sphingolipid mediated signaling pathway;GO:0006869 lipid transport;GO:0042311 vasodilation;GO:0015914 phospholipid transport;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97943-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56222-1", "uniprot_id": [ { "id": "PO3F2_RAT", "url": "https://www.uniprot.org/uniprot/P56222", "type": "external" } ], "mass": 47172.0, "length": 445, "protein_name": "POU domain, class 3, transcription factor 2", "gene_name": "Pou3f2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pou3f2; Brn2; Otf7", "gene_names_refseq": "", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 2; Brain-2; Brain-specific homeobox/POU domain protein 2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; OTF-7; Oct-7; Octamer-binding protein 7; Octamer-binding transcription factor 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29588)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8276233", "class_list": "", "function": "Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (PubMed:8276233). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56222-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTV0-1", "uniprot_id": [ { "id": "SEC12_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTV0", "type": "external" } ], "mass": 45357.0, "length": 417, "protein_name": "Guanine nucleotide-exchange factor SEC12", "gene_name": "Preb", "organism": "Rat", "refseq_name": "guanine nucleotide-exchange factor SEC12", "refseq_ac": [ { "id": "NP_001164179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164179", "type": "external" } ], "gene_names_uniprotkb": "Preb; Sec12", "gene_names_refseq": "Preb; mSec12", "protein_names_uniprotkb": "Guanine nucleotide-exchange factor SEC12; Mammalian guanine nucleotide exchange factor Sec12; Prolactin regulatory element-binding protein; mSec12", "protein_names_refseq": "guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor Sec12; mammalian guanine nucleotide exchange factor mSec12; prolactin regulatory element-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:58842); (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10194769;11422940;16752178;19426980;20643408;20960102", "class_list": "", "function": "Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:11422940). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:11422940)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PREB can function as a transcriptional regulator of prolactin promoter activity and might be involved in TRH-induced PRL gene transcription, [RefSeq, PubMed]; PREB may contribute to the regulation of insulin gene transcription and insulin secretion in response to glucose stimulation., [RefSeq, PubMed]; PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells, [RefSeq, PubMed]; The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells., [RefSeq, PubMed]; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYS1", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0051020 GTPase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MU5-1", "uniprot_id": [ { "id": "SPAT6_RAT", "url": "https://www.uniprot.org/uniprot/Q99MU5", "type": "external" } ], "mass": 56019.0, "length": 488, "protein_name": "Spermatogenesis-associated protein 6", "gene_name": "Spata6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Spata6; Hash; Srf1", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermatogenesis-associated protein 6; Kinesin-related protein; Spermatogenesis-related factor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11735130;12771232;22673903", "class_list": "", "function": "Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN12;Q9EQU0", "ec_number_list": [], "go_molecular_function": "GO:0032027 myosin light chain binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031514 motile cilium;GO:0120212 sperm head-tail coupling apparatus", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0044458 motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q99MU5-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55068-1", "uniprot_id": [ { "id": "PGCB_RAT", "url": "https://www.uniprot.org/uniprot/P55068", "type": "external" } ], "mass": 96057.0, "length": 883, "protein_name": "Brevican core protein", "gene_name": "Bcan", "organism": "Rat", "refseq_name": "brevican core protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001028837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028837", "type": "external" } ], "gene_names_uniprotkb": "Bcan; Behab; LOC100910284", "gene_names_refseq": "ALPBRE; BEHAB; Bcan", "protein_names_uniprotkb": "Brevican core protein; BEHAB; Brain-enriched hyaluronan-binding protein", "protein_names_refseq": "brain-enriched hyaluronan-binding protein; brevican (brain specific proteoglycan in the aggrecan family); brevican core protein isoform 1 precursor; brevican core protein-like; brevican core protein", "tax_id": 10116, "disease": "junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); epithelial recurrent erosion dystrophy (Disease Ontology:DOID:0070337); retinitis pigmentosa (Disease Ontology:DOID:10584); high grade glioma (Disease Ontology:DOID:3070); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:25393); (R-RNO-1474228); (R-RNO-1971475); (R-RNO-2022870); (R-RNO-2022923); (R-RNO-2024101); (R-RNO-3000178)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "22673903;25052349;38843836;7488217;7512973;7592978;9294172", "class_list": "", "function": "High Brevican expression is associated with glioma tumor aggressiveness., [RefSeq, PubMed]; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62860;Q63040;Q63513", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0021766 hippocampus development;GO:0007160 cell-matrix adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0048168 regulation of neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P55068-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09812-1", "uniprot_id": [ { "id": "PYGM_RAT", "url": "https://www.uniprot.org/uniprot/P09812", "type": "external" } ], "mass": 97273.0, "length": 842, "protein_name": "Glycogen phosphorylase, muscle form", "gene_name": "Pygm", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pygm", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycogen phosphorylase, muscle form; 2.4.1.1; Myophosphorylase", "protein_names_refseq": "", "tax_id": 10116, "disease": "cholestasis (Disease Ontology:DOID:13580); glycogen storage disease V (Disease Ontology:DOID:2746); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:24701); (R-RNO-70221)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22673903;2424788;34502162;3840433;7916624", "class_list": "glycogene;glycosyltransferase", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016208 AMP binding;GO:0030246 carbohydrate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0001666 response to hypoxia;GO:0005977 glycogen metabolic process;GO:0006874 intracellular calcium ion homeostasis;GO:0051591 response to cAMP;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P09812-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0100000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55007-4", "uniprot_id": [ { "id": "RGPA1_RAT", "url": "https://www.uniprot.org/uniprot/O55007", "type": "external" } ], "mass": 229447.0, "length": 2035, "protein_name": "Ral GTPase-activating protein subunit alpha-1", "gene_name": "Ralgapa1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ralgapa1; Garnl1; Tulip1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; GTPase-activating RapGAP domain-like 1; Tuberin-like protein 1; p240", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:56785); (R-RNO-9013407)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19520869;22673903", "class_list": "", "function": "Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LSW3;O55008", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O55007-4", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70597-1", "uniprot_id": [ { "id": "PX11A_RAT", "url": "https://www.uniprot.org/uniprot/O70597", "type": "external" } ], "mass": 27923.0, "length": 246, "protein_name": "Peroxisomal membrane protein 11A", "gene_name": "Pex11a", "organism": "Rat", "refseq_name": "peroxisomal membrane protein 11A", "refseq_ac": [ { "id": "NP_445939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445939", "type": "external" } ], "gene_names_uniprotkb": "Pex11a; Pex11", "gene_names_refseq": "Pex11a; Pmp26p", "protein_names_uniprotkb": "Peroxisomal membrane protein 11A; 28 kDa peroxisomal integral membrane protein; PEX11-alpha; PMP28; Peroxin-11A; Peroxisomal biogenesis factor 11A; Peroxisomal coatomer receptor; Peroxisomal membrane protein 26; Pmp26p; Protein PEX11 homolog alpha; RnPEX11p", "protein_names_refseq": "28 kDa peroxisomal integral membrane protein; PEX11-alpha; PEX11alpha; PMP28; peroxin-11A; peroxisomal biogenesis factor 11A; peroxisomal coatomer receptor; peroxisomal membrane protein 11A; peroxisomal membrane protein 26; peroxisomal membrane protein Pmp26p (Peroxin-11); pex11palpha; protein PEX11 homolog alpha; rnPEX11p", "tax_id": 10116, "disease": "", "pathway": " (rno:85249)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "9548716;9714566;9792670", "class_list": "", "function": "May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (PubMed:9548716). Promotes membrane protrusion and elongation on the peroxisomal surface., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P749", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0016559 peroxisome fission;GO:0050873 brown fat cell differentiation;GO:0007031 peroxisome organization;GO:0016557 peroxisome membrane biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70597-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20417-1", "uniprot_id": [ { "id": "PTN1_RAT", "url": "https://www.uniprot.org/uniprot/P20417", "type": "external" } ], "mass": 49674.0, "length": 432, "protein_name": "Tyrosine-protein phosphatase non-receptor type 1", "gene_name": "Ptpn1", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 1", "refseq_ac": [ { "id": "NP_036769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036769", "type": "external" } ], "gene_names_uniprotkb": "Ptpn1", "gene_names_refseq": "Ptp1b; Ptpn1; Ptp", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 1; 3.1.3.48; PTP-1B; Protein-tyrosine phosphatase 1B", "protein_names_refseq": "PTP-1B; protein-tyrosine phosphatase 1B; tyrosine-protein phosphatase non-receptor type 1", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24697); (R-RNO-354192); (R-RNO-6807004); (R-RNO-77387); (R-RNO-8849472); (R-RNO-912694); (R-RNO-982772); (R-RNO-9860927)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "1599438;2154749;23481236;33511306;38043267;38334011", "class_list": "", "function": "Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-kappaB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. Erratum:[CNS Neurosci Ther. 2025 Aug;31(8):e70557. doi: 10.1111/cns.70557. PMID: 40755269], [RefSeq, PubMed]; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity)., [UniProtKB]; Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005769 early endosome", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:2000646 positive regulation of receptor catabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20417-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41499-2", "uniprot_id": [ { "id": "PTN11_RAT", "url": "https://www.uniprot.org/uniprot/P41499", "type": "external" } ], "mass": 68033.0, "length": 593, "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "Ptpn11", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 11 isoform 1", "refseq_ac": [ { "id": "NP_001171064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171064", "type": "external" } ], "gene_names_uniprotkb": "Ptpn11", "gene_names_refseq": "Ptpn11; Shp2", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 11; 3.1.3.48; PTP-1D; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase SYP; SH-PTP2; SHP-2; Shp2", "protein_names_refseq": "PTP-1D; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SHP-2; encodes catalytic domain; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; tyrosine-protein phosphatase non-receptor type 11 isoform 1; tyrosine-protein phosphatase non-receptor type 11", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); juvenile myelomonocytic leukemia (Disease Ontology:DOID:0050458); hepatocellular adenoma (Disease Ontology:DOID:0050868); idiopathic scoliosis (Disease Ontology:DOID:0060250); Noonan syndrome 1 (Disease Ontology:DOID:0060578); Noonan syndrome with multiple lentigines 1 (Disease Ontology:DOID:0080548); metachondromatosis (Disease Ontology:DOID:0111512); stomach cancer (Disease Ontology:DOID:10534); anogenital venereal wart (Disease Ontology:DOID:11168); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); Noonan syndrome with multiple lentigines (Disease Ontology:DOID:14291); glaucoma (Disease Ontology:DOID:1686); chondroma (Disease Ontology:DOID:2602); Noonan syndrome (Disease Ontology:DOID:3490); cervical cancer (Disease Ontology:DOID:4362); tetralogy of Fallot (Disease Ontology:DOID:6419); atrophic gastritis (Disease Ontology:DOID:8929)", "pathway": " (rno:25622); (R-RNO-1059683); (R-RNO-109704); (R-RNO-110056); (R-RNO-112411); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1295596); (R-RNO-1433557); (R-RNO-180292); (R-RNO-186763); (R-RNO-210990); (R-RNO-210993); (R-RNO-389513); (R-RNO-389948); (R-RNO-432142); (R-RNO-512988); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654700); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-8854691); (R-RNO-8865999); (R-RNO-8934593); (R-RNO-912694); (R-RNO-936964); (R-RNO-9674555); (R-RNO-9927353)", "pathway_count": 38, "publication_count": 11, "publication_id_list": "1382983;16885344;22673903;29093677;29214191;35400714;35652623;7512964;8048963;8810330;9062191", "class_list": "", "function": "Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (By similarity). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity). Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to TCR signaling inhibition (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Retinal Src homology region 2-containing protein tyrosine phosphatase 2 silencing alleviates diabetic retinopathy via suppressing inflammatory response and oxidative stress by regulating Yes-associated protein 1 activity., [RefSeq, PubMed]; Shp2 in Alveolar Macrophages Regulates Macrophage I Phenotype in Acute Lung Injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62626", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0036302 atrioventricular canal development;GO:0048806 genitalia development;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0060125 negative regulation of growth hormone secretion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P41499-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53042-1", "uniprot_id": [ { "id": "PPP5_RAT", "url": "https://www.uniprot.org/uniprot/P53042", "type": "external" } ], "mass": 56917.0, "length": 499, "protein_name": "Serine/threonine-protein phosphatase 5", "gene_name": "Ppp5c", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 5", "refseq_ac": [ { "id": "NP_113917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113917", "type": "external" } ], "gene_names_uniprotkb": "Ppp5c", "gene_names_refseq": "Ppp5c", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 5; 3.1.3.16; PP5; PPT; Protein phosphatase T", "protein_names_refseq": "PP5; PPT; protein phosphatase T; serine/threonine-protein phosphatase 5", "tax_id": 10116, "disease": "", "pathway": " (rno:65179); (R-RNO-5675221); (R-RNO-5693565); (R-RNO-8939211)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "11523989;11969423;12176367;15546861;16549782;16790549;16892053;26182372;35043508;36494772;8077208", "class_list": "", "function": "Increased protein phosphatase 5 expression in inflammation-induced left ventricular dysfunction in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Relevance of c-Src and protein phosphatase 2A to aromatase activity: Evidence of an acute self-regulating oestrogenic signalling complex in rat central nervous system., [RefSeq, PubMed]; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed:11523989, PubMed:12176367, PubMed:15546861, PubMed:16549782, PubMed:16892053). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (By similarity). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (By similarity). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (By similarity). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (By similarity). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (By similarity). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed:15546861). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (PubMed:16549782). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon", "go_biological_process": "GO:1904550 response to arachidonate;GO:0010288 response to lead ion;GO:0043066 negative regulation of apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0043278 response to morphine", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53042-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97887-1", "uniprot_id": [ { "id": "PSN1_RAT", "url": "https://www.uniprot.org/uniprot/P97887", "type": "external" } ], "mass": 52790.0, "length": 468, "protein_name": "Presenilin-1", "gene_name": "Psen1", "organism": "Rat", "refseq_name": "presenilin-1", "refseq_ac": [ { "id": "NP_062036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062036", "type": "external" } ], "gene_names_uniprotkb": "Psen1; Psnl1", "gene_names_refseq": "Psen1", "protein_names_uniprotkb": "Presenilin-1; 3.4.23.-; PS-1; Protein S182", "protein_names_refseq": "PS-1; presenilin-1", "tax_id": 10116, "disease": "frontotemporal dementia 1 (Disease Ontology:DOID:0051060); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1U (Disease Ontology:DOID:0110455); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (rno:29192); (R-RNO-1251985); (R-RNO-193692); (R-RNO-205043); (R-RNO-3928665); (R-RNO-6798695); (R-RNO-9013507); (R-RNO-9017802); (R-RNO-9839383)", "pathway_count": 9, "publication_count": 8, "publication_id_list": "21454685;22673903;29392878;30429473;32265300;34897970;8710164;9047347", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (By similarity). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis. Involved in the regulation of neurite outgrowth (By similarity). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity (By similarity). It acts through the control of SYT7 presynaptic expression (PubMed:30429473)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Knock-in rats with homozygous PSEN1(L435F) Alzheimer mutation are viable and show selective gamma-secretase activity loss causing low Abeta40/42 and high Abeta43., [RefSeq, PubMed]; MiR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1., [RefSeq, PubMed]; Results revealed a common, vesicle-type indiscriminate trafficking defect in PS1DeltaE9 astrocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97529", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004175 endopeptidase activity;GO:0005262 calcium channel activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0002573 myeloid leukocyte differentiation;GO:0001708 cell fate specification;GO:0016080 synaptic vesicle targeting;GO:0000045 autophagosome assembly;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P97887-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M865-1", "uniprot_id": [ { "id": "PAGR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M865", "type": "external" } ], "mass": 27683.0, "length": 253, "protein_name": "PAXIP1-associated glutamate-rich protein 1", "gene_name": "Pagr1", "organism": "Rat", "refseq_name": "PAXIP1-associated glutamate-rich protein 1", "refseq_ac": [ { "id": "NP_001380785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380785", "type": "external" } ], "gene_names_uniprotkb": "Pagr1", "gene_names_refseq": "Pa1; Pagr1; RGD1305592", "protein_names_uniprotkb": "PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated protein 1", "protein_names_refseq": "PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated protein 1", "tax_id": 10116, "disease": "esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (rno:293500); (R-RNO-9772755); (R-RNO-9818564)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex", "go_biological_process": "GO:0060717 chorion development;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M865-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1X7-1", "uniprot_id": [ { "id": "S39A3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1X7", "type": "external" } ], "mass": 33964.0, "length": 317, "protein_name": "Zinc transporter ZIP3", "gene_name": "Slc39a3", "organism": "Rat", "refseq_name": "zinc transporter ZIP3", "refseq_ac": [ { "id": "NP_001008357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008357", "type": "external" } ], "gene_names_uniprotkb": "Slc39a3; Zip3", "gene_names_refseq": "Slc39a3", "protein_names_uniprotkb": "Zinc transporter ZIP3; Solute carrier family 39 member 3; ZIP-3; Zrt- and Irt-like protein 3", "protein_names_refseq": "ZIP-3; solute carrier family 39 (zinc transporter), member 3; zinc transporter ZIP3; zrt- and Irt-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:314637); (R-RNO-442380)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted milk within the alveolar lumen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0098686 hippocampal mossy fiber to CA3 synapse", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0001701 in utero embryonic development;GO:0000902 cell morphogenesis;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1X7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64256-1", "uniprot_id": [ { "id": "PRM3_RAT", "url": "https://www.uniprot.org/uniprot/Q64256", "type": "external" } ], "mass": 11450.0, "length": 104, "protein_name": "Protamine-3", "gene_name": "Prm3", "organism": "Rat", "refseq_name": "protamine-3", "refseq_ac": [ { "id": "NP_001002855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002855", "type": "external" } ], "gene_names_uniprotkb": "Prm3", "gene_names_refseq": "Prm3", "protein_names_uniprotkb": "Protamine-3; Sperm protamine P3", "protein_names_refseq": "protamine-3; sperm protamine P3", "tax_id": 10116, "disease": "", "pathway": " (rno:442921)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;8521723;8720108", "class_list": "", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030317 flagellated sperm motility;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64256-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXS5-1", "uniprot_id": [ { "id": "SERB1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXS5", "type": "external" } ], "mass": 44754.0, "length": 407, "protein_name": "SERPINE1 mRNA-binding protein 1", "gene_name": "Serbp1", "organism": "Rat", "refseq_name": "SERPINE1 mRNA-binding protein 1", "refseq_ac": [ { "id": "NP_659554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659554", "type": "external" } ], "gene_names_uniprotkb": "Serbp1; Pairbp1; Rda288", "gene_names_refseq": "Pai-Rbp1; Pairbp1; Rda288; Serbp1", "protein_names_uniprotkb": "SERPINE1 mRNA-binding protein 1; PAI-RBP1; PAI1 RNA-binding protein 1; Plasminogen activator inhibitor 1 RNA-binding protein; RDA288", "protein_names_refseq": "PAI-1 mRNA-binding protein; PAI1 RNA-binding protein 1; RNA binding protein RDA288; SERPINE1 mRNA-binding protein 1; hypothetical RNA binding protein RDA288; plasminogen activator inhibitor 1 RNA-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:246303)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11001948;12112363;14988380;15814896;21454685;22673903;23242527", "class_list": "", "function": "PAIRBP1 plays an important role in mediating the antiapoptotic action of progesterone in ovarian granulosa and luteal cells., [RefSeq, PubMed]; RDA288 in cytoplasm and plasma membrane components of granulosa cells of antral follicles. Present on extracellular surface of plasma membrane. RDA288 plays significant role in mediating progesterone's antiapoptotic action in granulosa cells., [RefSeq, PubMed]; Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These studies support the concept that the interaction between PAIRBP1-PGRMC1 is an essential component of the mechanism through which progesterone inhibits apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHU3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0030371 translation repressor activity;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding;GO:0061770 translation elongation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030578 PML body organization;GO:0017148 negative regulation of translation;GO:0042981 regulation of apoptotic process;GO:0141014 ribosome hibernation;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6AXS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYC5-1", "uniprot_id": [ { "id": "RHG15_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYC5", "type": "external" } ], "mass": 55014.0, "length": 482, "protein_name": "Rho GTPase-activating protein 15", "gene_name": "Arhgap15", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 15 isoform 1", "refseq_ac": [ { "id": "NP_001013939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013939", "type": "external" } ], "gene_names_uniprotkb": "Arhgap15", "gene_names_refseq": "Arhgap15", "protein_names_uniprotkb": "Rho GTPase-activating protein 15; ArhGAP15; Rho-type GTPase-activating protein 15", "protein_names_refseq": "rho GTPase-activating protein 15 isoform 1; rho GTPase-activating protein 15-like; rho GTPase-activating protein 15; rho-type GTPase-activating protein 15", "tax_id": 10116, "disease": "", "pathway": " (rno:295635); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XKD3-1", "uniprot_id": [ { "id": "PD2R2_RAT", "url": "https://www.uniprot.org/uniprot/Q6XKD3", "type": "external" } ], "mass": 45316.0, "length": 403, "protein_name": "Prostaglandin D2 receptor 2", "gene_name": "Ptgdr2", "organism": "Rat", "refseq_name": "prostaglandin D2 receptor 2", "refseq_ac": [ { "id": "NP_001012070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012070", "type": "external" } ], "gene_names_uniprotkb": "Ptgdr2; Crth2; Gpr44", "gene_names_refseq": "Crth2; Gpr44; Ptgdr2", "protein_names_uniprotkb": "Prostaglandin D2 receptor 2; G protein-coupled receptor 44", "protein_names_refseq": "G protein-coupled receptor 44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor 2", "tax_id": 10116, "disease": "aspergillosis (Disease Ontology:DOID:13564); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rhinitis (Disease Ontology:DOID:4483); allergic asthma (Disease Ontology:DOID:9415); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (rno:309212); (R-RNO-391908); (R-RNO-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004958 prostaglandin F receptor activity;GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0006935 chemotaxis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6XKD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP54-1", "uniprot_id": [ { "id": "RIPR2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP54", "type": "external" } ], "mass": 144709.0, "length": 1310, "protein_name": "Rho family-interacting cell polarization regulator 2", "gene_name": "Ripor2", "organism": "Rat", "refseq_name": "rho family-interacting cell polarization regulator 2", "refseq_ac": [ { "id": "NP_001014031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014031", "type": "external" } ], "gene_names_uniprotkb": "Ripor2; Fam65b", "gene_names_refseq": "Ab2-162; Fam65b; RGD1306939; Ripor2", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 2", "protein_names_refseq": "family with sequence similarity 65, member B; protein FAM65B; rho family-interacting cell polarization regulator 2", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 104 (Disease Ontology:DOID:0110465); autosomal dominant nonsyndromic deafness 21 (Disease Ontology:DOID:0110551)", "pathway": " (rno:306934)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;24958875;29393594", "class_list": "", "function": "Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (By similarity). Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear. Plays a role for maintaining the structural organization of the basal domain of stereocilia. Involved in mechanosensory hair cell function. Required for normal hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0071889 14-3-3 protein binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0030175 filopodium", "go_biological_process": "GO:1990869 cellular response to chemokine;GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0051260 protein homooligomerization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TP54-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZR7-1", "uniprot_id": [ { "id": "S35A4_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZR7", "type": "external" } ], "mass": 34705.0, "length": 324, "protein_name": "Probable UDP-sugar transporter protein SLC35A4", "gene_name": "Slc35a4", "organism": "Rat", "refseq_name": "probable UDP-sugar transporter protein SLC35A4", "refseq_ac": [ { "id": "NP_671481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671481", "type": "external" } ], "gene_names_uniprotkb": "Slc35a4; Clrp", "gene_names_refseq": "Plrr-4; Plrr4; Slc35a4", "protein_names_uniprotkb": "Probable UDP-sugar transporter protein SLC35A4; Complex leucine repeat protein; Solute carrier family 35 member A4", "protein_names_refseq": "PLRR-4 polymorphic leucine-rich repeat protein; complex leucine repeat protein; probable UDP-sugar transporter protein SLC35A4", "tax_id": 10116, "disease": "", "pathway": " (rno:257647); (R-RNO-9939291)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12124754", "class_list": "", "function": "Complex leucine repeat protein (Clrp, Plrr4) of the Golgi apparatus expressed by specific neurons of the rat brain., [RefSeq, PubMed]; Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKL6", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005743 mitochondrial inner membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0055085 transmembrane transport;GO:1901857 positive regulation of cellular respiration;GO:0032056 positive regulation of translation in response to stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91ZR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHZ9-1", "uniprot_id": [ { "id": "S38A3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHZ9", "type": "external" } ], "mass": 55637.0, "length": 504, "protein_name": "Sodium-coupled neutral amino acid transporter 3", "gene_name": "Slc38a3", "organism": "Rat", "refseq_name": "sodium-coupled neutral amino acid transporter 3", "refseq_ac": [ { "id": "NP_665719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665719", "type": "external" } ], "gene_names_uniprotkb": "Slc38a3; Snat3", "gene_names_refseq": "Nat1; Slc38a3; Sn1; Snat3", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 3; N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; Solute carrier family 38 member 3; System N amino acid transporter 1", "protein_names_refseq": "N-system amino acid transporter 1; Na(+)-coupled neutral amino acid transporter 3; sodium-coupled neutral amino acid transporter 3; system N amino acid transporter 1; system N1 amino acid transporter", "tax_id": 10116, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); developmental and epileptic encephalopathy 102 (Disease Ontology:DOID:0070388)", "pathway": " (rno:252919); (R-RNO-352230)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10619430;10823827;11742981;11850497;15716335;16249471;17148440;17909850;19596860;20739622;21454685;21525297;28272791;29561757", "class_list": "", "function": "Data report that the transport activity of the glutamine transporter SNAT3 is rapidly reduced on PKC activation by phorbol esters via a specific trafficking mechanism in oocytes., [RefSeq, PubMed]; Results demonstrate that SNAT3 is functionally active in perisynaptic astrocytes in situ. As a result, astrocytic Nai+ signaling, as would be stimulated by neighboring synaptic activity, has the capacity to stimulate astrocytic glutamine release to support glutamate recycling, [RefSeq, PubMed]; Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10619430, PubMed:10823827, PubMed:11742981, PubMed:11850497, PubMed:16249471, PubMed:17148440, PubMed:19596860, PubMed:21525297, PubMed:28272791, PubMed:29561757). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons (PubMed:10619430, PubMed:28272791, PubMed:29561757). Also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10619430, PubMed:10823827, PubMed:11742981, PubMed:11850497, PubMed:16249471, PubMed:17148440, PubMed:19596860, PubMed:21525297, PubMed:28272791, PubMed:29561757). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+), pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10619430, PubMed:10823827, PubMed:11742981, PubMed:11850497, PubMed:16249471, PubMed:17148440, PubMed:17909850, PubMed:19596860, PubMed:28272791). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (PubMed:11742981). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 transporters in astrocytes in situ. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q66HS0", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0005295 neutral L-amino acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:1903713 asparagine transmembrane transport;GO:0051365 cellular response to potassium ion starvation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007565 female pregnancy;GO:0006868 glutamine transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9JHZ9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV78-1", "uniprot_id": [ { "id": "PLVAP_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV78", "type": "external" } ], "mass": 50033.0, "length": 438, "protein_name": "Plasmalemma vesicle-associated protein", "gene_name": "Plvap", "organism": "Rat", "refseq_name": "plasmalemma vesicle-associated protein", "refseq_ac": [ { "id": "NP_064471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064471", "type": "external" } ], "gene_names_uniprotkb": "Plvap; Pv1", "gene_names_refseq": "Plvap; Pv1", "protein_names_uniprotkb": "Plasmalemma vesicle-associated protein; PV-1; Plasmalemma vesicle protein 1; gp68", "protein_names_refseq": "PV-1; gp68; plasmalemma vesicle protein 1; plasmalemma vesicle-associated protein", "tax_id": 10116, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (rno:56765)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10366592;10557298;12475376;14630628;15640522;19837874", "class_list": "", "function": "Data show that PV-1 was detected exclusively over highly permeable regions of the brain by in situ hybridization., [RefSeq, PubMed]; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development., [UniProtKB, UniProtKB]; PV-1 is developmentally regulated in the rat lung and shows a divergent intracellular localization, with a limited caveolae/Cav-1 colocalization in cultured endothelial cells., [RefSeq, PubMed]; Tested the role of PV1 in the structure of the diaphragms and demonstrated that multiple PV1 homodimers reside in close proximity within the same diaphragm., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0005901 caveola", "go_biological_process": "GO:0000165 MAPK cascade;GO:0032502 developmental process;GO:0043114 regulation of vascular permeability;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0002693 positive regulation of cellular extravasation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WV78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35254-1", "uniprot_id": [ { "id": "GORS1_RAT", "url": "https://www.uniprot.org/uniprot/O35254", "type": "external" } ], "mass": 47673.0, "length": 451, "protein_name": "Golgi reassembly-stacking protein 1", "gene_name": "Gorasp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gorasp1; Grasp65", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi reassembly-stacking protein 1; GRASP65; Golgi peripheral membrane protein p65; Golgi reassembly-stacking protein of 65 kDa", "protein_names_refseq": "", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:56082); (R-RNO-162658); (R-RNO-204005); (R-RNO-6807878)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11050165;11706049;11739401;11739402;11815631;12015985;12839990;22673903;23940043;9346242", "class_list": "", "function": "Key structural protein of the Golgi apparatus (By similarity). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (By similarity). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (By similarity). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:12839990, PubMed:23940043, PubMed:9346242). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (PubMed:11815631, PubMed:12015985). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0050774 negative regulation of dendrite morphogenesis;GO:0006487 protein N-linked glycosylation;GO:0090161 Golgi ribbon formation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O35254-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28818-1", "uniprot_id": [ { "id": "RGRF1_RAT", "url": "https://www.uniprot.org/uniprot/P28818", "type": "external" } ], "mass": 142667.0, "length": 1244, "protein_name": "Ras-specific guanine nucleotide-releasing factor 1", "gene_name": "Rasgrf1", "organism": "Rat", "refseq_name": "ras-specific guanine nucleotide-releasing factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001164002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164002", "type": "external" } ], "gene_names_uniprotkb": "Rasgrf1", "gene_names_refseq": "GNRP; P140 RAS-GRF; Rasgrf1", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor 1; GNRP; Guanine nucleotide-releasing protein; P140 Ras-GRF; Ras-GRF1", "protein_names_refseq": "guanine nucleotide-releasing protein; ras-specific guanine nucleotide-releasing factor 1 isoform 1; ras-specific guanine nucleotide-releasing factor 1", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:192213); (R-RNO-5673001)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10373510;12538592;1379346;21382555;25644714;26890742;31245854", "class_list": "", "function": "Novel mercaptoacetamide-based class II histone deacetylase inhibitor HDACIW2 treatment regulated the levels of RasGRF1 and p-ERK, and that W2 requires RasGRF1 and ERK signaling to alter dendritic spine formation, suggesting that W2 regulates dendritic spine formation via a RasGRF1/ERK-dependent signaling pathway, [RefSeq, PubMed]; Our data indicate that superoxide production is induced by the NR2B-NMDARs/RasGRF1/NOX2 pathway and promotes dendritogenesis., [RefSeq, PubMed]; Promotes the exchange of Ras-bound GDP by GTP., [UniProtKB, PubMed]; VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0030971 receptor tyrosine kinase binding;GO:0035254 glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030426 growth cone", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0008283 cell population proliferation;GO:0031175 neuron projection development;GO:0032869 cellular response to insulin stimulus;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28818-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUQ0-1", "uniprot_id": [ { "id": "RIPL1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUQ0", "type": "external" } ], "mass": 47330.0, "length": 406, "protein_name": "RILP-like protein 1", "gene_name": "Rilpl1", "organism": "Rat", "refseq_name": "RILP-like protein 1", "refseq_ac": [ { "id": "NP_001178594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178594", "type": "external" } ], "gene_names_uniprotkb": "Rilpl1", "gene_names_refseq": "GOSPEL; RGD1307973; Rilpl1", "protein_names_uniprotkb": "RILP-like protein 1; GAPDH's competitor of SIAH1 protein enhances life; GOSPEL; Rab-interacting lysosomal-like protein 1", "protein_names_refseq": "GAPDH's competitor of SIAH1 protein enhances life; RILP-like protein 1; rab-interacting lysosomal-like protein 1", "tax_id": 10116, "disease": "oculopharyngodistal myopathy 4 (Disease Ontology:DOID:0081300)", "pathway": " (rno:304469)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19607794;22673903", "class_list": "", "function": "Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (PubMed:19607794). Competes with SIAH1 for binding GAPDH (PubMed:19607794). Does not regulate lysosomal morphology and distribution (By similarity). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0031267 small GTPase binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "GO:0007263 nitric oxide mediated signal transduction;GO:0060271 cilium assembly;GO:0003382 epithelial cell morphogenesis;GO:1903445 protein transport from ciliary membrane to plasma membrane;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUQ0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08774-1", "uniprot_id": [ { "id": "RGS12_RAT", "url": "https://www.uniprot.org/uniprot/O08774", "type": "external" } ], "mass": 150469.0, "length": 1387, "protein_name": "Regulator of G protein signaling 12", "gene_name": "Rgs12", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 12", "refseq_ac": [ { "id": "NP_062212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062212", "type": "external" } ], "gene_names_uniprotkb": "Rgs12", "gene_names_refseq": "Rgs12", "protein_names_uniprotkb": "Regulator of G protein signaling 12; RGS12", "protein_names_refseq": "regulator of G-protein signaling 12; regulator of G-protein signalling 12", "tax_id": 10116, "disease": "", "pathway": " (rno:54292); (R-RNO-418594)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11387333;16819986;17380122;22673903;34674723;9168931;9651375", "class_list": "", "function": "MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88383", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0038032 termination of G protein-coupled receptor signaling pathway;GO:0007165 signal transduction;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0008277 regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08774-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1U9-1", "uniprot_id": [ { "id": "RFNG_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1U9", "type": "external" } ], "mass": 36993.0, "length": 334, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe", "gene_name": "Rfng", "organism": "Rat", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase radical fringe", "refseq_ac": [ { "id": "NP_068621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068621", "type": "external" } ], "gene_names_uniprotkb": "Rfng", "gene_names_refseq": "Rfng", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase radical fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase radical fringe", "tax_id": 10116, "disease": "", "pathway": " (rno:60433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11165380", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (By similarity). Inhibits Notch signaling in postmitotic neurons of the brain. It may play a role in adult brain and in neurogenesis (PubMed:11165380). It may play a role in limb development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045747 positive regulation of Notch signaling pathway;GO:0007389 pattern specification process;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 19, "hit_score": 0.2, "record_id": "Q9R1U9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4S3-1", "uniprot_id": [ { "id": "S45A1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4S3", "type": "external" } ], "mass": 81752.0, "length": 751, "protein_name": "Proton-associated sugar transporter A", "gene_name": "Slc45a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc45a1; Dnb5", "gene_names_refseq": "", "protein_names_uniprotkb": "Proton-associated sugar transporter A; PAST-A; Solute carrier family 45 member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:246258)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12417639", "class_list": "", "function": "Neuron-specific proton-associated hexose transporter (PubMed:12417639). Mediates hexose efflux from lysosomes (By similarity). Hexose efflux is required for the stability of the vacuolar ATPase (V-ATPase) complex on the lysosomal membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]; Proton-associated glucose transporter in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008506 sucrose:proton symporter activity;GO:0005356 D-glucose:proton symporter activity;GO:0015517 galactose:proton symporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:1904659 D-glucose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35832-1", "uniprot_id": [ { "id": "CDK18_RAT", "url": "https://www.uniprot.org/uniprot/O35832", "type": "external" } ], "mass": 51882.0, "length": 451, "protein_name": "Cyclin-dependent kinase 18", "gene_name": "Cdk18", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 18", "refseq_ac": [ { "id": "NP_001093976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093976", "type": "external" } ], "gene_names_uniprotkb": "Cdk18; Pctaire3; Pctk3", "gene_names_refseq": "Cdk18; PCTAIRE3; Pctk3", "protein_names_uniprotkb": "Cyclin-dependent kinase 18; 2.7.11.22; Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3", "protein_names_refseq": "PCTAIRE protein kinase 3; PCTAIRE-motif protein kinase 3; cell division protein kinase 18; cyclin-dependent kinase 18; serine/threonine-protein kinase PCTAIRE-3", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 7 with cerebellar hypoplasia (Disease Ontology:DOID:0112231)", "pathway": " (rno:289019)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;22673903;29393594;9370357", "class_list": "", "function": "May play a role in signal transduction cascades in terminally differentiated cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1901987 regulation of cell cycle phase transition;GO:0031643 positive regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35832-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYR0-1", "uniprot_id": [ { "id": "RN168_RAT", "url": "https://www.uniprot.org/uniprot/B2RYR0", "type": "external" } ], "mass": 64404.0, "length": 564, "protein_name": "E3 ubiquitin-protein ligase RNF168", "gene_name": "Rnf168", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase RNF168", "refseq_ac": [ { "id": "NP_001121069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121069", "type": "external" } ], "gene_names_uniprotkb": "Rnf168; RNF168", "gene_names_refseq": "Rnf168", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF168; RING-type E3 ubiquitin transferase RNF168; ring finger protein 168, E3 ubiquitin protein ligase", "tax_id": 10116, "disease": "RIDDLE syndrome (Disease Ontology:DOID:0090113)", "pathway": " (rno:690043); (R-RNO-3108214); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0035861 site of double-strand break;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0032880 regulation of protein localization;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B2RYR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU57-1", "uniprot_id": [ { "id": "RIOX1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU57", "type": "external" } ], "mass": 67455.0, "length": 597, "protein_name": "Ribosomal oxygenase 1", "gene_name": "Riox1", "organism": "Rat", "refseq_name": "ribosomal oxygenase 1", "refseq_ac": [ { "id": "NP_001101510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101510", "type": "external" } ], "gene_names_uniprotkb": "Riox1; Mapjd; No66", "gene_names_refseq": "No66; RGD1307704; Riox1", "protein_names_uniprotkb": "Ribosomal oxygenase 1; 1.14.11.27; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Histone lysine demethylase NO66", "protein_names_refseq": "bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; myc-associated protein with JmjC domain; nucleolar protein 66; ribosomal oxygenase 1", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:314300); (R-RNO-9629569)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. Also catalyzes demethylation of non-histone proteins, such as CGAS: demethylation of monomethylated CGAS promotes interaction between CGAS and PARP1, followed by PARP1 inactivation (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis. Participates in MYC-induced transcriptional activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0005506 iron ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045668 negative regulation of osteoblast differentiation;GO:0006282 regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZU57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXK7-1", "uniprot_id": [ { "id": "RN123_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXK7", "type": "external" } ], "mass": 149077.0, "length": 1318, "protein_name": "E3 ubiquitin-protein ligase RNF123", "gene_name": "Rnf123", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf123; Kpc1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF123; 2.3.2.27; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-5689880); (R-RNO-983168)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19015242;22673903", "class_list": "", "function": "Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B: acts by catalyzing ubiquitination of the NFKB1 p105 precursor, leading to limited proteasomal degradation of NFKB1 p105 and generation of the active NFKB1 p50 subunit. Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051604 protein maturation;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZXK7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TLK4-1", "uniprot_id": [ { "id": "RHG27_RAT", "url": "https://www.uniprot.org/uniprot/Q6TLK4", "type": "external" } ], "mass": 97180.0, "length": 869, "protein_name": "Rho GTPase-activating protein 27", "gene_name": "Arhgap27", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 27", "refseq_ac": [ { "id": "NP_942054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942054", "type": "external" } ], "gene_names_uniprotkb": "Arhgap27; Camgap1", "gene_names_refseq": "Arhgap15; Arhgap27; CAMGAP1", "protein_names_uniprotkb": "Rho GTPase-activating protein 27; CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; Rho-type GTPase-activating protein 27", "protein_names_refseq": "CIN85-associated multi-domain containing RhoGAP 1; CIN85-associated multi-domain-containing Rho GTPase-activating protein 1; Rho GTPase activating protein 15; rho GTPase-activating protein 27; rho-type GTPase-activating protein 27", "tax_id": 10116, "disease": "", "pathway": " (rno:303583); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15147912;22673903", "class_list": "", "function": "Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0006898 receptor-mediated endocytosis;GO:0006897 endocytosis;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6TLK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36860-1", "uniprot_id": [ { "id": "RALB_RAT", "url": "https://www.uniprot.org/uniprot/P36860", "type": "external" } ], "mass": 23317.0, "length": 206, "protein_name": "Ras-related protein Ral-B", "gene_name": "Ralb", "organism": "Rat", "refseq_name": "ras-related protein Ral-B", "refseq_ac": [ { "id": "NP_446273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446273", "type": "external" } ], "gene_names_uniprotkb": "Ralb; Ral-b", "gene_names_refseq": "Ralb; dRalb", "protein_names_uniprotkb": "Ras-related protein Ral-B; 3.6.5.2", "protein_names_refseq": "GTP binding protein); RALB Ras like proto-oncogene B; ras-related protein Ral-B; v-ral simian leukemia viral oncogene homolog B (ras related); v-ral simian leukemia viral oncogene homolog B (ras related", "tax_id": 10116, "disease": "pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (rno:116546)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16330713;16382162;17202486;22393054;7687439", "class_list": "", "function": "Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (PubMed:17202486). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (PubMed:16382162). Required for suppression of apoptosis (By similarity). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (By similarity). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Our results indicate that endogenous RalA and RalB function specifically as GTP sensors for the GTP-dependent exocytosis of dense core vesicles., [RefSeq, PubMed]; Phosphorylation by PKCalpha is critical for RalB-mediated vesicle trafficking and exocytosis., [RefSeq, PubMed]; RalB regulation of exocyst function is required for the coordinated delivery of secretory vesicles to the sites of dynamic plasma membrane expansion that specify directional movement., [RefSeq, PubMed]; The two Ral isoforms, RalA and -B, promote branching through distinct pathways, involving the exocyst complex and phospholipase D, respectively., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0031623 receptor internalization;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0007265 Ras protein signal transduction;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36860-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M386-1", "uniprot_id": [ { "id": "RPGF2_RAT", "url": "https://www.uniprot.org/uniprot/F1M386", "type": "external" } ], "mass": 166388.0, "length": 1496, "protein_name": "Rap guanine nucleotide exchange factor 2", "gene_name": "Rapgef2", "organism": "Rat", "refseq_name": "rap guanine nucleotide exchange factor 2 isoform X8", "refseq_ac": [ { "id": "XP_063137884", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063137884", "type": "external" } ], "gene_names_uniprotkb": "Rapgef2; Pdzgef1", "gene_names_refseq": "PDZ-GEF1; RA-GEF-1; Rapgef2; nRap GEP", "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; CNrasGEF; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1; nRap GEP", "protein_names_refseq": "rap guanine nucleotide exchange factor 2 isoform X8", "tax_id": 10116, "disease": "familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694)", "pathway": " (rno:310533); (R-RNO-5673001)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10548487;10801446;10873669;12391161;15340146;17496889;17724123;18683930;19322778;21382555;22673903", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3ZD17", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019901 protein kinase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0050699 WW domain binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "F1M386-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35550-1", "uniprot_id": [ { "id": "RABE1_RAT", "url": "https://www.uniprot.org/uniprot/O35550", "type": "external" } ], "mass": 99428.0, "length": 862, "protein_name": "Rab GTPase-binding effector protein 1", "gene_name": "Rabep1", "organism": "Rat", "refseq_name": "rab GTPase-binding effector protein 1", "refseq_ac": [ { "id": "NP_061997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061997", "type": "external" } ], "gene_names_uniprotkb": "Rabep1; Rabpt5a; Rabpt5", "gene_names_refseq": "Rabep1", "protein_names_uniprotkb": "Rab GTPase-binding effector protein 1; Rabaptin-5alpha; Rabaptin-5", "protein_names_refseq": "rab GTPase-binding effector protein 1; rabaptin-5alpha; rabaptin-5", "tax_id": 10116, "disease": "", "pathway": " (rno:54190)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;22841712", "class_list": "", "function": "Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70609", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0016192 vesicle-mediated transport;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35550-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CFD1-1", "uniprot_id": [ { "id": "RBM45_RAT", "url": "https://www.uniprot.org/uniprot/Q8CFD1", "type": "external" } ], "mass": 53431.0, "length": 476, "protein_name": "RNA-binding protein 45", "gene_name": "Rbm45", "organism": "Rat", "refseq_name": "RNA-binding protein 45", "refseq_ac": [ { "id": "NP_695218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695218", "type": "external" } ], "gene_names_uniprotkb": "Rbm45; Drb1; Drbp1", "gene_names_refseq": "Drb1; Rbm45", "protein_names_uniprotkb": "RNA-binding protein 45; Developmentally-regulated RNA-binding protein 1; RNA-binding motif protein 45", "protein_names_refseq": "RNA-binding protein 45; developmentally-regulated RNA-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:266631)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12220514;22673903", "class_list": "", "function": "A new member of RRM-type neural RNA-binding protein, [RefSeq, PubMed]; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CFD1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R5D6-1", "uniprot_id": [ { "id": "RN157_RAT", "url": "https://www.uniprot.org/uniprot/M0R5D6", "type": "external" } ], "mass": 74565.0, "length": 682, "protein_name": "E3 ubiquitin ligase Rnf157", "gene_name": "Rnf157", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rnf157; LOC688272", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin ligase Rnf157; 2.3.2.27; RING finger protein 157; RING-type E3 ubiquitin transferase Rnf157", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "25342469;38843836", "class_list": "", "function": "E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (By similarity). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (By similarity). May act as a scaffold molecule to regulate this process (By similarity). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity)., [UniProtKB, UniProtKB]; E3 ubiquitin ligase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0044297 cell body", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0043066 negative regulation of apoptotic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "M0R5D6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08773-1", "uniprot_id": [ { "id": "RGS14_RAT", "url": "https://www.uniprot.org/uniprot/O08773", "type": "external" } ], "mass": 59492.0, "length": 544, "protein_name": "Regulator of G protein signaling 14", "gene_name": "Rgs14", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 14", "refseq_ac": [ { "id": "NP_446216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446216", "type": "external" } ], "gene_names_uniprotkb": "Rgs14", "gene_names_refseq": "Rgs14", "protein_names_uniprotkb": "Regulator of G protein signaling 14; RGS14", "protein_names_refseq": "regulator of G-protein signaling 14", "tax_id": 10116, "disease": "nephrolithiasis (Disease Ontology:DOID:585)", "pathway": " (rno:114705); (R-RNO-418594)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "11387333;11976690;12534294;15337739;16819986;16870394;17603074;19319189;19574389;19878719;21158412;21255223;22673903;23250758;28934222;30093406;9168931", "class_list": "", "function": "Findings describe a novel mechanism of negative regulation of RGS14 functions, specifically interactions with active Galphai and nuclear import, while leaving the function of other RGS14 domains intact Erratum:[J Biol Chem. 2019 Aug 9;294(32):12262. doi: 10.1074/jbc.AAC119.101131. PMID: 31399537], [RefSeq, PubMed]; Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors., [RefSeq, PubMed]; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) (PubMed:11976690). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Results show that endogenous RGS14 localizes to subcellular compartments not previously recognized in studies of recombinant RGS14 in unnatural host cells. The two most surprising observations were that RGS14 is not enriched at the plasma membrane, and that it is found within chromatin-rich regions of the nucleus in close proximity with active RNA Pol-II. Publication Status: Online-Only, [RefSeq, PubMed]; Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits, [RefSeq, PubMed]; Substituting protein kinase A phosphorylation site Thr494 with either aspartate or glutamate to mimic phosphorylation enhances RGS14 inhibition of nucleotide exchange activity on G alpha(i) subunits almost 3-fold., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0001965 G-protein alpha-subunit binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006913 nucleocytoplasmic transport;GO:0006979 response to oxidative stress;GO:0007059 chromosome segregation;GO:0007612 learning", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "O08773-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35789-1", "uniprot_id": [ { "id": "B3GA1_RAT", "url": "https://www.uniprot.org/uniprot/O35789", "type": "external" } ], "mass": 38237.0, "length": 334, "protein_name": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1", "gene_name": "B3gat1", "organism": "Rat", "refseq_name": "galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1", "refseq_ac": [ { "id": "NP_446455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446455", "type": "external" } ], "gene_names_uniprotkb": "B3gat1", "gene_names_refseq": "B3gat1; Hnk-1", "protein_names_uniprotkb": "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; 2.4.1.135; Beta-1,3-glucuronyltransferase 1; GlcAT-P; GlcUAT-P; Glucuronosyltransferase P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase", "protein_names_refseq": "UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; glcAT-P; glcUAT-P; glucuronosyltransferase P", "tax_id": 10116, "disease": "pulmonary fibrosis (Disease Ontology:DOID:3770)", "pathway": " (rno:117108)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15232286;16641100;19181664;19961337;21056957;26253417;9177175;9804790", "class_list": "glycogene;glycosyltransferase", "function": "Increased expression of CS-GAGs and GlcAT-I in fibrotic lungs and fibrotic lung fibroblasts, [RefSeq, PubMed]; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group., [UniProtKB, PubMed, PubMed]; Positive expression for Osterix and HNK1 in undifferentiated ectomesenchymal cells in early and late stages, [RefSeq, PubMed]; Results of these studies demonstrate that BMP-2 and TGF-beta regulate GlcAT-1 expression in nucleus pulposus cells through a signaling network comprising MAPK, AP1, Sp1, and TonEBP, [RefSeq, PubMed]; These results combined suggest that both PSA and HNK-1 carbohydrate epitopes are synthesized and may have an important role in the adult peripheral vestibular endorgans., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UHF1", "ec_number_list": [ { "id": "2.4.1.135", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.135", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0071456 cellular response to hypoxia;GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 21, "hit_score": 0.9, "record_id": "O35789-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70521-1", "uniprot_id": [ { "id": "RGS19_RAT", "url": "https://www.uniprot.org/uniprot/O70521", "type": "external" } ], "mass": 24738.0, "length": 216, "protein_name": "Regulator of G protein signaling 19", "gene_name": "Rgs19", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 19", "refseq_ac": [ { "id": "NP_067693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067693", "type": "external" } ], "gene_names_uniprotkb": "Rgs19; Gaip", "gene_names_refseq": "Camki; Gaip; Rgs19", "protein_names_uniprotkb": "Regulator of G protein signaling 19; G-alpha-interacting protein; GAIP; RGS19", "protein_names_refseq": "G alpha interacting protein; calcium/calmodulin-dependent protein kinase I; regulator of G-protein signaling 19; regulator of G-protein signalling 19", "tax_id": 10116, "disease": "", "pathway": " (rno:59293); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10760275;9571244", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, predominantly to G(i)-alpha-3. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0042802 identical protein binding;GO:0017022 myosin binding;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005903 brush border", "go_biological_process": "GO:0045471 response to ethanol;GO:0006605 protein targeting;GO:0007268 chemical synaptic transmission;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70521-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04916-1", "uniprot_id": [ { "id": "RET4_RAT", "url": "https://www.uniprot.org/uniprot/P04916", "type": "external" } ], "mass": 23220.0, "length": 201, "protein_name": "Retinol-binding protein 4", "gene_name": "Rbp4", "organism": "Rat", "refseq_name": "retinol-binding protein 4 precursor", "refseq_ac": [ { "id": "NP_037294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037294", "type": "external" } ], "gene_names_uniprotkb": "Rbp4", "gene_names_refseq": "RBPA; Rbp4", "protein_names_uniprotkb": "Retinol-binding protein 4; PRBP; Plasma retinol-binding protein; RBP", "protein_names_refseq": "PRBP; RBP; plasma retinol-binding protein; retinol binding protein 4, plasma; retinol-binding protein 4 precursor", "tax_id": 10116, "disease": "colon adenoma (Disease Ontology:DOID:0050912); stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); factor VIII deficiency (Disease Ontology:DOID:12134); dilated cardiomyopathy (Disease Ontology:DOID:12930); severe pre-eclampsia (Disease Ontology:DOID:13129); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); familial hypercholesterolemia (Disease Ontology:DOID:13810); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); gallbladder cancer (Disease Ontology:DOID:3121); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); acute pyelonephritis (Disease Ontology:DOID:559); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); hemarthrosis (Disease Ontology:DOID:801); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); hyperhomocysteinemia (Disease Ontology:DOID:9279); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25703); (R-RNO-2453902); (R-RNO-975634)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "34177800;37003483;38069063;3838985;4044565;4708098", "class_list": "", "function": "Increased RBP4 and Asprosin Are Novel Contributors in Inflammation Process of Periodontitis in Obese Rats. Publication Status: Online-Only, [RefSeq, PubMed]; RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced Rats and Patients With Hyperuricemia. Publication Status: Online-Only, [RefSeq, PubMed]; Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway., [RefSeq, PubMed]; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (PubMed:4708098). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019841 retinol binding;GO:0044877 protein-containing complex binding;GO:0016918 retinal binding;GO:0034632 retinol transmembrane transporter activity;GO:0140104 molecular carrier activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0001523 retinoid metabolic process;GO:0007283 spermatogenesis;GO:0007507 heart development;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04916-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29066-1", "uniprot_id": [ { "id": "ARRB1_RAT", "url": "https://www.uniprot.org/uniprot/P29066", "type": "external" } ], "mass": 47020.0, "length": 418, "protein_name": "Beta-arrestin-1", "gene_name": "Arrb1", "organism": "Rat", "refseq_name": "beta-arrestin-1", "refseq_ac": [ { "id": "NP_037042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037042", "type": "external" } ], "gene_names_uniprotkb": "Arrb1", "gene_names_refseq": "Arrb1; BARRES", "protein_names_uniprotkb": "Beta-arrestin-1; Arrestin beta-1", "protein_names_refseq": "beta-arrestin-1", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); major depressive disorder (Disease Ontology:DOID:1470); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:25387); (R-RNO-418555); (R-RNO-432720); (R-RNO-432722); (R-RNO-456926); (R-RNO-5674135); (R-RNO-5689880); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-9839389)", "pathway_count": 10, "publication_count": 36, "publication_id_list": "10097102;10212203;10347185;10725339;10747877;10753943;10770944;10973280;10995467;11579203;11742073;11777902;11777907;11901145;12399592;12519791;12821670;1517224;15173580;15520010;15878855;16641100;17594911;18006496;22673903;22810587;23886940;31948726;37209686;38152023;38175886;38838859;8553074;9388255;9822622;9924018", "class_list": "", "function": "ARRB1 inhibits extracellular matrix degradation and apoptosis of nucleus pulposus cells by promoting autophagy and attenuates intervertebral disc degeneration., [RefSeq, PubMed]; Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins., [RefSeq, PubMed]; Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Involved in smoothened (SMO) localization to primary cilium (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (By similarity). Involved in some MRGPRE-mediated signaling required to improve glucose tolerance: promotes phosphorylation of ALDOA downstream of MRGPRE activation, increasing glycolysis and leading to GLP-1 secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; MiR-22-3p in the rostral ventrolateral medulla promotes hypertension through inhibiting beta-arrestin-1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003713 transcription coactivator activity;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome", "go_biological_process": "GO:0050975 sensory perception of touch;GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P29066-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31044-1", "uniprot_id": [ { "id": "PEBP1_RAT", "url": "https://www.uniprot.org/uniprot/P31044", "type": "external" } ], "mass": 20801.0, "length": 187, "protein_name": "Phosphatidylethanolamine-binding protein 1", "gene_name": "Pebp1", "organism": "Rat", "refseq_name": "phosphatidylethanolamine-binding protein 1 isoform 1", "refseq_ac": [ { "id": "NP_058932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058932", "type": "external" } ], "gene_names_uniprotkb": "Pebp1; Pbp; Pebp", "gene_names_refseq": "HCNP; Pbp; Pebp1; Rkip", "protein_names_uniprotkb": "Phosphatidylethanolamine-binding protein 1; 23 kDa morphine-binding protein; HCNPpp; P23K; PEBP-1", "protein_names_refseq": "23 kDa morphine-binding protein; HCNPpp; P23K; PEBP-1; Raf-1 kinase inhibitor protein; hippocampal cholinergic neurostimulating peptide; phosphatidylethanolamine-binding protein 1 isoform 1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); ovarian cancer (Disease Ontology:DOID:2394); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29542); (R-RNO-5674135); (R-RNO-5675221)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10622376;12591138;1611510;1932083;1978248;21454685;22673903;25962787;26479924;28245468;29163033;31875544;34502162;35526109;7637590;8037677", "class_list": "", "function": "Axonal Odorant Receptors Mediate Axon Targeting., [RefSeq, PubMed]; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PEBP1, given its synaptic localization and its role as a signaling molecule acting via the ERK/MAPK pathway, could be a potential therapeutic target mediating drug-seeking behaviors associated with neuroinflammation., [RefSeq, PubMed]; RKIP attenuates ischemia-induced microglia cell apoptosis and activation through NF-kappaB pathway., [RefSeq, PubMed]; RKIP overexpression increases cardiac contractility mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates pressure overload-induced cardiac failure. Erratum:[Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217c. PMID: 26845407], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P31045", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045471 response to ethanol;GO:0051592 response to calcium ion;GO:0000165 MAPK cascade;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P31044-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31652-1", "uniprot_id": [ { "id": "SC6A4_RAT", "url": "https://www.uniprot.org/uniprot/P31652", "type": "external" } ], "mass": 70172.0, "length": 630, "protein_name": "Sodium-dependent serotonin transporter", "gene_name": "Slc6a4", "organism": "Rat", "refseq_name": "sodium-dependent serotonin transporter", "refseq_ac": [ { "id": "NP_037166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037166", "type": "external" } ], "gene_names_uniprotkb": "Slc6a4", "gene_names_refseq": "SERT; Slc6a4", "protein_names_uniprotkb": "Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; SERT; Solute carrier family 6 member 4", "protein_names_refseq": "5HT transporter; 5HTT; Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); serotonin transporter; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); autism spectrum disorder (Disease Ontology:DOID:0060041); alexithymia (Disease Ontology:DOID:0060131); Parkinsonism (Disease Ontology:DOID:0080855); obsessive-compulsive disorder (Disease Ontology:DOID:10933); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); heart disease (Disease Ontology:DOID:114); dengue hemorrhagic fever (Disease Ontology:DOID:12206); autistic disorder (Disease Ontology:DOID:12849); generalized anxiety disorder (Disease Ontology:DOID:14320); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); asthma (Disease Ontology:DOID:2841); substance abuse (Disease Ontology:DOID:302); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); liver cirrhosis (Disease Ontology:DOID:5082); borna disease (Disease Ontology:DOID:5154); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diverticulitis (Disease Ontology:DOID:7475); cocaine abuse (Disease Ontology:DOID:809); chronic fatigue syndrome (Disease Ontology:DOID:8544); sudden infant death syndrome (Disease Ontology:DOID:9007); leishmaniasis (Disease Ontology:DOID:9065); brain disease (Disease Ontology:DOID:936)", "pathway": " (rno:25553); (R-RNO-380615); (R-RNO-442660)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10407194;10716733;11709063;12944413;14642278;15627510;16870614;17310063;1765155;18317590;1944572;1948036;21730057;31201245;34937496;35043462;37572802;38220097;39128940;8601815;8968583", "class_list": "", "function": "Alteration of the alpha5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model., [RefSeq, PubMed]; Offspring's own serotonin transporter genotype, independently from the maternal one, increases anxiety- and depression-like behavior and alters neuroplasticity markers in rats., [RefSeq, PubMed]; Regional expression differences of SERT and TSPAN8 in hippocampus, cerebellum and cortex of wild-type young, adult and middle-aged rats., [RefSeq, PubMed]; Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination., [RefSeq, PubMed]; Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (By similarity) (PubMed:10407194, PubMed:10716733, PubMed:15627510, PubMed:1944572, PubMed:1948036, PubMed:21730057, PubMed:8601815). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse. Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (By similarity). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (By similarity) (PubMed:10407194, PubMed:10716733, PubMed:15627510, PubMed:1944572, PubMed:1948036, PubMed:21730057, PubMed:8601815). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (PubMed:14642278, PubMed:8968583)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 31, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P23976", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0051378 serotonin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0045121 membrane raft;GO:0045202 synapse", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0021941 negative regulation of cerebellar granule cell precursor proliferation;GO:0048484 enteric nervous system development;GO:0060179 male mating behavior;GO:0015844 monoamine transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P31652-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32851-1", "uniprot_id": [ { "id": "STX1A_RAT", "url": "https://www.uniprot.org/uniprot/P32851", "type": "external" } ], "mass": 33067.0, "length": 288, "protein_name": "Syntaxin-1A", "gene_name": "Stx1a", "organism": "Rat", "refseq_name": "syntaxin-1A", "refseq_ac": [ { "id": "NP_446240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446240", "type": "external" } ], "gene_names_uniprotkb": "Stx1a; Sap", "gene_names_refseq": "Stx1a", "protein_names_uniprotkb": "Syntaxin-1A; Neuron-specific antigen HPC-1; P35A; Synaptotagmin-associated 35 kDa protein", "protein_names_refseq": "P35A; neuron-specific antigen HPC-1; synaptotagmin-associated 35 kDa protein; syntaxin 1A (brain)-like; syntaxin 1A (brain); syntaxin-1A", "tax_id": 10116, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); disease of mental health (Disease Ontology:DOID:150); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116470); (R-RNO-181429); (R-RNO-181430); (R-RNO-210500); (R-RNO-212676); (R-RNO-264642); (R-RNO-449836); (R-RNO-5682910); (R-RNO-888590); (R-RNO-9609523)", "pathway_count": 10, "publication_count": 41, "publication_id_list": "10336434;10746715;10913252;11118447;11533035;11709063;11832227;12145319;12496247;12730201;1321498;1334074;14642278;14665625;1587842;16888141;17301173;18167541;18337752;19196426;19571812;20484665;21785414;22411134;22673903;23341457;26280336;28813412;33109704;33582301;34779769;34857632;34948351;36157213;37057886;7690687;7737992;7901002;9507000;9753330;9759724", "class_list": "", "function": "CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Munc18-dependent and -independent clustering of syntaxin in the plasma membrane of cultured endocrine cells., [RefSeq, PubMed]; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:17301173, PubMed:18167541, PubMed:20484665, PubMed:22411134, PubMed:28813412, PubMed:7901002). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane (PubMed:14665625, PubMed:16888141, PubMed:19571812). STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (PubMed:14665625, PubMed:16888141, PubMed:19571812). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (By similarity). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; SNAP23 decreases insulin secretion by competitively inhibiting the interaction between SNAP25 and STX1A., [RefSeq, PubMed]; Striatal Syntaxin 1A Is Associated with Development of Tourette Syndrome in an Iminodipropionitrile-Induced Animal Model. Publication Status: Online-Only, [RefSeq, PubMed]; The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE-SNARE interactions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0010701 positive regulation of norepinephrine secretion;GO:0006886 intracellular protein transport;GO:0016925 protein sumoylation;GO:0032940 secretion by cell", "synthesized_glycan_count": 0, "hit_score": 4.2, "record_id": "P32851-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50878-1", "uniprot_id": [ { "id": "RL4_RAT", "url": "https://www.uniprot.org/uniprot/P50878", "type": "external" } ], "mass": 47257.0, "length": 421, "protein_name": "Large ribosomal subunit protein uL4", "gene_name": "Rpl4", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL4", "refseq_ac": [ { "id": "NP_071955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071955", "type": "external" } ], "gene_names_uniprotkb": "Rpl4; Rpl1", "gene_names_refseq": "Rpl4", "protein_names_uniprotkb": "Large ribosomal subunit protein uL4; 60S ribosomal protein L1; 60S ribosomal protein L4", "protein_names_refseq": "60S ribosomal protein L1; 60S ribosomal protein L4; L1; large ribosomal subunit protein uL4", "tax_id": 10116, "disease": "", "pathway": " (rno:64302); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "15684048;22673903;29393594;7575549", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0003360 brainstem development;GO:0030154 cell differentiation;GO:0045773 positive regulation of axon extension;GO:0050772 positive regulation of axonogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P50878-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58295-1", "uniprot_id": [ { "id": "SC6A5_RAT", "url": "https://www.uniprot.org/uniprot/P58295", "type": "external" } ], "mass": 87842.0, "length": 799, "protein_name": "Sodium- and chloride-dependent glycine transporter 2", "gene_name": "Slc6a5", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent glycine transporter 2", "refseq_ac": [ { "id": "NP_976079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976079", "type": "external" } ], "gene_names_uniprotkb": "Slc6a5; Glyt2", "gene_names_refseq": "GLYT2; Slc6a5", "protein_names_uniprotkb": "Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5", "protein_names_refseq": "glyT-2; glycine transporter 2; sodium- and chloride-dependent glycine transporter 2; solute carrier family 6 (neurotransmitter transporter), member 5; solute carrier family 6 (neurotransmitter transporter, glycine), member 5", "tax_id": 10116, "disease": "hyperekplexia 3 (Disease Ontology:DOID:0060698); Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:171148); (R-RNO-442660)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14512139;22673903;25480793;32715433;33765249;33794243;34663888;40725001;8226790", "class_list": "", "function": "Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain., [RefSeq, PubMed]; Calcium-Dependent Regulation of the Neuronal Glycine Transporter GlyT2 by M2 Muscarinic Acetylcholine Receptors., [RefSeq, PubMed]; GLYT2 mRNA neurons are distributed in the ventrolateral medulla, the nucleus retroambiguus, the spinal trigeminal nucleus, the inferior olivary nucleus, and the border zone between the hypoglossal nucleus and reticular formation, [RefSeq, PubMed]; Rescue of two trafficking-defective variants of the neuronal glycine transporter GlyT2 associated to hyperekplexia., [RefSeq, PubMed]; Sodium- and chloride-dependent glycine transporter (PubMed:25480793, PubMed:8226790, PubMed:40725001). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:8226790). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:8226790)., [UniProtKB, PubMed, PubMed, PubMed]; The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "F1LNM6;Q6QDB3", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0046872 metal ion binding;GO:0015375 glycine:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0098690 glycinergic synapse;GO:0031045 dense core granule", "go_biological_process": "GO:0015816 glycine transport;GO:0060012 synaptic transmission, glycinergic;GO:0035725 sodium ion transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0098810 neurotransmitter reuptake", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P58295-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62747-1", "uniprot_id": [ { "id": "RHOB_RAT", "url": "https://www.uniprot.org/uniprot/P62747", "type": "external" } ], "mass": 22123.0, "length": 196, "protein_name": "Rho-related GTP-binding protein RhoB", "gene_name": "Rhob", "organism": "Rat", "refseq_name": "rho-related GTP-binding protein RhoB", "refseq_ac": [ { "id": "NP_071987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071987", "type": "external" } ], "gene_names_uniprotkb": "Rhob; Arhb", "gene_names_refseq": "Arhb; Rhob", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoB; 3.6.5.2", "protein_names_refseq": "ras homolog gene family, member B; rho-related GTP-binding protein RhoB", "tax_id": 10116, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); neurodegenerative disease (Disease Ontology:DOID:1289); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:64373); (R-RNO-114604); (R-RNO-416482); (R-RNO-416572); (R-RNO-5625740); (R-RNO-5625900); (R-RNO-5627117); (R-RNO-5663220); (R-RNO-9013026)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "13679852;1710770;26388235;27549397;31573047;38073570;8816443", "class_list": "", "function": "CDK5 and RhoB are involved in addiction-related signaling pathways or protein-protein interaction networks, [RefSeq, PubMed]; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity)., [UniProtKB]; MiR19a promoted proliferation, migration and invasion via the MMP/aSMA/SM22a signaling pathway by inhibiting RHOB, suggesting that miR19a is a possible regulatory factor of RHOB., [RefSeq, PubMed]; These results suggest that RhoB plays an important role in the hypoxia-induced activation of macrophages and the inflammatory response., [RefSeq, PubMed]; Upregulation of miR-21-5p rescues the inhibition of cardiomyocyte proliferation induced by high glucose through negative regulation of Rhob., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01121;Q9CUV7", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P62747-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true } ]